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Latein und Griechisch in Nordrhein-Westfalen, Bd. 4 Nr. 1 (2023): Demokratiebildung

Latein und Griechisch in Nordrhein-Westfalen, Bd. 1 Nr. 1 (2020): Tag der offenen Tür

Despite its major role in the Earth’s climate regulation, the evolution of high-latitude ocean dynamics through geological time remains unclear. Around Antarctica, changes in the Southern Ocean (SO) circulation are inferred to be responsible for cooling from the late Eocene and glaciation in the early Oligocene. Here, we present a geochemical study of foraminifera from DSDP Site 277 (Campbell Plateau), to better constrain thermal and redox evolution of the high latitude southwest Pacific Ocean during this time interval. From 56 to 48 Ma, Mg/Ca- and δ18O-paleothermometers indicate high surface and bottom water temperatures (24–26°C and 12–14°C, respectively), while weak negative Ce anomalies indicate poorly oxygenated bottom waters. This is followed by a cooling of ∼4° between 48 and 42 Ma, possibly resulting from a weakening of a proto-EAC (East Australian Current) and concomitant strengthening of a proto-Ross gyre. This paleoceanographic change is associated with better ventilation at Site 277, recorded by an increasing negative Ce anomaly. Once this proto-Ross gyre was fully active, increasing biogenic sedimentation rates and decreasing Subbotina sp. δ13C values indicate enhanced productivity. This resulted in a shoaling of the oxygen penetration in the sediment pile recorded by increasing the foraminiferal U/Ca ratio. The negative Ce anomaly sharply increased two times at ∼35 and ∼31 Ma, indicating enhanced seawater ventilation synchronously with the opening of the Tasmanian and Drake Passage gateways, respectively. The Oligocene glaciation is recorded by a major increase of bottom seawater δ18O during the EOT (Eocene-Oligocene Transition) while Mg/Ca-temperatures remain rather constant. This indicates a significant ice control on the δ18O record.

Latein und Griechisch in Nordrhein-Westfalen, Bd. 3 Nr. 2 (2022): Texterschließung

Latein und Griechisch in Nordrhein-Westfalen, Bd. 3 Nr. 2 (2022): Texterschließung

Latein und Griechisch in Nordrhein-Westfalen, Bd. 3 Nr. 2 (2022): Texterschließung

Latein und Griechisch in Nordrhein-Westfalen, Bd. 3 Nr. 2 (2022): Texterschließung

High $T_c$ cuprate strange metals are noted for a DC-resistivity that scales linearly with $T$ from the onset of superconductivity to the crystal melting temperature, indicative of a Planckian dissipation life time $\tau_{\hbar}\simeq\hbar/(k_B T)$. At the same time, the optical conductivity ceases to be of the Drude form at high temperatures, suggesting a change in dynamics that surprisingly leaves the $T$-linear DC-resistivity unaffected. We use the AdS/CFT correspondence that describes strongly coupled, densely entangled states of matter to study the DC and optical conductivities of the local quantum critical Gubser-Rocha holographic strange metal in 2+1D in the presence of a lattice potential, a prime candidate to compare with experiment. We find that the DC-resistivity is linear in $T$ at low temperatures for a range of potential strengths and wavevectors, even as it transitions between different dissipative regimes. At weak lattice potential the optical conductivity evolves with temperature from a Drude form to a bad metal characterized by a mid-IR resonance without changing the DC transport, similar to that seen in cuprate strange metals. This mid-IR peak can be understood as a consequence of Umklapp hydrodynamics: i.e. hydrodynamic perturbations are Bloch modes in the presence of a lattice. At strong lattice potential an incoherent metal is realized where momentum conservation no longer plays a role in transport. In this regime the thermal diffusivity appears insensitive to the breaking of translations and can be explained by Planckian dissipation originating in universal microscopic chaos. The charge diffusivity cannot be explained this way, though the continuing linear-in-T DC resistivity saturates to an apparent universal slope, numerically equal to a Planckian rate. We conjecture that this may originate in chaos properties that differ between charged and neutral operators., Comment: 64 pages, 16 figures

Background and Objectives: Scar formation after burn trauma has a significant impact on the quality of life of burn patients. Hypertrophic scars or keloids can be very distressing to patients due to potential pain, functional limitations, or hyper- or hypopigmentation. In a previous study comparing Suprathel® and the new and cheaper dressing epicitehydro®, we were able to show that pain reduction, exudation, and time until wound-healing of partial-thickness burn wounds were similar, without any documented infections. No study exists that objectively measures and compares skin and scar quality after treatment with Suprathel® and epicitehydro® at present. Materials and Methods: In this study, the scar quality of 20 patients who had been treated with Suprathel® and epicitehydro® was objectively assessed using the Cutometer®, Mexameter®, and Tewameter®, as well as subjectively with the Patient and Observer Scar Assessment Scale, 3, 6, and 12 months after burn injury. Results: In all performed measurements, no significant differences were detected in scar formation after treatment of partial-thickness burn wounds with the two dressings. Conclusions: Both the newer and less expensive wound-dressing epicitehydro® and the well-known wound-dressing Suprathel® resulted in stable wound closure and showed good cosmetic results in the follow-up examinations.

Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with polypectomy when polyps were identified. Comparison was made with a retrospective cohort reported by the International Mismatch Repair Consortium (IMRC). This comprised confirmed and inferred path_MMR carriers who were first- or second-degree relatives of Lynch syndrome probands. Results In the PLSD, 8,153 subjects had follow-up colonoscopy surveillance for a total of 67,604 years and 578 carriers had CRC diagnosed. Average cumulative incidences of CRC in path_MLH1 carriers at 70 years of age were 52% in males and 41% in females; for path_MSH2 50% and 39%; for path_MSH6 13% and 17% and for path_PMS2 11% and 8%. In contrast, in the IMRC cohort, corresponding cumulative incidences were 40% and 27%; 34% and 23%; 16% and 8% and 7% and 6%. Comparing just the European carriers in the two series gave similar findings. Numbers in the PLSD series did not allow comparisons of carriers from other continents separately. Cumulative incidences at 25 years were < 1% in all retrospective groups. Conclusions Prospectively observed CRC incidences (PLSD) in path_MLH1 and path_MSH2 carriers undergoing colonoscopy surveillance and polypectomy were higher than in the retrospective (IMRC) series, and were not reduced in path_MSH6 carriers. These findings were the opposite to those expected. CRC point incidence before 50 years of age was reduced in path_PMS2 carriers subjected to colonoscopy, but not significantly so.

Latein und Griechisch in Nordrhein-Westfalen, Bd. 2 Nr. 1 (2021): Leistungsbewertung

Latein und Griechisch in Nordrhein-Westfalen, Bd. 2 Nr. 1 (2021): Leistungsbewertung

Lynch syndrome (LS), Lynch-like syndrome (LLS), and familial colorectal cancer type X (FCCX) are different entities of familial cancer predisposition leading to an increased risk of colorectal cancer (CRC). The aim of this prospective study was to characterize and to compare the risks for adenoma and CRC in these three risk groups. Data was taken from the registry of the German Consortium for Familial Intestinal Cancer. Patients were prospectively followed up in an intensified colonoscopic surveillance programme that included annual examinations. Cumulative risks for adenoma and CRC were calculated separately for LS, LLS, and FCCX, and then for males and females. Multivariate Cox regression was used to analyse the independent contributions of risk group, mismatch repair gene (within LS), sex, and previous adenoma. The study population comprised 1448 individuals (103 FCCX, 481 LLS and 864 LS). The risks were similar for colorectal adenomas, but different for first and metachronous CRC between the three risk groups. CRC risk was highest in LS, followed by LLS, and lowest in FCCX. Male sex and a prevalent adenoma in the index colonoscopy were associated with a higher risk for incident adenoma and CRC. In patients with LS, CRC risks were particularly higher in female MSH2 than MLH1 carriers. This study may support the development of risk-adapted surveillance policies in LS, LLS and FCCX. This article is protected by copyright. All rights reserved.

Among the available dressings for partial-thickness burn wound treatment, SUPRATHEL has shown good usability and effectiveness for wound healing and patient comfort and has been used in many burn centres in the last decade. Recently, bacterial nanocellulose (BNC) has become popular for the treatment of wounds, and many studies have demonstrated its efficacy. epicitehydro , consisting of BNC and 95% water, is a promising product and has recently been introduced in numerous burn centres. To date, no studies including direct comparisons to existing products like SUPRATHEL have been conducted. Therefore, we aimed to compare epicitehydro to SUPRATHEL in the treatment of partial-thickness burns. Twenty patients with partial-thickness burns affecting more than 0.5% of their total body surface area (TBSA) were enrolled in this prospective, unicentric, open, comparative, intra-individual clinical study. After debridement, the wounds were divided into two areas: one was treated with SUPRATHEL and the other with epicitehydro . Wound healing, infection, bleeding, exudation, dressing changes, and pain were documented. The quality of the scar tissue was assessed subjectively using the Patient and Observer Scar Scale. Wound healing in patients with a mean TBSA of 9.2% took 15 to 16 days for both treatments without dressing changes. All wounds showed minimal exudation, and patients reported decreased pain with the only significant difference between the two dressings on day 1. No infection or bleeding occurred in any of the wounds. Regarding scar evaluation, SUPRATHEL and epicitehydro did not differ significantly. Both wound dressings were easy to use, were highly flexible, created a safe healing environment, had similar effects on pain reduction, and showed good cosmetic and functional results without necessary dressing changes. Therefore, epicitehydro can be used as an alternative to SUPRATHEL for the treatment of partial-thickness burn wounds.

As part of the SARS-CoV‑2 pandemic, the district of Heinsberg developed into an infectiological epicentre for Germany in February 2020. Our hospital, which is located in the immediate vicinity, reacted very quickly in addition to adapting patient care by implementing an organizational structure for recording SARS-CoV-2-positive employees, patients and their contact persons.The infections recorded in contact tracing were analysed and, based on an exemplary outbreak, infection chains and follow-up processes were evaluated.Comprehensive data on contact types, oropharyngeal swab results for SARS-CoV‑2 and quarantine days were documented and retrospectively evaluated using a self-developed database.Of the 568 employees recorded by in-house contact tracing, 32 employees (1.2%, n = 2567) were detected as SARS-CoV‑2 positive. Of those, 50% (n = 16) tested positive due to contact tracing, 15.6% (n = 5) were recorded by routine smears and 34.4% (n = 11) were returning travellers. The variable PCR results of the control smears from these positive employees were noticeable. In 18.8% (n = 6) of the initially negative control smears, positive PCR results were found in the following control smear. The inhouse contact tracing team was able to detect infection clusters on non-COVID-19 wards at an early stage and, together with clinical hygiene and the public health department, initiated comprehensive measures to limit the spread of the virus. Infection chains could thus be interrupted.The work of the clinic's own contact tracing unit has proven to be an essential part of clinical pandemic management not least against the background of new waves of infection and is indispensable for the detection of local infection clusters.HINTERGRUND: Im Rahmen der SARS-CoV-2-Pandemie entwickelte sich der Kreis Heinsberg im Februar 2020 zu einem infektiologischen Epizentrum für Deutschland. Unser in unmittelbarer Nachbarschaft gelegenes Krankenhaus implementierte neben der Anpassung der Patientenversorgung sofort zusätzlich eine krankenhausinterne Organisationsstruktur zur Erfassung SARS-CoV-2-positiver Mitarbeiter, Patienten und deren Kontaktpersonen.Die im Contact Tracing erfassten Infektionen wurden analysiert und anhand eines beispielhaften Ausbruchs Infektionsketten und Nachverfolgungsprozesse evaluiert.Daten zu Kontakten, Abstrichergebnissen und Quarantänetagen wurden mittels einer eigenen Datenbank dokumentiert und retrospektiv ausgewertet.568 Mitarbeiter wurden vom krankenhausinternen Contact Tracing erfasst. 32 Mitarbeiter (1,2 %, n = 2567) wurden als SARS-CoV-2-positiv erfasst. 50 % (16) davon wurden im Rahmen der Kontaktpersonennachverfolgung positiv getestet, 15,6 % (5) durch Routineabstriche erfasst. 34,4 % (11) waren Reiserückkehrer. Auffällig waren variable PCR-Ergebnisse der Kontrollabstriche dieser positiven Mitarbeiter. Bei 18,8 % (6) wurden bei zunächst negativem Kontrollabstrich im folgenden Kontrollabstrich wieder positive PCR-Ergebnisse gefunden. Das eigene Contact Tracing konnte Infektionshäufungen auf Non-COVID-19-Stationen frühzeitig aufdecken und gemeinsam mit der Klinikhygiene und dem Gesundheitsamt umfassende Maßnahmen zur Begrenzung der Virusausbreitung einleiten. Infektionsketten konnten früh durchbrochen werden.Ein krankenhausinternes Contact Tracing erweist sich vor allem bei nicht auszuschließenden zukünftigen Infektionswellen als ein wesentlicher Bestandteil des klinischen Pandemiemanagements und ist essenziell zur Aufdeckung von lokalen Infektionsclustern.