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352. Abstract P366: Fasting Glucose and Insulin Resistance Trajectories in Young Adulthood and Cognitive Function in Middle Adulthood: the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Author

Bancks, Michael P, primary, Carnethon, Mercedes, additional, Jacobs, David R, additional, Launer, Lenore, additional, Reis, Jared, additional, Schreiner, Pamela J, additional, Shah, Ravi, additional, Sidney, Steve, additional, Yaffe, Kristine, additional, Yano, Yuichiro, additional, and Allen, Norrina B, additional

Published
2017
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356. Abstract 05: Association of 25-Year Body Mass Index Trajectories Throughout Early Adulthood With Nonalcoholic Fatty Liver Disease in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Author

VanWagner, Lisa B, primary, Khan, Sadiya, additional, NIng, Hongyan, additional, Siddique, Juned, additional, Lewis, Cora E, additional, Carr, John Jeffery, additional, Vos, Miriam, additional, Speliotes, Elizabeth, additional, Terrault, Norah, additional, Rinella, Mary, additional, Lloyd-Jones, Donald M, additional, and Allen, Norrina B, additional

Published
2017
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357. Abstract P081: Are Racial Differences in Cardiovascular Health Factors Explained by Cardiovascular Health Behaviors? The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Author

Carson, April P, primary, Goff, David C, additional, Jacobs, David R, additional, Kiefe, Catarina I, additional, Shikany, James M, additional, Sidney, Stephen, additional, Kershaw, Kiarri N, additional, Allen, Norrina B, additional, Lloyd-Jones, Donald M, additional, Laddu, Deepika, additional, Rana, Jamal S, additional, Ingram, Katherine H, additional, and Lewis, Cora E, additional

Published
2017
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359. Abstract P372: Trajectories in Fasting Glucose and Insulin Resistance During Young Adulthood and Measures of Cardiac Function and Structure in Middle Adulthood: the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Author

Bancks, Michael P, primary, Carnethon, Mercedes, additional, Chow, Lisa S, additional, Jacobs, David R, additional, Kishi, Satoru, additional, Lima, Joao, additional, Lloyd-Jones, Donald, additional, Reis, Jared, additional, Schreiner, Pam, additional, Zmora, Rachel, additional, and Allen, Norrina B, additional

Published
2017
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361. Abstract P076: Racial Differences in Maintaining Optimal Healthy Lifestyles Until 50 Years of Age: Prospective Data From the Coronary Artery Risk Development in Young Adults Study

Author

Booth, John N, primary, Allen, Norrina B, additional, Calhoun, David, additional, Carson, April P, additional, Deng, Luqin, additional, Goff, David C, additional, Redden, David T, additional, Reis, Jared P, additional, Shimbo, Daichi, additional, Shikany, James M, additional, Sidney, Stephen, additional, Spring, Bonnie J, additional, Lewis, Cora E, additional, and Muntner, Paul, additional

Published
2017
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362. Abstract P037: Epigenetic Markers of Cardiovascular Health Trajectories and Coronary Artery Calcification in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Author

Hou, Lifang, primary, Zheng, Yinan, additional, Allen, Norrina B., additional, Nannini, Drew, additional, Zhang, Zhou, additional, Liu, Lei, additional, Zhang, Wei, additional, Krefman, Amy E., additional, Fornage, Myriam, additional, Ning, Hongyan, additional, Lewis, Cora E., additional, Schreiner, Pamela, additional, Sidney, Stephen, additional, Shikany, James, additional, Liu, Kiang, additional, Lloyd-Jones, Donald M., additional, and Greenland, Philip, additional

Published
2017
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366. Cardiovascular Health and Incident Cardiovascular Disease and Cancer: The Women's Health Initiative

Author

Foraker, Randi E., Abdel-Rasoul, Mahmoud, Kuller, Lewis H., Jackson, Rebecca D., Van Horn, Linda, Seguin, Rebecca A., Safford, Monika M., Wallace, Robert B., Kucharska-Newton, Anna M., Robinson, Jennifer G., Martin, Lisa W., Agha, Golareh, Hou, Lifang, Allen, Norrina B., and Tindle, Hilary A.

Subjects
Aged, 80 and over, Blood Glucose, Health Status, Health Behavior, Smoking, Blood Pressure, Middle Aged, Article, United States, Body Mass Index, Diet, Cholesterol, Socioeconomic Factors, Cardiovascular Diseases, Risk Factors, Neoplasms, Humans, Women's Health, Female, Exercise, Aged, Proportional Hazards Models
Abstract

The American Heart Association's "Simple 7" offers a practical public health conceptualization of cardiovascular health (CVH). CVH predicts incident cardiovascular disease (CVD) in younger populations, but has not been studied in a large, diverse population of aging postmenopausal women. The extent to which CVH predicts cancer in postmenopausal women is unknown.Multivariable Cox regression estimated hazard ratios and 95% CIs for the association between CVH and incident CVD, any cancer, and cancer subtypes (lung, colorectal, and breast) among 161,809 Women's Health Initiative observational study and clinical trial participants followed from 1993 through 2010. Data were analyzed in 2013. CVH score was characterized as the number (0 [worst] to 7 [best]) of the American Heart Association's ideal CVH behaviors and factors at baseline: smoking, BMI, physical activity, diet, total cholesterol, blood pressure, and fasting glucose.Median follow-up was approximately 13 years. Fewer minorities and less educated women achieved ideal CVH, a common benchmark. In adjusted models, compared with women with the highest (best) CVH scores, those with the lowest (worst) CVH scores had nearly seven times the hazard of incident CVD (6.83, 95% CI=5.83, 8.00) and 52% greater risk of incident cancer (1.52, 95% CI=1.35, 1.72). Ideal CVH was most strongly inversely associated with lung cancer, then colorectal cancer, and then breast cancer.Lower ideal CVH is more common among minority and less educated postmenopausal women and predicts increased risk of CVD and cancer in this population, emphasizing the importance of prevention efforts among vulnerable older adults.

Published
2015

367. Fatherhood and Cardiovascular Health, Disease, and Mortality: Associations From the Multi-Ethnic Study of Atherosclerosis

Author

Parker, John James, Garfield, Craig F., Simon, Clarissa D., Colangelo, Laura A., Bancks, Michael P., and Allen, Norrina B.

Abstract

•Cardiovascular health in older age was worse for fathers than for nonfathers.•Cardiovascular health was worse for men who became fathers at a young age (i.e., <25 years).•Fatherhood's association with cardiovascular health and mortality differed by race.•Black fathers had lower age-adjusted mortality rates than Black nonfathers.•Incident cardiovascular disease did not differ between fathers and nonfathers.

Published
2024
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368. Long-term cumulative blood pressure in young adults and incident heart failure, coronary heart disease, stroke, and cardiovascular disease: The CARDIA study

Author

Nwabuo, Chike C, Appiah, Duke, Moreira, Henrique T, Vasconcellos, Henrique D, Yano, Yuichiro, Reis, Jared P, Shah, Ravi V, Murthy, Venkatesh L, Allen, Norrina B, Sidney, Stephen, Muntner, Paul, Lewis, Cora E, Lloyd-Jones, Donald M, Schreiner, Pamela J, Gidding, Samuel S, and Lima, João AC

Abstract

Aims Cumulative blood pressure (BP) is a measure that incorporates the severity and duration of BP exposure. The prognostic significance of cumulative BP in young adults for cardiovascular diseases (CVDs) in comparison to BP severity alone is, however, unclear.Methods and results We investigated 3667 Coronary Artery Risk Development in Young Adults participants who attended six visits over 15 years (year-0 (1985–1986), year-2, year-5, year-7, year-l0, and year-15 exams). Cumulative BP was calculated as the area under the curve (mmHg × years) from year 0 through year 15. Cox models assessed the association between cumulative BP (year 0 through year 15), current BP (year 15), and BP change (year 0 and year 15) and CVD outcomes. Mean (standard deviation) age at year 15 was 40.2 (3.6) years, 44.1% were men, and 44.1% were African-American. Over a median follow-up of 16 years, there were 47 heart failure (HF), 103 coronary heart disease (CHD), 71 stroke, and 191 CVD events. Cumulative systolic BP (SBP) was associated with HF (hazard ratio (HR) = 2.14 (1.58–2.90)), CHD (HR = 1.49 (1.19–1.87)), stroke (HR = 1.81 (1.38–2.37)), and CVD (HR = 1.73 (1.47–2.05)). For CVD, the C-statistic for SBP (year 15) was 0.69 (0.65–0.73) and change in C-statistic with the inclusion of SBP change and cumulative SBP was 0.60 (0.56–0.65) and 0.72 (0.69–0.76), respectively. For CVD, using year-15 SBP as a reference, the net reclassification index (NRI) for cumulative SBP was 0.40 (p< 0.0001) and the NRI for SBP change was 0.22 (p= 0.001).Conclusions Cumulative BP in young adults was associated with the subsequent risk of HF, CHD, stroke, and CVD. Cumulative BP provided incremental prognostic value and improved risk reclassification for CVD, when compared to single BP assessments or changes in BP.

Published
2024
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370. Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies

Author

Chauhan, Ganesh, primary, Arnold, Corey R, additional, Chu, Audrey Y, additional, Fornage, Myriam, additional, Reyahi, Azadeh, additional, Bis, Joshua C, additional, Havulinna, Aki S, additional, Sargurupremraj, Muralidharan, additional, Smith, Albert Vernon, additional, Adams, Hieab H H, additional, Choi, Seung Hoan, additional, Pulit, Sara L, additional, Trompet, Stella, additional, Garcia, Melissa E, additional, Manichaikul, Ani, additional, Teumer, Alexander, additional, Gustafsson, Stefan, additional, Bartz, Traci M, additional, Bellenguez, Céline, additional, Vidal, Jean Sebastien, additional, Jian, Xueqiu, additional, Kjartansson, Olafur, additional, Wiggins, Kerri L, additional, Satizabal, Claudia L, additional, Xue, Flora, additional, Ripatti, Samuli, additional, Liu, Yongmei, additional, Deelen, Joris, additional, den Hoed, Marcel, additional, Bevan, Steve, additional, Hopewell, Jemma C, additional, Malik, Rainer, additional, Heckbert, Susan R, additional, Rice, Kenneth, additional, Smith, Nicholas L, additional, Levi, Christopher, additional, Sharma, Pankaj, additional, Sudlow, Cathie LM, additional, Nik, Ali Moussavi, additional, Cole, John W, additional, Schmidt, Reinhold, additional, Meschia, James, additional, Thijs, Vincent, additional, Lindgren, Arne, additional, Melander, Olle, additional, Grewal, Raji P, additional, Sacco, Ralph L, additional, Rundek, Tatjana, additional, Rothwell, Peter M, additional, Arnett, Donna K, additional, Jern, Christina, additional, Johnson, Julie A, additional, Benavente, Oscar R, additional, Wassertheil-Smoller, Sylvia, additional, Lee, Jin-Moo, additional, Wong, Quenna, additional, Aparicio, Hugo J, additional, Engelter, Stefan T, additional, Kloss, Manja, additional, Leys, Didier, additional, Pezzini, Alessandro, additional, Buring, Julie E, additional, Ridker, Paul M, additional, Berr, Claudine, additional, Dartigues, Jean-François, additional, Hamsten, Anders, additional, Magnusson, Patrik K, additional, Traylor, Matthew, additional, Pedersen, Nancy L, additional, Lannfelt, Lars, additional, Lindgren, Lars, additional, Lindgren, Cecilia M, additional, Morris, Andrew P, additional, Jimenez-Conde, Jordi, additional, Montaner, Joan, additional, Radmanesh, Farid, additional, Slowik, Agnieszka, additional, Woo, Daniel, additional, Hofman, Albert, additional, Koudstaal, Peter J, additional, Portegies, Marileen L P, additional, Uitterlinden, André G, additional, de Craen, Anton J M, additional, Ford, Ian, additional, Jukema, J Wouter, additional, Stott, David J, additional, Allen, Norrina B, additional, Sale, Michele M, additional, Johnson, Andrew D, additional, Bennett, David A, additional, De Jager, Philip L, additional, White, Charles C, additional, Grabe, Hans Jörgen, additional, Markus, Marcello Ricardo Paulista, additional, Schminke, Ulf, additional, Boncoraglio, Giorgio B, additional, Clarke, Robert, additional, Kamatani, Yoichiro, additional, Dallongeville, Jean, additional, Lopez, Oscar L, additional, Rotter, Jerome I, additional, Nalls, Michael A, additional, Gottesman, Rebecca F, additional, Griswold, Michael E, additional, Knopman, David S, additional, Windham, B Gwen, additional, Beiser, Alexa, additional, Markus, Hugh S, additional, Vartiainen, Erkki, additional, French, Curtis R, additional, Dichgans, Martin, additional, Pastinen, Tomi, additional, Lathrop, Mark, additional, Gudnason, Vilmundur, additional, Kurth, Tobias, additional, Psaty, Bruce M, additional, Harris, Tamara B, additional, Rich, Stephen S, additional, deStefano, Anita L, additional, Schmidt, Carsten Oliver, additional, Worrall, Bradford B, additional, Rosand, Jonathan, additional, Salomaa, Veikko, additional, Mosley, Thomas H, additional, Ingelsson, Erik, additional, van Duijn, Cornelia M, additional, Tzourio, Christophe, additional, Rexrode, Kathryn M, additional, Lehmann, Ordan J, additional, Launer, Lenore J, additional, Ikram, M Arfan, additional, Carlsson, Peter, additional, Chasman, Daniel I, additional, Childs, Sarah J, additional, Longstreth, William T, additional, Seshadri, Sudha, additional, and Debette, Stéphanie, additional

Published
2016
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371. Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies

Author

Allen, Norrina B., primary, Lloyd-Jones, Donald, additional, Hwang, Shih-Jen, additional, Rasmussen-Torvik, Laura, additional, Fornage, Myriam, additional, Morrison, Alanna C., additional, Baldridge, Abigail S., additional, Boerwinkle, Eric, additional, Levy, Daniel, additional, Cupples, L. Adrienne, additional, Fox, Caroline S., additional, Thanassoulis, George, additional, Dufresne, Line, additional, Daviglus, Martha, additional, Johnson, Andrew D., additional, Reis, Jared, additional, Rotter, Jerome, additional, Palmas, Walter, additional, Allison, Mathew, additional, Pankow, James S., additional, and O'Donnell, Christopher J., additional

Published
2016
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372. Abstract MP05: Life’s Simple 7 and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis

Author

Ogunmoroti, Oluseye, primary, Oni, Ebenezer, additional, Allen, Norrina B, additional, Spatz, Erica S, additional, Rana, Jamal S, additional, Virani, Salim S, additional, Blankstein, Ron, additional, Blumenthal, Roger S, additional, Veledar, Emir, additional, Szklo, Moyses, additional, Blaha, Michael J, additional, and Nasir, Khurram, additional

Published
2016
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373. Abstract 02: American Heart Association (AHA)’s Life’s Simple 7 and Risk of Lower Extremity Peripheral Artery Disease (PAD): The Multi-Ethnic Study of Atherosclerosis (MESA)

Author

Wassel, Christina L, primary, Rasmussen-Torvik, Laura, additional, Frazier-Wood, Alexis, additional, Allison, Matthew A, additional, McDermott, Mary M, additional, Folsom, Aaron R, additional, Lloyd-Jones, Donald M, additional, Allen, Norrina B, additional, Burke, Gregory L, additional, Szklo, Moyses, additional, Criqui, Michael H, additional, and Cushman, Mary, additional

Published
2016
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375. Cardiovascular Health and Incident Cardiovascular Disease and Cancer

Author

Foraker, Randi E., primary, Abdel-Rasoul, Mahmoud, additional, Kuller, Lewis H., additional, Jackson, Rebecca D., additional, Van Horn, Linda, additional, Seguin, Rebecca A., additional, Safford, Monika M., additional, Wallace, Robert B., additional, Kucharska-Newton, Anna M., additional, Robinson, Jennifer G., additional, Martin, Lisa W., additional, Agha, Golareh, additional, Hou, Lifang, additional, Allen, Norrina B., additional, and Tindle, Hilary A., additional

Published
2016
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376. Body mass index trajectories in young adulthood predict non‐alcoholic fatty liver disease in middle age: The CARDIA cohort study.

Author

Rinella, Mary E., VanWagner, Lisa B., Ning, Hongyan, Siddique, Juned, Allen, Norrina B., Khan, Sadiya S., Lloyd‐Jones, Donald M., Lewis, Cora E., Carr, John J., Vos, Miriam B., Speliotes, Elizabeth, and Terrault, Norah A.

Subjects
BODY mass index, OVERWEIGHT persons, FATTY liver, OBESITY complications, OBESITY risk factors, PATIENTS, DISEASE risk factors
Abstract

Abstract: Background & Aims: Non‐alcoholic fatty liver disease is an epidemic. Identifying modifiable risk factors for non‐alcoholic fatty liver disease development is essential to design effective prevention programmes. We tested whether 25‐year patterns of body mass index change are associated with midlife non‐alcoholic fatty liver disease. Methods: In all, 4423 participants from Coronary Artery Risk Development in Young Adults, a prospective population‐based biracial cohort (age 18‐30), underwent body mass index measurement at baseline (1985‐1986) and 3 or more times over 25 years. At Year 25, 3115 had liver fat assessed by non‐contrast computed tomography. Non‐alcoholic fatty liver disease was defined as liver attenuation ≤40 Hounsfield Units after exclusions. Latent mixture modelling identified 25‐year trajectories in body mass index per cent change (%Δ) from baseline. Results: We identified four distinct trajectories of BMI%Δ: stable (26.2% of cohort, 25‐year BMI %Δ = 3.1%), moderate increase (46.0%, BMI%Δ = 21.7%), high increase (20.9%, BMI%Δ = 41.9%) and extreme increase (6.9%, BMI%Δ = 65.9%). Y25 non‐alcoholic fatty liver disease prevalence was higher in groups with greater BMI %Δ: 4.1%, 9.3%, 13.0%, and 17.6%, respectively (P‐trend <.0001). In multivariable analyses, participants with increasing BMI%Δ had increasingly greater odds of non‐alcoholic fatty liver disease compared to the stable group: OR: 3.35 (95% CI: 2.07‐5.42), 7.80 (4.60‐13.23) and 12.68 (6.68‐24.09) for moderate, high and extreme body mass index increase, respectively. Associations were only moderately attenuated when adjusted for baseline or Y25 body mass index. Conclusions: Trajectories of weight gain during young adulthood are associated with greater non‐alcoholic fatty liver disease prevalence in midlife independent of metabolic covariates and baseline or concurrent body mass index highlighting the importance of weight maintenance throughout adulthood as a target for primary non‐alcoholic fatty liver disease prevention. [ABSTRACT FROM AUTHOR]

Published
2018
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377. Visit-to-Visit Blood Pressure Variability in Young Adulthood and Hippocampal Volume and Integrity at Middle Age: The CARDIA Study (Coronary Artery Risk Development in Young Adults).

Author

Yuichiro Yano, Reis, Jared P., Levine, Deborah A., Bryan, R. Nick, Viera, Anthony J., Daichi Shimbo, Tedla, Yacob G., Allen, Norrina B., Schreiner, Pamela J., Bancks, Michael P., Sidney, Stephen, Pletcher, Mark J., Kiang Liu, Greenland, Philip, Lloyd-Jones, Donald M., Launer, Lenore J., Yano, Yuichiro, Shimbo, Daichi, and Liu, Kiang

Abstract

The aims of this study are to assess the relationships of visit-to-visit blood pressure (BP) variability in young adulthood to hippocampal volume and integrity at middle age. We used data over 8 examinations spanning 25 years collected in the CARDIA study (Coronary Artery Risk Development in Young Adults) of black and white adults (age, 18-30 years) started in 1985 to 1986. Visit-to-visit BP variability was defined as by SDBP and average real variability (ARVBP, defined as the absolute differences of BP between successive BP measurements). Hippocampal tissue volume standardized by intracranial volume (%) and integrity assessed by fractional anisotropy were measured by 3-Tesla magnetic resonance imaging at the year-25 examination (n=545; mean age, 51 years; 54% women and 34% African Americans). Mean systolic BP (SBP)/diastolic BP levels were 110/69 mm Hg at year 0 (baseline), 117/73 mm Hg at year 25, and ARVSBP and SDSBP were 7.7 and 7.9 mm Hg, respectively. In multivariable-adjusted linear models, higher ARVSBP was associated with lower hippocampal volume (unstandardized regression coefficient [standard error] with 1-SD higher ARVSBP: -0.006 [0.003]), and higher SDSBP with lower hippocampal fractional anisotropy (-0.02 [0.01]; all P<0.05), independent of cumulative exposure to SBP during follow-up. Conversely, cumulative exposure to SBP and diastolic BP was not associated with hippocampal volume. There was no interaction by sex or race between ARVSBP or SDSBP with hippocampal volume or integrity. In conclusion, visit-to-visit BP variability during young adulthood may be useful in assessing the potential risk for reductions in hippocampal volume and integrity in midlife. [ABSTRACT FROM AUTHOR]

Published
2017
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378. Abstract 11907: The Association of Life’s Simple 7 Health Metrics and Incident Non-Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis

Author

Ogunmoroti, Oluseye, primary, Allen, Norrina B, additional, Michos, Erin D, additional, Rundek, Tatjana, additional, Rana, Jamal, additional, Blankstein, Ron, additional, Blumenthal, Roger S, additional, Cushman, Mary, additional, Blaha, Michael J, additional, Veledar, Emir, additional, and Nasir, Khurram, additional

Published
2015
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387. Abstract MP04: 25 year Physical Activity Trajectories and Development of Subclinical Coronary Artery Disease as Measured by Coronary Artery Calcium: the CARDIA Study

Author

Rana, Jamal S, primary, Murillo, Rosenda, additional, Quesenberry, Charles P, additional, Sorel, Michael E, additional, Sternfeld, Barbara, additional, Gabriel, Kelley P, additional, Carnethon, Mercedes R, additional, Liu, Kiang, additional, Reis, Jared P, additional, Allen, Norrina B, additional, Lloyd-Jones, Donald, additional, Carr, J. Jeffrey, additional, and Sidney, Stephen, additional

Published
2015
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389. Association of neighborhood characteristics with cardiovascular health in the multi-ethnic study of atherosclerosis.

Author

Unger, Erin, Unger, Erin, Diez-Roux, Ana V, Lloyd-Jones, Donald M, Mujahid, Mahasin S, Nettleton, Jennifer A, Bertoni, Alain, Badon, Sylvia E, Ning, Hongyan, Allen, Norrina B, Unger, Erin, Unger, Erin, Diez-Roux, Ana V, Lloyd-Jones, Donald M, Mujahid, Mahasin S, Nettleton, Jennifer A, Bertoni, Alain, Badon, Sylvia E, Ning, Hongyan, and Allen, Norrina B

Abstract

BackgroundThe concept of cardiovascular health (CVH) was introduced as a global measure of one's burden of cardiovsacular risk factors. Previous studies established the relationship between neighborhood characteristics and individual cardiovascular risk factors. However, the relationship between neighborhood environment and overall CVH remains unknown.Methods and resultsWe analyzed data from the Multi-Ethnic Study of Atherosclerosis baseline examination (2000–2002). Mean age was 61.6 years, and 52% were women. Ideal, intermediate, and poor categories of cholesterol, body mass index, diet, physical activity, fasting glucose, blood pressure, and smoking were defined according to the American Heart Association 2020 Strategic Goals, assigned an individual score, and summed to create an overall score. CVH scores were categorized into ideal (11–14 points), intermediate (9–10), and poor (0–8). Neighborhood exposures included favorable food store and physical activity resources densities (by 1-mile buffer), reported healthy food availability,walking/physical activity environment, safety, and social cohesion (by census tract). Multinomial logistic regression was used to determine the association of each characteristic with ideal and intermediate CVH, adjusted for demographics and neighborhood socioeconomic status. Over 20% of Multi-Ethnic Study of Atherosclerosis participants had an ideal CVH score at baseline. In fully adjusted models, favorable food stores (odds ratio=1.22; 1.06–1.40), physical activity resources(odds ratio=1.19; 1.08–1.31), walking/physical activity environment (odds ratio=1.20; 1.05–1.37), and neighborhood socioeconomic status (odds ratio=1.22; 1.11–1.33) were associated with higher odds of having an ideal CVH score.ConclusionsNeighborhood environment including favorable food stores, physical activity resources, walking/physical activity environment, and neighborhood socioeconomic status are associated with ideal CVH. Further research is needed to invest

Published
2014

390. Depressive Symptom Subgroups and Their Association with Prevalent and Incident Cardiovascular Risk Factors in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Author

Chirinos, Diana A., Kershaw, Kiarri N., Allen, Norrina B., Carroll, Allison J., Lewis, Tené T., Schreiner, Pamela J., Lewis, Cora E., Kiefe, Catarina I., Mezuk, Briana, and Carnethon, Mercedes R.

Subjects
*CARDIOVASCULAR diseases risk factors, *STRUCTURAL equation modeling, *OBESITY, *HYPERTENSION, *MULTIPLE regression analysis, *DIABETES, *CARDIOVASCULAR diseases, *RISK assessment, *MENTAL depression, *CORONARY artery disease, *RESEARCH funding, *DESCRIPTIVE statistics, *CENTER for Epidemiologic Studies Depression Scale, *PROPORTIONAL hazards models, *DISEASE risk factors, *ADULTS
Abstract

Background: We sought to identify depressive symptom subgroups in a community sample of young adults, investigate their stability over time, and determine their association with prevalent and incident cardiovascular disease (CVD) risk factors. Method: Participants were 3377 adults from the Coronary Artery Risk Development in Young Adults study. Using latent class and latent transition analysis, we derived subgroups based on items of the 20-item version of the Center for Epidemiologic Studies Depression Scale in 1990, and examined patterns of change over a 10-year period (1990–2000). Cox regression models were used to examine associations between subgroup membership and prevalent (2000) and incident (2000 to 2016) obesity, hypertension, and diabetes. Results: Three baseline subgroups were identified and labeled: "No Symptoms" (63.5%), "Lack of Positive Affect" (PA, 25.6%), and "Depressed Mood" (10.9%). At 10-year follow-up, individuals in "No Symptoms" subgroup had the highest probability (0.84) of being classified within the same subgroup. Participants classified as "Lack of PA" were likely (0.46) to remain in the same subgroup or be classified as "No Symptoms." Participants in the "Depressed Mood" were most likely to transition to the "Lack of PA" subgroup (0.38). Overall, 30.5% of participants transitioned between subgroups, with 11.4% classified as "Worsening" and 19.1% as "Improving." Relative to the "No Symptoms Stable," other subgroups ("Depressed Stable," "Worsening," and "Improving") were associated with prevalent obesity and hypertension. Conclusion: We identified distinct depressive symptom subgroups that are variably stable over time, and their change patterns were differentially associated with CVD risk factor prevalence. [ABSTRACT FROM AUTHOR]

Published
2023
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394. Abstract 05: Longer Duration of Obesity Beginning in Young Adulthood is Associated with Greater Left Ventricular Mass and Worse Left Ventricular Function in Middle-Age: The CARDIA Study

Author

Reis, Jared P, primary, Allen, Norrina B, additional, Barone-Gibbs, Bethany, additional, Lee, Joyce M, additional, Lewis, Cora E, additional, Lima, Joao, additional, Lloyd-Jones, Donald, additional, Loria, Catherine M, additional, Powell-Wiley, Tiffany M, additional, Wei, Gina, additional, and Liu, Kiang, additional

Published
2014
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399. Abstract 047: Trajectories of Maintaining Recommended Amounts of Physical Activity in Young Adulthood and Associations with Abdominal Adiposity in Middle Age: The Cardia Study

Author

Shay, Christina M, primary, Colangelo, Laura, additional, Carnethon, Mercedes R, additional, Liu, Kiang, additional, Allen, Norrina B, additional, Lewis, Cora E, additional, Reis, Jared P, additional, Jacobs, David R, additional, Terry, J G, additional, and Carr, J J, additional

Published
2013
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400. Abstract P126: Relation of Depressive Symptoms to the Cross-Sectional and Longitudinal Association of Low Cardiovascular Risk with Subclinical Atherosclerosis - The Chicago Healthy Aging Study (CHAS)

Author

Hernandez, Rosalba, primary, Allen, Norrina B, additional, Liu, Kiang, additional, Stamler, Jeremiah, additional, Reid, Kathryn J, additional, Zee, Phyllis C, additional, Wu, Donghong, additional, Kang, Joseph, additional, Garside, Daniel B, additional, and Daviglus, Martha, additional

Published
2013
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