201. Alpha-interferon therapy for essential thrombocythaemia.
- Author
-
Giles FJ, Singer CR, Gray AG, Yong KL, Brozovic M, Davies SC, Grant IR, Hoffbrand AV, Machin SJ, and Mehta AB
- Subjects
- Adult, Aged, Female, Hemoglobins metabolism, Humans, Leukocyte Count, Male, Middle Aged, Platelet Count, Thrombocythemia, Essential blood, Interferon Type I therapeutic use, Thrombocythemia, Essential therapy
- Abstract
18 patients with symptomatic essential thrombocythaemia were treated with recombinant alpha interferon (2a or 2b). Subcutaneous dosage regimens, which were well-tolerated, selectively lowered the platelet count and relieved symptoms in all patients, whether previously treated or untreated. Recombinant alpha-interferon may offer a non-leukaemogenic alternative therapy for these patients.
- Published
- 1988
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