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Objective To investigate the effect of boldine on differentiation and resorption function of osteoclasts induced from mouse monocyte RAW264.7 cells in the presence of receptor activator of NF-κB Ligand (RANKL). Methods The mouse monocyte RAW264.7 cells were cultured in the presence of receptor activator of RANKL and with different concentration of boldine (1, 10, 20, 40, 80 μmol/L). On the 4 day, cells were stained by tartrate-resistant acid phosphatase (TRAP) and measured the TRAP activity to compare the number and activity of osteoclasts. CCK-8 method was used identify if boldine had toxicity on osteoclasts. The expression levels of receptor activator of NF-κB (RANK), nuclear factor of activated T cells c1 (NFATc1) and cfos were detected by Real-time PCR. On the 9 day, the bone slices were stained by toluidine blue and quantified the resorption area by Leica Qwin system. Results Compared with control group, the number of osteoclasts was decreased with the increasing of boldine concentration. The groups of 20 μmol/L, 40 μmol/L and 80 μmol/L boldine had significant differences (P < 0.05, P <0.01), TRAP activity were also obviously decreased and showed no toxicity with the increasing concentration. Compared with control group, the resorption areas were significantly reduced when boldine concentration was increased. Meanwhile, The groups of 20 μmol/L, 40 μmol/L and 80 μmol/L boldine had significant differences (P < 0.05). The expression levels of RANK、NFATc1 and c-fos were down-regulated with the increasing of boldine concentration, and the groups of 20 μmol/L, 40 μmol/L and 80 μmol/L boldine had significant differences (P < 0.05). Conclusion Boldine could suppress the differentiation and resorption function of osteoclasts induced from RAW264.7 cells in the presence of RANKL. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Beijing Normal University is the property of Beijing Normal University, Institute of History and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Liquid Crystal & Displays is the property of Chinese Journal of Liquid Crystal & Displays and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Telecommunication Engineering is the property of Telecommunication Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Collaborative filtering algorithms are one of the most successful techniques which is widely used in the field of recommendation system. However, with the rapid growth in the number of users and the lack of corresponding rating data, the problem of data sparsity in recommender systems is becoming more and more obvious, which affects recommendation quality and efficiency seriously. To solve the sparse data problem in traditional collaborative filtering algorithms, we propose a method based on gray correlation degree, combination of tag overlap factors and user ratings, which is used for the standardi­zation of the data processing of the user rating matrix, thus obtaining the user correlation degree and the association degree matrix. Clustering based on gray association degree on the correlation matrix of users can reduce computational complexity. Tag overlap factors are also introduced to improve the accuracy of the similarity between users in traditional collaborative filtering algorithms. Experimental results show that the proposed algorithm can greatly improve the prediction accuracy. [ABSTRACT FROM AUTHOR]

We present an approach to realize multi-objective and mulidisciplinary design optimization (MDO) of satelitte payload. We first analyze the key techniques in multi-objective and multidisciplinary design optimization of satelitte payload system design，and estabHsh multidisciplinary analysis models including antennas，transponders，data transmission，reliabiilty，costs and quailies. Then multi-objective genedc algorithm is adopted to opdmize the reliablilty and cost of the satelilte payload system and the Pareto opdmal set is obtained. Collaborative optimization which is one of the best feasible multidisciplinary design optimization approaches is integrated with the genedc algorlthm to carry out the reliability optimization of single objecdve design. Results show that relationship among different disciplines are well considered during the multi-objective and mulidiscipiinary design optimization. Designers can choose sadsfactory optimization results from the Pareto set according to thek own speciHc requrrements， design efticiency is therefore signiticantly improved. Collaborative optimization can help reaiize discipiine autonomy and paraUel design，improve design 乂舶丄办 and reduce design cyde. [ABSTRACT FROM AUTHOR]

Copyright of Telecommunication Engineering is the property of Telecommunication Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Mechanical & Electrical Engineering is the property of Mechanical & Electrical Engineering Magazine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To research the relationship between bone mineral density （BMD） and ultraviolet radiation intensity and sunshine time．Methods 12 published domestic articles about lumbar BMD （L1 - L4 and L2 - L4） measured by dual energy X-ray absorptiometry （DXA） from the same company， were retrieved and compared with 8 774 cases of lumbar spine BMD in Kunming area．The BMD of the above 13 areas were turned into standardized BMD （sBMD）．The annual average intensity of ultraviolet radiation and average sunshine time were found from the Chinese Academy of Sciences Ecosystem Research Network，so as to analyze the relationship between lumbar BMD and ultraviolet radiation intensity and sunshine time．Results The ultraviolet radiation intensity of men and women in all ages of the 13 region was not related to lumbar spine BMD．The sunshine time of men and women in all ages of the 13 region was not related to lumbar lumbar BMD．Conclusion The ultraviolet radiation intensity and sunshine time of the 13 region make no different influence on lumbar BMD． [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Beijing Normal University is the property of Beijing Normal University, Institute of History and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective] Exploring the erosion problem caused by grassland degradation in Gannan Prefecture can help understand the local soil and water losses, which is conducive to the construction of ecological security barrier on the Qinghai-Tibet Plateau. Methods] This study revealed the temporal and spatial changes of soil erosion in Gannan Prefecture in 2000, 2010 and 2019 based on the RIJSI'E model, and analyzed the erosion factors of Gannan Prefecture through geographical detector. Results] The overall degree of erosion in Gannan Prefecture is relatively light, mainly with slight erosion and mild erosion. The areas with strong, extremely strong and severe erosion in Gannan Prefecture are relatively small, but the areas and intensities of these types of erosion show the increasing trend with time. The spatial difference of soil erosion in Gannan Prefecture is obvious, and the soil erosion intensity in the western region is lower than that in the eastern region. The distributions of moderate, strong, very strong, and severe erosion areas are similar, showing a relatively obvious aggregation state. Zhuoni County, Diebu County and Zhouqu County show higher erosion risk than other counties. The erosion grade of 87.14% of Gan nan Prefecture did not change from 2000 to 2()19, and the transferred areas were mainly mild erosion and mild erosion areas. The areas with increased erosion levels have a higher proportion of area than areas with decreased erosion levels, which mainly distribute in Maqu County, Luqu County. Xiahe County. Zhuoni County and Diebu County. Land use and topographic undulation are the main factors affecting ecological vulnerability in Garman Prefecture. The project of returning farmland to forest (grass), agricultural and animal husbandry activities, the advancement of urbanization, and the complex topography of Gan nan Prefecture all have the greater impacts on erosion. There is enhancement when land use acting with population density, slope, elevation, ave rage annual rainfall and vegetation coverage. Conclusion] The overall erosion in Gan nan Prefecture is light, but the local erosion is strong and shows an increasing trend with time. Land use change and topographic factors have the great impacts on the erosion. Tn the future, more attention should be paid to land use change and grassland degradation, do a good job of protection and restoration should be strengthened, and the erosion deterioration risk in ecological risk areas with complex topography should be be concerned in Gan nan Prefecture. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the development of promoting the discipline construction and the improvement of new personnel training model, it is a hot topic for every Chinese traditional academy to build a sharing platform for large equipment, and to cultivate innovative medical research talents. This article hereby discusses the problems of large equipment sharing platform construction and development, and provides the feasible countermeasures for the problem through the vigorously developing large-scale construction equipment sharing platform in Anhui University of Chinese Medicine. The target of this paper is to exchange and learn the experiments of cultivating innovative medical research talents with domestic colleagues, and benefits to build the large equipment sharing platform, and to train students' practical ability and innovative ability. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The preparation methods of methyltin were reviewed. Combined with the research status of methyltin compounds at home and abroad, the application of methyltin in chemical synthesis, surface metal-organic chemistry, tin film preparation, heat stabilizer, and other fields was introduced. Some limitations of methyltin compounds were pointed out, and the future development of methyltin compounds was prospected. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to improve the attitude control accuracy and anti-disturbance performance of the quad-rotor UAV,the disturbance observer and the extended state observer are combined, and a sliding mode anti-disturbance control approach based on dual observers is proposed.First, the disturbance with part of the known information is described by the exogenous system model and estimated by the disturbance observer; then the extended state observer is used for the estimation of the complex nonlinear differentiable disturbance; then a sliding mode control law is designed to compensate for the disturbance estimated by the dual observers to achieve attitude control; finally, the stability of the system is proved by the Lyapunov theory.The simulation results show that this method has higher tracking accuracy and better anti-disturbance ability than traditional PID control. [ABSTRACT FROM AUTHOR]

Objective To investigate the binding site residues which are crucial for hydroxybenzonitrile inhibitors binding to Cdc25B phosphatase. Methods Molecular dynamics simulation was used to analyze the interactions of Cdc25B with hydroxybenzonitrile inhibitors A8H and 3M8. The hydrogen bond interaction analysis and interaction energy analysis were then used to determine the residues which were crucial for hydroxybenzonitrile inhibitors binding. Results Hydrogen bond probabilities of A8H with Y382, D397, K399, R485, R488 and R492 were 0, 2.00%, 0.40%, 0.60%, 0 and 0, respectively. Hydrogen bond probabilities of 3M8 with Y382, D397, K399, R485, R488 and R492 were 11.38%, 12.97%, 0.80%, 4.19%, 94.41% and 97.21%, respectively. D397, L398, C484, R485, R488, M505 formed strong interactions with A8H (interaction energies were -2.40 kcal/mol, -2.50 kcal/mol, -2.30 kcal/mol,-3.20 kcal/mol, -4.00 kcal/mol and -1.80 kcal/mol, respectively).Y382, D397, L398, C484, R485, R488, R492 and M505 formed strong interactions with 3M8 (interaction energies were -1.90 kcal/mol, -5.30 kcal/mol,-3.40 kcal/mol, -1.00 kcal/mol, -5.10 kcal/mol, -19.40 kcal/mol, -21.60 kcal/mol and -1.50 kcal/mol, respectively).Conclusion Y382, D397, L398, C484, R485, R488, R492 and M505 are crucial for hydroxybenzonitrile inhibitors binding to Cdc25B phosphatase. [ABSTRACT FROM AUTHOR]

The aging of our society is becoming more and more serious, and the number of middle-aged and elderly people suffering from diabetes is increasing year by year, which seriously reduces the quality of life of patients and increases the economic burden. Diabetic Kidney Disease is a serious chronic complication of diabetes, which can cause end-stage renal disease Microangiopathy is recognized as a key factor in the development of diabetic nephropathy. Recent studies at home and abroad have found that osteoporosis is also inextricably linked with microvascular disease. Clinical research have also found that diabetic nephropathy is often complicated with osteoporosis. Therefore, exploring the internal relationship between DKD and DOP from microangiopathy is helpful to clarify the molecular mechanism between them and provide new ideas for the prevention and treatment of DOP. [ABSTRACT FROM AUTHOR]

Objective To observe the effect of bone marrow mesenchymal stem cells on knee osteoarthritis rats and to explore the possible mechanisms. Methods Forty SD rats were randomly divided into normal control group（Control, saline 0.3 mL, once a week for 4 times）, knee osteoarthritis group（KOA, saline 0.3 mL, once a week for 4 times）, bone marrow mesenchymal stem cells group（BMSCs, 0.3 mL, once a week for 4 times）, 10 rats in each group, and the remaining 10 rats were used for the isolation of bone marrow MSCs. After 4 weeks, the joint index（AI） scores of rats were performed; the pathological changes of cartilage tissue were observed by HE staining; immunohistochemistry was performed to detect the expression of Col II, IL-6, MMP-3 and MMP-13 in cartilage tissues; the content of IL-6, TNF-α, MMP-3 and MMP-13 in serum was detected by ELISA method; and the expression of Col II, Col I, TNF-α, IL-6, MMP-13, KDM6 A, SOX9 and Aggrecan mRNA in cartilage tissue was detected by qRT-PCR; Western blot to detect KDM6 A, SOX9, Aggrecan protein expression in cartilage tissue. Results Compared with the control group, AI score, serum IL-6, TNF-α, MMP-3, MMP-13 content, and cartilage tissue IL-6, MMP-3, MMP-13 expression were significantly higher in the KOA group rats（P<0.05）; Col II, KDM6 A, Aggrecan, SOX9 mRNA and protein expression significantly decreased（P<0.05）. Compared with the KOA group, the BMSCs group significantly decreased AI score, significantly decreased serum IL-6, TNF-α, MMP-3, MMP-13 levels, and IL-6 mRNA expression in cartilage tissue（P<0.05）, and significantly increased KDM6 A, Aggrecan mRNA and protein expression in cartilage tissue（P<0.05）. Conclusion Bone marrow mesenchymal stem cells significantly improved the pathological damage of knee osteoarthritis and may exert therapeutic effects on knee osteoarthritis rats by regulating the KDM6 A/SOX9 signaling pathway. [ABSTRACT FROM AUTHOR]

This study aimed to study the effects of adding Stems Leaves of Angelica sinensis (ASL) pow‐ der to the diet on the growth performance, slaughtering performance, serum biochemistry and antioxidant capacity of broilers. 432 broilers were randomly divided into 6 groups according to the test requirements, each group was set up with 6 replicates, each replicate of 12 chickens, fed with a diet containing ASL of 0 (group 1), 1% (group 2), 1.5% (group 3), 2% (group 4), 2.5% (group 5), 3% (group 6), respectively, the feeding test time was 42 days. The results showed that: compared with group 1, groups 3, 4, 5, and 6 significantly increased the average feed intake and average body weight gain of broilers in the later stage (22-42 days) and throughout the experimental period (1-42 days) (P<0.05); the addition of ASL in the diet significantly increased the slaughter rate of broilers (P<0.05). Compared with group 1, groups 4 and 6 significantly increased the semi clean bore rate, full clean bore rate, chest muscle rate, and leg muscle rate of broilers (P<0.05), and significantly reduced the abdominal fat rate of broilers (P<0.05); 4, 5 and 6 groups significantly reduced blood lipid level and blood sugar content (P<0.05), significantly increased serum glutathione peroxidase activity in broilers (P<0.05), and the total antioxidant capacity of serum in 6 groups was the highest. In summary, the addition of angelica stem and leaf powder to the diet improved the production performance, slaughtering performance, serum biochemical and antioxidant capacity of broilers, and the recommended addition amount is 3%. [ABSTRACT FROM AUTHOR]

This article proposes the new method of intrinsic connection, which is combining the theory of corporate governance, information economics and media interaction intermediary effect. It's important to analyze news reports that influence on shareholders for insufficient analysis of corporate governance during many listed companies transition from the "by" media attention to the strategic "tilt" media in the recent years. We analyze the economic pressure of the tendency report on the factors such as earnings per share, net assets yield and book value, and reveal the real motivation of "media association" of listed companies, using the method of single variable multi-factor coupling and the related data of China's A-share listed company's financial and media. The research shows that:1) The high-intensity news reporting tendency contributes to the mediating effect of media information, thus improving the interests of shareholders and their relationship with listed companies; 2) The effect of media incentive is more obvious in positive media report tendency samples; 3) The high degree of marketization of the listed companies strengthens the relationship between them. When the variable of macro-environmental administrative penalty is controlled, the empirical results are still significant. This paper deepens the cognition of the media's corporate governance effect and associated motivation, and helps to realize the value of listed companies and improve their relationship with major stakeholders. [ABSTRACT FROM AUTHOR]

Objective To explore the mechanism of Zuogui Pill, a traditional Chinese medicine for tonifying the kidney, in treating ovariectomized osteoporosis in rats based on the Hedgehog signaling pathway. Methods Female SD rats were randomized into 3 groups; the blank control group, the sham operation group, and the model group. The ovaries of the model group rats were removed. In the sham operation group, only a small amount of fat tissue around the ovary was removed. After 12 weeks, the model group was randomly divided into 3 groups; the OVX group, the positive control group, the Zuogui Pill group. The positive control group was perfused with estradiol valerate suspension, the Zuogui Pill group was perfused with Zuogui Pill decoction, and the other groups were perfused with equal volume pure water. After 13 weeks, the rats were anesthetized and killed, their tibia and femur were taken. The Bone Mineral Density (BMD) of each group was detected by micro CT; The expression of the key factors of the Hedgehog signaling pathway, OPG and RANKL in bone marrow stromal cells of tibia was detected by immunohistochemistry (IHC). Results BMD in the sham operation group was higher than that in OVX group, the positive control group and the Zuogui pill group, and BMD in OVX group was lower than that in the positive control group and the Zuogui pill group . The expression levels of Ihh, Ptch, Smo, GLi1 and the ratio of RANKL/OPG in the OVX group were higher than that in the sham operation group; The protein expression levels of Ihh, Ptch, Smo, GLi1 and the ratio of RANKL/OPG in the positive control group and the Zuogui pill group were lower than those in the OVX group, but still higher than those in the sham operation group. Conclusion Zuogui Pill can inhibit the abnormal activity of Hedgehog signaling pathway caused by ovariectomy, and significantly reduce the expression level of key factors Ihh, Ptch, Smo and GLi1; Further, it can reduce the ratio of RANKL/OPG, inhibit the activity of osteoclasts (OC) and prevent bone loss. [ABSTRACT FROM AUTHOR]

It is the key and difficult point in the research of launch safety to accurately simulate the gas generation law after the fracture of propellant in the chamber. The discrete element method was adopted to establish the discrete element mechanics model of propellant. Through the presupposition discrete element ball model which representing the positive hexagonal prism geometric model, the equilateral triangle combustion model was established, and the combustion function was derived. The newly established combustion function and the traditional shape function were used to simulate and compare the gas generation law of the closed bomb respectively. The simulation object was normal propellant and fractured propellant with the same fracture degree. The results show that the combustion function could precisely calculate the change law of surface increase and combustion increase caused by the fracture of propellant. The research results solve the problem of lack of calculation method of gas generation law after random fracture of propellant before breech blow, which can be applied to the research of launch safety of propellant charge. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of different culture medium on the differentiation of RAW264. 7 cells into osteoclasts, in order to optimize the culture conditions of osteoclasts differentiation. Methods The experiment was divided into three groups; high glucose DMEM differentiation medium group (DMEM group), high glucose DMEM/α-MEM differentiation medium group (DMEM/α-MEM group), α-MEM differentiation medium group (α-MEM group ). Tartrate-resistant acid phosphatase (TRAP) staining was used to observe the formation of mature osteoclasts in each group. Toluidine blue staining was used to quantitatively analyze the area of bone lacuna to observe the function of osteoclasts. Real time PCR was used to detect the expression of NFATc-1, c-Fos and TRAF-6 mRNA. Results Typical TRAP+ osteoclasts were observed in all groups. Compared with DMEM group, the number of TRAP+ osteoclasts in DMEM/α-MEM group and α-MEM group was significantly increased (P < 0. 01). However, the morphology of every group are slightly different. Compared with DMEM group, the mRNA expressions of NFATc-1, c-Fos and TRAF-6 in α-MEM group were significantly increased (P<0. 01, P< 0.05); Compared with the DMEM group, the mRNA expression of NFATc-1 in DMEM/α-ME/M group was significantly increased (P < 0.01), and the mRNA expression of c-Fos and TRAF-6 had a tendency to increase, but there was no statistical difference, there was no significant different between α-MEM group and DMEM/α-MEM group. Conclusion High glucose DMEM differentiation medium, high glucose DMEM/α-MEM differentiation medium and α-MEM differentiation medium can induce RAW264. 7 cells to differentiate into osteoclasts, but from the number, morphology and function of osteoclasts, α-MEM medium is more suitable for osteoclast differentiation. [ABSTRACT FROM AUTHOR]

目的 观察桑苏饮加味方口服在肺切除术后的临床应用效果. 方法 选择肺切除术后患者128例, 随机 分为观察组和对照组, 每组64例. 对照组给予常规西药药物治疗, 观察组在此基础上给予桑苏饮加味治疗, 共7 d. 比较两组治疗后的临床疗效、排痰情况及痰潴留、肺不张发生率, 比较两组治疗前后的中医证候评分量表 (TCMSSS) 评分、肺功能 [第1秒用力呼气容积 (FEV1 )、用力肺活量 (FVC)、FEV1/FVC、最大呼气流量 (PEFR) ]、中文版世界卫生 组织生存质量量表简表 (WHOQOL-BREF) 评分及血清肿瘤坏死因子α (TNF-α)、白细胞介素6 (IL-6)、白细胞介素10 (IL-10) 水平. 结果 观察组治愈 56 例 (87. 50%)、有效 7 例 (10. 94%)、无效 1 例 (1. 56%), 对照组分别为 43 例 (67. 19%)、15例 (23. 44%)、6例 (9. 38%), 观察组治愈率明显高于对照组 (P<0. 01). 观察组治疗后咳痰次数、每次 咳痰量、咳痰时间及痰潴留发生率均低于对照组, 每次咳痰量高于对照组 (P均<0. 05). 两组治疗后肺不张发生率 比较无统计学差异 (P>0. 05). 与治疗前比较, 两组治疗后 FEV1、FVC、FEV1/FVC、PEFR及 WHOQOL-BREF各领域 评分均升高, TCMSSS中的发热、咳嗽、痰量、胸闷、喘息、啰音评分及血清TNF-α、IL-6、IL-10水平均降低, 且观察组变 化更明显 (P均<0. 05). 结论 桑苏饮加味可减轻肺切除术后患者的炎症反应, 从而减轻其临床症状、减少痰液生 成、改善生活质量, 同时有助于预防痰潴留的发生. [ABSTRACT FROM AUTHOR]

BACKGROUND: Weightlessness can affect intraocular pressure and ocular structure changes. Methazolamide can reduce intraocular pressure, but its effect on intraocular pressure, retinal and choroid thickness in weightlessness is rarely reported. OBJECTIVE: To investigate the effect of the methazolamide on intraocular pressure and retinal and choroidal thickness in rats with simulated microgravity for 2 weeks. METHODS: Sixteen healthy Sprague-Dawley rats were randomly divided into two groups: control group (n=8) and drug group (n=8). A model of simulated microgravity environment was established in each rat by -30° tail suspension method. All the rats were not treated before tail suspension, and intragastrically given normal saline and methazolamide saline solution in the two groups respectively after tail suspension, once a day, for 14 continuous days. iCare tonometer was used to measure the changes of intraocular pressure in tail-suspended rats before tail suspension and 1, 3, 7, and 14 days after tail suspension. EDI SD-OCT was used to measure the changes of retinal and choroidal thickness in tail-suspended rats before tail suspension and 1, 3, 7, and 14 days after tail suspension. The study protocol was approved by the Animal Experiment Ethics Committee of the PLA Strategic Support Force Characteristic Medical Center. RESULTS AND CONCLUSION: Intraocular pressure in the control group increased after tail suspension, which was significantly higher at 14 days after tail suspension than the baseline (P < 0.05) as well as significantly higher at 7 days than 23 days after tail suspension (P < 0.05). In the drug group, there was no significant difference in the intraocular pressure before and after tail suspension (P > 0.05). Compared with the control group, the intraocular pressure was significantly reduced in the drug group (P < 0.05). Retinal thickness showed no significant changes in each group before and after tail suspension (P > 0.05), and there was also no significant difference between the two groups (P > 0.05). In the control group, choroidal thickness was increased after tail suspension, and became thicker at 3 days than 1 day after tail suspension (P < 0.05). However, there was no significant difference at 7 and 14 days after tail suspension (P > 0.05). In the drug group, choroidal thickness was increased after tail suspension, which was significantly increased at 3, 7, 14 days compared with 1 day after tail suspension (P < 0.05). However, there was no significant difference at 3 days and 7, 14 days after tail suspension (P > 0.05). Compared with the control group, the choroidal thickness was significantly reduced in the drug group (P < 0.05). To conclude, 2-week simulated microgravity has a significant effect on the rat’s intraocular pressure. With the extension of tail suspension time, the intraocular pressure is increased and become significantly elevated at 14 days after tail suspension. The use of methazolamide can effectively inhibit the elevation of intraocular pressure. Moreover, 2-week simulated microgravity has no obvious effect on the retinal thickness, but has a significant effect on the choroidal thickness of rats. With the extension of tail suspension time, the choroidal thickness is increased, while the use of methazolamide can effective reduce the increase in choroidal thickness. [ABSTRACT FROM AUTHOR]

雄激素性脱发（androgenetic alopecia, AGA）是一种常见的脱发疾病，其特征是额颞部和头顶部毛囊微型化。AGA 虽 然是一种良性疾病，但是对患者的外貌和心理会带来严重的影响。近年来，对脱发药物的研究成为 AGA 治疗的热点问题。笔者 概述了 AGA 的发病机制，并对 AGA 治疗药物的新进展作一综述。 [ABSTRACT FROM AUTHOR]

Geosynthetic clay liner (GCL) is a new type of material commonly used for lake bottom seepage prevention, but if the roots of lake aquatic plants penetrate into GCL, it will affects its seepage prevention effect. In order to explore the influence of GCL􀆳s hydraulic conductivity under the penetration of plant roots, model tests were carried out on plants such as Thalia dealbata, reed, and cattail, global digital systems (GDS) geoenvironmental permeameter was used to test the hydraulic conductivity of GCL after the penetration of aquatic plant roots. The results show as follows. Under the same confining pressure, with the increases of the penetration rate of plant roots, the GCL hydraulic conductivity under the penetration of Thalia dealbata, reed and cattail roots gradually increase, and the maximum increases to 10 -7 m/ s. When the root penetration rate is greater than 1%, the GCL hydraulic conductivity of withered roots is about 1. 26 ~3. 13 times that of the normal roots morphology. The withered roots have a more significant impact on GCL permeability than the normal root morphology. The roots of cattails and reeds have similar effects on the hydraulic conductivity of GCL, while the roots of Thalia dealbata have little effect on the hydraulic conductivity of GCL. [ABSTRACT FROM AUTHOR]

The experiment was to investigate the effect of spraying and fanning on donkey foals' serum biochemical indexes, antioxidant function and relative gene expression levels in summer, to provide reference for welfare management of donkey foals in summer. 24 healthy donkey foals with similar day-old of (51.95±2.24) d and body weight of (56.80±5.34) kg were selected and divided into four groups, with six replicates (half male and half female) in each group, and one donkey in each replicate. The test was divided into control group, spraying group, fanning group and spraying-fanning group. The experiment lasted for 28 d. The results showed that compared with control group, the donkey foals' serum activity of ALP, AST and LDH in fanning group and spraying-fanning group were extremely reduced (P<0.01), and the serum CRE content in test groups were significantly reduced (P<0.05). Compared with control group, the donkey foals' serum activity of GSH-Px in fanning group and spraying-fanning group was significantly increased (P<0.05), and the MDA content was significantly reduced (P<0.05), and the serum activity of CAT and T-SOD in test groups was significantly increased (P<0.05). Compared with control group, the relative expression levels of CAT, GSH-Px3, SOD1 and SOD2 genes in white blood cells of foals in fanning group and spraying-fanning group were significantly increased (P<0.05). The experiment indicates that spraying and fanning can alleviate the effect of high temperature environment on serum biochemical indexes of donkey foals, improve the activity of antioxidant enzymes in serum, reduce the content of MDA, and upregulate the relative expression of antioxidant related. The effect of fan treatment is relatively good. [ABSTRACT FROM AUTHOR]

Most of traditional reliability models for traditional mechanical products ignore the oscillation characteristics of probability density caused by periodic faults, which affects the accuracy of the models. The reliability model of the exponential attenuation oscillation distribution and the corresponding reliability, failure rate, and average life calculation models are constructed on the basis of the traditional life model. Then, the effect of parameters including the attenuation coefficient, oscillation amplitude, oscillation angular frequency on the probability distribution characteristics is studied. As an example, the failure time data of automatic transmission of a forklift truck are fitted with the proposed probability distribution model. And the fitting results are compared with those of the exponential distribution model, the three‑parameter Weibull model and the bathtub‑shaped curve model. The results show that the probability model can better describe the probability distribution characteristics of the fault‑free working time of automatic transmission, and the model can obtain a smaller root mean square error. [ABSTRACT FROM AUTHOR]

Objective To discuss the effect of G-protein-coupled receptor 49 (GPR49) gene on proliferation and invasive ability of hepatoma cell line Huh7 and its molecular biological mechanism. Methods According to the different transfected small interfering RNA (si-RNA), Huh7 cells were divided into the GPR49-siRNA (si-GPR49) group and the NC-siRNA (si-NC) group. Untransfected Huh7 cells were set as the control group. Messenger RNA (mRNA) and protein expression of GPR49, cyclin D1 and matrix metalloproteinase 9 (MMP9) in the cells of the three groups were respectively detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot method. The proliferation and invasive ability of the cells of each group were respectively detected by MTT method and Transwell method. Results The relative expression of GPR49 mRNA of the si-GPR49 group was (23.8 ±3.1)% of the control group (P <0.05). Compared with the control group,the protein expression of GPR49, cyclin D1 and MMP9 of the si-GPR49 group decreased significantly (all in P <0.05). The proliferation experiment results by MTT indicated that the optical density(OD) of the cells of the si-GPR49 group at 72 h was (0.53 ±0.12), which was significantly lower than that of the control group (1.35 ±0.28). The difference had statistical significance (P <0.05). The average invaded cell counts of the si-GPR49 group were (13.6 ±2.5), which was significantly lower than (65.3 ±6.1) of the control group. The difference had statistical significance (P <0.05 ). Conclusions GPR49-siRNA may inhibit the gene expression of GPR49 in Huh7 cells. Its mechanism may be that the proliferation of Huh7 cells is inhibited by reducing the level of cyclin D1; the migration and invasive ability of Huh7 cells is inhibited by affecting the expression level of MMP9. [ABSTRACT FROM AUTHOR]