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336 results on '"Goodwin Fk"'

302. Regular induction of hypomania by L-dopa in "bipolar" manic-depressive patients.

Author

Murphy DL, Brodie HK, Goodwin FK, and Bunney WE Jr

Subjects
Antidepressive Agents adverse effects, Catecholamines metabolism, Clinical Trials as Topic, Dopamine urine, Euphoria, Female, Humans, Hydrazines therapeutic use, Male, Methyldopa therapeutic use, Methyltyrosines pharmacology, Middle Aged, Phenylacetates cerebrospinal fluid, Phenylacetates urine, Placebos, Sleep, REM drug effects, Stereoisomerism, Visual Cortex drug effects, Bipolar Disorder drug therapy, Dihydroxyphenylalanine adverse effects, Psychomotor Disorders chemically induced
Published
1971
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303. L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.

Author

Goodwin FK, Murphy DL, Brodie HK, and Bunney WE Jr

Subjects
Aged, Aggression drug effects, Anger drug effects, Behavior drug effects, Bipolar Disorder chemically induced, Brain Chemistry, Carboxy-Lyases antagonists & inhibitors, Catecholamines analysis, Catecholamines metabolism, Catecholamines urine, Cerebral Cortex drug effects, Clinical Trials as Topic, Depression urine, Digestive System drug effects, Dihydroxyphenylalanine adverse effects, Dihydroxyphenylalanine pharmacology, Dihydroxyphenylalanine urine, Evoked Potentials drug effects, Female, Hemodynamics drug effects, Humans, Male, Monoamine Oxidase Inhibitors pharmacology, Parkinson Disease drug therapy, Placebos, Reserpine pharmacology, Sleep drug effects, Brain metabolism, Catecholamines therapeutic use, Depression drug therapy, Dihydroxyphenylalanine administration & dosage, Dihydroxyphenylalanine therapeutic use
Published
1970

304. Lithium.

Author

Goodwin FK, Murphy DL, and Bunney WE Jr

Subjects
Clinical Trials as Topic, Depression drug therapy, Humans, Placebos, Bipolar Disorder drug therapy, Lithium therapeutic use
Published
1969
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305. The compensation problem.

Author

Hollender MH, Goodwin FK, Fleiss AN, Butz JL, Mariner AS, Kaplan EA, Hunt WL, and Pearl NH

Subjects
Diagnosis, Differential, Humans, Jurisprudence, Male, Middle Aged, Neurotic Disorders diagnosis, Psychotic Disorders diagnosis, Disability Evaluation, Malingering, Psychotherapy
Published
1965

307. Depressions following reserpine: a reevaluation.

Author

Goodwin FK and Bunney WE Jr

Subjects
Administration, Oral, Depression complications, Depression drug therapy, Depression therapy, Dreams drug effects, Drug Therapy, Combination, Electroconvulsive Therapy, Humans, Hypertension drug therapy, Imipramine analogs & derivatives, Imipramine therapeutic use, Monoamine Oxidase Inhibitors therapeutic use, Neurotransmitter Agents metabolism, Reserpine administration & dosage, Reserpine pharmacology, Reserpine therapeutic use, Risk, Sleep drug effects, Time Factors, Depression chemically induced, Reserpine adverse effects
Published
1971

309. L-dopa in depressed patients.

Author

Bunney WE Jr, Murphy DL, Brodie HK, and Goodwin FK

Subjects
Animals, Humans, Parkinson Disease drug therapy, Depression chemically induced, Dihydroxyphenylalanine adverse effects
Published
1970
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310. Clinical and pharmacological investigations of the psychobiology of the affective disorders.

Author

Murphy DL, Goodwin FK, and Bunney WE Jr

Subjects
Antidepressive Agents therapeutic use, Behavior, Bipolar Disorder enzymology, Bipolar Disorder genetics, Bipolar Disorder metabolism, Catecholamines metabolism, Depression drug therapy, Dihydroxyphenylalanine therapeutic use, Humans, Lithium therapeutic use, MMPI, Methyltyrosines therapeutic use, Sleep drug effects, Sleep, REM drug effects, Time Factors, Bipolar Disorder drug therapy, Depression physiopathology
Published
1971
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311. 9 -Tetrahydrocannabinol in depressed patients.

Author

Kotin J, Post RM, and Goodwin FK

Subjects
Administration, Oral, Adult, Affect drug effects, Affective Symptoms chemically induced, Anxiety, Body Image drug effects, Clinical Trials as Topic, Depersonalization chemically induced, Dronabinol administration & dosage, Dronabinol adverse effects, Dronabinol pharmacology, Dronabinol therapeutic use, Female, Humans, Informed Consent, Male, Middle Aged, Placebos, Pulse drug effects, Self Concept drug effects, Sleep drug effects, Cannabis therapeutic use, Depression drug therapy, Phytotherapy
Published
1973
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312. Drug treatment of depressed patients referred for hospitalization.

Author

Kotin J, Post RM, and Goodwin FK

Subjects
Adult, Antidepressive Agents administration & dosage, Attitude of Health Personnel, Dose-Response Relationship, Drug, Female, Humans, Lithium administration & dosage, Male, Outpatient Clinics, Hospital, Phenothiazines administration & dosage, Psychiatric Status Rating Scales, Antidepressive Agents therapeutic use, Depression drug therapy, Hospitalization
Published
1973
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313. Effect of L-tryptophan on brain serotonin metabolism in depressed patients.

Author

Dunner DL and Goodwin FK

Subjects
Brain metabolism, Clinical Trials as Topic, Depression cerebrospinal fluid, Depression drug therapy, Evaluation Studies as Topic, Humans, Hydroxyindoleacetic Acid cerebrospinal fluid, Placebos, Probenecid pharmacology, Spinal Puncture, Tryptophan therapeutic use, Brain Chemistry drug effects, Depression metabolism, Serotonin metabolism, Tryptophan pharmacology
Published
1972
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315. Lithium response in unipolar versus bipolar depression.

Author

Goodwin FK, Murphy DL, Dunner DL, and Bunney WE Jr

Subjects
Adult, Bipolar Disorder diagnosis, Carbonates, Clinical Trials as Topic, Depression diagnosis, Evaluation Studies as Topic, Female, Hospitalization, Humans, Male, Middle Aged, Placebos, Remission, Spontaneous, Bipolar Disorder drug therapy, Depression drug therapy, Lithium therapeutic use
Published
1972
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316. The stages of mania. A longitudinal analysis of the manic episode.

Author

Carlson GA and Goodwin FK

Subjects
Acute Disease, Adolescent, Adult, Delusions diagnosis, Diagnosis, Differential, Employment, Family, Female, Follow-Up Studies, Hallucinations diagnosis, Hospitalization, Humans, Interpersonal Relations, Male, Middle Aged, Prognosis, Remission, Spontaneous, Retrospective Studies, Schizophrenia diagnosis, Social Adjustment, Social Behavior, Verbal Behavior, Bipolar Disorder diagnosis
Published
1973
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317. Assortative mating in the affective disorders.

Author

Gershon ES, Dunner DL, Sturt L, and Goodwin FK

Subjects
Affective Symptoms genetics, Female, Hospitalization, Humans, Interview, Psychological, Male, Medical Records, Bipolar Disorder genetics, Depression genetics, Marriage
Published
1973

318. Effect of probenecid on free 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) and its sulphate in human cerebrospinal fluid.

Author

Gordon EK, Oliver J, Goodwin FK, Chase TN, and Post RM

Subjects
Biological Transport, Active, Brain metabolism, Catechols metabolism, Chromatography, Gas, Fluorometry, Glycols metabolism, Humans, Hydroxyindoleacetic Acid cerebrospinal fluid, Mental Disorders metabolism, Sulfuric Acids cerebrospinal fluid, Sulfuric Acids metabolism, Time Factors, Catechols cerebrospinal fluid, Glycols cerebrospinal fluid, Probenecid pharmacology
Published
1973
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319. Behavioral effects of l-dopa in man.

Author

Goodwin FK

Subjects
Adult, Aged, Cerebral Cortex drug effects, Cognition Disorders chemically induced, Confusion chemically induced, Delirium chemically induced, Delusions chemically induced, Depression chemically induced, Depression drug therapy, Dihydroxyphenylalanine pharmacology, Dihydroxyphenylalanine therapeutic use, Emotions drug effects, Evoked Potentials drug effects, Female, Humans, Male, Motor Activity drug effects, Parkinson Disease drug therapy, Psychoses, Substance-Induced etiology, Sexual Behavior drug effects, Sleep drug effects, Thinking drug effects, Dihydroxyphenylalanine adverse effects, Mental Disorders chemically induced
Published
1971

320. Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique.

Author

Goodwin FK, Post RM, Dunner DL, and Gordon EK

Subjects
Affective Symptoms metabolism, Biological Transport, Active drug effects, Bipolar Disorder cerebrospinal fluid, Brain metabolism, Brain Chemistry drug effects, Depression cerebrospinal fluid, Dopamine metabolism, Heroin Dependence metabolism, Humans, Methadone, Norepinephrine metabolism, Serotonin metabolism, Synaptic Transmission, Affective Symptoms cerebrospinal fluid, Hydroxyindoleacetic Acid cerebrospinal fluid, Phenylacetates cerebrospinal fluid, Probenecid pharmacology
Published
1973
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321. Central norepinephrine metabolism in affective illness: MHPG in the cerebrospinal fluid.

Author

Post RM, Gordon EK, Goodwin FK, and Bunney WE Jr

Subjects
Bipolar Disorder metabolism, Brain metabolism, Chromatography, Gas, Depression metabolism, Epinephrine metabolism, Humans, Nervous System Diseases cerebrospinal fluid, Bipolar Disorder cerebrospinal fluid, Catechols cerebrospinal fluid, Depression cerebrospinal fluid, Glycols cerebrospinal fluid
Abstract

Concentrations of the norepinephrine metabolite 3-methoxy-4-hydroxyphenyl glycol in cerebrospinal fluid were measured by a gas chromatographic method in 34 patients with affective illness and in 44 controls. Concentrations of this metabolite in spinal fluid were significantly lower in depressed patients than in controls or manic patients. These low values may occur secondary to depressive phenomena such as reduced psychomotor activity, or they may reflect a primary change in norepinephrine metabolism in depressive illness.

Published
1973
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322. Toward a biology of affective disorders. Genetic contributions.

Author

Gershon ES, Dunner DL, and Goodwin FK

Subjects
Adjustment Disorders epidemiology, Affective Symptoms epidemiology, Affective Symptoms etiology, Alcoholism epidemiology, Depressive Disorder, Major epidemiology, Diseases in Twins, Environment, Family, Female, Genes, Dominant, Genetic Diseases, Inborn, Genetics, Medical, Hospitalization, Humans, Male, Models, Psychological, Personality Disorders, Research, Schizophrenia epidemiology, Schizophrenia genetics, Sex Chromosomes, Sex Factors, Suicide, Affective Symptoms genetics
Published
1971
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323. L-dopa, dopamine, and hypomania.

Author

Murphy DL, Goodwin FK, Brodie HK, and Bunney WE Jr

Subjects
Adult, Bipolar Disorder drug therapy, Bipolar Disorder urine, Brain metabolism, Brain Chemistry drug effects, Depression urine, Dihydroxyphenylalanine administration & dosage, Dihydroxyphenylalanine pharmacology, Dihydroxyphenylalanine urine, Dopamine metabolism, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Motor Activity drug effects, Norepinephrine metabolism, Phenylacetates urine, Placebos, Depression drug therapy, Dihydroxyphenylalanine therapeutic use, Dopamine urine
Published
1973
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324. Psychiatric side effects of levodopa in man.

Author

Goodwin FK

Subjects
Animals, Brain drug effects, Catecholamines metabolism, Delirium chemically induced, Dihydroxyphenylalanine administration & dosage, Dopamine metabolism, Female, Haplorhini, Humans, Male, Methylation, Methyltyrosines metabolism, Rats, Sexual Behavior drug effects, Time Factors, Cognition Disorders chemically induced, Depression chemically induced, Dihydroxyphenylalanine adverse effects, Hyperkinesis chemically induced, Parkinson Disease drug therapy, Psychoses, Substance-Induced
Published
1971

325. Quantitative studies of norepinephrine uptake by synaptosomes.

Author

Colburn RW, Goodwin FK, Murphy DL, Bunney WE Jr, and Davis JM

Subjects
Animals, Bicarbonates pharmacology, Chlorides pharmacology, Depression, Chemical, Kinetics, Male, Phosphates pharmacology, Rats, Sulfates pharmacology, Brain metabolism, Nerve Endings metabolism, Norepinephrine metabolism, Potassium pharmacology, Reserpine pharmacology, Sodium pharmacology
Published
1968
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326. Aldosterone and sodium response to lithium administration in man.

Author

Murphy DL, Goodwin FK, and Bunney WE Jr

Subjects
Adult, Bipolar Disorder drug therapy, Body Weight drug effects, Carbonates adverse effects, Clinical Trials as Topic, Depression drug therapy, Diuresis drug effects, Female, Humans, Lithium blood, Lithium therapeutic use, Male, Middle Aged, Placebos, Potassium blood, Sodium blood, Urine, Water-Electrolyte Balance drug effects, Aldosterone urine, Lithium pharmacology, Sodium urine
Published
1969
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328. A behavioral-biochemical study of lithium treatment.

Author

Bunney WE Jr, Goodwin FK, Davis JM, and Fawcett JA

Subjects
Adult, Bipolar Disorder blood, Bipolar Disorder prevention & control, Bipolar Disorder therapy, Bipolar Disorder urine, Carbonates blood, Carbonates therapeutic use, Carbonates urine, Clinical Trials as Topic, Creatinine urine, Female, Humans, Lithium administration & dosage, Lithium blood, Lithium urine, Magnesium blood, Male, Middle Aged, Placebos, Potassium blood, Psychiatric Nursing, Psychiatric Status Rating Scales, Psychotherapy, Sodium blood, Sodium urine, Time Factors, Bipolar Disorder drug therapy, Lithium therapeutic use
Published
1968
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329. The switch process from depression to mania: relationship to drugs which alter brain amines.

Author

Bunney WE Jr, Murphy DL, Goodwin FK, and Borge GF

Subjects
Behavior drug effects, Bipolar Disorder metabolism, Bipolar Disorder physiopathology, Brain drug effects, Dopamine urine, Electroencephalography, Epinephrine urine, Female, Humans, Male, Norepinephrine urine, Placebos, Sleep, Sleep, REM, Time Factors, Amitriptyline therapeutic use, Bipolar Disorder drug therapy, Brain metabolism, Catecholamines metabolism, Depression, Ephedrine therapeutic use, Imipramine therapeutic use
Published
1970
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330. L-dopa with MK 485 for depression.

Author

Goodwin FK and Brodie HK

Subjects
Clinical Trials as Topic, Humans, Placebos, Carboxy-Lyases antagonists & inhibitors, Depression therapy, Dihydroxyphenylalanine therapeutic use, Hydrazines therapeutic use, Propionates therapeutic use
Published
1970
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331. Effect of L-DOPA on depression.

Author

Bunney WE, Janowsky DS, Goodwin FK, Davis JM, Brodie HK, Murphy DL, and Chase TN

Subjects
Clinical Trials as Topic, Dihydroxyphenylalanine administration & dosage, Female, Humans, Middle Aged, Placebos, Depression drug therapy, Dihydroxyphenylalanine therapeutic use
Published
1969
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332. Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness.

Author

Post RM, Kotin J, Goodwin FK, and Gordon EK

Subjects
Adult, Affect, Aged, Catechols cerebrospinal fluid, Depression cerebrospinal fluid, Depression metabolism, Dopamine metabolism, Female, Glycols cerebrospinal fluid, Humans, Male, Middle Aged, Norepinephrine metabolism, Physical Exertion, Rest, Serotonin metabolism, Spinal Puncture, Verbal Behavior, Affective Symptoms cerebrospinal fluid, Hydroxyindoleacetic Acid cerebrospinal fluid, Motor Activity, Phenylacetates cerebrospinal fluid
Published
1973
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333. Urinary cyclic A.M.P. in affective illness.

Author

Paul MI, Cramer H, and Goodwin FK

Subjects
Bipolar Disorder drug therapy, Cyclic AMP urine, Dihydroxyphenylalanine therapeutic use, Humans, Lithium therapeutic use, Adenine Nucleotides urine, Bipolar Disorder urine
Published
1970
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335. Amine metabolites in human cerebrospinal fluid: effects of cord transection and spinal fluid block.

Author

Post RM, Goodwin FK, Gordon E, and Watkin DM

Subjects
Adult, Age Factors, Cerebrospinal Fluid physiology, Cerebrospinal Fluid Proteins analysis, Erythrocyte Count, Humans, Leukocyte Count, Middle Aged, Spectrum Analysis, Spinal Cord Injuries blood, Time Factors, Catechols cerebrospinal fluid, Glycols cerebrospinal fluid, Hydroxyindoleacetic Acid cerebrospinal fluid, Phenylacetates cerebrospinal fluid, Spinal Cord Injuries cerebrospinal fluid
Abstract

Patients with spinal cord transection had normal concentrations of 5-hydroxyindoleacetic acid and low concentrations of 3-methoxy-4-hydroxyphenyl glycol in lumbar cerebrospinal fluid. The presence or absence of spinal fluid block in these patients did not affect concentrations of either amine metabolite. However, the concentration of homovanillic acid was lower in patients with spinal fluid block than in those without block. The results suggest that the spinal cord contributes to concentrations of 3-methoxy-4-hydroxyphenyl glycol and possibly 5-hydroxyindoleacetic acid, but contributes little to that of homovanillic acid in the lumbar spinal fluid of man.

Published
1973
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336. Leukocytosis during lithium treatment.

Author

Murphy DL, Goodwin FK, and Bunney WE Jr

Subjects
Blood Cell Count, Hematocrit, Humans, Lithium administration & dosage, Bipolar Disorder drug therapy, Leukocytosis chemically induced, Lithium adverse effects
Published
1971
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