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1,773 results on '"Hofmann, B."'

361. Urey: Mars Organic and Oxidant Detector

Author

Bada, J. L., primary, Ehrenfreund, P., additional, Grunthaner, F., additional, Blaney, D., additional, Coleman, M., additional, Farrington, A., additional, Yen, A., additional, Mathies, R., additional, Amudson, R., additional, Quinn, R., additional, Zent, A., additional, Ride, S., additional, Barron, L., additional, Botta, O., additional, Clark, B., additional, Glavin, D., additional, Hofmann, B., additional, Josset, J. L., additional, Rettberg, P., additional, Robert, F., additional, and Sephton, M., additional

Published
2007
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372. Relationship between cardiac tissue glycation and skin autofluorescence in patients with coronary artery disease.

Author

Hofmann, B., Jacobs, K., Navarrete Santos, A., Wienke, A., Silber, R.E., and Simm, A.

Abstract

Aim During ageing, advanced glycation end-products (AGEs) accumulate in extracellular matrix proteins like collagen and contribute to a decline in organ function. As skin autofluorescence (sAF) can assess subcutaneous accumulation of fluorescent AGEs, this study aimed to investigate the relationship between AGE-modified cardiac tissue collagen and AGE-related sAF in coronary artery bypass graft (CABG) surgery patients. Methods Between January 2011 and January 2012, data from 72 consecutive male patients undergoing isolated CABG were prospectively recorded. Collagen fractions were isolated from the right atrial appendages of these patients by proteolysis and collagenase digestion. Collagen was quantified by hydroxyproline assay, and AGEs by AGE-related intrinsic fluorescence; sAF was measured using an autofluorescence reader. Results Biochemical analysis showed that the insoluble cardiac collagen fraction contained the highest amounts of accumulated AGEs; the AGE-related intrinsic fluorescence of this fraction increased with age ( P = 0.0001), blood glucose ( P = 0.002), HbA 1c ( P = 0.01) and sAF ( P = 0.008). Conclusion This study demonstrated for the first time a relationship between cardiac tissue glycation and AGE-related sAF. In addition, cardiac tissue glycation was associated with age, blood glucose and long-term glucose values in patients with coronary artery disease. [ABSTRACT FROM AUTHOR]

Published
2015
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373. Use of floss/interdental brushes is associated with lower risk for new cardiovascular events among patients with coronary heart disease.

Author

Reichert, S., Schlitt, A., Beschow, V., Lutze, A., Lischewski, S., Seifert, T., Dudakliewa, T., Gawe, R., Werdan, K., Hofmann, B., Schaller, H.‐G., and Schulz, S.

Subjects
CORONARY heart disease prevention, PERIODONTITIS, THERAPEUTIC use of biochemical markers, ACADEMIC medical centers, CHI-squared test, CONFIDENCE intervals, GENETIC polymorphisms, INTERLEUKINS, LONGITUDINAL method, MULTIVARIATE analysis, POLYMERASE chain reaction, REGRESSION analysis, RESEARCH funding, STATISTICS, TOOTH care & hygiene, LOGISTIC regression analysis, DATA analysis, PROPORTIONAL hazards models, DATA analysis software, DESCRIPTIVE statistics, KAPLAN-Meier estimator, LOG-rank test, ODDS ratio, MANN Whitney U Test, GENOTYPES, PREVENTION
Abstract

Background and Objective Periodontitis has been found to be associated with coronary heart disease ( CHD) and stroke. However, only little is known about whether periodontitis and associated confounders are associated with new cardiovascular events among patients with CHD. Material and Methods A total of 942 inpatients with CHD were examined regarding periodontitis, oral care habits, bacteria in the subgingival biofilm and the expression of interleukin-( IL)-6 c. (coding DNA)-174 genotypes (rs 1800793) to determine whether these confounders are associated with new cardiovascular events within a 1-year follow-up period. Adjusted hazard ratios ( HR) with respect of age, gender, smoking, body mass index, use of aids for interdental hygiene, plaque index, occurrence of severe periodontitis and further internal diseases such as diabetes, hypertension, dyslipoproteinemia, number of missing teeth, serological parameters and IL-6 genotypes were generated with Cox regression. Results In all, 941 cardiovascular patients completed the 1-year follow up and 7.3% of the patients achieved the primary endpoint (myocardial infarction: 2.1%, stroke/transient ischemic attack: 1.8%, cardiovascular deaths: 3.4%). Patients who reported practicing interdental cleaning were younger, less likely to be male or to have severe periodontitis, had a reduced tobacco exposure, had fewer missing teeth, less indices for plaque and bleeding on probing and a significant decreased adjusted risk for new cardiovascular events ( HR = 0.2, CI 0.06-0.6, p = 0.01) than those patients with CHD who did not report practicing interdental cleaning. We did not obtain significant increased HR for patients with severe periodontitis ( HR = 1.2, CI 0.7-2.1, p = 0.53), carriers of the IL-6 genotypes GC or CC ( HR = 1.4, CI 0.8-2.5, p = 0.24) and did not find a significant association between the number of detected various oral species and the incidence of the combined endpoint ( HR = 0.9, CI 0.8-1.01, p = 0.07). Conclusions These findings suggest that flossing and brushing of interdental spaces might reduce the risk for new cardiovascular events among patients with CHD. The hypothesis that interdental cleaning per se reduces the risk of new cardiovascular events should be examined in an interventional study. [ABSTRACT FROM AUTHOR]

Published
2015
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374. Inter-hospital transfer of ECMO-assisted patients with a portable miniaturized ECMO device: 4 years of experience.

Author

Raspé, C, Rückert, F, Metz, D, Hofmann, B, Neitzel, T, Stiller, M, Gielen, S, Nestler, F, Ebbighausen, N, Steinke, T, Bucher, M, and Bushnaq, H

Subjects
HOSPITAL admission & discharge, HEART failure treatment, LUNG disease treatment, ACADEMIC medical centers, BLOOD gases analysis, EXTRACORPOREAL membrane oxygenation, LONGITUDINAL method, MEDICAL care, MEDICAL equipment, MINIATURE electronic equipment, PATIENTS, SURVIVAL, DESCRIPTIVE statistics
Abstract

The article presents a study on portable extracorporeal membrane oxygenation (ECMO) systems during inter-hospital transfers of patients with cardiopulmonary failure. Topics include the specialized nature of the intensive care therapy of patients on ECMO systems, the Halles EcLs Program (HELP), and the use of the Eurosets Universal ECMO Set Halle tube system. It also features photographs of the ECMO system.

Published
2015
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377. First results from the North Iceland experiment

Author

Riedel, C., primary, Tryggvason, A., additional, Brandsdottír, B., additional, Dahm, T., additional, Stéfansson, R., additional, Hensch, M., additional, Böðvarsson, R., additional, Vogfjord, K. S., additional, Jakobsdottír, S., additional, Eken, T., additional, Herber, R., additional, Holmjarn, J., additional, Schnese, M., additional, Thölen, M., additional, Hofmann, B., additional, Sigurdsson, B., additional, and Winter, S., additional

Published
2006
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385. The Beagle 2 stereo camera system

Author

Griffiths, A.D., primary, Coates, A.J., additional, Josset, J.-L., additional, Paar, G., additional, Hofmann, B., additional, Pullan, D., additional, Rüffer, P., additional, Sims, M.R., additional, and Pillinger, C.T., additional

Published
2005
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396. The microscope for Beagle 2

Author

Thomas, N., primary, Lüthi, B.S., additional, Hviid, S.F., additional, Keller, H.U., additional, Markiewicz, W.J., additional, Blümchen, T., additional, Basilevsky, A.T., additional, Smith, P.H., additional, Tanner, R., additional, Oquest, C., additional, Reynolds, R., additional, Josset, J.-L., additional, Beauvivre, S., additional, Hofmann, B., additional, Rüffer, P., additional, and Pillinger, C.T., additional

Published
2004
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