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354. Association of 6‐Minute Walk Performance and Physical Activity With Incident Ischemic Heart Disease Events and Stroke in Peripheral Artery Disease

Author

McDermott, Mary M., primary, Greenland, Philip, additional, Tian, Lu, additional, Kibbe, Melina R., additional, Green, David, additional, Zhao, Lihui, additional, Criqui, Michael H., additional, Guralnik, Jack M., additional, Ferrucci, Luigi, additional, Liu, Kiang, additional, Wilkins, John T., additional, Huffman, Mark D., additional, Shah, Sanjiv J., additional, Liao, Yihua, additional, and Lloyd‐Jones, Donald M., additional

Published
2015
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356. Incidence of cardiovascular risk factors in an Indian urban cohort results from the New Delhi birth cohort

Author

Huffman, Mark D., Prabhakaran, Dorairaj, Osmond, Clive, Fall, Caroline H.D., Tandon, Nikhil, Lakshmy, Ramakrishnan, Ramji, Siddharth, Khalil, Anita, Gera, Tarun, Prabhakaran, Poornima, Biswas, S.K. Dey, Reddy, K. Srinath, Bhargava, Santosh K., and Sachdev, Harshpal S.

Subjects
cardiovascular risk factors, Adult, Male, Indian Asians, Urban Population, Incidence, India, cohort, Article, Cohort Studies, Cardiovascular Diseases, Risk Factors, Hypertension, Diabetes Mellitus, Humans, Female, Longitudinal Studies, Obesity, Prospective Studies, Follow-Up Studies
Published
2010

360. Disparities in Cardiovascular Research Output and Citations From 52 African Countries: A Time‐Trend, Bibliometric Analysis (1999–2008)

Author

Bloomfield, Gerald S., primary, Baldridge, Abigail, additional, Agarwal, Anubha, additional, Huffman, Mark D., additional, Colantonio, Lisandro D., additional, Bahiru, Ehete, additional, Ajay, Vamadevan S., additional, Prabhakaran, Poornima, additional, Lewison, Grant, additional, and Prabhakaran, Dorairaj, additional

Published
2015
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362. Heart Disease and Stroke Statistics—2015 Update

Author

Mozaffarian, Dariush, primary, Benjamin, Emelia J., additional, Go, Alan S., additional, Arnett, Donna K., additional, Blaha, Michael J., additional, Cushman, Mary, additional, de Ferranti, Sarah, additional, Després, Jean-Pierre, additional, Fullerton, Heather J., additional, Howard, Virginia J., additional, Huffman, Mark D., additional, Judd, Suzanne E., additional, Kissela, Brett M., additional, Lackland, Daniel T., additional, Lichtman, Judith H., additional, Lisabeth, Lynda D., additional, Liu, Simin, additional, Mackey, Rachel H., additional, Matchar, David B., additional, McGuire, Darren K., additional, Mohler, Emile R., additional, Moy, Claudia S., additional, Muntner, Paul, additional, Mussolino, Michael E., additional, Nasir, Khurram, additional, Neumar, Robert W., additional, Nichol, Graham, additional, Palaniappan, Latha, additional, Pandey, Dilip K., additional, Reeves, Mathew J., additional, Rodriguez, Carlos J., additional, Sorlie, Paul D., additional, Stein, Joel, additional, Towfighi, Amytis, additional, Turan, Tanya N., additional, Virani, Salim S., additional, Willey, Joshua Z., additional, Woo, Daniel, additional, Yeh, Robert W., additional, and Turner, Melanie B., additional

Published
2015
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363. Executive Summary: Heart Disease and Stroke Statistics—2015 Update

Author

Mozaffarian, Dariush, primary, Benjamin, Emelia J., additional, Go, Alan S., additional, Arnett, Donna K., additional, Blaha, Michael J., additional, Cushman, Mary, additional, de Ferranti, Sarah, additional, Després, Jean-Pierre, additional, Fullerton, Heather J., additional, Howard, Virginia J., additional, Huffman, Mark D., additional, Judd, Suzanne E., additional, Kissela, Brett M., additional, Lackland, Daniel T., additional, Lichtman, Judith H., additional, Lisabeth, Lynda D., additional, Liu, Simin, additional, Mackey, Rachel H., additional, Matchar, David B., additional, McGuire, Darren K., additional, Mohler, Emile R., additional, Moy, Claudia S., additional, Muntner, Paul, additional, Mussolino, Michael E., additional, Nasir, Khurram, additional, Neumar, Robert W., additional, Nichol, Graham, additional, Palaniappan, Latha, additional, Pandey, Dilip K., additional, Reeves, Mathew J., additional, Rodriguez, Carlos J., additional, Sorlie, Paul D., additional, Stein, Joel, additional, Towfighi, Amytis, additional, Turan, Tanya N., additional, Virani, Salim S., additional, Willey, Joshua Z., additional, Woo, Daniel, additional, Yeh, Robert W., additional, and Turner, Melanie B., additional

Published
2015
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365. D-Dimer in the Months Leading up to Acute Coronary Events: A Case Crossover Study

Author

Green, David, primary, Liao, Yihua, additional, Vida, Loyda, additional, Greenland, Philip, additional, Huffman, Mark D, additional, Liu, Kiang J, additional, Lloyd-Jones, Donald M, additional, Shah, Sanjiv J, additional, Tian, Lu, additional, Tracy, Russell P, additional, Wilkins, John T, additional, Zhao, Lihui, additional, and McDermott, Mary M, additional

Published
2014
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368. Youth Manifesto on Non-Communicable Diseases

Author

Kishore, Sandeep P., Siegel, Karen R., Ahmad, Aria, Aitsi-Selmi, Amina A., Ali, Mohammed K., Baker, Phillip, Basu, Sanjay, Bitton, Asaf, Bloomfield, Gerald S., Bukhman, Gene, Emery, Eleanor, Feigl, Andrea B., Grepin, Karen, Huffman, Mark D., Kajana, Kiti, Khandelwal, Shweta, Kolappa, Kavitha, Liu, Chenhui, Lokhandwala, Naaznin, Marwah, Vishal, Mwatsama, Modi, Novak, Nicole, Nundy, Shantanu, Park, Paul H., Perez, Cristina Parsons, Price, Matthew R., Rapkin, Nikka, Rice, Hester, Seligman, Ben, Shah, Sumit, Silva, Joao da, Sridhar, Devi, Stuckler, David, Vedanthan, Rajesh, and Zaman, Justin

Published
2011
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370. Association of the von Willebrand Factor–ADAMTS13 Ratio With Incident Cardiovascular Events in Patients With Peripheral Arterial Disease.

Author

Green, David, Tian, Lu, Greenland, Philip, Liu, Kiang, Kibbe, Melina, Tracy, Russell, Shah, Sanjiv, Wilkins, John T., Huffman, Mark D., Liao, Yihua, Lloyd Jones, Donald, and McDermott, Mary M.

Abstract

Background: Platelet adhesion is mediated by von Willebrand factor (vWF), and disintegrin-like and metalloprotease domain with thrombospondin type-1 motif, number 13 (ADAMTS13) is a protease that cleaves vWF. A change in the balance between vWF and ADAMTS13 in favor of thrombosis might occur shortly before ischemic cardiovascular (CV) events. Objective: To determine whether vWF, ADAMTS13, and the ratio of vWF and ADAMTS13 change during the months preceding an acute CV event. Design: Prospective longitudinal observational study. Setting: Outpatient. Patients: A total of 595 participants with peripheral artery disease (PAD). Measurements: Blood samples were obtained every 2 months for up to 3 years and hemostatic factors examined at intervals preceding events. Results: Sixty-one participants (cases) experienced events and were matched to 122 PAD controls. During the 2-month interval prior to an event, cases (n = 48) had higher levels of the vWF and ADAMTS13 than controls (n = 95; P = .05), but significance was lost after adjusting for the baseline differences in myocardial infarction, unstable angina, and stroke. During the 10 months prior to an event, median values for vWF and the ratio of vWF and ADAMTS13 were higher in cases than in controls, but the differences were not statistically significant. However, in a subset of 20 patients with complete bimonthly data, there was a trend toward an increase in the ratio in the 10 months prior to a CV event (P = .04). Conclusion: In patients with PAD experiencing an ischemic CV event, a significant increase in the ratio of vWF to ADAMTS13 prior to the event could not be confirmed, although there was a weak trend in this direction. [ABSTRACT FROM AUTHOR]

Published
2017
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371. Association of 10‐Year and Lifetime Predicted Cardiovascular Disease Risk With Subclinical Atherosclerosis in South Asians: Findings From the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study

Author

Kandula, Namratha R., primary, Kanaya, Alka M., additional, Liu, Kiang, additional, Lee, Ji Young, additional, Herrington, David, additional, Hulley, Stephen B., additional, Persell, Stephen D., additional, Lloyd‐Jones, Donald M., additional, and Huffman, Mark D., additional

Published
2014
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377. PM173 Association between anthropometry, cardiovascular risk factors, and early life factors and adult measures of endothelial function: Results from the New Delhi Birth Cohort

Author

Huffman, Mark D., primary, Khalil, Anita, additional, Prabhakaran, Dorairaj, additional, Osmond, Clive, additional, Fall, Caroline, additional, Tandon, Nikhil, additional, Lakshmy, Ramakrishnan, additional, Prabhakaran, Poornima, additional, Biswas, S.K. Dey, additional, Ramji, Siddharth, additional, Sachdev, Harshpal S., additional, and Bhargava, Santosh K., additional

Published
2014
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378. Executive Summary: Heart Disease and Stroke Statistics—2014 Update

Author

Go, Alan S., primary, Mozaffarian, Dariush, additional, Roger, Véronique L., additional, Benjamin, Emelia J., additional, Berry, Jarett D., additional, Blaha, Michael J., additional, Dai, Shifan, additional, Ford, Earl S., additional, Fox, Caroline S., additional, Franco, Sheila, additional, Fullerton, Heather J., additional, Gillespie, Cathleen, additional, Hailpern, Susan M., additional, Heit, John A., additional, Howard, Virginia J., additional, Huffman, Mark D., additional, Judd, Suzanne E., additional, Kissela, Brett M., additional, Kittner, Steven J., additional, Lackland, Daniel T., additional, Lichtman, Judith H., additional, Lisabeth, Lynda D., additional, Mackey, Rachel H., additional, Magid, David J., additional, Marcus, Gregory M., additional, Marelli, Ariane, additional, Matchar, David B., additional, McGuire, Darren K., additional, Mohler, Emile R., additional, Moy, Claudia S., additional, Mussolino, Michael E., additional, Neumar, Robert W., additional, Nichol, Graham, additional, Pandey, Dilip K., additional, Paynter, Nina P., additional, Reeves, Matthew J., additional, Sorlie, Paul D., additional, Stein, Joel, additional, Towfighi, Amytis, additional, Turan, Tanya N., additional, Virani, Salim S., additional, Wong, Nathan D., additional, Woo, Daniel, additional, and Turner, Melanie B., additional

Published
2014
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379. Heart Disease and Stroke Statistics—2014 Update

Author

Go, Alan S., primary, Mozaffarian, Dariush, additional, Roger, Véronique L., additional, Benjamin, Emelia J., additional, Berry, Jarett D., additional, Blaha, Michael J., additional, Dai, Shifan, additional, Ford, Earl S., additional, Fox, Caroline S., additional, Franco, Sheila, additional, Fullerton, Heather J., additional, Gillespie, Cathleen, additional, Hailpern, Susan M., additional, Heit, John A., additional, Howard, Virginia J., additional, Huffman, Mark D., additional, Judd, Suzanne E., additional, Kissela, Brett M., additional, Kittner, Steven J., additional, Lackland, Daniel T., additional, Lichtman, Judith H., additional, Lisabeth, Lynda D., additional, Mackey, Rachel H., additional, Magid, David J., additional, Marcus, Gregory M., additional, Marelli, Ariane, additional, Matchar, David B., additional, McGuire, Darren K., additional, Mohler, Emile R., additional, Moy, Claudia S., additional, Mussolino, Michael E., additional, Neumar, Robert W., additional, Nichol, Graham, additional, Pandey, Dilip K., additional, Paynter, Nina P., additional, Reeves, Matthew J., additional, Sorlie, Paul D., additional, Stein, Joel, additional, Towfighi, Amytis, additional, Turan, Tanya N., additional, Virani, Salim S., additional, Wong, Nathan D., additional, Woo, Daniel, additional, and Turner, Melanie B., additional

Published
2014
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381. Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association.

Author

Go, Alan S, Go, Alan S, Mozaffarian, Dariush, Roger, Véronique L, Benjamin, Emelia J, Berry, Jarett D, Borden, William B, Bravata, Dawn M, Dai, Shifan, Ford, Earl S, Fox, Caroline S, Franco, Sheila, Fullerton, Heather J, Gillespie, Cathleen, Hailpern, Susan M, Heit, John A, Howard, Virginia J, Huffman, Mark D, Kissela, Brett M, Kittner, Steven J, Lackland, Daniel T, Lichtman, Judith H, Lisabeth, Lynda D, Magid, David, Marcus, Gregory M, Marelli, Ariane, Matchar, David B, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Mussolino, Michael E, Nichol, Graham, Paynter, Nina P, Schreiner, Pamela J, Sorlie, Paul D, Stein, Joel, Turan, Tanya N, Virani, Salim S, Wong, Nathan D, Woo, Daniel, Turner, Melanie B, American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Go, Alan S, Go, Alan S, Mozaffarian, Dariush, Roger, Véronique L, Benjamin, Emelia J, Berry, Jarett D, Borden, William B, Bravata, Dawn M, Dai, Shifan, Ford, Earl S, Fox, Caroline S, Franco, Sheila, Fullerton, Heather J, Gillespie, Cathleen, Hailpern, Susan M, Heit, John A, Howard, Virginia J, Huffman, Mark D, Kissela, Brett M, Kittner, Steven J, Lackland, Daniel T, Lichtman, Judith H, Lisabeth, Lynda D, Magid, David, Marcus, Gregory M, Marelli, Ariane, Matchar, David B, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Mussolino, Michael E, Nichol, Graham, Paynter, Nina P, Schreiner, Pamela J, Sorlie, Paul D, Stein, Joel, Turan, Tanya N, Virani, Salim S, Wong, Nathan D, Woo, Daniel, Turner, Melanie B, and American Heart Association Statistics Committee and Stroke Statistics Subcommittee

Published
2013

385. A cross-sectional study of the microeconomic impact of cardiovascular disease hospitalization in four low- and middle-income countries.

Author

Huffman, Mark D, Rao, Krishna D, Pichon-Riviere, Andres, Zhao, Dong, Harikrishnan, S, Ramaiya, Kaushik, Ajay, V S, Goenka, Shifalika, Calcagno, Juan I, Caporale, Joaquín E, Niu, Shaoli, Li, Yan, Liu, Jing, Thankappan, K R, Daivadanam, Meena, van Esch, Jan, Murphy, Adrianna, Moran, Andrew E, Gaziano, Thomas A, Suhrcke, Marc, Reddy, K Srinath, Leeder, Stephen, Prabhakaran, Dorairaj, Huffman, Mark D, Rao, Krishna D, Pichon-Riviere, Andres, Zhao, Dong, Harikrishnan, S, Ramaiya, Kaushik, Ajay, V S, Goenka, Shifalika, Calcagno, Juan I, Caporale, Joaquín E, Niu, Shaoli, Li, Yan, Liu, Jing, Thankappan, K R, Daivadanam, Meena, van Esch, Jan, Murphy, Adrianna, Moran, Andrew E, Gaziano, Thomas A, Suhrcke, Marc, Reddy, K Srinath, Leeder, Stephen, and Prabhakaran, Dorairaj

Abstract

OBJECTIVE: To estimate individual and household economic impact of cardiovascular disease (CVD) in selected low- and middle-income countries (LMIC). BACKGROUND: Empirical evidence on the microeconomic consequences of CVD in LMIC is scarce. METHODS AND FINDINGS: We surveyed 1,657 recently hospitalized CVD patients (66% male; mean age 55.8 years) from Argentina, China, India, and Tanzania to evaluate the microeconomic and functional/productivity impact of CVD hospitalization. Respondents were stratified into three income groups. Median out-of-pocket expenditures for CVD treatment over 15 month follow-up ranged from 354 international dollars (2007 INT$, Tanzania, low-income) to INT$2,917 (India, high-income). Catastrophic health spending (CHS) was present in >50% of respondents in China, India, and Tanzania. Distress financing (DF) and lost income were more common in low-income respondents. After adjustment, lack of health insurance was associated with CHS in Argentina (OR 4.73 [2.56, 8.76], India (OR 3.93 [2.23, 6.90], and Tanzania (OR 3.68 [1.86, 7.26] with a marginal association in China (OR 2.05 [0.82, 5.11]). These economic effects were accompanied by substantial decreases in individual functional health and productivity. CONCLUSIONS: Individuals in selected LMIC bear significant financial burdens following CVD hospitalization, yet with substantial variation across and within countries. Lack of insurance may drive much of the financial stress of CVD in LMIC patients and their families.

Published
2011
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386. Trans-disciplinary education and training for NCD prevention and control

Author

Siegel, Karen, Kishore, Sandeep P, Huffman, Mark D, Aitsi-Selmi, A, Baker, Phillip, Bitton, Asaf, Mwatsama, M, Ding, Eric l, Fiegl, Andrea B, Khandelwal, Shweta, Rapkin, Nikka, Seligman, Benjamin, Vedanthan, Rajesh, Feigl, Andrea B, Siegel, Karen, Kishore, Sandeep P, Huffman, Mark D, Aitsi-Selmi, A, Baker, Phillip, Bitton, Asaf, Mwatsama, M, Ding, Eric l, Fiegl, Andrea B, Khandelwal, Shweta, Rapkin, Nikka, Seligman, Benjamin, Vedanthan, Rajesh, and Feigl, Andrea B

Published
2011

387. Youth manifesto on non-communicable diseases

Author

Kishore, Sandeep P, Siegel, Karen, Ahmad, Aria, Aitsi-Selmi, A, Ali, Mohammed K, Baker, Phillip, Basu, Sanjay, Bitton, Asaf, Bloomfield, Gerald S, Bukhman, Gene, Emery, Elanor, Feigl, Andrea B, Grepin, Karen, Huffman, Mark D, Kajana, Kiti, Khandelwal, Shweta, Kolappa, Kavitha, Liu, Chenhui, Lokhandwala, Naaznin, Marwah, Vishal, Mwatsama, M, Novak, Nicole, Nundy, Shantanu, Park, Paul H, Perez, Cristina Parsons, Price, Matthew R, Rapkin, Nikka, Rice, Hester, Seligman, Benjamin, Shah, Sumit, da Silva, Joao, Sridhar, Devi, Stuckler, David, Vedanthan, Rajesh, Zaman, Justin, Kishore, Sandeep P, Siegel, Karen, Ahmad, Aria, Aitsi-Selmi, A, Ali, Mohammed K, Baker, Phillip, Basu, Sanjay, Bitton, Asaf, Bloomfield, Gerald S, Bukhman, Gene, Emery, Elanor, Feigl, Andrea B, Grepin, Karen, Huffman, Mark D, Kajana, Kiti, Khandelwal, Shweta, Kolappa, Kavitha, Liu, Chenhui, Lokhandwala, Naaznin, Marwah, Vishal, Mwatsama, M, Novak, Nicole, Nundy, Shantanu, Park, Paul H, Perez, Cristina Parsons, Price, Matthew R, Rapkin, Nikka, Rice, Hester, Seligman, Benjamin, Shah, Sumit, da Silva, Joao, Sridhar, Devi, Stuckler, David, Vedanthan, Rajesh, and Zaman, Justin

Published
2011

388. Predictors of carotid intima–media thickness and carotid plaque in young Indian adults: The New Delhi Birth Cohort

Author

Khalil, Anita, primary, Huffman, Mark D., additional, Prabhakaran, Dorairaj, additional, Osmond, Clive, additional, Fall, Caroline H.D., additional, Tandon, Nikhil, additional, Lakshmy, Ramakrishnan, additional, Prabhakaran, Poornima, additional, Biswas, S.K. Dey, additional, Ramji, Siddarth, additional, Sachdev, Harshpal S., additional, and Bhargava, Santosh K., additional

Published
2013
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392. Association between Gender, Process of Care Measures, and Outcomes in ACS in India: Results from the Detection and Management of Coronary Heart Disease (DEMAT) Registry

Author

Pagidipati, Neha J., primary, Huffman, Mark D., additional, Jeemon, Panniyammakal, additional, Gupta, Rajeev, additional, Negi, Prakash, additional, Jaison, Thannikot M., additional, Sharma, Satyavan, additional, Sinha, Nakul, additional, Mohanan, Padinhare, additional, Muralidhara, B. G., additional, Bijulal, Sasidharan, additional, Sivasankaran, Sivasubramonian, additional, Puri, Vijay K., additional, Jose, Jacob, additional, Reddy, K. Srinath, additional, and Prabhakaran, Dorairaj, additional

Published
2013
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395. Executive Summary: Heart Disease and Stroke Statistics—2013 Update

Author

Go, Alan S., primary, Mozaffarian, Dariush, additional, Roger, Véronique L., additional, Benjamin, Emelia J., additional, Berry, Jarett D., additional, Borden, William B., additional, Bravata, Dawn M., additional, Dai, Shifan, additional, Ford, Earl S., additional, Fox, Caroline S., additional, Franco, Sheila, additional, Fullerton, Heather J., additional, Gillespie, Cathleen, additional, Hailpern, Susan M., additional, Heit, John A., additional, Howard, Virginia J., additional, Huffman, Mark D., additional, Kissela, Brett M., additional, Kittner, Steven J., additional, Lackland, Daniel T., additional, Lichtman, Judith H., additional, Lisabeth, Lynda D., additional, Magid, David, additional, Marcus, Gregory M., additional, Marelli, Ariane, additional, Matchar, David B., additional, McGuire, Darren K., additional, Mohler, Emile R., additional, Moy, Claudia S., additional, Mussolino, Michael E., additional, Nichol, Graham, additional, Paynter, Nina P., additional, Schreiner, Pamela J., additional, Sorlie, Paul D., additional, Stein, Joel, additional, Turan, Tanya N., additional, Virani, Salim S., additional, Wong, Nathan D., additional, Woo, Daniel, additional, and Turner, Melanie B., additional

Published
2013
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396. Heart Disease and Stroke Statistics—2013 Update

Author

Go, Alan S., primary, Mozaffarian, Dariush, additional, Roger, Véronique L., additional, Benjamin, Emelia J., additional, Berry, Jarett D., additional, Borden, William B., additional, Bravata, Dawn M., additional, Dai, Shifan, additional, Ford, Earl S., additional, Fox, Caroline S., additional, Franco, Sheila, additional, Fullerton, Heather J., additional, Gillespie, Cathleen, additional, Hailpern, Susan M., additional, Heit, John A., additional, Howard, Virginia J., additional, Huffman, Mark D., additional, Kissela, Brett M., additional, Kittner, Steven J., additional, Lackland, Daniel T., additional, Lichtman, Judith H., additional, Lisabeth, Lynda D., additional, Magid, David, additional, Marcus, Gregory M., additional, Marelli, Ariane, additional, Matchar, David B., additional, McGuire, Darren K., additional, Mohler, Emile R., additional, Moy, Claudia S., additional, Mussolino, Michael E., additional, Nichol, Graham, additional, Paynter, Nina P., additional, Schreiner, Pamela J., additional, Sorlie, Paul D., additional, Stein, Joel, additional, Turan, Tanya N., additional, Virani, Salim S., additional, Wong, Nathan D., additional, Woo, Daniel, additional, and Turner, Melanie B., additional

Published
2013
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397. Association between anthropometry, cardiometabolic risk factors, & early life factors & adult measures of endothelial function: Results from the New Delhi Birth Cohort.

Author

Huffman, Mark D., Khalil, Anita, Osmond, Clive, Fall, Caroline H. D., Tandon, Nikhil, Lakshmy, Ramakrishnan, Ramji, Siddharth, Gera, Tarun, Prabhakaran, Poornima, Biswas, S. K. Dey, Reddy, K. Srinath, Bhargava, Santosh K., Sachdev, Harshpal S., and Prabhakaran, Dorairaj

Subjects
*ANTHROPOMETRY research, *PHYSICAL anthropology, *HEART metabolism, *ENDOTHELIAL cells, *EPITHELIAL cells
Abstract

Background & objectives: Abnormal endothelial function represents a preclinical marker of atherosclerosis. This study was conducted to evaluate associations between anthropometry, cardiometabolic risk factors, and early life factors and adult measures of endothelial function in a young urban Indian cohort free of clinical cardiovascular disease. Methods: Absolute changes in brachial artery diameter following cuff inflation and sublingual nitroglycerin (400 µg) were recorded to evaluate endothelium-dependent and -independent measures of endothelial function in 600 participants (362 men; 238 women) from the New Delhi Birth Cohort (2006-2009). Data on anthropometry, cardiometabolic risk factors, medical history, socio-economic position, and lifestyle habits were collected. Height and weight were recorded at birth, two and 11 yr of age. Age- and sex-adjusted linear regression models were developed to evaluate these associations. Results: The mean age of participants was 36±1 yr. Twenty two per cent men and 29 per cent women were obese (BMI > 30 kg/m²). Mean systolic blood pressure (SBP) was 131±14 and 119±13 mmHg, and diabetes prevalence was 12 and 8 per cent for men and women, respectively. Brachial artery diameter was higher for men compared with women both before (3.48±0.37 and 2.95±0.35 cm) and after hyperaemia (3.87±0.37 vs. 3.37±0.35 cm²). A similar difference was seen before and after nitroglycerin. Markers of increased adiposity, smoking, SBP, and metabolic syndrome, but not early life anthropometry, were inversely associated with endothelial function after adjustment for age and sex. Interpretation & conclusions: The analysis of the current prospective data from a young urban Indian cohort showed that cardiometabolic risk factors, but not early life anthropometry, were associated with worse endothelial function. [ABSTRACT FROM AUTHOR]

Published
2015
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