Search

The purpose of this study was to determine the donor zone of most congruent topographic match by comparing 4 donor sites from the femur with 4 potential recipient sites of osteochondritis dissecans at the capitellum.Computed tomography was performed on 5 right elbows and 6 right medial and 6 right lateral distal femoral hemicondyles, which included the femoral notch. Three-dimensional computed tomography models were created and exported into point-cloud models. A local coordinate map of the distal humerus and distal femoral articular surfaces was created. The capitellum was compared with the medial and lateral distal femoral condyles, with 2 donor zones in each condyle (medial trochlea and medial intercondylar notch or lateral trochlea and lateral intercondylar notch). In each capitellum 4 combinations of 10-mm defects were simulated (central and lateral, 30° and 45° anterior to shaft of humerus), resulting in 480 capitellum-femur comparative combinations being tested. The capitellum surfaces were virtually placed on a point on the femoral articular surface in 3-dimensional space. The least distances (i.e., the shortest distance from the point in question to the corresponding point in space) between the point clouds on the distal humerus and distal femoral articular surfaces were calculated.There was a less than 0.1-mm difference in the topographic articular surface match among the 4 commonly used donor sites of the distal femur and 4 recipient sites of the capitellum. However, the best match for any given 10-mm capitellar defect (central 30°, central 45°, lateral 30°, and lateral 45°) was the same such that the lateral trochlea on the femur always yielded the best fit compared with the 3 other graft locations (P.005).Our results indicate that there is a less than 0.1-mm difference in the topographic articular surface match among the 4 commonly used donor sites of the distal femur and the capitellum. The findings suggest that all 4 donor sites provide close articular matching for the capitellum articular surface, with the lateral trochlea articular surface providing the best match.These data suggest that a single donor plug may be obtained from multiple sites in the knee and placed into capitellar lesions with an excellent topographic articular surface match. The findings of our study will be useful to surgeons when managing capitellar osteochondritis dissecans lesions.

The biomaterials are used for many biomedical applications. The main objective of the present work was to investigate the potential role of Bioglass (Melting)- Polyvinyl alcohol (BG (M)-PVA) and Bioglass (Melting)-Polyvinyl alcohol-20%Ciprofloxacin (BG (M)-PVA-20Cip) in regenerative bone capacity. These composites were implanted in the femoral condyles of Wistar rats and compared to that of ovariectomised groups. Our results noted, after the different period of implantation (15, 30, 60 and 90 days), that the Alkaline phosphatase (ALP) and Acid phosphatase (ACP) activities showed an excellent osteoinductive property of BG (M)-PVA, that this phenomena decreased with the presence of ciprofloxacin. Physico-chemical techniques (ICP-OES and SEM) were engaged to highlight the influence of antibiotic on the structure, porosity and bioactivity of a porous Glass-PVA before and after implantation. The results obtained by ICP-OES showed a rapid reduction in silicon (Si) and sodium (Na), and noted an accelerator increase in calcium (Ca) and phosphorus (P) ion concentrations in BG (M)-PVA that the BG (M)-PVA-20Cip. This result is confirmed by SEM. We can conclude that the loading of ciprofloxacin in BG (M)-PVA is characterized by a retard effect of formation of apatitic phase.

Introduction Autogenous osteochondral mosaicplasty is the most common cartilage restoration technique in standard clinical practice. The purpose of this study was to evaluate the return to sports 9 years after mosaicplasty of the femoral condyles. Hypothesis The long-term results of an osteochondral autograft show that patients can regain their pre-injury activity level. Material and methods This study is based on a series of 25 patients with a mean age of 28.9 years (range, 16–44 years) who had stage 3 or 4 chondral lesions of the femoral condyles (according to the ICRS or ICRS-OCD scores). The origin of the lesion was osteochondritis dissecans (13 knees), osteochondral fracture sequelae (ten knees), or aseptic osteonecrosis (two knees). The average size of the lesion was 2.11 ± 0.9 cm2. Ten patients (40%) had an associated procedure during the osteochondral autograft. The patients were assessed clinically (IKDC and Lysholm-Tegner scores) and radiographically by a reviewer independent of the team of operators. Results All patients were re-examined at a mean follow-up of 9 years (range, 6–15 years), with 84% satisfied or very satisfied with the procedure. The average IKDC was 74.5 ± 18.5 points. The average Lysholm score was 87.3 ± 11.6 points. The average Tegner score ranged from 6.35 ± 1.53 points prior to surgery to 5.60 ± 1.64 points after surgery (P = 0.001). The average loss was 0.64 points for patients whose presurgery Tegner score was greater than or equal to 7 (P = 0.019) and 0.3 points if lower than 7. The radiologic evaluation of 21 patients showed complete osteointegration of the grafts in 90% of cases. Conclusion The results of the femoral condyle mosaic autografts are satisfactory, a mean of 9 years after surgery. The most active patients lowered their activity level while the more sedentary did not have to adapt their lifestyle. Level of evidence Level IV, retrospective study.

HHS Public Access Author manuscript Author Manuscript J Magn Reson Imaging. Author manuscript; available in PMC 2016 December 01. Published in final edited form as: J Magn Reson Imaging. 2015 December ; 42(6): 1507–1516. doi:10.1002/jmri.24936. Normal T2 map profile of the entire femoral cartilage using an angle/layer dependent approach Yasuhito Kaneko, MD, PhD 1 , Taiki Nozaki, MD 1 , Hon Yu, PhD 2 , Andrew Chang, MD 1 , Kayleigh Kaneshiro, MD 1 , Ran Schwarzkopf, MD 3 , Takeshi Hara, PhD 4 , and Hiroshi Yoshioka, MD, PhD 1 Author Manuscript Yasuhito Kaneko: yasuhitk@uci.edu; Taiki Nozaki: nozakit@uci.edu; Hon Yu: hjyu@uci.edu; Andrew Chang: andrelc1@uci.edu; Kayleigh Kaneshiro: kkaneshi@uci.edu; Ran Schwarzkopf: schwarzk@uci.edu; Takeshi Hara: takeshi.hara@mac.com; Hiroshi Yoshioka: hiroshi@uci.edu 1 Department of Radiological Sciences, University of California, Irvine, Orange, California 2 John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California, Irvine, Orange, California 3 Department of Orthopaedic Surgery, University of California, Irvine, Orange, California 4 Department of Intelligent Image Information, Division of Regeneration and Advanced Medical Sciences, Gifu University Graduate School of Medicine, Gifu, Japan Abstract Author Manuscript Purpose—To create standard T2 map profiles from the entire femoral cartilage of healthy volunteers in order to assess for regional variations using an angular and layer dependent approach. Materials and Methods—Twenty healthy knees were evaluated using 3T sagittal images of a T2 mapping sequence. Manual segmentation of the entire femoral cartilage was performed slice by slice by two raters using Matlab. Inter- and intra-rater reliabilities were calculated using intraclass correlation coefficient (ICC) and Bland-Altman analysis. T2 values were analyzed with respect to specific locations (medial condyle, trochlea, and lateral condyle), angles to B 0 , and layers of cartilage (whole, deep, and superficial). Author Manuscript Results—Inter- and intra-rater reliability obtained from entire femoral cartilage was excellent (ICC = 0.84, 0.86, respectively). The ICCs around the trochlea were lower than those of the medial and lateral condyle. Both the inter- and intra-rater Bland-Altman plots indicated larger differences in pixel count are seen as the size of the angular segment becomes larger. T2 values were significantly higher in the superficial layer compared to the deep layer at each femoral compartment (p < 0.001). Magic angle effect was clearly observed, especially within the whole and deep layer over the medial and lateral femoral condyles, except for the superficial layer at the medial condyle. Address correspondence and reprint request to: Hiroshi Yoshioka, MD, PhD, Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Rt. 140, Orange, CA 92868, Phone: (714) 456-8849, FAX: (714)456-7430, hiroshi@uci.edu.

Numerous studies have reported on in-vivo posterior femoral condyle translations during various activities of the knee. However, no data has been reported on the knee motion during a continuous flexion-extension cycle. Further, few studies have investigated the gender variations on the knee kinematics. This study quantitatively determined femoral condylar motion of 10 male and 10 female knees during a continuous weightbearing flexion-extension cycle using two-dimensional to three-dimensional fluoroscopic tracking technique. The knees were CT-scanned to create three-dimensional models of the tibia and femur. Continuous images of each subject were taken using a single-fluoroscopic imaging system. The knee kinematics were measured along the motion path using geometric center axis of the femur. The results indicated that statistical differences between the flexion and extension motions were only found in internal-external tibial rotation and lateral femoral condylar motion at the middle range of flexion angles. At low flexion angles, male knees have greater external tibial rotation and more posteriorly positioned medial femoral condyle than females. The knee did not show a specific pivoting type of rotation with flexion. Axial rotation center varied from lateral to medial compartments of the knee. These data could provide useful information for understanding physiological motion of normal knees.

Aim: The purpose of this study was to assess the difference of removal torque values (RTV) and the bone-to-implant contact (BIC) between the sand-blasted, large grit, and acid-etched (SLA) surface-treated and the machined surface (MA) miniscrews. Material and methods: Miniscrews used in this study were 6mm long with a diameter of 1.5mm. A total of 23 SLA miniscrews and 24 MA miniscrews were placed into the distal femoral condyle of 24 New Zealand rabbits. Removal torque test and the BIC was histologically evaluated at 0 and 8 weeks. Results: There was no statistical difference between the RTV in the MA group versus the SLA group at both 0 and 8 weeks. Comparing 0–8 weeks, there was no significant difference in RTV of the SLA group ( P = 0.48), however the change in the MA group was statistically significant ( P = 0.006). Histological observation showed a significant decrease in BIC comparing 0 and 8 weeks for the MA group. The BIC ratio at 8 weeks was statistically significantly higher in the SLA group compared to the MA group. Conclusion: SLA surface preparation does not increase the RTV of miniscrews. Further investigations under loading and a large sample size are required.

Anterior cruciate ligament (ACL) injury causes knee joint instability, and effects on sports performance. Therefore, ACL reconstruction is essential to keep their high performance. It is well known that the outcome of ACL reconstruction is strongly related to the placement and orientation of the bone tunnel. Therefore, optimization of tunnel drilling technique is an important factor to obtain satisfactory surgical results. Current procedure relies on arthroscopic evaluation and there is a risk of damaging arteries and ligaments during surgery. The damages may reduce the accuracy and reproducibility of ACL reconstruction. As a postoperative evaluation method, a quadrant method has been used to evaluate the placement and orientation of the bone tunnel in X-ray radiography. This study proposes a computer-aided surgical planning system for evaluating ACL insertion site and orientation using magnetic resonance (MR) images. We first introduce MR image based the quadrant method to determine the ACL insertion site for preoperative patients. It also evaluates the 3-D spatial relationship between the planning femoral drilling hole and arteries around the femoral condyle. This system has been applied to ACL injured patients, it may increase the accuracy and reproducibility of ACL bone tunnel, and it can evaluate a risk of damaging the surrounding arteries and ligaments.

Currently, an anteroposterior radiograph of the knee is judged based on a centered position of the patella between the femoral condyles. We are not aware of any anatomic literature supporting this recommendation.Orthogonal images are required for accurate assessment of knee deformity. Although an image with the patella centered at the distal femur is generally accepted as a true anteroposterior (AP) radiograph of the knee, there is minimal anatomic data to support that this view is orthogonal to a true lateral view of the knee where the condyles are overlapped. We designed an anatomical study to test the relationship between these two radiographic views.We studied 428 well-preserved cadaveric skeletons ranging from 40 to 79 years of age at death. Centering of the patella was calculated based on distal femoral and patellar widths. Multiple regression analysis was then performed to determine the relationship between patellar centering and age, gender, ethnicity, mechanical lateral distal femoral angle (mLDFA), medial proximal tibial angle (MPTA), femoral anteversion, and contralateral centering.Average patellar centering was 0.13 ± 0.04, indicating that the average patella was laterally positioned in the distal femur. Only mLDFA and contralateral centering showed statistically significant independent correlations with patellar centering with modest standardized beta coefficients of 0.10 and 0.23, respectively.In the average specimen, the patella is laterally deviated by 13% of the condylar width. Clinicians should be aware that a lateral view with the femoral condyles overlapped is not always orthogonal to a patella-centered AP view when planning and implementing deformity correction.

Osteochondral defects are a significant clinical challenge for orthopaedic surgeons. Patients often experience swelling, clicking, pain, and at times, a feeling of instability. Although some low-demand patients can be adequately managed with nonoperative treatments, active, young patients or older patients with a higher activity level often benefit from surgical intervention for symptomatic lesions. Several surgical therapies exist to treat symptomatic cartilage injuries. Osteochondral autograft transplantation, or mosaicplasty, is an effective treatment for cartilage lesions ranging from 1-5cm 2 . Healthy osteochondral plugs are harvested from the non–weight-bearing areas of the superolateral or superomedial femoral condyles and used to fill the cartilage defect. This provides replacement of congruent hyaline cartilage into a focal defect without the need for cartilage growth, allograft, or synthetic tissue. The procedure is technically demanding, but in the appropriate patient population, several series have had good to excellent results in the medium to long term.

Introduction Congenital dislocation of the knee (CDK) is rare, and clinical semiology at birth is not always suitably analyzed. Existing classifications fail to guide treatment. The aim of the present study was to develop a CDK classification for the neonatal period. Hypothesis A classification based on neonatal severity of clinical signs is easy to implement on simple criteria. Material and methods Fifty-one CDKs (40 patients) seen neonatally were included. Three types could be distinguished in terms of reduction and stability: type I, easily reducible CDK, with reduction snap when the femoral condyles pass in flexion, remaining stable in flexion; type II, “recalcitrant” dislocation, reducible by posteroanterior “piston” but unstable, with iterative dislocation once posteroanterior pressure on the condyles is relaxed; and type III, irreducible. The number of anterior skin grooves, global range of motion, flexion deficit and reduction stability were noted for each type. Results Mean age at first consultation was 5.6 days (range: 0–30). CDK was type I, II and III in respectively 28, 16 and 7 cases. Number of skin grooves, flexion and baseline range of motion were greater in type I than types II and III. Conclusion The present neonatal clinical classification is original, logical and simple. It may be useful for prognosis and guiding treatment. Level of evidence IV, single-center retrospective series.

Articular cartilage defects at the knee joint are being identified and treated with increasing frequency. Chondrocytes may have strongest potential to generate high-quality repair tissue within the defective region, in particular when large diameter defects are present. Autologous chondrocyte implantation is not available in every country. We present a case where we spontaneously covered an acute cartilage defect, which was significantly larger than expected and loose during initial arthroscopic inspection after reading preoperative MRI, by mincing the separated fragment and directly implanting the autologous cartilage chips into the defective region.

Bone morphology is one feature that contributes to knee kinematics. The geometry of the tibia and femur vary across individuals, and these differences can influence the risk of anterior cruciate ligament (ACL) injury and of failure after isolated ACL reconstruction. There has been renewed interest in lateral extra-articular stabilization procedures to supplement an ACL reconstruction, although which patients benefit most from these procedures remains unclear. This article reviews the impact of bone morphology on knee kinematics, including tibial slope, depth of the medial tibial plateau, intercondylar notch shape, tibial eminence volume, and sphericity of the femoral condyles.

Periarticular avascular osteonecrosis is one of the most severe joint diseases and may result in complete joint destruction. It may affect patients after chemotherapy involving regimens including steroids. The paper describes the case of a female patient who was just under 18 years old when she underwent surgery due to bilateral osteonecrosis of the femoral condyles that developed in the course of treatment of a haematological malignancy. The aim of the paper is to present clinical and imaging-based assessment of the outcome of surgical treatment by reconstruction of osteochondral joint defects with a collagen membrane and bone grafts. In this patient, radiographic and clinical improvement of the joints treated was noted in a 24-month follow-up period. The available literature indicates that this is the first example of using this technique in the treatment of articular lesions associated with osteonecrosis caused by aggressive chemotherapy. The so-called “sandwich” technique is useful in these cases and may be recommended by the present authors.

Lesões osteocondrais (LOC) secundárias a luxações patelo-femorais são uma entidade clínica cuja incidência diagnóstica está a aumentar drasticamente com o advento da artroscopia e da ressonância magnética nuclear (RMN). Envolvem preferencialmente a faceta medial da rótula e zona medial ao sulco terminalis do côndilo femoral externo, sendo raro o envolvimento da zona de carga. O diagnóstico precoce é fundamental para a preservação da cartilagem saudável, contudo não é invulgar o seu atraso, motivado pela clínica não específica de entorse do joelho e exames complementares diagnósticos disponíveis no Serviço de Urgência sem alterações patológicas. Perante a suspeita de LOC torna-se necessária a realização de RMN para confirmação do diagnóstico e orientação terapêutica. O tratamento de eleição desta entidade consiste na fixação ou remoção dos fragmentos osteocondrais , a qual pode ser artroscópica ou por cirurgia aberta através de mini-artrotomia Incisão longitudinal ao longo das linhas de forças da pele com 3 cm de comprimento a alargar o portal de artroscopia para melhor permitir o posicionamento dos pinos). Dadas as suas vantagens e a publicação de resultados promissores, a artroscopia do joelho e os materiais reabsorvíveis têm ganho um papel cada vez mais central no tratamento desta entidade. O ortopedista pediátrico envolvido no tratamento das instabilidades do aparelho extensor deve estar atento a este padrão lesional incomum de forma a assegurar o seu diagnóstico e terapêutica adequados. Os autores descrevem um caso de fratura osteocondral da zona de carga do côndilo femoral externo submetida a redução anatómica e fixação com pinos reabsorvíveis através de mini-artrotomia sob controlo artroscópico. A paciente apresentou boa evolução clínica, com consolidação e regresso ilimitado sem limitações à atividade desportiva. Osteocondral fractures sustained during acute patella dislocations are becoming an increasingly more common diagnosis with the growing importance of arthroscopy and MRI. These injuries frequently involve the medial patellar margin and the non-weight-bearing portion of the lateral trochlear margin. However osteochondral fractures involving the weight-bearing portion of the lateral femoral condyle are rare. Early diagnosis is key in preserving the remaining healthy cartilage, however delayed diagnosis is not uncommon, due to unspecific clinical presentation of knee sprain and the imaging techniques available in the emergency department. When suspecting an osteocondral fracture it is mandatory to perform an MRI for diagnostic confirmation and preoperative planning. The available treatment of choice of these rare fractures include osteosynthesis or excision with surgical debridement, either arthroscopically or through a small arthrotomy. Given their advantages and recent publication of promising results, arthroscopic fixation and bioabsorbable materials are becoming increasingly popular in the treatment of osteocondral fractures. Paediatric orthopaedic surgeons involved in the treatment of patellar instabilities should be aware of this unusual complication to assure its timely diagnosis and adequate treatment. The authors report a case of an osteochondral fracture involving the weight-bearing surface of the lateral condyle managed with mini-open reduction and bioabsorbable pin fixation under arthroscopic control, and resulting in successful clinical and radiographic results. Osteocondral healing was confirmed and the patient returned to sports without limitations.

The distal end of the femur has immense importance from the anatomical, functional and clinical point of view. The present study was carried out to assess the individual condylar dimension, maximum bicondylar width, size of intercondylar notch and bicondylar angle on dry femurs and on digital radiographic plates among the population of eastern India. The study was carried out bilaterally on seventy adult dry femurs of unknown sex and also on fifty digital radiographic plates of known age and sex by using Martin’s sliding calipers, diaptograph and sigma view software. Among the different parameters, transverse and vertical dimensions of medial condyle and intercondylar width showed significant bilateral asymmetry. From radiologic evaluation, it has been observed that only bicondylar width showed sexual dimorphism on both sides. The present study also reported significant asymmetry in bicondylar width between the two sides in males but not in females, whereas comparison of bicondylar angle between right and left sides revealed significant difference in females in contrast to males. The present study may help in manufacturing a properly sized implant and also help the surgeons during instrumentation of lower end of femur., Italian Journal of Anatomy and Embryology, Vol 122, No 1 (2017)

To assess whether the use of cartilaginous contours at the femoral condyles instead of bony contours significantly changes femoral torsion measurements in children.Femoral torsion was measured in 32 girls (mean age 10.1 years±2.3 standard deviation) and 42 boys (10.9 years±2.5) on axial magnetic resonance (MR) images by two independent readers (R1,R2). The femoral condyle angle was measured using each the cartilaginous and bony contours of the distal femur. Cartilage thickness at femoral condyles was assessed. Intraclass-correlation-coefficient (ICC) and Pearson's correlation were used for statistical analysis.Mean difference between cartilaginous and bony femoral torsion in girls was -1.1°±1.75 (range, -5.4° to 3.1°) for R1 and -1.64°±1.67 (-6.3° to 2.1°) for R2, in boys -1.5°±1.87 (-8.4° to 1.1°) for R1 and -2.28°±1.48 (-4.3° to 9.7°) for R2. Weak-to-moderate correlations between difference of cartilaginous-versus-bony measurements and cartilage thickness (r=-0.15 to -0.55, P0.001-0.46) or age (r=-0.33 to 0.46, P0.001-0.006) were found for both genders. Intermethod-ICC for cartilaginous versus bony femoral torsion measurements was 0.99/0.99 for R1/R2 in girls, and 0.99/0.98 in boys.There is only a small difference when measuring femoral torsion through cartilaginous versus bony contours, and no major difference in this between boys and girls.

The purpose of our study was to investigate the antibacterial effect of a spacer (Ti6Al4V) coated with 4x Cu-TiO₂ in an animal model simulating an acute periprosthetic infection by Staphylococcus aureus. Ti6Al4 bolts contaminated with Staphylococcus aureus were implanted into the femoral condyle of rabbits (n = 36) divided into 3 groups. After one week in group 1 (control) the bolts were removed without any replacement. In group2 Ti6Al4V bolts with a 4x Cu-TiO₂ coating and in group 3 beads of a gentamicin-PMMA chain were imbedded into the borehole. Microbiological investigation was performed at the primary surgery, at the revision surgery and after scarification of the rabbits 3 weeks after the first surgery. Blood tests were conducted weekly. The initial overall infection rate was 88.9%. In group 2 and 3 a significant decrease of the infection rate was shown in contrast to the control group. The C-reactive protein (CRP) levels declined one week after the first surgery except in the control group where the CRP level even increased. This is the first in vivo study that demonstrated the antibacterial effects of a fourfold Cu-TiO₂ coating. For the future, the coating investigated could be a promising option in the treatment of implant-associated infections.

Background The positions of unicompartmental femoral components do not always follow the neutral center of the medial distal femoral condyle. The biomechanical effect of the center of the distal femoral condyle has not yet been evaluated, and the optimal femoral position in unicompartmental knee arthroplasty (UKA) is yet to be biomechanically justified. The purpose of this study was to evaluate, using finite element analysis, the effect of the center of the distal femoral component on the biomechanical outcomes of UKA with respect to the contact stresses in the polyethylene (PE) insert and articular cartilage. Methods Five models in which the centers of the distal femoral components were translated by three millimeters and five millimeters to the medial and lateral sides, respectively, from the neutral position were modeled and analyzed in a gait loading condition. Results The contact stresses on the PE insert increased as the center of the femoral component translated to the lateral side and, in contrast, the contact stresses decreased as it translated to the medial side. For the articular cartilage the contact stresses increased and decreased as the center of the femoral component translated to the medial and lateral sides. Conclusion This study implied that the best position for the femoral component in UKA could be the center of the distal femoral condyle. Femoral component position could be one of the sensitive factors that influenced the contact stresses on the PE insert and articular cartilage, and the postoperative significance of the femoral component position in UKA.

Surgical strategies for knee joint preservation are numerous, with the procedure(s) of choice for a given patient dependent on the status of the articular cartilage, meniscus, overall alignment, and ligamentous stability. For patients with large, isolated, osteochondral defects of the articular cartilage of the femoral condyle, osteochondral allograft transplantation (OCA) is often performed in an effort to reduce pain and improve function. Similarly, for appropriately indicated patients with symptomatic meniscus deficiency, meniscus allograft transplantation (MAT) is an excellent surgical solution. Often patients require concomitant MAT and OCA as part of a joint preservation strategy. In this Technical Note, we describe the surgical technique for performing arthroscopic-assisted concomitant lateral MAT and lateral femoral condyle OCA as part of a knee joint preservation strategy.

The purpose of this study was to reveal the correlation between femoral tunnel length and the morphology of the femoral intercondylar notch in anatomical single bundle anterior cruciate ligament (ACL) reconstruction using three-dimensional computed tomography (3D-CT). Thirty subjects undergoing anatomical single bundle ACL reconstruction were included in this study (23 female, 7 male: average age 45.5 ± 16.7). In the anatomical single bundle ACL reconstruction, the femoral and tibial tunnels were created close to the antero-medial bundle insertion site with trans-portal technique. Using post-operative three-dimensional computed tomography (3D-CT), accurate axial and lateral views of the femoral condyle were evaluated. The correlation of femoral tunnel length, which was measured intra-operatively, with the transepicondylar length (TEL), notch width index, notch outlet length, the notch area (axial), length of Blumensaat’s line, and the height and area of the lateral wall of the femoral intercondylar notch was statistically analyzed. Tunnel placement was also evaluated using a Quadrant method. The average femoral tunnel length was 35.4 ± 4.4 mm. The average TEL, NWI, notch outlet length, and the axial notch area, were 76.9 ± 5.1 mm, 29.1 ± 3.8%, 19.5 ± 3.9 mm, and 257.4 ± 77.4 mm2, respectively. The length of Blumensaat’s line and the height and area of the lateral wall of the femoral intercondylar notch were 33.8 ± 3.2 mm, 22.8 ± 2.3 mm, and 738.7 ± 129 mm2, respectively. The length of Blumensaat’s line, the height, and the area of the lateral wall of the femoral intercondylar notch were significantly correlated with femoral tunnel length. Femoral tunnel placement was 23.4 ± 4.5% in a shallow-deep direction and 35.4 ± 8.8% in a high-low direction. The length of Blumensaat’s line, height, and area of the lateral wall of the femoral intercondylar notch are correlated with femoral tunnel length in anatomical single bundle ACL reconstruction. For clinical relevance, these parameters are useful in predicting the length of the femoral tunnel in anatomical single bundle ACL reconstruction for the prevention of extremely short femoral tunnel creation. Case controlled study, Level III.

Background:Unicompartmental knee arthroplasty (UKA) is an effective treatment option for medial compartment osteoarthritis (OA) of the knee. Whether spontaneous osteonecrosis of the knee (SPONK) can be successfully treated with UKA remains controversial. This study evaluated the clinical and radiological results of patients with SPONK who were treated by UKA using Oxford phase III prostheses.Methods:We compared a prospective series of 23 UKA cases operated for SPONK with 235 UKA cases operated for OA. All patients underwent Magnetic Resonance Imaging (MRI) to confirm the diagnosis and exclude any major lesion in the lateral compartment. The stage, condylar ratio, and volume of the necrotic lesion were evaluated. The pre and postoperative Oxford knee scores (OKSs) were compared.Results:The mean follow-up was 60 months. No statistical differences in complication rates between the groups were found. The mean OKS improved from 39.48 ± 5.69 to 18.83 ± 3.82 ( p < 0.05). There were no significant differences in the pre and postoperative OKS between the different groups.Conclusion:SPONK can be successfully treated with UKA, with a favorable short- to mid-term follow-up.

The meniscus is a fibro-cartilaginous tissue located between the femoral condyles and the tibial plateau in the knee. The presence of the meniscus tissue is vital for the proper function of the knee. Meniscal injuries are very frequent cases in the orthopaedics, and they have limited self-healing capacity. The importance of the basic science of meniscus has been acknowledged for the meniscus development of regenerative strategies, and the knowledge is increasing over time. Herein, the biology, anatomy, and biochemistry of meniscus tissue are overviewed.

A 21-year-old man presented to the clinic with long-standing problems with both knees. From the age of 7 years old, he had had pain and stiffness in his knees. He gave up soccer at the age of 12 years and martial arts at the age of 14 years; the latter following a number of falls directly onto his knee. At the age of 14, he dislocated his left patella. His left knee was never been normal after that. His right knee had been a problem over the previous 2 years with recurrent patellar dislocations.

To investigate how surgically created acute full-thickness cartilage defects of similar size and location created on the medial versus lateral femoral condyle influence progression of spontaneous cartilage lesions in a rat model. Full-thickness cartilage defects of 1 mm were surgically created on the medial or lateral femoral condyles on the right leg of 20 rats (n = 10/group). Ten rats served as controls. Spontaneous lesion progression on the ipsilateral and contralateral surfaces was examined using a high-resolution digital camera along with H&E and Safranin-O staining. Chondral defects were scored grossly and histologically. Control femur displayed no cartilage disruption. Surgically treated knees exhibited created and spontaneous cartilage defects with no evidence of healing unless subchondral bone was penetrated. Ipsilateral spontaneous lesions on the lateral condyle were significantly more severe on average (p = 0.009) compared to medial lesions on gross examination. Histological examination found contralateral lesions on the lateral surface following surgically created medial lesions to be more severe (p = 0.057) compared to contralateral lesions. A trend toward more susceptible chondral damage to the lateral condyle was observed following acute lesion creation on either medial or lateral condyles. Mechanisms behind this pattern of spontaneous lesion development are unclear, requring further investigation.

The purpose of this article is to provide a review of coronal fractures of the femoral condyles, known as Hoffa fractures. This includes a review of the normal anatomy of the femoral condyles, examples of the injury, and postoperative imaging findings after surgical treatments. Knowledge of anatomy with related pathology, orthopedic trends, imaging findings, and complications, is important in assessing Hoffa fractures.

Summary Objective To compare the 2D and 3D MOCART system obtained with 9.4 T high-field magnetic resonance imaging (MRI) for the ex vivo analysis of osteochondral repair in a translational model and to correlate the data with semiquantitative histological analysis. Methods Osteochondral samples representing all levels of repair (sheep medial femoral condyles; n = 38) were scanned in a 9.4 T high-field MRI. The 2D and adapted 3D MOCART systems were used for grading after point allocation to each category. Each score was correlated with corresponding reconstructions between both MOCART systems. Data were next correlated with corresponding categories of an elementary (Wakitani) and a complex (Sellers) histological scoring system as gold standards. Results Correlations between most 2D and 3D MOCART score categories were high, while mean total point values of 3D MOCART scores tended to be 15.8–16.1 points higher compared to the 2D MOCART scores based on a Bland–Altman analysis. "Defect fill" and "total points" of both MOCART scores correlated with corresponding categories of Wakitani and Sellers scores (all P ≤ 0.05). "Subchondral bone plate" also correlated between 3D MOCART and Sellers scores ( P Conclusions Most categories of the 2D and 3D MOCART systems correlate, while total scores were generally higher using the 3D MOCART system. Structural categories "total points" and "defect fill" can reliably be assessed by 9.4 T MRI evaluation using either system, "subchondral bone plate" using the 3D MOCART score. High-field MRI is valuable to objectively evaluate osteochondral repair in translational settings.

Introduction :The rationale for operative treatment of depressed tibial plateau fractures is anatomic reduction, stable fixation and grafting. Grafting options include autogenous bone graft or bone substitutes.Methods :The autograft group included 18 patients with depressed tibial plateau fractures treated with autogenous bone grafting from the ipsilateral femoral condyle following open reduction and internal fixation. According to Schatzker classification, there were 9 type II, 4 type III, 2 type IV and 3 type V lesions. The average time to union and the hospital charges were compared with the bone substitute group. The latter included 17 patients who had an excellent outcome following treatment of split and/or depressed lateral plateau fractures, using a similar surgical technique but grafting with bone substitutes (allografts).Results :Excellent clinical and radiological results were detected in the autograft group after an average follow-up of 28 months (range 12-37). The average time to union in the autograft group was 14 weeks (range 12-16), while in the bone substitute group it was 18 weeks (range 16-20). The mean total cost was 1276 Euros for the autograft group and 2978 Euros for the bone substitute group.Discussion :The use of autogenous graft from the ipsilateral femoral condyle following open reduction and internal fixation of depressed tibial plateau fractures provided enough bone to maintain the height of the tibial plateau and was not associated with any donor site morbidity. Using this method, the surgical time was not significantly elongated and the rehabilitation was not affected. It also exhibited faster fracture healing without postoperative loss of reduction and it was less expensive than the use of bone substitutes.

Osteochondritis dissecans (OCD) is a disorder resulting in focal breakdown of the subchondral bone, with potential disruption of the overlying articular cartilage. The femoral condyles of the knee are the most common locations for OCD, and the incidence of OCD appears to be increasing among active children. Juvenile OCD (JOCD) can be distinguished from adult OCD by the presence of open growth plates. Due to a lack of evidence on its early diagnosis, optimal treatment, and long-term course of healing, JOCD presents a unique challenge for the health care team. Approximately 50% to 67% of stable JOCD lesions heal successfully with nonoperative treatment. For unstable lesions and stable lesions that fail nonoperative treatment, a variety of surgical interventions can be utilized to stimulate bony healing and address articular cartilage lesions. It is recommended that rehabilitation of JOCD be tailored to the individual patient, based on the stage and radiographic status of the lesion and the mode of surgery employed when surgically addressed. Although there is a growing body of literature on this condition, the etiology and optimal methods for treatment, rehabilitation, and evaluating outcomes remain inconclusive due to a lack of quality evidence.Therapy, level 5.

Background: Matrix-induced autologous chondrocyte implantation (MACI) is an established technique for the repair of knee chondral defects, although the correlation between clinical and radiological outcomes after surgery is poorly understood. Purpose: To determine the correlation between clinical and radiological outcomes throughout the postoperative timeline to 5 years after MACI. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: This retrospective study was undertaken in 83 patients (53 male, 30 female) with complete clinical and radiological follow-up at 1, 2, and 5 years after MACI. The mean age of patients was 38.9 years (range, 13-62 years), with a mean body mass index (BMI) of 26.6 kg/m2 (range, 16.8-34.8 kg/m2), mean defect size of 3.3 cm2 (range, 1-9 cm2), and mean preoperative duration of symptoms of 9.2 years (range, 1-46 years). Patients indicated for MACI in this follow-up were 13 to 65 years of age, although they were excluded if they had a BMI >35 kg/m2, had undergone prior extensive meniscectomy, or had ongoing progressive inflammatory arthritis. Patients were assessed clinically using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Magnetic resonance imaging (MRI) was used to evaluate the graft using a 1.5-T or 3-T clinical scanner; the MRI assessment included 8 parameters of graft repair (infill, signal intensity, border integration, surface contour, structure, subchondral lamina, subchondral bone, and effusion) based on the magnetic resonance observation of cartilage repair tissue (MOCART) score as well as an MRI composite score. The degree of an association between the MRI parameters and the KOOS subscales at each postoperative time point was assessed with the Spearman correlation coefficient (SCC), and significance was determined at P < .05. Ethics approval was obtained from the appropriate hospital and university Human Research Ethics Committees, and informed consent was gathered from all patients. Results: The only MRI parameter displaying consistent evidence of an association with the KOOS subscales was effusion, with a pattern of increasing strength of correlations over time and statistically significant associations at 5 years with KOOS-Pain (SCC, 0.25; P = .020), KOOS–Activities of Daily Living (SCC, 0.26; P = .018), and KOOS-Sport (SCC, 0.32; P = .003). Apart from a significant correlation between subchondral lamina and KOOS-Sport at 1 year (SCC, 0.27; P = .016), no further significant findings were observed. Conclusion: Apart from some consistent evidence of an association between the KOOS and effusion, this analysis demonstrated a limited correlative capacity between clinical and radiological outcomes up to 5 years after surgery.

Near-Infrared Spectroscopy (NIRS) could be of clinical relevance in modern cartilage regeneration.In a miniature pig model correlation of measurements and histologic scores have never been used before. The data analysis was part of an animal project that investigated the effects of seeding a chondrogenic and osteogenic scaffold with a bone-marrow-derived cell concentrate and reports the histological and mechanical properties. We created 20 osteochondral defects in the femoral condyles of 10 miniature pigs.The defects were left empty (E), filled with the grafted cylinder upside down (U), or with a combined scaffold (S) containing a spongy bone cylinder covered with a collagen membrane. In the fourth group, the same scaffolds were implanted but seeded with a stem cell concentrate (S+BMCC). The animals were euthanized after 3 months, and histologic and spectrometric analyses were performed. NIRS measurements were significantly higher in the central area of the defects of group S+BMCC compared to the central area of the defects of group U. In all groups, a correlation between NIRS and the histologic scores could be demonstrated though on different levels. In the central area, a good NIRS measurement correlates with low (good) histologic scores. In group E and group S, this negative correlation was significant (p=0.01). For the first time, NIRS was successfully used to evaluate osteochondral constructs in a miniature pig model.

This study investigates the effects of seeding a chondrogenic and osteogenic scaffold with a bone marrow-derived cell concentrate (BMCC) and reports the histological and mechanical properties 3 months after implantation in the miniature pig. Twenty defects (7×10 mm) were created in the femoral condyles of 10 miniature pigs. The defects were left empty (E), filled with the grafted cylinder upside down (U) or with a combined scaffold (S) containing a spongious bone cylinder (Tutobone®) covered with a collagen membrane (Chondrogide®). In a fourth group, the same scaffolds were implanted but seeded with a stem cell concentrate (S+ BMCC). The animals were stained with calcein green after 2 weeks and xylenol orange after 4 weeks. After 3 months, the animals were sacrificed, and a mechanical analysis (Young's modulus), macroscopic, and histologic (ICRS Score) examination of the specimens was conducted. Young's modulus in the periphery was significantly lower for group E (67.5±15.3 kPa) compared with untreated controls (171.7±21.6 kPa, p0.04). Bone defects were smaller in group S (10%±8%) compared with E (27%±7%; p0.05). There was a trend toward smaller bony defects on comparing groups E and S+ BMCC (11%±8%; p=0.07). More red fluorescence was detected in group S+ BMCC (2.3%±1.1%) compared with groups E (0.4%±0.2%) and U (0.5%±0.2%, p0.03). ICRS scores were higher for groups S (25.3±3.8) and S+ BMCC (26.2±5.2, p0.01). In this animal model of osteochondral defects, stem cell concentrates enhance new bone apposition but fail to improve mechanical properties or histological appearance of cartilage regenerates in critical-sized defects.

Efforts to compare different surface marker configurations in 3-dimensional motion analysis are warranted as more complex and custom marker sets become more common. At the knee, different markers can been used to represent the proximal shank. Often, two anatomical markers are placed over the femoral condyles, with their midpoint defining both the distal thigh and proximal shank segment ends. However, two additional markers placed over the tibial plateaus have been used to define the proximal shank end. For this experiment, simultaneous data for both proximal shank configurations were independently collected at two separate laboratories by different investigators, with one laboratory capturing a walking population and the other a running population. Common discrete knee joint variables were then compared between marker sets in each population. Using the augmented marker set, peak knee flexion after weight acceptance was less (1.2−1.7°, P < .02) and peak knee adduction was greater (0.7−1.4°, P < .001) in both data sets. Similarly, the calculated peak knee flexion moment was less by 15–20% and internal rotation moment was greater by 11–18% (P < .001). These results suggest that the calculation of knee joint mechanics are influenced by the proximal shank’s segment endpoint definition, independent of dynamic task, investigator, laboratory environment, and population in this study.

Objective To investigate the effects of arthroscopic partial meniscectomy of torn discoid lateral meniscus on patellar tracking. Methods In all, 112 patients (112 knees) who underwent arthroscopic partial meniscectomy participated in the study. All subjects were examined with standing weight-bearing magnetic resonance imaging (MRI) preoperatively and one month postoperation. Axial-plane images through the maximum width of the patella and the maximum dorsal area of the femoral condyles were superimposed and the bisect offset index used to quantify patellar translation. Differences between pre- and postoperation in the bisect offset indexes were calculated and compared by Student's paired t-test. P < 0.05 was considered statistically significant. Results Before surgery, the mean bisect offset index was 0.574 (0.437–0.692). One month postoperation, the mean bisect offset index was 0.622 (0.510–0.801). The postoperation bisect offset index increased by an average of 0.048 (−0.018 to 0.129) compared with the preoperation value; this difference is statistically significant result (t = 18.33, P < 0.01). Conclusion After arthroscopic partial meniscectomy, the patella translates more lateral to the femoral trochlear groove. These results suggest that arthroscopic partial meniscectomy may result in patellar maltracking.

Background:Matrix-assisted autologous chondrocyte transplantation (MACT) was developed to overcome the limitations of first-generation autologous chondrocyte implantation. Although short-term/midterm results are now available for a small series of patients, the literature still lacks studies on large cohorts of patients evaluated at midterm/long-term follow-up.Purpose:Not all patients can have the same benefit from this procedure. The aim of this study is to analyze a large cohort of patients treated with hyaluronan-based MACT to perform clinical profiling and to highlight the patient- and lesion-specific aspects that play a key role in determining the prognosis.Study Design:Case series; Level of evidence, 4.Methods:A total of 142 patients were treated for lesions involving the femoral condyles and trochleae; 133 knees were followed up yearly for 7 years. The average size of the defects was 2.3 ± 1.0 cm2. The origin was traumatic in 44 cases and degenerative in 57 cases, and 32 knees were affected by osteochondritis dissecans (OCD). The clinical outcome was analyzed using the International Knee Documentation Committee (IKDC), EuroQol visual analog scale, and Tegner scores. The influence of the following factors was analyzed: sex, age, body mass index, site, lesion origin, lesion size, previous or combined surgery, and symptom duration.Results:A marked improvement in all scores was found: the IKDC subjective score increased from the basal level of 39.6 ± 14.4 to 71.9 ± 19.8 ( P < .0005) at 12 months; a further improvement was observed at 24 months (77.0 ± 20.5; P < .0005). The results were stable over time up to the 7-year evaluation (77.4 ± 22.1). The failure rate was 10.7%. Better results were seen in the trochleae, and among femoral condyles, the following factors were found to influence the clinical outcome positively: traumatic and OCD origin, male sex, short symptom duration (for traumatic lesions), small lesion size (for OCD), young age, and no previous surgery.Conclusion:Treatment with MACT provides good and stable clinical results. Injury origin, sex, symptom duration, lesion size, lesion site, age, and previous surgery might determine the final outcome and can be used as a sort of clinical profiling to guide the surgeon in the choice of this procedure and in giving realistic expectations to patients requiring cartilage treatment.

Background: Autogenous osteochondral grafting has been widely performed as a treatment for focal osteochondral defects. In this procedure, it is important to match the shape of the articular surface between the donor site and recipient site to reproduce the original articular surface of the femur. Purpose: To investigate the ideal matching patterns of articular surface profiles of donor and recipient sites for autogenous osteochondral grafting of the femur using a 3-dimensional laser scanning method. Study Design: Descriptive laboratory study. Methods: The donor and recipient sites in 11 cadaveric knees were examined, and each of the sites was divided into 12 areas. In the donor sites, the contours of the articular surface of the medial and lateral femoral trochleae were determined. In the recipient sites, the contours of the articular surface of the medial and lateral femoral condyles were assessed. Vertical intervals (VIs) were then calculated as the parameter for the height of the articular surface. The VI was the height difference from the highest and lowest points in the contours of the articular surface within the area of the donor and recipient sites. Finally, assessments were made on whether the articular surface of the donor and recipient sites matched properly for cylindrical osteochondral grafts with diameters of 6, 8, and 10 mm. Results: For the donor site, the VIs of the middle area of the femoral trochlea were significantly smaller than those of the peripheral area. For the recipient site, the VIs of the anterior area of the femoral condyle were significantly smaller than those of the posterior area. Conclusion: These results indicated in aging specimens that the articular surface profile of the middle area of the donor site matched that of the anterior area of the recipient site. On the other hand, the shape of the articular surface of the peripheral area of the donor site was congruent with that of the posterior area of the recipient site. Clinical Relevance: This study will be useful for improving donor site selection during preoperative planning. The authors recommend selection of the middle area of the femoral trochlea for cartilage defects in the anterior area of the femoral condyle and of the peripheral area of the femoral trochlea for cartilage defects in the posterior area of the femoral condyle.

Objective: To investigate the effect of entangled titanium fibre balls (ETFBs) combined with nano strontium hydroxyapatite (nano-Sr-HAP) on the repair of bone defects in vivo. Materials and Methods: Twenty-four 6-month-old, specific pathogen-free, male Sprague-Dawley rats were used. Drill defects were created in bilateral femoral condyles. ETFBs combined with nano-Sr-HAP were selected randomly from 72 samples and implanted into the femoral bone defects of left legs, which served as the experimental group, while ETFBs without nano-Sr-HAP were implanted into right legs for comparison. The bone defects on both sides were X-rayed. The anteroposterior positions and histological procedures and evaluations of each sample were performed at 1, 2, 4 and 8 weeks post-surgery. Results: Histological results showed that the ETBs allowed new bone to grow within their structure. Additionally, an increase in new bone was seen on the nano-Sr-HAP side compared to the control side. The results of histomorphometric analysis confirmed that the new bone formation on the left side gradually increased with time. There was a statistical increase in new bone at 2, 4 and 8 weeks, and the differences between the two sides were statistically significant at weeks 4 and 8 (p < 0.05 for all comparisons). Conclusion: The results showed that ETFBs possess a unique 3-dimensional interconnective porous structure and have excellent biocompatibility, cell affinity and osteoconductivity, which makes them useful as scaffold materials for repairing bone defects. On the other hand, nano-Sr-HAP improved the bone defect-repairing capacity of the ETFBs, which showed osteoinductive properties.

Background: This study aims to investigate the clinical and radiological efficacy of three-dimensional acellular scaffolds (MaioRegen) in restoring osteochondral knee defects. Methods: MEDLINE, Scopus, CINAHL, Embase, and Cochrane Databases were searched for articles in which patients were treated with MaioRegen for osteochondral knee defects. Results: A total of 471 patients were included in the study (mean age 34.07 ± 5.28 years). The treatment involved 500 lesions divided as follows: 202 (40.4%) medial femoral condyles, 107 (21.4%) lateral femoral condyles, 28 (5.6%) tibial plateaus, 46 (9.2%) trochleas, 74 (14.8%) patellas, and 43 (8.6%) unspecified femoral condyles. Mean lesion size was 3.6 ± 0.85 cm2. Only four studies reported a follow-up longer than 24 months. Significant clinical improvement has been reported in almost all studies with further improvement up to 5 years after surgery. A total of 59 complications were reported of which 52 (11.1%) experienced minor complications and 7 (1.48%) major complications. A total of 16 (3.39%) failures were reported. Conclusion: This systematic review describes the current available evidence for the treatment of osteochondral knee defects with MaioRegen Osteochondral substitute reporting promising satisfactory and reliable results at mid-term follow-up. A low rate of complications and failure was reported, confirming the safety of this scaffold. Considering the low level of evidence of the study included in the review, this data does not support the superiority of the Maioregen in terms of clinical improvement at follow-up compared to conservative treatment or other cartilage techniques.

Background A scaffold for treatment of deep osteochondral defects should be stable, integrate well, and provide a surface for chondrocytes. To meet these demands, a biphasic scaffold of allogenous sterilized bone with a collagen surface was developed. Integration was tested in the sheep model. Material and methods Cartilage chips were taken from the nonweight-bearing area of the left knee of 12 sheep and cultured. After 4 wk a second procedure followed and defects of 9.4-mm diameter at the weight-bearing area of the medial femoral condyle of the right knee were created. The sterilized scaffold was inserted and the cultured autologous chondrocytes were dripped onto the surface. After 6 wk, 3 mo, and 6 mo the animals were sacrificed; the explanted femoral condyles were evaluated macroscopically and using histologic, immunohistochemical, and electronmicroscopic methods. Results After 6 wk the level of the surface was well preserved, after 3 mo parts of the scaffold were sintered but after 6 mo the surface was continuous. Full integration of the allogenous bone could be observed after 6 mo. The surface of the scaffold after 6 wk consisted of bone, but after 3 mo some chondrocytes and after 6 mo a continuous chondral layer could be detected. Conclusions The biphasic scaffold of allogenous bone and collagen proved to be stable and sufficiently integrated in the short- and midterm interval. Whether the chondrocytes on the surface had been derived from implanted chondrocytes or the scaffold with its surface was sufficiently chondroconductive must be answered in further investigations.

This translational animal model study was designed to assess function, bone ingrowth and integration, and joint pathology associated with two different synthetic, bilayered osteochondral implants over a 3-month period after implantation into the femoral condyles of dogs. SynACart-Titanium (n = 6) and SynACart-PEEK (n = 6) (Arthrex, Naples, FL, and Sites Medical, Columbia City, IN) implants were press-fit into the lateral or medial femoral condyle (alternating location) of purpose-bred adult research dogs. Dogs were humanely euthanized 3 months after surgery and the operated knees were assessed radiographically, arthroscopically, grossly, and histologically. Based on all assessments, both types of implants were well tolerated and safe with no evidence for infection, migration, or rejection. Half of the SynACart-PEEK implants showed radiographic and histologic evidence of poor incorporation with all of these being in the lateral femoral condyle. SynACart-Titanium implants were considered effective in terms of integration into bone, lack of damage to surrounding and apposing articular cartilage, and maintenance of implant integrity and architecture for the duration of the study.

More than 70 % of osteochondritis dissecans (OCD) lesions in the knee joint occur on the posterolateral surface of the medial femoral condyle, designated as the classic area. Approximately 15–20 % of OCD lesions in the knee joint occur in the inferior–central part of the lateral femoral condyle, and 1 % or less occur on the patellofemoral joint surface [1, 2]. We encountered a patient who simultaneously developed OCD in the inferior–central part of the lateral femoral condyle and in the patellofemoral joint surface.

Purpose To determine reproducibility of the femoral condyle cartilage volume (CV) in cross-sectional and longitudinal studies using various 3D imaging techniques at 1.5 T and 3 T. Materials and Methods In 21 subjects with osteoarthritis, magnetic resonance imaging (MRI) including four different sequences (sagittal 3D fat suppressed spoiled gradient-echo [SPGR] at 1.5 T, fat suppressed fast low angle shot [FLASH] at 3 T, water-excitation dual echo steady state [DESS] at 3 T, and water-excitation multiecho data image combination [MEDIC] at 3 T) were acquired at baseline and ∼1 year later. The CV measured using semiautomated segmentation software by three readers was analyzed. Results The mean of the interclass correlation coefficient between each reader from SPGR, FLASH, DESS, and MEDIC was 0.899, 0.948, 0.943, and 0.954, respectively. The mean CV (×104 mm3) measured by each reader from SPGR/FLASH/DESS/MEDIC sequences was the following in this order: 1.34/1.52/1.50/1.35, 1.21/1.43/1.40/1.27, 1.22/1.37/1.36/1.22, and 1.17/1.36/1.35/1.21 by readers 1, 2, 3 (first analysis), and 3 (second analysis), respectively. There was no statistically significant difference in CV between any readers in any sequences. The CV measured on FLASH and DESS tended to be greater than that on SPGR or MEDIC. Conclusion Inter- and intraobserver reproducibility of cartilage segmentation using semiautomated software was validated. Although there was no statistical significance, there was a tendency of under- or overestimating CV by each sequence. J. Magn. Reson. Imaging 2014;39:972–977. © 2013 Wiley Periodicals, Inc.