151. [Neuroprotective effects of a dipeptide mimetic on the GK-2 nerve growth factor in model of permanent common carotid artery occlusion in rats].
- Author
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Povarina PIu, Gudasheva TA, Vorontsova ON, Nikolaev SV, Antipova TA, Ostrovskaia RU, and Seredin SB
- Subjects
- Animals, Behavior, Animal drug effects, Brain Ischemia metabolism, Brain Ischemia pathology, Brain Ischemia physiopathology, Cell Survival drug effects, Cerebral Cortex metabolism, Cerebral Cortex pathology, Cerebrovascular Disorders drug therapy, Cerebrovascular Disorders metabolism, Cerebrovascular Disorders pathology, Cerebrovascular Disorders physiopathology, Chronic Disease, Disease Models, Animal, Gene Expression Regulation drug effects, HSP70 Heat-Shock Proteins biosynthesis, Male, Nerve Tissue Proteins biosynthesis, Rats, Biomimetic Materials pharmacology, Brain Ischemia drug therapy, Dipeptides pharmacology, Nerve Growth Factor pharmacology, Neuroprotective Agents pharmacology
- Abstract
The behavioral and biochemical effects of a new dipeptide mimetic of the GK-2 nerve growth factor (NGF) have been studied on a model of chronic cerebral ischemia induced by permanent common carotid artery occlusion in rats. It is established that subchronic intraperitoneal injections of GK-2 (0.5 mg/kg) 4 h after surgery, followed by seven more injections made every 24 h, fully prevent the death of operated animals and reduces the development of habitation deficit (open-field test) and decrease in exploratory activity (novel object examination) two weeks after surgery, as well as fully restores the viability of cerebral cortex cells and decreases the hyperexpression of HSP70 in cerebral cortex.
- Published
- 2012