351. P2-302 Nocturnal intermittent hypoxia and cardiovascular risk factors in community-dwelling Japanese: the Circulatory Risk in Communities Study (CIRCS)
- Author
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Hiroyasu Iso, Takeshi Tanigawa, Hironori Imano, Kazumasa Yamagishi, S. Sato, T Ohira, Susumu Sakurai, Akihiko Kitamura, M Kiyama, and Isao Muraki
- Subjects
medicine.medical_specialty ,Epidemiology ,Cross-sectional study ,business.industry ,Public Health, Environmental and Occupational Health ,Intermittent hypoxia ,Type 2 diabetes ,medicine.disease ,Endocrinology ,Internal medicine ,medicine ,Sleep study ,Metabolic syndrome ,business ,Prospective cohort study ,Cohort study - Abstract
Introduction To investigate whether nocturnal intermittent hypoxia (NIH), a surrogate marker for sleep apnoea, is associated with cardiovascular risk factors, we conducted epidemiological studies. Methods The CIRCS is a prospective cohort study across Japan since 1963 to examine risk factors for cardiovascular disease. Subjects aged 40–69 years were recruited to the sleep study in three communities. NIH was estimated by hourly occurrences of oxygen desaturation of ≥3% (3% oxygen desaturation index [3% ODI]) by a pulse-oximeter during a night9s sleep in the participant9s own home. We defined no, mild and moderate-to-severe NIH by 3% ODI as Results Compared with no NIH, the multivariable OR of hypertension was 1.63 (95% CI 1.1 to 2.5) for moderate-to-severe NIH. The prevalence of a high CRP (≥1.0 mg/l) was 1.4 to 1.7-fold higher for mild to severe NIH in both sexes. The multivariable ORs of metabolic syndrome was 3.2 (2.2 to 4.7) for moderate-to-severe NIH among men and 5.8 (3.4 to 9.8) among women, respectively. The multivariable-adjusted HRs of developing type 2 diabetes was 1.3 (0.9 to 1.8) among those with mild NIH and 1.7 (1.0 to 2.8) among those with moderate-to-severe NIH. Conclusion NIH was associated with hypertension, elevated serum CRP levels, the accumulation of metabolic risk factors, and increased risk of developing type 2 diabetes among middle-aged Japanese.
- Published
- 2011