Search

Your search keyword '"French, Tim"' showing total 300 results
Start Over Author "French, Tim"
300 results on '"French, Tim"'

251. A Text-Independent Forced Alignment Method for Automatic Phoneme Segmentation

Author

Wohlan, Bryce, Pham, Duc-Son, Chan, Kit Yan, Ward, Roslyn, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

252. Cognitive Impairment Prediction by Normal Cognitive Brain MRI Scans Using Deep Learning

Author

Bardwell, Justin, Hassan, Ghulam Mubashar, Salami, Farzaneh, Akhtar, Naveed, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

253. Multi-componential Emotion Recognition in VR Using Physiological Signals

Author

Somarathna, Rukshani, Quigley, Aaron, Mohammadi, Gelareh, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

254. Automated Fish Classification Using Unprocessed Fatty Acid Chromatographic Data: A Machine Learning Approach

Author

Wood, Jesse, Nguyen, Bach Hoai, Xue, Bing, Zhang, Mengjie, Killeen, Daniel, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

256. Non-linear Continuous Action Spaces for Reinforcement Learning in Type 1 Diabetes

Author

Hettiarachchi, Chirath, Malagutti, Nicolo, Nolan, Christopher J., Suominen, Hanna, Daskalaki, Elena, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

257. 3D Face Reconstruction with Mobile Phone Cameras for Rare Disease Diagnosis

Author

Liu, Yiwei, Li, Ling, An, Senjian, Helmholz, Petra, Palmer, Richard, Baynam, Gareth, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

258. Multiclass Classification for GvHD Prognosis Prior to Allogeneic Stem Cell Transplantation

Author

Khaled, Md. Asif Bin, Hossain, Md. Junayed, Rahman, Saifur, Ferdaus, Jannatul, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

259. Automated Radiology Report Generation Using a Transformer-Template System: Improved Clinical Accuracy and an Assessment of Clinical Safety

Author

Abela, Brandon, Abu-Khalaf, Jumana, Yang, Chi-Wei Robin, Masek, Martin, Gupta, Ashu, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

260. Boosted Self–evolving Neural Networks for Pattern Recognition

Author

Woodford, Brendon J., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

261. Multiclass Malware Classification Using Either Static Opcodes or Dynamic API Calls

Author

Chanajitt, Rajchada, Pfahringer, Bernhard, Gomes, Heitor Murilo, Yogarajan, Vithya, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

262. A Novel Approach to Time Series Complexity via Reservoir Computing

Author

Thorne, Braden, Jüngling, Thomas, Small, Michael, Corrêa, Débora, Zaitouny, Ayham, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

263. Machine Learning Inspired Fault Detection of Dynamical Networks

Author

Tan, Eugene, Corrêa, Débora C., Stemler, Thomas, Small, Michael, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

264. Active Learning for kNN Using Instance Impact

Author

Qayyumi, Sayed Waleed, Park, Laurence A. F., Obst, Oliver, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

265. Understanding Document Data Sources Using Ontologies with Referring Expressions

Author

Borgida, Alexander, Franconi, Enrico, Toman, David, Weddell, Grant, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

266. Predicting Marimba Stickings Using Long Short-Term Memory Neural Networks

Author

Chong, Jet Kye, Corrêa, Débora, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

267. QUARRY: A Graph Model for Queryable Association Rules

Author

Stewart, Michael, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

270. Belief Revision with Dishonest Reports

Author

Hunter, Aaron, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

272. Evolving Effective Ensembles for Image Classification Using Multi-objective Multi-tree Genetic Programming

Author

Fan, Qinglan, Bi, Ying, Xue, Bing, Zhang, Mengjie, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

273. Using Context-Free Grammar to Generate Synthetic Technical Short Texts

Author

Bikaun, Tyler, Stewart, Michael, Hodkiewicz, Melinda, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

276. Evolution Strategies for Sparse Reward Gridworld Environments

Author

Moy, Glennn, Shekh, Slava, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

277. Does a Compromise on Fairness Exist in Using AI Models?

Author

Zhou, Jianlong, Li, Zhidong, Xiao, Chun, Chen, Fang, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

279. Fairness Aware Swarm-based Machine Learning for Data Streams

Author

Pham, Diem, Tran, Binh, Nguyen, Su, Alahakoon, Damminda, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

280. Explainable Detection of Microplastics Using Transformer Neural Networks

Author

Barker, Max, Willans, Meg, Pham, Duc-Son, Krishna, Aneesh, Hackett, Mark, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

281. FDGATII: Fast Dynamic Graph Attention with Initial Residual and Identity

Author

Kulatilleke, Gayan K., Portmann, Marius, Ko, Ryan, Chandra, Shekhar S., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

282. Explainable Network Intrusion Detection Using External Memory Models

Author

Hutchison, Jack, Pham, Duc-Son, Soh, Sie-Teng, Ling, Huo-Chong, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

283. Towards Explainable AutoML Using Error Decomposition

Author

Owen, Caitlin A., Dick, Grant, Whigham, Peter A., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

284. Are Graph Neural Network Explainers Robust to Graph Noises?

Author

Li, Yiqiao, Verma, Sunny, Yang, Shuiqiao, Zhou, Jianlong, Chen, Fang, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

285. Diverse Audio-to-Video GAN using Multiscale Image Fusion

Author

Aldausari, Nuha, Sowmya, Arcot, Marcus, Nadine, Mohammadi, Gelareh, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

286. SG-Shuffle: Multi-aspect Shuffle Transformer for Scene Graph Generation

Author

Bui, Anh Duc, Han, Soyeon Caren, Poon, Josiah, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

287. Automated On-Vehicle Road Defect Data Collection and Detection

Author

Todd, Zachary, Li, Heyang, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

289. Impact of Mathematical Norms on Convergence of Gradient Descent Algorithms for Deep Neural Networks Learning

Author

Cai, Linzhe, Yu, Xinghuo, Li, Chaojie, Eberhard, Andrew, Nguyen, Lien Thuy, Doan, Chuong Thai, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

290. Multi-view Based Clustering of 3D LiDAR Point Clouds for Intelligent Vehicles

Author

Jie, Haoxiang, Ning, Zuotao, Zhao, Qixi, Liu, Wei, Hu, Jun, Gao, Jian, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

291. Vision Transformer Based Model for Describing a Set of Images as a Story

Author

Malakan, Zainy M., Hassan, Ghulam Mubashar, Mian, Ajmal, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

292. Zero-shot Personality Perception From Facial Images

Author

Gan, Peter Zhuowei, Sowmya, Arcot, Mohammadi, Gelareh, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Aziz, Haris, editor, Corrêa, Débora, editor, and French, Tim, editor

Published
2022
Full Text
View/download PDF

293. Testing for homologous recombination repair or homologous recombination deficiency for poly (ADP-ribose) polymerase inhibitors: A current perspective.

Author

Herzog, Thomas J., Vergote, Ignace, Gomella, Leonard G., Milenkova, Tsveta, French, Tim, Tonikian, Raffi, Poehlein, Christian, and Hussain, Maha

Subjects
*PANCREATIC tumors, *GENETICS, *OVARIAN tumors, *BRCA genes, *ANTINEOPLASTIC agents, *METABOLIC disorders, *DNA repair, *BREAST tumors, *PROSTATE tumors
Abstract

Poly (ADP-ribose) polymerase inhibitors (PARPis) have demonstrated clinical activity in patients with BRCA1 and/or BRCA2 mutated breast, ovarian, prostate, and pancreatic cancers. Notably, BRCA mutations are associated with defects in the homologous recombination repair (HRR) pathway. This homologous recombination deficiency (HRD) phenotype can also be observed as genomic instability in tumour cells. Accordingly, PARPi sensitivity has been observed in various tumours with HRD, independent of BRCA mutations. Currently, four PARPis are approved by regulatory agencies for the treatment of cancer across multiple tumour types. Most indications are specific to tumours with a confirmed BRCA mutation, mutations in other HRR-related genes, HRD evidenced by genomic instability, or evidence of platinum sensitivity. Regulatory agencies have also approved companion and complementary diagnostics to facilitate patient selection for each PARPi indication. This review aims to summarise the biological basis, clinical validation, and clinical relevance of the available diagnostic methods and assays to assess HRD. • Several biomarker tests are available to determine patient selection for PARPis. • These tests identify tumours with HRD and help determine sensitivity to PARPis. • We reviewed biomarker tests to assess HRD and their relevance for PARPi treatment. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

294. Accelerating worst case execution time analysis of timed automata models with cyclic behaviour.

Author

Al-Bataineh, Omar, Reynolds, Mark, and French, Tim

Subjects
*MACHINE theory, *ROBOTS, *MATHEMATICAL models, *ALGORITHMS, *ALGEBRA
Abstract

The paper presents a new efficient algorithm for computing worst case execution time (WCET) of systems modelled as timed automata (TA). The algorithm uses a set of abstraction techniques that improve significantly the efficiency of WCET analysis of TA models with cyclic behaviour. We show that the proposed abstractions are exact with respect to the WCET problem in the sense that the WCET computed in the abstract model is equal to the one computed in the concrete model. We also compare our algorithm with the one implemented in the model checker UPPAAL which shows that when infinite cycles exist (i.e. cycles that can be run infinitely often), UPPAAL's algorithm may not terminate, and when largely repetitive finite cycles exist (i.e. cycles that can be run a large number of times but finite), UPPAAL's algorithm suffers from the state space explosion, thus leading to a low efficiency or resource exhaustion. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

296. Refinement modal logic.

Author

Bozzelli, Laura, van Ditmarsch, Hans, French, Tim, Hales, James, and Pinchinat, Sophie

Subjects
*MODAL logic, *BISIMULATION, *COMPUTER operators, *APPLICATION software, *MULTIAGENT systems, *AXIOMS
Abstract

In this paper we present refinement modal logic . A refinement is like a bisimulation, except that from the three relational requirements only ‘atoms’ and ‘back’ need to be satisfied. Our logic contains a new operator ∀ in addition to the standard box modalities for each agent. The operator ∀ acts as a quantifier over the set of all refinements of a given model. As a variation on a bisimulation quantifier, this refinement operator or refinement quantifier ∀ can be seen as quantifying over a variable not occurring in the formula bound by it. The logic combines the simplicity of multi-agent modal logic with some powers of monadic second-order quantification. We present a sound and complete axiomatization of multi-agent refinement modal logic. We also present an extension of the logic to the modal μ -calculus, and an axiomatization for the single-agent version of this logic. Examples and applications are also discussed: to software verification and design (the set of agents can also be seen as a set of actions), and to dynamic epistemic logic. We further give detailed results on the complexity of satisfiability, and on succinctness. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

298. Deep learning in wastewater treatment: a critical review.

Author

Alvi, Maira, Batstone, Damien, Mbamba, Christian Kazadi, Keymer, Philip, French, Tim, Ward, Andrew, Dwyer, Jason, and Cardell-Oliver, Rachel

Subjects
*DEEP learning, *WASTEWATER treatment, *COMPUTER engineering, *BIOCHEMICAL models, *SEWAGE, *ARTIFICIAL intelligence
Abstract

Modeling wastewater processes supports tasks such as process prediction, soft sensing, data analysis and computer assisted design of wastewater systems. Wastewater treatment processes are large, complex processes, with multiple controlling mechanisms, a high degree of disturbance variability and non-linear (generally stable) behavior with multiple internal recycle loops. Semi-mechanistic biochemical models currently dominate research and application, with data-driven deep learning models emerging as an alternative and supplementary approach. But these modeling approaches have grown in separate communities of research and practice, and so there is limited appreciation of the strengths, weaknesses, contrasts and similarities between the methods. This review addresses that gap by providing a detailed guide to deep learning methods and their application to wastewater process modeling. The review is aimed at wastewater modeling experts who are familiar with established mechanistic modeling approach, and are curious about the opportunities and challenges afforded by deep learning methods. We conclude with a discussion and needs analysis on the value of different ways of modeling wastewater processes and open research problems. [Display omitted] • Process focused mechanistic models are widely used but are application specific. • Deep learning (DL) has applications in prediction, control, sensing, and data analytics. • DL is data-hungry and the lack of high-quality data sets is a key issue for training. • Improve training by transfer learning, and unfitted mechanistic models. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

299. Homologous Recombination Deficiency: Concepts, Definitions, and Assays.

Author

Stewart MD, Merino Vega D, Arend RC, Baden JF, Barbash O, Beaubier N, Collins G, French T, Ghahramani N, Hinson P, Jelinic P, Marton MJ, McGregor K, Parsons J, Ramamurthy L, Sausen M, Sokol ES, Stenzinger A, Stires H, Timms KM, Turco D, Wang I, Williams JA, Wong-Ho E, and Allen J

Subjects
BRCA1 Protein genetics, DNA Repair, Female, Homologous Recombination genetics, Humans, Poly(ADP-ribose) Polymerases genetics, Recombinational DNA Repair genetics, Ovarian Neoplasms drug therapy, Poly(ADP-ribose) Polymerase Inhibitors therapeutic use
Abstract

Background: Homologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to effectively repair DNA double-strand breaks using the homologous recombination repair (HRR) pathway. Loss-of-function genes involved in this pathway can sensitize tumors to poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapy, which target the destruction of cancer cells by working in concert with HRD through synthetic lethality. However, to identify patients with these tumors, it is vital to understand how to best measure homologous repair (HR) status and to characterize the level of alignment in these measurements across different diagnostic platforms. A key current challenge is that there is no standardized method to define, measure, and report HR status using diagnostics in the clinical setting., Methods: Friends of Cancer Research convened a consortium of project partners from key healthcare sectors to address concerns about the lack of consistency in the way HRD is defined and methods for measuring HR status., Results: This publication provides findings from the group's discussions that identified opportunities to align the definition of HRD and the parameters that contribute to the determination of HR status. The consortium proposed recommendations and best practices to benefit the broader cancer community., Conclusion: Overall, this publication provides additional perspectives for scientist, physician, laboratory, and patient communities to contextualize the definition of HRD and various platforms that are used to measure HRD in tumors., (© The Author(s) 2022. Published by Oxford University Press.)

Published
2022
Full Text
View/download PDF

300. Identification of biomarkers in human head and neck tumor cell lines that predict for in vitro sensitivity to gefitinib.

Author

Hickinson DM, Marshall GB, Beran GJ, Varella-Garcia M, Mills EA, South MC, Cassidy AM, Acheson KL, McWalter G, McCormack RM, Bunn PA, French T, Graham A, Holloway BR, Hirsch FR, and Speake G

Subjects
Antineoplastic Agents therapeutic use, Biomarkers, Tumor genetics, Cell Line, Tumor, DNA Mutational Analysis, Drug Resistance, Neoplasm genetics, Drug Screening Assays, Antitumor, Enzyme-Linked Immunosorbent Assay, Gefitinib, Gene Dosage genetics, Gene Expression Profiling, Gene Expression Regulation, Neoplastic drug effects, Genome, Human genetics, Humans, Neoplasm Proteins genetics, Neoplasm Proteins metabolism, Quinazolines therapeutic use, RNA, Messenger genetics, RNA, Messenger metabolism, Antineoplastic Agents pharmacology, Biomarkers, Tumor analysis, Drug Resistance, Neoplasm drug effects, Head and Neck Neoplasms genetics, Quinazolines pharmacology
Abstract

Potential biomarkers were identified for in vitro sensitivity to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib in head and neck cancer. Gefitinib sensitivity was determined in cell lines, followed by transcript profiling coupled with a novel pathway analysis approach. Eleven cell lines were highly sensitive to gefitinib (inhibitor concentration required to give 50% growth inhibition [GI(50)] < 1 microM), three had intermediate sensitivity (GI(50) 1-7 microM), and six were resistant (GI(50) > 7 microM); an exploratory principal component analysis revealed a separation between the genomic profiles of sensitive and resistant cell lines. Subsequently, a hypothesis-driven analysis of Affymetrix data (Affymetrix, Inc., Santa Clara, CA, USA) revealed higher mRNA levels for E-cadherin (CDH1); transforming growth factor, alpha (TGF-alpha); amphiregulin (AREG); FLJ22662; EGFR; p21-activated kinase 6 (PAK6); glutathione S-transferase Pi (GSTP1); and ATP-binding cassette, subfamily C, member 5 (ABCC5) in sensitive versus resistant cell lines. A hypothesis-free analysis identified 46 gene transcripts that were strongly differentiated, seven of which had a known association with EGFR and head and neck cancer (human EGF receptor 3 [HER3], TGF-alpha, CDH1, EGFR, keratin 16 [KRT16], fibroblast growth factor 2 [FGF2], and cortactin [CTTN]). Polymerase chain reaction (PCR) and enzyme-linked immunoabsorbant assay analysis confirmed Affymetrix data, and EGFR gene mutation, amplification, and genomic gain correlated strongly with gefitinib sensitivity. We identified biomarkers that predict for in vitro responsiveness to gefitinib, seven of which have known association with EGFR and head and neck cancer. These in vitro predictive biomarkers may have potential utility in the clinic and warrant further investigation.

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results