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351. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

352. Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: A retrospective multicohort analysis

356. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

357. The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

358. PDCT-09. HYPERMUTATION AND NEOANTIGEN FORMATION IS DIAGNOSTIC AND PREDICT RESPONSE TO IMMUNE CHECKPOINT INHIBITION IN CHILDHOOD BIALLELIC MISMATCH REPAIR DEFICIENT BRAIN TUMORS

359. Association Between Prolonged Seizures and Malignant Middle Cerebral Artery Infarction in Children With Acute Ischemic Stroke

360. Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

362. Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency

364. LG-66CLINICAL AND TREATMENT FACTORS DETERMINING LONG-TERM OUTCOMES FOR ADULT SURVIVORS OF CHILDHOOD LOW-GRADE GLIOMA: A POPULATION-BASED STUDY

365. HG-53HYPERMUTATION AND NEOANTIGEN FORMATION PREDICT RESPONSE TO IMMUNE CHECKPOINT INHIBITION IN CHILDHOOD BIALLELIC MISMATCH REPAIR DEFICIENT GLIOBLASTOMA

366. LG-68THE GENETIC AND CLINICAL LANDSCAPE IN PEDIATRIC LOW GRADE GLIOMA; PRELIMINARY RESULTS FROM PLGG TASKFORCE

367. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

369. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

371. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

372. Invitation to a second round: tumour cells are non-uniform. The question is whether a distinct subpopulation of the cells drives tumour growth and generates cellular variation. To answer this, the data must be interpreted carefully

373. MicroRNAs and Parallel Stem Cell Lives

374. Subgroup-specific structural variation across 1,000 medulloblastoma genomes

375. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

376. Abstract B09: DNA polymerase mutations trigger rapid onset of ultra-hypermutant malignant brain tumors in children with biallelic mismatch repair deficiency

377. Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

378. Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma

379. BRAF Mutation and CDKN2A Deletion Define a Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma

380. Preclinical target validation using patient-derived cells

383. Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells

384. WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

385. Quiescent Sox2+ cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma

386. Immunolocalization of Fascin, an Actin‐Bundling Protein and Glial Fibrillary Acidic Protein in Human Astrocytoma Cells

387. Contributors

390. Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells

391. WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

392. Abstract A20: hTERT promoter hypermethylation is a cancer signature which predicts survival and response to targeted therapy in pediatric nervous system tumors

394. ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents

395. Integrative Genomic Analyses of Atypical Teratoid Rhabdoid Tumours (ATRTs)

396. Cell Surface Profiling Using High-Throughput Flow Cytometry: A Platform for Biomarker Discovery and Analysis of Cellular Heterogeneity

397. Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

399. Slow-Flow Spinal Epidural AVF with Venous Ectasias: Two Pediatric Case Reports

400. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

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