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354. Cicletanine improves myocardial function deteriorated by ischemia/reperfusion in isolated working rat hearts

Author

Thierry Tarrade, Péter Ferdinandy, Matyas Koltai, Arpad Tosaki, Pierre Braquet, Andre Esanu, and P. Berthet

Subjects
Cardiac function curve, Male, medicine.medical_specialty, medicine.drug_class, Pyridines, Ischemia, Coronary Disease, Myocardial Reperfusion, Calcium channel blocker, Coronary circulation, Nitrendipine, Heart Rate, Internal medicine, Coronary Circulation, medicine, Animals, Diuretics, Antihypertensive Agents, Pharmacology, Cicletanine, business.industry, Gyógyszerészeti tudományok, Dihydropyridine, Arrhythmias, Cardiac, Rats, Inbred Strains, Orvostudományok, medicine.disease, Rats, Perfusion, medicine.anatomical_structure, Coronary occlusion, Cardiology, Cardiology and Cardiovascular Medicine, business, Anti-Arrhythmia Agents, medicine.drug
Abstract

The effect of cicletanine, a novel furopyridine antihypertensive drug was compared with that of nitrendipine, a dihydropyridine slow calcium channel blocker, on cardiac function and reperfusion-induced ventricular arrhythmias in isolated working rat hearts subjected to 10-min ischemia induced by ligation of the left main coronary artery followed by 10-min reperfusion. Before ischemia, cicletanine and nitrendipine, perfused at concentrations of 3 x 10(-5), 6 x 10(-5), 10(-4), and 2 x 10(-4) or 10(-8) M, respectively, did not influence heart rate (HR), LV developed pressure (LVDP), its first derivative (LVdP/dtmax), and LV end-diastolic pressure (LVEDP), whereas aortic flow (AF) was decreased by 2 x 10(-4) M cicletanine only. Coronary flow (CF) remained unchanged by various cicletanine concentrations but was slightly increased by nitrendipine. In the concentration range of 3 x 10(-5)-10(-4) M, cicletanine improved AF either in ischemia or during reperfusion, whereas 2 x 10(-4) M had no such effect. Nitrendipine slightly attenuated ischemia/reperfusion-induced decrease in AF. Cicletanine and nitrendipine enhanced LVDP during ischemia. Ischemia-induced deterioration of LVdP/dtmax was reduced by cicletanine, during reperfusion, but this parameter was reduced by nitrendipine and the highest cicletanine concentration. Cicletanine decreased LVEDP significantly during ischemia and reperfusion, but nitrendipine had no such effect. All cicletanine concentrations reduced the incidence of irreversible ventricular fibrillation (VF) during reperfusion, an effect roughly concentration dependent in the range of 3 x 10(-5)-10(-4) M, whereas nitrendipine had no influence on arrhythmias.

Published
1992

355. PAF-acether induced arterial thrombosis and the effect of specific antagonists

Author

R H, Bourgain, R, Andries, A, Esanu, and P, Braquet

Subjects
Blood Platelets, Thienopyridines, Hydrolases, Guinea Pigs, Down-Regulation, Thrombosis, Azepines, Hydrogen Peroxide, Triazoles, Mesenteric Arteries, Phenylmethylsulfonyl Fluoride, Acetyltransferases, Animals, Platelet Activating Factor
Abstract

Platelet-vessel wall interactions and local thrombosis are investigated in vivo in a branch of the mesenteric artery of the guinea pig, using optoelectronic registration and ultrastructural control. Following an electrical challenge resulting in changes of cell membrane polarization, subsequent superfusion by PAF-acether or a stable analogue, (1-O-alkyl-2-N-methylcarbamyl-sn-glycero-3-phosphocholine, 10(-8) M focal concentration (f.c.)) for a restricted period results in endothelial cell retraction and bleb formation followed by platelet adhesion and the development of a thrombus which over time becomes invaded by leukocytes and eventually occludes the vascular lumen. It was demonstrated in a previous investigation that these phenomena are triggered by the generation of endogenous PAF-acether by the endothelial cells. Specific PAF-acether-antagonists, such as BN 52021 a ginkgolide, but also synthetic molecules, derivatives of the triazolo-pyridino-diazepine group (BN 50727, BN 50755 and BN 50789), significantly inhibit platelet-vessel wall interactions and thrombosis, but not the formation of blebs in the endothelial cells. Hydrogen peroxide (10(-5)M f.c.) not only primes the effect of PAF-acether, but is by itself capable of inducing thrombosis through a PAF-acether-mediated mechanism. Inhibition of acetyl hydrolase by PMSF (phenyl-methyl-sulfonyl-fluoride, 10(-5)M f.c.) invariably results in a significant enhancement of thrombosis, while conversely, inhibition of acetyl transferase by 27584 RP (4-(naphtylvinyl)pyridine hydrochloride, 10(-6)M f.c.) inhibits thromboformation indicating that the remodeling pathway is involved.

Published
1992

356. PAF-Acether Induced Arterial Thrombosis and the Effect of Specific Antagonists

Author

Pierre Braquet, Roger Andries, Andre Esanu, and René Bourgain

Subjects
Endothelial stem cell, Cell membrane, chemistry.chemical_compound, medicine.anatomical_structure, Platelet-activating factor, Chemistry, In vivo, medicine, Platelet, Bleb (cell biology), PMSF, Pharmacology, Mesenteric arteries
Abstract

Platelet-vessel wall interactions and local thrombosis are investigated in vivo in a branch of the mesenteric artery of the guinea pig, using optoelectronic registration and ultrastructural control. Following an electrical challenge resulting in changes of cell membrane polarization, subsequent superfusion by PAF-acether or a stable analogue, (1-O-alkyl-2-N-methylcarbamyl-sn-glycero-3-phosphocholine, 10(-8) M focal concentration (f.c.)) for a restricted period results in endothelial cell retraction and bleb formation followed by platelet adhesion and the development of a thrombus which over time becomes invaded by leukocytes and eventually occludes the vascular lumen. It was demonstrated in a previous investigation that these phenomena are triggered by the generation of endogenous PAF-acether by the endothelial cells. Specific PAF-acether-antagonists, such as BN 52021 a ginkgolide, but also synthetic molecules, derivatives of the triazolo-pyridino-diazepine group (BN 50727, BN 50755 and BN 50789), significantly inhibit platelet-vessel wall interactions and thrombosis, but not the formation of blebs in the endothelial cells. Hydrogen peroxide (10(-5)M f.c.) not only primes the effect of PAF-acether, but is by itself capable of inducing thrombosis through a PAF-acether-mediated mechanism. Inhibition of acetyl hydrolase by PMSF (phenyl-methyl-sulfonyl-fluoride, 10(-5)M f.c.) invariably results in a significant enhancement of thrombosis, while conversely, inhibition of acetyl transferase by 27584 RP (4-(naphtylvinyl)pyridine hydrochloride, 10(-6)M f.c.) inhibits thromboformation indicating that the remodeling pathway is involved.

Published
1992

358. Evidence for a sulfo-conjugate as active metabolite of cicletanine

Author

R P, Garay, C, Rosati, C, Nazaret, A, Esanu, P, Berthet, T, Tarrade, and P, Braquet

Subjects
Erythrocytes, Pyridines, Sulfates, Natriuresis, Muscle, Smooth, Vascular, Diuresis, Rats, Ion Exchange, Bicarbonates, Chlorides, Animals, Humans, Diuretics, Antihypertensive Agents, Cells, Cultured
Published
1991

360. Platelet activating factor (PAF). A review of its effects, antagonists and possible future clinical implications (Part I)

Author

M, Koltai, D, Hosford, P, Guinot, A, Esanu, and P, Braquet

Subjects
Blood Cells, Hemodynamics, Animals, Humans, Platelet Activating Factor
Abstract

This review is an attempt to summarise recent data on platelet activating factor (PAF) and PAF antagonists from 1988 to the present. This period saw a burst in research activity focused predominantly on the effect of PAF in various organs. The effect of PAF and its antagonists was further intensively studied in vitro on isolated platelets, leucocytes, macrophages and endothelial cells. From these and earlier data, based on the catastrophe theory of Thom and Zeeman, a new concept on the interaction between PAF and various cytokines could be recognised as an important mechanism of action of the phospholipid mediator, suggesting the existence of an autocatalytic feedback network through which PAF can influence cellular function under certain pathophysiological conditions. This mechanism can be regarded as the culmination of our recent knowledge on the role of PAF, and may influence the possible clinical implications of PAF antagonists in the near future. It is recognised that PAF is released in shock and ischaemic states, and that PAF antagonists can protect the heart and brain against ischaemic injury. Therefore, in contrast to the previous period, which was predominantly devoted to the elucidation of the role of PAF in immediate hypersensitivity reactions, studies performed on cerebral, myocardial and intestinal ischaemia as well as in various shock conditions have concentrated on entirely new aspects of the effect of PAF antagonists, emphasising the significance of the inflammatory process and cell-to-cell interactions in these pathophysiological states. This has led to a re-evaluation of the experimental data previously accumulated. At the same time, these new trends in PAF and PAF antagonist research have explored further possibilities for the application of PAF antagonists in clinical practice. Attention has been focused on the physiological role of PAF as a signal molecule, especially between the neuroendocrine system and related sensory organs. The recognition of the significance of PAF in mammalian reproduction is fascinating and may lead to new clinical applications of PAF antagonists. It appears probable that, like eicosanoids, PAF is involved in a great variety of membrane-dependent processes that play a fundamental role in the maintenance of homeostasis. PAF research has provided several potent natural and synthetic antagonists which may facilitate the clinical application of these drugs in the near future.

Published
1991

361. DENTAL IMPLICATIONS OF THE NEW ORAL ANTICOAGULANTS.

Author

Paraschiv, Cringuta, Esanu, Irina, Ghiuru, Rodica, Manea, Paloma, Munteanu, Dragos, and Gavrilescu, Cristina Maria

Subjects
ANTICOAGULANTS, DABIGATRAN, ORAL diseases, THERAPEUTICS
Published
2015

362. GENERAL PRINCIPLES OF GERIATRIC REHABILITATION.

Author

Paraschiv, Cringuta, Esanu, Irina, Ghiuru, Rodica, and Gavrilescu, Cristina Maria

Subjects
GERIATRIC rehabilitation, QUALITY of life, ACTIVITIES of daily living
Published
2015

364. Effect of BN 50739, a new platelet activating factor antagonist, on ischaemia induced ventricular arrhythmias in isolated working rat hearts

Author

Andre Esanu, David A. Hosford, Matyas Koltai, Arpad Tosaki, and Pierre Braquet

Subjects
Male, medicine.medical_specialty, Physiology, Heart Ventricles, Coronary Disease, Myocardial Reperfusion, Ventricular tachycardia, Reperfusion therapy, Left coronary artery, Organ Culture Techniques, Physiology (medical), medicine.artery, Internal medicine, Heart rate, medicine, Animals, cardiovascular diseases, Platelet Activating Factor, Fibrillation, Dose-Response Relationship, Drug, business.industry, Gyógyszerészeti tudományok, Arrhythmias, Cardiac, Heart, Rats, Inbred Strains, Azepines, Orvostudományok, Triazoles, medicine.disease, Rats, Preload, Ventricular fibrillation, cardiovascular system, Cardiology, Ventricular pressure, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Study objective – The aim was to investigate the role of platelet activating factor (PAF) in myocardial ischaemia by using BN 50739, a new specific PAF receptor antagonist with a hetrazepine framework. Design – Isolated working rat hearts were subjected to regional ischaemia, induced by ligation of the left main coronary artery for 30 min, followed by reperfusion. BN 50739 was applied at concentrations of 10−7, 10−6, 10−5 and 5 × 10−5 M, and its effects on the incidence of ischaemia induced and reperfusion induced ventricular tachycardia and ventricular fibrillation and heart functions, such as heart rate, coronary flow, aortic flow, left ventricular developed pressure (LVDP), its first derivative (LvdP/dtmax), and left ventricular end diastolic pressure (LVEDP), were determined. Experimental material – Studies were performed on isolated working hearts of male Sprague-Dawley rats weighing 300-360 g. Hearts were perfused with BN 50739 dissolved in dimethylsulphoxide. Control hearts were perfused with the vehicle. Measurements and main results – Regional ischaemia triggered ventricular arrhythmias showing high incidence between 12 and 20 min with peak appearance at 16 min. BN 50739 induced dose dependent protection against ventricular tachycardia and fibrillation: incidences declined from their respective control values of 91% and 75% to 33% (p

Published
1991

365. Body and the East : From the 1960s to the Present

Author

Badovinac, Zdenka, Stiles, Kristine, Boubnova, Iara, Husedžinovic, Meliha, Ševcík, Jirí, Stipancic, Branka, Pejic, Bojana, Sretenovic, Dejan, Jurenaite, Raminta, Beke, László, Esanu, Octavian, Grünbein, Durs, Jakubowska, Agata, Pintilie, Ileana, Backstein, Joseph, Matuštík, Radislav, Zabel, Igor, Krpan, Jurij V., Badovinac, Zdenka, Stiles, Kristine, Boubnova, Iara, Husedžinovic, Meliha, Ševcík, Jirí, Stipancic, Branka, Pejic, Bojana, Sretenovic, Dejan, Jurenaite, Raminta, Beke, László, Esanu, Octavian, Grünbein, Durs, Jakubowska, Agata, Pintilie, Ileana, Backstein, Joseph, Matuštík, Radislav, Zabel, Igor, and Krpan, Jurij V.

Abstract

This catalogue for an exhibition focusing on body art from Eastern Europe since the 1960s features essays on eighty artists from fourteen countries. The artists are organized by country, and an essay on the historical and cultural context of each country introduces them. The book highlights artistic expression in opposition to political repression. Includes brief bio-bibliographies for each artist. Bibliography 1 p.; 78 bibl. ref.

Published
1999

366. Decision analysis in the clinical and imaging diagnosis of acute cholecystitis

Author

C, Vasilescu, G H, Jovin, I, Popescu, and C, Esanu

Subjects
Diagnosis, Differential, Acute Disease, Decision Trees, Cholecystitis, Gallbladder, Humans, Bayes Theorem, Diagnostic Errors, Radionuclide Imaging, Cholangiography, Cholecystography, Decision Support Techniques, Ultrasonography
Abstract

The importance of clinical, laboratory and imaging data in the diagnosis of acute cholecystitis (AC) was studied in 825 patients with right upper quadrant pain hospitalized in the Surgical Clinic of the Fundeni Hospital--Bucharest, between January 1, 1986 and June 30, 1988. A number of 21 parameters were analysed in each case. Of these 825 patients, 259 were considered after surgery as AC. These 259 cases were divided, after the microscopical examination of the surgically-obtained specimens, into two groups: 1) pathologically confirmed AC (137 cases) and 2) pathologically non-confirmed AC (122 cases). The importance of every parameter in establishing a histologically confirmed diagnosis of AC was determined by the diagnostic probability calculated according to Bayes'theorem. The hierarchy of the value of parameters in the diagnosis of AC was based on their capacity to distinguish between the cases histologically confirmed and those detected on surgery, but without microscopically demonstrated changes of AC. The same decision criterion was used in building the decision trees in the exploration of the cases of presumed AC. In the 825 cases with right upper quadrant pain, the main and most frequent cause was chronic calculous cholecystitis (31.8%), followed by AC pathologically confirmed (16.6%), AC non-confirmed (14.7%) and chronic acalculous cholecystitis (12.4%). The most useful parameters in distinguishing between pathologically confirmed AC and pathologically non-confirmed AC were: 1) sudden onset of pain; 2) mild resistance to abdominal palpation; 3) frank peritoneal irritation; 4) stone impacted in the gallbladder neck (ultrasonography); 5) fever; 6) palpable gallbladder; 7) lithiasis (ultrasonography); 8) gallbladder wall with double outline (ultrasonography). Ultrasonography supplied a diagnostic probability of 85% for the correct diagnosis of AC in cases without a clinical picture suggestive for AC. The decision tree analysis supported the same conclusion: only ultrasonography gives a good distinction between pathologically confirmed AC and pathologically non-confirmed AC.

Published
1990

370. CBM Collaboration

Author

Ablyazimov, T., Abuhoza, A., Adak, R., Adamczewski-Musch, J., Adamczyk, M., Aggarwal, M.M., Ahammed, Z., Ahmad, F., Ahmad, N., Ahmad, S., Akindinov, A., Akishin, P., Akishina, E., Akishina, T., Akishina, V., Al-Turany, M., Alexandrov, E., Alexandrov, I., Amar-Youcef, S., Anđelić, M., Andreeva, O., Andrei, C., Andronic, A., Anisimov, Yu., Appelshäuser, H., Arend, A., Argintaru, D., Atkin, E., Avdeev, S., Averbeck, R., Azmi, M.D., Baban, V., Bach, M., Badura, E., Baginyan, S., Balle, T., Balog, T., Bandyopadhyay, S., Banerjee, P., Baranova, N., Barczyk, T., Bartoş, D., Bashir, S., Basrak, Z., Baszczyk, M., Batenkov, O., Baublis, V., Baumann, C., Baznat, M., Becker, K.-H., Bel, T., Belogurov, S., Bendarouach, J., Berceanu, I., Bercuci, A., Berdermann, E., Berdnikov, A., Berdnikov, Y., Berendes, R., Bergmann, C., Bertini, D., Bertini, O., Beşliu, C., Bezshyyko, O., Bhaduri, P.P., Bhasin, A., Bhati, A.K., Bhattacharjee, B., Bhattacharyya, A., Bhattacharyya, T.K., Biswas, S., Blau, D., Blume, C., Bocharov, Yu., Böttger, S., Borysova, M., Breitner, T., Brüning, U., Brzychczyk, J., Bubak, A., Büsching, H., Bychkov, A., Byszuk, A., Cai, Xu, Cãlin, M., Cao, Ping, Čaplar, R., Caragheorgheopol, G., Carević, I., Cătănescu, V., Chakrabarti, A., Chatterji, S., Chattopadhyay, Sanatan, Chattopadhyay, Subhasis, Chen, Hongfang, Cheng, Jianping, Chepurnov, V., Chernenko, S., Chernogorov, A., Choi, Kyung-Eon, Ciobanu, M.I., Claus, G., Constantin, F., Covlea, V., Csanád, M., D'Ascenzo, N., Das, S., Davkov, K., Davkov, V., de Cuveland, J., Debnath, B., Dementiev, D., Deng, Zhi, Deppe, H., Deppner, I., Derenovskaya, O., Deveaux, C.A., Deveaux, M., Dey, K., Dey, M., Dillenseger, P., Dobyrn, V., Doering, D., Dorokhov, A., Drozd, A., Dubey, A.K., Dubnichka, S., Dubnichkova, A., Dürr, M., Dulinski, W., Dutka, L., Dželalija, M., Emschermann, D., Engel, H., Eremin, V., Eşanu, T., Eschke, J., Eschweiler, D., Eum, Jongsik, Fan, Huanhuan, Fateev, O., Filozova, I., Finogeev, D., Fischer, P., Flemming, H., Frankenfeld, U., Friese, V., Friske, E., Fröhlich, I., Frühauf, J., Fülöp, Á., Gajda, J., Galatyuk, T., Galkin, A., Galkin, V., Gangopadhyay, G., García Chávez, C., Gašparić, I., Gebelein, J., Ghosh, P., Ghosh, S.K., Goffe, M., Golinka-Bezshyyko, L., Golovatyuk, V., Golovnya, S., Golovtsov, V., Golubeva, M., Golubkov, D., Gómez Ramírez, A., Gorbunov, S., Gorokhov, S., Gottschalk, D., Gryboś, P., Grzeszczuk, A., Guber, F., Gudima, K., Gupta, A., Gusakov, Yu., Haldar, A., Haldar, S., Hartmann, H., Hehner, J., Heidel, K., Heine, N., Hellbär, E., Herghelegiu, A., Herrmann, N., Heß, B., Heuser, J.M., Himmi, A., Höhne, C., Holzmann, R., Huang, Guangming, Huang, Xinjie, Hutsch, J., Hutter, D., Iakovleva, E., Ierusalimov, A., Ilgenfritz, E.-M., Irfan, M., Ivanov, M., Ivanov, Valery, Ivanov, Victor, Ivanov, Vladimir, Ivashkin, A., Jaaskelainen, K., Jahan, H., Jain, V., Jakovlev, V., Janson, T., Jipa, A., Kadenko, I., Kämpfer, B., Kalcher, S., Kalinin, V., Kampert, K.-H., Kang, Tae Im, Kaptur, E., Karabowicz, R., Karavichev, O., Karavicheva, T., Karmanov, D., Karnaukhov, V., Karpechev, E., Kasiński, K., Kasprowicz, G., Kaur, M., Kazantsev, A., Kebschull, U., Kekelidze, G., Khan, M.M., Khan, S.A., Khanzadeev, A., Khasanov, F., Khvorostukhin, A., Kirakosyan, V., Kirejczyk, M., Kiryakov, A., Kiš, M., Kisel, I., Kisel, P., Kiselev, S., Kiss, A., Kiss, T., Klaus, P., Kłeczek, R., Klein-Bösing, Ch., Kleipa, V., Kmon, P., Koch, K., Kochenda, L., Koczoń, P., König, W., Kohn, M., Kolb, B.W., Kolosova, A., Komkov, B., Kopfer, J.M., Korolev, M., Korolko, I., Kotte, R., Kotynia, A., Kovalchuk, A., Kowalski, S., Koziel, M., Kozlov, G., Kravtsov, P., Krebs, E., Kreidl, C., Kresan, D., Kretschmar, G., Kretz, M., Krieger, M., Kryshen, E., Kucewicz, W., Kudin, L., Kugler, A., Kulakov, I., Kunkel, J., Kurepin, A., Kurilkin, P., Kushpil, V., Kyva, V., Ladygin, V., Lara, C., Larionov, P., Laso Garcia, A., Lavrik, E., Lazanu, I., Lebedev, A., Lebedev, S., Lebedeva, E., Lehnert, J., Lehrbach, J., Lemke, F., Li, Cheng, Li, Jin, Li, Qiyan, Li, Yuanjing, Li, Yulan, Lindenstruth, V., Linev, S., Linnik, B., Litvinenko, E., Liu, Feng, Lobanov, I., Lobanova, E., Löchner, S., Loizeau, P.-A., Lucio Martínez, J.A., Lymanets, A., Maevskaya, A., Mahajan, S., Mahapatra, D.P., Mahmoud, T., Maj, P., Majka, Z., Malakhov, A., Malankin, E., Malkevich, D., Malyatina, O., Malygina, H., Mandal, S., Manko, V., Manz, S., Marin, V., Marin Garcia, A.M., Markert, J., Masciocchi, S., Matulewicz, T., Merkin, M., Mialkovski, V., Michel, J., Miftakhov, N., Mikhailov, K., Mikhaylov, V., Milanović, B., Militsija, V., Mir, M.F., Miskowiec, D., Morhardt, T., Müller, W.F.J., Müntz, C., Murin, Yu., Najman, R., Naumann, L., Nayak, T., Nedosekin, A., Neumann, B., Niebur, W., Nikulin, V., Normanov, D., Nüssle, M., Oancea, A., Oh, Kunsu, Onishchuk, Y., Osipov, D., Ososkov, G., Ossetski, D., Otfinowski, P., Ovcharenko, E., Pal, S., Panasenko, I., Panda, N.R., Parzhitskiy, S., Pauly, C., Peng, Haiping, Peric, I., Peshekhonov, D., Peshekhonov, V., Petráček, V., Petriş, M., Petrovici, A., Petrovici, M., Petrovskiy, A., Petukhov, O., Piasecki, K., Pieper, J., Pietraszko, J., Płaneta, R., Plekhanov, E., Plotnikov, V., Plujko, V., Pluta, J., Poliakov, V., Polozov, P., Pop, A., Popov, V., Pospisil, V., Potukuchi, B.V.K.S., Pouryamout, J., Poźniak, K., Prakash, A., Prokudin, M., Pshenichnov, I., Pugach, M., Pugatch, V., Querchfeld, S., Radulescu, L., Raha, S., Raja, W., Rami, F., Raniwala, R., Raniwala, S., Raportirenko, A., Rautenberg, J., Rauza, J., Ray, R., Razin, S., Reichelt, P., Reinecke, S., Reshetin, A., Ristea, C., Ristea, O., Roether, F., Romaniuk, R., Rost, A., Rostchin, E., Rostovtseva, I., Roy, A., Rożynek, J., Ryabov, Yu., Rykalin, V., Sadovsky, A., Sadovsky, S., Sahoo, R., Sahu, P.K., Saini, J., Samanta, S., Sambyal, S.S., Samsonov, V., Sánchez Rosado, J., Sau, S., Saveliev, V., Schatral, S., Schiaua, C., Schmidt, C.J., Schmidt, H.R., Schmidt, K., Schweda, K., Scurtu, A., Seck, F., Seddiki, S., Selyuzhenkov, I., Semennikov, A., Senger, A., Senger, P., Shabunov, A., Shao, Ming, Sharma, M.K., Shumeiko, N., Shumikhin, V., Sikora, B., Simakov, A., Simon, C., Simons, C., Singaraju, R.N., Singh, A.K., Singh, B.K., Singh, C.P., Singhal, V., Siwek-Wilczyńska, K., Škoda, L., Skwira-Chalot, I., Som, I., Song, Jihye, Sorokin, I., Sosin, Z., Soyk, D., Staszel, P., Stavinskiy, A., Stephan, E., Storozhyk, D., Strikhanov, M., Strohauer, S., Stroth, J., Sturm, C., Sultanov, R., Sun, Yongjie, Svoboda, O., Szczygieł, R., Talukdar, R., Tang, Zebo, Tanha, M., Tarasiuk, J., Tarassenkova, O., Târzilă, M.-G., Tiflov, V., Tischler, T., Tlustý, P., Toia, A., Tolyhi, T., Topil'skaya, N., Trageser, C., Trivedy, P., Tsakov, I., Tsyupa, Yu., Turowiecki, A., Uhlig, F., Usenko, E., Valin, I., Vasiliev, T., Vassiliev, I., Verbitskaya, E., Verhoeven, W., Veshikov, A., Visinka, R., Viyogi, Y.P., Volkov, S., Volkov, Yu., Vorobiev, A., Voronin, A., Vovchenko, V., Vznuzdaev, E., Vznuzdaev, M., Wang, Dong, Wang, Yaping, Yi, Wang, Wendisch, C., Wessels, J.P., Wiebusch, M., Wiechula, J., Wiedemann, B., Wielanek, D., Wieloch, A., Winckler, N., Winter, M., Wiśniewski, K., Wohlfeld, D., Wolf, Gy., Sanguk, Won, Wüstenfeld, J., Xiang, Changzhou, Nu, Xu, Yi, Jun-Gyu, Yin, Zhongbao, Yoo, In-Kwon, Yue, Qian, Yuldashev, B., Yushmanov, I., Zabołotny, W., Zaitsev, Yu., Zanevsky, Yu., Zhalov, M., Zhang, Ya Peng, Zhang, Yifei, Zhou, Daicui, Zhu, Xianglei, Zinchenko, A., Zipper, W., Żoładź, M., Zrelov, P., Zryuev, V., Zumbruch, P., and Zyzak, M.

Published
2014
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371. Author Correction: Electrochemical evaluation of proton beam radiation effect on the B16 cell culture.

Author

Onea, Melania, Bacalum, Mihaela, Radulescu, Andreea Luminita, Raileanu, Mina, Craciun, Liviu, Esanu, Tiberiu Relu, and Enache, Teodor Adrian

Subjects
PROTON beams, CELL culture, OPEN access publishing, HIGHER education research, RADIATION
Abstract

Correction to: I Scientific Reports i https://doi.org/10.1038/s41598-022-06277-6, published online 10 February 2022 The Acknowledgments section in the original version of this Article was incomplete. "Financial support from the Operational Programme Competitiveness 2014-2020, Project NANO-BIOSURF-SMIS 103528 and Executive Agency for Higher Education and Research Funding (UEFISCDI) and National Research Council (CNCS) the Core Program 2019-2022 (contract 21N/2019) and the project PN-III-P4-ID-PCE-2020-1403, within PNCDI III, are gratefully acknowledged." now reads: "Financial support from the Operational Programme Competitiveness 2014-2020, Project NANO-BIOSURF-SMIS 103528 and Executive Agency for Higher Education and Research Funding (UEFISCDI) and National Research Council (CNCS) the Core Program 2019-2022 (contract 21N/2019) and the project PN-III-P4-ID-PCE-2020-1403, within PNCDI III, are gratefully acknowledged. [Extracted from the article]

Published
2022
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377. The CBM Collaboration

Author

Abuhoza, A., Adamczewski-Musch, J., Aggarwal, M.M., Ahammed, Z., Ahmad, F., Ahmad, N., Ahmad, S., Akindinov, A., Akishin, P., Akishina, E., Akishina, T., Akishina, V., Al-Turany, M., Amar-Youcef, S., Anđelić, M., Andrei, C., Andronic, A., Anisimov, Yu., Appelshäuser, H., Arend, A., Argintaru, D., Armbruster, T., Atkin, E., Avdeyev, S., Azmi, M.D., Baban, V., Bach, M., Badura, E., Baginyan, S., Balog, T., Bandyopadhyay, S., Banerjee, P., Baranova, N., Bartoş, D., Bashir, S., Basrak, Z., Baszczyk, M., Batenkov, O., Baublis, V., Baumann, C., Becker, K.-H., Bel, T., Belogurov, S., Berceanu, I., Berdermann, E., Berdnikov, A., Berdnikov, Y., Berendes, R., Bergmann, C., Bertini, D., Beşliu, C., Bezshyyko, O., Bhaduri, P.P., Bhasin, A., Bhati, A.K., Bhattacharjee, B., Bhattacharyya, A., Bhattacharyya, T.K., Biswas, S., Blau, D., Blume, C., Bocharov, Yu., Böttger, S., Borysova, M., Bozsogi, B., Breitner, T., Brüning, U., Brzychczyk, J., Bubak, A., Bychkov, A., Cai, Xu, Cãlin, M., Čaplar, R., Caragheorgheopol, G., Carević, I., Cătănescu, V., Chakrabarti, A., Chatterji, S., Chattopadhyay, Sanatan, Chattopadhyay, Subhasis, Chen, Hongfang, Cheng, Jianping, Chepurnov, V., Chernenko, S., Chernogorov, A., Ciobanu, M.I., Claus, G., Constantin, F., Covlea, V., Csanád, M., DʼAscenzo, N., Das, S., Davkov, K., Davkov, V., de Cuveland, J., Debnath, B., Deng, Zhi, Deppe, H., Deppner, I., Derenovskaya, O., Deveaux, M., Dey, K., Dey, M., Dillenseger, P., Dobyrn, V., Doering, D., Domachowski, M., Dorokhov, A., Dritsa, C.A., Dubey, A.K., Dubnichka, S., Dubnichkova, A., Dulinski, W., Dželalija, M., Emschermann, D., Engel, H., Eremin, V., Eşanu, T., Eschke, J., Fateev, O., Fischer, P., Flemming, H., Frankenfeld, U., Friese, V., Fröhlich, I., Frühauf, J., Fülöp, Á., Gajda, J., Galatyuk, T., Galkin, A., Galkin, V., Gangopadhyay, G., Ganti, M.S., García Chávez, C., Gašparić, I., Gebelein, J., Ghosh, P., Ghosh, S.K., Goffe, M., Golovatyuk, V., Golovnya, S., Golovtsov, V., Golubeva, M., Golubkov, D., Gorbunov, S., Gottschalk, D., Gryboś, P., Grzeszczuk, A., Guber, F., Gupta, A., Gusakov, Yu., Haldar, A., Haldar, S., Hartig, M., Hehner, J., Heidel, K., Heine, N., Herghelegiu, A., Herrmann, N., Heß, B., Heuser, J.M., Himmi, A., Höhne, C., Holzmann, R., Huang, Guangming, Hutsch, J., Hutter, D., Ierusalimov, A., Ilgenfritz, E.-M., Irfan, M., Ivanov, Valery, Ivanov, Victor, Ivanov, Vladimir, Ivashkin, A., Jaaskelainen, K., Jakovlev, V., Janson, T., Jipa, A., Kadenko, I., Kämpfer, B., Kalcher, S., Kalinin, V., Kampert, K.-H., Kang, Tae Im, Kaptur, E., Karabowicz, R., Karavichev, O., Karavicheva, T., Karmanov, D., Karnaukhov, V., Karpechev, E., Kasiński, K., Kaur, M., Kazantsev, A., Kebschull, U., Kekelidze, G., Khan, M.M., Khan, S.A., Khanzadeev, A., Khasanov, F., Kirakosyan, V., Kirejczyk, M., Kiš, M., Kisel, I., Kisel, P., Kiselev, S., Kiss, A., Kiss, T., Kłeczek, R., Klein-Bösing, Ch., Kleipa, V., Koch, K., Kochenda, L., Koczoń, P., Kolb, B., Komkov, B., Kopfer, J.M., Korolev, M., Korolko, I., Kotte, R., Kotynia, A., Kovalchuk, A., Kowalski, S., Koziel, M., Kozlov, G., Kravtsov, P., Kreidl, C., Kresan, D., Kretz, M., Krieger, M., Kryshen, E., Kucewicz, W., Kudin, L., Kugler, A., Kulakov, I., Kunkel, J., Kurepin, A., Kyva, V., Ladygin, V., Lara, C., Larionov, P., Laso Garcia, A., Lavrik, E., Lazanu, I., Lebedev, A., Lebedev, S., Lebedeva, E., Lehrbach, J., Lemke, F., Li, Cheng, Li, Jin, Qyian, Li, Li, Yuanjing, Li, Yulan, Lindenstruth, V., Linev, S., Litvinenko, E., Liu, Feng, Lobanov, I., Lobanova, E., Löchner, S., Loizeau, P.-A., Lymanets, A., Maevskaya, A., Mahajan, S., Mahapatra, D.P., Mahmoud, T., Maj, P., Majka, Z., Malakhov, A., Malyatina, O., Malygina, H., Manjavidze, J., Manko, V., Manz, S., Marin, V., Matulewicz, T., Merkin, M., Mialkovski, V., Miftakhov, N., Mikhailov, K., Milanovic, B., Militsija, V., Mir, F., Müller, W.F.J., Müntz, C., Murin, Yu., Naumann, L., Nayak, T., Neumann, B., Niebur, W., Nikulin, V., Nüssle, M., Oancea, A., Kunsu, Oh, Onishchuk, Y., Ososkov, G., Ossetski, D., Otfinowski, P., Ovcharenko, E., Susanta, Pal, Panasenko, I., Parzhitskiy, S., Pauly, C., Peng, Haiping, Peric, I., Peshekhonov, D., Peshekhonov, V., Petráček, V., Petriş, M., Petrovici, A., Petrovici, M., Petrovskiy, A., Petukhov, O., Piasecki, K., Pietraszko, J., Plekhanov, E., Plujko, V., Poliakov, V., Polozov, P., Pop, A., Popov, V., Pospisil, V., Potukuchi, B.V.K.S., Pouryamout, J., Prakash, A., Prokudin, M., Pshenichnov, I., Pugatch, V., Querchfeld, S., Raha, S., Raja, W., Rami, F., Raniwala, R., Raniwala, S., Raportirenko, A., Rautenberg, J., Ray, R., Razin, S., Reichelt, P., Reinecke, S., Reshetin, A., Ristea, C., Ristea, O., Rostchin, E., Rostovtseva, I., Roy, A., Rożynek, J., Ryabov, Yu., Rykalin, V., Sadovsky, A., Sadovsky, S., Sahu, P.K., Saini, J., Sambyal, S.S., Samsonov, V., Sanchez Rosado, J., Saveliev, V., Schatral, S., Schiaua, C., Schmidt, C.J., Schmidt, H.R., Schrader, C., Schweda, K., Scurtu, A., Seddiki, S., Semennikov, A., Senger, A., Senger, P., Shabunov, A., Shao, Ming, Sharma, M.K., Shumikhin, V., Sikora, B., Simakov, A., Simon, C., Simons, C., Singaraju, R.N., Singh, A.K., Singh, B.K., Singh, C.P., Singhal, V., Singla, M., Siwek-Wilczynska, K., Škoda, L., Jihye, Song, Sorokin, I., Soyk, D., Staszel, P., Stavinskiy, A., Stephan, E., Storozhyk, D., Strikhanov, M., Stroth, J., Sturm, C., Sun, Yongjie, Svoboda, O., Szczygieł, R., Talukdar, R., Tang, Zebo, Tarassenkova, O., Târzilă, M., Tiflov, V., Tischler, T., Tlustý, P., Tolyhi, T., Topilʼskaya, N., Trageser, C., Trivedy, P., Tsakov, I., Tsyupa, Yu., Uhlig, F., Usenko, E., Valin, I., Vasiliev, T., Vassiliev, I., Verbitskaya, E., Verhoeven, W., Veshikov, A., Viyogi, Y., Volkov, S., Volkov, Yu., Vorobiev, A., Voronin, A., Vznuzdaev, E., Vznuzdaev, M., Wang, Dong, Wang, Yaping, Wang, Yi, Wendisch, C., Wessels, J.P., Wiechula, J., Wiedemann, B., Winter, M., Wisniewski, K., Wohlfeld, D., Wolf, Gy., Wüstenfeld, J., Xiang, Changzhou, Nu, Xu, Yi, Jun-Gyu, Zhongbao, Yin, Yoo, In-Kwon, Yue, Qian, Yushmanov, I., Zaitsev, Yu., Zanevsky, Yu., Zhalov, M., Zhang, Ya Peng, Zhang, Yifei, Daicui, Zhou, Zhu, Xianglei, Zinchenko, A., Zipper, W., Żoładź, M., Zrelov, P., Zryuev, V., Zumbruch, P., and Zyzak, M.

Published
2013
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378. Mucocutaneous lesions associated with SARS-CoV-2 infection (Review).

Author

Toader, Mihaela Paula, Branisteanu, Daniel Constantin, Glod, Mihai, Esanu, Irina Mihaela, Branisteanu, Catalina Ioana, Capsa, Maria-Stefana, Dimitriu, Andreea, Nicolescu, Alin Codrut, Pinzariu, Alin Constantin, and Branisteanu, Daciana Elena

Subjects
COVID-19, SARS-CoV-2, COVID-19 pandemic, INFECTION, CORONAVIRUS diseases, COVID-19 testing
Abstract

The ongoing COVID-19 pandemic, declared by the World Health Organisation in March 2020, with the emergence of new, possibly more contagious and more virulent strains, remains a research subject, with the complex systemic involvement better described and understood, but also with a variety of skin and mucosal lesions described in the literature. Mucocutaneous lesions associated with SARS-CoV-2 infection are still under investigation, due to their polymorphic clinical aspect and incompletely understood pathogenic mechanism. The cutaneous inflammatory, exanthematous and purpuric rashes, erythemato-purpuric enanthems, oral ulcers, lichenoid oral lesions, conjunctivitis, conjunctival pseudomembranes, or corneal lesions have been described in patients with COVID-19. Several classifications have been proposed based on the clinical pattern, histological findings, and possible pathogenic mechanisms. The pathogenic mechanism, the diagnostic criteria, the prognostic importance of these lesions are still being debated. The diverse clinical aspects of dermatological manifestations render the diagnosis difficult. However, several clinical patterns strongly associated with COVID-19, such as chilblains, papulovesicular exanthems, and febrile rash require increased awareness and changes to the investigation protocols for these conditions, to include testing for SARS-CoV-2. In the present review, the mucocutaneous findings associated with the novel coronavirus infection, reported thus far in the literature, was provided. [ABSTRACT FROM AUTHOR]

Published
2022

387. PAF

Author

Koltai, Matyas, primary, Hosford, David, additional, Guinot, Philippe, additional, Esanu, André, additional, and Braquet, Pierre, additional

Published
1991
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391. BN 50739

Author

Koltai, M., primary, Spinnewyn, B., additional, Duverger, D., additional, Pirotzky, E., additional, Esanu, A., additional, Braquet, P., additional, and Castañer, J., additional

Published
1991
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392. Evidence for a suIfo-conjugate as active metabolite of cicletanine

Author

Ricardo P. Garay, Thierry Tarrade, Corinne Nazaret, Phillipe Berthet, Clelia Rosati, Pierre Braquet, and Andre Esanu

Subjects
Cicletanine, Physiology, Stereochemistry, business.industry, Internal Medicine, medicine, Cardiology and Cardiovascular Medicine, business, Active metabolite, medicine.drug, Conjugate
Published
1991

393. BN 50739

Author

M. Koltai, B. Spinnewyn, D. Duverger, E. Pirotzky, A. Esanu, P. Braquet, and J. Castañer

Subjects
Pharmacology, Pharmacology (medical)
Published
1991

394. Links between Infections, Lung Cancer, and the Immune System.

Author

Budisan, Liviuta, Zanoaga, Oana, Braicu, Cornelia, Pirlog, Radu, Covaliu, Bogdan, Esanu, Victor, Korban, Schuyler S., and Berindan-Neagoe, Ioana

Subjects
LUNG cancer, IMMUNE system, LUNG development, BACTERIAL diseases, VIRUS diseases
Abstract

Lung cancer is the leading disease of cancer-related deaths worldwide. Since the beginning of the 20th century, various infectious agents associated with lung cancer have been identified. The mechanisms that include systemic inflammatory pathways as effect of microbial persistence in the lung can secondarily promote the development of lung carcinogenesis. Chronic inflammation associated with lung-cancer infections is known to precede tumor development, and it has a strong effect on the response(s) to therapy. In fact, both viral and bacterial infections can activate inflammatory cells and inflammatory signaling pathways. In this review, an overview of critical findings of recent studies investigating associations between each of viral and bacterial pathogens and lung carcinoma is provided, with particular emphasis on how infectious organisms can interfere with oncogenic processes and all the way through immunity. Moreover, a discussion of the direct crosstalk between lung tumor development and inflammatory processes is also presented. [ABSTRACT FROM AUTHOR]

Published
2021
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395. Enhancing Proton Radiosensitivity of Chondrosarcoma Using Nanoparticle-Based Drug Delivery Approaches: A Comparative Study of High- and Low-Energy Protons.

Author

Tudor, Mihaela, Popescu, Roxana Cristina, Irimescu, Ionela N., Rzyanina, Ann, Tarba, Nicolae, Dinischiotu, Anca, Craciun, Liviu, Esanu, Tiberiu Relu, Vasile, Eugeniu, Hotnog, Andrei Theodor, Radu, Mihai, Mytsin, Gennady, Mihailescu, Mona, and Savu, Diana Iulia

Subjects
*LINEAR energy transfer, *IRON oxide nanoparticles, *CHEMICAL fingerprinting, *SCANNING electron microscopy, *COMPARATIVE method, *GENETIC toxicology
Abstract

To overcome chondrosarcoma's (CHS) high chemo- and radioresistance, we used polyethylene glycol-encapsulated iron oxide nanoparticles (IONPs) for the controlled delivery of the chemotherapeutic doxorubicin (IONPDOX) to amplify the cytotoxicity of proton radiation therapy. Human 2D CHS SW1353 cells were treated with protons (linear energy transfer (LET): 1.6 and 12.6 keV/µm) with and without IONPDOX. Cell survival was assayed using a clonogenic test, and genotoxicity was tested through the formation of micronuclei (MN) and γH2AX foci, respectively. Morphology together with spectral fingerprints of nuclei were measured using enhanced dark-field microscopy (EDFM) assembled with a hyperspectral imaging (HI) module and an axial scanning fluorescence module, as well as scanning electron microscopy (SEM) coupled with energy-dispersive X-Ray spectroscopy (EDX). Cell survival was also determined in 3D SW3153 spheroids following treatment with low-LET protons with/without the IONPDOX compound. IONPDOX increased radiosensitivity following proton irradiation at both LETs in correlation with DNA damage expressed as MN or γH2AX. The IONPDOX–low-LET proton combination caused a more lethal effect compared to IONPDOX–high-LET protons. CHS cell biological alterations were reflected by the modifications in the hyperspectral images and spectral profiles, emphasizing new possible spectroscopic markers of cancer therapy effects. Our findings show that the proposed treatment combination has the potential to improve the management of CHS. [ABSTRACT FROM AUTHOR]

Published
2024
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396. Stigmatising Attitudes Towards Mental Health Conditions Among Medical Students In Five South-Eastern European Countries

Author

Harhaji Sanja, Tomori Sonila, Nakov Vladimir, Chihai Jana, Radić Ivana, Mana Tedi, Stoychev Kaloyan, Esanu Andrei, and Pirlog Mihail Cristian

Subjects
stigmatisation, medical students, mental disorders, psychiatry, mental health, stigmatizacija, študenti medicine, duševne motnje, psihiatrija, duševno zdravje, Public aspects of medicine, RA1-1270
Abstract

Stigmatising attitudes towards mentally ill people are present among healthcare professionals. The aim of the study was to evaluate medical students' attitudes in five medical schools from Albania, Bulgaria, Moldova, Romania and Serbia and to determine if psychiatry clerkship improves these attitudes.

Published
2024
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397. Cicletanine.

Author

Chabrier, Pierre Etienne, Guinot, Philippe, Tarrade, Thierry, Auguet, Michel, Cabanie, Madeleine, Clostre, Francois, Etienne, Annie, Esanu, André, and Braquet, Pierre

Published
1988
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