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This document is a correction notice for an article titled "CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4" published in Cellular & Molecular Neurobiology. The correction addresses an error in Figure 10 of the original article, specifically the merge image of microglia stained with CD206. The corrected figure is provided, and the authors apologize for any inconvenience caused. The publisher, Springer Nature, remains neutral regarding jurisdictional claims and institutional affiliations. [Extracted from the article]

This paper examines the intra-firm transfer of tacit and explicit knowledge in the post-acquisition integration stage in the outward mergers and acquisitions (M&A) of multinational corporations from emerging economies (EMNCs). It also explores rationales underlying the tacit and explicit knowledge transfer in the cross-cultural context. Drawing from the empirical evidence of three Chinese firms’ outward M&A in three European countries, we argue the Chinese acquiring firms emphasized the transfer of explicit over tacit knowledge in the post-acquisition integration in their outward M&A. This can be attributed to complementarity in explicit knowledge, home market advantage, scarcity of key staff and cultural differences. [ABSTRACT FROM AUTHOR]

Purpose: To identify primary sites of nasopharyngeal carcinoma (NPC) invasion on the staging head and neck magnetic resonance imaging (MRI) that correlate with distant metastases (DM).Materials and methods: Staging head and neck MRI examinations of 579 NPC patients were assessed for primary tumour invasion into 16 individual sites, primary stage (T) and nodal stage (N). Results were correlated with distant metastasis-free survival (DMFS) using the Cox regression, and the diagnostic performance of significant independent markers for DM was calculated. In addition, sites of primary tumour invasion were correlated also with involvement of the first echelon of ipsilateral nodes (FEN+) using logistic regression.Results: Distant metastases were present in 128/579 NPC patients (22.1%) after intensity-modulated radiotherapy (IMRT)/chemo-IMRT and 5-year DMFS was 78.8%. Prevertebral space invasion (PVS+) and N stage, but not T stage, were independent prognostic markers of DMFS (p = 0.016, < 0.001, and 0.433, respectively). Compared to stage N3, PVS invasion had a higher sensitivity (28.1 vs. 68.8%), but lower specificity (90.5 vs. 47.4%) and accuracy (76.7 vs. 48.9%) for correlating patients with DM. PVS invasion, together with parapharyngeal fat space invasion (PPFS+), was also an independent predictive marker of FEN+.Conclusion: PVS was the only site of primary tumour invasion that independently correlated with DM, and together with PPFS + was an independent prognostic marker of FEN+, but the low specificity and accuracy of PVS invasion limits its use as a prognostic marker of DM. [ABSTRACT FROM AUTHOR]

A pounding tuned mass damper (PTMD) can be considered as a passive device, which combines the merits of a traditional tuned mass damper (TMD) and a collision damper. A recent analytical study by the authors demonstrated that the PTMD base on the energy dissipation during impact is able to achieve better control effectiveness over the traditional TMD. In this paper, a PTMD prototype is manufactured and applied for seismic response reduction to examine its efficacy. A series of shaking table tests is conducted in a three-story building frame model under single-dimensional and two-dimensional broadband earthquake excitations with different excitation intensities. The ability of the PTMD to reduce the structural responses is experimentally investigated. The results show that the traditional TMD is sensitive to input excitations, while the PTMD mostly has improved control performance over the TMD to remarkably reduce both the peak and root-mean-square (RMS) structural responses under single-dimensional earthquake excitation. Unlike the TMD, the PTMD is found to have the merit of maintaining a stable performance when subjected to different earthquake loadings. In addition, it is also indicated that the performance of the PTMD can be enhanced by adjusting the initial gap value, and the control effectiveness improves with the increasing excitation intensity. Under two-dimensional earthquake inputs, the PTMD controls remain outperform the TMD controls; however, the oscillation of the added mass is observed during the test, which may induce torsional vibration modes of the structure, and hence, result in poor control performance especially after a strong earthquake period. [ABSTRACT FROM AUTHOR]

We previously conducted a prospective study to show that nasopharyngeal cancer (NPC) screening with circulating Epstein-Barr virus (EBV) DNA analysis can improve survival. However, the long-term significance of positive results in individuals without cancer was unclear. We conducted a second-round screening at a median of 43 months after the initial screening. Participants with detectable plasma EBV DNA were retested in 4 weeks, and those with persistently positive results were investigated with nasal endoscopy and magnetic resonance imaging. Of the 20,174 volunteers who participated in the first-round screening, 17,838 (88.6%) were rescreened. Among them, 423 (2.37%) had persistently detectable plasma EBV DNA. Twenty-four patients were identified as having NPC. A significantly higher proportion of patients had stage I/II cancer than in a historical cohort (67% vs. 20%; chi-square test, P<0.001), and they had superior 3-year progression-free survival (100% vs. 78.8%). Compared with participants with undetectable plasma EBV DNA in the first round of screening, participants with transiently and persistently positive results in the first round were more likely to have a cancer identified in the second round, with relative risks of 4.4 (95% confidence interval, 1.3 to 15.0) and 16.8 (95% confidence interval, 5.7 to 49.6), respectively. Individuals with detectable plasma EBV DNA but without an immediately identifiable NPC were more likely to have the cancer identified in another round of screening performed 3 to 5 years later. (Funded by Kadoorie Charitable Foundation and others; ClinicalTrials.gov number, NCT02063399.) [ABSTRACT FROM AUTHOR]

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease in ageing individuals. Current therapeutic regimen suffers from general side effects and a poor efficiency for PD symptoms. The need for development new therapeutic agents for PD is urgent. Here, we aimed to explore the metabolic mechanism of PD and identified potential novel agents for PD by a sub-pathway-based method. By using the GSE7621 microarray data from the GEO database, we first identified the 1226 differentially expressed genes (DEGs) between PD and normal samples. Then we identified 19 significant enriched metabolic sub-pathways, which may involve in development of PD. Finally, by an integrated analysis of PD-involved sub-pathways and drug-affected sub-pathways, we identified 49 novel small molecular drugs capable to target the PD-involved sub-pathways. Our method could not only identify existing drug (apomorphine) for PD, but also predict potentially novel agents (ketoconazole and astemizole), which might have therapeutic effects via targeting some key enzymes in arachidonic acid metabolism. These candidate agents identified by our approach may provide insights into a novel therapy approach for PD. [ABSTRACT FROM AUTHOR]

A series of 'turn-on' fluorescence diarylethenes derived from 2,3-bis(2-methylbenzo[ b]thiophen-3-yl)-5,6-dihydro-4 H-thieno[2,3- b]thiopyran-4-one ( 1) with alkyl and acetyl substituents were synthesized. The photochemical and photophysical properties of these derivatives, including the photoreaction of crystalline 1, were thoroughly investigated to reveal substituent effects on their properties. The results indicated that alkyl substituents did not significantly affect the absorption and emission spectra of the diarylethenes. However, large absorption and emission wavelength shifts were observed for the diarylethene with an acetyl substituent due to extension of π-π conjugation. Significantly, all of the fluorescent ring-closed forms of the compounds isomerized to their ring-open forms in the presence of Cu2+ in the dark. EPR results provide clear evidence for the formation of the compound 1 radical cation intermediate that might be generated in the reaction between c- 1 and Cu2+. DFT calculations found that the ground-state activation energy for ring-opening of 1.+ was approximately 9.2 kcal mol−1 lower than that of 1 without Cu2+, such that a Cu2+-catalyzed oxidative cycloreversion reaction at room temperature might be possible. [ABSTRACT FROM AUTHOR]

Background: Toxin‐antitoxin systems are highly variable, even among strains of the same bacterial species. The MazEF toxin‐antitoxin system is found in many bacteria and plays important roles in various biological processes such as antibiotic tolerance and phage defense. However, no interplay of MazEF systems between different species was reported. Materials and Methods: MazEF toxin‐antitoxin system of Helicobacter macacae was examined in three Escherichia coli strains with and without endogenous MazEF knockout. In vivo toxicity, antibiotic tolerance, and live/dead staining followed by flowcytometry analysis were performed to evaluate the functionality and interplay of the toxin‐antitoxin system between the two species. Results: Controlled ectopic expression of MazF of H. macacae (MazFhm) in E. coli did not affect its growth. However, in endogenous MazEF knockout E. coli strains, MazFhm expression caused a sharp growth arrest. The toxicity of MazFhm could be neutralized by both the antitoxin of MazE homolog of H.macacae and the antitoxin of MazE of E. coli, indicating interplay of MazEF toxin‐antitoxin systems between the two species. Induced expression of MazFhm enhanced tolerance to a lethal dose of levofloxacin, suggesting enhanced persister formation, which was further confirmed by live/dead cell staining. Conclusions: The MazEF toxin‐antitoxin system of H. macace enhances persister formation and thus antibiotic tolerance in E. coli. Our findings reveal an interplay between the MazEF systems of H. macacae and E. coli, emphasizing the need to consider this interaction while evaluating the toxicity and functionality of MazF homologs from different species in future studies. [ABSTRACT FROM AUTHOR]