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Purpose To assess the performance of deep learning algorithms for different tasks in retinal fundus images: (1) detection of retinal fundus images versus optical coherence tomography (OCT) or other images, (2) evaluation of good quality retinal fundus images, (3) distinction between right eye (OD) and left eye (OS) retinal fundus images,(4) detection of age-related macular degeneration (AMD) and (5) detection of referable glaucomatous optic neuropathy (GON). Patients and methods Five algorithms were designed. Retrospective study from a database of 306,302 images, Optretina's tagged dataset. Three different ophthalmologists, all retinal specialists, classified all images. The dataset was split per patient in a training (80%) and testing (20%) splits. Three different CNN architectures were employed, two of which were custom designed to minimize the number of parameters with minimal impact on its accuracy. Main outcome measure was area under the curve (AUC) with accuracy, sensitivity and specificity. Results Determination of retinal fundus image had AUC of 0.979 with an accuracy of 96% (sensitivity 97.7%, specificity 92.4%). Determination of good quality retinal fundus image had AUC of 0.947, accuracy 91.8% (sensitivity 96.9%, specificity 81.8%). Algorithm for OD/OS had AUC 0.989, accuracy 97.4%. AMD had AUC of 0.936, accuracy 86.3% (sensitivity 90.2% specificity 82.5%), GON had AUC of 0.863, accuracy 80.2% (sensitivity 76.8%, specificity 83.8%). Conclusion Deep learning algorithms can differentiate a retinal fundus image from other images. Algorithms can evaluate the quality of an image, discriminate between right or left eye and detect the presence of AMD and GON with a high level of accuracy, sensitivity and specificity.

The current state of the art for image annotation and image retrieval tasks is obtained through deep neural network multimodal pipelines, which combine an image representation and a text representation into a shared embedding space. In this paper we evaluate the impact of using the Full-Network embedding (FNE) in this setting, replacing the original image representation in four competitive multimodal embedding generation schemes. Unlike the one-layer image embeddings typically used by most approaches, the Full-Network embedding provides a multi-scale discrete representation of images, which results in richer characterisations. Extensive testing is performed on three different datasets comparing the performance of the studied variants and the impact of the FNE on a levelled playground, i.e., under equality of data used, source CNN models and hyper-parameter tuning. The results obtained indicate that the Full-Network embedding is consistently superior to the one-layer embedding. Furthermore, its impact on performance is superior to the improvement stemming from the other variants studied. These results motivate the integration of the Full-Network embedding on any multimodal embedding generation scheme. This work is partially supported by the Joint Study Agreement no. W156463 under the IBM/BSC Deep Learning Center agreement, by the Spanish Government through Programa Severo Ochoa (SEV-2015- 0493), by the Spanish Ministry of Science and Technology through TIN2015-65316-P project and by the Generalitat de Catalunya (contracts 2014-SGR-1051), and by the Core Research for Evolutional Science and Technology (CREST) program of Japan Science and Technology Agency (JST).

Asymmetric multi-cores (AMCs) are a successful architectural solution for both mobile devices and supercomputers. By maintaining two types of cores (fast and slow) AMCs are able to provide high performance under the facility power budget. This paper performs the first extensive evaluation of how portable are the current HPC applications for such supercomputing systems. Specifically we evaluate several execution models on an ARM big.LITTLE AMC using the PARSEC benchmark suite that includes representative highly parallel applications. We compare schedulers at the user, OS and runtime levels, using both static and dynamic options and multiple configurations, and assess the impact of these options on the well-known problem of balancing the load across AMCs. Our results demonstrate that scheduling is more effective when it takes place in the runtime system level as it improves the baseline by 23%, while the heterogeneous-aware OS scheduling solution improves the baseline by 10%., This work has been supported by the RoMoL ERC Advanced Grant (GA 321253), by the European HiPEAC Network of Excellence, by the Spanish Ministry of Science and Innovation (contracts TIN2015-65316-P), by the Generalitat de Catalunya (contracts 2014-SGR-1051 and 2014-SGR-1272), and by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 671697 and No. 779877. Kallia Chronaki has been partially supported by the Ministry of Economy and Competitiveness under Ramon y Cajal fellowship number RYC-2016-21104.