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159 results on '"Economides, Aris N"'

151. Patent Issued for Method For Making A Genetically Modified Mouse With An Inducible ACVR1 Mutation That Causes Ectopic Bone Formation (USPTO 10,470,444)

Subjects
Regeneron Pharmaceuticals Inc. -- Intellectual property, Genetically modified organisms -- Methods -- Genetic aspects, Amino acids -- Methods -- Genetic aspects, Pharmaceutical industry -- Intellectual property -- Methods, Proteins -- Methods -- Genetic aspects, House mouse -- Methods -- Genetic aspects, Animal genetic engineering, Biotechnology, Editors, Biotechnology industry, Pharmaceuticals and cosmetics industries
Abstract

2019 NOV 27 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Week -- A patent by the inventors Economides, Aris N. (Tarrytown, NY); Hatsell, Sarah Jane (Nyack, NY), [...]

Published
2019

152. Patent Issued for Rodent Embryonic Stem Cell With Conditional ACVR1 Mutant Alleles (USPTO 10,448,621)

Subjects
Regeneron Pharmaceuticals Inc. -- Intellectual property -- Reports, Embryonic stem cells -- Reports -- Genetic aspects, Genes -- Reports -- Genetic aspects, Gene mutation -- Reports -- Genetic aspects, Amino acids -- Reports -- Genetic aspects, Pharmaceutical industry -- Intellectual property -- Reports, Proteins -- Reports -- Genetic aspects, Alleles, Animal genetic engineering, Biotechnology, Editors, Biotechnology industry, Pharmaceuticals and cosmetics industries
Abstract

2019 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Week -- From Alexandria, Virginia, NewsRx journalists report that a patent by the inventors Economides, Aris N. [...]

Published
2019

155. Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression.

Author

Sebastian, Aimy, Chang, Jiun C., Mendez, Melanie E., Murugesh, Deepa K., Hatsell, Sarah, Economides, Aris N., Christiansen, Blaine A., and Loots, Gabriela G.

Subjects
*ANTERIOR cruciate ligament, *OSTEOARTHRITIS, *GENE expression, *RNA sequencing, *CYTOKINES, *ENZYMES
Abstract

Anterior cruciate ligament (ACL) injuries often result in post-traumatic osteoarthritis (PTOA). To better understand the molecular mechanisms behind PTOA development following ACL injury, we profiled ACL injury-induced transcriptional changes in knee joints of three mouse strains with varying susceptibility to OA: STR/ort (highly susceptible), C57BL/6J (moderately susceptible) and super-healer MRL/MpJ (not susceptible). Right knee joints of the mice were injured using a non-invasive tibial compression injury model and global gene expression was quantified before and at 1-day, 1-week, and 2-weeks post-injury using RNA-seq. Following injury, injured and uninjured joints of STR/ort and injured C57BL/6J joints displayed significant cartilage degeneration while MRL/MpJ had little cartilage damage. Gene expression analysis suggested that prolonged inflammation and elevated catabolic activity in STR/ort injured joints, compared to the other two strains may be responsible for the severe PTOA phenotype observed in this strain. MRL/MpJ had the lowest expression values for several inflammatory cytokines and catabolic enzymes activated in response to ACL injury. Furthermore, we identified several genes highly expressed in MRL/MpJ compared to the other two strains including B4galnt2 and Tpsab1 which may contribute to enhanced healing in the MRL/MpJ. Overall, this study has increased our knowledge of early molecular changes associated with PTOA development. [ABSTRACT FROM AUTHOR]

Published
2018
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156. Patent Issued for Method for Detecting the Replacement of an Endogenous Allele with a Modified Allele by Homologous Recombination in a Mouse ES Cell (USPTO 9677129)

Subjects
Regeneron Pharmaceuticals Inc. -- Intellectual property, Biotechnology -- Methods, Anopheles -- Methods, Patents -- Methods, Pharmaceutical industry -- Intellectual property -- Methods, Patent/copyright issue, Biotechnology industry, Biological sciences, Business
Abstract

2017 JUN 26 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech Business Week -- A patent by the inventors Economides, Aris N. (Tarrytown, NY); Murphy, Andrew J. (Croton-On-Hudson, [...]

Published
2017

157. Researchers Submit Patent Application, 'Compositions and Methods for Modifying Cells', for Approval

Subjects
Regeneron Pharmaceuticals Inc. -- Intellectual property, Biochemistry -- Methods, Patents -- Methods, Pharmaceutical industry -- Intellectual property -- Methods, Patent/copyright issue, Business, Pharmaceuticals and cosmetics industries, Health
Abstract

By a News Reporter-Staff News Editor at Pharma Business Week -- From Washington, D.C., NewsRx journalists report that a patent application by the inventors ECONOMIDES, ARIS N. (Tarrytown, NY); Murphy, [...]

Published
2014

158. Patent Issued for Method for Genetically Modifying Mouse Embryonic Stem Cell by Homologous Recombination

Subjects
Regeneron Pharmaceuticals Inc. -- Intellectual property, Embryonic stem cells -- Methods, Patents -- Methods, Mice -- Methods, Genetically modified organisms -- Methods, Pharmaceutical industry -- Intellectual property -- Methods, Patent/copyright issue, Business, Pharmaceuticals and cosmetics industries, Health
Abstract

By a News Reporter-Staff News Editor at Pharma Business Week -- A patent by the inventors Economides, Aris N. (Tarrytown, NY); Murphy, Andrew J. (Croton-on Hudson, NY); Valenzuela, David M. [...]

Published
2014

159. 'Methods of Modifying Eukaryotic Cells' in Patent Application Approval Process

Subjects
Regeneron Pharmaceuticals Inc. -- Intellectual property, Patents -- Methods, Pharmaceutical industry -- Intellectual property -- Methods, Patent/copyright issue, Biological sciences, Health
Abstract

By a News Reporter-Staff News Editor at Life Science Weekly -- A patent application by the inventors Economides, Aris N. (Tarrytown, NY); Murphy, Andrew J. (Croton-on-Hudson, NY); Valenzuela, David M. [...]

Published
2013

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