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309 results on '"Forst, H"'

301. [Acute lung failure--pathophysiology and therapeutic implications].

Author

Forst H, Kellermann W, Unertl K, and Peter K

Subjects
Humans, Pulmonary Alveoli physiopathology, Respiratory Distress Syndrome therapy, Risk Factors, Ventilation-Perfusion Ratio, Critical Care methods, Respiratory Distress Syndrome physiopathology
Published
1989

302. Lung tissue concentrations of ciprofloxacin following intravenous administration in patients.

Author

Forst H, Ruckdeschel G, Unertl K, Dieterich HJ, Ehret W, and Sunder-Plassmann L

Subjects
Adult, Aged, Chromatography, High Pressure Liquid, Ciprofloxacin administration & dosage, Ciprofloxacin pharmacokinetics, Female, Humans, Injections, Intravenous, Male, Middle Aged, Ciprofloxacin metabolism, Lung metabolism
Abstract

Serum and corresponding lung tissue concentrations of ciprofloxacin (Ciprobay) were investigated in 25 patients undergoing open lung surgery for pulmonary malignancies. Drug levels were measured at various times (50-240 min) after completion of a single i.v. dose of 200 mg by bioassay and HPLC. Lung tissue concentrations peaked within one hour after dosing (bioassay: 3.2 micrograms/g, HPLC: 4.5 micrograms/g). Tissue levels exceeded corresponding serum level 3- to 4fold throughout the observation period. The results demonstrate excellent penetration properties of this new antimicrobial compound into lung tissue. Ciprofloxacin was concentrated in the lung and thus by far exceeded known minimum inhibitory concentrations for most nosocomial respiratory pathogens.

Published
1989

303. [Large hormonally inactive adrenal cortical adenoma].

Author

Böcker R and Forst H

Subjects
Adult, Diagnostic Errors, Female, Humans, Radiography, Radioisotope Renography, Radionuclide Imaging, Adenoma diagnosis, Adenoma diagnostic imaging, Adenoma pathology, Adrenal Gland Neoplasms diagnosis, Adrenal Gland Neoplasms diagnostic imaging, Adrenal Gland Neoplasms pathology
Published
1973

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