1,539 results on '"Barker, Gareth"'
Search Results
352. A Multi-Cohort Study of ApoE epsilon 4 and Amyloid-beta Effects on the Hippocampus in Alzheimer's Disease
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Khan, Wasim, Giampietro, Vincent, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Buechel, Christian, Conrod, Patricia, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Anreas, Ittermann, Bernd, Lemaître, Hervé, Nees, Frauke, Paus, Tomas, Pausova, Zdenka, Rietschel, Marcella, Smolka, Michael N., Ströhle, Andreas, Gallinat, Jeurgen, Vellas, Bruno, Soininen, Hilkka, Kloszewska, Iwona, Tsolaki, Magda, Mecocci, Patrizia, Spenger, Christian, Villemagne, Victor L., Masters, Colin L., Muehlboeck, J-Sebastian, Bäckman, Lars, Fratiglioni, Laura, Kalpouzos, Grégoria, Wahlund, Lars-Olof, Schumann, Gunther, Lovestone, Simon, Williams, Steven C. R., Westman, Eric, Simmons, Andrew, Khan, Wasim, Giampietro, Vincent, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Buechel, Christian, Conrod, Patricia, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Anreas, Ittermann, Bernd, Lemaître, Hervé, Nees, Frauke, Paus, Tomas, Pausova, Zdenka, Rietschel, Marcella, Smolka, Michael N., Ströhle, Andreas, Gallinat, Jeurgen, Vellas, Bruno, Soininen, Hilkka, Kloszewska, Iwona, Tsolaki, Magda, Mecocci, Patrizia, Spenger, Christian, Villemagne, Victor L., Masters, Colin L., Muehlboeck, J-Sebastian, Bäckman, Lars, Fratiglioni, Laura, Kalpouzos, Grégoria, Wahlund, Lars-Olof, Schumann, Gunther, Lovestone, Simon, Williams, Steven C. R., Westman, Eric, and Simmons, Andrew
- Abstract
The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer's disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n = 1,781), we compared the effect of APOE and amyloid-beta (A beta) on baseline hippocampal volumes in AD patients, mild cognitive impairment (MCI) subjects, and healthy controls. A large sample of healthy adolescents (n = 1,387) was also used to compare hippocampal volumes between APOE groups. Subjects had undergone a magnetic resonance imaging (MRI) scan and APOE genotyping. Hippocampal volumes were processed using FreeSurfer. In the AD and normal aging dataset, hippocampal comparisons were performed in each APOE group and in epsilon 4 carriers with positron emission tomography (PET) A beta who were dichotomized (A beta+/A beta-) using previous cut-offs. We found a linear reduction in hippocampal volumes with epsilon 4 carriers possessing the smallest volumes, epsilon 3 carriers possessing intermediate volumes, and epsilon 2 carriers possessing the largest volumes. Moreover, AD and MCI epsilon 4 carriers possessed the smallest hippocampal volumes and control epsilon 2 carriers possessed the largest hippocampal volumes. Subjects with both APOE epsilon 4 and A beta positivity had the lowest hippocampal volumes when compared to A beta-epsilon 4 carriers, suggesting a synergistic relationship between APOE epsilon 4 and A beta. However, we found no hippocampal volume differences between APOE groups in healthy 14-year-old adolescents. Our findings suggest that the strongest neuroanatomic effect of APOE epsilon 4 on the hippocampus is observed in AD and groups most at risk of developing the disease, whereas hippocampi of old and young healthy individuals remain unaffected.
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- 2017
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353. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
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Onderzoeksgroep 4, Brain, Onderzoeksgroep 1, Onderzoeksgroep 11, Onderzoek, Circulatory Health, Guadalupe, Tulio, Mathias, Samuel R., vanErp, Theo G.M., Whelan, Christopher D., Zwiers, Marcel P., Abe, Yoshinari, Abramovic, Lucija, Agartz, Ingrid, Andreassen, Ole A., Arias-Vásquez, Alejandro, Aribisala, Benjamin S., Armstrong, Nicola J., Arolt, Volker, Artiges, Eric, Ayesa-Arriola, Rosa, Baboyan, Vatche G., Banaschewski, Tobias, Barker, Gareth, Bastin, Mark E., Baune, Bernhard T., Blangero, John, Bokde, Arun L.W., Boedhoe, Premika S.W., Bose, Anushree, Brem, Silvia, Brodaty, Henry, Bromberg, Uli, Brooks, Samantha, Büchel, Christian, Buitelaar, Jan, Calhoun, Vince D., Cannon, Dara M., Cattrell, Anna, Cheng, Yuqi, Conrod, Patricia J., Conzelmann, Annette, Corvin, Aiden, Crespo-Facorro, Benedicto, Crivello, Fabrice, Dannlowski, Udo, de Zubicaray, Greig I., de Zwarte, Sonja M.C., Deary, Ian J., Desrivières, Sylvane, Doan, Nhat Trung, Donohoe, Gary, Dørum, Erlend S., Ehrlich, Stefan, Espeseth, Thomas, Fernández, Guillén, Flor, Herta, Fouche, Jean Paul, Frouin, Vincent, Fukunaga, Masaki, Gallinat, Jürgen, Garavan, Hugh, Gill, Michael, Suarez, Andrea Gonzalez, Gowland, Penny, Grabe, Hans J., Grotegerd, Dominik, Gruber, Oliver, Hagenaars, Saskia, Hashimoto, Ryota, Hauser, Tobias U., Heinz, Andreas, Hibar, Derrek P., Hoekstra, Pieter J., Hoogman, Martine, Howells, Fleur M., Hu, Hao, Hulshoff Pol, Hilleke E., Huyser, Chaim, Ittermann, Bernd, Jahanshad, Neda, Jönsson, Erik G., Jurk, Sarah, Kahn, Rene S., Kelly, Sinead, Kraemer, Bernd, Kugel, Harald, Kwon, Jun Soo, Lemaitre, Herve, Lesch, Klaus Peter, Lochner, Christine, Luciano, Michelle, Marquand, Andre F., Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Martinot, Jean Luc, Mataix-Cols, David, Mather, Karen, McDonald, Colm, McMahon, Katie L., Medland, Sarah E., Menchón, José M., Morris, Derek W., Mothersill, Omar, Maniega, Susana Munoz, Mwangi, Benson, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswaamy, Janardhanan C., Nees, Frauke, Nordvik, Jan E., Onnink, A. Marten H., Opel, Nils, Ophoff, Roel, Paillère Martinot, Marie Laure, Papadopoulos Orfanos, Dimitri, Pauli, Paul, Paus, Tomáš, Poustka, Luise, Reddy, Janardhan Yc, Renteria, Miguel E., Roiz-Santiáñez, Roberto, Roos, Annerine, Royle, Natalie A., Sachdev, Perminder, Sánchez-Juan, Pascual, Schmaal, Lianne, Schumann, Gunter, Shumskaya, Elena, Smolka, Michael N., Soares, Jair C., Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Toro, Roberto, Turner, Jessica A., Tzourio-Mazoyer, Nathalie, Uhlmann, Anne, Hernández, Maria Valdés, van den Heuvel, Odile A., van der Meer, Dennis, van Haren, Neeltje E.M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vetter, Nora C., Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wang, Zhen, Wardlaw, Joanna, Wen, Wei, Westlye, Lars T., Whelan, Robert, Wittfeld, Katharina, Wolfers, Thomas, Wright, Margaret J., Xu, Jian, Xu, Xiufeng, Yun, Je Yeon, Zhao, Jing Jing, Franke, Barbara, Thompson, Paul M., Glahn, David C., Mazoyer, Bernard, Fisher, Simon E., Francks, Clyde, Onderzoeksgroep 4, Brain, Onderzoeksgroep 1, Onderzoeksgroep 11, Onderzoek, Circulatory Health, Guadalupe, Tulio, Mathias, Samuel R., vanErp, Theo G.M., Whelan, Christopher D., Zwiers, Marcel P., Abe, Yoshinari, Abramovic, Lucija, Agartz, Ingrid, Andreassen, Ole A., Arias-Vásquez, Alejandro, Aribisala, Benjamin S., Armstrong, Nicola J., Arolt, Volker, Artiges, Eric, Ayesa-Arriola, Rosa, Baboyan, Vatche G., Banaschewski, Tobias, Barker, Gareth, Bastin, Mark E., Baune, Bernhard T., Blangero, John, Bokde, Arun L.W., Boedhoe, Premika S.W., Bose, Anushree, Brem, Silvia, Brodaty, Henry, Bromberg, Uli, Brooks, Samantha, Büchel, Christian, Buitelaar, Jan, Calhoun, Vince D., Cannon, Dara M., Cattrell, Anna, Cheng, Yuqi, Conrod, Patricia J., Conzelmann, Annette, Corvin, Aiden, Crespo-Facorro, Benedicto, Crivello, Fabrice, Dannlowski, Udo, de Zubicaray, Greig I., de Zwarte, Sonja M.C., Deary, Ian J., Desrivières, Sylvane, Doan, Nhat Trung, Donohoe, Gary, Dørum, Erlend S., Ehrlich, Stefan, Espeseth, Thomas, Fernández, Guillén, Flor, Herta, Fouche, Jean Paul, Frouin, Vincent, Fukunaga, Masaki, Gallinat, Jürgen, Garavan, Hugh, Gill, Michael, Suarez, Andrea Gonzalez, Gowland, Penny, Grabe, Hans J., Grotegerd, Dominik, Gruber, Oliver, Hagenaars, Saskia, Hashimoto, Ryota, Hauser, Tobias U., Heinz, Andreas, Hibar, Derrek P., Hoekstra, Pieter J., Hoogman, Martine, Howells, Fleur M., Hu, Hao, Hulshoff Pol, Hilleke E., Huyser, Chaim, Ittermann, Bernd, Jahanshad, Neda, Jönsson, Erik G., Jurk, Sarah, Kahn, Rene S., Kelly, Sinead, Kraemer, Bernd, Kugel, Harald, Kwon, Jun Soo, Lemaitre, Herve, Lesch, Klaus Peter, Lochner, Christine, Luciano, Michelle, Marquand, Andre F., Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Martinot, Jean Luc, Mataix-Cols, David, Mather, Karen, McDonald, Colm, McMahon, Katie L., Medland, Sarah E., Menchón, José M., Morris, Derek W., Mothersill, Omar, Maniega, Susana Munoz, Mwangi, Benson, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswaamy, Janardhanan C., Nees, Frauke, Nordvik, Jan E., Onnink, A. Marten H., Opel, Nils, Ophoff, Roel, Paillère Martinot, Marie Laure, Papadopoulos Orfanos, Dimitri, Pauli, Paul, Paus, Tomáš, Poustka, Luise, Reddy, Janardhan Yc, Renteria, Miguel E., Roiz-Santiáñez, Roberto, Roos, Annerine, Royle, Natalie A., Sachdev, Perminder, Sánchez-Juan, Pascual, Schmaal, Lianne, Schumann, Gunter, Shumskaya, Elena, Smolka, Michael N., Soares, Jair C., Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Toro, Roberto, Turner, Jessica A., Tzourio-Mazoyer, Nathalie, Uhlmann, Anne, Hernández, Maria Valdés, van den Heuvel, Odile A., van der Meer, Dennis, van Haren, Neeltje E.M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vetter, Nora C., Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wang, Zhen, Wardlaw, Joanna, Wen, Wei, Westlye, Lars T., Whelan, Robert, Wittfeld, Katharina, Wolfers, Thomas, Wright, Margaret J., Xu, Jian, Xu, Xiufeng, Yun, Je Yeon, Zhao, Jing Jing, Franke, Barbara, Thompson, Paul M., Glahn, David C., Mazoyer, Bernard, Fisher, Simon E., and Francks, Clyde
- Published
- 2017
354. Mouse and human genetic analyses associate Kalirin with ventral striatal activation during impulsivity and with alcohol misuse
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Carvalho, Fabiana M., Sanchez-Roige, Sandra, Quinlan, Erin Burke, Jia, Tianye, Walker-Tilley, Tom, Rulten, Stuart L., Pearl, Frances M. G., Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Conrod, Patricia J., Flor, Herta, Garavan, Hugh, Heinz, Andreas, Gowland, Penny A., Paillere Martinot, Marie-Laure, Rietschel, Marcella, Robbins, Trevor W., Smolka, Michael N., Schumann, Gunter, and Stephens, David N.
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impulsivity, binge drinking, adolescent, fMRI, BXD recombinant inbred strains, monetary incentive delay, 5-choice serial reaction time task - Abstract
Impulsivity is associated with a spectrum of psychiatric disorders including drug addiction. To investigate genetic associations with impulsivity and initiation of drug taking, we took a two-step approach. First, we identified genes whose expression level in prefrontal cortex, striatum and accumbens were associated with impulsive behavior in the 5-choice serial reaction time task across 10 BXD recombinant inbred (BXD RI) mouse strains and their progenitor C57BL/6J and DBA2/J strains. Behavioral data were correlated with regional gene expression using GeneNetwork (www.genenetwork.org), to identify 44 genes whose probability of association with impulsivity exceeded a false discovery rate of < 0.05. We then interrogated the IMAGEN database of 1423 adolescents for potential associations of SNPs in human homologs of those genes identified in the mouse study, with brain activation during impulsive performance in the Monetary Incentive Delay task, and with novelty seeking scores from the Temperament and Character Inventory, as well as alcohol experience. There was a significant overall association between the human homologs of impulsivity-related genes and percentage of premature responses in the MID task and with fMRI BOLD-response in ventral striatum (VS) during reward anticipation. In contrast, no significant association was found between the polygenic scores and anterior cingulate cortex activation. Univariate association analyses revealed that the G allele (major) of the intronic SNP rs6438839 in the KALRN gene was significantly associated with increased VS activation. Additionally, the A-allele (minor) of KALRN intronic SNP rs4634050, belonging to the same haplotype block, was associated with increased frequency of binge drinking.
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- 2016
355. A randomized controlled clinical trial of real-time functional magnetic resonance imaging neurofeedback for adolescents with attention deficit hyperactivity disorder (ADHD)
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Alegria Analucia, Rubia Katya, David Anthony, Brandeis Daniel, Stahl Daniel, Giampietro Vincent, Barker Gareth, Wulff Melanie, and Brinson Helen
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Clinical trial ,Behavioral Neuroscience ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,Physical medicine and rehabilitation ,Neurology ,medicine ,Attention deficit hyperactivity disorder ,Neurofeedback ,business ,Functional magnetic resonance imaging ,Biological Psychiatry - Published
- 2016
356. The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder
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Mallas, Emma-Jane, Carletti, Francesco, Chaddock, Christopher A, Shergill, Sukhi, Woolley, James, Picchioni, Marco M, McDonald, Colm, Toulopoulou, Timothea, Kravariti, Eugenia, Kalidindi, Sridevi, Bramon, Elvira, Murray, Robin, Barker, Gareth J, and Prata, Diana
- Abstract
Genome-wide studies have identified allele A (adenine) of single nucleotide polymorphism (SNP) rs1006737 of the calcium-channel CACNA1C gene as a risk factor for both schizophrenia (SZ) and bipolar disorder (BD) as well as allele A for rs1344706 in the zinc-finger ZNF804A gene. These illnesses have also been associated with white matter abnormalities, reflected by reductions in fractional anisotropy (FA), measured using diffusion tensor imaging (DTI). We assessed the impact of the CACNA1C psychosis risk variant on FA in SZ, BD and health. 230 individuals (with existing ZNF804A rs1344706 genotype data) were genotyped for CACNA1C rs1006737 and underwent DTI. FA data was analysed with tract-based spatial statistics and threshold-free cluster enhancement significance correction (p
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- 2016
357. White Matter Connectivity of the Thalamus Delineates the Functional Architecture of Competing Thalamocortical Systems
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O'Muircheartaigh, Jonathan, Keller, Simon S, Barker, Gareth J, and Richardson, Mark P
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There is an increasing awareness of the involvement of thalamic connectivity on higher level cortical functioning in the human brain. This is reflected by the influence of thalamic stimulation on cortical activity and behavior as well as apparently cortical lesion syndromes occurring as a function of small thalamic insults. Here, we attempt to noninvasively test the correspondence of structural and functional connectivity of the human thalamus using diffusion-weighted and resting-state functional MRI. Using a large sample of 102 adults, we apply tensor independent component analysis to diffusion MRI tractography data to blindly parcellate bilateral thalamus according to diffusion tractography-defined structural connectivity. Using resting-state functional MRI collected in the same subjects, we show that the resulting structurally defined thalamic regions map to spatially distinct, and anatomically predictable, whole-brain functional networks in the same subjects. Although there was significant variability in the functional connectivity patterns, the resulting 51 structural and functional patterns could broadly be reduced to a subset of 7 similar core network types. These networks were distinct from typical cortical resting-state networks. Importantly, these networks were distributed across the brain and, in a subset, map extremely well to known thalamocortico-basal-ganglial loops.
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- 2015
358. The IMAGEN study: a decade of imaging genetics in adolescents
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Mascarell Maričić, Lea, Walter, Henrik, Rosenthal, Annika, Ripke, Stephan, Quinlan, Erin Burke, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Itterman, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Smolka, Michael N., Fröhner, Juliane H., Whelan, Robert, Kaminski, Jakob, Schumann, Gunter, and Heinz, Andreas
- Abstract
Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype ‘drug use’ to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions.
- Published
- 2020
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359. Distinct brain structure and behavior related to ADHD and conduct disorder traits
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Bayard, Frida, Nymberg Thunell, Charlotte, Abé, Christoph, Almeida, Rita, Banaschewski, Tobias, Barker, Gareth, Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Conrod, Patricia, Stringaris, Argyris, Struve, Maren, Penttilä, Jani, Kappel, Viola, Grimmer, Yvonne, Fadai, Tahmine, van Noort, Betteke, Smolka, Michael N., Vetter, Nora C., Walter, Henrik, Whelan, Robert, Schumann, Gunter, and Petrovic, Predrag
- Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) and conduct disorder (CD) exemplify top-down dysregulation conditions that show a large comorbidity and shared genetics. At the same time, they entail two different types of symptomology involving mainly non-emotional or emotional dysregulation. Few studies have tried to separate the specific biology underlying these two dimensions. It has also been suggested that both types of conditions consist of extreme cases in the general population where the symptoms are widely distributed. Here we test whether brain structure is specifically associated to ADHD or CD symptoms in a general population of adolescents (n?=?1093) being part of the IMAGEN project. Both ADHD symptoms and CD symptoms were related to similar and overlapping MRI findings of a smaller structure in prefrontal and anterior cingulate cortex. However, our regions of interest (ROI) approach indicated that gray matter volume (GMV) and surface area (SA) in dorsolateral/dorsomedial prefrontal cortex and caudal anterior cingulate cortex were negatively associated to ADHD symptoms when controlling for CD symptoms while rostral anterior cingulate cortex GMV was negatively associated to CD symptoms when controlling for ADHD symptoms. The structural findings were mirrored in performance of neuropsychological tests dependent on prefrontal and anterior cingulate regions, showing that while performance on the Stop Signal test was specifically related to the ADHD trait, delayed discounting and working memory were related to both ADHD and CD traits. These results point towards a partially domain specific and dimensional capacity in different top-down regulatory systems associated with ADHD and CD symptoms.
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- 2020
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360. Improving fMRI in signal drop-out regions at 7 T by using tailored radio-frequency pulses: application to the ventral occipito-temporal cortex
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Rua, Catarina, primary, Wastling, Stephen J., additional, Costagli, Mauro, additional, Symms, Mark R., additional, Biagi, Laura, additional, Cosottini, Mirco, additional, Del Guerra, Alberto, additional, Tosetti, Michela, additional, and Barker, Gareth J., additional
- Published
- 2017
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361. Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior
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Mackey, Scott, primary, Chaarani, Bader, additional, Kan, Kees-Jan, additional, Spechler, Philip A., additional, Orr, Catherine, additional, Banaschewski, Tobias, additional, Barker, Gareth, additional, Bokde, Arun L.W., additional, Bromberg, Uli, additional, Büchel, Christian, additional, Cattrell, Anna, additional, Conrod, Patricia J., additional, Desrivières, Sylvane, additional, Flor, Herta, additional, Frouin, Vincent, additional, Gallinat, Jürgen, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Paillère Martinot, Marie-Laure, additional, Artiges, Eric, additional, Nees, Frauke, additional, Papadopoulos-Orfanos, Dimitri, additional, Poustka, Luise, additional, Smolka, Michael N., additional, Jurk, Sarah, additional, Walter, Henrik, additional, Whelan, Robert, additional, Schumann, Gunter, additional, Althoff, Robert R., additional, and Garavan, Hugh, additional
- Published
- 2017
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362. Impact of a Common Genetic Variation Associated With Putamen Volume on Neural Mechanisms of Attention-Deficit/Hyperactivity Disorder
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Xu, Bing, primary, Jia, Tianye, additional, Macare, Christine, additional, Banaschewski, Tobias, additional, Bokde, Arun L.W., additional, Bromberg, Uli, additional, Büchel, Christian, additional, Cattrell, Anna, additional, Conrod, Patricia J., additional, Flor, Herta, additional, Frouin, Vincent, additional, Gallinat, Jürgen, additional, Garavan, Hugh, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Martinot, Jean-Luc, additional, Paillère Martinot, Marie-Laure, additional, Nees, Frauke, additional, Orfanos, Dimitri Papadopoulos, additional, Paus, Tomáš, additional, Poustka, Luise, additional, Smolka, Michael N., additional, Walter, Henrik, additional, Whelan, Robert, additional, Schumann, Gunter, additional, Desrivières, Sylvane, additional, Barker, Gareth, additional, Quinlan, Erin Burke, additional, Artiges, Eric, additional, Lemaitre, Herve, additional, Vetter, Nora C., additional, Jurk, Sarah, additional, and Mennigen, Eva, additional
- Published
- 2017
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363. Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes
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McGinnity, Colm J., primary, Smith, Anna B., additional, Yaakub, Siti N., additional, Weidenbach Gerbase, Sofia, additional, Gammerman, Anya, additional, Tyson, Adam L., additional, Bell, Tiffany K., additional, Elmasri, Marwa, additional, Barker, Gareth J., additional, Richardson, Mark P., additional, and Pal, Deb K., additional
- Published
- 2017
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364. Real‐time fMRI neurofeedback in adolescents with attention deficit hyperactivity disorder
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Alegria, Analucia A., primary, Wulff, Melanie, additional, Brinson, Helen, additional, Barker, Gareth J., additional, Norman, Luke J., additional, Brandeis, Daniel, additional, Stahl, Daniel, additional, David, Anthony S., additional, Taylor, Eric, additional, Giampietro, Vincent, additional, and Rubia, Katya, additional
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- 2017
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365. Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory
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Scott, Hannah, primary, Smith, Anna E., additional, Barker, Gareth R., additional, Uney, James B., additional, and Warburton, E. Clea, additional
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- 2017
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366. SA83. Brain Glutamate Levels and Antipsychotic Response in Schizophrenia
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Egerton, Alice, primary, Merritt, Kate, additional, McQueen, Grant, additional, Howes, Oliver, additional, Demjaha, Arsime, additional, Brugger, Stefan, additional, Barker, Gareth, additional, Stone, James, additional, Dazzan, Paola, additional, Broberg, Brian, additional, van Haren, Neeltje, additional, Glenthoj, Birte, additional, Kahn, René, additional, and McGuire, Philip, additional
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- 2017
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367. 195. Relationship Between Prefrontal Glutamate Levels and Functional Activation During Emotional Processing in Individuals With High Schizotypy
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Modinos, Gemma, primary, McLaughlin, Anna, additional, Egerton, Alice, additional, McMullen, Katrina, additional, Kumari, Veena, additional, Barker, Gareth J, additional, Keysers, Christian, additional, and Williams, Steven CR, additional
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- 2017
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368. Separate elements of episodic memory subserved by distinct hippocampal–prefrontal connections
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Barker, Gareth R I, primary, Banks, Paul J, additional, Scott, Hannah, additional, Ralph, G Scott, additional, Mitrophanous, Kyriacos A, additional, Wong, Liang-Fong, additional, Bashir, Zafar I, additional, Uney, James B, additional, and Warburton, E Clea, additional
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- 2017
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369. Cervical cord myelin water imaging shows degenerative changes over one year in multiple sclerosis but not neuromyelitis optica spectrum disorder
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Combes, Anna J.E., primary, Matthews, Lucy, additional, Lee, Jimmy S., additional, Li, David K.B., additional, Carruthers, Robert, additional, Traboulsee, Anthony L., additional, Barker, Gareth J., additional, Palace, Jacqueline, additional, and Kolind, Shannon, additional
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- 2017
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370. Nonlinear functional mapping of the human brain
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Allgaier, Nicholas, Banaschewski, Tobias, Barker, Gareth, Bokde, Arun L. W., Bongard, Josh C., Bromberg, Uli, B��chel, Christian, Cattrell, Anna, Conrod, Patricia J., Danforth, Christopher M., Desrivi��res, Sylvane, Dodds, Peter S., Flor, Herta, Frouin, Vincent, Gallinat, J��rgen, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Mackey, Scott, Martinot, Jean-Luc, Murphy, Kevin, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Poustka, Luise, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Garavan, Hugh, and Consortium, IMAGEN
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FOS: Computer and information sciences ,FOS: Biological sciences ,Quantitative Biology - Neurons and Cognition ,Computer Science - Neural and Evolutionary Computing ,Neurons and Cognition (q-bio.NC) ,Neural and Evolutionary Computing (cs.NE) - Abstract
The field of neuroimaging has truly become data rich, and novel analytical methods capable of gleaning meaningful information from large stores of imaging data are in high demand. Those methods that might also be applicable on the level of individual subjects, and thus potentially useful clinically, are of special interest. In the present study, we introduce just such a method, called nonlinear functional mapping (NFM), and demonstrate its application in the analysis of resting state fMRI from a 242-subject subset of the IMAGEN project, a European study of adolescents that includes longitudinal phenotypic, behavioral, genetic, and neuroimaging data. NFM employs a computational technique inspired by biological evolution to discover and mathematically characterize interactions among ROI (regions of interest), without making linear or univariate assumptions. We show that statistics of the resulting interaction relationships comport with recent independent work, constituting a preliminary cross-validation. Furthermore, nonlinear terms are ubiquitous in the models generated by NFM, suggesting that some of the interactions characterized here are not discoverable by standard linear methods of analysis. We discuss one such nonlinear interaction in the context of a direct comparison with a procedure involving pairwise correlation, designed to be an analogous linear version of functional mapping. We find another such interaction that suggests a novel distinction in brain function between drinking and non-drinking adolescents: a tighter coupling of ROI associated with emotion, reward, and interoceptive processes such as thirst, among drinkers. Finally, we outline many improvements and extensions of the methodology to reduce computational expense, complement other analytical tools like graph-theoretic analysis, and allow for voxel level NFM to eliminate the necessity of ROI selection., 21 pages, 12 figures, and 1 table
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- 2015
371. Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission:NMDARs control hippocampal-PFC synaptic transmission
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Banks, Paul, Burroughs, Amelia, Barker, Gareth, Brown, Jon T, Warburton, Clea, and Bashir, Zafar
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schizophrenia ,nervous system ,NMDA receptor hypofunction ,mental disorders ,long - term depression ,medial prefrontal cortex ,D2R - Abstract
Functional connectivity between the hippocampus and prefrontal cortex (PFC) is essential for associative recognition memory and working memory. Disruption of hippocampal–PFC synchrony occurs in schizophrenia, which is characterized by hypofunction of NMDA receptor (NMDAR)-mediated transmission. We demonstrate that activity of dopamine D2-like receptors (D2Rs) leads selectively to long-term depression (LTD) of hippocampal–PFC NMDAR-mediated synaptic transmission. We show that dopamine-dependent LTD of NMDAR-mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia.
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- 2015
372. Cortical and subcortical glutathione levels in adults with autism spectrum disorder
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Durieux, Alice M. S., Horder, Jamie, Hernandez, M. Andreina, Egerton, Alice, Williams, Steven C. R., Wilson, C. Ellie, Spain, Deborah, Murphy, Clodagh, Robertson, Dene, Barker, Gareth John, Murphy, Declan G, and McAlonan, Grainne M
- Abstract
Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men.
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- 2015
373. Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy
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Keller, Simon S., primary, Glenn, G. Russell, additional, Weber, Bernd, additional, Kreilkamp, Barbara A. K., additional, Jensen, Jens H., additional, Helpern, Joseph A., additional, Wagner, Jan, additional, Barker, Gareth J., additional, Richardson, Mark P., additional, and Bonilha, Leonardo, additional
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- 2016
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374. Correlated gene expression supports synchronous activity in brain networks
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Richiardi, J., Altmann, A., Milazzo, A.-C., Chang, C., Chakravarty, M. M., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Buchel, C., Conrod, P., Fauth-Buhler, M., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Lemaitre, H., Mann, K. F., Martinot, J.-L., Nees, F., Paus, T., Pausova, Z., Rietschel, M., Robbins, T. W., Smolka, M. N., Spanagel, R., Strohle, A., Schumann, G., Hawrylycz, M., Poline, J.-B., Greicius, M. D., Albrecht, L., Andrew, C., Arroyo, M., Artiges, E., Aydin, S., Bach, C., Barbot, A., Barker, Gareth, Boddaert, N., Bokde, A., Bricaud, Z., Bruehl, R., Cachia, A., Cattrell, A., Constant, P., Dalley, J., Decideur, B., Desrivieres, S., Fadai, T., Briand, F. G., Heinrichs, B., Heym, N., Hubner, T., Ireland, J., Ittermann, B., Jia, T., Lathrop, M., Lanzerath, D., Lawrence, C., Ludemann, K., Macare, C., Mallik, C., Mangin, J.-F., Mann, K., Martinot, J.- L., Mennigen, E., Mesquita de Carvahlo, F., Mignon, X., Miranda, Ruben, Muller, K., Nymberg, C., Paillere, M.-L., Poustka, L., Rapp, M., Robert, G., Reuter, J., Ripke, S., Robbins, Trevor, Rodehacke, S., Rogers, J., Romanowski, A., Ruggeri, B., Schmal, C., Schmidt, D., Schneider, S., Schumann, M., Schubert, F., Schwartz, Y., Smolka, M., Sommer, W., Speiser, C., Spranger, T., Stedman, A., Steiner, S., Stephens, D., Strache, N., Struve, M., Subramaniam, N., Topper, L., Whelan, R., Williams, S., Yacubian, J., Zilbovicius, M., Wong, C. P., Lubbe, S., Martinez-Medina, L., Fernandes, A., Tahmasebi, A., and IMAGEN consortium
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Multidisciplinary - Published
- 2015
375. Common genetic variants influence human subcortical brain structures
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Hibar, Derrek P, Stein, Jason L, Aribisala, Benjamin S, de Zubicaray, Greig I, Dillman, Allissa, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Fedko, Iryna O, Ferrucci, Luigi, Foroud, Tatiana M, Fox, Peter T, Fukunaga, Masaki, Armstrong, Nicola J, Gibbs, J Raphael, Göring, Harald H H, Green, Robert C, Guelfi, Sebastian, Hansell, Narelle K, Hartman, Catharina A, Hegenscheid, Katrin, Heinz, Andreas, Hernandez, Dena G, Heslenfeld, Dirk J, Bernard, Manon, Hoekstra, Pieter J, Holsboer, Florian, Homuth, Georg, Hottenga, Jouke-Jan, Ikeda, Masashi, Jack, Clifford R, Jenkinson, Mark, Johnson, Robert, Kanai, Ryota, Keil, Maria, Bohlken, Marc M, Kent, Jack W, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Liu, Xinmin, Longo, Dan L, McMahon, Katie L, Meisenzahl, Eva, Melle, Ingrid, Mohnke, Sebastian, Boks, Marco P, Montgomery, Grant W, Mostert, Jeanette C, Mühleisen, Thomas W, Nalls, Michael A, Nichols, Thomas E, Nilsson, Lars G, Nöthen, Markus M, Ohi, Kazutaka, Olvera, Rene L, Perez-Iglesias, Rocio, Bralten, Janita, Pike, G Bruce, Potkin, Steven G, Reinvang, Ivar, Reppermund, Simone, Rietschel, Marcella, Romanczuk-Seiferth, Nina, Rosen, Glenn D, Rujescu, Dan, Schnell, Knut, Schofield, Peter R, Brown, Andrew A, Smith, Colin, Steen, Vidar M, Sussmann, Jessika E, Thalamuthu, Anbupalam, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Valdés Hernández, Maria C, van 't Ent, Dennis, Chakravarty, M Mallar, van der Brug, Marcel, van der Wee, Nic J A, van Tol, Marie-Jose, Veltman, Dick J, Wassink, Thomas H, Westman, Eric, Zielke, Ronald H, Zonderman, Alan B, Ashbrook, David G, Hager, Reinmar, Chen, Qiang, Lu, Lu, McMahon, Francis J, Morris, Derek W, Williams, Robert W, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Cahn, Wiepke, Calhoun, Vince D, Cavalleri, Gianpiero L, Ching, Christopher R K, Crespo-Facorro, Benedicto, Dale, Anders M, Davies, Gareth E, Delanty, Norman, Depondt, Chantal, Djurovic, Srdjan, Drevets, Wayne C, Espeseth, Thomas, Gollub, Randy L, Ho, Beng-Choon, Renteria, Miguel E, Cuellar-Partida, Gabriel, Hoffmann, Wolfgang, Hosten, Norbert, Kahn, René S, Le Hellard, Stephanie, Meyer-Lindenberg, Andreas, Müller-Myhsok, Bertram, Nauck, Matthias, Nyberg, Lars, Pandolfo, Massimo, Penninx, Brenda W J H, den Braber, Anouk, Roffman, Joshua L, Sisodiya, Sanjay M, Smoller, Jordan W, van Bokhoven, Hans, van Haren, Neeltje E M, Völzke, Henry, Walter, Henrik, Weiner, Michael W, Wen, Wei, White, Tonya, Giddaluru, Sudheer, Agartz, Ingrid, Andreassen, Ole A, Blangero, John, Boomsma, Dorret I, Brouwer, Rachel M, Cannon, Dara M, Cookson, Mark R, de Geus, Eco J C, Deary, Ian J, Donohoe, Gary, Goldman, Aaron L, Fernández, Guillén, Fisher, Simon E, Francks, Clyde, Glahn, David C, Grabe, Hans J, Gruber, Oliver, Hardy, John, Hashimoto, Ryota, Hulshoff Pol, Hilleke E, Jönsson, Erik G, Grimm, Oliver, Kloszewska, Iwona, Lovestone, Simon, Mattay, Venkata S, Mecocci, Patrizia, McDonald, Colm, McIntosh, Andrew M, Ophoff, Roel A, Paus, Tomas, Pausova, Zdenka, Ryten, Mina, Guadalupe, Tulio, Sachdev, Perminder S, Saykin, Andrew J, Simmons, Andy, Singleton, Andrew, Soininen, Hilkka, Wardlaw, Joanna M, Weale, Michael E, Weinberger, Daniel R, Adams, Hieab H H, Launer, Lenore J, Hass, Johanna, Seiler, Stephan, Schmidt, Reinhold, Chauhan, Ganesh, Satizabal, Claudia L, Becker, James T, Yanek, Lisa, van der Lee, Sven J, Ebling, Maritza, Fischl, Bruce, Longstreth, W. T., Woldehawariat, Girma, Greve, Douglas, Schmidt, Helena, Nyquist, Paul, Vinke, Louis N, van Duijn, Cornelia M, Xue, Luting, Mazoyer, Bernard, Bis, Joshua C, Gudnason, Vilmundur, Seshadri, Sudha, Holmes, Avram J, Ikram, M Arfan, Initiative, Alzheimer’s Disease Neuroimaging, Consortium, CHARGE, EPIGEN, IMAGEN, SYS, Martin, Nicholas G, Wright, Margaret J, Schumann, Gunter, Franke, Barbara, Hoogman, Martine, Thompson, Paul M, Medland, Sarah E, Weiner, Michael, Aisen, Paul, Petersen, Ronald, Jagust, William, Trojanowki, John Q, Beckett, Laurel, Arias-Vasquez, Alejandro, Janowitz, Deborah, Morris, John, Shaw, Leslie M, Khachaturian, Zaven, Sorensen, Greg, Carrillo, Maria, Kuller, Lew, Raichle, Marc, Paul, Steven, Jia, Tianye, Davies, Peter, Fillit, Howard, Hefti, Franz, Holtzman, Davie, Mesulman, M Marcel, Potter, William, Snyder, Peter, Schwartz, Adam, Montine, Tom, Kim, Sungeun, Thomas, Ronald G, Donohue, Michael, Walter, Sarah, Gessert, Devon, Sather, Tamie, Jiminez, Gus, Harvey, Danielle, Klein, Marieke, Bernstein, Matthew, Fox, Nick, Thompson, Paul, Schuff, Norbert, DeCarli, Charles, Borowski, Bret, Gunter, Jeff, Senjem, Matt, Kraemer, Bernd, Vemuri, Prashanthi, Jones, David, Kantarci, Kejal, Ward, Chad, Koeppe, Robert A, Foster, Norm, Reiman, Eric M, Chen, Kewei, Mathis, Chet, Lee, Phil H, Landau, Susan, Cairns, Nigel J, Householder, Erin, Taylor-Reinwald, Lisa, Trojanowki, J. Q., Shaw, Les, Lee, Virginia M Y, Korecka, Magdalena, Figurski, Michal, Olde Loohuis, Loes M, Crawford, Karen, Neu, Scott, Potkin, Steven, Shen, Li, Faber, Kelley, Nho, Kwangsik, Luciano, Michelle, Thal, Leon, Frank, Richard, Snyder, Peter J, Buckholtz, Neil, Macare, Christine, Albert, Marilyn, Hsiao, John, Kaye, Jeffrey, Quinn, Joseph, Lind, Betty, Carter, Raina, Dolen, Sara, Gutman, Boris A, Schneider, Lon S, Mather, Karen A, Pawluczyk, Sonia, Beccera, Mauricio, Teodoro, Liberty, Spann, Bryan M, Brewer, James, Vanderswag, Helen, Fleisher, Adam, Heidebrink, Judith L, Lord, Joanne L, Desrivières, Sylvane, Mattheisen, Manuel, Mason, Sara S, Albers, Colleen S, Knopman, David, Johnson, Kris, Doody, Rachelle S, Villanueva-Meyer, Javier, Chowdhury, Munir, Rountree, Susan, Dang, Mimi, Stern, Yaakov, Milaneschi, Yuri, Honig, Lawrence S, Bell, Karen L, Ances, Beau, Morris, John C, Carroll, Maria, Leon, Sue, Mintun, Mark A, Schneider, Stacy, Oliver, Angela, Marson, Daniel, Griffith, Randall, Clark, David, Geldmacher, David, Brockington, John, Roberson, Erik, Grossman, Hillel, Mitsis, Effie, deToledo-Morrell, Leyla, Shah, Raj C, Papmeyer, Martina, Duara, Ranjan, Varon, Daniel, Greig, Maria T, Roberts, Peggy, Onyike, Chiadi, D'Agostino, Daniel, Kielb, Stephanie, Galvin, James E, Pogorelec, Dana M, Ramasamy, Adaikalavan, Cerbone, Brittany, Michel, Christina A, Rusinek, Henry, de Leon, Mony J, Glodzik, Lidia, De Santi, Susan, Doraiswamy, P Murali, Petrella, Jeffrey R, Wong, Terence Z, Arnold, Steven E, Risacher, Shannon L, Karlawish, Jason H, Wolk, David, Smith, Charles D, Jicha, Greg, Hardy, Peter, Sinha, Partha, Oates, Elizabeth, Conrad, Gary, Lopez, Oscar L, Oakley, MaryAnn, Roiz-Santiañez, Roberto, Simpson, Donna M, Porsteinsson, Anton P, Goldstein, Bonnie S, Martin, Kim, Makino, Kelly M, Ismail, M Saleem, Brand, Connie, Mulnard, Ruth A, Thai, Gaby, Mc-Adams-Ortiz, Catherine, Rose, Emma J, Womack, Kyle, Mathews, Dana, Quiceno, Mary, Diaz-Arrastia, Ramon, King, Richard, Weiner, Myron, Martin-Cook, Kristen, DeVous, Michael, Levey, Allan I, Lah, James J, Salami, Alireza, Cellar, Janet S, Burns, Jeffrey M, Anderson, Heather S, Swerdlow, Russell H, Apostolova, Liana, Tingus, Kathleen, Woo, Ellen, Silverman, Daniel H S, Lu, Po H, Bartzokis, George, Sämann, Philipp G, Graff-Radford, Neill R, Parfitt, Francine, Kendall, Tracy, Johnson, Heather, Farlow, Martin R, Hake, Ann Marie, Matthews, Brandy R, Herring, Scott, Hunt, Cynthia, van Dyck, Christopher H, Jahanshad, Neda, Schmaal, Lianne, Carson, Richard E, MacAvoy, Martha G, Chertkow, Howard, Bergman, Howard, Hosein, Chris, Black, Sandra, Stefanovic, Bojana, Caldwell, Curtis, Hsiung, Yuek Robin, Feldman, Howard, Schork, Andrew J, Mudge, Benita, Assaly, Michele, Kertesz, Andrew, Rogers, John, Trost, Dick, Bernick, Charles, Munic, Donna, Kerwin, Diana, Mesulam, Marek-Marsel, Lipowski, Kristine, Shin, Jean, Wu, Chuang-Kuo, Johnson, Nancy, Sadowsky, Carl, Martinez, Walter, Villena, Teresa, Turner, Raymond Scott, Johnson, Kathleen, Reynolds, Brigid, Sperling, Reisa A, Johnson, Keith A, Strike, Lachlan T, Marshall, Gad, Frey, Meghan, Yesavage, Jerome, Taylor, Joy L, Lane, Barton, Rosen, Allyson, Tinklenberg, Jared, Sabbagh, Marwan N, Belden, Christine M, Jacobson, Sandra A, Teumer, Alexander, Sirrel, Sherye A, Kowall, Neil, Killiany, Ronald, Budson, Andrew E, Norbash, Alexander, Johnson, Patricia Lynn, Obisesan, Thomas O, Wolday, Saba, Allard, Joanne, Lerner, Alan, van Donkelaar, Marjolein M J, Ogrocki, Paula, Hudson, Leon, Fletcher, Evan, Carmichael, Owen, Olichney, John, Kittur, Smita, Borrie, Michael, Lee, T-Y, Bartha, Rob, van Eijk, Kristel R, Johnson, Sterling, Asthana, Sanjay, Carlsson, Cynthia M, Preda, Adrian, Nguyen, Dana, Tariot, Pierre, Reeder, Stephanie, Bates, Vernice, Walters, Raymond K, Capote, Horacio, Rainka, Michelle, Scharre, Douglas W, Kataki, Maria, Adeli, Anahita, Zimmerman, Earl A, Celmins, Dzintra, Brown, Alice D, Pearlson, Godfrey D, Blank, Karen, Westlye, Lars T, Anderson, Karen, Santulli, Robert B, Kitzmiller, Tamar J, Schwartz, Eben S, Sink, Kaycee M, Williamson, Jeff D, Garg, Pradeep, Watkins, Franklin, Ott, Brian R, Querfurth, Henry, Whelan, Christopher D, Tremont, Geoffrey, Salloway, Stephen, Malloy, Paul, Correia, Stephen, Rosen, Howard J, Miller, Bruce L, Mintzer, Jacobo, Spicer, Kenneth, Bachman, David, Finger, Elizabether, Toro, Roberto, Winkler, Anderson M, Pasternak, Stephen, Rachinsky, Irina, Drost, Dick, Pomara, Nunzio, Hernando, Raymundo, Sarrael, Antero, Schultz, Susan K, Ponto, Laura L Boles, Zwiers, Marcel P, Shim, Hyungsub, Smith, Karen Elizabeth, Relkin, Norman, Chaing, Gloria, Raudin, Lisa, Smith, Amanda, Fargher, Kristin, Raj, Balebail Ashok, Amin, Najaf, Becker, Diane, Alhusaini, Saud, Beiser, Alexa, Debette, Stéphanie, DeStefano, Anita, Hofer, Edith, Hofman, Albert, Niessen, Wiro J, Smith, Albert, Tzourio, Christophe, Vaidya, Dhananjay, Athanasiu, Lavinia, Vernooij, Meike W, Goldstein, David B, Heinzen, Erin L, Shianna, Kevin, Radtke, Rodney, Ottmann, Ruth, Albrecht, Lisa, Andrew, Chris, Arroyo, Mercedes, Artiges, Eric, Ehrlich, Stefan, Aydin, Semiha, Bach, Christine, Banaschewski, Tobias, Barbot, Alexis, Barker, Gareth, Boddaert, Nathalie, Bokde, Arun, Bricaud, Zuleima, Bromberg, Uli, Bruehl, Ruediger, Hakobjan, Marina M H, Büchel, Christian, Cachia, Arnaud, Cattrell, Anna, Conrod, Patricia, Constant, Patrick, Crombag, Hans, Czech, Katharina, Dalley, Jeffrey, Decideur, Benjamin, Desrivieres, Sylvane, Hartberg, Cecilie B, Fadai, Tahmine, Flor, Herta, Frouin, Vincent, Fuchs, Birgit, Gallinat, Jürgen, Garavan, Hugh, Briand, Fanny Gollier, Gowland, Penny, Head, Kay, Heinrichs, Bert, Haukvik, Unn K, Heym, Nadja, Hübner, Thomas, Ihlenfeld, Albrecht, Ireland, James, Ittermann, Bernd, Ivanov, Nikolay, Jones, Jennifer, Klaassen, Arno, Heister, Angelien J G A M, Lalanne, Christophe, Lathrop, Mark, Lanzerath, Dirk, Lemaitre, Hervé, Lüdemann, Katharina, Mallik, Catherine, Mangin, Jean-François, Mann, Karl, Mar, Adam, Hoehn, David, Martinot, Jean-Luc, Massicotte, Jessica, Mennigen, Eva, Mesquita de Carvahlo, Fabiana, Mignon, Xavier, Miranda, Ruben, Müller, Kathrin, Nees, Frauke, Nymberg, Charlotte, Paillere, Marie-Laure, Wittfeld, Katharina, Kasperaviciute, Dalia, Pena-Oliver, Yolanda, Poline, Jean-Baptiste, Poustka, Luise, Rapp, Michael, Reed, Laurence, Robert, Gabriel, Reuter, Jan, Liewald, David C M, Ripke, Stephan, Ripley, Tamzin, Robbins, Trevor, Rodehacke, Sarah, Romanowski, Alexander, Ruggeri, Barbara, Schilling, Christina, Schmäl, Christine, Schmidt, Dirk, Lopez, Lorna M, Schneider, Sophia, Schroeder, Markus, Schubert, Florian, Schwartz, Yannick, Smolka, Michael, Sommer, Wolfgang, Spanagel, Rainer, Speiser, Claudia, Spranger, Tade, Stedman, Alicia, Makkinje, Remco R R, Steiner, Sabina, Stephens, Dai, Strache, Nicole, Ströhle, Andreas, Struve, Maren, Subramaniam, Naresh, Theobald, David, Topper, Lauren, Vollstaedt-Klein, Sabine, Walaszek, Bernadeta, Matarin, Mar, Weiß, Katharina, Werts, Helen, Whelan, Robert, Williams, Steve, Yacubian, Juliana, Ziesch, Veronika, Zilbovicius, Monica, Wong, C Peng, Lubbe, Steven, Naber, Marlies A M, Martinez-Medina, Lourdes, Kepa, Agnes, Fernandes, Alinda, Tahmasebi, Amir, Abrahamowicz, Michal, Gaudet, Daniel, Leonard, Gabriel, Perron, Michel, Richer, Louis, Seguin, Jean, McKay, D Reese, Veillette, Suzanne, Needham, Margaret, Nugent, Allison C, Pütz, Benno, Abramovic, Lucija, Royle, Natalie A, Sprooten, Emma, Trabzuni, Daniah, van der Marel, Saskia S L, van Hulzen, Kimm J E, Walton, Esther, Wolf, Christiane, Almasy, Laura, Ames, David, Andersson, Micael, Arepalli, Sampath, Assareh, Amelia A, Bastin, Mark E, Brodaty, Henry, Bulayeva, Kazima B, Carless, Melanie A, Cichon, Sven, Corvin, Aiden, Curran, Joanne E, Czisch, Michael, MUMC+: DA Klinische Genetica (5), RS: GROW - Developmental Biology, RS: GROW - R4 - Reproductive and Perinatal Medicine, Université de Montréal. Faculté de médecine. Département de psychiatrie et d'addictologie, David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), QIMR Berghofer Medical Research Institute, Department of Psychiatry, Donders Centre for Neuroscience, Radboud University [Nijmegen]-Radboud University Medical Center [Nijmegen]-Radboud University [Nijmegen]-Radboud University Medical Center [Nijmegen], Department of Human Genetics, Radboud University Medical Center [Nijmegen], Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, PRES Sorbonne Paris Cité, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Gènes, Synapses et Cognition (CNRS - UMR3571 ), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Greifswald University Hospital, University Medical Center [Utrecht], European Commission, University of Edinburgh, Lagos State University (LASU), Heriot-Watt University [Edinburgh] (HWU), Unité d'expérimentation sur les Ruminants de Theix, Institut National de la Recherche Agronomique (INRA), Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], University of Oslo (UiO), Montreal Neurological Institute and Hospital, McGill University = Université McGill [Montréal, Canada], School of Technical Physics, Xidian University, Dept. of Mechanical Engineering, McMaster University [Hamilton, Ontario], Biological Psychology, Neuroscience Campus Amsterdam & EMGO Institute for Health and Care Research, VU University & VU Medical Center, Amsterdam 1081 BT, The Netherlands, Haukeland University Hospital, University of Bergen (UiB), Physicochimie des Processus de Combustion et de l’Atmosphère - UMR 8522 (PC2A), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Universität Heidelberg [Heidelberg] = Heidelberg University, Language and Genetics Department [Nijmegen], Max Planck Institute for Psycholinguistics, Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, International Max Planck Research School for Language Sciences (IMPRS ), Georgia Institute of Technology [Atlanta], National Institutes of Health [Bethesda] (NIH), Yale University [New Haven], Massachusetts General Hospital [Boston], Mental Health Sciences Unit, University College of London [London] (UCL), Beijing Normal University (BNU), Indiana University School of Medicine, Indiana University System, Indiana Alzheimer Disease Center, Indiana University System-Indiana University System, Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen 37075, Germany, Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, University of California (UC), Medstar Research Institute, Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia, Department of Genomics, Life and Brain Center, Universität Bonn = University of Bonn, Institute of Human Genetics, Department of Biomedicine and the Centre for Integrative Sequencing, Aarhus University [Aarhus], VU University Medical Center [Amsterdam], Respiratory Epidemiology and Public Health, Imperial College London-School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU)-MRC-HPA Centre for Environment and Health, Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), Institut Parisien de Chimie Moléculaire (IPCM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå 901 87, Sweden, Aging Research Center [Karolinska Institutet] (ARC ), Stockholm University-Karolinska Institutet [Stockholm], Max Planck Institute of Psychiatry, Max-Planck-Gesellschaft, Department of Neurosciences [Univ California San Diego] (Neuro - UC San Diego), School of Medicine [Univ California San Diego] (UC San Diego), University of California [San Diego] (UC San Diego), University of California (UC)-University of California (UC)-University of California [San Diego] (UC San Diego), Department of Cognitive Sciences [Univ California San Diego] (CogSci - UC San Diego), The Hospital for sick children [Toronto] (SickKids), Queensland Institute of Medical Research, School of Psychology, University of Queensland, Brisbane 4072, Australia, University of Queensland [Brisbane], Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia, Department of Genomics of Common Disease, Imperial College London, Department of Psychology [Oslo], Faculty of Social Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Deutsche Bundesbank, Department of Neurology and Neurosurgery [Montreal], McGill University = Université McGill [Montréal, Canada]-McGill University = Université McGill [Montréal, Canada], Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland (RCSI), MetaGenoPolis, Department of Psychiatric Research and Development, Diakonhjemmet Hospital, Oslo 0319, Norway, UCL Institute of Neurology and Epilepsy Society, Department of Medicine, Clinical And Experimental Epilepsy, Dpt of Psychiatry [New Haven], Yale School of Medicine [New Haven, Connecticut] (YSM), Hartford Hospital, Neuropsychiatric Genetics Research Group and Department of Psychiatry, Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 2, Ireland, Institute of Food & Health, University College Dublin, University College Dublin [Dublin] (UCD), Statistical Genetics Group, State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL, Institute of Neurology [London], Department of Genetics, King Faisal Specialist Hospital and Research Centre (KFSH & RC), Centre épigénétique et destin cellulaire (EDC), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Dundee Technopole, CXR Biosciences Ltd, Ninewells Hospital and Medical School, Biomedical Research Centre, University of Dundee, Southwest Foundation for Biomedical Research, Department of Psychiatry and National Ageing Research Institute, University of Melbourne, Department of Clinical Genetics, Department of Medical Parasitology and Mycology, School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU)-Tehran University of Medical Siences, Centre for Healthy Brain Ageing, University of New South Wales [Sydney] (UNSW), Dementia Collaborative Research Centre, N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia, Texas Biomedical Research Institute [San Antonio, TX], Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Division of Medical Genetics, University of Basel (Unibas), Trinity College Dublin-St. James's Hospital, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Department of Materials Science & Metallurgy, University of Cambridge [UK] (CAM), Bijvoet Center of Biomolecular Research [Utrecht], Utrecht University [Utrecht], School of Psychology, University of Queensland, Laboratory of Neurogenetics, The University of Texas Health Science Center at Houston (UTHealth), Department of Genomics, Department of Medical and Molecular Genetics, South Texas Veterans Health Care System, San Antonio, Texas 78229, USA, Biofunctional Imaging, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan, Public Health Genomics Unit, Department of Biomolecular Engineering, Rheinische Friedrich-Wilhelms-Universität Bonn, Estación Experimental de Pastos y Forrajes 'Indio Hatuey', University Medical Center Groningen [Groningen] (UMCG), Neuronal Plasticity / Mouse Behaviour, Interfaculty Institute for Genetics and Functional Genomics, Universität Greifswald - University of Greifswald, Department of Psychiatry, Fujita Health University School of Medicine, Toyoake 470-1192, Japan, Department of Radiology, Mayo Clinic, Department of Clinical Neurology [Oxford], University of Oxford-FMRIB Centre- John Radcliffe Hospital [Oxford University Hospital], University of Maryland School of Medicine, University of Maryland System, University of Sussex, Institute of Cognitive Neuroscience, United Kingdom Met Office [Exeter], University of Maryland [Baltimore County] (UMBC), University of Maryland System-University of Maryland System-University of Maryland School of Medicine, Department of Civil and Structural Engineering, The Hong Kong Polytechnic University [Hong Kong] (POLYU)-The Hong Kong Polytechnic University [Hong Kong] (POLYU), Columbia University Irving Medical Center (CUIMC), Lymphocyte Cell Biology Unit, Laboratory of Genetics, Centre for Advanced Imaging, Psychiatry and Psychotherapy, KG Jebsen Centre for Psychosis Research, University of Oslo (UiO)-Institute of Clinical Medicine-Oslo University Hospital [Oslo], Division of Mental Health and Addiction, Oslo University Hospital [Oslo], Institute of Clinical Medicine [Oslo], Faculty of Medicine [Oslo], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Genetic Epidemiology Unit, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Statistics [Warwick], University of Warwick [Coventry], Osaka University [Osaka], Institute of Psychiatry, King’s College London, London SE5 8AF, UK, University of Calgary, Psychiatry and Human Behavior, University of California, Irvine, California 92617, USA, University of California [Irvine] (UC Irvine), Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health [Mannheim], University Hospital Mannheim | Universitätsmedizin Mannheim-University Hospital Mannheim | Universitätsmedizin Mannheim, Space and Naval Warfare Systems Center, Klinik für Psychiatrie, Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Division of Medical Psychology, Genetics of Mental Illness and Brain Function, Neuroscience Research Australia, Développement et amélioration des plantes (UMR DAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia, Laboratory of Neuro Imaging [Los Angeles] (LONI), Departamento de Física Aplicada, Universidade de Vigo, Georgia State University, University System of Georgia (USG), Genentech, Inc. [San Francisco], Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center (LUMC), Universiteit Leiden-Universiteit Leiden, Universiteit Leiden, Carver College of Medicine [Iowa City], University of Iowa [Iowa City]-University of Iowa [Iowa City], Department of Neurobiology, Care Sciences and Society, Karolinska Institutet [Stockholm], University of Manchester [Manchester], The University of Tennessee Health Science Center [Memphis] (UTHSC), iangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong 226001, China, Centre for Ultrahigh Bandwidth Devices for Optical Systems (CUDOS), Macquarie University, Cognitive Neuroscience Laboratory (CNL), Harvard University, Donders Center for Cognitive Neuroimaging, Donders Centre for Cognitive Neuroimaging, Radboud University [Nijmegen]-Radboud University [Nijmegen], Icahn School of Medicine at Mount Sinai [New York] (MSSM), The Mind Research Network, Department of Electrical and Computer Engineering [Albuquerque] (ECE Department), The University of New Mexico [Albuquerque], Division of Molecular and Cellular Therapeutics, Scottish Association for Marine Science (SAMS), Structural Biology Laboratory, Department of Chemistry, University of York, Neurology Division, Beaumont Hospital, Dublin 9, Ireland, Beaumont Hospital, Department of Neurology, Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Deparment of Medical Genetics, Human Genetics Branch, National Institutes of Health [Bethesda] (NIH)-National Institute of Mental Health (NIMH), Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Department of Psychiatry, University of Iowa, University of Iowa [Iowa City], Institute for Community Medicine, Department Epidemiology of Health Care and Community Health, Translational Centre for Regenerative Medicine (TRM), Department of Cell Therapy, Universität Leipzig-Universität Leipzig, Institute of Clinical Chemistry and Laboratory Medicine, Department of Health Science, Division of Health and Rehabilitation, Luleå University of Technology (LUT), Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Psychiatric and Neurodevelopmental Genetics Unit, 849 Department of Human Genetics, Institute for Community Medicine, Institute for Energy Systems and Thermodynamics, Renyi Institute, Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre, Rotterdam 3000 CB, The Netherlands, Department of Radiology, Erasmus University Medical Centre, Rotterdam 3015 CN, The Netherlands, Vrije Universiteit Amsterdam [Amsterdam] (VU), Cell Biology and Gene Expression Section, National Institute of Health, Bethesda, Dept of Psychology, Laboratoire de Recherche Magellan, Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut d'Administration des Entreprises (IAE) - Lyon, Institut de Socio-économie des Entreprises et des ORganisations (ISEOR), Institut de socio-économie des entreprises et des organisations, Department of Psychiatry and Psychotherapy, HELIOS Klinikum Stralsund Hanseatic-Greifswald University Hospital, Laboratoire d'Informatique de Grenoble (LIG), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Centre for Allergy Research, Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital [Stockholm], Medical University of Łódź (MUL), Psychiatry Institute, Department of Health and Human Services, Institute of Gerontology and Geriatrics, Università degli Studi di Perugia = University of Perugia (UNIPG), Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Australian Centre for Research into Injury in Sport and its Prevention, Monash University [Clayton], University Medical Center [Utrecht]-Brain Center Rudolf Magnus, School of Psychology [Nottingham], University of Nottingham, UK (UON), McConnell Brain Imaging Centre (MNI), SickKids - The Hospital for sick children, European Centre for Medium-Range Weather Forecasts (ECMWF), University of Eastern Finland, Centre for Population Health Sciences, Lieber Institute for Brain Development [Baltimore] (LIBD), Johns Hopkins University (JHU), Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz 8010, Austria, Austrian Institute of Technology [Vienna] (AIT), INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France College of Health Sciences, University of Bordeaux, Bordeaux, France, INSERM, Neuroepidemiology U708, Bordeaux, France, Karlsruhe Institute of Technology (KIT), General Internal Medicine, Johns Hopkins School of Medicine, Johns Hopkins University School of Medicine [Baltimore], Harvard Medical School [Boston] (HMS), Computer Science and Artificial Intelligence Laboratory [Cambridge] (CSAIL), Massachusetts Institute of Technology (MIT), University of Washington [Seattle], Department of Physics [Stockholm], Stockholm University, Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands, Boston University [Boston] (BU), Groupe d'Imagerie Neurofonctionnelle (GIN - UMR 5296), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Faculty of Medicine, University of Iceland [Reykjavik], Icelandic Heart Association, Kopavogur, Iceland., Boston University School of Medicine (BUSM), Laboratoire d'Ingénierie des Matériaux de Bretagne (LIMATB), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université de Brest (UBO), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], University of California-University of California, Radboud university [Nijmegen]-Radboud University Medical Center [Nijmegen]-Radboud university [Nijmegen]-Radboud University Medical Center [Nijmegen], Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Gènes, Synapses et Cognition, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), UE 1354 Unité d'expérimentation sur les Ruminants de Theix, Institut National de la Recherche Agronomique (INRA)-Physiologie Animale et Systèmes d'Elevage (PHASE), Institut National de la Recherche Agronomique (INRA)-Unité d'expérimentation sur les Ruminants de Theix (UE RT), Radboud university [Nijmegen], McGill University, University of Bergen (UIB), Universität Heidelberg [Heidelberg], Beijing Normal University, University of California, University of Bonn, Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Department of Neurosciences [San Diego], Department of Cognitive Sciences [San Diego], The Hospital for Sick Children, University of Toronto, Toronto M5G 1X8, Canada, McGill University-McGill University, US 1367 MetaGénoPolis, Institut National de la Recherche Agronomique (INRA)-Département Microbiologie et Chaîne Alimentaire (MICA), Institut National de la Recherche Agronomique (INRA)-MetaGénoPolis (MGP), Yale University School of Medicine, King Faisal Specialist Hospital and Research Centre, Centre épigénétique et destin cellulaire (EDC (UMR_7216)), Texas Biomedical Research Institute [San Antonio, Texas], Bijvoet Center of Biomolecular Research, Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne 3101, Australia, Department of Genomics, Life & Brain Center, University of Bonn, Bonn D-53127, Germany, University of Oxford [Oxford]-FMRIB Centre- John Radcliffe Hospital [Oxford University Hospital], School of Psychology, University of Sussex, Brighton BN1 9QH, UK, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Department of Neurology [University of Calgary], Department of Clinical Neuroscience [University of Calgary], University of California [Irvine] (UCI), Medical Faculty [Mannheim]-Medical Faculty [Mannheim], Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Universidate de Vigo, Harvard University [Cambridge], Radboud university [Nijmegen]-Radboud university [Nijmegen], Université Libre de Bruxelles [Bruxelles] (ULB)-Hôpital Erasme (Bruxelles), Universität Leipzig [Leipzig]-Universität Leipzig [Leipzig], Centre de Recherche Magellan, Institut d'Administration des Entreprises (IAE) - Lyon-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon, Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Università degli Studi di Perugia (UNIPG), Department of neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland, Department of neurology, University of Eastern Finland-University Hospital of Kuopio-University of Eastern Finland-University Hospital of Kuopio, Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Service NEUROSPIN (NEUROSPIN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Bretagne Sud (UBS)-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), The Alzheimer’s Disease Neuroimaging Initiative, The CHARGE Consortium, EPIGEN, IMAGEN, SYS, Radboud University Medical Center [Nijmegen]-Radboud university [Nijmegen]-Radboud University Medical Center [Nijmegen]-Radboud university [Nijmegen], Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), FMRIB Centre- John Radcliffe Hospital [Oxford University Hospital]-University of Oxford [Oxford], Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut Pasteur [Paris], Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), University of Oxford [Oxford]- John Radcliffe Hospital [Oxford University Hospital]-FMRIB Centre, Neurology, Psychiatry, Anatomy and neurosciences, NCA - Neurobiology of mental health, EMGO - Mental health, NCA - Brain imaging technology, Biological Psychology, Cognitive Psychology, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, Neuroscience Campus Amsterdam - Brain Imaging Technology, EMGO+ - Mental Health, Child and Adolescent Psychiatry / Psychology, Epidemiology, Radiology & Nuclear Medicine, Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California, Los Angeles, California, USA, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre, MRC- SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, UK, Génétique humaine et Fonctions cognitives - Human Genetics and Cognitive Functions, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Greifswald 17487, Germany, Department of Psychiatry, University Medicine Greifswald, Greifswald 17489, Germany, Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands, Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK, Department of Computer Science, Lagos State University, Lagos, Nigeria, Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh EH4 2XU, UK, Heriot-Watt University [Edinburgh] ( HWU ), Institut National de la Recherche Agronomique ( INRA ) -Physiologie Animale et Systèmes d'Elevage ( PHASE ) -Unité d'expérimentation sur les Ruminants de Theix ( UE RT ), Department of Human Genetics, Radboud university medical center, Nijmegen 6500 HB, The Netherlands, Department of Cognitive Neuroscience, Radboud university medical center, Nijmegen 6500 HB, The Netherlands, NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo N-0316, Norway, NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo 0424, Norway, Montreal Neurological Institute [Montréal], NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway, Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen 5021, Norway, Physicochimie des Processus de Combustion et de l’Atmosphère - UMR 8522 ( PC2A ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands, International Max Planck Research School for Language Sciences, Nijmegen 6525 XD, The Netherlands, Human Genetics Branch and Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland 20892, USA, Department of Psychology, Yale University, New Haven, Connecticut 06511, USA, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02115, USA, University College of London [London] ( UCL ), Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA, Université de Bonn, Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 HL, The Netherlands, Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, UK, Imperial College London-School of public health-MRC-HPA Centre for Environment and Health, Cibersam (Centro Investigación Biomédica en Red Salud Mental), Madrid 28029, Spain, Institut Parisien de Chimie Moléculaire ( IPCM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Aging Research Center [Karolinska Institutet] ( ARC ), Max Planck Institute of Psychiatry, Munich 80804, Germany, Multimodal Imaging Laboratory, Department of Neurosciences, University of California, San Diego, California 92093, USA, Department of Cognitive Sciences, University of California, San Diego, California 92161, USA, Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia, Department of Psychology, University of Oslo, Oslo 0373, Norway, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Canada, Molecular and Cellular Therapeutics, The Royal College of Surgeons, Dublin 2, Ireland, Institut National de la Recherche Agronomique ( INRA ) -MetaGénoPolis ( MGP ) -Microbiologie et Chaîne Alimentaire ( MICA ), UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, London WC1N 3BG, UK, Department of Medicine, Imperial College London, London W12 0NN, UK, Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK, Yale School of Medicine, Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut 06106, USA, University College Dublin [Dublin] ( UCD ), Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK, Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia, Centre épigénétique et destin cellulaire ( EDC ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), School of public health-Tehran University of Medical Siences, University of New South Wales [Sydney] ( UNSW ), Texas Biomedical Research Institute, San Antonio, Texas 78245, USA, Institute of Neuroscience and Medicine ( INM-1 ), University of Basel ( Unibas ), Cambridge University, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA, University of Texas Health Science Center, San Antonio, Texas 78229, USA, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 20892, USA, Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald 17475, Germany, University Medical Center Groningen, University of Groningen, University of Greifswald, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA, NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, Maryland 21201, USA, nstitute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK, Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland 21201, USA, Department of Pathology and Cell Biology, Columbia University Medical Center, New York 10032, USA, Lymphocyte Cell Biology Unit, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA, University of Oslo ( UiO ) -Institute of Clinical Medicine-Oslo University Hospital, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo ( UiO ) -European Network of Bipolar Research Expert Centers (ENBREC) Group, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin 10117, Germany, Erasmus MC, Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health (NIH), Bethesda, Maryland, USA, Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, Central Institute of Mental Health, UMR 1098 Développement et Amélioration des Plantes, Institut National de la Recherche Agronomique ( INRA ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -MontpellierSupAgro ( MontpellierSupAgro ) -Génétique et amélioration des plantes ( G.A.P. ) -Développement et Amélioration des Plantes ( DAP ), Laboratory of Neuro Imaging [Los Angeles] ( LONI ), University of California at Los Angeles [Los Angeles] ( UCLA ), Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH4 2XU, UK, Genentech, South San Francisco, California 94080, USA, Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands, LUMC, Carver College of Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm SE-141 83, Sweden, Behavioral Epidemiology Section, National Institute on Aging Intramural Research Program, Baltimore, Maryland 20892, USA, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA, Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA, Centre Interlangues - Texte, Image, Langage ( TIL ), Université de Bourgogne ( UB ), Centre for Ultrahigh Bandwidth Devices for Optical Systems ( CUDOS ), Icahn School of Medicine at Mount Sinai [New York], The Mind Research Network & LBERI, Albuquerque, New Mexico 87106, USA, Department of ECE, University of New Mexico, Albuquerque, New Mexico 87131, USA, Scottish Association for Marine Science ( SAMS ), Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels 1070, Belgium, National Institutes of Health ( NIH ) -National Institute of Mental Health (NIMH), Harvard Medical School [Boston] ( HMS ) -Massachusetts General Hospital [Boston], Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242, USA, Luleå University of Technology ( LUT ), Broad Institute of MIT and Harvard, Massachusetts General Hospital, Vrije Universiteit Amsterdam [Amsterdam] ( VU ), Université Jean Moulin - Lyon III-Institut d'Administration des Entreprises (IAE) - Lyon, Institut de Socio-économie des Entreprises et des ORganisations ( ISEOR ), University Medicine Greifswald,-HELIOS Hospital Stralsund, Laboratoire d'Informatique de Grenoble ( LIG ), Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Osaka 565-0871, Japan, Karolinska University Hospital (Solna), Medical University of Łódź ( MUL ), National Institutes of Health ( NIH ), University of Perugia, Commonwealth Scientific and Industrial Research Organisation, University Medical Center Utrecht-Brain Center Rudolf Magnus, University of Nottingham, UK ( UON ), McConnell Brain Imaging Centre ( MNI ), The Hospital for sick children [Toronto] ( SickKids ), Department of Medical and Molecular Genetics, King’s College London, London SE1 9RT, UK, European Centre for Medium-Range Weather Forecasts ( ECMWF ), Lieber Institute for Brain Development, Baltimore, Maryland 21205, USA, Departments of Psychiatry, Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS ), Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Austrian Institute of Technology [Vienna] ( AIT ), Karlsruhe Institute of Technology ( KIT ), General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA, Department of Radiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA, Computer Science and Artificial Intelligence Laboratory [Cambridge] ( CSAIL ), Massachusetts Institute of Technology ( MIT ), Department of Epidemiology, University of Washington, Seattle, Washington, USA, Department of Neurology, University of Washington, Seattle, Washington, USA, Department of Physics, Stockholm University ( Department of Physics, Stockholm University ), Université de Lille, Sciences Humaines et Sociales, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA, Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA, Groupe d'Imagerie Neurofonctionnelle ( GIN - UMR 5296 ), Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ), Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA, Faculty of Medicine, University of Iceland, Reykjavik, Iceland, Department of Neurology, Boston University School of Medicine, Framingham Heart Study, Boston, MA, Department of Neurology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands, Laboratoire d'Ingénierie des Matériaux de Bretagne ( LIMATB ), Université de Bretagne Sud ( UBS ) -Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université de Brest ( UBO ) -Université de Brest ( UBO ), King's College, Department of Psychiatry, Radboud university medical center, Nijmegen 6500 HB, The Netherlands, and Broad Institute of © 2012 Nature America, Inc. All rights reserved. Nature Ge N etics aDV a NCE ONLINE PUBLIC a TION 7 l e t t e r s Harvard and MIT, Cambridge, Massachusetts, US
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CHROMATIN ,Male ,Netherlands Twin Register (NTR) ,Aging ,Identification ,nervous-system ,human geography ,SEGMENTATION ,Caudate nucleus ,Apoptosis ,Expression ,Genome-wide association study ,Striatum ,Hippocampal formation ,Hippocampus ,BASAL GANGLIA ,130 000 Cognitive Neurology & Memory ,Basal ganglia ,genetics [Gene Expression Regulation, Developmental] ,Hippocampal ,Child ,anatomy & histology [Skull] ,Aged, 80 and over ,Genetics ,Sex Characteristics ,KINECTIN ,Genome-wide association ,Multidisciplinary ,Putamen ,Brain ,Gene Expression Regulation, Developmental ,blood ,brain ,disease incidence ,genetic variation ,neurology ,Organ Size ,Human brain ,Middle Aged ,organization ,Magnetic Resonance Imaging ,genetics [Genetic Variation] ,Chromatin ,Dynamics ,genetics [Membrane Proteins] ,medicine.anatomical_structure ,genetics [Aging] ,Anatomy & histology ,[ SCCO.NEUR ] Cognitive science/Neuroscience ,Female ,ddc:500 ,anatomy & histology [Caudate Nucleus] ,Neuroinformatics ,EXPRESSION ,Adult ,Adolescent ,Evolution ,anatomy & histology [Hippocampus] ,ORGANIZATION ,genetics [Genetic Loci] ,Biology ,Article ,Young Adult ,SDG 3 - Good Health and Well-being ,Journal Article ,medicine ,Humans ,GENOME-WIDE ASSOCIATION ,General ,genetics [Apoptosis] ,Kinectin ,Aged ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,HIPPOCAMPAL ,IDENTIFICATION ,genetics [Organ Size] ,[SCCO.NEUR]Cognitive science/Neuroscience ,Skull ,segmentation ,Genetic Variation ,Membrane Proteins ,NERVOUS-SYSTEM ,anatomy & histology [Putamen] ,Genetic Loci ,KTN1 protein, human ,Caudate Nucleus ,anatomy & histology [Brain] ,Neuroscience ,Genome-Wide Association Study - Abstract
Contains fulltext : 144426.pdf (Publisher’s version ) (Closed access) Contains fulltext : 144426pre.pdf (Author’s version preprint ) (Open Access) The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 x 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction. 6 p.
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- 2015
376. Investigation of glutamine and GABA levels in patients with idiopathic generalized epilepsy using MEGAPRESS
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Chowdhury, Fahmida A, O'Gorman, Ruth L, Nashef, Lina, Elwes, Robert D, Edden, Richard A, Murdoch, James B, Barker, Gareth J, Richardson, Mark P, University of Zurich, and Chowdhury, Fahmida A
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10036 Medical Clinic ,Radiology Nuclear Medicine and imaging ,10076 Center for Integrative Human Physiology ,570 Life sciences ,biology ,2741 Radiology, Nuclear Medicine and Imaging ,610 Medicine & health - Published
- 2015
377. Diffusion in realistic biophysical systems can lead to aliasing effects in Diffusion Spectrum Imaging
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Lacerda, Luis Miguel, Sperl, Jonathan I., Menzel, Marion I., Sprenger, Tim, Barker, Gareth John, and Dell' Acqua, Flavio
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Purpose: Diffusion Spectrum imaging (DSI) is an imaging technique that has beensuccessfully applied to resolve white matter crossings in the human brain. However, itsaccuracy in complex microstructure environments has not been well characterized.Methods: Here we have simulated different tissue configurations, sampling schemes andprocessing steps to evaluate DSI performances’ under realistic biophysical conditions. A novelapproach to compute the orientation distribution function (ODF) has also been developed toinclude biophysical constraints, namely integration ranges compatible with axial fibrediffusivities.Results: Performed simulations identified several DSI configurations that consistently showaliasing artefacts caused by fast diffusion components for both isotropic diffusion and fibreconfigurations. The proposed method for ODF computation showed some improvement inreducing such artefacts and improving the ability to resolve crossings, while keeping thequantitative nature of the ODF.Conclusion: In this study we identified an important limitation of current DSI implementations,specifically the presence of aliasing due to fast diffusion components like those frompathological tissues, which are not well characterized, and can lead to artefactual fibrereconstructions. In order to minimise this issue, a new way of computing the ODF wasintroduced, which removes most of this artefacts and offers improved angular resolution.
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- 2015
378. The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India
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Zhang, Yuning, Vaidya, Nilakshi, Iyengar, Udita, Sharma, Eesha, Holla, Bharath, Ahuja, Chirag K., Barker, Gareth J., Basu, Debasish, Bharath, Rose Dawn, Chakrabarti, Amit, Desrivieres, Sylvane, Elliott, Paul, Fernandes, Gwen, Gourisankar, Amritha, Heron, Jon, Hickman, Matthew, Jacob, Preeti, Jain, Sanjeev, Jayarajan, Deepak, Kalyanram, Kartik, Kartik, Kamakshi, Krishna, Murali, Krishnaveni, Ghattu, Kumar, Keshav, Kumaran, Kalyanaraman, Kuriyan, Rebecca, Murthy, Pratima, Orfanos, Dimitri P., Purushottam, Meera, Rangaswamy, Madhavi, Kupard, Sunita Simon, Singh, Lenin, Singh, Roshan, Subodh, B. N., Thennarasu, Kandavel, Toledano, Mireille, Varghese, Mathew, Benegal, Vivek, and Schumann, Gunter
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The global burden of disease attributable to externalizing disorders such as alcohol misuse calls urgently for effective prevention and intervention. As our current knowledge is mainly derived from high-income countries such in Europe and North-America, it is difficult to address the wider socio-cultural, psychosocial context, and genetic factors in which risk and resilience are embedded in low- and medium-income countries. c-VEDA was established as the first and largest India-based multi-site cohort investigating the vulnerabilities for the development of externalizing disorders, addictions, and other mental health problems. Using a harmonised data collection plan coordinated with multiple cohorts in China, USA, and Europe, baseline data were collected from seven study sites between November 2016 and May 2019. Nine thousand and ten participants between the ages of 6 and 23 were assessed during this time, amongst which 1278 participants underwent more intensive assessments including MRI scans. Both waves of follow-ups have started according to the accelerated cohort structure with planned missingness design. Here, we present descriptive statistics on several key domains of assessments, and the full baseline dataset will be made accessible for researchers outside the consortium in September 2019. More details can be found on our website [cveda.org].
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- 2020
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379. Identifying biological markers for improved precision medicine in psychiatry
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Quinlan, Erin Burke, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Smolka, Michael N., Fröhner, Juliane H., Walter, Henrik, Whelan, Robert, and Schumann, Gunter
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Mental disorders represent an increasing personal and financial burden and yet treatment development has stagnated in recent decades. Current disease classifications do not reflect psychobiological mechanisms of psychopathology, nor the complex interplay of genetic and environmental factors, likely contributing to this stagnation. Ten years ago, the longitudinal IMAGEN study was designed to comprehensively incorporate neuroimaging, genetics, and environmental factors to investigate the neural basis of reinforcement-related behavior in normal adolescent development and psychopathology. In this article, we describe how insights into the psychobiological mechanisms of clinically relevant symptoms obtained by innovative integrative methodologies applied in IMAGEN have informed our current and future research aims. These aims include the identification of symptom groups that are based on shared psychobiological mechanisms and the development of markers that predict disease course and treatment response in clinical groups. These improvements in precision medicine will be achieved, in part, by employing novel methodological tools that refine the biological systems we target. We will also implement our approach in low- and medium-income countries to understand how distinct environmental, socioeconomic, and cultural conditions influence the development of psychopathology. Together, IMAGEN and related initiatives strive to reduce the burden of mental disorders by developing precision medicine approaches globally.
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- 2020
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380. Reward sensitivity predicts dopaminergic response in spatial neglect
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Li, Korina, Bentley, Paul, Nair, Ajoy, Halse, Omid, Barker, Gareth, Russell, Charlotte, Soto, David, and Malhotra, Paresh A.
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It has recently been revealed that spatial neglect can be modulated by motivational factors including anticipated monetary reward. A number of dopaminergic agents have been evaluated as treatments for neglect, but the results have been mixed, with no clear anatomical or cognitive predictors of dopaminergic responsiveness. Given that the effects of incentive motivation are mediated by dopaminergic pathways that are variably damaged in stroke, we tested the hypothesis that the modulatory influences of reward and dopaminergic drugs on neglect are themselves related.
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- 2020
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381. Dimensions of manic symptoms in youth:psychosocial impairment and cognitive performance in the IMAGEN sample
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Stringaris, Argyris, Castellanos-Ryan, Natalie, Banaschewski, Tobias, Barker, Gareth J, Bokde, Arun L, Bromberg, Uli, Büchel, Christian, Fauth-Bühler, Mira, Flor, Herta, Frouin, Vincent, Gallinat, Juergen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Itterman, Bernd, Lawrence, Claire, Nees, Frauke, Paillere-Martinot, Marie-Laure, Paus, Tomas, Pausova, Zdenka, Rietschel, Marcella, Smolka, Michael N, Schumann, Gunter, Goodman, Robert, and Conrod, Patricia
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Male ,Bipolar Disorder ,Adolescent ,Intelligence ,Original Articles ,behavioral disciplines and activities ,bipolar ,Mania ,Inhibition, Psychological ,mental disorders ,Humans ,Female ,adolescents ,creativity ,Psychomotor Performance - Abstract
BackgroundIt has been reported that mania may be associated with superior cognitive performance. In this study, we test the hypothesis that manic symptoms in youth separate along two correlated dimensions and that a symptom constellation of high energy and cheerfulness is associated with superior cognitive performance.MethodWe studied 1755 participants of the IMAGEN study, of average age 14.4 years (SD = 0.43), 50.7% girls. Manic symptoms were assessed using the Development and Wellbeing Assessment by interviewing parents and young people. Cognition was assessed using the Wechsler Intelligence Scale For Children (WISC-IV) and a response inhibition task.ResultsManic symptoms in youth formed two correlated dimensions: one termed exuberance, characterized by high energy and cheerfulness and one of undercontrol with distractibility, irritability and risk-taking behavior. Only the undercontrol, but not the exuberant dimension, was independently associated with measures of psychosocial impairment. In multivariate regression models, the exuberant, but not the undercontrolled, dimension was positively and significantly associated with verbal IQ by both parent- and self-report; conversely, the undercontrolled, but not the exuberant, dimension was associated with poor performance in a response inhibition task.ConclusionsOur findings suggest that manic symptoms in youth may form dimensions with distinct correlates. The results are in keeping with previous findings about superior performance associated with mania. Further research is required to study etiological differences between these symptom dimensions and their implications for clinical practice.
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- 2014
382. Muscarinic Receptor-Dependent Long Term Depression in the Perirhinal Cortex and Recognition Memory are Impaired in the rTg4510 Mouse Model of Tauopathy.
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Scullion, Sarah E., Barker, Gareth R. I., Warburton, E. Clea, Randall, Andrew D., and Brown, Jonathan T.
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MUSCARINIC acetylcholine receptors , *MUSCARINIC receptors , *MEMORY , *RECOGNITION (Psychology) - Abstract
Neurodegenerative diseases affecting cognitive dysfunction, such as Alzheimer's disease and fronto-temporal dementia, are often associated impairments in the visual recognition memory system. Recent evidence suggests that synaptic plasticity, in particular long term depression (LTD), in the perirhinal cortex (PRh) is a critical cellular mechanism underlying recognition memory. In this study, we have examined novel object recognition and PRh LTD in rTg4510 mice, which transgenically overexpress tauP301L. We found that 8-9 month old rTg4510 mice had significant deficits in long- but not short-term novel object recognition memory. Furthermore, we also established that PRh slices prepared from rTg4510 mice, unlike those prepared from wildtype littermates, could not support a muscarinic acetylcholine receptor-dependent form of LTD, induced by a 5 Hz stimulation protocol. In contrast, bath application of the muscarinic agonist carbachol induced a form of chemical LTD in both WT and rTg4510 slices. Finally, when rTg4510 slices were preincubated with the acetylcholinesterase inhibitor donepezil, the 5 Hz stimulation protocol was capable of inducing significant levels of LTD. These data suggest that dysfunctional cholinergic innervation of the PRh of rTg4510 mice, results in deficits in synaptic LTD which may contribute to aberrant recognition memory in this rodent model of tauopathy. [ABSTRACT FROM AUTHOR]
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- 2019
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383. Abnormal temporal lobe morphology in asymptomatic relatives of patients with hippocampal sclerosis: A replication study.
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Yaakub, Siti Nurbaya, Carr, Sarah J., Abela, Eugenio, Richardson, Mark P., Barker, Gareth J., Koutroumanidis, Michalis, and Elwes, Robert D. C.
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Summary: We investigated gray and white matter morphology in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE+HS) and first‐degree asymptomatic relatives of patients with mTLE+HS. Using T1‐weighted magnetic resonance imaging (MRI), we sought to replicate previously reported findings of structural surface abnormalities of the anterior temporal lobe in asymptomatic relatives of patients with mTLE+HS in an independent cohort. We performed whole‐brain MRI in 19 patients with mTLE+HS, 14 first‐degree asymptomatic relatives of mTLE+HS patients, and 32 healthy control participants. Structural alterations in patients and relatives compared to controls were assessed using automated hippocampal volumetry and cortical surface–based morphometry. We replicated previously reported cortical surface area contractions in the ipsilateral anterior temporal lobe in both patients and relatives compared to healthy controls, with asymptomatic relatives showing similar but less extensive changes than patients. These findings suggest morphologic abnormality in asymptomatic relatives of mTLE+HS patients, suggesting an inherited brain structure endophenotype. [ABSTRACT FROM AUTHOR]
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- 2019
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384. Mapping adolescent reward anticipation, receipt, and prediction error during the monetary incentive delay task.
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Cao, Zhipeng, Bennett, Marc, Orr, Catherine, Icke, Ilknur, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean‐Luc, Nees, Frauke, and Orfanos, Dimitri Papadopoulos
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The functional neuroanatomy and connectivity of reward processing in adults are well documented, with relatively less research on adolescents, a notable gap given this developmental period's association with altered reward sensitivity. Here, a large sample (n = 1,510) of adolescents performed the monetary incentive delay (MID) task during functional magnetic resonance imaging. Probabilistic maps identified brain regions that were reliably responsive to reward anticipation and receipt, and to prediction errors derived from a computational model. Psychophysiological interactions analyses were used to examine functional connections throughout reward processing. Bilateral ventral striatum, pallidum, insula, thalamus, hippocampus, cingulate cortex, midbrain, motor area, and occipital areas were reliably activated during reward anticipation. Bilateral ventromedial prefrontal cortex and bilateral thalamus exhibited positive and negative activation, respectively, during reward receipt. Bilateral ventral striatum was reliably active following prediction errors. Previously, individual differences in the personality trait of sensation seeking were shown to be related to individual differences in sensitivity to reward outcome. Here, we found that sensation seeking scores were negatively correlated with right inferior frontal gyrus activity following reward prediction errors estimated using a computational model. Psychophysiological interactions demonstrated widespread cortical and subcortical connectivity during reward processing, including connectivity between reward‐related regions with motor areas and the salience network. Males had more activation in left putamen, right precuneus, and middle temporal gyrus during reward anticipation. In summary, we found that, in adolescents, different reward processing stages during the MID task were robustly associated with distinctive patterns of activation and of connectivity. [ABSTRACT FROM AUTHOR]
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- 2019
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385. Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression.
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Vulser, Hélène, Paillère Martinot, Marie-Laure, Artiges, Eric, Miranda, Ruben, Penttilä, Jani, Grimmer, Yvonne, van Noort, Betteke M., Stringaris, Argyris, Struve, Maren, Fadai, Tahmine, Kappel, Viola, Goodman, Robert, Tzavara, Eleni, Massaad, Charbel, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Bromberg, Uli, Brühl, Rüdiger, and Büchel, Christian
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WHITE matter (Nerve tissue) ,MICROSTRUCTURE ,MENTAL depression ,ADOLESCENCE ,DIFFUSION tensor imaging ,EMOTIONS - Abstract
Objective: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome.Method: Adolescents with subthreshold depression (N=96) and healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging and whole brain tract-based spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followed up at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines spreading from the regions identified in the TBSS analysis and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. The authors searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold depression and depression at follow-up, and then explored the specificity of the findings.Results: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between subthreshold depression at baseline and depression at follow-up was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression.Conclusions: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents. [ABSTRACT FROM AUTHOR]- Published
- 2018
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386. The Role of Subgenual Resting-State Connectivity Networks in Predicting Prognosis in Major Depressive Disorder
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Fennema, Diede, Barker, Gareth J., O’Daly, Owen, Duan, Suqian, Carr, Ewan, Goldsmith, Kimberley, Young, Allan H., Moll, Jorge, and Zahn, Roland
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A seminal study found higher subgenual frontal cortex resting-state connectivity with 2 left ventral frontal regions and the dorsal midbrain to predict better response to psychotherapy versus medication in individuals with treatment-naïve major depressive disorder (MDD). Here, we examined whether these subgenual networks also play a role in the pathophysiology of clinical outcomes in MDD with early treatment resistance in primary care.
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- 2024
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387. The geological significance of electrical conductivity anomalies of the Ordovician-Silurian Moffat Shale Group, Northern Ireland
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Young, M.E., Cooper, Mark, Floyd, James, Barker, Gareth, Ture, Mohammednur, Hodgson, James, McConnell, Brian, Warke, Matthew, Young, M.E., Cooper, Mark, Floyd, James, Barker, Gareth, Ture, Mohammednur, Hodgson, James, McConnell, Brian, and Warke, Matthew
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The Tellus airborne geophysical survey revealed sets of narrow, linear, north-east to south-west, mostly parallel electrical conductivity (electromagnetic – EM) anomalies in the Longford–Down area. Subsequent geological mapping and ground geophysics have demonstrated that the anomalies coincide with and match the width of bedrock outcrop of the Moffat Shale Group. Ground-based geophysical surveys show variations in conductivity with highest values corresponding to carbon-rich mudstones. These findings allow the regional airborne geophysics to be interpreted with greater confidence for incorporation into bedrock geological maps, which underpin aspects of economic and environmental decision making.
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- 2016
388. A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
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Swiss National Science Foundation, European Research Council, Ministerio de Economía y Competitividad (España), Federal Ministry of Education and Research (Germany), Medical Research Council (UK), European Commission, German Research Foundation, Stacey, David, Lourdusamy, Anbarasu, Ruggeri, Barbara, Maroteaux, Matthieu, Jia, Tianye, Cattrell, Anna, Nymberg, Charlotte, Banaschewski, Tobias, Bhattacharyya, Sohinee, Band, Hamid, Barker, Gareth, Bokde, Arun, Buchel, Christian, Carvalho, Fabiana, Conrod, Patricia, Desrivieres, Sylvane, Easton, Alanna C., Fauth-Buehler, Mira, Fernández-Medarde, Alberto, Flor, Herta, Frouin, Vincent, Gallinat, Jurgen, Garavanh, Hugh, Heinz, Andreas, Ittermann, Bernd, Lathrop, Mark, Lawrence, Claire, Loth, Eva, Mann, Karl, Martinot, Jean-Luc, Nees, Frauke, Paus, Tomas, Pausova, Zdenka, Rietschel, Marcella, Rotter, Andrea, Santos de Dios, Eugenio, Smolka, Michael, Sommer, Wolfgang, Mameli, Manuel, Spanagel, Rainer, Girault, Jean-Antoine, Mueller, Christian, Schumann, Gunetrdd, Swiss National Science Foundation, European Research Council, Ministerio de Economía y Competitividad (España), Federal Ministry of Education and Research (Germany), Medical Research Council (UK), European Commission, German Research Foundation, Stacey, David, Lourdusamy, Anbarasu, Ruggeri, Barbara, Maroteaux, Matthieu, Jia, Tianye, Cattrell, Anna, Nymberg, Charlotte, Banaschewski, Tobias, Bhattacharyya, Sohinee, Band, Hamid, Barker, Gareth, Bokde, Arun, Buchel, Christian, Carvalho, Fabiana, Conrod, Patricia, Desrivieres, Sylvane, Easton, Alanna C., Fauth-Buehler, Mira, Fernández-Medarde, Alberto, Flor, Herta, Frouin, Vincent, Gallinat, Jurgen, Garavanh, Hugh, Heinz, Andreas, Ittermann, Bernd, Lathrop, Mark, Lawrence, Claire, Loth, Eva, Mann, Karl, Martinot, Jean-Luc, Nees, Frauke, Paus, Tomas, Pausova, Zdenka, Rietschel, Marcella, Rotter, Andrea, Santos de Dios, Eugenio, Smolka, Michael, Sommer, Wolfgang, Mameli, Manuel, Spanagel, Rainer, Girault, Jean-Antoine, Mueller, Christian, and Schumann, Gunetrdd
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[Background]: The mesolimbic dopamine system, composed primarily of dopaminergic neurons in the ventral tegmental area that project to striatal structures, is considered to be the key mediator of reinforcement-related mechanisms in the brain. Prompted by a genome-wide association meta-analysis implicating the Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2) gene in the regulation of alcohol intake in men, we have recently shown that male Rasgrf2–/– mice exhibit reduced ethanol intake and preference accompanied by a perturbed mesolimbic dopamine system. We therefore propose that these mice represent a valid model to further elucidate the precise genes and mechanisms regulating mesolimbic dopamine functioning. [Methods]: Transcriptomic data from the nucleus accumbens (NAcc) of male Rasgrf2–/– mice and wild-type controls were analyzed by weighted gene coexpression network analysis (WGCNA). We performed follow-up genetic association tests in humans using a sample of male adolescents from the IMAGEN study characterized for binge drinking (n = 905) and ventral striatal activation during an fMRI reward task (n = 608). [Results]: The WGCNA analyses using accumbal transcriptomic data revealed 37 distinct “modules,” or functionally related groups of genes. Two of these modules were significantly associated with Rasgrf2 knockout status: M5 (p < 0.001) and M6 (p < 0.001). In follow-up translational analyses we found that human orthologues for the M5 module were significantly (p < 0.01) enriched with genetic association signals for binge drinking in male adolescents. Furthermore, the most significant locus, originating from the EH-domain containing 4 (EHD4) gene (p < 0.001), was also significantly associated with altered ventral striatal activity in male adolescents performing an fMRI reward task (pempirical < 0.001). [Limitations]: It was not possible to determine the extent to which the M5 module was dysregulated in Rasgrf2–/– mice by perturbed mesolimbic dopamine
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- 2016
389. Correction: Global genetic variations predict brain response to faces
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Dickie, Erin W., Tahmasebi, Amir, French, Leon, Kovacevic, Natasa, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun, Büchel, Christian, Conrod, Patricia J., Flor, Herta, Garavan, Hugh, Gallinat, Jürgen, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Lawrence, Claire, Mann, Karl, Martinot, Jean-Luc, Nees, Frauke, Nichols, Thomas E., Lathrop, Mark, Loth, Eva, Pausova, Zdenka, Rietschel, Marcela, Smolka, Michal N., Ströhle, Andreas, Toro, Roberto, Schumann, Gunter, Paus, Tomáš, and HASH(0x5651ca074060)
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Cancer Research ,Facial expression ,medicine.diagnostic_test ,Restricted maximum likelihood ,business.industry ,BF ,Single-nucleotide polymorphism ,Variance (accounting) ,Biology ,QP ,Face (geometry) ,Genetic model ,Statistics ,Genetic variation ,Genetics ,medicine ,Artificial intelligence ,Functional magnetic resonance imaging ,business ,Molecular Biology ,Genetics (clinical) ,Ecology, Evolution, Behavior and Systematics - Abstract
Face expressions are a rich source of social signals. Here we estimated the proportion of phenotypic variance in the brain response to facial expressions explained by common genetic variance captured by ~500,000 single nucleotide polymorphisms. Using genomic-relationship-matrix restricted maximum likelihood (GREML), we related this global genetic variance to that in the brain response to facial expressions, as assessed with functional magnetic resonance imaging (fMRI) in a community-based sample of adolescents (n = 1,620). Brain response to facial expressions was measured in 25 regions constituting a face network, as defined previously. In 9 out of these 25 regions, common genetic variance explained a significant proportion of phenotypic variance (40–50%) in their response to ambiguous facial expressions; this was not the case for angry facial expressions. Across the network, the strength of the genotype-phenotype relationship varied as a function of the inter-individual variability in the number of functional connections possessed by a given region (R2 = 0.38, p
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- 2014
390. Early memory formation disrupted by atypical PKC inhibitor ZIP in the medial prefrontal cortex but not hippocampus
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Evuarherhe, Obaro, Barker, Gareth R. I., Savalli, Giorgia, Warburton, Elizabeth C., and Brown, Malcolm W.
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Male ,musculoskeletal, neural, and ocular physiology ,Association Learning ,Prefrontal Cortex ,Cell-Penetrating Peptides ,Neuropsychological Tests ,Hippocampus ,Article ,Endocytosis ,Rats ,Lipopeptides ,nervous system ,Memory ,Exploratory Behavior ,population characteristics ,Animals ,Receptors, AMPA ,human activities ,Protein Kinase Inhibitors ,health care economics and organizations ,Protein Kinase C - Abstract
Atypical isoforms of protein kinase C (aPKCs; particularly protein kinase M zeta: PKMζ) have been hypothesized to be necessary and sufficient for the maintenance of long-term potentiation (LTP) and long term memory by maintaining postsynaptic AMPA receptors via the GluA2 subunit. A myristoylated PKMζ pseudosubstrate peptide (ZIP) blocks PKMζ activity. We examined the actions of ZIP in medial prefrontal cortex (mPFC) and hippocampus in associative recognition memory in rats during early memory formation and memory maintenance. ZIP infusion in either hippocampus or mPFC impaired memory maintenance. However, early memory formation was impaired by ZIP in mPFC but not hippocampus; and blocking GluA2-dependent removal of AMPA receptors did not affect this impairment caused by ZIP in the mPFC. The findings indicate: (i) a difference in the actions of ZIP in hippocampus and medial prefrontal cortex, and (ii) a GluA2-independent target of ZIP (possibly PKCλ) in the mPFC during early memory formation.
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- 2014
391. Designing hyperbolic secant excitation pulses to reduce signal dropout in gradient-echo echo-planar imaging
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Wastling, Stephen J and Barker, Gareth J
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PurposeTo design hyperbolic secant (HS) excitation pulses to reduce signal dropout in the orbitofrontal and inferior temporal regions in gradient-echo echo-planar imaging (GE-EPI) for functional MRI (fMRI) applications.MethodsAn algorithm based on Bloch simulations optimizes the HS pulse parameters needed to give the desired signal response across the range of susceptibility gradients observed in the human head (approximately ±250 μT·m−1). The impact of the HS pulse on the signal, temporal signal-to-noise ratio, blood oxygen level–dependent (BOLD) sensitivity, and ability to detect resting state BOLD signal changes was assessed in six healthy male volunteers at 3T.ResultsThe optimized HS pulse (μ = 4.25, β = 3040 Hz, A0 = 12.3 μT, Δf = 4598 Hz) had a near uniform signal response for through-plane susceptibility gradients in the range ±250 μT·m−1. Signal, temporal signal-to-noise ratio, BOLD sensitivity, and the detectability of resting state networks were all partially recovered in the orbitofrontal and inferior temporal regions; however, there were signal losses of up to 50% in regions of homogeneous field (and signal loss from in-plane susceptibility gradients remained).ConclusionThe HS pulse reduced signal dropout and could be used to acquire task and resting state fMRI data without loss of spatial coverage or temporal resolution.
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- 2014
392. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
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Guadalupe, Tulio, primary, Mathias, Samuel R., additional, vanErp, Theo G. M., additional, Whelan, Christopher D., additional, Zwiers, Marcel P., additional, Abe, Yoshinari, additional, Abramovic, Lucija, additional, Agartz, Ingrid, additional, Andreassen, Ole A., additional, Arias-Vásquez, Alejandro, additional, Aribisala, Benjamin S., additional, Armstrong, Nicola J., additional, Arolt, Volker, additional, Artiges, Eric, additional, Ayesa-Arriola, Rosa, additional, Baboyan, Vatche G., additional, Banaschewski, Tobias, additional, Barker, Gareth, additional, Bastin, Mark E., additional, Baune, Bernhard T., additional, Blangero, John, additional, Bokde, Arun L.W., additional, Boedhoe, Premika S.W., additional, Bose, Anushree, additional, Brem, Silvia, additional, Brodaty, Henry, additional, Bromberg, Uli, additional, Brooks, Samantha, additional, Büchel, Christian, additional, Buitelaar, Jan, additional, Calhoun, Vince D., additional, Cannon, Dara M., additional, Cattrell, Anna, additional, Cheng, Yuqi, additional, Conrod, Patricia J., additional, Conzelmann, Annette, additional, Corvin, Aiden, additional, Crespo-Facorro, Benedicto, additional, Crivello, Fabrice, additional, Dannlowski, Udo, additional, de Zubicaray, Greig I., additional, de Zwarte, Sonja M.C., additional, Deary, Ian J., additional, Desrivières, Sylvane, additional, Doan, Nhat Trung, additional, Donohoe, Gary, additional, Dørum, Erlend S., additional, Ehrlich, Stefan, additional, Espeseth, Thomas, additional, Fernández, Guillén, additional, Flor, Herta, additional, Fouche, Jean-Paul, additional, Frouin, Vincent, additional, Fukunaga, Masaki, additional, Gallinat, Jürgen, additional, Garavan, Hugh, additional, Gill, Michael, additional, Suarez, Andrea Gonzalez, additional, Gowland, Penny, additional, Grabe, Hans J., additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Hagenaars, Saskia, additional, Hashimoto, Ryota, additional, Hauser, Tobias U., additional, Heinz, Andreas, additional, Hibar, Derrek P., additional, Hoekstra, Pieter J., additional, Hoogman, Martine, additional, Howells, Fleur M., additional, Hu, Hao, additional, Hulshoff Pol, Hilleke E., additional, Huyser, Chaim, additional, Ittermann, Bernd, additional, Jahanshad, Neda, additional, Jönsson, Erik G., additional, Jurk, Sarah, additional, Kahn, Rene S., additional, Kelly, Sinead, additional, Kraemer, Bernd, additional, Kugel, Harald, additional, Kwon, Jun Soo, additional, Lemaitre, Herve, additional, Lesch, Klaus-Peter, additional, Lochner, Christine, additional, Luciano, Michelle, additional, Marquand, Andre F., additional, Martin, Nicholas G., additional, Martínez-Zalacaín, Ignacio, additional, Martinot, Jean-Luc, additional, Mataix-Cols, David, additional, Mather, Karen, additional, McDonald, Colm, additional, McMahon, Katie L., additional, Medland, Sarah E., additional, Menchón, José M., additional, Morris, Derek W., additional, Mothersill, Omar, additional, Maniega, Susana Munoz, additional, Mwangi, Benson, additional, Nakamae, Takashi, additional, Nakao, Tomohiro, additional, Narayanaswaamy, Janardhanan C., additional, Nees, Frauke, additional, Nordvik, Jan E., additional, Onnink, A. Marten H., additional, Opel, Nils, additional, Ophoff, Roel, additional, Paillère Martinot, Marie-Laure, additional, Papadopoulos Orfanos, Dimitri, additional, Pauli, Paul, additional, Paus, Tomáš, additional, Poustka, Luise, additional, Reddy, Janardhan YC., additional, Renteria, Miguel E., additional, Roiz-Santiáñez, Roberto, additional, Roos, Annerine, additional, Royle, Natalie A., additional, Sachdev, Perminder, additional, Sánchez-Juan, Pascual, additional, Schmaal, Lianne, additional, Schumann, Gunter, additional, Shumskaya, Elena, additional, Smolka, Michael N., additional, Soares, Jair C., additional, Soriano-Mas, Carles, additional, Stein, Dan J., additional, Strike, Lachlan T., additional, Toro, Roberto, additional, Turner, Jessica A., additional, Tzourio-Mazoyer, Nathalie, additional, Uhlmann, Anne, additional, Hernández, Maria Valdés, additional, van den Heuvel, Odile A., additional, van der Meer, Dennis, additional, van Haren, Neeltje E.M ., additional, Veltman, Dick J., additional, Venkatasubramanian, Ganesan, additional, Vetter, Nora C., additional, Vuletic, Daniella, additional, Walitza, Susanne, additional, Walter, Henrik, additional, Walton, Esther, additional, Wang, Zhen, additional, Wardlaw, Joanna, additional, Wen, Wei, additional, Westlye, Lars T., additional, Whelan, Robert, additional, Wittfeld, Katharina, additional, Wolfers, Thomas, additional, Wright, Margaret J., additional, Xu, Jian, additional, Xu, Xiufeng, additional, Yun, Je-Yeon, additional, Zhao, JingJing, additional, Franke, Barbara, additional, Thompson, Paul M., additional, Glahn, David C., additional, Mazoyer, Bernard, additional, Fisher, Simon E., additional, and Francks, Clyde, additional
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- 2016
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393. Whole-Brain Atrophy Differences between Progressive Supranuclear Palsy and Idiopathic Parkinson’s Disease
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Guevara, Carlos, primary, Bulatova, Katherina, additional, Barker, Gareth J., additional, Gonzalez, Guido, additional, Crossley, Nicolas A., additional, and Kempton, Matthew J., additional
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- 2016
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394. Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity
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Heinrich, Angela, primary, Müller, Kathrin U., additional, Banaschewski, Tobias, additional, Barker, Gareth J., additional, Bokde, Arun L.W., additional, Bromberg, Uli, additional, Büchel, Christian, additional, Conrod, Patricia, additional, Fauth-Bühler, Mira, additional, Papadopoulos, Dimitri, additional, Gallinat, Jürgen, additional, Garavan, Hugh, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Mann, Karl, additional, Martinot, Jean-Luc, additional, Paus, Tomáš, additional, Pausova, Zdenka, additional, Smolka, Michael, additional, Ströhle, Andreas, additional, Rietschel, Marcella, additional, Flor, Herta, additional, Schumann, Gunter, additional, and Nees, Frauke, additional
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- 2016
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395. Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence
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Moura, Luciana Monteiro, primary, Kempton, Matthew, additional, Barker, Gareth, additional, Salum, Giovanni, additional, Gadelha, Ary, additional, Pan, Pedro Mario, additional, Hoexter, Marcelo, additional, Del Aquilla, Marco Antonio Gomes, additional, Picon, Felipe Almeida, additional, Anés, Mauricio, additional, Otaduy, Maria Concepcion Garcia, additional, Amaro, Edson, additional, Rohde, Luis Augusto, additional, McGuire, Philip, additional, Bressan, Rodrigo Affonseca, additional, Sato, João Ricardo, additional, and Jackowski, Andrea Parolin, additional
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- 2016
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396. A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
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Stacey, David, primary, Lourdusamy, Anbarasu, additional, Ruggeri, Barbara, additional, Maroteaux, Matthieu, additional, Jia, Tianye, additional, Cattrell, Anna, additional, Nymberg, Charlotte, additional, Banaschewski, Tobias, additional, Bhattacharyya, Sohinee, additional, Band, Hamid, additional, Barker, Gareth, additional, Bokde, Arun, additional, Buchel, Christian, additional, Carvalho, Fabiana, additional, Conrod, Patricia, additional, Desrivieres, Sylvane, additional, Easton, Alanna, additional, Fauth-Buehler, Mira, additional, Fernandez-Medarde, Alberto, additional, Flor, Herta, additional, Frouin, Vincent, additional, Gallinat, Jurgen, additional, Garavanh, Hugh, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Lathrop, Mark, additional, Lawrence, Claire, additional, Loth, Eva, additional, Mann, Karl, additional, Martinot, Jean-Luc, additional, Nees, Frauke, additional, Paus, Tomas, additional, Pausova, Zdenka, additional, Rietschel, Marcella, additional, Rotter, Andrea, additional, Santos, Eugenio, additional, Smolka, Michael, additional, Sommer, Wolfgang, additional, Mameli, Manuel, additional, Spanagel, Rainer, additional, Girault, Jean-Antoine, additional, Mueller, Christian, additional, and Schumann, Gunter, additional
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- 2016
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397. Mouse and Human Genetic Analyses Associate Kalirin with Ventral Striatal Activation during Impulsivity and with Alcohol Misuse
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Peña-Oliver, Yolanda, primary, Carvalho, Fabiana M., additional, Sanchez-Roige, Sandra, additional, Quinlan, Erin B., additional, Jia, Tianye, additional, Walker-Tilley, Tom, additional, Rulten, Stuart L., additional, Pearl, Frances M. G., additional, Banaschewski, Tobias, additional, Barker, Gareth J., additional, Bokde, Arun L. W., additional, Büchel, Christian, additional, Conrod, Patricia J., additional, Flor, Herta, additional, Gallinat, Jürgen, additional, Garavan, Hugh, additional, Heinz, Andreas, additional, Gowland, Penny, additional, Paillere Martinot, Marie-Laure, additional, Paus, Tomáš, additional, Rietschel, Marcella, additional, Robbins, Trevor W., additional, Smolka, Michael N., additional, Schumann, Gunter, additional, and Stephens, David N., additional
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- 2016
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398. MRI Measures of Cervical Cord Atrophy and Water Content in Neuromyelitis Optica (P4.149)
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Combes, Anna, primary, Matthews, Lucy, additional, Li, David, additional, McMullen, Katrina, additional, Barker, Gareth, additional, Williams, Steven, additional, Traboulsee, Anthony, additional, Palace, Jacqueline, additional, and Kolind, Shannon, additional
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- 2016
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399. Genome-wide discovered psychosis-risk gene ZNF804A impacts on white matter microstructure in health, schizophrenia and bipolar disorder
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Mallas, Emma-Jane, primary, Carletti, Francesco, additional, Chaddock, Christopher A., additional, Woolley, James, additional, Picchioni, Marco M., additional, Shergill, Sukhwinder S., additional, Kane, Fergus, additional, Allin, Matthew P.G., additional, Barker, Gareth J., additional, and Prata, Diana P., additional
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- 2016
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400. Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans
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Farmer, Adam D, Ban, Vin F, Coen, Steven J, Sanger, Gareth J, Barker, Gareth J, Gresty, Michael A, Giampietro, Vincent P, Williams, Steven C, Webb, Dominic-Luc, Hellström, Per M, Andrews, Paul L R, Aziz, Qasim, Farmer, Adam D, Ban, Vin F, Coen, Steven J, Sanger, Gareth J, Barker, Gareth J, Gresty, Michael A, Giampietro, Vincent P, Williams, Steven C, Webb, Dominic-Luc, Hellström, Per M, Andrews, Paul L R, and Aziz, Qasim
- Abstract
UNLABELLED: Nausea is a highly individual and variable experience. The reasons for this variability are incompletely understood although psychophysiological factors have been proposed. Herein we describe objective psychophysiological changes induced by the subjective sensation of motion sickness. In comparison to subjects who did not develop nausea, nausea-sensitive subjects demonstrated electrogastrographic and autonomic changes, which included an increase in sympathetic nervous system activity with a concomitant reduction in parasympathetic activity. Furthermore, differences were also evident in plasma ghrelin, and subcortical and cortical activity. These data have a number of important implications for future research examining the physiological mechanisms that underlie nausea: ○The physiological, hormonal and cortical patterns identified herein represent potential biomarkers of the physiological mechanisms of nausea. ○Reverse translation of the physiological factors identified may facilitate refinement of animal models used to investigate novel anti-emetic agents and emetic liability of candidate drugs, increasing their validity and translation of finding to humans. ABSTRACT: An integrated understanding of the physiological mechanisms involved in the genesis of nausea remains lacking. We aimed to describe the psychophysiological changes accompanying visually induced motion sickness, using a motion video, hypothesizing that differences would be evident between subjects who developed nausea in comparison to those who did not. A motion, or a control, stimulus was presented to 98 healthy subjects in a randomized crossover design. Validated questionnaires and a visual analogue scale (VAS) were used for the assessment of anxiety and nausea. Autonomic and electrogastrographic activity were measured at baseline and continuously thereafter. Plasma vasopressin and ghrelin were measured in response to the motion video. Subjects were stratified into quartiles based on VAS n
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- 2015
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