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109,952 results on '"A. , Clay"'

351. Knowledge Graphs of the QAnon Twitter Network

Author

Adams, Clay, Bozhidarova, Malvina, Chen, James, Gao, Andrew, Liu, Zhengtong, Priniski, J Hunter, Lin, Junyuan, Sonthalia, Rishi, Bertozzi, Andrea L, and Brantingham, P Jeffrey

Subjects
Data Management and Data Science, Information and Computing Sciences
Published
2022

353. GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion positive rhabdomyosarcoma

Author

Morales, Jacqueline, Allegakoen, David V, Garcia, José A, Kwong, Kristen, Sahu, Pushpendra K, Fajardo, Drew A, Pan, Yue, Horlbeck, Max A, Weissman, Jonathan S, Gustafson, W Clay, Bivona, Trever G, and Sabnis, Amit J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Pediatric Cancer, Rare Diseases, Genetics, Cancer, Pediatric, 2.1 Biological and endogenous factors, Aetiology, Child, Humans, Mechanistic Target of Rapamycin Complex 1, Neoplasms, Forkhead Box Protein O1, Drug therapy, Oncology, Signal transduction, Biomedical and clinical sciences, Health sciences
Abstract

Oncogenic FOXO1 gene fusions drive a subset of rhabdomyosarcoma (RMS) with poor survival; to date, these cancer drivers are therapeutically intractable. To identify new therapies for this disease, we undertook an isogenic CRISPR-interference screen to define PAX3-FOXO1-specific genetic dependencies and identified genes in the GATOR2 complex. GATOR2 loss in RMS abrogated aa-induced lysosomal localization of mTORC1 and consequent downstream signaling, slowing G1-S cell cycle transition. In vivo suppression of GATOR2 impaired the growth of tumor xenografts and favored the outgrowth of cells lacking PAX3-FOXO1. Loss of a subset of GATOR2 members can be compensated by direct genetic activation of mTORC1. RAS mutations are also sufficient to decouple mTORC1 activation from GATOR2, and indeed, fusion-negative RMS harboring such mutations exhibit aa-independent mTORC1 activity. A bisteric, mTORC1-selective small molecule induced tumor regressions in fusion-positive patient-derived tumor xenografts. These findings highlight a vulnerability in FOXO1 fusion-positive RMS and provide rationale for the clinical evaluation of bisteric mTORC1 inhibitors, currently in phase I testing, to treat this disease. Isogenic genetic screens can, thus, identify potentially exploitable vulnerabilities in fusion-driven pediatric cancers that otherwise remain mostly undruggable.

Published
2022

354. Ko te mōhiotanga huna o te hunga kore kōrero i te reo Māori

Author

Hay, Jennifer, King, Jeanette, Todd, Simon, Panther, Forrest, Mattingley, Wakayo, Oh, Yoon Mi, Beckner, Clay, Needle, Jeremy, and Keegan, Peter

Subjects
Language Studies, Linguistics
Abstract

This article outlines recent experiments on the implicit knowledge of non-Māori speakers living in New Zealand. It expands on the work of Oh et al. (2020) who show that, despite not knowing the language, non-Māori speakers have impressive phonotactic and lexical knowledge, which has presumably been built through ambient exposure to the language. In this paper, we extend this work by investigating morphological and syntactic knowledge. Experiment 1 asks non-Māori speakers to morphologically segment Māori words. It shows that they have an impressive degree of ability to recognize Māori morphs, and also that their false segmentations are in the locations that are phonotactically most likely to be morpheme boundaries. Experiment 2 asks non-Māori speakers to rate the likelihood that Māori sentences are grammatical. They rate grammatical Māori sentences significantly higher than matched sentences containing the same words in the wrong order. Their error patterns reveal significant sensitivity to legal versus non-legal sentence endings. Taken together, the results reveal that ambient exposure to te reo Māori leads to extensive subconscious knowledge regarding te reo Māori, and provide a strong real-world example of implicit language learning.

Published
2022

363. Single-blind determination of methane detection limits and quantification accuracy using aircraft-based LiDAR

Author

Bell, Clay, Rutherford, Jeff, Brandt, Adam, Sherwin, Evan, Vaughn, Timothy, and Zimmerle, Daniel

Subjects
Earth Sciences, Atmospheric Sciences, Affordable and Clean Energy, Methane, Detection limits, Quantification accuracy, Controlled release testing, LiDAR
Abstract

Methane detection limits, emission rate quantification accuracy, and potential cross-species interference are assessed for Bridger Photonics’ Gas Mapping LiDAR (GML) system utilizing data collected during laboratory testing and single-blind controlled release testing. Laboratory testing identified no significant interference in the path-integrated methane measurement from the gas species tested (ethylene, ethane, propane, n-butane, i-butane, and carbon dioxide). The controlled release study, comprised of 650 individual measurement passes, represents the largest dataset collected to date to characterize GML with respect to point-source emissions. Binomial regression is utilized to create detection curves illustrating the likelihood of detecting an emission of a given size under different wind conditions and for different flight altitudes. Wind-normalized methane detection limits (90% detection rate) of 0.25 (kg/h)/(m/s) and 0.41 (kg/h)/(m/s) are observed at a flight altitude of 500 feet and 675 feet above ground level, respectively. Quantification accuracy is also assessed for emissions ranging from 0.15 to 1,400 kg/h. When emission rate estimates were generated using wind from high-resolution rapid refresh (HRRR) model (the primary wind source that Bridger uses for their commercial operations), linear regression indicates bias of 8.1% (R2 = 0.89). For 95% of controlled releases above Bridger’s stated production-sector detection sensitivity (3 kg/h with 90% probability of detection), the accuracy of individual emission rate estimates produced using HRRR wind ranged from −64.1% to +87.0%. Across all controlled releases, 38.1% of estimates had error within ±20%, and 87.3% of measurements were within a factor of two (−50% to +100% error). At low wind speed (less than 2 m/s) and low emission rates (less than 3 kg/h), emission estimates are biased high, however when removed do not impact the regression significantly. The aggregate quantification error including all detected emission events was +8.2% using the HRRR wind source. The resulting detection curves and quantification accuracy illustrate important implications that must be considered when using measurements from GML or other remote emission measurement techniques to inform or validate inventory models or to audit reported emission levels from oil and gas systems.

Published
2022

364. Supervised learning and the finite-temperature string method for computing committor functions and reaction rates

Author

Hasyim, Muhammad R, Batton, Clay H, and Mandadapu, Kranthi K

Subjects
Engineering, Chemical Sciences, Physical Sciences, Temperature, Molecular Dynamics Simulation, Algorithms, Supervised Machine Learning, Chemical Physics, Chemical sciences, Physical sciences
Abstract

A central object in the computational studies of rare events is the committor function. Though costly to compute, the committor function encodes complete mechanistic information of the processes involving rare events, including reaction rates and transition-state ensembles. Under the framework of transition path theory, Rotskoff et al. [Proceedings of the 2nd Mathematical and Scientific Machine Learning Conference, Proceedings of Machine Learning Research (PLMR, 2022), Vol. 145, pp. 757-780] proposes an algorithm where a feedback loop couples a neural network that models the committor function with importance sampling, mainly umbrella sampling, which collects data needed for adaptive training. In this work, we show additional modifications are needed to improve the accuracy of the algorithm. The first modification adds elements of supervised learning, which allows the neural network to improve its prediction by fitting to sample-mean estimates of committor values obtained from short molecular dynamics trajectories. The second modification replaces the committor-based umbrella sampling with the finite-temperature string (FTS) method, which enables homogeneous sampling in regions where transition pathways are located. We test our modifications on low-dimensional systems with non-convex potential energy where reference solutions can be found via analytical or finite element methods, and show how combining supervised learning and the FTS method yields accurate computation of committor functions and reaction rates. We also provide an error analysis for algorithms that use the FTS method, using which reaction rates can be accurately estimated during training with a small number of samples. The methods are then applied to a molecular system in which no reference solution is known, where accurate computations of committor functions and reaction rates can still be obtained.

Published
2022

365. Manipulation of the Global Regulator mcrA Upregulates Secondary Metabolite Production in Aspergillus wentii Using CRISPR-Cas9 with In Vitro Assembled Ribonucleoproteins

Author

Yuan, Bo, Keller, Nancy P, Oakley, Berl R, Stajich, Jason E, and Wang, Clay CC

Subjects
Genetics, Emerging Infectious Diseases, Emodin, Polyketide Synthases, CRISPR-Cas Systems, Ribonucleoproteins, Aspergillus, Multigene Family, Glucose, Chemical Sciences, Biological Sciences, Organic Chemistry
Abstract

Genome sequencing of filamentous fungi has demonstrated that most secondary metabolite biosynthetic gene clusters (BGCs) are silent under standard laboratory conditions. In this work, we have established an in vitro CRISPR-Cas9 system in Aspergillus wentii. To activate otherwise silent BGCs, we deleted the negative transcriptional regulator mcrA. Deletion of mcrA (mcrAΔ) resulted in differential production of 17 SMs in total when the strain was cultivated on potato dextrose media (PDA). Nine out of fifteen of these SMs were fully characterized, including emodin (1), physcion (2), sulochrin (3), physcion bianthrone (4), 14-O-demethylsulochrin (5), (trans/cis)-emodin bianthrone (6 and 7), and (trans/cis)-emodin physcion bianthrone (8 and 9). These compounds were all found to be produced by the same polyketide synthase (PKS) BGC. We then performed a secondary knockout targeting this PKS cluster in the mcrAΔ background. The metabolite profile of the dual-knockout strain revealed new metabolites that were not previously detected in the mcrAΔ parent strain. Two additional SMs were purified from the dual-knockout strain and were characterized as aspergillus acid B (16) and a structurally related but previously unidentified compound (17). For the first time, this work presents a facile genetic system capable of targeted gene editing in A. wentii. This work also illustrates the utility of performing a dual knockout to eliminate major metabolic products, enabling additional SM discovery.

Published
2022

367. Eftilagimod Alpha (a Soluble LAG-3 Protein) Combined With Pembrolizumab in Second-Line Metastatic NSCLC Refractory to Anti–Programmed Cell Death Protein 1/Programmed Death-Ligand 1-Based Therapy: Final Results from a Phase 2 Study

Author

Krebs, Matthew G., Forster, Martin, Majem, Margarita, Peguero, Julio, Iams, Wade, Clay, Tim, Roxburgh, Patricia, Doger, Bernard, Bajaj, Pawan, Barba, Andres, Perera, Suvini, Mueller, Christian, and Triebel, Frédéric

Published
2024
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373. Dominantly acting variants in ATP6V1C1 and ATP6V1B2 cause a multisystem phenotypic spectrum by altering lysosomal and/or autophagosome function

Author

Carpentieri, Giovanna, Cecchetti, Serena, Bocchinfuso, Gianfranco, Radio, Francesca Clementina, Leoni, Chiara, Onesimo, Roberta, Calligari, Paolo, Pietrantoni, Agostina, Ciolfi, Andrea, Ferilli, Marco, Calderan, Cristina, Cappuccio, Gerarda, Martinelli, Simone, Messina, Elena, Caputo, Viviana, Hüffmeier, Ulrike, Mignot, Cyril, Auvin, Stéphane, Capri, Yline, Lourenco, Charles Marques, Russell, Bianca E., Neustad, Ahna, Brunetti Pierri, Nicola, Keren, Boris, Reis, André, Cohen, Julie S., Heidlebaugh, Alexis, Smith, Clay, Thiel, Christian T., Salviati, Leonardo, Zampino, Giuseppe, Campeau, Philippe M., Stella, Lorenzo, Tartaglia, Marco, and Flex, Elisabetta

Published
2024
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376. Product Innovation Through Political and Non-political Influence Tactics

Author

Atuahene-Gima, Kwaku, Blankson, Charles, Elliot, Esi A., and Clay, Emily

Subjects
Product development -- Surveys, Decision-making -- Surveys, Time to market, Business, Human resources and labor relations
Abstract

There is little research that analyzes how managers use political and nonpolitical influence tactics to affect the product innovation strategic decision-making process (PISD). A well-appreciated power influence tactics in product innovation team is bound to contribute greatly to the success of new products. This study aims to contribute to the literature and surveys 122 carefully screened marketing and R&D executives on power antecedents of non-political (recommendation, information exchange, and assertiveness) and political (upward appeal and coalition formation) influence tactics in PISD. The study also tests the explanatory power of the underlying systemic power theory of Astley and Zajac (1991) and the related theory of Boehe (2007). The study finds that power is best reflected not only in its acquisition in terms of resources (expertise and information control) but also on its loss (power imbalance), its neutrality or balance (functional integration), and its gain or loss through the formalization of roles and responsibilities. This research suggests that theories of managerial influence tactics in PISD account for more varied, heterogeneous, and even conflicting realities. Keywords: product innovation, political and non-political influence tactics, decision-making process, marketing strategy, Marketing and strategy scholars who are interested in product innovation have long recognized that influence tactics are a collective managerial endeavor involving open, straightforward, rational discussions (non-political tactics) as well [...]

Published
2023

377. -Tocopherol reduces VLDL secretion through modulation of intracellular ER-to-Golgi transport of VLDL

Author

Clay, Ryan, Siddiqi, Shaila, and Siddiqi, Shadab A.

Subjects
Alpha tocopherol -- Usage -- Health aspects, Endoplasmic reticulum -- Health aspects, Blood lipoproteins -- Health aspects, Golgi apparatus -- Health aspects, Proteolipids -- Health aspects, Lipoproteins -- Health aspects, Biological sciences
Abstract

Avoiding hepatic steatosis is crucial for preventing liver dysfunction, and one mechanism by which this is accomplished is through synchronization of the rate of very low density lipoprotein (VLDL) synthesis with its secretion. Endoplasmic reticulum (ER)-to-Golgi transport of nascent VLDL is the rate-limiting step in its secretion and is mediated by the VLDL transport vesicle (VTV). Recent in vivo studies have indicated that [alpha]-tocopherol ([alpha]-T) supplementation can reverse steatosis in nonalcoholic fatty liver disease, but its effects on hepatic lipoprotein metabolism are poorly understood. Here, we investigated the impact of [alpha]-T on hepatic VLDL synthesis, secretion, and intracellular ER-to-Golgi VLDL trafficking using an in vitro model. Pulse-chase assays using [[sup.3]H]-oleic acid and 100 [micro]mol/L [alpha]-T demonstrated a disruption of early VLDL synthesis, resulting in enhanced apolipoprotein B-100 expression, decreased expression in markers for VTV budding, ER-to-Golgi VLDL transport, and reduced VLDL secretion. Additionally, an in vitro VTV budding assay indicated a significant decrease in VTV production and VTV- Golgi fusion. Confocal imaging of lipid droplet (LD) localization revealed a decrease in overall LD retention, diminished presence of ER-associated LDs, and an increase in Golgi-level LD retention. We conclude that [alpha]-T disrupts ER-to-Golgi VLDL transport by modulating the expression of specific proteins and thus reduces VLDL secretion. Key words: very low density lipoprotein (VLDL), VLDL transport vesicle (VTV), triacylglycerol, VLDL secretion, a- tocopherol, ER-to-Golgi trafficking, Introduction The liver relies on the synthesis and secretion of the very low density lipoprotein (VLDL) for the distribution of lipids to peripheral tissues (Tiwari and Siddiqi 2012). This process [...]

Published
2023
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378. DECONSTRUCTING THE SOFTWARE FACTORY: A Practical Application of Interorganizational Network Analysis

Author

Ryan, Zachary O., Reith, Mark G., and Koschnick, Clay M.

Subjects
Network analysis (Planning) -- Military aspects -- Research -- Methods, Military and naval science
Abstract

Program managers (PMs) have various assessment and tracking tools at their disposal designed to provide actionable insights into the cost, schedule, and performance of acquisition programs. Existing tools such as [...]

Published
2023
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383. Adapting a health facility HIV stigma-reduction participatory training intervention to address drug use stigma in HIV care and treatment clinics in Dar es Salaam, Tanzania

Author

Linda B. Mlunde, Khalida Saalim, Jessie K. Mbwambo, Pfiriael Kiwia, Elizabeth Fitch, Willbrord Manyama, Isack Rugemalila, Sue Clay, Barrot H. Lambdin, Rachel D. Stelmach, Carla Bann, and Laura Nyblade

Subjects
Tanzania, Drug abuse, Substance use, Social stigma, Stereotyping, Health facilities, Public aspects of medicine, RA1-1270
Abstract

Abstract Background HIV prevalence among people who use drugs (PWUD) in Tanzania is 4–7 times higher than in the general population, underscoring an urgent need to increase HIV testing and treatment among PWUD. Drug use stigma within HIV clinics is a barrier to HIV treatment for PWUD, yet few interventions to address HIV-clinic drug use stigma exist. Guided by the ADAPT-ITT model, we adapted the participatory training curriculum of the evidence-based Health Policy Plus Total Facility Approach to HIV stigma reduction, to address drug use stigma in HIV care and treatment clinics (CTCs). Methods The first step in the training curriculum adaptation process was formative research. We conducted 32 in-depth interviews in Dar es Salaam, Tanzania: 18 (11 men and 7 women) with PWUD living with HIV, and 14 with a mix of clinical [7] and non-clinical [7] CTC staff (5 men and 9 women). Data were analyzed through rapid qualitative analysis to inform initial curriculum adaptation. This initial draft curriculum was then further adapted and refined through multiple iterative steps of review, feedback and revision including a 2-day stakeholder workshop and external expert review. Results Four CTC drug use stigma drivers emerged as key to address in the curriculum adaptation: (1) Lack of awareness of the manifestations and consequences of drug use stigma in CTCs (e.g., name calling, ignoring PWUD and denial of care); (2) Negative stereotypes (e.g., all PWUD are thieves, dangerous); (3) Fear of providing services to PWUD, and; (4) Lack of knowledge about drug use as a medical condition and absence of skills to care for PWUD. Five, 2.5-hour participatory training sessions were developed with topics focused on creating awareness of stigma and its consequences, understanding and addressing stereotypes and fears of interacting with PWUD; understanding drug use, addiction, and co-occurring conditions; deepening understanding of drug use stigma and creating empathy, including a panel session with people who had used drugs; and working to create actionable change. Conclusion Understanding context specific drivers and manifestations of drug use stigma from the perspective of PWUD and health workers allowed for ready adaptation of an existing evidence-based HIV-stigma reduction intervention to address drug use stigma in HIV care and treatment clinics. Future steps include a pilot test of the adapted intervention.

Published
2024
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384. Strategies to improve care for older adults who present to the emergency department: a systematic review

Author

Luke Testa, Lieke Richardson, Colleen Cheek, Theresa Hensel, Elizabeth Austin, Mariam Safi, Natália Ransolin, Ann Carrigan, Janet Long, Karen Hutchinson, Magali Goirand, Mia Bierbaum, Felicity Bleckly, Peter Hibbert, Kate Churruca, and Robyn Clay-Williams

Subjects
Complex system, Urgent healthcare, Quality, Patient safety, Value-based care, Indicators, Public aspects of medicine, RA1-1270
Abstract

Abstract Background The aim of this systematic review was to examine the relationship between strategies to improve care delivery for older adults in ED and evaluation measures of patient outcomes, patient experience, staff experience, and system performance. Methods A systematic review of English language studies published since inception to December 2022, available from CINAHL, Embase, Medline, and Scopus was conducted. Studies were reviewed by pairs of independent reviewers and included if they met the following criteria: participant mean age of ≥ 65 years; ED setting or directly influenced provision of care in the ED; reported on improvement interventions and strategies; reported patient outcomes, patient experience, staff experience, or system performance. The methodological quality of the studies was assessed by pairs of independent reviewers using The Joanna Briggs Institute critical appraisal tools. Data were synthesised using a hermeneutic approach. Results Seventy-six studies were included in the review, incorporating strategies for comprehensive assessment and multi-faceted care (n = 32), targeted care such as management of falls risk, functional decline, or pain management (n = 27), medication safety (n = 5), and trauma care (n = 12). We found a misalignment between comprehensive care delivered in ED for older adults and ED performance measures oriented to rapid assessment and referral. Eight (10.4%) studies reported patient experience and five (6.5%) reported staff experience. Conclusion It is crucial that future strategies to improve care delivery in ED align the needs of older adults with the purpose of the ED system to ensure sustainable improvement effort and critical functioning of the ED as an interdependent component of the health system. Staff and patient input at the design stage may advance prioritisation of higher-impact interventions aligned with the pace of change and illuminate experience measures. More consistent reporting of interventions would inform important contextual factors and allow for replication.

Published
2024
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385. Physical properties of odorants affect behavior of trained detection dogs during close-quarters searches

Author

Daniel Mejia, Lydia Burnett, Nicholas Hebdon, Peter Stevens, Alexis Shiber, Clay Cranston, Lauryn DeGreeff, and Lindsay D. Waldrop

Subjects
Medicine, Science
Abstract

Abstract Trained detection dogs have a unique ability to find the sources of target odors in complex fluid environments. How dogs derive information about the source of an odor from an odor plume comprised of odorants with different physical properties, such as diffusivity, is currently unknown. Two volatile chemicals associated with explosive detection, ammonia (NH3, derived from ammonium nitrate-based explosives) and 2-ethyl-1-hexanol (2E1H, associated with composition C4 plastic explosives) were used to ascertain the effects of the physical properties of odorants on the search behavior and motion of trained dogs. NH3 has a diffusivity 3.6 times that of 2E1H. Fourteen civilian detection dogs were recruited to train on each target odorant using controlled odor mimic permeation systems as training aids over 6 weeks and then tested in a controlled-environment search trial where behavior, motion, and search success were analyzed. Our results indicate the target-odorant influences search motion and time spent in the stages of searching, with dogs spending more time in larger areas while localizing NH3. This aligns with the greater diffusivity of NH3 driving diffusion-dominated odor transport when dogs are close to the odor source in contrast to the advection-driven transport of 2E1H at the same distances.

Published
2024
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386. Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson’s disease

Author

Md Fahim Anjum, Clay Smyth, Rafael Zuzuárregui, Derk Jan Dijk, Philip A. Starr, Timothy Denison, and Simon Little

Subjects
Science
Abstract

Abstract Sleep disturbance is a prevalent and disabling comorbidity in Parkinson’s disease (PD). We performed multi-night (n = 57) at-home intracranial recordings from electrocorticography and subcortical electrodes using sensing-enabled Deep Brain Stimulation (DBS), paired with portable polysomnography in four PD participants and one with cervical dystonia (clinical trial: NCT03582891). Cortico-basal activity in delta increased and in beta decreased during NREM (N2 + N3) versus wakefulness in PD. DBS caused further elevation in cortical delta and decrease in alpha and low-beta compared to DBS OFF state. Our primary outcome demonstrated an inverse interaction between subcortical beta and cortical slow-wave during NREM. Our secondary outcome revealed subcortical beta increases prior to spontaneous awakenings in PD. We classified NREM vs. wakefulness with high accuracy in both traditional (30 s: 92.6 ± 1.7%) and rapid (5 s: 88.3 ± 2.1%) data epochs of intracranial signals. Our findings elucidate sleep neurophysiology and impacts of DBS on sleep in PD informing adaptive DBS for sleep dysfunction.

Published
2024
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387. Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

Author

Anna Worthmann, Julius Ridder, Sharlaine Y. L. Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O’Farrell, Alexander W. Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Marceline M. Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay F. Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, and Christian Schlein

Subjects
Science
Abstract

Abstract Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health benefits, whereas a high production of endogenous fatty acids – a process called de novo lipogenesis (DNL) - is closely linked to metabolic diseases. Determinants of PUFA incorporation into complex lipids are insufficiently understood and may influence the onset and progression of metabolic diseases. Here we show that fatty acid synthase (FASN), the key enzyme of DNL, critically determines the use of dietary PUFA in mice and humans. Moreover, the combination of FASN inhibition and PUFA-supplementation decreases liver triacylglycerols (TAG) in mice fed with high-fat diet. Mechanistically, FASN inhibition causes higher PUFA uptake via the lysophosphatidylcholine transporter MFSD2A, and a diacylglycerol O-acyltransferase 2 (DGAT2)-dependent incorporation of PUFA into TAG. Overall, the outcome of PUFA supplementation may depend on the degree of endogenous DNL and combining PUFA supplementation and FASN inhibition might be a promising approach to target metabolic disease.

Published
2024
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388. Advancing the Landscape of Multimessenger Science in the Next Decade

Author

Engel, Kristi, Lewis, Tiffany, Muzio, Marco Stein, Venters, Tonia M., Ahlers, Markus, Albert, Andrea, Allen, Alice, Solares, Hugo Alberto Ayala, Anandagoda, Samalka, Andersen, Thomas, Antier, Sarah, Alvarez-Castillo, David, Bar, Olaf, Beznosko, Dmitri, Bibrzyck, Łukasz, Brazier, Adam, Brisbois, Chad, Brose, Robert, Brown, Duncan A., Bulla, Mattia, Burgess, J. Michael, Burns, Eric, Chirenti, Cecilia, Ciprini, Stefano, Clay, Roger, Coughlin, Michael W., Cummings, Austin, D'Elia, Valerio, Dai, Shi, Dietrich, Tim, Di Lalla, Niccolò, Dingus, Brenda, Durocher, Mora, Eser, Johannes, Filipović, Miroslav D., Fleischhack, Henrike, Foucart, Francois, Frontczak, Michał, Fryer, Christopher L., Gamble, Ronald S., Gasparrini, Dario, Giardino, Marco, Goodman, Jordan, Harding, J. Patrick, Hare, Jeremy, Holley-Bockelmann, Kelly, Homola, Piotr, Hughes, Kaeli A., Humensky, Brian, Inoue, Yoshiyuki, Jaffe, Tess, Kargaltsev, Oleg, Kierans, Carolyn, Kneller, James P., Leto, Cristina, Lucarelli, Fabrizio, Martínez-Huerta, Humberto, Maselli, Alessandro, Meli, Athina, Meyers, Patrick, Mueller, Guido, Nasipak, Zachary, Negro, Michela, Niedźwiecki, Michał, Noble, Scott C., Omodei, Nicola, Oslowski, Stefan, Perri, Matteo, Piekarczyk, Marcin, Pittori, Carlotta, Polenta, Gianluca, Prechelt, Remy L., Principe, Giacomo, Racusin, Judith, Rzecki, Krzysztof, Sambruna, Rita M., Schlieder, Joshua E., Shoemaker, David, Smale, Alan, Sośnicki, Tomasz, Stein, Robert, Stuglik, Sławomir, Teuben, Peter, Thorpe, James Ira, Verbiest, Joris P., Verrecchia, Franceso, Vitale, Salvatore, Wadiasingh, Zorawar, Wibig, Tadeusz, Willox, Elijah, Wilson-Hodge, Colleen A., Wood, Joshua, Yang, Hui, and Zhang, Haocheng

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract

The last decade has brought about a profound transformation in multimessenger science. Ten years ago, facilities had been built or were under construction that would eventually discover the nature of objects in our universe could be detected through multiple messengers. Nonetheless, multimessenger science was hardly more than a dream. The rewards for our foresight were finally realized through IceCube's discovery of the diffuse astrophysical neutrino flux, the first observation of gravitational waves by LIGO, and the first joint detections in gravitational waves and photons and in neutrinos and photons. Today we live in the dawn of the multimessenger era. The successes of the multimessenger campaigns of the last decade have pushed multimessenger science to the forefront of priority science areas in both the particle physics and the astrophysics communities. Multimessenger science provides new methods of testing fundamental theories about the nature of matter and energy, particularly in conditions that are not reproducible on Earth. This white paper will present the science and facilities that will provide opportunities for the particle physics community renew its commitment and maintain its leadership in multimessenger science., Comment: 174 pages, 12 figures. Contribution to Snowmass 2021. Solicited white paper from CF07. Comments and endorsers welcome. Still accepting contributions (contact editors)

Published
2022

389. Limits to gauge coupling in the dark sector set by the non-observation of instanton-induced decay of Super-Heavy Dark Matter in the Pierre Auger Observatory data

Author

The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Albury, J. M., Allekotte, I., Cheminant, K. Almeida, Almela, A., Alvarez-Muñiz, J., Batista, R. Alves, Yebra, J. Ammerman, Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Ferreira, P. R. Araújo, Arnone, E., Velázquez, J. C. Arteaga, Asorey, H., Assis, P., Avila, G., Avocone, E., Badescu, A. M., Bakalova, A., Balaceanu, A., Barbato, F., Bellido, J. A., Berat, C., Bertaina, M. E., Bhatta, G., Biermann, P. L., Binet, V., Bismark, K., Bister, T., Biteau, J., Blazek, J., Bleve, C., Blümer, J., Boháčová, M., Boncioli, D., Bonifazi, C., Arbeletche, L. Bonneau, Borodai, N., Botti, A. M., Brack, J., Bretz, T., Orchera, P. G. Brichetto, Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Büsken, M., Caballero-Mora, K. S., Caccianiga, L., Canfora, F., Caracas, I., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Cerda, M., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Condorelli, A., Consolati, G., Contreras, F., Convenga, F., Santos, D. Correia dos, Covault, C. E., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jesús, J., de Jong, S. J., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., Franco, D. de Oliveira, de Palma, F., de Souza, V., De Vito, E., Del Popolo, A., del Río, M., Deligny, O., Deval, L., di Matteo, A., Dobre, M., Dobrigkeit, C., D'Olivo, J. C., Mendes, L. M. Domingues, Anjos, R. C. dos, Dova, M. T., Ebr, J., Engel, R., Epicoco, I., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipčič, A., Fitoussi, T., Fodran, T., Fujii, T., Fuster, A., Galea, C., Galelli, C., García, B., Vegas, A. L. Garcia, Gemmeke, H., Gesualdi, F., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Glombitza, J., Gobbi, F., Gollan, F., Golup, G., Berisso, M. Gómez, Vitale, P. F. Gómez, Gongora, J. P., González, J. M., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Hahn, S., Hamal, P., Hampel, M. R., Hansen, P., Harari, D., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Hill, G. C., Hojvat, C., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Insolia, A., Isar, P. G., Janecek, P., Johnsen, J. A., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Khakurdikar, A., Covilakam, V. V. Kizakke, Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, F., Kunka, N., Lago, B. L., Langner, N., de Oliveira, M. A. Leigui, Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Presti, D. Lo, Lopes, L., López, R., Lu, L., Luce, Q., Lundquist, J. P., Payeras, A. Machado, Mancarella, G., Mandat, D., Manning, B. C., Manshanden, J., Mantsch, P., Marafico, S., Mariani, F. M., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinelli, S., Bravo, O. Martínez, Mastrodicasa, M., Mathes, H. J., Matthews, J., Matthiae, G., Mayotte, E., Mayotte, S., Mazur, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Michal, S., Micheletti, M. I., Miramonti, L., Mollerach, S., Montanet, F., Morejon, L., Morello, C., Mostafá, M., Müller, A. L., Muller, M. A., Mulrey, K., Mussa, R., Muzio, M., Namasaka, W. M., Nasr-Esfahani, A., Nellen, L., Nicora, G., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Norwood, I., Nosek, D., Novotny, V., Nožka, L., Nucita, A, Núñez, L. A., Oliveira, C., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pawlowsky, J., Pech, M., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Martins, E. E. Pereira, Armand, J. Perez, Bertolli, C. Pérez, Perrone, L., Petrera, S., Petrucci, C., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Pont, B., Pothast, M., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Rizi, V., de Carvalho, W. Rodrigues, Rojo, J. Rodriguez, Roncoroni, M. J., Rossoni, S., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saftoiu, A., Saharan, M., Salamida, F., Salazar, H., Salina, G., Gomez, J. D. Sanabria, Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Savina, P., Schäfer, C. M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schlüter, F., Schmidt, D., Scholten, O., Schoorlemmer, H., Schovánek, P., Schröder, F. G., Schulte, J., Schulz, T., Sciutto, S. J., Scornavacche, M., Segreto, A., Sehgal, S., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Smau, R., Šmída, R., Sommers, P., Soriano, J. F., Squartini, R., Stadelmaier, M., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Streich, A., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Szadkowski, Z., Tapia, A., Taricco, C., Timmermans, C., Tkachenko, O., Tobiska, P., Peixoto, C. J. Todero, Tomé, B., Torrès, Z., Travaini, A., Travnicek, P., Trimarelli, C., Tueros, M., Ulrich, R., Unger, M., Vaclavek, L., Vacula, M., Galicia, J. F. Valdés, Valore, L., Varela, E., Vásquez-Ramírez, A., Veberič, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., Vink, J., Vorobiov, S., Wahlberg, H., Watanabe, C., Watson, A. A., Weindl, A., Wiencke, L., Wilczyński, H., Wittkowski, D., Wundheiler, B., Yushkov, A., Zapparrata, O., Zas, E., Zavrtanik, D., Zavrtanik, M., Zehrer, L., and Aloisio, R.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract

Instantons, which are non-perturbative solutions to Yang-Mills equations, provide a signal for the occurrence of quantum tunneling between distinct classes of vacua. They can give rise to decays of particles otherwise forbidden. Using data collected at the Pierre Auger Observatory, we search for signatures of such instanton-induced processes that would be suggestive of super-heavy particles decaying in the Galactic halo. These particles could have been produced during the post-inflationary epoch and match the relic abundance of dark matter inferred today. The non-observation of the signatures searched for allows us to derive a bound on the reduced coupling constant of gauge interactions in the dark sector: $\alpha_X \lesssim 0.09$, for $10^{9} \lesssim M_X/{\rm GeV} < 10^{19}$. Conversely, we obtain that, for instance, a reduced coupling constant $\alpha_X = 0.09$ excludes masses $M_X \gtrsim 3\times 10^{13}~$GeV. In the context of dark matter production from gravitational interactions alone, we illustrate how these bounds are complementary to those obtained on the Hubble rate at the end of inflation from the non-observation of tensor modes in the cosmological microwave background., Comment: 9 pages, 3 figures, accepted for publication in Phys. Rev. Lett

Published
2022
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390. Thinking about GPT-3 In-Context Learning for Biomedical IE? Think Again

Author

Gutiérrez, Bernal Jiménez, McNeal, Nikolas, Washington, Clay, Chen, You, Li, Lang, Sun, Huan, and Su, Yu

Subjects
Computer Science - Computation and Language, Computer Science - Information Retrieval
Abstract

The strong few-shot in-context learning capability of large pre-trained language models (PLMs) such as GPT-3 is highly appealing for application domains such as biomedicine, which feature high and diverse demands of language technologies but also high data annotation costs. In this paper, we present the first systematic and comprehensive study to compare the few-shot performance of GPT-3 in-context learning with fine-tuning smaller (i.e., BERT-sized) PLMs on two highly representative biomedical information extraction tasks, named entity recognition and relation extraction. We follow the true few-shot setting to avoid overestimating models' few-shot performance by model selection over a large validation set. We also optimize GPT-3's performance with known techniques such as contextual calibration and dynamic in-context example retrieval. However, our results show that GPT-3 still significantly underperforms compared to simply fine-tuning a smaller PLM. In addition, GPT-3 in-context learning also yields smaller gains in accuracy when more training data becomes available. Our in-depth analyses further reveal issues of the in-context learning setting that may be detrimental to information extraction tasks in general. Given the high cost of experimenting with GPT-3, we hope our study provides guidance for biomedical researchers and practitioners towards more promising directions such as fine-tuning small PLMs., Comment: EMNLP-Findings 2022

Published
2022

391. A low-threshold ultrahigh-energy neutrino search with the Askaryan Radio Array

Author

Allison, P., Archambault, S., Beatty, J. J., Besson, D. Z., Bishop, A., Chen, C. C., Chen, C. H., Chen, P., Chen, Y. C., Clark, B. A., Clay, W., Connolly, A., Cremonesi, L., Dasgupta, P., Davies, J., de Kockere, S., de Vries, K. D., Deaconu, C., DuVernois, M. A., Flaherty, J., Friedman, E., Gaior, R., Hanson, J., Harty, N., Hendricks, B., Hoffman, K. D., Hong, E., Hsu, S. Y., Hu, L., Huang, J. J., Huang, M. -H., Hughes, K., Ishihara, A., Karle, A., Kelley, J. L., Kim, K. -C., Kim, M. -C., Kravchenko, I., Krebs, R., Ku, Y., Kuo, C. Y., Kurusu, K., Landsman, H., Latif, U. A., Li, C. -J., Liu, T. -C., Lu, M. -Y., Madison, B., Madison, K., Mase, K., Meures, T., Nam, J., Nichol, R. J., Nir, G., Novikov, A., Nozdrina, A., Oberla, E., Osborn, J., Pan, Y., Pfendner, C., Punsuebsay, N., Roth, J., Seckel, D., Seikh, M. F. H., Shiao, Y. -S., Shultz, A., Smith, D., Toscano, S., Torres, J., Touart, J., van Eijndhoven, N., Varner, G. S., Vieregg, A., Wang, M. -Z., Wang, S. -H., Wang, Y. H., Wissel, S. A., Xie, C., Yoshida, S., and Young, R.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

In the pursuit of the measurement of the still-elusive ultrahigh-energy (UHE) neutrino flux at energies of order EeV, detectors using the in-ice Askaryan radio technique have increasingly targeted lower trigger thresholds. This has led to improved trigger-level sensitivity to UHE neutrinos. Working with data collected by the Askaryan Radio Array (ARA), we search for neutrino candidates at the lowest threshold achieved to date, leading to improved analysis-level sensitivities. A neutrino search on a data set with 208.7~days of livetime from the reduced-threshold fifth ARA station is performed, achieving a 68\% analysis efficiency over all energies on a simulated mixed-composition neutrino flux with an expected background of $0.10_{-0.04}^{+0.06}$ events passing the analysis. We observe one event passing our analysis and proceed to set a neutrino flux limit using a Feldman-Cousins construction. We show that the improved trigger-level sensitivity can be carried through an analysis, motivating the Phased Array triggering technique for use in future radio-detection experiments. We also include a projection using all available data from this detector. Finally, we find that future analyses will benefit from studies of events near the surface to fully understand the background expected for a large-scale detector., Comment: 15 pages, 8 figures

Published
2022
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392. Generalized Symmetry Breaking Scales and Weak Gravity Conjectures

Author

Cordova, Clay, Ohmori, Kantaro, and Rudelius, Tom

Subjects
High Energy Physics - Theory, High Energy Physics - Phenomenology
Abstract

We explore the notion of approximate global symmetries in quantum field theory and quantum gravity. We show that a variety of conjectures about quantum gravity, including the weak gravity conjecture, the distance conjecture, and the magnetic and axion versions of the weak gravity conjecture can be motivated by the assumption that generalized global symmetries should be strongly broken within the context of low-energy effective field theory, i.e. at a characteristic scale less than the Planck scale where quantum gravity effects become important. For example, the assumption that the electric one-form symmetry of Maxwell theory should be strongly broken below the Planck scale implies the weak gravity conjecture. Similarly, the violation of generalized non-invertible symmetries is closely tied to analogs of this conjecture for non-abelian gauge theory. This reasoning enables us to unify these conjectures with the absence of global symmetries in quantum gravity., Comment: 44 pages, 1 figure

Published
2022
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393. Effects of Charge Exchange on the Evaporative Wind of HD 209458b

Author

Debrecht, Alex, Carroll-Nellenback, Jonathan, Frank, Adam, Blackman, Eric G., Fossati, Luca, Murray-Clay, Ruth, and McCann, John

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

The role of charge exchange in shaping exoplanet photoevaporation remains a topic of contention. Exchange of electrons between stellar wind protons from the exoplanet's host star and neutral hydrogen from the planet's wind has been proposed as a mechanism to create "energetic neutral atoms" (ENAs), which could explain the high absorption line velocities observed in systems where mass loss is occurring. In this paper we present results from 3D hydrodynamic simulations of the mass loss of a planet similar to HD 209458b. We self-consistently launch a planetary wind by calculating the ionization and heating resulting from incident high-energy radiation, inject a stellar wind into the simulation, and allow electron exchange between the stellar and planetary winds. We predict the potential production of ENAs by the wind-wind interaction analytically, then present the results of our simulations, which confirm the analytic limits. Within the limits of our hydrodynamic simulation, we find that charge exchange with the stellar wind properties examined here is unable to explain the absorption observed at high Doppler velocities., Comment: arXiv admin note: text overlap with arXiv:1906.00075

Published
2022
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394. Search for Spatial Correlations of Neutrinos with Ultra-High-Energy Cosmic Rays

Author

The ANTARES collaboration, Albert, A., Alves, S., André, M., Anghinolfi, M., Ardid, M., Ardid, S., Aubert, J. -J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bendahman, M., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Caiffi, B., Calvo, D., Capone, A., Caramete, L., Carr, J., Carretero, V., Celli, S., Chabab, M., Chau, T. N., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coleiro, A., Coniglione, R., Coyle, P., Creusot, A., Díaz, A. F., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., van Eeden, T., van Eijk, D., Khayati, N. El, Enzenhöfer, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gatelet, Y., Gay, P., Glotin, H., Gozzini, R., Ruiz, R. Gracia, Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Huang, F., Illuminati, G., James, C. W., Jisse-Jung, B., de Jong, M., de Jong, P., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Breton, R. Le, LeStum, S., Lefèvre, D., Leonora, E., Levi, G., Lopez-Coto, D., Loucatos, S., Maderer, L., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Martino, B., Melis, K., Migliozzi, P., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Fearraigh, B. Ó, Păun, A., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Poirè, C., Popa, V., Pradier, T., Randazzo, N., Real, D., Reck, S., Riccobene, G., Romanov, A., Sánchez-Losa, A., Greus, F. Salesa, Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schnabel, J., Schumann, J., Schüssler, F., Seneca, J., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Tingay, S. J., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zavatarelli, S., Zegarelli, A., Zornoza, J. D., Zúñiga, J., collaboration, The IceCube, Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alameddine, J. M., Alispach, C., Alves Jr., A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Boddenberg, M., Bontempo, F., Borowka, J., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bradascio, F., Braun, J., Brinson, B., Bron, S., Brostean-Kaiser, J., Browne, S., Burgman, A., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, K., Clark, B. A., Clark, K., Classen, L., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hokanson-Fasig, B., Hoshina, K., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Li, Y., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Mariscal, C. J. Lozano, Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Martinez-Soler, I., Maruyama, R., Mase, K., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peters, L., Peterson, J., Philippen, S., Pieper, S., Pittermann, M., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Rack-Helleis, J., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reichherzer, P., Reimann, R., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schindler, S., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. 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Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

For several decades, the origin of ultra-high-energy cosmic rays (UHECRs) has been an unsolved question of high-energy astrophysics. One approach for solving this puzzle is to correlate UHECRs with high-energy neutrinos, since neutrinos are a direct probe of hadronic interactions of cosmic rays and are not deflected by magnetic fields. In this paper, we present three different approaches for correlating the arrival directions of neutrinos with the arrival directions of UHECRs. The neutrino data is provided by the IceCube Neutrino Observatory and ANTARES, while the UHECR data with energies above $\sim$50 EeV is provided by the Pierre Auger Observatory and the Telescope Array. All experiments provide increased statistics and improved reconstructions with respect to our previous results reported in 2015. The first analysis uses a high-statistics neutrino sample optimized for point-source searches to search for excesses of neutrinos clustering in the vicinity of UHECR directions. The second analysis searches for an excess of UHECRs in the direction of the highest-energy neutrinos. The third analysis searches for an excess of pairs of UHECRs and highest-energy neutrinos on different angular scales. None of the analyses has found a significant excess, and previously reported over-fluctuations are reduced in significance. Based on these results, we further constrain the neutrino flux spatially correlated with UHECRs., Comment: 39 pages, 7 figures, 4 tables; updated source files including xml authorlist

Published
2022
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395. Hyperspectral nanoscale mapping of hybrid perovskite photophysics at the single grain level

Author

Taylor, Ethan J., Iyer, Vasudevan, Dhami, Bibek S., Klein, Clay, Lawrie, Benjamin J., and Appavoo, Kannatassen

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

Hybrid organic-inorganic perovskites have drawn significant interest for applications in optoelectronics over the last few years. Despite rapid progress in understanding the photophysics of perovskite, there remains a need for improved understanding of the effect of microstructure on perovskite photophysical processes. Here, we combine unsupervised machine learning and cathodoluminescence microscopy of a prototypical hybrid perovskite film to decode photophysical processes that are otherwise lost with conventional Gaussian image processing. Hyperspectral maps are decoded with non-negative matrix factorization, revealing components relating to primary band-edge emission, photon recycling, and defect emission. A blind-spectral non-negative matrix factorization procedure provides additional understanding of changes in an intermediate perovskite phase under electron beam exposure and illustrates how traditional Gaussian techniques may hide relevant emission features that are critical to the development of environmentally robust perovskite devices, Comment: 9 pages, 4 figures

Published
2022

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