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COVID-19 is an infectious disease caused by a new coronavirus first discovered in 2019. The infection has spread rapidly throughout the world and affects people of all ages. Thus, 12.7% of all SARS-CoV-2 patients are children. Purpose - to establish the clinical and paraclinical manifestations of the course of COVID-19 in children, depending on age to predict the severity of the disease’s manifestation. Materials and methods. The 60 children aged from 3 months to 17 years old with laboratory-confirmed SARS-CoV-2 were examined. All patients underwent general clinical, laboratory, and instrumental examinations and received therapy according to Ukrainian National protocol. SARS-CoV-2 infection was confirmed by real-time PCR. Results. Thus, in young children COVID-19 begins acutely (90.0%) with intoxication (75.0%), fever (65.0%), nasal congestion (25.0%), rhinorrhea (20.0%), dry cough (60.0%), increased ESR and C-reactive protein (55.0%). The course of COVID-19 in children 4-6 years is accompanied by acute onset (85.71%), fever (85.71%), pharyngitis (85.71%), lymphopenia (28.56%), and no CT signs of lesions (71.43%). In children 7-12 years old, COVID-19 causes intoxication (88.89%), fever (83.33%), pharyngitis (55.56%), dry cough (77.78%), lymphocytosis (16.67%) with accelerated ESR (38.89%) and pneumonia (38.89%). The course of COVID-19 in children was older than 13 years old characterized by fever (73.33%), pharyngitis (66.67%), dry cough (73.33%), olfactory loss (20.0%), leukopenia (20.0%), ESR acceleration (20.0%), and a decrease in prothrombin (13.33%) without pulmonary lesions (73.33%). Conclusions. These data suggest that the severity and duration of clinical and laboratory manifestations of COVID-19 depend on the child’s age. The course of COVID-19 in children of all age groups is mostly of moderate severity with a favorable prognosis ((56.67%) hospitalized children did not have any complications). Only children from 7 to 12 years old need additional attention due to the severe manifestations of intoxication (88.89%) and the risk of complications with pneumonia (38.89%). The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

The article discusses the residual effects of survivors of COVID-19, referred to as long-term covid, a short list of their manifestations, their possible causes and difficulties of recognition. Changes in the primary structure of emerging coronaviruses from the Wuhan strain to new omicron strains are analyzed. Among the features of their evolution, there is an increase in the content of arginine and lysine, especially in the S1 subunit, and a decrease in the proportion of aspartic and glutamic amino acids. The receptorbinding domain of omicrons is characterized by a tendency to decrease the content of threonine, serine and glutamine. Mutations in the S protein are characterized by asymmetry in relation to both substitutable and substitutive amino acids. Isoleucine and cysteine are not replaced. Certain trends and limitations in the mutations of their S protein and especially the unusual ratio transversion: transitions in them argue for the version of the artificial origin of the SARS-Cov-2 variants. At the level of the S protein genes, there are prohibitions regarding the use of certain codons. To assess the effectiveness of vaccines and the sensitivity of coronaviruses to them during a pandemic, it is useful to divide pandemic coronaviruses into two groups: omicrons and pre-omicrons. This division is justified by the fact that these groups differ sharply in the number of mutations and changes in the composition of immune epitopes, especially in the receptor-binding domain. The specific tendency of changes in its amino acid composition, apparently, is associated with a consistent decrease in pathogenicity in BA.1, BA.2, BA.4 and BA.5 variants. Taking into account these features makes it possible to predict the sensitivity of coronavirus strains to the vaccines used and rationally design vaccines with a wide range of specificity.

The subject of study in this article is modern technologies, tools and methods of building AI systems as a service using FPGA as a platform. The goal is to analyze modern technologies and tools used to develop FPGA-based projects for systems that implement artificial intelligence as a service and to prepare a practical AI service prototype. Task: to analyze the evolution of changes in the products of leading manufacturers of programmable logic devices and experimental and practical examples of the implementation of the paradigm of continuous reprogramming of programmable logic; analyze the dynamics of changes in the development environment of programmable logic systems for AI; analyze the essential elements of building projects for AI systems using programmable logic. According to the tasks, the following results were obtained. The area of application of hardware implementation of artificial intelligence for on-board and embedded systems including airspace industry, smart cars and medical systems is analyzed. The process of programming FPGA accelerators for AI projects is analyzed. The analysis of the capabilities of FPGA with HBM for building projects that require enough of high speed memory is performed. Description languages, frameworks, the hierarchy of tools for building of hardware accelerators for AI projects are analyzed in detail. The stages of prototyping of AI projects using new FPGA development tools and basic DPU blocks are analyzed. The parameters of the DPU blocks were analyzed. Practical steps for building such systems are offered. The practical recommendations for optimizing the neural network for FPGA implementation are given. The stages of neural network optimization are provided. The proposed steps include pruning of branches with low priority and the use of fixed point computations with custom range based on the requirements of an exact neural network. Based on these solutions, a practical case of AI service was prepared, trained and tested. Conclusions. The main contribution of this study is that, based on the proposed ideas and solutions, the next steps to create heterogeneous systems based on the combination of three elements are clear: AI as a service, FPGA accelerators as a technology for improving performance, reliability and security, and cloud or Edge resources to create FPGA infrastructure and AI as service. The development of this methodological and technological basis is the direction of further R&D.

Here, the authors discover that ligandability of BTB domains correlates with the presence of μs-ms time scale dynamics. This finding suggests that protein dynamics may be a broadly applicable tool in drug discovery to assess the ligandability of novel and challenging targets.

Endometrial cancer (EC) ranks second in the structure of oncogynecological diseases both in Ukraine and worldwide. More than 80 % of recurrences occur in the first two years after surgical treatment. Molecular biological markers are extensively studied in different oncological diseases, because they allow to understand the etiology and pathogenesis of malignant growth more deeply. Aim. To study molecular biological markers and tumor hormonal status in patients with EC and determine their practical significance. Materials and methods. Molecular biologic markers of the tumor were studied in 89 stage I–IV EC patients. To study the hormonal status of the tumor in EC patients, 119 examinations were carried out. Results. Significant correlations were found between the level of molecular biological marker (MBM) expression, hormonal status of the tumor, the presence of disease recurrence, and the age of EC patients. The novelty of the study lay in the substantiation of treatment individualization for EC patients based on the determination of the tumor molecular biological characteristics and their prognostic value. It has been proven that the expression level of the studied MBM, ER and PR receptors in EC patients differed depending on age, presence, localization and severity of disease recurrence. A group of patients with a high risk of the disease recurrence has been revealed among EC patients. For the first time, a technology has been developed for the combined treatment of patients with I–II (T1-2N0M0) stages of EC with a negative receptor status (EP–, PR–) and a high risk of the disease recurrence to assess MBM levels (VEGF, Bcl-2, Ki-67), degree of differentiation, myometrial invasion depth and tumor localization in the uterine cavity allowing to individualize the choice of adjuvant therapy regimen, thus improving the effectiveness of treatment and preventing the occurrence of locoregional relapses and distant metastases. Conclusions. For the first time, the expression levels of the studied molecular biological markers and ER and PR receptors have been shown to differ depending on age, localization, and relapse severity, which could be used to determine the risk of relapse in EC patients.

Natural focal infections with transmissible transmission caused by viruses of West Nile Fever, Batai, Inco, Sindbis, Tyagin are registered in various territories of Russia, in the form of sporadic cases, characterized by polymorphism of clinical symptoms, from inapparent forms to severe, occurring with Central nervous system damage (meningitis, meningoencephalitis), which complicates the timely diagnosis and treatment of this pathology.Purpose: to describe our own clinical observations of five cases of arbovirus fevers.Results. Arbovirus fevers (West Nile Fever, Batai, Inko, Tyaginya) in the five clinical cases we have presented occurred in two clinical forms: catarrhal with hypertension syndrome, febrile fever and intense headache, vomiting in the absence of signs of inflammation in the CSF; and with damage to the central nervous system (meningitis). Catarrhal forms of arboviral fevers must be differentiated from ARVI, influenza, mononucleosis. Arbovirus fevers occurring with Central nervous system lesions (meningitis) had a significant similarity with enteroviral meningitis, both in terms of seasonality and clinical symptoms.Conclusion. In the territories of Russia endemic for mosquito fevers, in the summer period of the year, febrile patients with cerebral symptoms and / or meningeal symptoms should be examined for a group of arbovirus fevers.

In this research, digital technologies that will potentially be useful for teachers in an inclusive educational space were considered. The combined classification of digital technologies of inclusive direction, including software and hardware in three main areas, is offered: for training and repetition; to help with learning; and to expand learning opportunities. The authors developed and theoretically substantiated a model for preparing pre-service teachers to use digital technologies in an inclusive educational space. The effectiveness of the developed model was tested through a pedagogical experiment that involved three tests based on criteria. The effectiveness of the authors’ model was confirmed by the sign test at the significance level of 0.05.

The physicochemical conditions of the siliconizing and boron–siliconizing processes of molybdenum-based alloys in a closed reaction space in an environment of chlorine and fluorine at reduced pressure were studied. Theoretical calculations of the equilibrium composition of systems with the participation of silicon, boron, molybdenum, nitrogen, oxygen, chlorine, and fluorine were carried out, which made it possible to determine the influence of process parameters (temperature, composition of the reaction medium) on the probable phase composition of the obtained coatings. Based on thermodynamic calculations, the composition and rational consumption of the initial powders and the temperature intervals of the chemical heat treatment (CHT) during the complex saturation of molybdenum-based alloys with silicon and boron were modeled. It was established that it is advisable to use chlorine as an activator, which leads to the formation of molybdenum chlorides MoCl4 and MoCl3 in the composition of the gas phase and can indicate the flow of exchange reactions between chlorides and the matrix of the processed material in the reaction space. The rational saturation temperature of alloys based on molybdenum with silicon and boron is determined—1100–1250 °C. The possibility of the existence of condensed phases MoSi2, MoB2.15, B6Si, MoB1.65, and MoB is shown.

Ensuring noise immunity is one of the main tasks of radio engineering and telecommunication. The main task of signal receiving comes down to the best recovery of useful information from a signal that is destructed during propagation and received together with interference. Currently, the interference and noise control comes to the fore. Modern elements and methods of processing, related to intelligent systems, strengthen the role of the verification and recognition of targets. This makes noise control particularly relevant. The most-important quantitative indicator that characterizes the quality of the useful signal is the signal-to-noise ratio. Therefore, determining the noise parameters is very important. In the present paper, a signal model is used in the form of an additive mixture of useful signals and Gaussian noise. It is an ordinary model of a received signal in radio engineering and communications. It is shown that the phase portrait of this signal has the shape of an ellipse at the low noise level. For the first time, an expression of the width of the ellipse line is obtained, which is determined by the noise dispersion. Currently, in electroencephalography, diagnosis is based on the Fourier transform. But, many brain diseases are not detected by this method. Therefore, the search and use of other methods of signal processing is relevant.

The article considers the concept of “transfer of innovations”, taking into account the specifics of the Russian agricultural sector and its basic structural elements. Its stages are highlighted, starting from the technology audit and ending with signing a contract and selling the technology to an interested partner. The reasons for the slow pace of transfer of innovative agricultural technologies and their impact on the effectiveness of the agricultural sector are explored. Promising technology transfer mechanisms in the agriculture are examined, considering their importance for this sector of the Russian economy. The author’s approach to systematization of the main areas for improving the transfer of innovative technologies in the agricultural sector in the country’s regions is offered and their importance to the regional economy is emphasized. The sources of the synergies occurring during the transfer of innovative technologies are identified and further promising research trends in this field are determined.

A method has been developed for predicting the service life of a screw pair nut with a large thrust thread, which is based on the energy theory of wear. Based on the results of finite element modeling using the DEFORM-3D software package, the dependence of the change in normal pressures on the contact surface of the nut with the screw along the height of the thread projection was established. Using the SMTs-2 friction machine, a series of experiments was carried out and the coefficient of friction and the energy index of wear intensity were determined for bronze of the brand BrA9Zh3L, used in the manufacture of nuts for screw mechanisms with coarse threads. The calculation of the service life of the nut of the pressure device of the rolling stand of the hot rolling mill 2000 has been performed. The limit value of the number of revolutions of the screw is established, the excess of which leads to critical wear and destruction of the threads.

The proposed methodology aims to determine and forecast the technical condition of bridge elements, which could serve as an advanced engineering tool for assessing reliability and durability. It is developed based on fundamental studies that synthesize the experience of studying the physical–mechanical and physical–chemical properties of materials in bridge structures operating under real conditions. The theoretical foundation of the methodology is a reliability model and residual lifetime prediction of bridge elements based on Markov’s theory. The developed methodology is designed for assessing the technical condition of individual bridge elements, followed by a comprehensive evaluation of the entire structure. Reliability during operation is adopted as the indicator of technical condition. This quantitative reliability indicator in the model serves as a criterion for evaluating the safety level of bridge elements; ranking of bridge elements as necessary for specific types of repair, reconstruction, or replacement; strategic planning of expenditures for repair or reconstruction under limited funding; and forecasting the remaining resource of elements. An evaluation and prediction algorithm for the technical condition of bridges is proposed for the application of the developed methodology. A mathematical experiment of the developed methodology was conducted, which confirmed the adequacy of the proposed hypothesis, i.e., the use of the reliability model and the prediction of residual lifetime of bridge elements. First, a three-step mechanism for refining the technical condition of the bridge is proposed, significantly enhancing the accuracy of the calculations. Therefore, the developed methodology holds practical value and can serve as a basis for information-analytical systems for managing the condition of bridges.

A phase field model to study dynamics of microstructure transformations and the evolution of defect structure during heat treatment of Fe-Cr-Al systems is developed. Statistical and kinetic properties of evolving microstructure and defect structure in alloys with different content of alloying elements and at different temperatures were studied. Point defects rearrangement during precipitation is discussed in details. Universality of statistical distributions over precipitate size is revealed for considered class of alloys.

Transformative technologies are enabling the construction of threedimensional (3D) maps of tissues with unprecedented spatial and molecularresolution. Over the next seven years, the NIH Common Fund Human BiomolecularAtlas Program (HuBMAP) intends to develop a widely accessible framework forcomprehensively mapping the human body at single-cell resolution by supportingtechnology development, data acquisition, and detailed spatial mapping. HuBMAPwill integrate its efforts with other funding agencies, programs, consortia,and the biomedical research community at large towards the shared vision of acomprehensive, accessible 3D molecular and cellular atlas of the human body, inhealth and various disease settings.

The article is devoted to the methodology and features of the scientific direction of decision analysis, which make it essential for the state strategy development in order to achieve the desired image of the future. The history of decision analysis is studied, the basics of the scientific direction are considered: systems analysis, decision theory, probabilistic analysis and cognitive psychology. Organizations that actively use the methodology and most popular computer programs for the practical implementation of decision analysis methods are represented. The domestic contribution to the decision analysis is shown. A promising sub-direction which allows strategy development in conditions of conflicting objectives (multicriteria decision analysis) is presented. The modern methodology of decision analysis is considered: the system of values and objectives of the organization, decision context, identification and evaluation of the mathematical model elements, graphical representation of the model using influence diagrams and decision trees, the procedure of mathematical modeling, optimal strategy determination based on the criterion of maximizing/minimizing the objective function value and the criterion of risk profile dominance and sensitivity analysis methods: one-way and two-way sensitivity analysis, probability sensitivity analysis and strategy dominance analysis. The article concludes that the scientific direction of decision analysis has a number of advantages that make it suitable for use in the field of state strategy development.

Background. Bones as an organ are one of the most common targets for tumor metastasis. Currently, the number of patients undergoing surgical treatment for metastatic bone lesions is steadily increasing. In most patients, after surgical treatment, the manifestation of clinical symptoms decreases, primarily pain syndrome, which improves their quality of life. However, it should be noted that the number of patients with bone metastases who underwent revision surgery is also increasing. This article retrospectively analyzes the factors leading to revision after surgical treatment of metastases in long bones. The aim of this study was to identify factors leading to revision after surgical treatment of patients with metastases in long bones. Methods. A retrospective medical records analysis of 247 patients who underwent surgical treatment for metastases in long bones on the basis of the P.A. Herzen Moscow Research Institute of Oncology in 20062020 was performed. Of these, 33 patients underwent revision surgery. The median age was 62 years. The localization of the primary tumor was as follows: breast cancer 10 cases, kidney cancer 13, lung cancer 3, prostate cancer 2, rectal cancer 3, liver cancer and Ewings sarcoma with bone metastases 1 case each. Results. The following factors led to revision surgery: mistakes in preoperative diagnosis (3 patients); postoperative infectious complication (6 patients); dislocation of the endoprosthesis (4 patients); continued growth of solitary metastasis after osteosynthesis (5 cases); aseptic instability after intramedullary osteosynthesis (14 patients); traumatic fracture of the endoprosthesis stem (1 patient). Conclusions. Revision after surgical treatment of metastases in long bones, in addition to postoperative complications, lead to mistakes in diagnosis and incorrect choice of surgical treatment method. To reduce the risk of revision surgical interventions, a multidisciplinary approach is needed with the development of surgical treatment tactics in consultation and the use of specialized scales of oncological prognosis.

Biochemical and mineral peculiarities of plants inhabiting desert and semi-desert areas may provide important information about the mechanism of their adaptability and reveal the prospects of their utilization. Rheum tataricum L., known for its high tolerance to drought, salinity, and nutritional deficiency, is the least studied species of wild rhubarb. Using biochemical and ICP-MS analysis, the antioxidant status and mineral composition of R. tataricum were determined. Extremely high levels of antioxidant activity (148–155 mg GAE g−1 d.w.), polyphenols (24.6–25.1 mg GAE g−1 d.w.) and carotenoids (1.94 mg-eq β-carotene g−1 d.w.) were revealed in roots, proline in leaves (71.1 ± 6.2 mg kg−1 d.w.) and malic acid in stems (3.40 ± 0.50 mg g−1 d.w.). Compared to garden rhubarb, R. tataricum demonstrated significant root–leaves translocation of Li, Se, Si, and Mo, known to participate in plant antioxidant defense. Under high levels of Ca, Na, Mg, Fe, Cr and Si in soil, R. tataricum demonstrated the ability to significantly increase the accumulation of these elements in roots, showing a hyperaccumulation ability for Sr. The first broad picture of R. tataricum biochemical and mineral characteristics in semi-desert habitat and its nutritional value indicate the prospects of R. tataricum utilization in plant breeding, medicine, and nutrition.

The paper suggests a model-based approach to assessment and choice of parameters of unmanned aerial vehicle (UAV) fleets applied as one of the main services for Smart Cities and recommendations to assure their dependability. The principles of building and modeling a UAV Fleet as a Dependable Service (UAVFaaDS) for Smart Cities are formulated. Dependability issues for UAVFaaDS including a taxonomy of UAVF failures caused by equipment faults and attacks on assets were specified. The main results cover methodology, classification of UAVFaaDS models as models of queuing systems, and a set of queueing theory-based models for assessment of UAVFaaDS performance, and availability allowing for analysis and choice of fleet parameters. The efficiency of UAVFaaDS is assessed by the probability of successful delivery of services. The proposed modeling base and algorithms provide a choice of appropriate models for analysis and synthesis of UAVFaaDS, grounding of parameters of UAV fleets considering operation modes, and maintenance policy. The application of the developed models and algorithms during the synthesis of UAVFaaDS allows choosing the appropriate parameters of the fleet and ensuring the dependability of services, as well as service of orders with a probability of 0.9–0.99 depending on the requirements. Two cases of UAVFaaDS application for delivery of medicines in normal and emergence modes, models’ development, and recommendations for their utilization are discussed.

Metastatic clear cell renal cell carcinoma has a poor prognosis. Here, the authors use single cell RNA-seq to show a distinct gene expression signature in the primary tumour of metastatic patients, and highlights immune cell receptor interactions as potential therapeutic targets.

The method of calculation of natural frequencies and forms of oscillations of a two-link mechanical system of a robot manipulator is proposed. Links of the system are considered as straight rods with a step change of cross-sectional parameters. The equations of motion of a mechanical system are based on the technical bending theory. The analysis of oscillation processes is carried out using the matrix method of initial parameters.

In Ukraine, an anti-terrorist operation, carried out on a significant territory of the country (about 20 percent) has been going on for eight years. All this time, hundreds of thousands of Ukrainians stay in stressful conditions. Changes occur in cognitive, behavioral, value-motivational, emotional and other spheres of these people personality. One of the risk groups is middle-aged people, because the key tasks for this stage of a person's life become difficult to implement. In women, the emotional component of this process is more intense than in men, which becomes an additional stress factor in this situation. There are studies on the emotional component in interpersonal relationships in these women, their tendency to affect, the consequences of receiving traumatic experience, impulsiveness, etc. However, the number of studies on the peculiarities of basic emotions manifestation, level indicators of anxiety, aggressiveness and other components of the emotional sphere remains insignificant, which would make it possible to develop appropriate psychocorrective programs. The purpose of the study was to identify the features of emotional sphere in middle-aged women who have been in the area of anti-terrorist operation (ATO) for a long time. Research methods – a technique for measuring the level of anxiety (J. Taylor), a scale of differential emotions (K. Izard), a technique for detecting the level of aggressiveness (Bassa-Darky). Mathematical and statistical processing - φ-criterion Fisher's angular transformation. The subjects were 40 middle-aged women employed with higher education. They are divided into two groups of 20: according to the criterion, they were in the area of anti-terrorist operation (ATO) for a long time and had never been in the specified territory. Conclusions: for the emotional sphere of middle-aged women who have been for a long time (at least 5 years) in the area of anti-terrorist operation (ATO), the phenomena of "level decrease of emotions of the positive spectrum" and "level increase of aggressiveness" and a high general level of anxiety are characteristic. In the anxiety-depressive spectrum of the emotional sphere, guilt becomes the dominant emotion. There is a tendency to increase more open forms of aggressiveness, but the manifestation of anger, on the contrary, is becoming more moderate.

Problem definition world globalization and the introduction of martial law in Ukraine led to a significant increase in the number of Ukrainians emigrating to China. The emigration process has its stages, at each of which the individual solves his tasks of social and psychological adaptation, which requires research. Problem analysis In the scientific literature, the emigration process is divided into three main stages (preparatory, moving and familiarization with new living conditions and adaptation to new conditions), in each of which adaptation is an important psychological component of this process. In the humanistic paradigm, the process of socio-psychological adaptation of the individual is the most developed and researched. The purpose of the study to reveal the stage-by-stage features of socio-psychological adaptation among Ukrainians emigrating to China. The research methods are the Rogers-Diamond diagnostic method of socio-psychological adaptation; questionnaires "Adaptive strategies of behavior" and "Satisfaction with life" according to N. Melnikova; questionnaire "Social well-being". Mathematical and statistical processing of the φ criterion - Fisher's angular transformation and the Mann-Whitney U-criterion. Description of the sample the sample consisted of 90 Ukrainians of early adulthood who are in a marital relationship and have a higher education. The sample was divided into 3 studied groups. Group 1 (Gr. 1) includes Ukrainians who plan to emigrate to China, which was confirmed by the documents they drew up for this purpose. Group 2 (Gr. 2) included Ukrainians who lived in China for no more than 1 year after moving. Until the third (Gr.3) - more than 1 year. Conclusions At the second stage of socio-psychological adaptation in the process of emigration, the indicators of emotional discomfort, non-acceptance of others, external conflict and maladjustment significantly increase among Ukrainians, which worsens their adaptation potential, however, at the third stage, its full recovery and return to the level of the emigration planning stage was revealed. At each stage, features of the manifestation of adaptive behavioral strategies, indicators of social well-being and life satisfaction were revealed.

The purpose of our article is to study psychological peculiarities of the introductory period of physical rehabilitation of patients with ischemic stroke. Research methods. There were used psychological and pedagogical research methods: the analysis of literature sources, the method of psychological and pedagogical observation, psychological and pedagogical experiment. The results of the research. We proved that psychological objectives of the introductory period of physical rehabilitation of patients with ischemic stroke were: 1) restoration of proper breathing; 2) the formation of the psychological basis for the implementation of motor actions; 3) learning the elements of basic motor actions: the accuracy of motor tasks, maintaining a certain posture (starting position) in the process of doing exercises; 4) learning the basics of ideomotor exercises; 5) learning methods of self-control. Conclusions. It was shown, when performing new exercises, patients had experienced psycho-emotional stress, which had led to signs of fatigue (even when performing only a few physical exercises). It was manifested in the form of inadequate response of the cardiovascular system to the proposed load, and changes into the psycho-emotional state of the patient (increased anxiety, loss of interest, decreased concentration, etc.). In the presence of only subjective sensations of the emotional nature, when there was no inadequate response of the cardiovascular system to the proposed load, we used the method of “switching”. In a case of “switching” we asked the patient a general question in order to listen to his/her answer. This technique significantly accelerated the recovery of the person’s activity. When we observed fatigue associated with reduced levels of functionality, the patient was offered rest until complete recovery of a cardiovascular system.

Production of functional food with high levels of selenium and other antioxidants is very valuable for human protection against different forms of oxidant stress. Among leafy vegetables parsley demonstrate the highest levels of antioxidants. Biochemical analysis and fluorimetric determination of selenium revealed that foliar biofortification of 4 parsley (Petroselinum crispum) cultivars and Mitsuba (Cryptotaenia japonica) with sodium selenate (25 mg L-1) resulted in the highest biofortification level in curly parsley cultivar Krasotka (102.9) which showed the highest leaf surface area, antioxidant activity (65 mg GAE g-1 d.w.) and flavonoids content (25.9 mg quercetin equivalent g-1 d.w.), and the increase by 1.4 times in carotene content and 1,5 times in total chlorophyll content. ICP-MS method of mineral composition evaluation recorded extremely high levels of B and Si in Mustuba, which increased due to Se supplementation by 1.23 and 1.46 times respectively. In a two-year experiment with control and Se-fortified, leafy parsley, cultivar Moskvichka reached high values of seed yield and viability, and seed Se content (6170 µg kg-1 d.w.). The results of the present investigation demonstrate high prospects of parsley and Mitsuba selenium biofortification for production of functional food with elevated levels of microelement and high antioxidant activity.

V. T. Markov was born on June 21, 1948 in China, the city of Dalniy, where the Soviet naval base was located (the legendary fortress of Port Arthur). When he [...]

The article discusses the properties of the pandemic strain XBB.1.5 S protein in comparison with the 1918 and 2009 pandemic strains hemagglutinin H1. The S-protein XBB.1.5 already contains more than 40 mutations realized by substituting different amino acids through single and dinucleotide substitutions, deletions and the use of predominantly transversions. The variability of H1N1 influenza virus hemagglutinin is associated with single nucleotide substitutions at a constant length. Conditional extrapolation of influenza virus hemagglutinin variability data on coronavirus S-protein sizes suggests that new pandemic strains will emerge in the next 2-3 years, avoiding the immune defense formed by vaccination against the strains preceding them. The inability to create through the adaptive immune system a long-term immunity to pandemic coronaviruses, as well as to other respiratory viruses with a short incubation cycle, puts on the agenda the need to find new vaccine designs that provide a combination of long-term adaptive and trained immunity. The problem in the search for such vaccines is associated with the regulation of the activity of the innate immune system and ensuring the stability of trained immunity.