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4,894 results on '"Farrar P"'

351. Tissue clearing and three-dimensional imaging of intact tissues: a review on FACT protocol.

Author: Farrar, Zohreh, Afshar, Alireza, Zare, Afshin, Mussin, Nadiar M., Kaliyev, Asset A., Zhilisbayeva, Kulyash R., Mahdipour, Mahdi, and Tamadon, Amin
Published: 2024
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352. Stress testing the Centiloid: Precision and variability of PET quantification of amyloid pathology.

Author: Shekari, Mahnaz, Vállez García, David, Collij, Lyduine E., Altomare, Daniele, Heeman, Fiona, Pemberton, Hugh, Roé Vellvé, Núria, Bullich, Santiago, Buckley, Christopher, Stephens, Andrew, Farrar, Gill, Frisoni, Giovanni, Klunk, William E., Barkhof, Frederik, and Gispert, Juan Domingo
Abstract: INTRODUCTION: Assessing the potential sources of bias and variability of the Centiloid (CL) scale is fundamental for its appropriate clinical application. METHODS: We included 533 participants from AMYloid imaging to Prevent Alzheimer's Disease (AMYPAD DPMS) and Alzheimer's Disease Neuroimaging Initiative (ADNI) cohorts. Thirty‐two CL pipelines were created using different combinations of reference region (RR), RR and target types, and quantification spaces. Generalized estimating equations stratified by amyloid positivity were used to assess the impact of the quantification pipeline, radiotracer, age, brain atrophy, and harmonization status on CL. RESULTS: RR selection and RR type impact CL the most, particularly in amyloid‐negative individuals. The standard CL pipeline with the whole cerebellum as RR is robust against brain atrophy and differences in image resolution, with 95% confidence intervals below ± 3.95 CL for amyloid beta positivity cutoffs (CL < 24). DISCUSSION: The standard CL pipeline is recommended for most scenarios. Confidence intervals should be considered when operationalizing CL cutoffs in clinical and research settings. Highlights: We developed a framework for evaluating Centiloid (CL) variability to different factors.Reference region selection and delineation had the highest impact on CL values.Whole cerebellum (WCB) and whole cerebellum plus brainstem (WCB+BSTM) as reference regions yielded consistent results across tracers.The standard CL pipeline is robust against atrophy and image resolution variation.Estimated within‐ and between‐pipeline variability (95% confidence interval) in absolute CL units. [ABSTRACT FROM AUTHOR]
Published: 2024
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353. Electrophile Determines Cellular Phenotypes among XPO1-Targeting Small Molecules.

Author: Chen, Yi Fan, Shen, Yanqiu, Yan, David F., Ghazala, Maryam, Scemama de Gialluly, Marc A., Srinivasan, Ramya, Farrar, Amanda N., Friedrich, Ryan M., and Adams, Drew J.
Published: 2024
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354. Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency.

Author: Wilkie, Hazel, Das, Mrinmoy, Pelovitz, Tyler, Bainter, Wayne, Woods, Brian, Alasharee, Mohammed, Sobh, Ali, Baris, Safa, Eltan, Sevgi Bilgic, Al-Herz, Waleed, Barbouche, Mohamed-Ridha, Ben-Mustapha, Imen, Ben-Ali, Meriem, Sallam, Mohamed T.H., Awad, Amany, Lotfy, Sohilla, El Marsafy, Aisha, Ezzelarab, Moushira, Farrar, Michael, and Schmidt, Brigitta A.R.
Abstract: [Display omitted] Dedicator of cytokinesis 8 (DOCK8)-deficient patients have severe eczema, elevated IgE, and eosinophilia, features of atopic dermatitis (AD). We sought to understand the mechanisms of eczema in DOCK8 deficiency. Skin biopsy samples were characterized by histology, immunofluorescence microscopy, and gene expression. Skin barrier function was measured by transepidermal water loss. Allergic skin inflammation was elicited in mice by epicutaneous sensitization with ovalbumin (OVA) or cutaneous application of Staphylococcus aureus. Skin lesions of DOCK8-deficient patients exhibited type 2 inflammation, and the patients' skin was colonized by S aureus, as in AD. Unlike in AD, DOCK8-deficient patients had a reduced FOXP3:CD4 ratio in their skin lesions, and their skin barrier function was intrinsically intact. Dock8 −/− mice exhibited reduced numbers of cutaneous T regulatory (Treg) cells and a normal skin barrier. Dock8 −/− and mice with an inducible Dock8 deletion in Treg cells exhibited increased allergic skin inflammation after epicutaneous sensitization with OVA. DOCK8 was shown to be important for Treg cell stability at sites of allergic inflammation and for the generation, survival, and suppressive activity of inducible Treg cells. Adoptive transfer of wild-type, but not DOCK8-deficient, OVA-specific, inducible Treg cells suppressed allergic inflammation in OVA-sensitized skin of Dock8 −/− mice. These mice developed severe allergic skin inflammation and elevated serum IgE levels after topical exposure to S aureus. Both were attenuated after adoptive transfer of WT but not DOCK8-deficient Treg cells. Treg cell dysfunction increases susceptibility to allergic skin inflammation in DOCK8 deficiency and synergizes with cutaneous exposure to S aureus to drive eczema in DOCK8 deficiency. [ABSTRACT FROM AUTHOR]
Published: 2024
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355. Combined fit of spectrum and composition data as measured by the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Gorham, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlín, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present a combined fit of a simple astrophysical model of UHECR sources to both the energy spectrum and mass composition data measured by the Pierre Auger Observatory. The fit has been performed for energies above $5 \cdot 10^{18}$ eV, i.e.~the region of the all-particle spectrum above the so-called "ankle" feature. The astrophysical model we adopted consists of identical sources uniformly distributed in a comoving volume, where nuclei are accelerated through a rigidity-dependent mechanism. The fit results suggest sources characterized by relatively low maximum injection energies, hard spectra and heavy chemical composition. We also show that uncertainties about physical quantities relevant to UHECR propagation and shower development have a non-negligible impact on the fit results., Comment: Corrected typos in values of SD vertical spectrum energy bias (B.5); Added expression for SD inclined spectrum energy resolution (B.6), erroneously claimed to have been published before
Published: 2016
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356. A targeted search for point sources of EeV photons with the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Gorham, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlín, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract: Simultaneous measurements of air showers with the fluorescence and surface detectors of the Pierre Auger Observatory allow a sensitive search for EeV photon point sources. Several Galactic and extragalactic candidate objects are grouped in classes to reduce the statistical penalty of many trials from that of a blind search and are analyzed for a significant excess above the background expectation. The presented search does not find any evidence for photon emission at candidate sources, and combined $p$-values for every class are reported. Particle and energy flux upper limits are given for selected candidate sources. These limits significantly constrain predictions of EeV proton emission models from non-transient Galactic and nearby extragalactic sources, as illustrated for the particular case of the Galactic center region., Comment: Published version
Published: 2016
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357. Search for photons with energies above 10$^{18}$ eV using the hybrid detector of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Gorham, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlín, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract: A search for ultra-high energy photons with energies above 1 EeV is performed using nine years of data collected by the Pierre Auger Observatory in hybrid operation mode. An unprecedented separation power between photon and hadron primaries is achieved by combining measurements of the longitudinal air-shower development with the particle content at ground measured by the fluorescence and surface detectors, respectively. Only three photon candidates at energies 1 - 2 EeV are found, which is compatible with the expected hadron-induced background. Upper limits on the integral flux of ultra-high energy photons of 0.038, 0.010, 0.009, 0.008 and 0.007 km$^{-2}$ sr$^{-1}$ yr$^{-1}$ are derived at 95% C.L. for energy thresholds of 1, 2, 3, 5 and 10 EeV. These limits bound the fractions of photons in the all-particle integral flux below 0.14%, 0.17%, 0.42%, 0.86% and 2.9%. For the first time the photon fraction at EeV energies is constrained at the sub-percent level. The improved limits are below the flux of diffuse photons predicted by some astrophysical scenarios for cosmogenic photon production. The new results rule-out the early top-down models $-$ in which ultra-high energy cosmic rays are produced by, e.g., the decay of super-massive particles $-$ and challenge the most recent super-heavy dark matter models., Comment: Corrected version after erratum published in JCAP
Published: 2016
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358. Multi-resolution anisotropy studies of ultrahigh-energy cosmic rays detected at the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, A. L., Müller, G., Muller, M. A., Müller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlín, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report a multi-resolution search for anisotropies in the arrival directions of cosmic rays detected at the Pierre Auger Observatory with local zenith angles up to $80^\circ$ and energies in excess of 4 EeV ($4 \times 10^{18}$ eV). This search is conducted by measuring the angular power spectrum and performing a needlet wavelet analysis in two independent energy ranges. Both analyses are complementary since the angular power spectrum achieves a better performance in identifying large-scale patterns while the needlet wavelet analysis, considering the parameters used in this work, presents a higher efficiency in detecting smaller-scale anisotropies, potentially providing directional information on any observed anisotropies. No deviation from isotropy is observed on any angular scale in the energy range between 4 and 8 EeV. Above 8 EeV, an indication for a dipole moment is captured; while no other deviation from isotropy is observed for moments beyond the dipole one. The corresponding $p$-values obtained after accounting for searches blindly performed at several angular scales, are $1.3 \times 10^{-5}$ in the case of the angular power spectrum, and $2.5 \times 10^{-3}$ in the case of the needlet analysis. While these results are consistent with previous reports making use of the same data set, they provide extensions of the previous works through the thorough scans of the angular scales., Comment: Published version. Added journal reference and DOI. Added Report Number
Published: 2016
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359. Testing Hadronic Interactions at Ultrahigh Energies with Air Showers Measured by the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allen, J., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., del Peral, L., Deligny, O., Dhital, N., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gallo, F., García, B., Garcia-Pinto, D., Gate, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Latronico, L., Lauscher, M., Lautridou, P., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Mello, V. B. B., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. A., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pepe, I. M., Pereira, L. A. S., Perrone, L., Petermann, E., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento-Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stapleton, J., Stasielak, J., Strafella, F., Stutz, A., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valbuena-Delgado, A., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yapici, T., Yelos, D., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract: Ultrahigh energy cosmic ray air showers probe particle physics at energies beyond the reach of accelerators. Here we introduce a new method to test hadronic interaction models without relying on the absolute energy calibration, and apply it to events with primary energy 6-16 EeV (E_CM = 110-170 TeV), whose longitudinal development and lateral distribution were simultaneously measured by the Pierre Auger Observatory. The average hadronic shower is 1.33 +- 0.16 (1.61 +- 0.21) times larger than predicted using the leading LHC-tuned models EPOS-LHC (QGSJetII-04), with a corresponding excess of muons., Comment: Published version. Added journal reference and DOI. Added Report Number
Published: 2016
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360. Constructing oxide interfaces and heterostructures by atomic layer-by-layer laser molecular beam epitaxy

Author: Lei, Qingyu, Golalikhani, Maryam, Davidson, Bruce A., Liu, Guozhen, Schlom, D. G., Qiao, Qiao, Zhu, Yimei, Chandrasena, Ravini U., Yang, Weibing, Gray, Alexander X., Arenholz, Elke, Farrar, Andrew K., Tenne, Dmitri A., Hu, Minhui, Guo, Jiandong, Singh, Rakesh K., and Xi, X. X.
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: Advancements in nanoscale engineering of oxide interfaces and heterostructures have led to discoveries of emergent phenomena and new artificial materials. Combining the strengths of reactive molecular-beam epitaxy and pulsed-laser deposition, we show here, with examples of Sr1+xTi1-xO3+delta, Ruddlesden-Popper phase Lan+1NinO3n+1 (n = 4), and LaAl1+yO3(1+0.5y)/SrTiO3 interfaces, that atomic layer-by-layer laser molecular-beam epitaxy (ALL-Laser MBE) significantly advances the state of the art in constructing oxide materials with atomic layer precision and control over stoichiometry. With ALL-Laser MBE we have produced conducting LaAlO3/SrTiO3 interfaces at high oxygen pressures that show no evidence of oxygen vacancies, a capability not accessible by existing techniques. The carrier density of the interfacial two-dimensional electron gas thus obtained agrees quantitatively with the electronic reconstruction mechanism.
Published: 2016

361. Statins Modulate Microenvironmental Cues Driving Macrophage Polarization in Simulated Periodontal Inflammation

Author: Waleed Alkakhan, Nico Farrar, Vanessa Sikora, Pinar Emecen-Huja, Sarandeep S. Huja, Özlem Yilmaz, and Subramanya N. Pandruvada
Subjects: periodontal disease, host immune response, macrophage polarization, statins, adjunctive therapy, Cytology, QH573-671
Abstract: Periodontal disease (PD) is a chronic inflammatory disorder characterized by the destruction of connective tissue, tooth loss, and systemic infections. Clinically, treatment of PD includes control of the etiologic factors via several modalities: initial therapy including scaling and root planing (SRP), corrective phase of surgical treatment, both with and without adjunct antimicrobial/pharmacological agents, followed by a maintenance/supportive periodontal therapy phase. Each treatment phase aims to control oral biofilm by addressing risk factors and etiology. Monotherapy of systemic antibiotics is insufficient compared to their use as an adjunct to SRP. The critical issue of systemic antimicrobial usage includes adverse patient outcomes and increased bacterial resistance. Therefore, alternative adjuncts to periodontal therapy have been sought. Statins are widely prescribed for the treatment of hypercholesterolemia and cardiovascular disease. Statins have demonstrated anti-inflammatory properties and immunomodulatory effects, and a few retrospective studies showed that statin patients exhibit fewer signs of periodontal inflammation than subjects without the medication. Despite the available clinical studies on the local administration of statins for PD, no studies have reported the macrophage polarization response. We have developed a gingival fibroblast–macrophage co-culture model to track macrophage response when exposed to a battery of microenvironmental cues mimicking macrophage polarization/depolarization observed in vivo. Using our model, we demonstrate that simvastatin suppresses macrophage inflammatory response and upregulates tissue homeostasis and M2 macrophage markers. Our findings support the usage of statins to mitigate periodontal inflammation as a valid strategy.
Published: 2023
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362. The Role of FAS Receptor Methylation in Osteosarcoma Metastasis

Author: Jiayi M. Sun, Wing-Yuk Chow, Gufeng Xu, M. John Hicks, Manjula Nakka, Jianhe Shen, Patrick Kwok Shing Ng, Aaron M. Taylor, Alexander Yu, Jason E. Farrar, Donald A. Barkauskas, Richard Gorlick, Jaime M. Guidry Auvil, Daniela Gerhard, Paul Meltzer, Rudy Guerra, Tsz-Kwong Man, Ching C. Lau, and on behalf of the TARGET Osteosarcoma Consortium
Subjects: osteosarcoma, FAS receptor, DNA methylation, 5-azacytidine, prognosis, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract: Osteosarcoma is the most frequent primary malignant bone tumor with an annual incidence of about 400 cases in the United States. Osteosarcoma primarily metastasizes to the lungs, where FAS ligand (FASL) is constitutively expressed. The interaction of FASL and its cell surface receptor, FAS, triggers apoptosis in normal cells; however, this function is altered in cancer cells. DNA methylation has previously been explored as a mechanism for altering FAS expression, but no variability was identified in the CpG island (CGI) overlapping the promoter. Analysis of an expanded region, including CGI shores and shelves, revealed high variability in the methylation of certain CpG sites that correlated significantly with FAS mRNA expression in a negative manner. Bisulfite sequencing revealed additional CpG sites, which were highly methylated in the metastatic LM7 cell line but unmethylated in its parental non-metastatic SaOS-2 cell line. Treatment with the demethylating agent, 5-azacytidine, resulted in a loss of methylation in CpG sites located within the FAS promoter and restored FAS protein expression in LM7 cells, resulting in reduced migration. Orthotopic implantation of 5-azacytidine treated LM7 cells into severe combined immunodeficient mice led to decreased lung metastases. These results suggest that DNA methylation of CGI shore sites may regulate FAS expression and constitute a potential target for osteosarcoma therapy, utilizing demethylating agents currently approved for the treatment of other cancers.
Published: 2023
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363. The Carrier Frequency of Two SMN1 Genes in Parents of Symptomatic Children with SMA and the Significance of SMN1 Exon 8 in Carriers

Author: Joanne E Davidson, Jacqueline S Russell, Noelia Nunez Martinez, David R Mowat, Kristi J Jones, Edwin P Kirk, Didu Kariyawasam, Michelle Farrar, and Arlene D’Silva
Subjects: spinal muscular atrophy, carrier frequency, silent carrier, reproductive carrier screening, Genetics, QH426-470
Abstract: Background: Current carrier screening methods do not identify a proportion of carriers that may have children affected by spinal muscular atrophy (SMA). Additional genetic data is essential to inform accurate risk assessment and genetic counselling of SMA carriers. This study aims to quantify the various genotypes among parents of children with SMA. Method: A retrospective cohort study was undertaken at Sydney Children’s Hospital Network, the major SMA referral centre for New South Wales, Australia. Participants included children with genetically confirmed SMA born between 2005 and 2021. Data was collected on parent genotype inclusive of copy number of SMN1 exons 7 and 8. The number of SMN2 exon 7 copies were recorded for the affected children. Descriptive statistics were used to determine the proportion of carriers of 2+0 genotype classified as silent carriers. Chi-square test was used to correlate the association between parents with a heterozygous SMN1 exon 7 deletion and two copies of exon 8 and ≥3 SMN2 copy number in the proband. Results: SMA carrier testing was performed in 118/154 (76.6%) parents, incorporating 59 probands with homozygous SMN1 deletions and one proband with compound heterozygote pathogenic variants. Among parents with a child with SMA, 7.6% had two copies of SMN1 exon 7. When only probands with a homozygous SMN1 exon 7 deletion were included, 6.9% of parents had two copies of SMN1 exon 7. An association was observed between heterozygous deletion of SMN1 exon 7 with two copies of exon 8 in a parent and ≥3 SMN2 copy number in the affected proband (p = 0.07). Conclusions: This study confirmed a small but substantial proportion of silent carriers not identified by conventional screening within an Australian context. Accordingly, the effectiveness of carrier screening for SMA is linked with genetic counselling to enable health literacy regarding high and low risk results and is complemented by new-born screening and maintaining clinical awareness for SMA. Gene conversion events may underpin the associations between parent carrier status and proband SMN2 copy number.
Published: 2023
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364. Management of significant secondary genetic findings in an ophthalmic genetics clinic

Author: Zhu, Julia, Stephenson, Kirk A J, Farrar, G. Jane, Turner, Jacqueline, O’Byrne, James J., and Keegan, David
Published: 2022
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365. Correction to: Oncolytic HSV1 targets different growth phases of breast cancer leptomeningeal metastases

Author: Kuruppu, Darshini, Bhere, Deepak, Farrar, Christian T., Shah, Khalid, Brownell, Anna-Liisa, Mahmood, Umar, and Tanabe, Kenneth K.
Published: 2023
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366. Liminal Spaces Constructed by Primary Schools in Predominantly White Working-Class Areas in England

Author: Puttick, Steven, Hill, Yvonne, Beckley, Pat, Farrar, Elizabeth, Luby, Antony, and Hounslow-Eyre, Adam
Abstract: Despite successive policy interventions, students' socio-economic status continues to strongly predict educational outcomes. Many schools aspire to 'close' this 'gap'. This paper presents an ethnographic study of a group of Primary schools in predominantly white working-class areas in the Midlands of England. Generating ethnographic data through time-recurrent, multi-sited fieldwork including observation, informal conversations, semi-structured interviews, photography and documentary analysis, findings were constructed through critical dialogue between the group of six researchers. A concept of liminal spaces is used to analyse the schools' work in seeking to move individuals, families, and communities beyond that which they previously knew, foregrounding norms, practices, and discourses constructed on the 'inside', and highlighting aspects in tension with the imagined 'outside'. These schools' conceptualisations of poverty are shown to be complex and multifaceted, and suggestions are made to employ liminality for articulating and critically exploring the spaces and transformations that schools seek to construct.
Published: 2020
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367. Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK

Author: Pouwels, Koen B., Pritchard, Emma, Matthews, Philippa C., Stoesser, Nicole, Eyre, David W., Vihta, Karina-Doris, House, Thomas, Hay, Jodie, Bell, John I., Newton, John N., Farrar, Jeremy, Crook, Derrick, Cook, Duncan, Rourke, Emma, Studley, Ruth, Peto, Tim E. A., Diamond, Ian, and Walker, A. Sarah
Published: 2021
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368. Effects of Biochar on Pulse C and N Cycling After a Short-term Drought: a Laboratory Study

Author: Citerne, Nadine, Wallace, Helen M., Lewis, Tom, Reverchon, Frédérique, Omidvar, Negar, Hu, Hang-Wei, Shi, Xiu-Zhen, Zhou, Xuhui, Zhou, Guiyao, Farrar, Michael, Rashti, Mehran Rezaei, and Bai, Shahla Hosseini
Published: 2021
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369. Complement in ischaemia–reperfusion injury and transplantation

Author: Howard, Mark C., Nauser, Christopher L., Farrar, Conrad A., and Sacks, Steven H.
Published: 2021
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370. Speaking Up and Speaking Out: Gender Diversity in the Scientific Programme of the Royal Australasian College of Surgeons Annual Scientific Congress

Author: Lai, Christine S., Farrar, Jessica, Stanzah, Fellicia, Crammond, Bradley, Wong, Sandra L., and Lee, James C.
Published: 2021
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371. Rapid allopolyploid radiation of moonwort ferns (Botrychium; Ophioglossaceae) revealed by PacBio sequencing of homologous and homeologous nuclear regions

Author: Dauphin, Benjamin, Grant, Jason R, Farrar, Donald R, and Rothfels, Carl J
Subjects: Biological Sciences, Evolutionary Biology, Genetics, Bayes Theorem, Cell Nucleus, Computational Biology, Cryptochromes, DNA, Plant, Ferns, Phylogeny, Polyploidy, Sequence Analysis, DNA, Low-copy markers, PacBio, Polyploid network, PURC, Reticulate evolution, Zoology, Evolutionary biology
Abstract: Polyploidy is a major speciation process in vascular plants, and is postulated to be particularly important in shaping the diversity of extant ferns. However, limitations in the availability of bi-parental markers for ferns have greatly limited phylogenetic investigation of polyploidy in this group. With a large number of allopolyploid species, the genus Botrychium is a classic example in ferns where recurrent polyploidy is postulated to have driven frequent speciation events. Here, we use PacBio sequencing and the PURC bioinformatics pipeline to capture all homeologous or allelic copies of four long (∼1 kb) low-copy nuclear regions from a sample of 45 specimens (25 diploids and 20 polyploids) representing 37 Botrychium taxa, and three outgroups. This sample includes most currently recognized Botrychium species in Europe and North America, and the majority of our specimens were genotyped with co-dominant nuclear allozymes to ensure species identification. We analyzed the sequence data using maximum likelihood (ML) and Bayesian inference (BI) concatenated-data ("gene tree") approaches to explore the relationships among Botrychium species. Finally, we estimated divergence times among Botrychium lineages and inferred the multi-labeled polyploid species tree showing the origins of the polyploid taxa, and their relationships to each other and to their diploid progenitors. We found strong support for the monophyly of the major lineages within Botrychium and identified most of the parental donors of the polyploids; these results largely corroborate earlier morphological and allozyme-based investigations. Each polyploid had at least two distinct homeologs, indicating that all sampled polyploids are likely allopolyploids (rather than autopolyploids). Our divergence-time analyses revealed that these allopolyploid lineages originated recently-within the last two million years-and thus that the genus has undergone a recent radiation, correlated with multiple independent allopolyploidizations across the phylogeny. Also, we found strong parental biases in the formation of allopolyploids, with individual diploid species participating multiple times as either the maternal or paternal donor (but not both). Finally, we discuss the role of polyploidy in the evolutionary history of Botrychium and the interspecific reproductive barriers possibly involved in these parental biases.
Published: 2018

372. The energy spectrum of cosmic rays beyond the turn-down around $$\varvec{10^{17}}$$ 10 17 eV as measured with the surface detector of the Pierre Auger Observatory

Author: P. Abreu, M. Aglietta, J. M. Albury, I. Allekotte, A. Almela, J. Alvarez-Muñiz, R. Alves Batista, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, J. C. Arteaga Velázquez, H. Asorey, P. Assis, G. Avila, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R. J. Barreira Luz, K. H. Becker, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, P. Billoir, V. Binet, K. Bismark, T. Bister, J. Biteau, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, A. M. Botti, J. Brack, T. Bretz, P. G. Brichetto Orchera, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, M. Büsken, K. S. Caballero-Mora, L. Caccianiga, F. Canfora, I. Caracas, J. M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, D. Correia dos Santos, C. E. Covault, S. Dasso, K. Daumiller, B. R. Dawson, J. A. Day, R. M. de Almeida, J. de Jesús, S. J. de Jong, G. De Mauro, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, F. de Palma, V. de Souza, E. De Vito, M. del Río, O. Deligny, A. Di Matteo, C. Dobrigkeit, J. C. D’Olivo, L. M. Domingues Mendes, R. C. dos Anjos, D. dos Santos, M. T. Dova, J. Ebr, R. Engel, I. Epicoco, M. Erdmann, C. O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, T. Fitoussi, T. Fodran, M. M. Freire, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, A. L. Garcia Vegas, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, J. Glombitza, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, J. M. González, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, P. Hamal, M. R. Hampel, P. Hansen, D. Harari, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, G. C. Hill, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, A. Insolia, P. G. Isar, P. Janecek, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, N. Karastathis, B. Keilhauer, J. Kemp, A. Khakurdikar, V. V. Kizakke Covilakam, H. O. Klages, M. Kleifges, J. Kleinfeller, M. Köpke, N. Kunka, B. L. Lago, R. G. Lang, N. Langner, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, L. Lu, Q. Luce, J. P. Lundquist, A. Machado Payeras, G. Mancarella, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, S. Marafico, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, S. Martinelli, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, P. O. Mazur, G. Medina-Tanco, D. Melo, A. Menshikov, K.-D. Merenda, S. Michal, M. I. Micheletti, L. Miramonti, D. Mockler, S. Mollerach, F. Montanet, C. Morello, M. Mostafá, A. L. Müller, M. A. Muller, K. Mulrey, R. Mussa, M. Muzio, W. M. Namasaka, A. Nasr-Esfahani, L. Nellen, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A. Nucita, L. A. Núñez, M. Palatka, J. Pallotta, P. Papenbreer, G. Parente, A. Parra, J. Pawlowsky, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, E. E. Pereira Martins, J. Perez Armand, C. Pérez Bertolli, M. Perlin, L. Perrone, S. Petrera, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, B. Pont, M. Pothast, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, P. Savina, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F. G. Schröder, S. Schröder, J. Schulte, A. Schulz, S. J. Sciutto, M. Scornavacche, A. Segreto, S. Sehgal, R. C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, P. Sommers, J. F. Soriano, J. Souchard, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, A. Streich, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, Z. Szadkowski, A. Tapia, C. Taricco, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, Z. Torrès, A. Travaini, P. Travnicek, C. Trimarelli, M. Tueros, R. Ulrich, M. Unger, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, J. Vink, S. Vorobiov, H. Wahlberg, C. Watanabe, A. A. Watson, M. Weber, A. Weindl, L. Wiencke, H. Wilczyński, M. Wirtz, D. Wittkowski, B. Wundheiler, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, and Pierre Auger Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract We present a measurement of the cosmic-ray spectrum above 100 PeV using the part of the surface detector of the Pierre Auger Observatory that has a spacing of 750 m. An inflection of the spectrum is observed, confirming the presence of the so-called second-knee feature. The spectrum is then combined with that of the 1500 m array to produce a single measurement of the flux, linking this spectral feature with the three additional breaks at the highest energies. The combined spectrum, with an energy scale set calorimetrically via fluorescence telescopes and using a single detector type, results in the most statistically and systematically precise measurement of spectral breaks yet obtained. These measurements are critical for furthering our understanding of the highest energy cosmic rays.
Published: 2021
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373. Whole genome sequencing and in vitro splice assays reveal genetic causes for inherited retinal diseases

Author: Zeinab Fadaie, Laura Whelan, Tamar Ben-Yosef, Adrian Dockery, Zelia Corradi, Christian Gilissen, Lonneke Haer-Wigman, Jordi Corominas, Galuh D. N. Astuti, Laura de Rooij, L. Ingeborgh van den Born, Caroline C. W. Klaver, Carel B. Hoyng, Niamh Wynne, Emma S. Duignan, Paul F. Kenna, Frans P. M. Cremers, G. Jane Farrar, and Susanne Roosing
Subjects: Medicine, Genetics, QH426-470
Abstract: Abstract Inherited retinal diseases (IRDs) are a major cause of visual impairment. These clinically heterogeneous disorders are caused by pathogenic variants in more than 270 genes. As 30–40% of cases remain genetically unexplained following conventional genetic testing, we aimed to obtain a genetic diagnosis in an IRD cohort in which the genetic cause was not found using whole-exome sequencing or targeted capture sequencing. We performed whole-genome sequencing (WGS) to identify causative variants in 100 unresolved cases. After initial prioritization, we performed an in-depth interrogation of all noncoding and structural variants in genes when one candidate variant was detected. In addition, functional analysis of putative splice-altering variants was performed using in vitro splice assays. We identified the genetic cause of the disease in 24 patients. Causative coding variants were observed in genes such as ATXN7, CEP78, EYS, FAM161A, and HGSNAT. Gene disrupting structural variants were also detected in ATXN7, PRPF31, and RPGRIP1. In 14 monoallelic cases, we prioritized candidate noncanonical splice sites or deep-intronic variants that were predicted to disrupt the splicing process based on in silico analyses. Of these, seven cases were resolved as they carried pathogenic splice defects. WGS is a powerful tool to identify causative variants residing outside coding regions or heterozygous structural variants. This approach was most efficient in cases with a distinct clinical diagnosis. In addition, in vitro splice assays provide important evidence of the pathogenicity of rare variants.
Published: 2021
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374. Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation

Author: Robin D. Lee, Sarah A. Munro, Todd P. Knutson, Rebecca S. LaRue, Lynn M. Heltemes-Harris, and Michael A. Farrar
Subjects: Science
Abstract: The characterisation of B cell progenitors could benefit from single cell RNA analysis. Here the authors show distinct transcriptional profiles of B cell progenitors which are dependent upon pre-BCR and these profiles can be related to B cell transformation in lymphoblastic leukaemia.
Published: 2021
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375. Anti-spike antibody response to natural SARS-CoV-2 infection in the general population

Author: Jia Wei, Philippa C. Matthews, Nicole Stoesser, Thomas Maddox, Luke Lorenzi, Ruth Studley, John I. Bell, John N. Newton, Jeremy Farrar, Ian Diamond, Emma Rourke, Alison Howarth, Brian D. Marsden, Sarah Hoosdally, E. Yvonne Jones, David I. Stuart, Derrick W. Crook, Tim E. A. Peto, Koen B. Pouwels, A. Sarah Walker, David W. Eyre, and the COVID-19 Infection Survey team
Subjects: Science
Abstract: Most people who are infected with SARS-CoV-2 seroconvert within a few weeks, but the determinants and duration of the antibody response are not known. Here, the authors characterise these features of the immune response using data from a large representative community sample of the UK population.
Published: 2021
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376. SHARIAH-BASED SUFISM IN THE MODERN ERA: A LOOK AT THE WORK OF SHAYKH ABDULLAH BIN BAYYAH

Author: Salim Farrar
Subjects: Sufism, Practical, Shariah, Contemporary Society, 'Abdullah bin Bayyah, Islamic law, KBP1-4860, Law
Abstract: This article examines the legal (sharʿī) validity and practical relevance of Sufism in the modern era through exploring the life and works of the contemporary Mālikī scholar, Shaykh ʿAbdullāh Bin Bayyah. Famous for his works in Mālikī Fiqh, Uṣūl al-Fiqh and global work with Muslim minorities (especially Fiqh al-ʿAqalliyāt), Shaykh bin Bayyah is less well-known for his Sufism. And yet, the life and works of the religious figurehead of a network that extends from West and North Africa, and the Gulf countries, to the United Kingdom and the west coast of the United States of America, provide an illuminating window on some forms of contemporary Sufism. Drawing upon official biographies, secondary literature, a personal interview, and a key, as yet unpublished, text, Al-Mākhidh ʿalā al-Taṣawwuf (The Criticisms of Sufism), the author argues Bin Bayyah has a distinctive (though not necessarily unique) practical approach to Sufism that is most relevant to our times. Not only does it help provide a balanced, tolerant, and learned antidote to religious extremism, which is firmly rooted in the Syariah, his practical Sufism also lays the foundations of a path towards civic contribution of Ṣūfī communities in fields as diverse as education, prison reform and peace-making.
Published: 2022
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377. Providing height to pullets does not influence hippocampal dendritic morphology or brain-derived neurotrophic factor at the end of the rearing period

Author: Allison N. Pullin, Victoria S. Farrar, Jason W. Loxterkamp, Claire T. Jones, Rebecca M. Calisi, Kristina Horback, Pamela J. Lein, and Maja M. Makagon
Subjects: brain-derived neurotrophic factor, chicken, Golgi stain, hippocampus, rearing environment, Animal culture, SF1-1100
Abstract: ABSTRACT: Pullets reared with diverse behavioral experiences are faster to learn spatial cognition tasks and acclimate more successfully to laying environments with elevated structures. However, the neural underpinnings of the improved spatial abilities are unclear. The objective of this study was to determine whether providing structural height in the rearing environment affected the development of the hippocampus and whether hippocampal neural metrics correlated with individual behavior on spatial cognition tasks. Female Dekalb White pullets were reared in a floor pen (FL), single-tiered aviary (ST), or two-tiered aviary (TT; 5 pens/treatment). Pullets completed floor-based Y-maze and elevated visual cliff tasks to evaluate depth perception at 15 and 16 wk, respectively. At 16 wk, brains were removed for Golgi-Cox staining (n = 12 for FL, 13 for ST, 13 total pullets for TT; 2 to 3 pullets/pen) and qPCR to measure gene expression of brain-derived neurotrophic factor (BDNF; n = 10 for FL, 11 for ST, and 9 pullets for TT). Rearing environment did not affect various morphometric outcomes of dendritic arborization, including Sholl profiles; mean dendritic length; sum dendritic length; number of dendrites, terminal tips, or nodes; soma size; or BDNF mRNA expression (P > 0.05). Hippocampal subregion did affect dendritic morphology, with multipolar neurons from the ventral subregion differing in several characteristics from multipolar neurons in the dorsomedial or dorsolateral subregions (P < 0.05). Neural metrics did not correlate with individual differences in behavior during the spatial cognition tasks. Overall, providing height during rearing did not affect dendritic morphology or BDNF at 16 wk of age, but other metrics in the hippocampus or other brain regions warrant further investigation. Additionally, other structural or social components or the role of animal personality are areas of future interest for how rearing environments influence pullet behavior.
Published: 2022
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378. Treatment patterns and unmet needs in adults with classic congenital adrenal hyperplasia: A modified Delphi consensus study

Author: Richard J. Auchus, Carine Courtillot, Adrian Dobs, Diala El-Maouche, Henrik Falhammar, Andre Lacroix, Mallory Farrar, Conor O’Donoghue, Milena Anatchkova, Katelyn Cutts, Natalie Taylor, Chuck Yonan, Mark Lamotte, and Philippe Touraine
Subjects: classic CAH, classic congenital adrenal hyperplasia, glucocorticoid management, treatment complication, unmet needs, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: BackgroundClassic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is a rare autosomal recessive condition characterized by cortisol deficiency and excess androgen production. The current standard of care is glucocorticoid (GC) therapy, and sometimes mineralocorticoids, to replace endogenous cortisol deficiency; however, supraphysiologic GC doses are usually needed to reduce excess androgen production. Monitoring/titrating GC treatment remains a major challenge, and there is no agreement on assessment of treatment adequacy. This study surveyed expert opinions on current treatment practices and unmet needs in adults with classic CAH.MethodsA modified two-round Delphi process with adult endocrinologists was conducted via online questionnaire. Survey questions were organized into three categories: practice characteristics/CAH experience, GC management, and unmet needs/complications. Anonymized aggregate data from Round 1 were provided as feedback for Round 2. Responses from both rounds were analyzed using descriptive statistics. Consensus was defined a priori as: full consensus (100%, n=9/9); near consensus (78% to
Published: 2022
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379. Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021

Author: Daniel S. Farrar, Olivier Drouin, Charlotte Moore Hepburn, Krista Baerg, Kevin Chan, Claude Cyr, Elizabeth J. Donner, Joanne E. Embree, Catherine Farrell, Sarah Forgie, Ryan Giroux, Kristopher T. Kang, Melanie King, Melanie Laffin Thibodeau, Julia Orkin, Naïm Ouldali, Jesse Papenburg, Catherine M. Pound, Victoria E. Price, Jean-Philippe Proulx-Gauthier, Rupeena Purewal, Christina Ricci, Manish Sadarangani, Marina I. Salvadori, Roseline Thibeault, Karina A. Top, Isabelle Viel-Thériault, Fatima Kakkar, and Shaun K. Morris
Subjects: COVID-19, SARS-CoV-2, Hospitalization, Risk factors, Children, Surveillance, Public aspects of medicine, RA1-1270
Abstract: Summary: Background: Children living with chronic comorbid conditions are at increased risk for severe COVID-19, though there is limited evidence regarding the risks associated with specific conditions and which children may benefit from targeted COVID-19 therapies. The objective of this study was to identify factors associated with severe disease among hospitalized children with COVID-19 in Canada. Methods: We conducted a national prospective study on hospitalized children with microbiologically confirmed SARS-CoV-2 infection via the Canadian Paediatric Surveillance Program (CPSP) from April 2020–May 2021. Cases were reported voluntarily by a network of >2800 paediatricians. Hospitalizations were classified as COVID-19-related, incidental infection, or infection control/social admissions. Severe disease (among COVID-19-related hospitalizations only) was defined as disease requiring intensive care, ventilatory or hemodynamic support, select organ system complications, or death. Risk factors for severe disease were identified using multivariable Poisson regression, adjusting for age, sex, concomitant infections, and timing of hospitalization. Findings: We identified 544 children hospitalized with SARS-CoV-2 infection, including 60·7% with COVID-19-related disease and 39·3% with incidental infection or infection control/social admissions. Among COVID-19-related hospitalizations (n=330), the median age was 1·9 years (IQR 0·1–13·3) and 43·0% had chronic comorbid conditions. Severe disease occurred in 29·7% of COVID-19-related hospitalizations (n=98/330 including 60 admitted to intensive care), most frequently among children aged 2-4 years (48·7%) and 12-17 years (41·3%). Comorbid conditions associated with severe disease included pre-existing technology dependence requirements (adjusted risk ratio [aRR] 2·01, 95% confidence interval [CI] 1·37-2·95), body mass index Z-scores ≥3 (aRR 1·90, 95% CI 1·10-3·28), neurologic conditions (e.g. epilepsy and select chromosomal/genetic conditions) (aRR 1·84, 95% CI 1·32-2·57), and pulmonary conditions (e.g. bronchopulmonary dysplasia and uncontrolled asthma) (aRR 1·63, 95% CI 1·12-2·39). Interpretation: While severe outcomes were detected at all ages and among patients with and without comorbidities, neurologic and pulmonary conditions as well as technology dependence were associated with increased risk of severe COVID-19. These findings may help guide vaccination programs and prioritize targeted COVID-19 therapies for children. Funding: Financial support for the CPSP was received from the Public Health Agency of Canada.
Published: 2022
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380. Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome

Author: Bin Ni, Shanshan Chen, Kathleen A. Ryan, Michael L. Maitland, Jared S. Farrar, Martin Witzenrath, Birgitt Gubier, Cindy Serdjebi, Karine Bertotti, Rui Wang, Fadi N. Salloum, Luigi Marino, Braxton D. Mitchell, and Francesco S. Celi
Subjects: ANGPT2, Ucp1, Brown fat, Estrogen, Obesity, Female, Internal medicine, RC31-1245
Abstract: Thermogenic fat differentiation and function can be promoted through multiple pathways, resulting in a common cell phenotype characterized by the expression of Uncoupling Protein-1 and the ability to dissipate energy, but local and systemic stimuli are necessary to promote adequate thermogenic fat vascularization, which is a precondition for the transport of substrate and the dissipation of heat. Angiopoietin-2 is an important driver of vascularization, and its transcription is in part promoted by estrogen signaling. In this study we demonstrate that adipose tissue-specific knock out of Angiopoietin-2 causes a female-specific reduced thermogenic fat differentiation and function, resulting in obesity and impaired glucose tolerance with end-organ features consistent with metabolic syndrome. In humans, angiopoietin-2 levels are higher in females than in males, and are inversely correlated with adiposity and age more strongly in pre-menopause when compared to post-menopause. Collectively, these data indicate a novel and important role for estrogen-mediated Angiopoietin-2 adipose tissue production in the protection against calorie overload in females, and potentially in the development of postmenopausal weight gain.
Published: 2022
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381. Immune characterization of suicidal behavior in female adolescents

Author: Cherise R. Chin Fatt, J. David Farrar, Manish K. Jha, Abu Minhajuddin, Taryn Mayes, Jane A. Foster, and Madhukar H. Trivedi
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Background: To address the need to identify potential markers of suicide behavior for adolescents (ages 12–18 years), mass cytometry was used to explore the cellular mechanisms that may underpin immune dysregulation in adolescents with recent suicidal behavior. Methods: Peripheral blood mononuclear cell (PBMC) samples from 10 female adolescents with a recent suicide attempt and 4 healthy female adolescents were used. A panel of 30 antibodies was analyzed using mass cytometry. We used two complementary approaches to 1) identify the cell types that significantly differed between the two groups, and 2) explore differences in the expression profile of markers on the surface of these cells. Mass cytometry data were investigated using (Center for Disease Control, 2021) Opt-SNE for dimension reduced (Curtin and Heron, 2019), FlowSOM for clustering, and (Bridge et al., 2006) EgdeR and SAM for statistical analyses. Results: Opt-SNE (a data driven clustering analysis) identified 15 clusters of distinct cell types. From these 15 clusters, cluster 5 (classical monocytes) had statistically lower abundance in suicidal adolescents as compared to healthy controls, whereas cluster 7 (gamma-delta T cells) had statistically higher abundance in suicidal adolescents compared to healthy control. Furthermore, across the 15 cell types, chemokine receptors, CXCR3 (cluster 5) and CXCR5 (clusters 4, 5, 7, and 9), had an elevated expression profile in those with a recent suicide attempt versus healthy controls. Conclusion: This report demonstrates the utility of high dimensional cell phenotyping in psychiatric disorders and provides preliminary evidence for distinct immune dysfunctions in adolescents with recent suicide attempts as compared to healthy controls.
Published: 2022
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382. Barriers and Strategies for Recruitment of Racial and Ethnic Minorities: Perspectives from Neurological Clinical Research Coordinators.

Author: Haley, Sean, Southwick, Lauren, Parikh, Nina, Rivera, Jazmin, Farrar-Edwards, Dorothy, and Boden-Albala, Bernadette
Subjects: Barriers, Clinical research coordinators, Clinical trials, Secondary 92C50, Strategies MSC Primary 91C99, Underrepresented populations, Clinical Trials as Topic, Ethnicity, Female, Focus Groups, Humans, Male, Minority Groups, Nervous System Diseases, Patient Selection, Racial Groups, Research Personnel
Abstract: INTRODUCTION: Randomized controlled trials (RCTs) are the gold standard within evidence-based research. Low participant accrual rates, especially of underrepresented groups (e.g., racial-ethnic minorities), may jeopardize clinical studies viability and strength of findings. Research has begun to unweave clinical trial mechanics, including the roles of clinical research coordinators, to improve trial participation rates. METHODS: Two semi-structured focus groups were conducted with a purposive sample of 29 clinical research coordinators (CRCs) at consecutive international stroke conferences in 2013 and 2014 to gain in-depth understanding of coordinator-level barriers to racial-ethnic minority recruitment and retention into neurological trials. Coded transcripts were used to create themes to define concepts, identify associations, summarize findings, and posit explanations. RESULTS: Barriers related to translation, literacy, family composition, and severity of medical diagnosis were identified. Potential strategies included a focus on developing personal relationships with patients, community and patient education, centralized clinical trial administrative systems, and competency focused training and education for CRCs. CONCLUSION: Patient level barriers to clinical trial recruitment are well documented. Less is known about barriers facing CRCs. Further identification of how and when barriers manifest and the effectiveness of strategies to improve CRCs recruitment efforts is warranted.
Published: 2017

383. OMERACT Endorsement of Patient-reported Outcome Instruments in Antineutrophil Cytoplasmic Antibody-associated Vasculitis.

Author: Robson, Joanna, Tomasson, Gunnar, Milman, Nataliya, Ashdown, Sue, Boonen, Annelies, Casey, George, Cronholm, Peter, Cuthbertson, David, Dawson, Jill, Direskeneli, Haner, Easley, Ebony, Kermani, Tanaz, Farrar, John, Gebhart, Don, Lanier, Georgia, Luqmani, Raashid, Mahr, Alfred, McAlear, Carol, Peck, Jacqueline, Shea, Beverley, Shea, Judy, Sreih, Antoine, Tugwell, Peter, and Merkel, Peter
Subjects: ANCA-ASSOCIATED VASCULITIS, ICF, OMERACT, PATIENT-REPORTED OUTCOMES, PROMIS, Algorithms, Anti-Inflammatory Agents, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Health Status, Humans, Patient Reported Outcome Measures, Quality of Life, Treatment Outcome
Abstract: OBJECTIVE: The antineutrophil cytoplasmic antibody-associated vasculitides (AAV) are multiorgan diseases. Patients with AAV report impairment in their health-related quality of life (HRQOL) and have different priorities regarding disease assessment compared with physicians. The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group previously received endorsement for a core set of domains in AAV. Two approaches to measure patient-reported outcomes (PRO) were presented at OMERACT 2016. METHODS: A novel 5-step tool was used to facilitate assessment of the instruments by delegates: the OMERACT Filter 2.0 Instrument Selection Algorithm, with a red-amber-green checklist of questions, including (1) good match with domain (face and content validity), (2) feasibility, (3) do numeric scores make sense (construct validity)?, (4) overall ratings of discrimination, and (5) can individual thresholds of meaning be defined? Delegates gave an overall endorsement. Three generic Patient-Reported Outcomes Measurement Information System (PROMIS) instruments (fatigue, physical functioning, and pain interference) and a disease-specific PRO, the AAV-PRO (6 domains related to symptoms and HRQOL), were presented. RESULTS: OMERACT delegates endorsed the use of the PROMIS instruments for fatigue, physical functioning, and pain interference (87.6% overall endorsement) and the disease-specific AAV-PRO instrument (89.4% overall endorsement). CONCLUSION: The OMERACT Vasculitis Working Group gained endorsement by OMERACT for use of the PROMIS and the AAV-PRO in clinical trials of vasculitis. These instruments are complementary to each other. The PROMIS and the AAV-PRO need further work to assess their utility in longitudinal settings, including their ability to discriminate between treatments of varying efficacy in the setting of a randomized controlled trial.
Published: 2017

384. The global ECT MRI collaboration: cognitive battery and prospective recommendations

Author: Maximilian Kiebs, Danielle Farrar, Erik Erhardt, and Christopher Abbott
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published: 2023
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385. Crystal structures and hydrogen-bonding analysis of a series of benzamide complexes of zinc(II) chloride

Author: Elizabeth Tinapple, Sam Farrar, and Dean H. Johnston
Subjects: ionic co-crystal, co-crystal salt, zinc(ii) chloride, benzamide, toluamide, Crystallography, QD901-999
Abstract: Ionic co-crystals are co-crystals between organic molecules and inorganic salt coformers. Co-crystals of pharmaceuticals are of interest to help control polymorph formation and potentially improve stability and other physical properties. We describe the preparation, crystal structures, and hydrogen bonding of five different 2:1 benzamide or toluamide/zinc(II) chloride co-crystal salts, namely, bis(benzamide-κO)dichloridozinc(II), [ZnCl2(C7H7NO)2], dichloridobis(2-methylbenzamide-κO)zinc(II), [ZnCl2(C8H9NO)2], dichloridobis(3-methylbenzamide-κO)zinc(II), [ZnCl2(C8H9NO)2], dichloridobis(4-methylbenzamide-κO)zinc(II), [ZnCl2(C8H9NO)2], and dichloridobis(4-hydroxybenzamide-κO)zinc(II), [ZnCl2(C7H7NO2)2]. All of the complexes contain hydrogen bonds between the amide N—H group and the amide carbonyl oxygen atoms or the chlorine atoms, forming extended networks.
Published: 2021
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386. Findings from the patch augmented rotator cuff surgery (PARCS) feasibility study

Author: Jonathan A. Cook, Mathew Baldwin, Cushla Cooper, Navraj S. Nagra, Joanna C. Crocker, Molly Glaze, Gemma Greenall, Amar Rangan, Lucksy Kottam, Jonathan L. Rees, Dair Farrar-Hockley, Naomi Merritt, Sally Hopewell, David Beard, Michael Thomas, Melina Dritsaki, and Andrew J. Carr
Subjects: Rotator cuff tear, Feasibility study, Shoulder surgery, Tissue scaffold, Surgical mesh, Dermal matrix, Medicine (General), R5-920
Abstract: Abstract Background A rotator cuff tear is a common disabling shoulder problem. Symptoms include pain, weakness, lack of mobility and sleep disturbance. Many patients require surgery to repair the tear; however, there is a high failure rate. There is a pressing need to improve the outcome of rotator cuff surgery. The use of patch augmentation to provide support to the healing process and improve patient outcomes holds new promise. Different materials (e.g. human/animal skin or intestine tissue, and completely synthetic materials) and processes (e.g. woven or a mesh) have been used to produce patches. However, clinical evidence on their use is limited. The patch augmented rotator cuff surgery (PARCS) feasibility study aimed to determine the design of a definitive randomised controlled trial (RCT) assessing the effectiveness and cost-effectiveness of a patch to augment surgical repair of the rotator cuff that is both acceptable to stakeholders and feasible. Methods A mixed methods feasibility study of conducing a subsequent RCT. The project involved six stages: a systematic review of clinical evidence; a survey of the British Elbow and Shoulder Society’s (BESS) surgical membership; a survey of surgeon trialists; focus groups and interviews with stakeholders; a two-round Delphi study administered via online questionnaires and a 2-day consensus meeting. Results The BESS surgeons’ survey identified a variety of patches in use (105 (21%) responses received). Twenty-four surgeons (77%) completed the trialist survey relating to trial design. Four focus groups were conducted involving 24 stakeholders. Twenty-nine (67% of invited) individuals took part in the Delphi. Differing views were held on a number of aspects including the appropriate patient population for trial participation. Agreement on the key research questions and the outline of two potential RCTs were achieved through the Delphi study and the consensus meeting. Conclusions Randomised comparisons of on-lay patch use for completed rotator cuff repairs, and bridging patch use for partial rotator cuff repairs were identified as areas for further research. The value of an observational study to assess safety concerns of patch use was also highlighted. The main limitation was that the findings were influenced by the participants, who might not necessarily reflect all stakeholders.
Published: 2021
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387. Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom

Author: Pritchard, Emma, Matthews, Philippa C., Stoesser, Nicole, Eyre, David W., Gethings, Owen, Vihta, Karina-Doris, Jones, Joel, House, Thomas, VanSteenHouse, Harper, Bell, Iain, Bell, John I., Newton, John N., Farrar, Jeremy, Diamond, Ian, Rourke, Emma, Studley, Ruth, Crook, Derrick, Peto, Tim E. A., Walker, A. Sarah, and Pouwels, Koen B.
Published: 2021
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388. The Association Between Vertical Equity and Presidential Voting Behavior and Taxpayers’ Compliance

Author: Farrar, Jonathan, Massey, Dawn W., Osecki, Errol, and Thorne, Linda
Published: 2021
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389. A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [18F]flutemetamol amyloid PET images

Author: Bucci, Marco, Savitcheva, Irina, Farrar, Gill, Salvadó, Gemma, Collij, Lyduine, Doré, Vincent, Gispert, Juan Domingo, Gunn, Roger, Hanseeuw, Bernard, Hansson, Oskar, Shekari, Mahnaz, Lhommel, Renaud, Molinuevo, José Luis, Rowe, Christopher, Sur, Cyrille, Whittington, Alex, Buckley, Christopher, and Nordberg, Agneta
Published: 2021
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390. Evidence for a mixed mass composition at the `ankle' in the cosmic-ray spectrum

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., del Peral, L., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Latronico, L., Lauscher, M., Lautridou, P., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Navas, S., Nellen, L., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollant, R., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento-Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valbuena-Delgado, A., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Younk, P., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report a first measurement for ultra-high energy cosmic rays of the correlation between the depth of shower maximum and the signal in the water Cherenkov stations of air-showers registered simultaneously by the fluorescence and the surface detectors of the Pierre Auger Observatory. Such a correlation measurement is a unique feature of a hybrid air-shower observatory with sensitivity to both the electromagnetic and muonic components. It allows an accurate determination of the spread of primary masses in the cosmic-ray flux. Up till now, constraints on the spread of primary masses have been dominated by systematic uncertainties. The present correlation measurement is not affected by systematics in the measurement of the depth of shower maximum or the signal in the water Cherenkov stations. The analysis relies on general characteristics of air showers and is thus robust also with respect to uncertainties in hadronic event generators. The observed correlation in the energy range around the `ankle' at $\lg(E/{\rm eV})=18.5-19.0$ differs significantly from expectations for pure primary cosmic-ray compositions. A light composition made up of proton and helium only is equally inconsistent with observations. The data are explained well by a mixed composition including nuclei with mass $A > 4$. Scenarios such as the proton dip model, with almost pure compositions, are thus disfavoured as the sole explanation of the ultrahigh-energy cosmic-ray flux at Earth., Comment: Published version. Added journal reference and DOI. Added Report Number
Published: 2016
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391. Search for ultrarelativistic magnetic monopoles with the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Nellen, L., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Machado, D. Torres, Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present a search for ultra-relativistic magnetic monopoles with the Pierre Auger Observatory. Such particles, possibly a relic of phase transitions in the early universe, would deposit a large amount of energy along their path through the atmosphere, comparable to that of ultrahigh-energy cosmic rays (UHECRs). The air shower profile of a magnetic monopole can be effectively distinguished by the fluorescence detector from that of standard UHECRs. No candidate was found in the data collected between 2004 and 2012, with an expected background of less than 0.1 event from UHECRs. The corresponding 90% confidence level (C.L.) upper limits on the flux of ultra-relativistic magnetic monopoles range from $10^{-19}$ (cm$^{2}$ sr s)$^{-1}$ for a Lorentz factor $\gamma=10^9$ to $2.5 \times10^{-21}$ (cm$^{2}$ sr s)$^{-1}$ for $\gamma=10^{12}$. These results - the first obtained with a UHECR detector - improve previously published limits by up to an order of magnitude., Comment: Published version. Corrected title. Added journal reference and DOI. Added Report Number
Published: 2016
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392. Ultrahigh-energy neutrino follow-up of Gravitational Wave events GW150914 and GW151226 with the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Luz, R. J. Barreira, Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., García, B., Garcia-Pinto, D., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gorgi, A., Gorham, P., Gouffon, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Lauscher, M., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Nellen, L., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rogozin, D., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Elipe, G. Torralba, Machado, D. Torres, Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: On September 14, 2015 the Advanced LIGO detectors observed their first gravitational-wave (GW) transient GW150914. This was followed by a second GW event observed on December 26, 2015. Both events were inferred to have arisen from the merger of black holes in binary systems. Such a system may emit neutrinos if there are magnetic fields and disk debris remaining from the formation of the two black holes. With the surface detector array of the Pierre Auger Observatory we can search for neutrinos with energy above 100 PeV from point-like sources across the sky with equatorial declination from about -65 deg. to +60 deg., and in particular from a fraction of the 90% confidence-level (CL) inferred positions in the sky of GW150914 and GW151226. A targeted search for highly-inclined extensive air showers, produced either by interactions of downward-going neutrinos of all flavors in the atmosphere or by the decays of tau leptons originating from tau-neutrino interactions in the Earth's crust (Earth-skimming neutrinos), yielded no candidates in the Auger data collected within $\pm 500$ s around or 1 day after the coordinated universal time (UTC) of GW150914 and GW151226, as well as in the same search periods relative to the UTC time of the GW candidate event LVT151012. From the non-observation we constrain the amount of energy radiated in ultrahigh-energy neutrinos from such remarkable events., Comment: Published version. Added journal reference and DOI. Added Report Number
Published: 2016
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393. Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

Author: The Pierre Auger Collaboration, Aab, Alexander, Abreu, Pedro, Aglietta, Marco, Ahn, Eun-Joo, Samarai, Imen Al, Albuquerque, Ivone, Allekotte, Ingomar, Allison, Patrick, Almela, Alejandro, Castillo, Jesus Alvarez, Alvarez-Muñiz, Jaime, Batista, Rafael Alves, Ambrosio, Michelangelo, Aminaei, Amin, Anastasi, Gioacchino Alex, Anchordoqui, Luis, Andringa, Sofia, Aramo, Carla, Arqueros, Fernando, Arsene, Nicusor, Asorey, Hernán Gonzalo, Assis, Pedro, Aublin, Julien, Avila, Gualberto, Awal, Nafiun, Badescu, Alina Mihaela, Baus, Colin, Beatty, Jim, Becker, Karl Heinz, Bellido, Jose A., Berat, Corinne, Bertaina, Mario Edoardo, Bertou, Xavier, Biermann, Peter, Billoir, Pierre, Blaess, Simon G., Blanco, Alberto, Blanco, Miguel, Blazek, Jiri, Bleve, Carla, Blümer, Hans, Boháčová, Martina, Boncioli, Denise, Bonifazi, Carla, Borodai, Nataliia, Brack, Jeffrey, Brancus, Iliana, Bretz, Thomas, Bridgeman, Ariel, Brogueira, Pedro, Buchholz, Peter, Bueno, Antonio, Buitink, Stijn, Buscemi, Mario, Caballero-Mora, Karen S., Caccianiga, Barbara, Caccianiga, Lorenzo, Candusso, Marina, Caramete, Laurentiu, Caruso, Rossella, Castellina, Antonella, Cataldi, Gabriella, Cazon, Lorenzo, Cester, Rosanna, Chavez, Alan G., Chiavassa, Andrea, Chinellato, Jose Augusto, Chudoba, Jiri, Cilmo, Marco, Clay, Roger W, Cocciolo, Giuseppe, Colalillo, Roberta, Coleman, Alan, Collica, Laura, Coluccia, Maria Rita, Conceição, Ruben, Contreras, Fernando, Cooper, Mathew J., Cordier, Alain, Coutu, Stephane, Covault, Corbin, Cronin, James, Dallier, Richard, Daniel, Bruno, Dasso, Sergio, Daumiller, Kai, Dawson, Bruce R., de Almeida, Rogerio M., de Jong, Sijbrand J., De Mauro, Giuseppe, Neto, Joao de Mello, De Mitri, Ivan, de Oliveira, Jaime, de Souza, Vitor, del Peral, Luis, Deligny, Olivier, Dhital, Niraj, Di Giulio, Claudio, Di Matteo, Armando, Diaz, Johana Chirinos, Castro, Mary Lucia Díaz, Diogo, Francisco, Dobrigkeit, Carola, Docters, Wendy, D'Olivo, Juan Carlos, Dorofeev, Alexei, Hasankiadeh, Qader Dorosti, Anjos, Rita dos, Dova, Maria Teresa, Ebr, Jan, Engel, Ralph, Erdmann, Martin, Erfani, Mona, Escobar, Carlos O., Espadanal, Joao, Etchegoyen, Alberto, Falcke, Heino, Fang, Ke, Farrar, Glennys, Fauth, Anderson, Fazzini, Norberto, Ferguson, Andrew P., Fick, Brian, Figueira, Juan Manuel, Filevich, Alberto, Filipčič, Andrej, Fratu, Octavian, Freire, Martín Miguel, Fujii, Toshihiro, García, Beatriz, Garcia-Gamez, Diego, Garcia-Pinto, Diego, Gate, Florian, Gemmeke, Hartmut, Gherghel-Lascu, Alexandru, Ghia, Piera Luisa, Giaccari, Ugo, Giammarchi, Marco, Giller, Maria, Głas, Dariusz, Glaser, Christian, Glass, Henry, Golup, Geraldina, Berisso, Mariano Gómez, Vitale, Primo F. Gómez, González, Nicolás, Gookin, Ben, Gordon, Jacob, Gorgi, Alessio, Gorham, Peter, Gouffon, Philippe, Griffith, Nathan, Grillo, Aurelio, Grubb, Trent D., Guarino, Fausto, Guedes, Germano, Hampel, Matías Rolf, Hansen, Patricia, Harari, Diego, Harrison, Thomas A., Hartmann, Sebastian, Harton, John, Haungs, Andreas, Hebbeker, Thomas, Heck, Dieter, Heimann, Philipp, Herve, Alexander E., Hill, Gary C., Hojvat, Carlos, Hollon, Nicholas, Holt, Ewa, Homola, Piotr, Hörandel, Jörg, Horvath, Pavel, Hrabovský, Miroslav, Huber, Daniel, Huege, Tim, Insolia, Antonio, Isar, Paula Gina, Jandt, Ingolf, Jansen, Stefan, Jarne, Cecilia, Johnsen, Jeffrey A., Josebachuili, Mariela, Kääpä, Alex, Kambeitz, Olga, Kampert, Karl Heinz, Kasper, Peter, Katkov, Igor, Keilhauer, Bianca, Kemp, Ernesto, Kieckhafer, Roger, Klages, Hans, Kleifges, Matthias, Kleinfeller, Jonny, Krause, Raphael, Krohm, Nicole, Kuempel, Daniel, Mezek, Gasper Kukec, Kunka, Norbert, Awad, Alaa Metwaly Kuotb, LaHurd, Danielle, Latronico, Luca, Lauer, Robert, Lauscher, Markus, Lautridou, Pascal, Coz, Sandra Le, Lebrun, Didier, Lebrun, Paul, de Oliveira, Marcelo Augusto Leigui, Letessier-Selvon, Antoine, Lhenry-Yvon, Isabelle, Link, Katrin, Lopes, Luis, López, Rebeca, Casado, Aida López, Louedec, Karim, Lucero, Agustin, Malacari, Max, Mallamaci, Manuela, Maller, Jennifer, Mandat, Dusan, Mantsch, Paul, Mariazzi, Analisa, Marin, Vincent, Mariş, Ioana, Marsella, Giovanni, Martello, Daniele, Martinez, Humberto, Bravo, Oscar Martínez, Martraire, Diane, Meza, Jimmy Masías, Mathes, Hermann-Josef, Mathys, Sebastian, Matthews, James, Matthews, John, Matthiae, Giorgio, Maurizio, Daniela, Mayotte, Eric, Mazur, Peter, Medina, Carlos, Medina-Tanco, Gustavo, Meissner, Rebecca, Mello, Victor, Melo, Diego, Menshikov, Alexander, Messina, Stefano, Micheletti, Maria Isabel, Middendorf, Lukas, Minaya, Ignacio A., Miramonti, Lino, Mitrica, Bogdan, Molina-Bueno, Laura, Mollerach, Silvia, Montanet, François, Morello, Carlo, Mostafá, Miguel, Moura, Celio A., Muller, Marcio Aparecido, Müller, Gero, Müller, Sarah, Navas, Sergio, Necesal, Petr, Nellen, Lukas, Nelles, Anna, Neuser, Jens, Nguyen, Phong H., Niculescu-Oglinzanu, Mihai, Niechciol, Marcus, Niemietz, Lukas, Niggemann, Tim, Nitz, Dave, Nosek, Dalibor, Novotny, Vladimir, Nožka, Lyberis, Núñez, Luis, Ochilo, Livingstone, Oikonomou, Foteini, Olinto, Angela, Pacheco, Noelia, Selmi-Dei, Daniel Pakk, Palatka, Miroslav, Pallotta, Juan, Papenbreer, Philipp, Parente, Gonzalo, Parra, Alejandra, Paul, Thomas, Pech, Miroslav, Pękala, Jan, Pelayo, Rodrigo, Pepe, Iuri, Perrone, Lorenzo, Petermann, Emily, Peters, Christine, Petrera, Sergio, Petrov, Yevgeniy, Phuntsok, Jamyang, Piegaia, Ricardo, Pierog, Tanguy, Pieroni, Pablo, Pimenta, Mário, Pirronello, Valerio, Platino, Manuel, Plum, Matthias, Porcelli, Alessio, Porowski, Czeslaw, Prado, Raul Ribeiro, Privitera, Paolo, Prouza, Michael, Quel, Eduardo J, Querchfeld, Sven, Quinn, Sean, Rautenberg, Julian, Ravel, Olivier, Ravignani, Diego, Reinert, Darius, Revenu, Benoît, Ridky, Jan, Risse, Markus, Ristori, Pablo, Rizi, Vincenzo, de Carvalho, Washington Rodrigues, Rojo, Jorge Rubén Rodriguez, Rodríguez-Frías, Maria Dolores, Rogozin, Dmytro, Rosado, Jaime, Roth, Markus, Roulet, Esteban, Rovero, Adrian, Saffi, Steven J., Saftoiu, Alexandra, Salazar, Humberto, Saleh, Ahmed, Greus, Francisco Salesa, Salina, Gaetano, Gomez, Jose Sanabria, Sánchez, Federico, Sanchez-Lucas, Patricia, Santos, Edivaldo Moura, Santos, Eva, Sarazin, Fred, Sarkar, Biswaijt, Sarmento, Raul, Sarmiento-Cano, Christian, Sato, Ricardo, Scarso, Carlos, Schauer, Markus, Scherini, Viviana, Schieler, Harald, Schmidt, David, Scholten, Olaf, Schoorlemmer, Harm, Schovánek, Petr, Schröder, Frank G., Schulz, Alexander, Schulz, Johannes, Schumacher, Johannes, Sciutto, Sergio, Segreto, Alberto, Settimo, Mariangela, Shadkam, Amir, Shellard, Ronald C., Sigl, Guenter, Sima, Octavian, Śmiałkowski, Andrzej, Šmída, Radomir, Snow, Gregory, Sommers, Paul, Sonntag, Sebastian, Sorokin, J., Squartini, Ruben, Srivastava, Yogendra N., Stanca, Denis, Stanič, Samo, Stapleton, James, Stasielak, Jaroslaw, Stephan, Maurice, Stutz, Anne, Suarez, Federico, Durán, Mauricio Suarez, Suomijärvi, Tiina, Supanitsky, A. Daniel, Sutherland, Michael, Swain, John, Szadkowski, Zbigniew, Taborda, Oscar Alejandro, Tapia, Alex, Tepe, Andreas, Theodoro, Vanessa Menezes, Timmermans, Charles, Peixoto, Carlos J. Todero, Toma, Gabriel, Tomankova, Lenka, Tomé, Bernardo, Tonachini, Aurelio, Elipe, Guillermo Torralba, Machado, Diego Torres, Travnicek, Petr, Trini, Marta, Ulrich, Ralf, Unger, Michael, Urban, Martin, Galicia, Jose F. Valdés, Valiño, Ines, Valore, Laura, van Aar, Guus, van Bodegom, Patrick, Berg, Ad M. van den, van Velzen, Sjoert, van Vliet, Arjen, Varela, Enrique, Cárdenas, Bernardo Vargas, Varner, Gary, Vasquez, Rafael, Vázquez, Jose R., Vázquez, Ricardo, Veberič, Darko, Verzi, Valerio, Vicha, Jakub, Videla, Mariela, Villaseñor, Luis, Vlcek, Brian, Vorobiov, Serguei, Wahlberg, Hernan, Wainberg, Oscar, Walz, David, Watson, Alan, Weber, Marc, Weidenhaupt, Klaus, Weindl, Andreas, Welling, Christoph, Werner, Felix, Widom, Allan, Wiencke, Lawrence, Wilczyński, Henryk, Winchen, Tobias, Wittkowski, David, Wundheiler, Brian, Wykes, Sarka, Yang, Lili, Yapici, Tolga, Yushkov, Alexey, Zas, Enrique, Zavrtanik, Danilo, Zavrtanik, Marko, Zepeda, Arnulfo, Zimmermann, Benedikt, Ziolkowski, Michael, and Zuccarello, Francesca
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory., Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary files
Published: 2016
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394. Prototype muon detectors for the AMIGA component of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Batista, R. Alves, Ambrosio, M., Aminaei, A., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Awal, N., Badescu, A. M., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Blaess, S. G., Blanco, A., Blanco, M., Blazek, J., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Brogueira, P., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Candusso, M., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Cilmo, M., Clay, R. W., Cocciolo, G., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Cordier, A., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., del Peral, L., Deligny, O., Dhital, N., Di Giulio, C., Di Matteo, A., Diaz, J. C., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dorofeev, A., Hasankiadeh, Q. Dorosti, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gallo, F., García, B., García-Gámez, D., Garcia-Pinto, D., Gate, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Hartmann, S., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Hervé, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huber, D., Huege, T., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. W. Kuotb, LaHurd, D., Latronico, L., Lauer, R., Lauscher, M., Lautridou, P., Coz, S. Le, Lebrun, D., Lebrun, P., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Louedec, K., Lucero, A., Malacari, M., Mallamaci, M., Maller, J., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Martraire, D., Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Meissner, R., Mello, V. B. B., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. A., Muller, M. A., Müller, G., Müller, S., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pękala, J., Pelayo, R., Pepe, I. M., Perrone, L., Petermann, E., Peters, C., Petrera, S., Petrov, Y., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porcelli, A., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento-Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Srivastava, Y. N., Stanca, D., Stanič, S., Stapleton, J., Stasielak, J., Stephan, M., Stutz, A., Suarez, F., Durán, M. Suarez, Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Tibolla, O., Timmermans, C., Peixoto, C. J. Todero, Toma, G., Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Velzen, S., van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vasquez, R., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Vlcek, B., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weidenhaupt, K., Weindl, A., Werner, F., Widom, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yapici, T., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., and Zuccarello, F.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Auger Muons and Infill for the Ground Array) is an upgrade of the Pierre Auger Observatory to extend its range of detection and to directly measure the muon content of the particle showers. It consists of an infill of surface water-Cherenkov detectors accompanied by buried scintillator detectors used for muon counting. The main objectives of the AMIGA engineering array, referred to as the Unitary Cell, are to identify and resolve all engineering issues as well as to understand the muon-number counting uncertainties related to the design of the detector. The mechanical design, fabrication and deployment processes of the muon counters of the Unitary Cell are described in this document. These muon counters modules comprise sealed PVC casings containing plastic scintillation bars, wavelength-shifter optical fibers, 64 pixel photomultiplier tubes, and acquisition electronics. The modules are buried approximately 2.25 m below ground level in order to minimize contamination from electromagnetic shower particles. The mechanical setup, which allows access to the electronics for maintenance, is also described in addition to tests of the modules' response and integrity. The completed Unitary Cell has measured a number of air showers of which a first analysis of a sample event is included here., Comment: Replaced with published version. Added journal reference and DOI
Published: 2016
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395. The Pierre Auger Observatory Upgrade - Preliminary Design Report

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Batista, R. Alves, Ambrosio, M., Aminaei, A., Anchordoqui, L., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Ave, M., Avenier, M., Avila, G., Awal, N., Badescu, A. M., Barber, K. B., Bäuml, J., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Blaess, S. G., Blanco, A., Blanco, M., Blazek, J., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Brack, J., Brancus, I., Bridgeman, A., Brogueira, P., Brown, W. C., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Candusso, M., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Cilmo, M., Clay, R. W., Cocciolo, G., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Cordier, A., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., del Peral, L., Deligny, O., Dembinski, H., Dhital, N., Di Giulio, C., Di Matteo, A., Diaz, J. C., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dorofeev, A., Hasankiadeh, Q. Dorosti, Dova, M. T., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fernandes, M., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fox, B. D., Fratu, O., Freire, M. M., Fuchs, B., Fujii, T., García, B., Garcia-Pinto, D., Gate, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Hartmann, S., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Hemery, N., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huber, D., Huege, T., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Kégl, B., Keilhauer, B., Keivani, A., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Krömer, O., Kuempel, D., Mezek, G. Kukec, Kunka, N., LaHurd, D., Latronico, L., Lauer, R., Lauscher, M., Lautridou, P., Coz, S. Le, Lebrun, D., Lebrun, P., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Louedec, K., Lu, L., Lucero, A., Malacari, M., Maldera, S., Mallamaci, M., Maller, J., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martin, L., Martinez, H., Bravo, O. Martínez, Martraire, D., Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Meissner, R., Mello, V. B. B., Melo, D., Menshikov, A., Messina, S., Meyhandan, R., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. A., Muller, M. A., Müller, G., Müller, S., Mussa, R., Navarra, G., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Ochilo, L., Oikonomou, F., Olinto, A., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pȩkala, J., Pelayo, R., Pepe, I. M., Perrone, L., Petermann, E., Peters, C., Petrera, S., Petrov, Y., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porcelli, A., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Purrello, V., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, D., Revenu, B., Ridky, J., Riggi, S., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Sánchez, F., Sanchez-Lucas, P., Santos, E., Santos, E. M., Sarazin, F., Sarkar, B., Sarmento, R., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sidelnik, I., Sigl, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sorokin, J., Squartini, R., Srivastava, Y. N., Stanca, D., Stanič, S., Stapleton, J., Stasielak, J., Stephan, M., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Toma, G., Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Velzen, S., van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vasquez, R., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Vlcek, B., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weidenhaupt, K., Weindl, A., Werner, F., Widom, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yapici, T., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zhu, Y., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The Pierre Auger Observatory has begun a major Upgrade of its already impressive capabilities, with an emphasis on improved mass composition determination using the surface detectors of the Observatory. Known as AugerPrime, the upgrade will include new 4 m$^2$ plastic scintillator detectors on top of all 1660 water-Cherenkov detectors, updated and more flexible surface detector electronics, a large array of buried muon detectors, and an extended duty cycle for operations of the fluorescence detectors. This Preliminary Design Report was produced by the Collaboration in April 2015 as an internal document and information for funding agencies. It outlines the scientific and technical case for AugerPrime. We now release it to the public via the arXiv server. We invite you to review the large number of fundamental results already achieved by the Observatory and our plans for the future., Comment: 201 pages
Published: 2016

396. Azimuthal asymmetry in the risetime of the surface detector signals of the Pierre Auger Observatory

Author: The Pierre Auger Collaboration, Aab, A., Abreu, P., Aglietta, M., Ahn, E. J., Samarai, I. Al, Albuquerque, I. F. M., Allekotte, I., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Awal, N., Badescu, A. M., Baus, C., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., Dallier, R., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., del Peral, L., Deligny, O., Dhital, N., Di Giulio, C., Di Matteo, A., Castro, M. L. Díaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorofeev, A., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gallo, F., García, B., Garcia-Pinto, D., Gate, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glaser, C., Glass, H., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Griffith, N., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Hasankiadeh, Q., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Holt, E., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Jarne, C., Johnsen, J. A., Josebachuili, M., Kääpä, A., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, LaHurd, D., Latronico, L., Lauscher, M., Lautridou, P., Lebrun, P., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., López, R., Casado, A. López, Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martínez, Meza, J. J. Masías, Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Mello, V. B. B., Melo, D., Menshikov, A., Messina, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Moura, C. A., Müller, G., Muller, M. A., Müller, S., Naranjo, I., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pepe, I. M., Pereira, L. A. S., Perrone, L., Petermann, E., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Rodríguez-Frías, M. D., Rogozin, D., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Greus, F. Salesa, Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarkar, B., Sarmento, R., Sarmiento-Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanič, S., Stapleton, J., Stasielak, J., Strafella, F., Stutz, A., Suarez, F., Durán, M. Suarez, Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tomé, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valbuena-Delgado, A., Galicia, J. F. Valdés, Valiño, I., Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cárdenas, B. Vargas, Varner, G., Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yapici, T., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., and Zuccarello, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The azimuthal asymmetry in the risetime of signals in Auger surface detector stations is a source of information on shower development. The azimuthal asymmetry is due to a combination of the longitudinal evolution of the shower and geometrical effects related to the angles of incidence of the particles into the detectors. The magnitude of the effect depends upon the zenith angle and state of development of the shower and thus provides a novel observable, $(\sec \theta)_\mathrm{max}$, sensitive to the mass composition of cosmic rays above $3 \times 10^{18}$ eV. By comparing measurements with predictions from shower simulations, we find for both of our adopted models of hadronic physics (QGSJETII-04 and EPOS-LHC) an indication that the mean cosmic-ray mass increases slowly with energy, as has been inferred from other studies. However, the mass estimates are dependent on the shower model and on the range of distance from the shower core selected. Thus the method has uncovered further deficiencies in our understanding of shower modelling that must be resolved before the mass composition can be inferred from $(\sec \theta)_\mathrm{max}$., Comment: Replaced with published version. Added journal reference and DOI
Published: 2016
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397. Is ἐκεῖ ἔσται ὁ κλαυθμὸς καὶ ὁ βρυγμὸς τῶν ὀδόντων in the Gospels a Funerary Formula?

Author: Thomas Farrar
Subjects: The Bible, BS1-2970
Abstract: N/A
Published: 2022
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398. Acupuncture versus massage for pain in patients living with advanced cancer: a protocol for the IMPACT randomised clinical trial

Author: Han Xiao, Katherine Panageas, Jun J Mao, Kevin Liou, Sally A D Romero, Nicholas Emard, Raymond E Baser, Jodi MacLeod, Desiree Walker, Margaret Barton-Burke, Gary Deng, John Farrar, and Andrew Epstein
Subjects: Medicine
Abstract: Introduction Pain, comorbid fatigue and sleep disturbances are common and distressing symptoms for patients with advanced cancer, negatively impacting their quality of life. Clinical guidelines recommend non-pharmacological interventions, including acupuncture and massage, for pain management in adult patients with cancer in adjunct to conventional care. However, high-quality evidence about the comparative effectiveness and long-term durability of these therapies for symptom management is limited.Methods and analysis We describe the design of a two-arm, parallel group, multicentre randomised controlled trial that investigates the use of acupuncture versus massage for musculoskeletal pain among 300 patients with diverse types of advanced cancer. The primary aim is to evaluate the long-term effectiveness (26 weeks from randomisation) of acupuncture vs massage for pain (primary outcome) and comorbid symptoms (fatigue, sleep disturbance and quality of life). The secondary aim is to identify patient-level demographic characteristics (eg, sex, race, age), clinical factors (eg, insomnia, pain severity) and psychological attributes that are associated with a greater reduction in pain for either acupuncture or massage. Patients will receive weekly acupuncture or massage treatments for 10 weeks, followed by monthly booster sessions up to 26 weeks. The primary endpoint will be the change in worst pain intensity score from baseline to 26 weeks. We will collect validated patient-reported outcomes at multiple time points over 26 weeks.Ethics and dissemination The Institutional Review Board at Memorial Sloan Kettering Cancer Center in New York approved this protocol. Results will be disseminated via peer-reviewed scientific journals and conference presentations. Our findings will help patients and healthcare providers make informed decisions about incorporating non-pharmacological treatments to manage pain for patients with advanced cancer.Trial registration number NCT04095234.
Published: 2022
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399. AAV‐mediated gene therapy improving mitochondrial function provides benefit in age‐related macular degeneration models

Author: Sophia Millington‐Ward, Naomi Chadderton, Laura K. Finnegan, Iris J.M. Post, Matthew Carrigan, Tom Gardiner, Elisa Peixoto, Daniel Maloney, Marian M. Humphries, Alan Stitt, Thierry Léveillard, Pete Humphries, Paul F. Kenna, Arpad Palfi, and G. Jane Farrar
Subjects: Medicine (General), R5-920
Published: 2022
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400. An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism

Author: Zengdi Zhang, Oscar C. Salgado, Bing Liu, Zahra Moazzami, Kristin A. Hogquist, Michael A. Farrar, and Hai-Bin Ruan
Subjects: O-GlcNAc, Treg - regulatory T cell, iron, fatty acid uptake, adipose tissue, Immunologic diseases. Allergy, RC581-607
Abstract: The immunosuppressive regulatory T (Treg) cells exert emerging effects on adipose tissue homeostasis and systemic metabolism. However, the metabolic regulation and effector mechanisms of Treg cells in coping with obesogenic insults are not fully understood. We have previously established an indispensable role of the O-linked N-Acetylglucosamine (O-GlcNAc) signaling in maintaining Treg cell identity and promoting Treg suppressor function, via STAT5 O-GlcNAcylation and activation. Here, we investigate the O-GlcNAc transferase (OGT)-STAT5 axis in driving the immunomodulatory function of Treg cells for metabolic homeostasis. Treg cell-specific OGT deficiency renders mice more vulnerable to high-fat diet (HFD)-induced adiposity and insulin resistance. Conversely, constitutive STAT5 activation in Treg cells confers protection against adipose tissue expansion and impaired glucose and insulin metabolism upon HFD feeding, in part by suppressing adipose lipid uptake and redistributing systemic iron storage. Treg cell function can be augmented by targeting the OGT-STAT5 axis to combat obesity and related metabolic disorders.
Published: 2022
Full Text: View/download PDF

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