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A presente dissertação foi desenvolvida no Mestrado Profissional em Gestão e Avaliação da Educação Pública (PPGP) da Universidade Federal de Juiz de Fora. O caso de gestão discute a avaliação de desempenho dos professores da Secretaria Municipal de Educação de São Luís para fins de progressão na carreira, e teve por objetivo geral analisar os aspectos que devem ser revistos no procedimento atualmente adotado. Os objetivos específicos definidos na pesquisa foram: descrever o procedimento de avaliação de desempenho profissional dos professores da Rede Municipal de Educação de São Luís; analisar os desafios vivenciados durante a realização do procedimento avaliativo e propor um processo de avaliação de desempenho adequado às necessidades da Semed e favorável ao aprimoramento dos avaliados. No levantamento inicial de dados, foram evidenciados problemas no processo, como: não se dar de maneira contínua; a fragilidade do instrumento de avaliação, que não contempla a diversidade dos públicos alcançados; a avaliação ser feita unilateralmente pelos gestores, sem a participação dos avaliados; e a falta de oferecimento de feedback da avaliação. Com base na revisão da literatura, buscou-se as principais contribuições de autores que estudam a avaliação de desempenho, como as realizadas por Fernandes (2008); Zatti e Minhoto (2019); Avila e Stecca (2015); Dalmau e Benetti (2009); Odelius (2010) e Paradela e Costa (2019). Para atingir o objetivo proposto utilizou-se como metodologia a pesquisa com abordagem qualitativa, tendo como método, o estudo de caso. Como técnica de coleta de dados utilizou-se a pesquisa documental, aplicação de questionários, conversas e entrevistas com professores e gestores da Semed. Os resultados da pesquisa apontaram para as dificuldades vivenciadas no procedimento avaliativo que foram constatadas nas evidências, além da necessidade de implementação, pela Semed, de um sistema informatizado de avaliação de desempenho. Com base nos principais achados, foi possível propor ações que visam minimizar as dificuldades constatadas, dentre elas: a necessidade de readequação do instrumento avaliativo; a importância da realização da autoavaliação do professor e da instituição de uma comissão setorial para sua realização e, o oferecimento do feedback da avaliação aos professores. Nesse sentido, o Plano de Ação Educacional apresentado no capítulo 4, teve como objetivo propor ações exequíveis que favoreçam o aprimoramento do procedimento avaliativo, para que sua realização ocorra com o mínimo de entraves possíveis, e contribuir para o desenvolvimento profissional dos professores. This dissertation was developed in the Professional Master in Public Education Management and Evaluation (PPGP) at the Federal University of Juiz de Fora. The management case discusses the performance evaluation of teachers of the Municipal Department of Education of São Luís for career advancement purposes, and had the general objective of analyzing the aspects that should be reviewed in the procedure currently adopted. The specific objectives defined in the research were: to describe the procedure of professional performance evaluation of teachers of the Municipal Education Network of São Luís; to analyze the challenges experienced during the evaluation procedure and propose a process of performance evaluation appropriate to the needs of Semed and favorable to the improvement of the evaluated. In the initial data survey, problems in the process were evidenced, such as: not being continuous; the weakness of the evaluation instrument, which does not contemplate the diversity of the publics reached; the evaluation being done unilaterally by managers, without the participation of the evaluated; and the lack of feedback from the evaluation. Based on the literature review, it was sought the main contributions of authors who study performance evaluation, such as those made by Fernandes (2008); Zatti and Minhoto (2019); Avila and Stecca (2015); Dalmau and Benetti (2009); Odelius (2010) and Paradela and Costa (2019). To achieve the proposed objective it was used as methodology the research with qualitative approach, having as method, the case study. As a data collection technique it was used documentary research, questionnaires application, conversations and interviews with teachers and managers of Semed. The results of the research pointed to the difficulties experienced in the evaluation procedure that were verified in the evidence, in addition to the need for Semed to implement a computerized system of performance evaluation. Based on the main findings, it was possible to propose actions aimed at minimizing the difficulties found, among them: the need for readjustment of the evaluation instrument; the importance of conducting selfevaluation of the teacher and the establishment of a sectoral committee for its realization, and the provision of evaluation feedback to teachers. In this sense, the Educational Action Plan presented in chapter 4, aimed to propose feasible actions that favor the improvement of the evaluation procedure, so that its realization occurs with the least possible obstacles, and contribute to the professional development of teachers.

In the early years of the XXI Century, Bolivia a set of political, legal, economic and territorial transformations. At this time, Bolivia promoted a Constitutional Assembly in order to refound the State, putting it in the service of popular demands, mainly in the construction of a new integral State (LINERA, 2010), in decolonization, territorial integration, and nationalization of natural resources. In this sense, the Plurinational State of Bolivia was founded, as an answer to the territorial conflicts of the country. In this context, this work aims to verify the constitutional assurances promulgated by the Constitution of 2009 in the process of reaffirming the geographical horizontalities. This work is an interdisciplinary study in Law and Geography, whose methodology was bibliographic research and document analysis, especially regarding Milton Santos' geographical space category (2006) and the New Latin-American Constitutionalism, of Rubén Martínez Dalmau and Roberto Viciano Pastor (2012). En los primeros años del siglo XXI, se produjo en Bolivia un conjunto de transformaciones políticas, jurídicas, económicas y territoriales. En ese momento Bolivia promovió una asamblea constituyente con el objetivo de reformular el Estado, dejando al servicio de las demandas populares, principalmente en la construcción de un Estado Integral (LINERA, 2010b), de la descolonización, integración territorial y nacionalización de los recursos naturales. En ese sentido fue fundado el Estado Plurinacional de Bolivia, como una apuesta de solución a los conflictos territoriales del País. En razón de eso, este trabajo desea saber cuales son las garantías constitucionales promulgadas por la constitución de 2009 en el proceso de reafirmación de las horizontalidades geográficas. Se trata de un estudio interdisciplinar entre el derecho y la geografía cuya metodología fue la de pesquisa bibliográfica y análisis de documentos, estructurados a partir de la categoría de espacio geográfico de Milton Santos (2006) y de las premisas del Nuevo Constitucionalismo Latinoamericano, por sus diferentes exponentes, especialmente Rubén Martínez Dalmau y Roberto Viciano Pastor (2012). Nos primeiros anos do século XXI, ocorreu na Bolívia um conjunto de transformações políticas, jurídicas, econômicas e territoriais. Naquele momento a Bolívia promoveu uma assembleia constituinte com o intuito de refundar o Estado, colocando-o a serviço das demandas populares, principalmente na construção de um Estado integral (LINERAb, 2010), da descolonização, integração territorial e nacionalização dos recursos naturais. Nesse sentido foi fundado o Estado Plurinacional da Bolívia, como aposta de solução aos conflitos territoriais do país. Em face disso, este trabalho deseja saber quais são as garantias constitucionais promulgadas pela constituição de 2009 no processo de reafirmação das horizontalidades geográficas. Trata-se de um estudo interdisciplinar entre o Direito e a Geografia, cuja metodologia foi de pesquisa bibliográfica e análise de documentos, estruturados a partir da categoria de espaço geográfico de Milton Santos (2006) e das premissas do Novo Constitucionalismo Latino-Americano, por seus diversos expoentes, especialmente Rubén Martinez Dalmau e Roberto Viciano Pastor (2012).

Background: Evidence from clinical trials supports the neoadjuvant use of pertuzumab and trastuzumab with chemotherapy to improve the pathologic complete response (pCR) in early HER2+ breast cancer (BC), but information on the efficacy of this combination in the clinical practice setting is still limited. In order to widen its real-world data (RWD), we conducted an observational study to determine the pCR rate obtained in routine clinical practice. Methods: This was a multicenter, retrospective, observational study in patients (pts) with early HER2+ BC who received neoadjuvant therapy based on dual blockade with pertuzumab and trastuzumab. All data were retrospectively collected from pts medical charts. The primary study objective was the total pCR rate (ypT0/is ypN0). Secondary objectives included patient characteristics, neoadjuvant treatment patterns with the dual blockade, surgery types, breast pCR rate (ypT0is), and neoadjuvant safety profile. Results: Two hundred and forty-three evaluable pts treated in Spain between November 2013 and September 2017 were enrolled between October 2017 and February 2018 (median age [range] 51.7 [44.7-60.2] years; postmenopausal 47.7%; ECOG 0/1 88.9/10.6%; stage II/III tumors 54.3/28.7%; hormone receptor-positive 62.4%). The most common neoadjuvant chemotherapies used were taxanes+anthracyclines (n=180, 74.1%), platinum-based chemotherapies (n=35, 14.4%), and taxanes (n=27, 11.1%). Response rates (radiologic/clinical assessments) before surgery were: complete response 62.1% (n=151), partial response 33.3% (n=81), stable disease 4.1% (n=10), and non-evaluable 0.4% (n=1). Breast-conserving surgery (tumorectomy/lumpectomy and quadrantectomy) was performed in 57.8% (n=133) pts and not conserving (simple, radical and modified radical mastectomy) in 42.2% (n=97). The total pCR was 66.4% and breast pCR was 67.6%. Total pCR in the breast was achieved by 80.7% (n=67) hormone receptor-negative and 56.3% (n=76) hormone receptor-positive pts (statistically significant differences; p Conclusions: This is the first, to the best of our knowledge, multicenter observational study to determine the pCR rate obtained in routine clinical practice in Spain. Results obtained from it have been remarkable: neoadjuvant therapy based on dual blockade with pertuzumab and trastuzumab for HER2+ BC in the routine clinical practice setting enabled the achievement of total pCR rates over 66%, which are even higher than those obtained in previous clinical trials. In addition, this therapy has showed an acceptable safety profile, in line with previous assessments. Citation Format: Chacón JI, Saura C, Ciruelos E, Alonso JI, de la Morena P, Santisteban Eslava M, Gallegos I, de Luna A, Dalmau E, González-Santiago S. Real world evidence of neoadjuvant treatment based on dual blockade with pertuzumab plus trastuzumab for early HER2+ breast cancer: The NeoPETRA study [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P6-17-31.