180 results on '"Alhasan, Khalid"'
Search Results
152. Heparin-free Sustained Low-Efficiency Dialysis in Critical Children in Resource-Constraint Settings.
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Sethi, Sidharth Kumar, Bunchman, Timothy, Sarkar, Supratim, Alhasan, Khalid, and Raina, Rupesh
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- 2021
153. Extreme intrafamilial variability of Saudi brothers with primary hyperoxaluria type 1.
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Alfadhel, Majid, Alhasan, Khalid A., Alotaibi, Mohammed, and Al Fakeeh, Khalid
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KIDNEY failure ,OXALATES ,AMINOTRANSFERASES ,BONE biopsy ,SIBLINGS - Abstract
Background: Primary hyperoxaluria type 1 (PH1) is characterized by progressive renal insufficiency culminating in end-stage renal disease, and a wide range of clinical features related to systemic oxalosis in different organs. It is caused by autosomal recessive deficiency of alanine:glyoxylate aminotransferase due to a defect in AGXT gene.Case Report: Two brothers (one 6 months old; the other 2 years old) presented with acute renal failure and urinary tract infection respectively. PH1 was confirmed by high urinary oxalate level, demonstration of oxalate crystals in bone biopsy, and pathogenic homozygous known AGXT gene mutation. Despite the same genetic background, same sex, and shared environment, the outcome of the two siblings differs widely. While one of them died earlier with end-stage renal disease and multiorgan failure caused by systemic oxalosis, the older brother is pyridoxine responsive with normal development and renal function.Conclusion: Clinicians should be aware of extreme intrafamilial variability of PH1 and international registries are needed to characterize the genotype-phenotype correlation in such disorder. [ABSTRACT FROM AUTHOR]- Published
- 2012
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154. Faculty Members' Perspective on Virtual Interviews for Medical Residency Matching during the COVID-19 Crisis: A National Survey.
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Aljamaan, Fadi, Alkhattabi, Fadiah, Al-Eyadhy, Ayman, Alhaboob, Ali, Alharbi, Nasser S., Alherbish, Adi, Almosned, Badr, Alobaylan, Mohammed, Alabdulkarim, Hayfa, Jamal, Amr, Alhaider, Sami A., Alsaywid, Basim, Bashiri, Fahad A., Barry, Mazin, Al-Tawfiq, Jaffar A., Alhasan, Khalid, and Temsah, Mohamad-Hani
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UNIVERSITY faculty ,COVID-19 pandemic ,MEDICAL history taking ,TRAINING of medical residents ,RESIDENTS (Medicine) - Abstract
During the COVID-19 pandemic, conducting face-to-face medical residency interviews was challenging due to infection prevention precautions, social distancing, and travel restrictions. Virtual interviews were implemented by the Saudi Commission for Health Specialties (SCFHS) as an alternative process for residency matching while striving to maintain the same quality standards. This national survey was conducted to assess the satisfaction and perceptions of faculty members' virtual interview performance in the assessment for the medical training residency programs. Among the participating 173 faculty members, 34.1% did not have previous experience with video-conferencing. The Zoom application was the most commonly used platform (65.9%). Most (89.6%) of the faculty perceived virtual interviews as "adequate" platforms on which the candidates could express themselves, while almost half of the faculty (53.8%) agreed that virtual interviews allowed them to accurately reach an impression about the candidates. Overall, 73.4% of faculty felt comfortable ranking the virtually interviewed candidates. We conclude that the acceptance of participating faculty members in the first Saudi medical residency training matching cycle virtual interviewing event was well-perceived. This study provides evidence for future application and research of virtual interviews in residency candidates' assessment, especially after the pandemic crisis resolves. [ABSTRACT FROM AUTHOR]
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- 2022
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155. Reply from the Author.
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Alhasan, Khalid
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AUTHORS - Published
- 2020
156. Multisystemic Inflammatory Syndrome in Children (MIS-C) With COVID-19 and Kidney Involvement: Poor Outcomes in a Case Series.
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Alghamdi, Nora S., Aletani, Lujain, Sandokji, Ibrahim, Aljefri, Hasan, Alhasan, Khalid, Shalaby, Mohammad A., and Kari, Jameela A.
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SARS-CoV-2 , *ADULT respiratory distress syndrome , *COVID-19 , *DISEASE complications , *MULTISYSTEM inflammatory syndrome in children - Abstract
Multisystemic inflammatory syndrome (Mis-C) has emerged in May 2020 as a serious complication of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). A total of 6 children presented to tertiary care hospitals with Mis-C, of which 5 (83%) have died during hospitalization. All included patients presented with respiratory symptoms (ranged from mild to severe acute respiratory distress syndrome) and gastrointestinal symptoms. Most of the patients are known to have medical illnesses. Pediatric Risk of Mortality (PRISM) IV score ranged from 3 to 87. All patients developed acidosis and varying stages of acute kidney injury and electrolyte disturbances. All were treated for coagulopathy, thrombocytopenia, bacterial infections as well as antiviral medications (either ritonavir or lopinavir). Most patients had chest X-ray changes either unilateral or bilateral lung changes. Multisystemic inflammatory syndrome is a rare, yet serious complication of SARS-CoV2 infection in children. Multisystem involvement should be anticipated and promptly treated. [ABSTRACT FROM AUTHOR]
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- 2024
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157. OpenAI o1-Preview vs. ChatGPT in Healthcare: A New Frontier in Medical AI Reasoning.
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Temsah MH, Jamal A, Alhasan K, Temsah AA, and Malki KH
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This editorial explores the recent advancements in generative artificial intelligence with the newly-released OpenAI o1-Preview, comparing its capabilities to the traditional ChatGPT (GPT-4) model, particularly in the context of healthcare. While ChatGPT has shown many applications for general medical advice and patient interactions, OpenAI o1-Preview introduces new features with advanced reasoning skills using a chain of thought processes that could enable users to tackle more complex medical queries such as genetic disease discovery, multi-system or complex disease care, and medical research support. The article explores some of the new model's potential and other aspects that may affect its usage, like slower response times due to its extensive reasoning approach yet highlights its potential for reducing hallucinations and offering more accurate outputs for complex medical problems. Ethical challenges, data diversity, access equity, and transparency are also discussed, identifying key areas for future research, including optimizing the use of both models in tandem for healthcare applications. The editorial concludes by advocating for collaborative exploration of all large language models (LLMs), including the novel OpenAI o1-Preview , to fully utilize their transformative potential in medicine and healthcare delivery. This model, with its advanced reasoning capabilities, presents an opportunity to empower healthcare professionals, policymakers, and computer scientists to work together in transforming patient care, accelerating medical research, and enhancing healthcare outcomes. By optimizing the use of several LLM models in tandem, healthcare systems may enhance efficiency and precision, as well as mitigate previous LLM challenges, such as ethical concerns, access disparities, and technical limitations, steering to a new era of artificial intelligence (AI)-driven healthcare., Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Temsah et al.)
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- 2024
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158. Reference Hallucination Score for Medical Artificial Intelligence Chatbots: Development and Usability Study.
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Aljamaan F, Temsah MH, Altamimi I, Al-Eyadhy A, Jamal A, Alhasan K, Mesallam TA, Farahat M, and Malki KH
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Background: Artificial intelligence (AI) chatbots have recently gained use in medical practice by health care practitioners. Interestingly, the output of these AI chatbots was found to have varying degrees of hallucination in content and references. Such hallucinations generate doubts about their output and their implementation., Objective: The aim of our study was to propose a reference hallucination score (RHS) to evaluate the authenticity of AI chatbots' citations., Methods: Six AI chatbots were challenged with the same 10 medical prompts, requesting 10 references per prompt. The RHS is composed of 6 bibliographic items and the reference's relevance to prompts' keywords. RHS was calculated for each reference, prompt, and type of prompt (basic vs complex). The average RHS was calculated for each AI chatbot and compared across the different types of prompts and AI chatbots., Results: Bard failed to generate any references. ChatGPT 3.5 and Bing generated the highest RHS (score=11), while Elicit and SciSpace generated the lowest RHS (score=1), and Perplexity generated a middle RHS (score=7). The highest degree of hallucination was observed for reference relevancy to the prompt keywords (308/500, 61.6%), while the lowest was for reference titles (169/500, 33.8%). ChatGPT and Bing had comparable RHS (β coefficient=-0.069; P=.32), while Perplexity had significantly lower RHS than ChatGPT (β coefficient=-0.345; P<.001). AI chatbots generally had significantly higher RHS when prompted with scenarios or complex format prompts (β coefficient=0.486; P<.001)., Conclusions: The variation in RHS underscores the necessity for a robust reference evaluation tool to improve the authenticity of AI chatbots. Further, the variations highlight the importance of verifying their output and citations. Elicit and SciSpace had negligible hallucination, while ChatGPT and Bing had critical hallucination levels. The proposed AI chatbots' RHS could contribute to ongoing efforts to enhance AI's general reliability in medical research., (©Fadi Aljamaan, Mohamad-Hani Temsah, Ibraheem Altamimi, Ayman Al-Eyadhy, Amr Jamal, Khalid Alhasan, Tamer A Mesallam, Mohamed Farahat, Khalid H Malki. Originally published in JMIR Medical Informatics (https://medinform.jmir.org), 31.07.2024.)
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- 2024
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159. Virtual Objective Structured Clinical Examination (OSCE) Training in the Pandemic Era: Feasibility, Satisfaction, and the Road Ahead.
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Saeed E, Hamad MH, Alhuzaimi AN, Aljamaan F, Elsenterisi H, Assiri H, Alhasan K, Bashiri FA, Kambal M, Khalil MS, Abdulghani HM, Al-Tawfiq JA, Al-Eyadhy A, and Temsah MH
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Introduction: Objective Structured Clinical Examinations (OSCEs) are essential assessments for evaluating the clinical competencies of medical students. The COVID-19 pandemic caused a significant disruption in medical education, prompting institutions to adopt virtual formats for academic activities. This study analyzes the feasibility, satisfaction, and experiences of pediatric board candidates and faculty during virtual or electronic OSCE (e-OSCE) training sessions using Zoom video communication (Zoom Video Communications, Inc., San Jose, USA)., Methods: This is a post-event survey assessing the perceptions of faculty and candidates and the perceived advantages and obstacles of e-OSCE., Results: A total of 142 participants were invited to complete a post-event survey, and 105 (73.9%) completed the survey. There was equal gender representation. More than half of the participants were examiners. The overall satisfaction with the virtual e-OSCE was high, with a mean score of 4.7±0.67 out of 5. Most participants were likely to recommend e-OSCE to a friend or colleague (mean score 8.84±1.51/10). More faculty (66.1%) than candidates (40.8%) preferred e-OSCE (P=0.006)., Conclusion: Transitioning to virtual OSCE training during the pandemic proved feasible, with high satisfaction rates. Further research on virtual training for OSCE in medical education is recommended to optimize its implementation and outcomes., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institutional Review Board (IRB) at King Saud University, Riyadh, Saudi Arabia issued approval #IRB/8702998-287. Verbal informed consent was acquired from candidates participating in the research. No identifiable data was collected from participants. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Saeed et al.)
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- 2024
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160. Transforming Virtual Healthcare: The Potentials of ChatGPT-4omni in Telemedicine.
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Temsah MH, Jamal A, Alhasan K, Aljamaan F, Altamimi I, Malki KH, Temsah A, Ohannessian R, and Al-Eyadhy A
- Abstract
The introduction of OpenAI's ChatGPT-4omni (GPT-4o) represents a potential advancement in virtual healthcare and telemedicine. GPT-4o excels in processing audio, visual, and textual data in real time, offering possible enhancements in understanding natural language in both English and non-English contexts. Furthermore, the new "Temporary Chat" feature may improve privacy and data confidentiality during interactions, potentially increasing integration with healthcare systems. These innovations promise to enhance communication clarity, facilitate the integration of medical images, and increase data privacy in online consultations. This editorial explores some future implications of these advancements for telemedicine, highlighting the necessity for further research on reliability and the integration of advanced language models with human expertise., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Temsah et al.)
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- 2024
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161. Nutrition in Critically Ill Children with AKI on Continuous RRT: Consensus Recommendations.
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Raina R, Suchan A, Sethi SK, Soundararajan A, Vitale VS, Keller GL, Brown AM, Davenport A, Shih WV, Nada A, Irving SY, Mannemuddhu SS, Crugnale AS, Myneni A, Berry KG, Zieg J, Alhasan K, Guzzo I, Lussier NH, Yap HK, and Bunchman TE
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- Humans, Child, Consensus, Critical Illness therapy, Nutritional Status, Continuous Renal Replacement Therapy, Acute Kidney Injury therapy
- Abstract
Background: Nutrition plays a vital role in the outcome of critically ill children, particularly those with AKI. Currently, there are no established guidelines for children with AKI treated with continuous RRT (CRRT). A thorough understanding of the metabolic changes and nutritional challenges in AKI and CRRT is required. Our objective was to create clinical practice points for nutritional assessment and management in critically ill children with AKI receiving CRRT., Methods: PubMed, MEDLINE, Cochrane, and Embase databases were searched for articles related to the topic. Expertise of the authors and a consensus of the workgroup were additional sources of data in the article. Available articles on nutrition therapy in pediatric patients receiving CRRT through January 2023., Results: On the basis of the literature review, the current evidence base was examined by a panel of experts in pediatric nephrology and nutrition. The panel used the literature review as well as their expertise to formulate clinical practice points. The modified Delphi method was used to identify and refine clinical practice points., Conclusions: Forty-four clinical practice points are provided on nutrition assessment, determining energy needs, and nutrient intake in children with AKI and on CRRT on the basis of the existing literature and expert opinions of a multidisciplinary panel., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology.)
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- 2024
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162. Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study.
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Sethi SK, Wazir S, Sahoo J, Agrawal G, Bajaj N, Gupta NP, Mirgunde S, Balachandran B, Afzal K, Shrivastava A, Bagla J, Krishnegowda S, Konapur A, Sultana A, Soni K, Nair N, Sharma D, Khooblall P, Pandey A, Alhasan K, McCulloch M, Bunchman T, Tibrewal A, and Raina R
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- Hemorrhage complications, Humans, Infant, Newborn, Kidney, Prospective Studies, Registries, Retrospective Studies, Risk Factors, Acute Kidney Injury epidemiology, Acute Kidney Injury etiology, Acute Kidney Injury therapy, Enterocolitis, Necrotizing complications, Heart Diseases complications, Peritoneal Dialysis adverse effects, Water-Electrolyte Imbalance
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Background: Acute kidney injury (AKI) is common in neonates admitted to neonatal intensive care units (NICUs). There is a need to have prospective data on the risk factors and outcomes of acute peritoneal dialysis (PD) in neonates. The use of kidney replacement therapy in this population compared to older populations has been associated with worse outcomes (mortality rates 17-24%) along with a longer stay in the NICU and/or hospital., Methods: The following multicentre, prospective study was derived from the TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) database, assessing all admitted neonates ≤28 days who received intravenous fluids for at least 48 h. The following neonates were excluded: death within 48 h, presence of any lethal chromosomal anomaly, requirement of congenital heart surgery within the first 7 days of life and those receiving only routine care in nursery. Demographic data (maternal and neonatal) and daily clinical and laboratory parameters were recorded. AKI was defined according to the Neonatal Kidney Disease: Improving Global Outcomes criteria., Results: Of the included 1600 neonates, a total of 491 (30.7%) had AKI. Of these 491 neonates with AKI, 44 (9%) required PD. Among neonates with AKI, the odds of needing PD was significantly higher among those with significant cardiac disease (odds ratio (95% confidence interval): 4.95 (2.39-10.27); p < 0.001), inotropes usage (4.77 (1.98-11.51); p < 0.001), severe peripartum event (4.37 (1.31-14.57); p = 0.02), requirement of respiratory support in NICU (4.17 (1.00-17.59); p = 0.04), necrotising enterocolitis (3.96 (1.21-13.02); p = 0.03), any grade of intraventricular haemorrhage (3.71 (1.63-8.45); p = 0.001), evidence of fluid overload during the first 12 h in NICU (3.69 (1.27-10.70); p = 0.02) and requirement of resuscitation in the delivery room (2.72 (1.45-5.12); p = 0.001). AKI neonates with PD as compared to those without PD had a significantly lower median (interquartile range) duration of stay in NICU (7 (4-14) vs. 11 (6-21) days; p = 0.004), but significantly higher mortality (31 (70.5%) vs. 50 (3.2%); p < 0.001). This discrepancy is likely attributable to the critical state of the neonates with AKI., Conclusions: This is the largest prospective, multicentre study specifically looking at neonatal AKI and need for dialysis in neonates. AKI was seen in 30.7% of neonates (with the need for acute PD in 9% of the AKI group). The odds of needing acute PD were significantly higher among those with significant cardiac disease, inotropes usage, severe peripartum event, requirement of respiratory support in NICU, necrotising enterocolitis, any grade of intraventricular haemorrhage, evidence of fluid overload more than 10% during the first 12 h in NICU and requirement of resuscitation in the delivery room. AKI neonates with PD as compared to AKI neonates without PD had a significantly higher mortality. There is a need to keep a vigilant watch in neonates with risk factors for the development of AKI and need for PD.
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- 2022
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163. Parental perceptions and the 5C psychological antecedents of COVID-19 vaccination during the first month of omicron variant surge: A large-scale cross-sectional survey in Saudi Arabia.
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Alenezi S, Alarabi M, Al-Eyadhy A, Aljamaan F, Elbarazi I, Saddik B, Alhasan K, Assiri R, Bassrawi R, Alshahrani F, Alharbi NS, Fayed A, Minhaj Ahmed S, Halwani R, Saad K, Alsubaie S, Barry M, Memish ZA, Al-Tawfiq JA, and Temsah MH
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Background: With the rapid surge of SARS-CoV-2 Omicron variant, we aimed to assess parents' perceptions of the COVID-19 vaccines and the psychological antecedents of vaccinations during the first month of the Omicron spread., Methods: A cross-sectional online survey in Saudi Arabia was conducted (December 20, 2021-January 7, 2022). Convenience sampling was used to invite participants through several social media platforms, including WhatsApp, Twitter, and email lists. We utilized the validated 5C Scale, which evaluates five psychological factors influencing vaccination intention and behavior: confidence, complacency, constraints, calculation, and collective responsibility., Results: Of the 1,340 respondents, 61.3% received two doses of the COVID-19 vaccine, while 35% received an additional booster dose. Fify four percentage were unwilling to vaccinate their children aged 5-11, and 57.2% were unwilling to give the additional booster vaccine to children aged 12-18. Respondents had higher scores on the construct of collective responsibility, followed by calculation, confidence, complacency, and finally constraints. Confidence in vaccines was associated with willingness to vaccinate children and positively correlated with collective responsibility ( p < 0.010). Complacency about COVID-19 was associated with unwillingness to vaccinate older children (12-18 years) and with increased constraints and calculation scores ( p < 0.010). While increasing constraints scores did not correlate with decreased willingness to vaccinate children ( p = 0.140), they did correlate negatively with confidence and collective responsibility ( p < 0.010)., Conclusions: The findings demonstrate the relationship between the five antecedents of vaccination, the importance of confidence in vaccines, and a sense of collective responsibility in parents' intention to vaccinate their children. Campaigns addressing constraints and collective responsibility could help influence the public's vaccination behavior., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Alenezi, Alarabi, Al-Eyadhy, Aljamaan, Elbarazi, Saddik, Alhasan, Assiri, Bassrawi, Alshahrani, Alharbi, Fayed, Minhaj Ahmed, Halwani, Saad, Alsubaie, Barry, COVID-19 Saudi Research Consortium, Memish, Al-Tawfiq and Temsah.)
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- 2022
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164. Acute kidney injury in pediatric hematopoietic cell transplantation: critical appraisal and consensus.
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Raina R, Abu-Arja R, Sethi S, Dua R, Chakraborty R, Dibb JT, Basu RK, Bissler J, Felix MB, Brophy P, Bunchman T, Alhasan K, Haffner D, Kim YH, Licht C, McCulloch M, Menon S, Onder AM, Khooblall P, Khooblall A, Polishchuk V, Rangarajan H, Sultana A, and Kashtan C
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- Child, Consensus, Humans, Transplantation, Autologous adverse effects, Acute Kidney Injury diagnosis, Acute Kidney Injury etiology, Acute Kidney Injury therapy, Hematopoietic Stem Cell Transplantation adverse effects
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Hematopoietic cell transplantation (HCT) is a common therapy for the treatment of neoplastic and metabolic disorders, hematological diseases, and fatal immunological deficiencies. HCT can be subcategorized as autologous or allogeneic, with each modality being associated with their own benefits, risks, and post-transplant complications. One of the most common complications includes acute kidney injury (AKI). However, diagnosing HCT patients with AKI early on remains quite difficult. Therefore, this evidence-based guideline, compiled by the Pediatric Continuous Renal Replacement Therapy (PCRRT) working group, presents the various factors that contribute to AKI and recommendations regarding optimization of therapy with minimal complications in HCT patients., (© 2022. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)
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- 2022
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165. Young Adults With Hereditary Tubular Diseases: Practical Aspects for Adult-Focused Colleagues.
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Alhasan K, D'Alessandri-Silva C, Mongia A, Topaloglu R, Tasic V, and Filler G
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- Adolescent, Adult, Child, Humans, Young Adult, Acidosis, Renal Tubular diagnosis, Acidosis, Renal Tubular genetics, Acidosis, Renal Tubular therapy, Cystinosis diagnosis, Cystinosis genetics, Cystinosis therapy, Diabetes Insipidus, Nephrogenic, Kidney Diseases diagnosis
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Recent advances in the management of kidney tubular diseases have resulted in a significant cohort of adolescents and young adults transitioning from pediatric- to adult-focused care. Most of the patients under adult-focused care have glomerular diseases, whereas rarer tubular diseases form a considerable proportion of pediatric patients. The purpose of this review is to highlight the clinical signs and symptoms of tubular disorders, as well as their diagnostic workup, including laboratory findings and imaging, during young adulthood. We will then discuss more common disorders such as cystinosis, cystinuria, distal kidney tubular acidosis, congenital nephrogenic diabetes insipidus, Dent disease, rickets, hypercalciuria, and syndromes such as Bartter, Fanconi, Gitelman, Liddle, and Lowe. This review is a practical guide on the diagnostic and therapeutic approach of tubular conditions affecting young adults who are transitioning to adult-focused care., (Copyright © 2021 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)
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- 2022
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166. Enhancing parental knowledge of childhood and adolescence safety: An interventional educational campaign.
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Temsah MH, Aljamaan F, Alhaboob A, Almosned B, Alsebail R, Temsah R, Senjab A, Alarfaj A, Aljudi T, Jamal A, Habash A, Alsohime F, Almazyad M, Alabdulhafid M, Hasan G, Assiri RA, Alqahtani WMA, Alherbish A, Alhasan K, and Al-Eyadhy A
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- Adolescent, Adult, COVID-19, Child, Female, Health Promotion, Humans, Male, Middle Aged, SARS-CoV-2, Safety, Saudi Arabia, Accident Prevention, Health Knowledge, Attitudes, Practice, Parents education, Wounds and Injuries prevention & control
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Background: Safeguarding children and adolescents from unintentional injuries is a significant concern for parents and caregivers. With them staying more at home during the coronavirus disease 2019 pandemic, more educational tools and valid educational programs are warranted to improve parental knowledge and awareness about childhood and adolescences' safety. This study aims to explore the effectiveness of childhood and adolescence safety campaigns on parents' knowledge and attitude toward preventable injuries., Methods: This was a pre-post experimental study, in which the predesigned assessments were used as an evaluation tool before and after attending a childhood and adolescence safety campaign. The pre-post assessment question included questions to evaluate the socio-demographic status, followed by knowledge questions in line with the current childhood and adolescence safety campaign. The outcomes of interest were assessed before and after attending the campaign's stations., Results: Three hundred eight parents volunteered to participate in this study. Their knowledge score improved from 36.2 [standard deviation (SD) 17.7] to 79.3 (SD 15.6) after attending the Campaign (t value = 34.6, P < .001). Both, perceptions on the preventability of accidents and the parents' perceived usefulness of educational campaigns showed improvements, with (t value = 6.3, P < .001) and (t value = 3.097, P < .001), respectively., Conclusion: The educational childhood and adolescence safety campaign for caregivers in Saudi Arabia resulted in a significant increase in the overall knowledge and attitudes toward childhood and adolescence's safety. As children and adolescents are currently staying at home more, additional educational tools and programs are warranted to promote safe practices among parents and caregivers., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2022
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167. Importance of clinical practice guidelines to practicing pediatric nephrologists and IPNA survey.
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Hari P, Alhasan K, Bagga A, Bonilla-Felix M, Coccia PA, Duzova A, Ha IS, Montini G, Nakanishi K, Samuel S, Xu H, Boyer O, and Haffner D
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- Cross-Sectional Studies, Humans, Surveys and Questionnaires, Attitude of Health Personnel, Nephrologists psychology, Pediatrics, Practice Guidelines as Topic
- Abstract
Clinical practice guidelines (CPGs) are systematically developed statements backed by scientific evidence to assist practitioners in management in clinical practice. An international cross-sectional survey was conducted by the IPNA to examine the perceptions of pediatric nephrologists on guidelines and their usage and to identify important diseases for future clinical practice guidelines (CPGs). The survey found that the majority of pediatric nephrologists find CPGs useful in clinical practice and admitted to using them most of the time. Developing CPGs is challenging and there are standards available to develop trustworthy guidelines. While evidence-based global guidelines are ideal, pediatric nephrologists expressed the desire that they address regional differences. Most respondents (89.2%) to the survey agreed that adult guidelines did not cover the pediatric perspective adequately and 71.4% opined that consensus-based pediatric guidelines can be developed when evidence for the pediatric population is lacking. The development of high-quality practice guidelines requires substantial resources and may not be feasible in resource-poor countries. Adaptation of an existing guideline has been suggested as an alternative and the ADAPTE collaboration provides a systematic approach to adapting guidelines. Several diseases where pediatric guidelines are needed as a priority including IgA and C3 glomerulopathy were identified in the survey. Implementation of guideline-based care is challenging and the survey found that lack of availability of guidelines (43%) and resources (22.8%) are important reasons for poor implementation in lower-middle and low-income countries. Perceived complexity of guidelines, physician attitudes, and lack of training also contribute to non-adherence to guidelines., (© 2021. IPNA.)
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- 2021
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168. COVID-19 vaccine uptake among healthcare workers in the fourth country to authorize BNT162b2 during the first month of rollout.
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Barry M, Temsah MH, Aljamaan F, Saddik B, Al-Eyadhy A, Alenezi S, Alamro N, Alhuzaimi AN, Alhaboob A, Alhasan K, Alsohime F, Alaraj A, Halwani R, Jamal A, Temsah O, Alzamil F, Somily A, and Al-Tawfiq JA
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- Adult, BNT162 Vaccine, COVID-19 Vaccines, Cross-Sectional Studies, Female, Health Personnel, Humans, Male, SARS-CoV-2, Young Adult, COVID-19, Vaccines
- Abstract
Background: The Kingdom of Saudi Arabia (KSA) was the fourth country in the world to authorize the BNT162b2 coronavirus disease 2019 (COVID-19) vaccine, which it rolled out on December 17, 2020 and first targeted at healthcare workers (HCWs). This study assesses vaccine uptake among this group during the first month of its availability., Methods: A national cross-sectional, pilot-validated, self-administered survey was conducted among HCWs in the KSA between December 27, 2020 and January 3, 2021. The survey included sociodemographic details, previous contact with COVID-19 patients, previous infection with COVID-19, receiving (or registering with the Ministry of Health website to receive) the COVID-19 vaccine, sources of HCWs' information on vaccines, awareness of emerging variants of concern, and anxiety level using the 7-item Generalized Anxiety Disorder assessment. A descriptive bivariate analysis and multivariate logistic binary regression analysis were performed. The primary evaluated outcome was vaccine uptake., Results: Of the 1058 participants who completed the survey, 704 (66.5%) were female, and 626 (59.2%) were nurses. Of all the respondents, 352 (33.27%) were enrolled to receive or had already received the vaccine, while 706 (66.73%) had not enrolled. In a bivariate analysis, not enrolling for vaccination was more likely in females than males (78.5% vs. 21.5%, P < 0.001), HCWs between the ages of 20 and 40 years than those >40 years (70.4% vs. 29.6%, P = 0.005), Saudi HCWs than expatriates (78% vs 22%, P < 0.001), and among HCWs who used social media as a source of information than those who did not (69.8% vs. 38.6%, P < 0.001). In a multivariate analysis, independent factors associated with uptake were being a Saudi national (aOR = 1.918, 95 %CI = 1.363-2.698, P < 0.001), working in an intensive care unit (aOR = 1.495, 95 %CI = 1.083-2.063, P = 0.014), and working at a university hospital (aOR = 1.867, 95 %CI = 1.380-2.525, P < 0.001)., Conclusions: A low level of vaccine uptake was observed especially in female HCWs, those younger than 40 years old, and those who used social media as their source of vaccine information. This survey provides important information for public health authorities in order to scale up vaccination campaigns targeting these HCWs to increase vaccine enrollment and uptake., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2021
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169. Remote interviews for medical residency selection during the initial COVID-19 crisis: a national survey.
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Temsah MH, Alkhattabi F, Aljamaan F, Alhasan K, Alherbish A, Philby M, Alsohime F, Alobaylan M, Alabdulkarim H, Almosned B, Gashgarey D, Felimban G, Alkathiri Z, Almaghrabi R, Jamal A, Barry M, Alhaider SA, Alsaywid B, and Bashiri FA
- Subjects
- Cross-Sectional Studies, Fellowships and Scholarships, Humans, Pandemics, Personnel Selection, SARS-CoV-2, COVID-19, Internship and Residency
- Abstract
Background: Medical training programs candidate's interview is an integral part of the residency matching process. During the coronavirus disease 2019 (COVID-19) pandemic, conducting these interviews was challenging due to infection prevention restrains (social distancing, namely) and travel restrictions. E-interviews were implemented by the Saudi Commission for Healthcare Specialties (SCFHS) since the matching cycle of March 2020 to hold the interviews in a safer virtual environment while maintaining the same matching quality and standards., Aim: This study was conducted to assess the medical training residency program applicants' satisfaction, stress, and other perspectives for the (SCFHS) March 2020 Matching-cycle conducted through an urgently implemented E-interviews process., Method: A cross-sectional, nationwide survey (Additional file 1) was sent to 4153 residency-nominated applicants to the (SCFHS) March 2020 cycle., Results: Among the 510 candidates who responded, 62.2% applied for medical specialties, 20.2% applied for surgical specialties, and 17.6% applied for critical care and emergency specialties. Most respondents (61.2%) never had previous experience with web-based video conferences. Most respondents (80.2%) used the Zoom application to conduct the current E-interviews, whereas only 15.9% used the FaceTime application. 63.3% of the respondents preferred E-interviews over in-person interviews, and 60.6% rated their experience as very good or excellent. 75.7% of the respondents agreed that all their residency program queries were adequately addressed during the E-interviews. At the same time, 52.2% of them agreed that E-interviews allowed them to represent themselves accurately. 28.2% felt no stress at all with their E-interviews experience, while 41.2% felt little stressed and only 8.2% felt highly stressed. The factors that were independently and inversely associated with applicants' level of stress with E-interviews experience were their ability to represent themselves during the interviews (p = 0.001), cost-savings (p < 0.001), their overall rating of the E-interviews quality (p = 0.007) and the speed of the internet connection (p < 0.006)., Conclusion: Videoconferencing was implemented on an urgent basis during the COVID-19 pandemic in the medical residency application process in Saudi Arabia. It was perceived as an adequate and promising tool to replace in-person interviews in the future. Applicants' satisfaction was mainly driven by good organization, cost-saving, and their ability to present themselves. Future studies to enhance this experience are warranted., (© 2021. The Author(s).)
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- 2021
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170. Acute kidney injury in children with COVID-19: a retrospective study.
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Kari JA, Shalaby MA, Albanna AS, Alahmadi TS, Alherbish A, and Alhasan KA
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- Acute Kidney Injury diagnosis, Acute Kidney Injury mortality, Child, Child, Preschool, Creatinine blood, Critical Care, Female, Glomerular Filtration Rate, Humans, Incidence, Length of Stay, Male, Prevalence, Risk Factors, SARS-CoV-2, Systemic Inflammatory Response Syndrome complications, Acute Kidney Injury epidemiology, Acute Kidney Injury virology, COVID-19 complications
- Abstract
Background: Acute kidney injury (AKI) is a complication of coronavirus disease 2019 (COVID-19). The reported incidence of AKI, however, varies among studies. We aimed to evaluate the incidence of AKI and its association with mortality and morbidity in children infected with severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) who required hospital admission., Methods: This was a multicenter retrospective cohort study from three tertiary centers, which included children with confirmed COVID-19. All children were evaluated for AKI using the Kidney Disease Improving Global Outcomes (KDIGO) definition and staging., Results: Of 89 children included, 19 (21 %) developed AKI (52.6 % stage I). A high renal angina index score was correlated with severity of AKI. Also, multisystem inflammatory syndrome in children (MIS-C) was increased in children with AKI compared to those with normal kidney function (15 % vs. 1.5 %). Patients with AKI had significantly more pediatric intensive care admissions (PICU) (32 % vs. 2.8 %, p < 0.001) and mortality (42 % vs. 0 %, p < 0.001). However, AKI was not associated with prolonged hospitalization (58 % vs. 40 %, p = 0.163) or development of MIS-C (10.5 % vs. 1.4 %, p = 0.051). No patient in the AKI group required renal replacement therapy. Residual renal impairment at discharge occurred in 9 % of patients. This was significantly influenced by the presence of comorbidities, hypotension, hypoxia, heart failure, acute respiratory distress, hypernatremia, abnormal liver profile, high C-reactive protein, and positive blood culture., Conclusions: AKI occurred in one-fifth of children with SARS-CoV-2 infection requiring hospital admission, with one-third of those requiring PICU. AKI was associated with increased morbidity and mortality, and residual renal impairment at time of discharge.
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- 2021
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171. Living well with kidney disease.
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McCarthy F, Cochat P, Alhasan K, and Bonilla-Felix M
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- Humans, Quality of Life, Kidney Diseases diagnosis, Kidney Diseases therapy
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- 2021
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172. Coronavirus disease in children: A multicentre study from the Kingdom of Saudi Arabia.
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Kari JA, Shalaby MA, Albanna AS, Alahmadi TS, Sukkar SA, MohamedNur HAH, AlGhamdi MS, Basri AH, Shagal RA, Alnajar A, Badawi M, Safdar OY, Zaher ZF, Temsah MH, and Alhasan KA
- Subjects
- COVID-19 diagnosis, Child, Child, Preschool, Female, Humans, Infant, Male, Retrospective Studies, Saudi Arabia epidemiology, Systemic Inflammatory Response Syndrome, Tertiary Care Centers statistics & numerical data, COVID-19 epidemiology, Hospitalization
- Abstract
Background: The COVID-19 global pandemic caused by severe acute respiratory syndrome coronavirus 2 infection, warranted attention for whether it has unique manifestations in children. Children tend to develop less severe disease with a small percentage present with clinical manifestations of paediatric multisystem inflammatory syndrome and have poor prognosis. We studied the characteristics of COVID-19 in children requiring hospitalisation in the Kingdom of Saudi Arabia and assessed the clinical presentation and the risk factors for mortality, morbidity, and paediatric intensive care (PICU) admission., Methods: We conducted a retrospective analysis of COVID-19 patients under 15 years hospitalised at three tertiary academic hospitals between 1 March and 30 June 2020., Results: Eighty-eight children were enrolled (>20% were infants). Seven (8%) were in critical condition and required PICU admission, and 4 (4.5%) died of which 3 met the full diagnostic criteria of multi-system inflammatory syndrome and had a high Paediatric Risk of Mortality (PRISM) score at the time of admission. The initial polymerase chain reaction (PCR) test result was positive for COVID-19 in most patients (97.7%), and the remaining two patients had positive result in the repeated confirmatory test. In a subset of patients (20 subjects), repeated PCR testing was performed until conversion to negative result, and the average duration for conversion was 8 (95% CI: 5.2-10.5) days Children requiring PICU admission presented with signs of respiratory distress, dehydration, and heart failure. Most had fever (71.4%) and tonsillitis; 61.4% were discharged within 7 days of hospitalisation. Risk factors for mortality included skin rash, hypotension, hypoxia, signs of heart failure, chest radiograph suggestive of acute respiratory distress syndrome, anaemia, leucocytosis, hypernatraemia, abnormal liver enzymes, and high troponin I, and risk factors for prolonged hospitalisation (>7 days) included the presence of comorbidities, leucopaenia, hyponatraemia, and elevated C-reactive protein., Conclusions: The majority of hospitalised children had a brief febrile illness and made a full recovery, but a minority had severe disease., (Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2021
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173. Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation.
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Zhao P, Liu ID, Hodgin JB, Benke PI, Selva J, Torta F, Wenk MR, Endrizzi JA, West O, Ou W, Tang E, Goh DL, Tay SK, Yap HK, Loh A, Weaver N, Sullivan B, Larson A, Cooper MA, Alhasan K, Alangari AA, Salim S, Gumus E, Chen K, Zenker M, Hildebrandt F, and Saba JD
- Subjects
- Adrenal Insufficiency genetics, Aldehyde-Lyases chemistry, Aldehyde-Lyases genetics, Biomarkers metabolism, Fibroblasts drug effects, Humans, Lymphopenia genetics, Mutation, Nephrosis genetics, Phosphates, Syndrome, Adrenal Insufficiency drug therapy, Aldehyde-Lyases metabolism, Dietary Supplements, Lymphopenia drug therapy, Nephrosis drug therapy, Vitamin B 6 administration & dosage
- Abstract
Sphingosine-1-phosphate (S1P) lyase is a vitamin B6-dependent enzyme that degrades sphingosine-1-phosphate in the final step of sphingolipid metabolism. In 2017, a new inherited disorder was described caused by mutations in SGPL1, which encodes sphingosine phosphate lyase (SPL). This condition is referred to as SPL insufficiency syndrome (SPLIS) or alternatively as nephrotic syndrome type 14 (NPHS14). Patients with SPLIS exhibit lymphopenia, nephrosis, adrenal insufficiency, and/or neurological defects. No targeted therapy for SPLIS has been reported. Vitamin B6 supplementation has therapeutic activity in some genetic diseases involving B6-dependent enzymes, a finding ascribed largely to the vitamin's chaperone function. We investigated whether B6 supplementation might have activity in SPLIS patients. We retrospectively monitored responses of disease biomarkers in patients supplemented with B6 and measured SPL activity and sphingolipids in B6-treated patient-derived fibroblasts. In two patients, disease biomarkers responded to B6 supplementation. S1P abundance and activity levels increased and sphingolipids decreased in response to B6. One responsive patient is homozygous for an SPL R222Q variant present in almost 30% of SPLIS patients. Molecular modeling suggests the variant distorts the dimer interface which could be overcome by cofactor supplementation. We demonstrate the first potential targeted therapy for SPLIS and suggest that 30% of SPLIS patients might respond to cofactor supplementation., (© 2020 SSIEM.)
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- 2020
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174. Rituximab versus cyclophosphamide as first steroid-sparing agent in childhood frequently relapsing and steroid-dependent nephrotic syndrome.
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Kari JA, Alhasan KA, Albanna AS, Safdar OY, Shalaby MA, Böckenhauer D, and El-Desoky SM
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- Child, Child, Preschool, Female, Humans, Male, Pilot Projects, Prospective Studies, Remission Induction methods, Cyclophosphamide administration & dosage, Immunosuppressive Agents administration & dosage, Nephrotic Syndrome drug therapy, Rituximab administration & dosage
- Abstract
Background: Approximately 50% of children with steroid-sensitive nephrotic syndrome (SSNS) will suffer from frequent relapses or steroid dependency, prompting the use of so-called steroid-sparing drugs. In this pilot study, we compare the efficacy and safety of rituximab to oral cyclophosphamide as first-line steroid-sparing medications., Methods: A prospective open-label non-randomized study of children with frequent relapsing or steroid-dependant SSNS. Exclusion criteria were steroid-resistant disease, prescription of immunosuppressive agents other than prednisolone or levamisole, evidence of impaired kidney function, leucopenia, or active infection. The recruited children were allocated either to the oral cyclophosphamide (3 mg/kg/day for 8 weeks) or intravenous rituximab treatment (two doses of 375 mg/m
2 /dose, 2 weeks apart) and were monitored for relapses and side effects for 12 months., Results: Forty-six subjects were included from two centers; 27 received cyclophosphamide and 19 received rituximab. One-year relapse-free survival was reached in 17 (58.6%) patients treated with cyclophosphamide compared to 16 (84.2%) with rituximab (adjusted HR 0.36; 95% CI 0.09-1.45; p = 0.151). The mean interval to relapse was 6.9 months in the cyclophosphamide group (N = 10) and 6.3 months in the rituximab group (N = 3). Both treatments were associated with a significant (p < 0.001) reduction in prescribed dose of oral alternate-day steroid from 1.02 to 0.36 mg/kg (cyclophosphamide) and 0.86 to 0.08 mg/kg (rituximab). Importantly, a significantly (p = 0.003) higher percentage of patients achieved complete withdrawal of steroid within 3 months of commencing study treatment in the rituximab (73.7%) versus cyclophosphamide (29.6%) group. Transient leucopenia was the most frequent adverse effect observed in the cyclophosphamide group (18.5%) and one patient (3.4%) had acute hepatotoxicity besides severe leucopenia and neutropenia in the 7th week of treatment with complete recovery with the withdrawal of cyclophosphamide and maintenance of remission. A minor infusion-related reaction in the form of a generalized macular skin rash was observed in one patient (5%) in the rituximab group., Conclusions: Rituximab is non-inferior to cyclophosphamide and safe as a first-line steroid-sparing agent in children with SSNS. A larger multicenter study is required to assess superiority over cyclophosphamide. Graphical abstract.- Published
- 2020
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175. Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.
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Raina R, Bedoyan JK, Lichter-Konecki U, Jouvet P, Picca S, Mew NA, Machado MC, Chakraborty R, Vemuganti M, Grewal MK, Bunchman T, Sethi SK, Krishnappa V, McCulloch M, Alhasan K, Bagga A, Basu RK, Schaefer F, Filler G, and Warady BA
- Subjects
- Arginine therapeutic use, Carnitine therapeutic use, Child, Child, Preschool, Delphi Technique, Diet, Protein-Restricted, Humans, Hybrid Renal Replacement Therapy, Hyperammonemia metabolism, Infant, Infant, Newborn, Parenteral Nutrition methods, Phenylacetates therapeutic use, Phenylbutyrates therapeutic use, Practice Guidelines as Topic, Renal Dialysis methods, Sodium Benzoate therapeutic use, Urea Cycle Disorders, Inborn metabolism, Vitamin B Complex therapeutic use, Continuous Renal Replacement Therapy methods, Hyperammonemia therapy, Peritoneal Dialysis methods, Urea Cycle Disorders, Inborn therapy
- Abstract
Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in neonates and children. Moreover, consensus guidelines are lacking for the use of non-kidney replacement therapy (NKRT) and kidney replacement therapies (KRTs, including peritoneal dialysis, continuous KRT, haemodialysis and hybrid therapy) to manage hyperammonaemia in neonates and children. Prompt treatment with KRT and/or NKRT, the choice of which depends on the ammonia concentrations and presenting symptoms of the patient, is crucial. This expert Consensus Statement presents recommendations for the management of hyperammonaemia requiring KRT in paediatric populations. Additional studies are required to strengthen these recommendations.
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- 2020
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176. Correction to: Short-term outcome associated with disease severity and electrolyte abnormalities among critically ill children with acute kidney injury.
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Safdar OY, Alhasan KA, Shalaby MA, Khathlan N, Al Rezgan SA, Albanna AS, and Kari JA
- Abstract
Following publication of the original article [1].
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- 2020
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177. Genetics of congenital and infantile nephrotic syndrome.
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Sharief SN, Hefni NA, Alzahrani WA, Nazer II, Bayazeed MA, Alhasan KA, Safdar OY, El-Desoky SM, and Kari JA
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- Academic Medical Centers, Age Distribution, China, Cohort Studies, Combined Modality Therapy, Disease Progression, Female, Genetic Testing methods, Humans, Infant, Infant, Newborn, Kidney Failure, Chronic epidemiology, Kidney Failure, Chronic physiopathology, Male, Membrane Proteins genetics, Mutation, Nephrotic Syndrome diagnosis, Nephrotic Syndrome epidemiology, Prevalence, Prognosis, Retrospective Studies, Risk Assessment, Sex Distribution, Genetic Predisposition to Disease epidemiology, Intracellular Signaling Peptides and Proteins genetics, Nephrotic Syndrome genetics, Nephrotic Syndrome therapy
- Abstract
Background: Congenital and infantile nephrotic syndrome (CNS and INS) are rare inherited defects in glomerular filtration involving a variety of gene mutations. This study aimed to analyze all genetic mutations associated with congenital and infantile nephrotic syndrome treated at our institution. We also discussed our different approach secondary to culture and resources., Methods: A retrospective single-center study of all children diagnosed as NS before the age of 1 year over a duration of over one decade., Results: Twenty-nine children (12 boys) were included in the study. Their median age (range) was 2.4 (0.1-12) months (20 CNS and 9 INS). Consanguinity was present in 90% of children. The genetic analysis' results were only available for 20 children. An underlying causative homozygous mutation was detected in 18 children (90%): NPHS1 (9), NPHS2(2), LAMB2(3), PLCE1(1), WT1(1), and ITSN1 novel mutation (2). One child had heterozygous mutation of NPHS2 and another child had heterozygous mutation of NPHS1 which could not explain the disease. All CNS cases were all managed with intermittent intravenous albumin infusion, ACEi, diuretics, and indomethacin. None of the children were managed by nephrectomy followed by peritoneal dialysis (PD) because of limited resources. Only one child achieved partial remission, while 15 children died at a median (range) age of 5.8 (1.25-29) months. The remaining 14 children were followed up for an average of 36 (3.9-120) months. Three children progressed to end-stage kidney disease and PD was performed in only two children., Conclusions: NPHS1 is the main underlying cause of CNS and INS in our study population. CNS and INS were associated with high morbidity and mortality.
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- 2019
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178. Short-term outcome associated with disease severity and electrolyte abnormalities among critically ill children with acute kidney injury.
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Safder OY, Alhasan KA, Shalaby MA, Khathlan N, Al Rezgan SA, Albanna AS, and Kari JA
- Subjects
- Acute Kidney Injury epidemiology, Child, Preschool, Cohort Studies, Female, Humans, Male, Prospective Studies, Time Factors, Treatment Outcome, Acute Kidney Injury blood, Acute Kidney Injury diagnosis, Critical Illness epidemiology, Intensive Care Units, Pediatric trends, Severity of Illness Index, Water-Electrolyte Balance physiology
- Abstract
Background: Acute kidney injury (AKI) in critically ill children is associated with increased mortality and morbidity. In this study we evaluated the effect of AKI severity on the incidence of short-term mortality and morbidity., Methods: Multicenter prospective cohort study was conducted over two years period. We used the Kidney Disease Improving Global Outcomes (KDIGO) to diagnose and stage AKI., Results: A total of 511 out of 1367 included children (37.4%; 95% CI: 34.8-40.0) were diagnosed with AKI. They were categorized into three KDIGO stages: stage I (mild) in 47.5% (95% CI: 43.2-52.0), stage II (moderate) in 32.8% (95% CI: 28.8-37.1) and stage III (severe) in 19.7% (95% CI: 16.4-23.5). Stage II and III AKI had higher risk of mortality and longer length of stay (LOS) in hospital. Children with stage III AKI were more likely to require mechanical ventilation, referral to pediatric nephrology and discharge with abnormal creatinine level (above 100 uml\L). Hypervolemia, hypocalcemia, anemia, and acidosis were found to be independent risk factors of mortality., Conclusion: The extent of severity of AKI is directly associated with increased mortality, LOS and short-term morbidity.
- Published
- 2019
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179. Urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C measurements for early diagnosis of acute kidney injury in children admitted to PICU.
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Kari JA, Shalaby MA, Sofyani K, Sanad AS, Ossra AF, Halabi RS, Aljuhani MH, Toffaha WM, Moria FA, Sabry S, Ahmed HA, Alhasan KA, Sharief S, and Safdar O
- Subjects
- Acute Kidney Injury epidemiology, Adolescent, Child, Child, Preschool, Cohort Studies, Developing Countries, Early Diagnosis, Female, Humans, Incidence, Infant, Infant, Newborn, Male, Prospective Studies, Risk Assessment, Saudi Arabia epidemiology, Sensitivity and Specificity, Severity of Illness Index, Acute Kidney Injury diagnosis, Biomarkers analysis, Cystatin C blood, Intensive Care Units, Pediatric, Lipocalin-2 urine
- Abstract
Background: Acute kidney injury (AKI) is common in critically ill children with significant mortality and morbidity. Serum creatinine is an insensitive and late biomarker compared to newly proposed AKI biomarkers., Methods: Prospective study in pediatric intensive care unit (PICU) over three months to compare between serum cystatin-C (s-Cys-C) and urinary neutrophil gelatinase-associated lipocalin (uNGAL) as AKI biomarkers at multiple time points with pediatric risk, injury, failure, loss, end-stage renal disease (pRIFLE) classification in diagnosing AKI., Results: Forty children were recruited. Of these 40 children, 22 developed AKI according to pRIFLE criteria. There was no significant difference between AKI and non-AKI in age (P = 0.29). Post cardiac surgery, renal insult was the main cause of AKI (27.3%). There was a twofold increased risk of incident AKI in those patients with high baseline uNGAL at PICU admission and almost a fourfold increased risk in patients with high baseline s-Cys-C at PICU admission. uNGAL levels were highly predictive of AKI during the follow-up period [area under the curve (AUC) = 0.76, 95% confidence interval (CI) 0.61-0.92]. The cutoff point with the highest correctly classified proportion was 223 ng/mL (≥ 12 centiles) which correctly predict 80.0% patients with AKI, with a corresponding sensitivity of 72.7% and a specificity of 89.9%. AUC for s-Cys-C was 0.86 (95% CI 0.75-0.97), and the highest correctly classified proportion was 1009 µg/L (≥ 13 centiles); 75% of patients with AKI, with a corresponding sensitivity of 63.6% and a specificity of 88.9%., Conclusion: uNGAL and s-Cys-C predicts AKI early in critically ill children.
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- 2018
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180. Outcome of pediatric acute kidney injury: a multicenter prospective cohort study.
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Kari JA, Alhasan KA, Shalaby MA, Khathlan N, Safdar OY, Al Rezgan SA, El Desoky S, and Albanna AS
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- Child, Child, Preschool, Cohort Studies, Female, Hospital Mortality, Humans, Infant, Intensive Care Units, Pediatric statistics & numerical data, Length of Stay statistics & numerical data, Male, Prospective Studies, Risk Factors, Acute Kidney Injury epidemiology
- Abstract
Background: Acute kidney injury (AKI) is a common problem encountered in critically ill children with an increasing incidence and evolving epidemiology. AKI carries a serious morbidity and mortality in patients requiring admission to a pediatric intensive care unit (PICU)., Methods: We undertook a prospective cohort study of PICU admissions at three tertiary care hospitals in the Kingdom of Saudi Arabia over 2 years. The Kidney Disease Improving Global Outcomes (KDIGO) definition was used to diagnose AKI., Results: A total of 1367 pediatrics PICU admissions were included in the study. AKI affected 511 children (37.4%), with 243 children (17.8%) classified as stage I (mild), 168 patients (12.3%) stage II (moderate), and 100 children (7.3%) were classified as stage III (severe). After adjustment for age, sex, and underlying diagnosis, in-hospital mortality was six times more likely among patients with AKI as compared to patients with normal renal function (adjusted OR: 6.5, 95% CI: 4.2-10). AKI was also a risk factor for hypertension (adjusted OR: 4.1, 95% CI: 2.8-5.9) and prolonged stay in the PICU and hospital, as it increased the average number of admission days by 10 (95% CI: 8.6-11) days in the PICU and 12 (95% CI: 10-14) days in the hospital., Conclusions: One-third of PICU admissions were complicated with AKI. AKI was associated with increased hospital mortality and the length of stay in both PICU and hospital.
- Published
- 2018
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