346 results on '"Barry, Andrew"'
Search Results
302. The science of science : programmes of British space research
- Author
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Barry, Andrew Michael
- Subjects
- 629.4, Space technology, general
- Published
- 1987
303. Chasing Their Tails.
- Author
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Barry, Andrew
- Subjects
STOCK prices ,DOW Jones averages ,STOCK exchanges ,STOCKHOLDERS ,INVESTMENTS - Abstract
Reports on the failed economic strategy, the contrarian strategy, for buying Dow Jones stocks. Poor stock performance of the first-half of 2000; Reasons for high losses including major declines in industrial stocks DuPont, Caterpillar, and International Paper; Disfavor of the strategy among investors.
- Published
- 2000
304. From paradox to policy : the problem of energy resource conservation in Britain and America, 1865-1981
- Author
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Turnbull, Thomas, Barry, Andrew, and Powell, Richard
- Subjects
333.791 ,history of science ,resource geography ,Historical geography ,energy conservation ,energy history ,energy geography ,systems theory - Abstract
The idea that we can 'save energy' has become a commonplace homily. But with a moment's reflection it is clear there is nothing self-evident about saving energy. Do we save fuel or a system's ability to 'do work'? Do we conserve for perpetuity or to prolong use? Is the motivation resource economy, scarcity, productivity, or - more recently - climate change mitigation? And what stops the fruits of individual parsimony being consumed elsewhere? This thesis offers a history of the idea that we can conserve energy by using it more efficiently. In recounting this story, it is argued that conserved energy is a 'metrological resource' produced by practices of measurement, calculation, and computation. A second argument is that the history of ERC offers an under examined example of a 'resource ontology'; the social processes through which nature is imbued with utility and value. Accordingly, the study of, what is termed, energy resource conservation (ERC herein) involved a novel research method which focused upon the scientific and intellectual processes of resource making, as much as the material. This thesis begins in 1865 with the publication of William Jevons' The Coal Question (1865), in which the resource conservative principles of Classical political economy were overturned. Jevons argued that increased efficiency of coal use would serve only to increase the rate and scale with which coal was used. Proceeding from this anti-thesis, the following chapters outline how, irrespective of Jevons' claim, policies based on the principles of scientific management were applied to the conservation of fuel resources for conserving natural resources. In pre-war America, a complex system of 'pro-rationing' extraction licenses were introduced to conserve the productive capacity of petroleum wells. However, a significant shift occurred during the Cold War, as the conservation of fuel became increasingly conflated with the econometrician's notion of efficient resource allocation. But the most significant developments occurred in the nineteen-seventies, in response to a perceived crisis in energy supply. Fuel policy became a more systemic 'energy policy', which drew on scientific management, graph theory, systems theory, statistical mechanics, and computational econometrics in an attempt to quantify and demonstrate how society could act to conserve energy resources by increasing the efficiency of energy use. The resulting science, and its concomitant policies were an odd mix of cold war rational decision making theories, détente science, scientific radicalism, and liberal economic theory, all given a countercultural and environmentalist gloss in the latter half of the decade. On the basis of this conflation of ideas, a new approach to energy saving that emerged, which transformed the principles of energy resource governance, shifting the onus to conserve from producer to consumer, with distinct implications for post-war theories of political economy.
- Published
- 2017
305. TCI attracts attention in picked-over convertibles market.
- Author
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Barry, Andrew
- Subjects
CONVERTIBLE securities - Abstract
Evaluates the investment viability of a convertible security from Tele-Communications Inc. (TCI) in August 1996. The complex transaction in which Viacom sold its cable systems to TCI; The TCI issue as one of the most attractive in the market, according to some; TCI's chief executive, John Malone; Concerns about cable's fundamentals given the growth in satellite television; The strategy of investing in local-currency, short-term debt securities in the developing world.
- Published
- 1996
306. What must Salomon, Lehman do to get somebody to notice?
- Author
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Barry, Andrew
- Subjects
U.S. dollar ,FINANCE - Abstract
Reports on the lack of interest of investors in the stock of the investment bank Salomon Brothers. Comparison with the performance of the stocks of Merrill Lynch and Morgan Stanley; Dollar's drop against the German mark; Effect of the resignation of Argentine Economic Minister Domingo Cavallo on Argentina's Brady bonds.
- Published
- 1996
307. Tiger's role in a Korean offering draws criticism on Wall Street.
- Author
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Barry, Andrew
- Subjects
- KOREA Mobile Telecommunications Corp., TIGER Management Corp.
- Abstract
Reports on the role of Time Management Corp. in the planned public offering of Korea Mobile Telecommunications Corp. in the United States. Underwriting of the offer by a Goldman Sachs group; Plan to offer 20 million American depositary shares; Concerns on the expected financial windfall for Tiger in connection with the offering.
- Published
- 1996
308. Milestone from the litigious society: The lawsuit-linked certificate.
- Author
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Barry, Andrew
- Subjects
THRIFT institutions - Abstract
Reports on developments on thrift banks in the United States as of August 14, 1995. California Federal Bank's issuance of lawsuit-linked shareholder certificates; Rise on the share prices of defunct Meritor Savings Bank; Glendale Federal Bank's warrants for its common shares; List of institutions with lawsuits against the government.
- Published
- 1995
309. Hoping to avoid taking a bath, a Wall Street firm brings back the kitchen-sink bond.
- Author
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Barry, Andrew and Ward, Sandra
- Subjects
FINANCIAL services industry - Abstract
Reports on developments in the United States financial services industry as of June 12, 1995. Includes CS First Boston's efforts to revive the kitchen-sink bond; Increase in the demand for derivatives; Increase in corporate bond issuance and mortgage refinancing.
- Published
- 1995
310. Has Greenspan given the green light to buying bonds with borrowed money?
- Author
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Barry, Andrew
- Subjects
BONDS (Finance) - Abstract
Reports on the effects of Federal Reserve Board chairman Alan Greenspan's policies on the market for leveraged bonds in the United States. Improvement in trading; Reduction of risks for investors; Increased arbitrage activity by bond dealers.
- Published
- 1995
311. Traders to Greenspan: Make our day.
- Author
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Barry, Andrew
- Subjects
STOCK exchanges ,FUTURES - Abstract
Reports on the actions of bond speculators in the week ended January 6, 1995 in expectation of significant tightening by the Federal Reserve. Purchase of March and June Eurodollar futures contracts.
- Published
- 1995
312. Dean Witter muni funds feel rate pinch, move to reduce payouts.
- Author
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Barry, Andrew
- Subjects
MUNICIPAL bonds ,BOND funds - Abstract
Reports on the performance of leveraged closed-end municipal bond funds in the week ended January 6, 1995. Dividend cuts in six funds managed by Dean Witter; Use of leveraged funds to augment dividends.
- Published
- 1995
313. Leveraged follies, cont'd.
- Author
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Barry, Andrew
- Subjects
BONDS (Finance) ,LEVERAGED buyouts - Abstract
Focuses on leveraged bond strategies in Orange County, California. Significance of the mortgage funds sold abroad by Morgan Stanley in late 1993 and early 1994; Purchase of adjustable-rate mortgage securities; Need for the funds to be liquidated.
- Published
- 1994
314. Golden lining.
- Author
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Barry, Andrew
- Subjects
MUNICIPAL bonds ,PUBLIC debts - Abstract
Reports that municipal bond insurers are beneficiaries in the bankruptcy of Orange County, California. Comments from Marty Whitman of M.J. Whitman & Co.; Recoup of all the payments advanced to bondholders; Rise in investor demand for insurance on their municipalities.
- Published
- 1994
315. Who's afraid of a shaky market?
- Author
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Barry, Andrew
- Subjects
FEDERAL home loan banks ,PUBLIC debts - Abstract
Reports on Federal Home Loan Banks' selling of bond issues in the middle of Orange County, California's bankruptcy. Opinion of Wall Street dealers; Implication in the agency debt market; Competitive bidding.
- Published
- 1994
316. What's Orange County debt worth? Eventually, 100 cents on the dollar; but not yet.
- Author
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Barry, Andrew
- Subjects
PUBLIC debts - Abstract
Focuses on developments regarding the Orange County, California's debt. County's filing of bankruptcy; Comments from a noted investor in distressed securities, Marty Whitman of M.J. Whitman & Co.; Investors' post-petition interest.
- Published
- 1994
317. DLJ seen ponying up on soured deals; Equitable holders may suffer as a result.
- Author
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Barry, Andrew
- Subjects
COMMERCE - Abstract
Reports on developments in trade in the United States as of November 14, 1994. Purchase of the securities at the original yield; Physical deterioration of the apartment complexes; Decline in rent rolls.
- Published
- 1994
318. Slimm Pickin's in junk bonds.
- Author
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Barry, Andrew
- Subjects
JUNK bonds - Abstract
Reports on the strong showing of junk bonds in 1993 in the United States. Factors contributing to the performance of junk bonds; David Glancy; Fidelity Spartan High Income.
- Published
- 1994
319. Politics of transparency : contested spaces of corporate responsibility, science and regulation in shale gas projects of the UK and the US
- Author
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Kök-Kalaycı, İrem, Clark, Gordon L., and Barry, Andrew
- Subjects
333.8 ,Shale gas industry--Environmental aspects--Great Britain ,Shale gas industry--Environmental aspects--United States ,Social responsibility of business ,Transparency in government ,Energy policy ,Environmental responsibility - Abstract
This thesis presents a political geography of transparency, regulation and resource making in shale gas projects in the United Kingdom (UK) and the United States (US). The emergence of shale gas as a politically and economically desirable resource occupied national political aspirations, most notably in the US and to some extent in the UK, for reasons of energy security and economic development. Although shale gas has become a globally desirable resource, this thesis shows that the resource is not same everywhere. Following knowledge making practices in distinct regulatory regimes of the UK and the US, I trace how making of shale gas resource is subjected to contestation in a range of technical fields, such as law, economics, geosciences and environmental impact assessment. The study is based on in-depth analysis of technical and policy documents, and interviews with a wide range of actors (i.e. regulators, gas companies, investors, scientists, landowners), and field visits in the US (New York, Pennsylvania and Texas) and the UK (Lancashire, Litchfield and London). Drawing on theoretical insights from the Science and Technology Studies (STS), legal and resource geographies, I empirically showed that both regulatory practices and resource materialities matter in encapsulating making of shale gas projects in different national contexts. Documenting how information production and its contestation is entangled with assemblages of materials and technologies, as well as regulatory, geoscientific and market interventions in the context of the UK and the US, this thesis offers an alternative account of the geography of transparency and regulation regarding the development of shale gas policies. The political viability of shale projects depends on how these informational spaces are generated, contested and transformed in nationally specific scientific practices and regulatory regimes.
- Published
- 2016
320. Space, research objects, and interdisciplinarity in geomorphological inquiry
- Author
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Tily, Rachael, Barry, Andrew, and Powell, Richard
- Subjects
551.41 - Abstract
This thesis considers (inter)disciplinary spaces and research objects associated with geomorphology. Employing an ethnographic methodology, established Actor-Network Theory (ANT) themes are examined; the study considers the displacement of research objects amid the spaces of scientific inquiry and the role played by a range of actors in enabling this displacement. However, these well-known themes are given new impetus; the thesis seeks to address deficiencies in ANT accounts of space and it offers an alternative approach to conceptualising scientific research objects. Building on this analysis it considers how the spaces of geomorphological inquiry are reworked to accommodate interdisciplinary research objects. In this way, the study provides a strong theoretical contribution to the literature. However, this theoretical contribution is complemented by an important empirical base. The study is one of only a few Science and Technology Studies (STS) analyses to consider the geosciences. Focusing on late twentieth and early twenty-first century geomorphology, it provides an insight into an interdisciplinary field of research found in both geography and geology departments. In this way it offers an important contribution to the histories of geography literature and the literature on interdisciplinarity. Relatedly, through its attention to the interdisciplinary field of biogeomorphology, the study provides a bridge between existing STS literatures on the biosciences and nascent explorations of the geosciences.
- Published
- 2016
321. Sustainability's paradox : community health, climate change and petrocapitalism
- Author
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Freeland Ballantyne, Erin, Barry, Andrew, and Thornton, Thomas
- Subjects
305.897 ,Chipewyan Indians ,Petroleum industry and trade--Canada ,Pipelines--Environmental aspects ,Political ecology ,Climatic changes--Canada ,Northern ,Protest movements--Canada ,Northwest Territories--Race relations ,Northwest Territories--Social conditions--Case studies - Published
- 2013
322. Unconventional futures : anticipation, materiality, and the market in oil shale development
- Author
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Kama, Kärg and Barry, Andrew
- Subjects
333.8 ,Geography ,History of technology ,Technologies of politics and ecology ,Material anthropology ,Political economy of markets and states ,EU Law ,natural resources ,energy geographies ,energy politics ,oil shale ,unconventional oil ,futures ,materiality ,marketization ,Estonia ,Jordan ,Utah - Abstract
This thesis offers a political geography of unconventional energy development through a study of a particular fossil fuel resource called oil shale. Having long occupied a critical place in the politics and economy of certain states, most notably in Estonia, oil shale is now widely known as an ‘unconventional’ resource that is yet to become technically possible, commercially viable and socially acceptable to exploit. Following the movement through which oil shale becomes both unconventional and conventional, the thesis traces the resource through a series of geo-scientific, economic and political interventions. This study is based on analysis of technical literature and policy documents along with ethnographic fieldwork, interviews, and site visits conducted in Estonia, Colorado, Utah, Jordan, London and Brussels. Drawing together relational accounts of natural resources in political ecology and economic geography with insights from Science and Technology Studies, this project both contributes to critical research on the carbon economy and to recent debates on the concepts of materiality, anticipation, and marketization in social sciences. The thesis proposes a relational conceptualization of resource materiality, situating oil shale in multiple and conflicting forms which derive from geographically disparate practices in both resource assessment and technological development. The future of oil shale exploitation is not pre-determined by the process of global resource decline, nor is it precluded by international demands to move towards lower-carbon futures. Rather, it is determined through the conjunction of different future-oriented economic and political calculations that are entangled with resource materials and associated technological systems. Developing a non-essentialist account of markets as socio-technically distributed arrangements, the thesis argues that these rival calculations influence the design of market rules for both energy and emissions trading. The thesis concludes that what counts as ‘unconventional’ is not given, but continues to be both created and contested at the same time as it is ‘conventionalized’.
- Published
- 2013
323. Managing nature, producing cultures : Inuit participation, science and policy in wildlife governance in the Nunavut Territory, Canada
- Author
-
Henri, Dominique, Barry, Andrew, and Thornton, Thomas
- Subjects
333.72097192 ,Geography ,History of science ,Anthropology of policy ,Governance and ethics ,Indigenous peoples ,Public policy ,Environment ,Inuit ,Nunavut ,governance ,wildlife co-management ,polar bear ,common eider - Abstract
In this thesis, a critical analysis is proposed of the relationships between Inuit participation, science and policy in wildlife governance in the Nunavut Territory, Canada. This analysis situates the emergence of a participatory regime for the governance of wildlife in Nunavut, explores its performance and examines the relations between the ways in which wildlife governance arrangements are currently represented in policy and how they are played out in practice across the territory. To pursue these objectives, this research draws upon a number of theoretical perspectives and methodological strategies poised at a crossroads between environmental geography, science and technology studies, political ecology and ecological anthropology. It combines participant observation, semi-directed interviews and literature-based searches with approaches to the study of actor-networks, hybrid forums and scientific practices associated with Latour and Callon, as well as with Foucauldian and post-Foucauldian analyses of power, governmentality and subjectivity. This analysis suggests that the overall rationale within which wildlife governance operates in Nunavut remains largely based on a scientific and bureaucratic framework of resource management that poses significant barriers to the meaningful inclusion of Inuit views. In spite of their participation in wildlife governance through a range of institutional arrangements, consultation practices and research initiatives, the Inuit of Nunavut remain critical of the power relations embedded within existing schemes, where significant decision-making authority remains under the control of the territorial (or federal) government, and where asymmetries persist with regard to the capacity of various actors to produce and mediate their claims. In addition, while the use of Inuit knowledge, or Inuit Qaujimajatuqangit, in wildlife governance in Nunavut has produced some collaborative research and management endeavours, it has also crystallised a divide between ‘Inuit’ and ‘scientific’ knowledge, generated unresolved conflicts, fuelled mistrust among wildlife co-management partners and led to an overall limited inclusion of Inuit observations, values and beliefs in decision-making.
- Published
- 2012
324. Corporate foundations in the mining industry : institutional challenges to private sector involvement in development
- Author
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McElroy, Caitlin, Clark, Gordon, and Barry, Andrew
- Subjects
338.7622 ,Learning facilitation ,Innovation, productivity and growth ,International business ,Business and Management ,Africa ,Geographic region ,Latin America ,Local Government ,Geography - Abstract
This thesis investigates the rise and performance of corporate foundations in the mining industry. Corporate foundations work to distribute the benefits of mining activities in developing countries. They are a hybrid organizational form that is connected to the funding and founding corporation, and yet to different degrees they independently govern their resources and activities. In addressing the problem of uneven benefit distribution, they are related to a growing interest in improved corporate social responsibility. This thesis examines corporate foundations' forms and functions from an economic geography perspective that situates their rise and performance within the diversity and heterogeneity of economic activities that formulate the current context of the political economy of the mining industry. Through an overarching framework of organization and institutional theory the thesis investigates if: 1) corporate foundations in the mining industry are fit for purpose; 2) how the form of corporate foundations influences function, and vice-versa; and 3) how are these foundations shaped by, and in turn shaping, their (corporate/local/regional/national economic/regulatory/political/social) environments? It finds that corporate foundations in the mining industry currently lack a larger strategy to articulate the goal of their long-term performance. This is based on the findings of the empirical chapters that: 1) the organizational legitimacy of corporate foundations is particularly related to their form; 2) that problems of local failure to distribute benefit are an underdeveloped aspect of the resource curse, and requires close coordination with the technical changes of the mining industry and their effects on the regional population to manage; 3) that corporate foundations represent the path dependency of the mining industry, but when operated with a specific strategy for change are able to affect evolutionary institutional change in corporations; and 4) that the hybrid form of corporate foundations is best suited to build capacity and foster partnerships that facilitate processes of regional economic development through improved economic linkages with the mining industry. From these findings, the conclusion proposes that corporate foundations should adopt a strategy to serve as a mediator between mining corporations and the region to build institutional capacities and partnerships to facilitate the distribution of benefits from mining.
- Published
- 2012
325. Know Your Stakeholders.
- Author
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Barry, Andrew
- Subjects
STAKEHOLDERS ,AUTOMATION ,LIQUIDS - Abstract
The article explains the importance of understanding the need of stakeholders before implementing liquid handling automation.
- Published
- 2011
326. Governmentality: Power and Rule in Modern Society.
- Author
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Barry, Andrew
- Subjects
- *
GOVERNMENTALITY , *NONFICTION - Abstract
The article reviews the book "Governmentality: Power and Rule in Modern Society," by Mitchell Dean.
- Published
- 2000
- Full Text
- View/download PDF
327. Book Reviews.
- Author
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Barry, Andrew
- Subjects
- COORDINATING Technology (Book)
- Abstract
Reviews the book `Coordinating Technology: Studies in the International Standardization of Telecommunications,' by Susanne K. Schmidt and Raymund Werle.
- Published
- 2000
328. Taste, ethics and the market in Guatemalan coffee : an ethnographic study
- Author
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Barth, Jennifer, Barry, Andrew, and Bell, Vikki
- Subjects
330.9 ,Geography ,Economic Geography ,Social Geography ,coffee ,ethical coffee ,fair trade ,taste ,affect ,quality ,Guatemala ,ethnography - Abstract
For more than two decades there has been a growing niche for ethically sourced coffees, at the same time as a revitalisation and development of sourcing models focused on indicators of coffee quality and measures of taste. Small independent and multinational buyers and roasters have become progressively interested in sourcing coffee in a way that privileges sustainable and/or high quality indicators, and are increasingly engaged in debates about solidarity versus mainstreaming, quantity versus quality, and provider of caffeine versus taste. Research on one coffee producing country, Guatemala, suggests how these debates have affected the historical evolution of the coffee market. This ethnographic study traces the qualifications of Guatemalan coffee and argues that responses to both the enactment of the technologies, as well as the perceived limitations of sourcing models have produced new articulations of ethics and taste. Producers and small entrepreneurs located in Guatemala reconfigure the practices of cultivation, processing, and selling/buying in relation to circulating market indicators. They create locally situated attachments to the coffee through skill transfer and knowledge exchange and in this way they imitate and also transform international valuations of taste, ethics and quality. This thesis works to make visible the range and diversity of processes and agencies involved in the production of markets for ethical coffee and considers coffee as vital and mobile; an active producer of public effects rather than a passive object moved through a commodity network. This view enables a more open, relational and mobile account of both coffee and of ethics, one which is capable of making clear the important and emerging role of taste. This thesis extends the qualifications of coffee to the daily enactments of cultivation and the skills and techniques that work to reveal taste. On this view, taste mediates the agency of the materials in both high quality and sustainable coffees and this expands and extends ethics to interpersonal, material and bodily relations that link producers and consumers in multiple ways.
- Published
- 2010
329. Book reviews.
- Author
-
Barry, Andrew
- Subjects
- VIEWING the Earth (Book)
- Abstract
Reviews the book `Viewing the Earth: The Social Construction of the Landsat Satellite System,` by Pamela E. Mack.
- Published
- 1992
330. Book reviews.
- Author
-
Barry, Andrew
- Subjects
- LAUNCHING Europe (Book)
- Abstract
Reviews the book `Launching Europe: An Ethnography of European Cooperation in Space Science,' by Stacia E. Zabusky.
- Published
- 1996
331. A politician's best friend in a social revolution.
- Author
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Barry, Andrew
- Subjects
- *
SOCIAL sciences , *NONFICTION - Abstract
Reviews the book 'Tank: The Progress of a Monstrous War Machine,' by Patrick Wright.
- Published
- 2001
332. Between science and fiction.
- Author
-
Barry, Andrew
- Subjects
- WE Have Never Been Modern (Book)
- Abstract
Reviews the book `We Have Never Been Modern,' by Bruno Latour.
- Published
- 1994
333. Visible differences.
- Author
-
Barry, Andrew
- Subjects
- CULTURAL Babbage (Book)
- Abstract
Reviews the book `Cultural Babbage: Technology, Time and Invention,' edited by Jenny Uglow and Francis Spufford.
- Published
- 1996
334. Interventions in the political geographies of ‘area’.
- Author
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Powell, Richard C., Klinke, Ian, Jazeel, Tariq, Daley, Patricia, Kamata, Ng’wanza, Heffernan, Michael, Swain, Adam, McConnell, Fiona, Barry, Andrew, and Phillips, Richard
- Subjects
- *
POLITICAL geography , *GEOPOLITICS , *POLITICAL science , *AREA studies , *THOUGHT & thinking - Published
- 2017
- Full Text
- View/download PDF
335. Exome Sequencing, ANGPTL3 Mutations, and Familial Combined Hypolipidemia.
- Author
-
Musunuru, Kiran, Pirruccello, James P., Do, Ron, Peloso, Gina M., Guiducci, Candace, Sougnez, Carrie, Garimella, Kiran V., Fisher, Sheila, Abreu, Justin, Barry, Andrew J., Fennell, Tim, Banks, Eric, Ambrogio, Lauren, Cibulskis, Kristian, Kernytsky, Andrew, Gonzalez, Elena, Rudzicz, Nicholas, Engert, James C., DePristo, Mark A., and Daly, Mark J.
- Subjects
- *
PROTEINS , *GENOMES , *HYPOLIPEMIA , *CHOLESTEROL , *TRIGLYCERIDES , *GENETIC mutation - Abstract
We sequenced all protein-coding regions of the genome (the “exome”) in two family members with combined hypolipidemia, marked by extremely low plasma levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. These two participants were compound heterozygotes for two distinct nonsense mutations in ANGPTL3 (encoding the angiopoietin-like 3 protein). ANGPTL3 has been reported to inhibit lipoprotein lipase and endothelial lipase, thereby increasing plasma triglyceride and HDL cholesterol levels in rodents. Our finding of ANGPTL3 mutations highlights a role for the gene in LDL cholesterol metabolism in humans and shows the usefulness of exome sequencing for identification of novel genetic causes of inherited disorders. (Funded by the National Human Genome Research Institute and others.) [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
336. Soil erosion due to rainfall impact with inflow: an analytical solution with spatial and temporal effects
- Author
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Hogarth, W.L., Parlange, J.-Y., Rose, C.W., Sander, G.C., Steenhuis, T.S., and Barry, Andrew
- Subjects
- *
SOIL erosion , *RAINFALL , *EMPIRICAL research , *SEDIMENTATION & deposition - Abstract
An approximate analytical solution is obtained for a physically based model of soil erosion on a gentle slope driven by rainfall impact in which there is inflow of clear or nearly clear water to the top of the soil bed. Comparison of the approximate analytical and numerical solutions shows very good agreement, except for the first few minutes of an erosion event. The approximate analytic solution is applied using data from an illustrative experiment to explore its physical features. The importance of adequately defining the soil''s settling velocity characteristic through the use of a sufficient number of sediment size classes, especially for prediction at short times, is illustrated. The temporal variation in sediment concentration, except at short times, is shown to be more significant than the spatial variation down the eroding surface. Solution of the equations allows visualization of the rate of convective transport of sediment down the eroding surface, this rate decreasing as sediment size increased due to more frequent return of such particles to the soil surface in deposition. [Copyright &y& Elsevier]
- Published
- 2004
- Full Text
- View/download PDF
337. Pushbroom Stereo for High-Speed Navigation in Cluttered Environments
- Author
-
Andrew J. Barry, Russ Tedrake, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Barry, Andrew J., and Tedrake, Russell Louis
- Subjects
FOS: Computer and information sciences ,business.industry ,Computer science ,Computer Vision and Pattern Recognition (cs.CV) ,Computer Science - Computer Vision and Pattern Recognition ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,Frame rate ,Computer Science - Robotics ,Stereopsis ,Inertial measurement unit ,Position (vector) ,Obstacle ,Clutter ,Computer vision ,Artificial intelligence ,business ,Robotics (cs.RO) - Abstract
We present a novel stereo vision algorithm that is capable of obstacle detection on a mobile ARM processor at 120 frames per second. Our system performs a subset of standard block-matching stereo processing, searching only for obstacles at a single depth. By using an onboard IMU and state-estimator, we can recover the position of obstacles at all other depths, building and updating a local depth-map at framerate. Here, we describe both the algorithm and our implementation on a high-speed, small UAV, flying at over 20 MPH (9 m/s) close to obstacles. The system requires no external sensing or computation and is, to the best of our knowledge, the first high-framerate stereo detection system running onboard a small UAV., United States. Office of Naval Research. Multidisciplinary University Research Initiative (Grant N00014-09-1-1051), National Science Foundation (U.S.). Graduate Research Fellowship
- Published
- 2014
- Full Text
- View/download PDF
338. Joint base-calling of two DNA sequences with factor graphs
- Author
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R. Kotter, Muriel Medard, James Meldrim, Desmond S. Lun, Xiaomeng Shi, A.J. Barry, Shi, Xiaomeng, Lun, Desmond S, Médard, Muriel, Kötter, Ralf, Meldrim, James C, and Barry, Andrew J
- Subjects
factor graphs ,Computer science ,Genomics ,02 engineering and technology ,Library and Information Sciences ,DNA sequencing ,Data modeling ,base-calling ,03 medical and health sciences ,chemistry.chemical_compound ,DNA modeling ,0202 electrical engineering, electronic engineering, information engineering ,030304 developmental biology ,0303 health sciences ,Basis (linear algebra) ,Heuristic ,sum-product algorithm ,020206 networking & telecommunications ,Statistical model ,Computer Science Applications ,chemistry ,Base calling ,Algorithm ,Factor graph ,DNA ,Information Systems - Abstract
Automated estimation of DNA base-sequences is an important step in genomics and in many other emerging fields in biological and medical sciences. Current automated sequencers process single strands only. To improve the utility of existing technologies, we propose to mix two independent strands prior to electrophoresis, and base-call jointly by applying the sum-product algorithm on factor graphs. We first present a statistical model for DNA sequencing data and examine the model parameters. A practical heuristic is then proposed to estimate the peaks, which are then separated into two source sequences (Major/Minor) bypassing messages on a factor graph. Simulation results show that joint base-calling can provide less accurate but valid results for the minor. The algorithm presented provides a basis for future investigation of joint sequencing techniques. Refereed/Peer-reviewed
- Published
- 2010
339. An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery.
- Author
-
Huang Q, Chan KY, Wu J, Botticello-Romero NR, Zheng Q, Lou S, Keyes C, Svanbergsson A, Johnston J, Mills A, Lin CY, Brauer PP, Clouse G, Pacouret S, Harvey JW, Beddow T, Hurley JK, Tobey IG, Powell M, Chen AT, Barry AJ, Eid FE, Chan YA, and Deverman BE
- Subjects
- Animals, Humans, Mice, Blood-Brain Barrier metabolism, Capsid Proteins metabolism, Capsid Proteins genetics, Dependovirus, Endothelial Cells metabolism, Gene Knock-In Techniques, Genetic Therapy, Gaucher Disease genetics, Gaucher Disease therapy, Parkinson Disease genetics, Parkinson Disease therapy, Antigens, CD metabolism, Antigens, CD genetics, Brain metabolism, Capsid metabolism, Gene Transfer Techniques, Genetic Vectors, Receptors, Transferrin metabolism, Receptors, Transferrin genetics, Glucosylceramidase genetics
- Abstract
Developing vehicles that efficiently deliver genes throughout the human central nervous system (CNS) will broaden the range of treatable genetic diseases. We engineered an adeno-associated virus (AAV) capsid, BI-hTFR1, that binds human transferrin receptor (TfR1), a protein expressed on the blood-brain barrier. BI-hTFR1 was actively transported across human brain endothelial cells and, relative to AAV9, provided 40 to 50 times greater reporter expression in the CNS of human TFRC knockin mice. The enhanced tropism was CNS-specific and absent in wild-type mice. When used to deliver GBA1 , mutations of which cause Gaucher disease and are linked to Parkinson's disease, BI-hTFR1 substantially increased brain and cerebrospinal fluid glucocerebrosidase activity compared with AAV9. These findings establish BI-hTFR1 as a potential vector for human CNS gene therapy.
- Published
- 2024
- Full Text
- View/download PDF
340. An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery.
- Author
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Huang Q, Chan KY, Lou S, Keyes C, Wu J, Botticello-Romero NR, Zheng Q, Johnston J, Mills A, Brauer PP, Clouse G, Pacouret S, Harvey JW, Beddow T, Hurley JK, Tobey IG, Powell M, Chen AT, Barry AJ, Eid FE, Chan YA, and Deverman BE
- Abstract
Developing vehicles that efficiently deliver genes throughout the human central nervous system (CNS) will broaden the range of treatable genetic diseases. We engineered an AAV capsid, BI-hTFR1, that binds human Transferrin Receptor (TfR1), a protein expressed on the blood-brain barrier (BBB). BI-hTFR1 was actively transported across a human brain endothelial cell layer and, relative to AAV9, provided 40-50 times greater reporter expression in the CNS of human TFRC knock-in mice. The enhanced tropism was CNS-specific and absent in wild type mice. When used to deliver GBA1 , mutations of which cause Gaucher disease and are linked to Parkinson's disease, BI-hTFR1 substantially increased brain and cerebrospinal fluid glucocerebrosidase activity compared to AAV9. These findings establish BI-hTFR1 as a promising vector for human CNS gene therapy., Competing Interests: Competing interests B.E.D is a scientific founder and scientific advisory board member at Apertura Gene Therapy and a scientific advisory board member at Tevard Biosciences. B.E.D., A.J.B., K.Y.C., F.E.E., Q.H., J.W., and N.R.B.R. are named inventors on patent applications filed by the Broad Institute of MIT and Harvard related to this study. Remaining authors declare that they have no competing interests.
- Published
- 2023
- Full Text
- View/download PDF
341. Metamorphosis in Insect Muscle: Insights for Engineering Muscle-Based Actuators.
- Author
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Ludwig JC and Trimmer BA
- Subjects
- Animals, Insecta, Myoblasts, Tissue Engineering, Muscles, Robotics
- Abstract
One of the major limitations to advancing the development of soft robots is the absence of lightweight, effective soft actuators. While synthetic systems, such as pneumatics and shape memory alloys, have created important breakthroughs in soft actuation, they typically rely on large external power sources and some rigid components. Muscles provide an ideal actuator for soft constructs, as they are lightweight, deformable, biodegradable, silent, and powered by energy-dense hydrocarbons such as glucose. Vertebrate cell lines and embryonic cultures have allowed critical foundational work to this end, but progress there is limited by the difficulty of identifying individual pathways in embryonic development, and the divergence of immortal cell lines from these normal developmental programs. An alternative to culturing muscles from embryonic cells is to exploit the advantages of species with metamorphic stages. In these animals, muscles develop from a predefined pool of myoblasts with well-characterized contacts to other tissues. In addition, the endocrine triggers for development into adult muscles are often known and tractable for experimental manipulation. This is particularly true for metamorphic muscle development in holometabolous insects, which provide exciting new avenues for tissue engineering. Using insect tissues for actuator development confers additional benefits; insect muscles are more robust to varying pH, temperature, and oxygenation than are vertebrate cells. Given that biohybrid robots are likely to be used in ambient conditions and changing environments, this sort of hardiness is likely to be required for practical use. In this study, we summarize key processes and signals in metamorphic muscle development, drawing attention to those pathways that offer entry points for manipulation. By focusing on lessons learned from in vivo insect development, we propose that future culture designs will be able to use more systematic, hypothesis-driven approaches to optimizing engineered muscle. Impact statement This review summarizes our current understanding of metamorphic muscle development in insects. It provides a framework for engineering muscle-based actuators that can be used in robotic applications in a wide range of ambient conditions. The focus is on identifying key processes that might be manipulated to solve current challenges in controlling tissue development such as myoblast proliferation, myotube formation and fusion, cytoskeletal alignment, myotendinous attachment and full differentiation. An important goal is to gather findings that cross disciplinary boundaries and to promote the development of better bioactuators for nonclinical applications.
- Published
- 2021
- Full Text
- View/download PDF
342. Enhancing colorimetric loop-mediated isothermal amplification speed and sensitivity with guanidine chloride.
- Author
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Zhang Y, Ren G, Buss J, Barry AJ, Patton GC, and Tanner NA
- Subjects
- COVID-19 Testing, Clinical Laboratory Techniques standards, Colorimetry, Coronavirus Infections diagnosis, Humans, Molecular Diagnostic Techniques standards, Nucleic Acid Amplification Techniques standards, Phenolsulfonphthalein, SARS-CoV-2, Betacoronavirus isolation & purification, Clinical Laboratory Techniques methods, Guanidine, Molecular Diagnostic Techniques methods, Nucleic Acid Amplification Techniques methods
- Abstract
Loop-mediated isothermal amplification (LAMP) is a versatile technique for detection of target DNA and RNA, enabling rapid molecular diagnostic assays with minimal equipment. The global SARS-CoV-2 pandemic has presented an urgent need for new and better diagnostic methods, with colorimetric LAMP utilized in numerous studies for SARS-CoV-2 detection. However, the sensitivity of colorimetric LAMP in early reports has been below that of the standard RT-qPCR tests, and we sought to improve performance. Here we report the use of guanidine hydrochloride and combined primer sets to increase speed and sensitivity in colorimetric LAMP, bringing this simple method up to the standards of sophisticated techniques and enabling accurate, high-throughput diagnostics.
- Published
- 2020
- Full Text
- View/download PDF
343. Afterword: 'I will play my part!', or parliamentary politics in action.
- Author
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Barry A
- Subjects
- European Union, United Kingdom, Democracy, Politics
- Published
- 2020
- Full Text
- View/download PDF
344. Alzheimer's disease amyloid beta-protein and synaptic function.
- Author
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Ondrejcak T, Klyubin I, Hu NW, Barry AE, Cullen WK, and Rowan MJ
- Subjects
- Acetylcholine metabolism, Animals, Glutamic Acid metabolism, Humans, Long-Term Potentiation physiology, Long-Term Synaptic Depression physiology, Receptors, Cholinergic metabolism, Receptors, N-Methyl-D-Aspartate metabolism, Alzheimer Disease pathology, Alzheimer Disease physiopathology, Amyloid beta-Peptides metabolism, Synapses metabolism, Synaptic Transmission physiology
- Abstract
Alzheimer's disease (AD) is characterized neuropathologically by the deposition of different forms of amyloid beta-protein (A beta) including variable amounts of soluble species that correlate with severity of dementia. The extent of synaptic loss in the brain provides the best morphological correlate of cognitive impairment in clinical AD. Animal research on the pathophysiology of AD has therefore focussed on how soluble A beta disrupts synaptic mechanisms in vulnerable brain regions such as the hippocampus. Synaptic plasticity in the form of persistent activity-dependent increases or decreases in synaptic strength provide a neurophysiological substrate for hippocampal-dependent learning and memory. Acute treatment with human-derived or chemically prepared soluble A beta that contains certain oligomeric assemblies, potently and selectively disrupts synaptic plasticity causing inhibition of long-term potentiation (LTP) and enhancement of long-term depression (LTD) of glutamatergic transmission. Over time these and related actions of A beta have been implicated in reducing synaptic integrity. This review addresses the involvement of neurotransmitter intercellular signaling in mediating or modulating the synaptic plasticity disrupting actions of soluble A beta, with particular emphasis on the different roles of glutamatergic and cholinergic mechanisms. There is growing evidence to support the view that NMDA and possibly nicotinic receptors are critically involved in mediating the disruptive effect of A beta and that targeting muscarinic receptors can indirectly modulate A beta's actions. Such studies should help inform ongoing and future clinical trials of drugs acting through the glutamatergic and cholinergic systems.
- Published
- 2010
- Full Text
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345. Evolution of genes and genomes on the Drosophila phylogeny.
- Author
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Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B, Markow TA, Kaufman TC, Kellis M, Gelbart W, Iyer VN, Pollard DA, Sackton TB, Larracuente AM, Singh ND, Abad JP, Abt DN, Adryan B, Aguade M, Akashi H, Anderson WW, Aquadro CF, Ardell DH, Arguello R, Artieri CG, Barbash DA, Barker D, Barsanti P, Batterham P, Batzoglou S, Begun D, Bhutkar A, Blanco E, Bosak SA, Bradley RK, Brand AD, Brent MR, Brooks AN, Brown RH, Butlin RK, Caggese C, Calvi BR, Bernardo de Carvalho A, Caspi A, Castrezana S, Celniker SE, Chang JL, Chapple C, Chatterji S, Chinwalla A, Civetta A, Clifton SW, Comeron JM, Costello JC, Coyne JA, Daub J, David RG, Delcher AL, Delehaunty K, Do CB, Ebling H, Edwards K, Eickbush T, Evans JD, Filipski A, Findeiss S, Freyhult E, Fulton L, Fulton R, Garcia AC, Gardiner A, Garfield DA, Garvin BE, Gibson G, Gilbert D, Gnerre S, Godfrey J, Good R, Gotea V, Gravely B, Greenberg AJ, Griffiths-Jones S, Gross S, Guigo R, Gustafson EA, Haerty W, Hahn MW, Halligan DL, Halpern AL, Halter GM, Han MV, Heger A, Hillier L, Hinrichs AS, Holmes I, Hoskins RA, Hubisz MJ, Hultmark D, Huntley MA, Jaffe DB, Jagadeeshan S, Jeck WR, Johnson J, Jones CD, Jordan WC, Karpen GH, Kataoka E, Keightley PD, Kheradpour P, Kirkness EF, Koerich LB, Kristiansen K, Kudrna D, Kulathinal RJ, Kumar S, Kwok R, Lander E, Langley CH, Lapoint R, Lazzaro BP, Lee SJ, Levesque L, Li R, Lin CF, Lin MF, Lindblad-Toh K, Llopart A, Long M, Low L, Lozovsky E, Lu J, Luo M, Machado CA, Makalowski W, Marzo M, Matsuda M, Matzkin L, McAllister B, McBride CS, McKernan B, McKernan K, Mendez-Lago M, Minx P, Mollenhauer MU, Montooth K, Mount SM, Mu X, Myers E, Negre B, Newfeld S, Nielsen R, Noor MA, O'Grady P, Pachter L, Papaceit M, Parisi MJ, Parisi M, Parts L, Pedersen JS, Pesole G, Phillippy AM, Ponting CP, Pop M, Porcelli D, Powell JR, Prohaska S, Pruitt K, Puig M, Quesneville H, Ram KR, Rand D, Rasmussen MD, Reed LK, Reenan R, Reily A, Remington KA, Rieger TT, Ritchie MG, Robin C, Rogers YH, Rohde C, Rozas J, Rubenfield MJ, Ruiz A, Russo S, Salzberg SL, Sanchez-Gracia A, Saranga DJ, Sato H, Schaeffer SW, Schatz MC, Schlenke T, Schwartz R, Segarra C, Singh RS, Sirot L, Sirota M, Sisneros NB, Smith CD, Smith TF, Spieth J, Stage DE, Stark A, Stephan W, Strausberg RL, Strempel S, Sturgill D, Sutton G, Sutton GG, Tao W, Teichmann S, Tobari YN, Tomimura Y, Tsolas JM, Valente VL, Venter E, Venter JC, Vicario S, Vieira FG, Vilella AJ, Villasante A, Walenz B, Wang J, Wasserman M, Watts T, Wilson D, Wilson RK, Wing RA, Wolfner MF, Wong A, Wong GK, Wu CI, Wu G, Yamamoto D, Yang HP, Yang SP, Yorke JA, Yoshida K, Zdobnov E, Zhang P, Zhang Y, Zimin AV, Baldwin J, Abdouelleil A, Abdulkadir J, Abebe A, Abera B, Abreu J, Acer SC, Aftuck L, Alexander A, An P, Anderson E, Anderson S, Arachi H, Azer M, Bachantsang P, Barry A, Bayul T, Berlin A, Bessette D, Bloom T, Blye J, Boguslavskiy L, Bonnet C, Boukhgalter B, Bourzgui I, Brown A, Cahill P, Channer S, Cheshatsang Y, Chuda L, Citroen M, Collymore A, Cooke P, Costello M, D'Aco K, Daza R, De Haan G, DeGray S, DeMaso C, Dhargay N, Dooley K, Dooley E, Doricent M, Dorje P, Dorjee K, Dupes A, Elong R, Falk J, Farina A, Faro S, Ferguson D, Fisher S, Foley CD, Franke A, Friedrich D, Gadbois L, Gearin G, Gearin CR, Giannoukos G, Goode T, Graham J, Grandbois E, Grewal S, Gyaltsen K, Hafez N, Hagos B, Hall J, Henson C, Hollinger A, Honan T, Huard MD, Hughes L, Hurhula B, Husby ME, Kamat A, Kanga B, Kashin S, Khazanovich D, Kisner P, Lance K, Lara M, Lee W, Lennon N, Letendre F, LeVine R, Lipovsky A, Liu X, Liu J, Liu S, Lokyitsang T, Lokyitsang Y, Lubonja R, Lui A, MacDonald P, Magnisalis V, Maru K, Matthews C, McCusker W, McDonough S, Mehta T, Meldrim J, Meneus L, Mihai O, Mihalev A, Mihova T, Mittelman R, Mlenga V, Montmayeur A, Mulrain L, Navidi A, Naylor J, Negash T, Nguyen T, Nguyen N, Nicol R, Norbu C, Norbu N, Novod N, O'Neill B, Osman S, Markiewicz E, Oyono OL, Patti C, Phunkhang P, Pierre F, Priest M, Raghuraman S, Rege F, Reyes R, Rise C, Rogov P, Ross K, Ryan E, Settipalli S, Shea T, Sherpa N, Shi L, Shih D, Sparrow T, Spaulding J, Stalker J, Stange-Thomann N, Stavropoulos S, Stone C, Strader C, Tesfaye S, Thomson T, Thoulutsang Y, Thoulutsang D, Topham K, Topping I, Tsamla T, Vassiliev H, Vo A, Wangchuk T, Wangdi T, Weiand M, Wilkinson J, Wilson A, Yadav S, Young G, Yu Q, Zembek L, Zhong D, Zimmer A, Zwirko Z, Jaffe DB, Alvarez P, Brockman W, Butler J, Chin C, Gnerre S, Grabherr M, Kleber M, Mauceli E, and MacCallum I
- Subjects
- Animals, Codon genetics, DNA Transposable Elements genetics, Drosophila immunology, Drosophila metabolism, Drosophila Proteins genetics, Gene Order genetics, Genome, Mitochondrial genetics, Immunity genetics, Multigene Family genetics, RNA, Untranslated genetics, Reproduction genetics, Sequence Alignment, Sequence Analysis, DNA, Synteny genetics, Drosophila classification, Drosophila genetics, Evolution, Molecular, Genes, Insect genetics, Genome, Insect genetics, Genomics, Phylogeny
- Abstract
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
- Published
- 2007
- Full Text
- View/download PDF
346. Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- Author
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Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ 3rd, Zody MC, Mauceli E, Xie X, Breen M, Wayne RK, Ostrander EA, Ponting CP, Galibert F, Smith DR, DeJong PJ, Kirkness E, Alvarez P, Biagi T, Brockman W, Butler J, Chin CW, Cook A, Cuff J, Daly MJ, DeCaprio D, Gnerre S, Grabherr M, Kellis M, Kleber M, Bardeleben C, Goodstadt L, Heger A, Hitte C, Kim L, Koepfli KP, Parker HG, Pollinger JP, Searle SM, Sutter NB, Thomas R, Webber C, Baldwin J, Abebe A, Abouelleil A, Aftuck L, Ait-Zahra M, Aldredge T, Allen N, An P, Anderson S, Antoine C, Arachchi H, Aslam A, Ayotte L, Bachantsang P, Barry A, Bayul T, Benamara M, Berlin A, Bessette D, Blitshteyn B, Bloom T, Blye J, Boguslavskiy L, Bonnet C, Boukhgalter B, Brown A, Cahill P, Calixte N, Camarata J, Cheshatsang Y, Chu J, Citroen M, Collymore A, Cooke P, Dawoe T, Daza R, Decktor K, DeGray S, Dhargay N, Dooley K, Dooley K, Dorje P, Dorjee K, Dorris L, Duffey N, Dupes A, Egbiremolen O, Elong R, Falk J, Farina A, Faro S, Ferguson D, Ferreira P, Fisher S, FitzGerald M, Foley K, Foley C, Franke A, Friedrich D, Gage D, Garber M, Gearin G, Giannoukos G, Goode T, Goyette A, Graham J, Grandbois E, Gyaltsen K, Hafez N, Hagopian D, Hagos B, Hall J, Healy C, Hegarty R, Honan T, Horn A, Houde N, Hughes L, Hunnicutt L, Husby M, Jester B, Jones C, Kamat A, Kanga B, Kells C, Khazanovich D, Kieu AC, Kisner P, Kumar M, Lance K, Landers T, Lara M, Lee W, Leger JP, Lennon N, Leuper L, LeVine S, Liu J, Liu X, Lokyitsang Y, Lokyitsang T, Lui A, Macdonald J, Major J, Marabella R, Maru K, Matthews C, McDonough S, Mehta T, Meldrim J, Melnikov A, Meneus L, Mihalev A, Mihova T, Miller K, Mittelman R, Mlenga V, Mulrain L, Munson G, Navidi A, Naylor J, Nguyen T, Nguyen N, Nguyen C, Nguyen T, Nicol R, Norbu N, Norbu C, Novod N, Nyima T, Olandt P, O'Neill B, O'Neill K, Osman S, Oyono L, Patti C, Perrin D, Phunkhang P, Pierre F, Priest M, Rachupka A, Raghuraman S, Rameau R, Ray V, Raymond C, Rege F, Rise C, Rogers J, Rogov P, Sahalie J, Settipalli S, Sharpe T, Shea T, Sheehan M, Sherpa N, Shi J, Shih D, Sloan J, Smith C, Sparrow T, Stalker J, Stange-Thomann N, Stavropoulos S, Stone C, Stone S, Sykes S, Tchuinga P, Tenzing P, Tesfaye S, Thoulutsang D, Thoulutsang Y, Topham K, Topping I, Tsamla T, Vassiliev H, Venkataraman V, Vo A, Wangchuk T, Wangdi T, Weiand M, Wilkinson J, Wilson A, Yadav S, Yang S, Yang X, Young G, Yu Q, Zainoun J, Zembek L, Zimmer A, and Lander ES
- Subjects
- Animals, Conserved Sequence genetics, Dog Diseases genetics, Dogs classification, Female, Humans, Hybridization, Genetic, Male, Mice, Mutagenesis genetics, Polymorphism, Single Nucleotide genetics, Rats, Short Interspersed Nucleotide Elements genetics, Synteny genetics, Dogs genetics, Evolution, Molecular, Genome genetics, Genomics, Haplotypes genetics
- Abstract
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
- Published
- 2005
- Full Text
- View/download PDF
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