181 results on '"Cho, Jaeyoung"'
Search Results
152. Surgical resection of nodular ground-glass opacities without percutaneous needle aspiration or biopsy
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Cho, Jaeyoung, primary, Ko, Sung-Jun, additional, Kim, Se Joong, additional, Lee, Yeon Joo, additional, Park, Jong Sun, additional, Cho, Young-Jae, additional, Yoon, Ho Il, additional, Cho, Sukki, additional, Kim, Kwhanmien, additional, Jheon, Sanghoon, additional, Lee, Jae Ho, additional, and Lee, Choon-Taek, additional
- Published
- 2014
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153. Liquefied Natural Gas Ship Route Planning Model Considering Market Trend Change
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Cho, Jaeyoung, primary, Lim, Gino J., primary, Biobaku, Taofeek, primary, Bora, Selim, primary, and Parsaei, Hamid, primary
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- 2014
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154. Reduction of Agricultural Non-point Pollution Source by Scenarios of Best Management Practices on Cropping System Alternatives of Main Upland Crop in Saemangeum Watershed
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Son, Jae Gwon, primary, Lee, Gyeong Ae, additional, Yoo, Dong Su, additional, and Cho, JaeYoung, additional
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- 2014
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155. ChemInform Abstract: Palladium‐Catalyzed Direct C‐3 Oxidative Alkenylation of Phosphachromones.
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Kang, Dongjin, primary, Cho, Jaeyoung, additional, and Lee, Phil Ho, additional
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- 2014
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156. A Stochastic Approach To Liquefied Natural Gas (lng) Ship Route Planning Model Under Weather Disruptions
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Cho, Jaeyoung, primary, Lim, Gino, additional, Biobaku, Taofeek, additional, Bora, Selim, additional, and Parsaei, Hamid, additional
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- 2014
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157. AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease
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Baek, In-Sun, primary, Kim, Tae-Kyung, additional, Seo, Ji-Seon, additional, Lee, Kang-Woo, additional, Lee, Young Ae, additional, Cho, Jaeyoung, additional, Gwag, Byoung Joo, additional, and Han, Pyung-Lim, additional
- Published
- 2013
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158. Palladium-catalyzed direct C-3 oxidative alkenylation of phosphachromones
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Kang, Dongjin, primary, Cho, Jaeyoung, additional, and Lee, Phil Ho, additional
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- 2013
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159. A 3.0-in. 308-ppi WVGA AMOLED with a top-emission white OLED and color filter
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Kim, Sangyeol, primary, Lee, Sunghun, additional, Kim, Mugyeom, additional, Song, Jeongbae, additional, Hwang, Eokchae, additional, Tamura, Shinichiro, additional, Kang, Sungkee, additional, Kim, Hyoseok, additional, Kim, Chiwoo, additional, Lee, Jinseok, additional, Kim, Jongmin, additional, Cho, Sungwoo, additional, Cho, Jaeyoung, additional, Suh, Min Chul, additional, and Kim, Hyedong, additional
- Published
- 2009
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160. 61.3: 3.0‐in. 308‐ppi WVGA AMOLED by Top‐Emitting White OLED with Color Filter
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Kim, SangYeol, primary, Kim, MuGyeom, additional, Lee, SungHun, additional, Song, JeongBae, additional, Tamura, Shinichiro, additional, Kang, SungKee, additional, Kim, JongMin, additional, Cho, SungWoo, additional, Cho, JaeYoung, additional, Suh, MinChul, additional, and Kim, HyeDong, additional
- Published
- 2008
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161. M1264 ND-07, a Compound Synthesized from Salicylate, Ameliorated Acute Pancreatitis in Several Animal Models; Candidate for Novel Therapeutics
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Lee, Jin Hwan, primary, An, Chun San, additional, Yoon, Bok-Seon, additional, Cho, Sung Ig, additional, Cho, Jaeyoung, additional, Sim, Heajin, additional, Gwag, Byoung Joo, additional, and Hahm, Ki-Baik, additional
- Published
- 2008
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162. Glial expression of the 90‐kDa heat shock protein (HSP90) and the 94‐kDa glucose‐regulated protein (GRP94) following an excitotoxic lesion in the mouse hippocampus
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Jeon, Gye Sun, primary, Park, Sang Wook, additional, Kim, Dong Woon, additional, Seo, Je Hoon, additional, Cho, Jaeyoung, additional, Lim, So Young, additional, Kim, Seong Deok, additional, and Cho, Sa Sun, additional
- Published
- 2004
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163. Lysophosphatidic acid stimulates CREB through mitogen- and stress-activated protein kinase-1
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Lee, Chang-Wook, primary, Nam, Ju-Suk, additional, Park, Yoon-Kyung, additional, Choi, Ho-Kyew, additional, Lee, Joo-Hyun, additional, Kim, Nam-Ho, additional, Cho, Jaeyoung, additional, Song, Dong-Keun, additional, Suh, Hong-Won, additional, Lee, Jongho, additional, Kim, Yung-Hi, additional, and Huh, Sung-Oh, additional
- Published
- 2003
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164. Increased expression of phosphatase and tensin homolog in reactive astrogliosis following intracerebroventricular kainic acid injection in mouse hippocampus
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Cho, Jaeyoung, primary, Lee, Sang-Hyun, additional, Seo, Je Hoon, additional, Kim, Hee-Sung, additional, Ahn, Jung-Gil, additional, Kim, Sung-Soo, additional, Yim, Sung-Vin, additional, Song, Dong-Keun, additional, and Cho, Sa Sun, additional
- Published
- 2002
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165. Cloning and characterization of a divergent α-tubulin that is expressed specifically in dividing amebae of Naegleria gruberi
- Author
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Chung, Sunglan, primary, Cho, Jaeyoung, additional, Cheon, HyeonJoo, additional, Paik, Soonyoung, additional, and Lee, JooHun, additional
- Published
- 2002
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166. Loss of Developing Cholinergic Basal Forebrain Neurons Following Excitotoxic Lesions of the Hippocampus: Rescue by Neurotrophins
- Author
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Burke, Melanie A., primary, Mobley, William C., additional, Cho, Jaeyoung, additional, Wiegand, Stanley J., additional, Lindsay, Ronald M., additional, Mufson, Elliott J., additional, and Kordower, Jeffrey H., additional
- Published
- 1994
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167. Obstructive Sleep Apnea Screening and Effects of Surgery in Acromegaly: A Prospective Study.
- Author
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Cho J, Kim JH, Kim YH, and Lee J
- Subjects
- Humans, Male, Female, Middle Aged, Prospective Studies, Adult, Polysomnography methods, Endoscopy methods, Treatment Outcome, Mass Screening methods, Sleep Apnea, Obstructive surgery, Sleep Apnea, Obstructive blood, Sleep Apnea, Obstructive complications, Sleep Apnea, Obstructive diagnosis, Acromegaly surgery, Acromegaly blood, Acromegaly complications, Insulin-Like Growth Factor I analysis, Insulin-Like Growth Factor I metabolism
- Abstract
Backgruound: To identify a screening tool for obstructive sleep apnea (OSA) and evaluate the effects of endoscopic transsphenoidal surgery on improving OSA in patients with acromegaly., Methods: We prospectively enrolled adults with acromegaly scheduled for endoscopic transsphenoidal surgery. All measurements were conducted when participants were admitted for a baseline work-up for acromegaly before surgery and surveillance approximately 3 to 6 months after surgery. Respiratory event index (REI) was used as a surrogate for apnea-hypopnea index (Trial Registration: NCT03526016)., Results: Of the 35 patients with acromegaly (median age, 47 years; 40% men; median body mass index, 24.4 kg/m2), 24 (68.6%) had OSA (REI ≥5/hour), 15 (42.9%) had moderate-to-severe OSA (REI ≥15/hour). At baseline, serum insulin-like growth factor 1 (IGF-1) levels were positively correlated with the REI (ρ=0.53, P=0.001). The sensitivity and negative predictive value of a Snoring, Tiredness, Observed apnea, high blood Pressure-Body mass index, age, Neck circumference, and Gender (STOP-Bang) score ≥ 3 were 93.3% and 87.5%, respectively, detecting moderate-to-severe OSA. Biochemical acromegaly remission was achieved in 32 (91.4%) patients. The median difference in the REI was -9.5/hour (95% confidence interval, -13.3 to -5.3). Half of the 24 patients diagnosed with OSA preoperatively had REI <5/hour postoperatively. In a linear mixed-effects model, changes in the REI across surgery were related to changes in IGF-1 levels., Conclusion: The STOP-Bang questionnaire is a reliable tool for OSA among patients with acromegaly. Improvement in OSA severity after surgery is related to decreased IGF-1 levels.
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- 2024
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168. The Brain Tumor Segmentation - Metastases (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI.
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Moawad AW, Janas A, Baid U, Ramakrishnan D, Saluja R, Ashraf N, Jekel L, Amiruddin R, Adewole M, Albrecht J, Anazodo U, Aneja S, Anwar SM, Bergquist T, Calabrese E, Chiang V, Chung V, Conte GMM, Dako F, Eddy J, Ezhov I, Familiar A, Farahani K, Iglesias JE, Jiang Z, Johanson E, Kazerooni AF, Kofler F, Krantchev K, LaBella D, Van Leemput K, Li HB, Linguraru MG, Link KE, Liu X, Maleki N, Meier Z, Menze BH, Moy H, Osenberg K, Piraud M, Reitman Z, Shinohara RT, Tahon NH, Nada A, Velichko YS, Wang C, Wiestler B, Wiggins W, Shafique U, Willms K, Avesta A, Bousabarah K, Chakrabarty S, Gennaro N, Holler W, Kaur M, LaMontagne P, Lin M, Lost J, Marcus DS, Maresca R, Merkaj S, Nada A, Pedersen GC, von Reppert M, Sotiras A, Teytelboym O, Tillmans N, Westerhoff M, Youssef A, Godfrey D, Floyd S, Rauschecker A, Villanueva-Meyer J, Pflüger I, Cho J, Bendszus M, Brugnara G, Cramer J, Perez-Carillo GJG, Johnson DR, Kam A, Kwan BYM, Lai L, Lall NU, Memon F, Patro SN, Petrovic B, So TY, Thompson G, Wu L, Schrickel EB, Bansal A, Barkhof F, Besada C, Chu S, Druzgal J, Dusoi A, Farage L, Feltrin F, Fong A, Fung SH, Gray RI, Ikuta I, Iv M, Postma AA, Mahajan A, Joyner D, Krumpelman C, Letourneau-Guillon L, Lincoln CM, Maros ME, Miller E, Morón F, Nimchinsky EA, Ozsarlak O, Patel U, Rohatgi S, Saha A, Sayah A, Schwartz ED, Shih R, Shiroishi MS, Small JE, Tanwar M, Valerie J, Weinberg BD, White ML, Young R, Zohrabian VM, Azizova A, Brüßeler MMT, Fehringer P, Ghonim M, Ghonim M, Gkampenis A, Okar A, Pasquini L, Sharifi Y, Singh G, Sollmann N, Soumala T, Taherzadeh M, Yordanov N, Vollmuth P, Foltyn-Dumitru M, Malhotra A, Abayazeed AH, Dellepiane F, Lohmann P, Pérez-García VM, Elhalawani H, Al-Rubaiey S, Armindo RD, Ashraf K, Asla MM, Badawy M, Bisschop J, Lomer NB, Bukatz J, Chen J, Cimflova P, Corr F, Crawley A, Deptula L, Elakhdar T, Shawali IH, Faghani S, Frick A, Gulati V, Haider MA, Hierro F, Dahl RH, Jacobs SM, Hsieh KJ, Kandemirli SG, Kersting K, Kida L, Kollia S, Koukoulithras I, Li X, Abouelatta A, Mansour A, Maria-Zamfirescu RC, Marsiglia M, Mateo-Camacho YS, McArthur M, McDonnell O, McHugh M, Moassefi M, Morsi SM, Muntenu A, Nandolia KK, Naqvi SR, Nikanpour Y, Alnoury M, Nouh AMA, Pappafava F, Patel MD, Petrucci S, Rawie E, Raymond S, Roohani B, Sabouhi S, Sanchez-Garcia LM, Shaked Z, Suthar PP, Altes T, Isufi E, Dhermesh Y, Gass J, Thacker J, Tarabishy AR, Turner B, Vacca S, Vilanilam GK, Warren D, Weiss D, Willms K, Worede F, Yousry S, Lerebo W, Aristizabal A, Karargyris A, Kassem H, Pati S, Sheller M, Bakas S, Rudie JD, and Aboian M
- Abstract
The translation of AI-generated brain metastases (BM) segmentation into clinical practice relies heavily on diverse, high-quality annotated medical imaging datasets. The BraTS-METS 2023 challenge has gained momentum for testing and benchmarking algorithms using rigorously annotated internationally compiled real-world datasets. This study presents the results of the segmentation challenge and characterizes the challenging cases that impacted the performance of the winning algorithms. Untreated brain metastases on standard anatomic MRI sequences (T1, T2, FLAIR, T1PG) from eight contributed international datasets were annotated in stepwise method: published UNET algorithms, student, neuroradiologist, final approver neuroradiologist. Segmentations were ranked based on lesion-wise Dice and Hausdorff distance (HD95) scores. False positives (FP) and false negatives (FN) were rigorously penalized, receiving a score of 0 for Dice and a fixed penalty of 374 for HD95. The mean scores for the teams were calculated. Eight datasets comprising 1303 studies were annotated, with 402 studies (3076 lesions) released on Synapse as publicly available datasets to challenge competitors. Additionally, 31 studies (139 lesions) were held out for validation, and 59 studies (218 lesions) were used for testing. Segmentation accuracy was measured as rank across subjects, with the winning team achieving a LesionWise mean score of 7.9. The Dice score for the winning team was 0.65 ± 0.25. Common errors among the leading teams included false negatives for small lesions and misregistration of masks in space. The Dice scores and lesion detection rates of all algorithms diminished with decreasing tumor size, particularly for tumors smaller than 100 mm3. In conclusion, algorithms for BM segmentation require further refinement to balance high sensitivity in lesion detection with the minimization of false positives and negatives. The BraTS-METS 2023 challenge successfully curated well-annotated, diverse datasets and identified common errors, facilitating the translation of BM segmentation across varied clinical environments and providing personalized volumetric reports to patients undergoing BM treatment., Competing Interests: Conflicts of Interest No conflicts of interest to disclose.
- Published
- 2024
169. Differential Diagnosis of Pleural Effusion Using Machine Learning.
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Kim NY, Jang B, Gu KM, Park YS, Kim YG, and Cho J
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- Adult, Humans, Diagnosis, Differential, Retrospective Studies, Exudates and Transudates, Machine Learning, Adenosine Deaminase metabolism, Pleural Effusion diagnosis, Pleural Effusion etiology
- Abstract
Rationale: Differential diagnosis of pleural effusion is challenging in clinical practice. Objectives: We aimed to develop a machine learning model to classify the five common causes of pleural effusions. Methods: This retrospective study collected 49 features from clinical information, blood, and pleural fluid of adult patients who underwent diagnostic thoracentesis between October 2013 and December 2018. Pleural effusions were classified into the following five categories: transudative, malignant, parapneumonic, tuberculous, and other. The performance of five different classifiers, including multinomial logistic regression, support vector machine, random forest, extreme gradient boosting, and light gradient boosting machine (LGB), was evaluated in terms of accuracy and area under the receiver operating characteristic curve through fivefold cross-validation. Hybrid feature selection was applied to determine the most relevant features for classifying pleural effusion. Results: We analyzed 2,253 patients (training set, n = 1,459; validation set, n = 365; extra-validation set, n = 429) and found that the LGB model achieved the best performance in both validation and extra-validation sets. After feature selection, the accuracy of the LGB model with the selected 18 features was equivalent to that with all 49 features (mean ± standard deviation): 0.818 ± 0.012 and 0.777 ± 0.007 in the validation and extra-validation sets, respectively. The model's mean area under the receiver operating characteristic curve was as high as 0.930 ± 0.042 and 0.916 ± 0.044 in the validation and extra-validation sets, respectively. In our model, pleural lactate dehydrogenase, protein, and adenosine deaminase levels were the most important factors for classifying pleural effusions. Conclusions: Our LGB model showed satisfactory performance for differential diagnosis of the common causes of pleural effusions. This model could provide clinicians with valuable information regarding the major differential diagnoses of pleural diseases.
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- 2024
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170. Effect of the human papillomavirus vaccine on the risk of genital warts: a nationwide cohort study of Korean adolescent girls.
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Cho J, Kim EM, Kim J, Shin JY, Kim EH, Park JH, Kwon SL, Kwon GY, Shin SA, and Kim J
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- Humans, Female, Adolescent, Republic of Korea epidemiology, Retrospective Studies, Child, Incidence, Cohort Studies, Papillomavirus Infections prevention & control, Papillomavirus Infections epidemiology, Immunization Programs, Papillomavirus Vaccines administration & dosage, Condylomata Acuminata prevention & control, Condylomata Acuminata epidemiology
- Abstract
Objectives: The purpose of this study was to assess the effectiveness of human papillomavirus (HPV) vaccination administered to adolescent girls through Korea's National Immunization Program., Methods: This retrospective cohort study included patients who were 12-13 years old, whether vaccinated or unvaccinated, between July 2016 and December 2017. The incidence of genital warts (GWs) was monitored through 2021. Time-stratified hazard ratios (HRs) were estimated, adjusting for birth year, socioeconomic status, and the level of urbanization of the region, and were presented with 95% confidence intervals (CIs). Data were sourced from the Immunization Registry Integration System, linked with the National Health Information Database., Results: The study included 332,062 adolescent girls, with an average follow-up period of approximately 4.6 years. Except for the first year, the HRs for the vaccinated group were lower than those for the unvaccinated group. The HRs for specific cut-off years were as follows: year 2, 0.62 (95% CI, 0.31 to 1.13); year 3, 0.58 (95% CI, 0.35 to 0.96); and year 4 and beyond, 0.39 (95% CI, 0.28 to 0.52)., Conclusions: Our findings indicate that HPV vaccination was associated with a reduction in the risk of GWs among adolescent girls. Notably, this reduction became significant as the incidence of GWs increased with age.
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- 2024
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171. Bimolecular Peroxy Radical (RO 2 ) Reactions and Their Relevance in Radical Initiated Oxidation of Hydrocarbons.
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Cho J, Mulvihill CR, Klippenstein SJ, and Sivaramakrishnan R
- Abstract
The kinetics of peroxy radical (RO
2 ) reactions have been of long-standing interest in atmospheric and combustion chemistry. Nevertheless, the lack of kinetic studies at higher temperatures for their reactions with other radicals such as OH has precluded the inclusion of this class of reactions in detailed kinetics models developed for combustion applications. In this work, guided by the limited room-temperature experimental studies on selected alkyl-peroxy radicals and literature theoretical kinetics on the prototypical CH3 O2 + OH system, we have performed parametric studies on the effect of uncertainties in the rate coefficients and branching ratios to potential product channels for RO2 + OH reactions at higher temperatures. Literature kinetics models were used to simulate autoignition delays, laminar flame speeds, and speciation profiles in flow and stirred reactors for a variety of common combustion-relevant fuels. Inclusion of RO2 + OH reactions was found to retard autoignition in fuel-lean (φ = 0.5) mixtures of ethane and dimethyl ether in air. The observed effects were noticeably more pronounced in ozone-enriched combustion of ethane and dimethyl ether. The simulations also examined the influence of ozone doping levels, pressures, and equivalence ratios for both ethane and dimethyl ether oxidation. Sensitivity and flux analyses revealed that the RO2 + OH reaction is a significant sink of RO2 radicals at the early stage of autoignition, affecting fuel oxidation through RO2 ↔ QOOH, RO2 ↔ alkene + HO2 , or RO2 + HO2 ↔ ROOH + O2 . Additionally, the kinetic stability of the trioxide formed from RO2 + OH reactions was investigated using master equation analyses. Last, we discuss other bimolecular reactions that are missing in literature kinetics models but are relevant to hydrocarbon oxidation initiated by external radical sources (plasma-enhanced, ozone-enriched combustion, etc.). The present simulations provide a strong motivation for better characterizing the bimolecular kinetics of peroxy radicals.- Published
- 2023
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172. Genome-wide association study of non-tuberculous mycobacterial pulmonary disease.
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Cho J, Park K, Choi SM, Lee J, Lee CH, Lee JK, Heo EY, Kim DK, Lee YJ, Park JS, Cho YJ, Yoon HI, Lee JH, Lee CT, Kim N, Choi KY, Lee KH, Sung J, Won S, and Yim JJ
- Subjects
- Alleles, Case-Control Studies, Female, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Republic of Korea, Apoptosis Regulatory Proteins genetics, Chromosomes, Human, Pair 7, Genetic Predisposition to Disease, Genome-Wide Association Study, Mycobacterium Infections, Nontuberculous genetics, Protein Serine-Threonine Kinases genetics
- Abstract
Background: The prevalence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) is increasing in South Korea and many parts of the world. However, the genetic factors underlying susceptibility to this disease remain elusive., Methods: To identify genetic variants in patients with NTM-PD, we performed a genome-wide association study with 403 Korean patients with NTM-PD and 306 healthy controls from the Healthy Twin Study, Korea cohort. Candidate variants from the discovery cohort were subsequently validated in an independent cohort. The Genotype-Tissue Expression (GTEx) database was used to identify expression quantitative trait loci (eQTL) and to conduct Mendelian randomisation (MR)., Results: We identified a putatively significant locus on chromosome 7p13, rs849177 (OR, 2.34; 95% CI, 1.71 to 3.21; p=1.36×10
-7 ), as the candidate genetic variant associated with NTM-PD susceptibility. Its association was subsequently replicated and the combined p value was 4.92×10-8 . The eQTL analysis showed that a risk allele at rs849177 was associated with lower expression levels of STK17A , a proapoptotic gene. In the MR analysis, a causal effect of STK17A on NTM-PD development was identified (β, -4.627; 95% CI, -8.768 to -0.486; p=0.029)., Conclusions: The 7p13 genetic variant might be associated with susceptibility to NTM-PD in the Korean population by altering the expression level of STK17A ., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.)- Published
- 2021
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173. Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study.
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Cho J, Lee CH, Kim DK, Hwang HG, Kim YI, Choi HS, Park JW, Yoo KH, Jung KS, and Lee SD
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- Forced Expiratory Volume, Humans, Longitudinal Studies, Propensity Score, Prospective Studies, Bronchodilator Agents therapeutic use, Pulmonary Disease, Chronic Obstructive diagnosis, Pulmonary Disease, Chronic Obstructive drug therapy, Pulmonary Disease, Chronic Obstructive epidemiology
- Abstract
Background/aims: Despite increasing awareness of the burden of chronic obstructive pulmonary disease (COPD) in women, knowledge regarding gender differences in COPD outcomes is limited. Therefore, we aimed to evaluate whether COPD outcomes, including exacerbations, lung function, and symptoms differ by gender., Methods: We recruited patients with COPD from two Korean multicenter prospective cohorts. After propensity score matching, the main outcome, the incidence of moderate or severe exacerbations was analyzed using a negative binomial regression model. We also assessed changes in lung function and symptom scores including the St. George's respiratory questionnaire for COPD (SGRQ-C), COPD assessment test (CAT), and the modified Medical Research Council (mMRC) dyspnea score., Results: After propensity score matching, 74 women and 74 men with COPD were included. The incidence rates of exacerbations in women and men were not significantly different (incidence rate ratio, 1.49; 95% confidence interval [CI], 0.88 to 2.54). There was no significant difference in the incidence rates adjusted for medication possession ratios of long-acting muscarinic antagonists, long-acting β-agonists, and inhaled corticosteroids during the follow-up period (incidence rate ratio, 1.47; 95% CI, 0.86 to 2.52). Rates of decline in post-bronchodilator forced expiratory volume in 1 second and forced vital capacity did not differ between women and men during 48 months of follow-up. The changes in scores on the SGRQ-C, CAT, and mMRC Questionnaire in women were also similar to those in men., Conclusion: We observed no gender differences in the rate of exacerbations of COPD in a prospective longitudinal study. Further studies are needed to confirm these findings in the general COPD population.
- Published
- 2020
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174. Correction of Severe Dermatochalasis in Asians Using an Extended Infrabrow Excision.
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Burm JS, Hwang J, and Cho J
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- Aged, Female, Humans, Male, Middle Aged, Republic of Korea, Blepharoplasty methods, Skin Aging, Skin Diseases surgery
- Published
- 2020
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175. Mortality risk and causes of death in patients with non-cystic fibrosis bronchiectasis.
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Sin S, Yun SY, Kim JM, Park CM, Cho J, Choi SM, Lee J, Park YS, Lee SM, Yoo CG, Kim YW, Han SK, and Lee CH
- Subjects
- Adult, Bronchiectasis pathology, Case-Control Studies, Cystic Fibrosis, Female, Fibrosis mortality, Fibrosis pathology, Hospitals, University, Humans, Lung Neoplasms diagnostic imaging, Lung Neoplasms pathology, Male, Middle Aged, Proportional Hazards Models, Radiography, Thoracic methods, Reference Values, Republic of Korea, Respiratory Function Tests, Retrospective Studies, Risk Assessment, Severity of Illness Index, Survival Analysis, Tomography, X-Ray Computed methods, Young Adult, Bronchiectasis diagnostic imaging, Bronchiectasis mortality, Cause of Death, Lung Neoplasms mortality
- Abstract
Background: All-cause mortality risk and causes of death in bronchiectasis patients have not been fully investigated. The aim of this study was to compare the mortality risk and causes of death between individuals with bronchiectasis and those without bronchiectasis., Methods: Patients with or without bronchiectasis determined based on chest computed tomography (CT) at one centre between 2005 and 2016 were enrolled. Among the patients without bronchiectasis, a control group was selected after applying additional exclusion criteria. We compared the mortality risk and causes of death between the bronchiectasis and control groups without lung disease. Subgroup analyses were also performed according to identification of Pseudomonas or non-tuberculous mycobacteria, airflow limitation, and smoking status., Results: Of the total 217,702 patients who underwent chest CT, 18,134 bronchiectasis patients and 90,313 non-bronchiectasis patients were included. The all-cause mortality rate in the bronchiectasis group was 1608.8 per 100,000 person-years (95% confidence interval (CI), 1531.5-1690.0), which was higher than that in the control group (133.5 per 100,000 person-years; 95% CI, 124.1-143.8; P < 0.001). The bronchiectasis group had higher all-cause (adjusted hazard ratio (aHR), 1.26; 95% CI, 1.09-1.47), respiratory (aHR, 3.49; 95% CI, 2.21-5.51), and lung cancer-related (aHR, 3.48; 95% CI, 2.33-5.22) mortality risks than the control group. In subgroup analysis, patients with airflow limitation and ever smokers showed higher all-cause mortality risk among bronchiectasis patients. Therefore, we observed significant interrelation between bronchiectasis and smoking, concerning the risks of all-cause mortality (P for multiplicative interaction, 0.030, RERI, 0.432; 95% CI, 0.097-0.769) and lung cancer-related mortality (RERI, 8.68; 95% CI, 1.631-15.736)., Conclusion: Individuals with bronchiectasis had a higher risk of all-cause, respiratory, and lung cancer-related mortality compared to control group. The risk of all-cause mortality was more prominent in those with airflow limitation and in ever smokers.
- Published
- 2019
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176. Role of ethambutol and rifampicin in the treatment of Mycobacterium avium complex pulmonary disease.
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Kim HJ, Lee JS, Kwak N, Cho J, Lee CH, Han SK, and Yim JJ
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- Adult, Aged, Antibiotics, Antitubercular therapeutic use, Antitubercular Agents therapeutic use, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Lung Diseases diagnosis, Lung Diseases microbiology, Male, Middle Aged, Mycobacterium avium-intracellulare Infection diagnosis, Mycobacterium avium-intracellulare Infection microbiology, Radiography, Thoracic, Retrospective Studies, Time Factors, Treatment Outcome, Young Adult, Ethambutol therapeutic use, Lung Diseases drug therapy, Mycobacterium avium Complex isolation & purification, Mycobacterium avium-intracellulare Infection drug therapy, Rifampin therapeutic use
- Abstract
Background: A three-drug regimen (macrolide, ethambutol, and rifampicin) is recommended for the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD). Although macrolide has proven efficacy, the role of ethambutol and rifampicin in patients without acquired immune deficiency syndrome is not proven with clinical studies. We aimed to clarify the roles of ethambutol and rifampicin in the treatment of MAC-PD., Methods: Patients treated for MAC-PD between March 1st, 2009 and October 31st, 2018 were reviewed retrospectively. Rates of culture conversion, microbiological cure, treatment failure, and recurrence were compared according to the maintenance (≥6 months) of ethambutol or rifampicin with macrolide., Results: Among the 237 patients, 122 (51.5%) maintained ethambutol and rifampicin with macrolide, 58 (24.5%) maintained ethambutol and macrolide, 32 (13.5%) maintained rifampicin and macrolide, and 25 (10.6%) maintained macrolide only. Culture conversion was reached for 190/237 (80.2%) patients and microbiological cure was achieved for 129/177 (72.9%) who completed the treatment. Treatment failure despite ≥12 months of treatment was observed in 66/204 (32.4%), and recurrence was identified in 16/129 (12.4%) who achieved microbiological cure. Compared with maintenance of macrolide only, maintenance of ethambutol, rifampicin or both with macrolide were associated with higher odds of culture conversion [odds ratio (OR), 95% confidence interval (CI): 18.06, 3.67-88.92; 15.82, 2.38-105.33; and 17.12, 3.93-74.60, respectively]. Higher odds of microbiological cure were associated with maintenance of both ethambutol and rifampicin with macrolide (OR, 95% CI: 5.74, 1.54-21.42) and macrolide and ethambutol (OR, 95% CI: 5.12, 1.72-15.24) but not macrolide and rifampicin. Maintenance of both ethambutol and rifampicin with macrolide was associated with lower odds of treatment failure (OR, 95% CI: 0.09, 0.01-0.53) compared with macrolide only, while maintenance of one of these with macrolide was not. Maintenance of both ethambutol and rifampicin or one of these with macrolide did not decrease the probability of recurrence when compared with macrolide only., Conclusions: Maintenance (≥6 months) of ethambutol and rifampicin with macrolide was associated with the most favorable treatment outcomes among patients with MAC-PD. Given the association between ongoing ethambutol use and microbiological cure, clinicians should maintain ethambutol unless definite adverse events develop.
- Published
- 2019
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177. Risk of acute exacerbations in chronic obstructive pulmonary disease associated with biomass smoke compared with tobacco smoke.
- Author
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Cho J, Lee CH, Hwang SS, Kim KU, Lee SH, Park HY, Park SJ, Min KH, Oh YM, Yoo KH, and Jung KS
- Subjects
- Aged, Disease Progression, Environmental Exposure, Female, Forced Expiratory Volume, Humans, Linear Models, Male, Middle Aged, Prospective Studies, Pulmonary Disease, Chronic Obstructive epidemiology, Republic of Korea epidemiology, Smoking epidemiology, Biomass, Pulmonary Disease, Chronic Obstructive etiology, Smoke adverse effects, Smoking adverse effects, Nicotiana adverse effects
- Abstract
Background: Risk of exacerbations in chronic obstructive pulmonary disease (COPD) associated with biomass smoke has not been well addressed, although biomass smoke is similar in composition to tobacco smoke., Methods: To investigate whether the risk of exacerbations in COPD associated with biomass smoke differs from that in COPD associated with tobacco smoke, we recruited patients with COPD from two Korean multicenter prospective cohorts. In a multiple linear regression model, the standardized regression coefficient (β) of biomass smoke exposure ≥25 years was most similar to that (β
' ) of tobacco smoke exposure ≥10 pack-years (β = - 0.13 and β' = - 0.14). We grouped patients with COPD into four categories based on the above cut-offs: Less Tobacco-Less Biomass, Less Tobacco-More Biomass, More Tobacco-Less Biomass, and More Tobacco-More Biomass. The main outcome was the incidence of moderate or severe exacerbations., Results: Among 1033 patients with COPD, 107 were included in Less Tobacco-Less Biomass (mean age: 67 years, men: 67%), 40 in Less Tobacco-More Biomass (mean age: 70 years, men: 35%), 631 in More Tobacco-Less Biomass (mean age: 68 years, men: 98%), and 255 in More Tobacco-More Biomass (mean age: 69 years, men: 97%). The incidence rates of exacerbations were not significantly different between Less Tobacco-More Biomass and More Tobacco-Less Biomass (adjusted incidence rate ratio, 1.03; 95% confidence interval, 0.56-1.89; P = 0.921). No interaction between sex and tobacco and biomass smoke was observed. When propensity score matching with available covariates including age and sex was applied, a similar result was observed., Conclusions: Patients with COPD associated with biomass smoke and those with COPD associated with tobacco smoke had a similar risk of exacerbations. This suggests that patients with COPD associated with biomass smoke should be treated actively.- Published
- 2019
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178. Anatomical distributional defects in mutant genes associated with dominant intermediate Charcot-Marie-Tooth disease type C in an adenovirus-mediated mouse model.
- Author
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Lee S, Panthi S, Jo HW, Cho J, Kim MS, Jeong NY, Song IO, Jung J, and Huh Y
- Abstract
Dominant intermediate Charcot-Marie-Tooth disease type C (DI-CMTC) is a dominantly inherited neuropathy that has been classified primarily based on motor conduction velocity tests but is now known to involve axonal and demyelination features. DI-CMTC is linked to tyrosyl-tRNA synthetase (YARS)-associated neuropathies, which are caused by E196K and G41R missense mutations and a single de novo deletion (153-156delVKQV). It is well-established that these YARS mutations induce neuronal dysfunction, morphological symptoms involving axonal degeneration, and impaired motor performance. The present study is the first to describe a novel mouse model of YARS-mutation-induced neuropathy involving a neuron-specific promoter with a deleted mitochondrial targeting sequence that inhibits the expression of YARS protein in the mitochondria. An adenovirus vector system and in vivo techniques were utilized to express YARS fusion proteins with a Flag-tag in the spinal cord, peripheral axons, and dorsal root ganglia. Following transfection of YARS-expressing viruses, the distributions of wild-type (WT) YARS and E196K mutant proteins were compared in all expressed regions; G41R was not expressed. The proportion of Flag/green fluorescent protein (GFP) double-positive signaling in the E196K mutant-type mice did not significantly differ from that of WT mice in dorsal root ganglion neurons. All adenovirus genes, and even the empty vector without the YARS gene, exhibited GFP-positive signaling in the ventral horn of the spinal cord because GFP in an adenovirus vector is driven by a cytomegalovirus promoter. The present study demonstrated that anatomical differences in tissue can lead to dissimilar expressions of YARS genes. Thus, use of this novel animal model will provide data regarding distributional defects between mutant and WT genes in neurons, the DI-CMTC phenotype, and potential treatment approaches for this disease., Competing Interests: Conflicts of interest: None declared.
- Published
- 2017
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179. Progression and Treatment Outcomes of Lung Disease Caused by Mycobacterium abscessus and Mycobacterium massiliense.
- Author
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Park J, Cho J, Lee CH, Han SK, and Yim JJ
- Subjects
- Aged, Azithromycin pharmacology, Azithromycin therapeutic use, Clarithromycin therapeutic use, Disease Progression, Female, Humans, Lung Diseases diagnosis, Lung Diseases microbiology, Male, Microbial Sensitivity Tests, Middle Aged, Mycobacterium Infections, Nontuberculous diagnosis, Nontuberculous Mycobacteria isolation & purification, Retrospective Studies, Risk Factors, Sputum microbiology, Treatment Outcome, Anti-Bacterial Agents therapeutic use, Clarithromycin pharmacology, Lung Diseases drug therapy, Mycobacterium Infections, Nontuberculous drug therapy, Mycobacterium Infections, Nontuberculous microbiology, Nontuberculous Mycobacteria drug effects
- Abstract
Background: Mycobacterium abscessus and Mycobacterium massiliense are grouped as the Mycobacterium abscessus complex. The aim of this study was to elucidate the differences between M. abscessus and M. massiliense lung diseases in terms of progression rate, treatment outcome, and the predictors thereof., Methods: Between 1 January 2006 and 30 June 2015, 56 patients and 54 patients were diagnosed with M. abscessus and M. massiliense lung diseases, respectively. The time to progression requiring treatment and treatment outcomes were compared between the 2 groups of patients, and predictors of progression and sustained culture conversion with treatment were analyzed. In addition, mediation analysis was performed to evaluate the effect of susceptibility to clarithromycin on treatment outcomes., Results: During follow-up, 21 of 56 patients with M. abscessus lung diseases and 21 of 54 patients with M. massiliense lung diseases progressed, requiring treatment. No difference was detected in the time to progression between the 2 patient groups. Lower body mass index, bilateral lung involvement, and fibrocavitary-type disease were identified as predictors of disease progression. Among the patients who began treatment, infection with M. massiliense rather than M. abscessus and the use of azithromycin rather than clarithromycin were associated with sustained culture conversion. The difference in treatment outcomes was partly mediated by the organism's susceptibility to clarithromycin., Conclusions: Progression rates were similar but treatment outcomes differed significantly between patients with lung disease caused by M. abscessus and M. massiliense. This difference in treatment outcomes was partly explained by the susceptibility of these organisms to clarithromycin., (© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.)
- Published
- 2017
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180. Empyema necessitatis due to Aspergillus fumigatus.
- Author
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Lee HW, Kim YW, Cho J, and Lee CH
- Subjects
- Antifungal Agents administration & dosage, Aspergillosis complications, Aspergillosis microbiology, Aspergillosis therapy, Debridement, Diagnosis, Differential, Empyema complications, Empyema microbiology, Empyema therapy, Exanthema etiology, Female, Humans, Middle Aged, Thorax, Aspergillosis diagnosis, Aspergillus fumigatus isolation & purification, Empyema diagnosis
- Abstract
We present an extremely rare case of empyema necessitatis secondary to Aspergillus fumigatus infection. A 58-year-old woman presented to our hospital with a painful skin rash on the right thorax. Three fistulas communicating with the pleural space were found. Since she did not show a clinical improvement despite antituberculous and antibacterial treatment, we looked for other causes. Pleural fungus culture showed A. fumigatus and chest wall biopsy revealed numerous fungal hyphae. Treatment with necrotic tissue debridement and antifungal agents was successful., (2014 BMJ Publishing Group Ltd.)
- Published
- 2014
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181. Cloning and characterization of a divergent alpha-tubulin that is expressed specifically in dividing amebae of Naegleria gruberi.
- Author
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Chung S, Cho J, Cheon H, Paik S, and Lee J
- Subjects
- Amino Acid Sequence, Animals, Antibodies immunology, Antibody Specificity, Base Sequence, Cell Differentiation genetics, Cell Division genetics, Cloning, Molecular, DNA, Protozoan chemistry, DNA, Protozoan genetics, Gene Expression, Genetic Variation, Mitosis genetics, Molecular Sequence Data, Phylogeny, Protein Isoforms genetics, Protein Isoforms immunology, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Tubulin immunology, Naegleria genetics, Tubulin genetics
- Abstract
A novel alpha-tubulin gene (alpha6) was cloned from a genomic library of Naegleria gruberi strain NB-1 and characterized. The open reading frame of alpha6 contained 1359 nucleotides encoding a protein of 452 amino acids (aa) with a calculated molecular weight of 50.5 kDa. The nucleotide sequence of the open reading frame of alpha6 showed considerable divergence (68.4% identity) when compared with previously cloned N. gruberi alpha-tubulin genes, which share about 97% identity in DNA sequences. The deduced aa sequence of alpha6-tubulin was 61.9% identical to that of alpha13-tubulin, which was cloned from the same strain, and showed similar identities to those of alpha-tubulins from other species (54 approximately 62%). These data showed that alpha6-tubulin is one of the most divergent alpha-tubulins so far known. Alpha6-tubulin was found to be expressed in actively growing cells and repressed quickly when these cells were induced to differentiate. Immunostaining with an antibody against alpha6-tubulin showed that alpha6-tubulin is present in the nuclei and mitotic spindle-fibers but absent in flagellar axonemes or cytoskeletal microtubules. These data finally established the presence of an alpha-tubulin that is specifically utilized for spindle-fiber microtubules and distinct from the flagellar axonemal alpha-tubulins in N. gruberi, hence confirmed the multi-tubulin hypothesis in this organism.
- Published
- 2002
- Full Text
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