283 results on '"tos ferina"'
Search Results
252. [Pertussis vaccine. Reemergence of the disease and new vaccination strategies].
- Author
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Moraga-Llop FA and Campins-Martí M
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Humans, Infant, Middle Aged, Young Adult, Communicable Diseases, Emerging epidemiology, Communicable Diseases, Emerging prevention & control, Pertussis Vaccine, Vaccination, Whooping Cough epidemiology, Whooping Cough prevention & control
- Abstract
Pertussis continues to be a public health problem despite the significant decrease in its incidence due to routine vaccination. Resurgence of the disease in countries that have maintained high vaccination coverage has been observed in recent years. Although vaccination is the most effective preventive control measure, both natural and artificial immunity wane over time, and thus the protection offered by current vaccines is not long-lasting. Furthermore, acellular vaccines are less effective. The implementation of new vaccine strategies is required. Vaccination of pregnant women is the most effective strategy for preventing pertussis in young infants, who are the most vulnerable, and should be recommended together with cocooning, ie vaccination of future household and extra-domiciliary contacts who are the main transmitters of the disease., (Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
253. Pertussis epidemic despite high levels of vaccination coverage with acellular pertussis vaccine.
- Author
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Sala-Farré MR, Arias-Varela C, Recasens-Recasens A, Simó-Sanahuja M, Muñoz-Almagro C, and Pérez-Jové J
- Subjects
- Adolescent, Adult, Bordetella pertussis isolation & purification, Child, Child, Preschool, Contact Tracing, Family Characteristics, Female, Humans, Immunization, Secondary, Incidence, Infant, Male, Population Surveillance, Schools, Spain epidemiology, Vaccines, Acellular, Whooping Cough prevention & control, Whooping Cough transmission, Young Adult, Diphtheria-Tetanus-acellular Pertussis Vaccines, Disease Outbreaks, Vaccination statistics & numerical data, Whooping Cough epidemiology
- Abstract
Introduction: We describe the pertussis epidemic, based only on confirmed whooping cough cases. We have analyzed data on the diagnosis, epidemiology and vaccine history in order to understand the factors that might explain the trends of the disease., Methods: A descriptive study of the confirmed pertussis cases reported during 2011 in the Vallès region (population 1,283,000). Laboratory criteria for confirmed pertussis cases include isolation of Bordetella pertussis from a clinical specimen or detection of B. pertussis by PCR in nasopharyngeal swabs., Results: A total of 421 pertussis confirmed cases were reported, which was the highest incidence reported in the last decade (33 cases/100,000 people/year in 2011). The highest incidence rate was among infants less than 1 year old (448/100,000), followed by children 5-9 years old (154/100,000). Pertussis cases aged 2 months-1 year were 90% vaccinated following the current DTaP schedule for their age group in Catalonia, and cases of 5-9 years were 87% fully vaccinated with 5 doses of DTaP vaccine. There were no deaths, although 8% of cases were hospitalized. Pertussis was more severe in infants, 30% required hospitalization despite having received the vaccine doses corresponding to their age. Children of 5-9 years were most often identified as primary cases in households or school clusters., Conclusion: Despite high levels of vaccination coverage, pertussis circulation cannot be controlled at all. The results question the efficacy of the present immunization programmes., (Copyright © 2013 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
254. [Hospitalization due to whooping cough in Spain (1997-2011)].
- Author
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Fernández-Cano MI, Armadans-Gil L, Alvarez-Bartolomé M, Rodrigo-Pendás JÁ, and Campins-Martí M
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- Adolescent, Adult, Aged, Child, Child, Preschool, Costs and Cost Analysis, Female, Hospitalization economics, Humans, Infant, Male, Middle Aged, Retrospective Studies, Spain epidemiology, Time Factors, Whooping Cough epidemiology, Whooping Cough therapy, Young Adult, Hospitalization statistics & numerical data, Whooping Cough economics
- Abstract
Introduction: Pertussis incidence has increased in recent years in countries with high vaccination coverage. The aim of this study was to determine the health impact of pertussis in Spain in the period 1997-2011 in relation to hospitalizations, mortality, and associated costs., Methods: We retrospectively analyzed hospital discharges included in the Minimum Data Set (MDS) in Spain for the period 1997-2011, with a primary or secondary diagnosis related to pertussis. We calculated incidence rates of hospitalization for pertussis (per 100,000) per year, by age group and by Autonomous Region, along with the mortality and lethality rates., Results: A total of 8,331 hospital discharges with a diagnosis of pertussis were recorded in Spain between 1997 and 2011. The overall incidence of pertussis hospitalizations was 1.3 cases per 100,000 inhabitants. The large majority (92%) of hospitalizations occurred in children under one year of age, with an incidence of 115.2 hospitalizations per 100,000. There were 47 deaths, 37 (79%) in the group of children under 1 year and 6 (13%) in the group older than 65 years. The estimated cost of hospitalization for pertussis was 1,841 euros., Conclusion: The epidemiology of severe cases of pertussis, and its clinical and economic impact, confirms the need to modify the vaccination strategies for Spain to achieve more effective control in the most vulnerable groups., (Copyright © 2013 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
- Published
- 2014
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255. Aspects clinico-épidémiologiques de l'épidémie de coqueluche en 1996 à Bucarest, Roumanie
- Author
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M. Luminos, M. Dragan, Victoria Aramă, E. Benea, L. Dorasteanu, St.S. Arama, and M. Podani
- Subjects
Gynecology ,medicine.medical_specialty ,Infectious Diseases ,business.industry ,medicine ,medicine.disease ,business ,Tos ferina ,Whooping cough - Published
- 1997
256. [Clinical and epidemiological differences between Bordetella pertussis and respiratory syncytial virus infections in infants: a matched case control study].
- Author
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Giménez-Sánchez F, Cobos-Carrascosa E, Sánchez-Forte M, López-Sánchez MÁ, González-Jiménez Y, and Azor-Martínez E
- Subjects
- Case-Control Studies, Female, Humans, Infant, Male, Patient Admission, Retrospective Studies, Respiratory Syncytial Virus Infections diagnosis, Respiratory Syncytial Virus Infections epidemiology, Whooping Cough diagnosis, Whooping Cough epidemiology
- Abstract
Introduction: An increase in cases of pertussis, mainly in young infants, has been reported in the last few years. The clinical presentation of this disease is very similar to that produced by respiratory syncytial virus (RSV), which makes the diagnosis difficult., Objective: To compare the clinical and epidemiological characteristics between Bordetella pertussis and RSV infections in infants admitted to hospital., Material and Methods: An analytical matched case-control study was conducted during the period 2008-2011. Cases were defined as infants admitted with pertussis confirmed by PCR in nasopharyngeal aspirate. Each case was matched by age, sex and date of admission to two controls defined as patients with RSV infection detected by immunochromatography in nasal aspirate. Demographic, clinical, laboratory data were compared., Results: Seventy eight patients (26 cases of pertussis and 52 controls RSV+) were included. Sociodemographic characteristics were similar in both groups. Cases had more days of symptoms prior to admission, longer hospital stays, and increased frequency of epidemic family environment. Apnoea and cyanosis were more frequent. Cases of pertussis were more likely to have apnoea, cyanosis, and lymphocytosis while RSV infections had more frequent fever, vomiting and respiratory distress., Conclusions: The clinical presentations of pertussis and RSV infection are similar, but there are some characteristics that can help to distinguish between them., (Copyright © 2013 Elsevier España, S.L. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
- Published
- 2014
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257. [Pertussis in fully vaccinated infants and children. Are new vaccination strategies required?].
- Author
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Moraga-Llop FA, Mendoza-Palomar N, Muntaner-Alonso A, Codina-Grau G, Fàbregas-Martori A, and Campins-Martí M
- Subjects
- Adolescent, Child, Child, Preschool, Humans, Infant, Retrospective Studies, Whooping Cough diagnosis, Whooping Cough therapy, Pertussis Vaccine administration & dosage, Whooping Cough prevention & control
- Abstract
Objective: To analyse the vaccination status of children diagnosed with pertussis and to compare the clinical manifestations of fully vaccinated with unvaccinated, or incompletely-vaccinated, children., Methods: The clinical histories and vaccination cards of patients under 16years of age seen in the Emergency Room of the University Hospital Vall d'Hebron, Barcelona (Spain), for pertussis confirmed by a microbiological study were reviewed. The study period lasted from January 1, 2009 to December 31, 2011., Results: Two hundred and twelve cases were studied: 35 in 2009, 28 in 2010 and 149 in 2011. RT-PCR was positive in 210 patients, and 73 had a positive culture. Infants under 6months of age account for 36.8% of all cases. Forty-four patients (21.5%) were not vaccinated. Forty-four (21.5%) children were between 2 and 5months of age and had received 1-2vaccine doses. One hundred and seventeen (57%) children were fully vaccinated; 76.9% (90cases) had received the last dose less than 4years ago. When clinical manifestations of the fully vaccinated patients were compared with those of the non-vaccinated or incompletely-vaccinated children, only cyanosis was found with a higher frequency in the latter group (P<.001). The age-adjusted probability of hospitalisation was significantly associated with non-vaccination (P=.001). The case mortality rate among inpatients was 1.3%., Conclusions: The number of pertussis cases seen in our centre has risen significantly in the last year. More than half (57%) of the patients were fully vaccinated, and 76.9% had received the last dose in the previous 4years. Other vaccination strategies, such as vaccination of adolescents, adults, and pregnant women, as well as a cocoon strategy are required to protect infants under 6months of age. More effective vaccines need to be developed., (Copyright © 2012 Elsevier España, S.L. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
- Published
- 2014
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258. [Contact tracing of paediatric pertussis cases at a tertiary hospital in Barcelona, Spain].
- Author
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Uriona Tuma SM, Martínez Gómez X, Campins Martí M, Codina Grau G, Ferrer Marcelles A, Rodrigo Pendás JÁ, Pinós Tella L, Cebrian R, and Moraga Llop FA
- Subjects
- Age Distribution, Bacterial Typing Techniques, Bordetella pertussis classification, Bordetella pertussis isolation & purification, Child, Child, Preschool, Cross-Sectional Studies, Family, Female, Friends, Humans, Infant, Male, Pertussis Vaccine, Prevalence, Retrospective Studies, Risk, Spain epidemiology, Time Factors, Vaccination statistics & numerical data, Whooping Cough microbiology, Whooping Cough transmission, Contact Tracing, Hospitals, University statistics & numerical data, Tertiary Care Centers statistics & numerical data, Whooping Cough epidemiology
- Abstract
Background and Objectives: Pertussis remains an important cause of morbimortality despite current vaccination strategies. This study was designed to describe the results and characteristics of close contacts of pertussis cases diagnosed in children less than 16 years in a tertiary hospital in Barcelona., Patients and Methods: Cross-sectional study. Data were collected from chart review of contacts of paediatric cases of pertussis in Vall d'Hebron University Hospital from 2005 to 2009. Only patients with microbiological study done were included. The odds ratio (OR) and 95% confidence interval (95% CI) were calculated as association measure., Results: Ninety-one index cases and 404 contacts were studied. The prevalence of positive cases among contacts was 33.2%. Contacts of index cases younger than 6 months had a higher risk of being positive for pertussis than contacts of older children (OR: 3.38; 95% CI: 1.88-6.10). Primary cases were identified as 16.7% of the contacts studied, who were the source of infection for 67.7% of index cases younger than 6 months and for 26.9% of older index cases., Conclusions: Contact tracing of paediatric pertussis cases is a necessary clinical activity. It is more likely to find primary cases in the contact investigation of children less than 6 months. Preventive strategies should be targeted primarily to frequent contacts of this age group., (Copyright © 2012 Elsevier España, S.L. All rights reserved.)
- Published
- 2013
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259. [Situation of pertussis in Valencian Community: an epidemic revival?].
- Author
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Gil-Tomás JJ, Colomina-Rodríguez J, Martínez-Macías O, Borrás-Máñez M, and Guerrero-Espejo A
- Subjects
- Adolescent, Child, Child, Preschool, DNA, Bacterial, Humans, Incidence, Infant, Infant, Newborn, Polymerase Chain Reaction, Spain epidemiology, Whooping Cough epidemiology
- Abstract
Introduction: Pertussis is a highly contagious vaccine-preventable disease. An increasing incidence has been reported in several countries around the world in the last few years. The aim of this study is to analyze the situation of pertussis in the Valencian Community (Spain), with the purpose of verifying the increased incidence of the illness., Methods: A descriptive analysis of probable and confirmed cases detected during 2011 was conducted. Methods used for Bordetella pertussis detection from clinical samples were: culture isolation, polymerase chain reaction (PCR)-based detection of bacterial DNA, and/or detection of specific IgM antibodies. The disease incidence and other epidemiological variables were estimated. These results were compared to data collected in previous years (2008-2010). The Epidemiological Surveillance Analysis and Microbiological Surveillance Network integrated systems of the regional Department of Health were used as sources of information., Results: In 2011, 249 cases of pertussis were detected (incidence rate of 4.89×10(5) inhabitants). This rate is statistically significantly higher than those reported in 2008 (0.73×10(5) inhabitants), 2009 (0.53×10(5) inhabitants), and 2010 (0.53×10(5) inhabitants). The highest incidence rate was observed in cases younger than one year old (252.97×10(5) inhabitants), with marked differences compared to the rest of age groups. More than two-thirds (69%) of reported cases were confirmed by a laboratory test. Detection of specific serum IgM antibodies was positive in 10% of cases, culture isolation was positive in 17%, and PCR-based detection of bacterial DNA in 35% of cases., Conclusions: The results of this study show a clear increase of pertussis incidence in the Valencian Community during 2011., (Copyright © 2012 Elsevier España, S.L. All rights reserved.)
- Published
- 2013
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260. [Clinical and epidemiological features of pertussis among hospitalized infants in Seville during 2007-2011].
- Author
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Hurtado-Mingo A, Mayoral-Cortés JM, Falcón-Neyra D, Merino-Díaz L, Sánchez-Agüera M, and Obando I
- Subjects
- Female, Hospitalization statistics & numerical data, Humans, Infant, Male, Retrospective Studies, Spain epidemiology, Time Factors, Whooping Cough diagnosis, Whooping Cough epidemiology
- Abstract
Introduction: Despite routine pertussis immunization, pertussis burden remains high, especially among infants. The aim of this study was to describe epidemiologic, clinical and outcome features in pediatric patients admitted to a tertiary hospital in Andalusia (Southern Spain) with confirmed Bordetella pertussis infection., Methods: Retrospective descriptive study based on a review of medical records for all pediatric patients admitted to Hospital Universitario Virgen del Rocío (Sevilla) between January 1, 2007 and December 31, 2011., Results: Overall, 39 patients were diagnosed with pertussis during the study period with significant higher incidence rate in 2011 compared to 2007 (p=0.0003). Eleven children were admitted to the pediatric intensive care unit (ICU) in 2010 and 2011 and two of them died. Patients who were admitted to ICU presented with more atypical disease compared to controls in a conventional ward. They were less likely to have pertussoid cough and clinical diagnosis at admission and had a smaller percentage of lymphocytes. Creactive protein values were higher and they had a longer duration of hospital stay., Conclusion: The pertussis incidence rate increased significantly among hospitalized infants during the study period, and was associated with severe morbidity, including unusual complications, and mortality. A higher awareness of the clinical diagnosis of pertussis among infants admitted to ICU is required due to more atypical manifestations, and the risk of sudden deterioration associated to fatal outcome., (Copyright © 2012 Elsevier España, S.L. All rights reserved.)
- Published
- 2013
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261. Le diagnostic bactériologique des infections à Bordetella
- Author
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Jean Michel Alonso
- Subjects
Bordetella pertussis ,Bordetella bronchiseptica ,Bordetella avium ,biology ,Systematic bacteriology ,biology.organism_classification ,medicine.disease ,Bordetella parapertussis ,Microbiology ,Bordetella ,Infectious Diseases ,medicine ,Tos ferina ,Whooping cough - Abstract
Resume L'isolement des Bordetella doit etre pratique a une phase precoce de l'infection, car ces bacteries sont expulsees de l'epithelium respiratoire des la survenue des signes cliniques de la phase d'etat, notamment les acces de toux paroxystique dans le cas de la coqueluche. L'identification de B. pertussis repose sur un examen microscopique attentif, la capacite de croitre sur milieu de Bordet Gengou au sang mais non pas, a l'isolement, sur gelose ordinaire, l'aspect des colonies en «gouttelettes de mercure et entourees d'une zone d'hemolyse, n'apparaissant qu'apres 72 h. B. parapertussis est hemolytique et urease +. B. bronchiseptica pousse sur gelose ordinaire et est mobile, possede une urease, une nitrate reductase et utilise le citrate comme source unique de carbone. B. avium se distingue essentiellement de B. bronchiseptica par l'absence d'urease et de nitrate reductase.
- Published
- 1986
262. Long term respiratory sequelae of whooping cough in a nationally representative sample
- Author
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J Wadsworth and Nicky Britten
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Whooping Cough ,Respiratory Tract Diseases ,Peak Expiratory Flow Rate ,medicine ,Humans ,Longitudinal Studies ,Health and development ,Respiratory system ,Intensive care medicine ,Lung function ,Whooping cough ,General Environmental Science ,business.industry ,General Engineering ,Sequela ,General Medicine ,respiratory system ,Prognosis ,bacterial infections and mycoses ,medicine.disease ,Health Surveys ,United Kingdom ,respiratory tract diseases ,Chronic cough ,Chronic disease ,Cough ,Chronic Disease ,General Earth and Planetary Sciences ,Female ,medicine.symptom ,Tos ferina ,business ,Research Article - Abstract
The long term respiratory consequences of whooping cough in childhood were sought among members of the National Survey of Health and Development. Peak expiratory flow rate was measured when the survey members were 36 years old and seven respiratory symptoms were reported at the same time. Peak expiratory flow rate was slightly reduced in those who had had whooping cough as a child, and this difference became non-significant when other factors were taken into account. Unexpectedly, chronic cough was significantly less likely to be reported by those who had had whooping cough, and this difference remained significant only among men after other factors had been taken into account. This study failed to show a long term detrimental effect of whooping cough on the respiratory system.
- Published
- 1986
263. Laboratory diagnosis of pertussis
- Author
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Steven G. F. Wassilak and Ida M. Onorato
- Subjects
DNA, Bacterial ,Microbiology (medical) ,Bordetella pertussis ,Whooping Cough ,Fluorescent Antibody Technique ,Enzyme-Linked Immunosorbent Assay ,Immunoglobulin G ,Serology ,Agglutination Tests ,medicine ,Humans ,Serologic Tests ,Virulence Factors, Bordetella ,Whooping cough ,Antigens, Bacterial ,biology ,business.industry ,Respiratory disease ,Immunoglobulin A.secretory ,medicine.disease ,biology.organism_classification ,Antibodies, Bacterial ,Infectious Diseases ,Immunoglobulin A, Secretory ,Pediatrics, Perinatology and Child Health ,Immunology ,biology.protein ,Antibody ,business ,Tos ferina ,Adenylyl Cyclases - Published
- 1987
264. Sensitivity and specificity of clinical case definitions for pertussis
- Author
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R J Biellik, P R Silverman, D G Burstyn, Jeffrey P. Davis, C R Manclark, G Sanden, Peter A. Patriarca, and P D Mitchell
- Subjects
Gerontology ,medicine.medical_specialty ,Adolescent ,Whooping Cough ,Enzyme-Linked Immunosorbent Assay ,Sensitivity and Specificity ,Disease Outbreaks ,Serology ,Wisconsin ,Internal medicine ,Epidemiology ,Humans ,Medicine ,Serologic Tests ,Child ,Whooping cough ,Respiratory illness ,business.industry ,Public Health, Environmental and Occupational Health ,Outbreak ,Delaware ,medicine.disease ,Child, Preschool ,Clinical case ,Epidemiologic Methods ,business ,Tos ferina ,Research Article - Abstract
We evaluated the diagnostic performance of 15 clinical case definitions for pertussis in 233 patients who developed acute respiratory illness during community outbreaks in Wisconsin and Delaware. Using results from culture (Regan-Lowe media) and serology (Ig-class-specific ELISA) as diagnostic standards, cough for greater than or equal to 14 days was both sensitive (84 per cent-92 per cent) and specific (63 percent-90 per cent) in identifying patients with pertussis. This definition may be useful in monitoring pertussis outbreaks and for investigating contacts of culture-positive cases.
- Published
- 1988
265. The return of pertussis
- Author
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James W. Bass and Stephen R. Stephenson
- Subjects
Adult ,Pertussis Vaccine ,Microbiology (medical) ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Whooping Cough ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,United States ,Surgery ,Infectious Diseases ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Epidemiology ,medicine ,Humans ,Child ,business ,Tos ferina ,Whooping cough - Published
- 1987
266. Últimos avances médicos presentados ante la 93ª sesión anual de la Asociación Médica Americana en Atlantic city, Estados Unidos, junio 8 a junio 12 de 1942. Contribuciones latino-americanas
- Author
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Mera, Benjamín
- Subjects
lcsh:R5-920 ,Medicina ,Medicina tropical ,lcsh:R ,alcoholismo crónico ,lcsh:Medicine ,Patología ,sífilis ,tumores óseos ,tos ferina ,Fisiología ,Higiene pública ,hipertensión arterial ,lepra ,salud pública ,tuberculosis ,control de nacimientos ,anoxemia ,reumatismo cardíaco ,lcsh:Medicine (General) ,fiebre amarilla selvática ,dermatología - Abstract
Una sinopsis de los hechos más notables presentados a la Asociación Médica Americana como fruto del trabajo de investigadores de diversas partes del Hemisferio Occidental, reviste la mayor importancia para la información de los profesionales colombianos. Datos generales, y en lo posible lo más concisos, se dan en este resumen sobre trabajos personalmente seleccionados de Medicina General, Patología, Fisiología, Medicina Tropical e Higiene Pública, los cuales fueron presentados o exhibidos ante los 8.103 médicos que asistieron a la Convención médica más importante de los tiempos actuales.
- Published
- 1942
267. Concordancia entre las técnicas de IFD, PCR y ELISA para determinar la frecuencia de Bordetella parapertussis y Bordetella pertussis en un brote de tos ferina en el departamento de Antioquia (Colombia) en 2013
- Author
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Fabiola Rojas-Baquero, Adriana Paola Ulloa-Virgüez Ulloa-Virgüez, and Efraín Andrés Montilla-Escudero
- Subjects
0301 basic medicine ,Microbiology (medical) ,Bordetella pertussis ,medicine.medical_specialty ,Bordetella parapertussis ,030106 microbiology ,Population ,Gastroenterology ,Microbiology ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Enzyme-linked immunosorbent assay ,Nasopharyngeal aspirate ,Internal medicine ,Reacción en cadena de la polimerasa ,medicine ,Tos ferina ,Pharmacology (medical) ,lcsh:RC109-216 ,education ,Direct fluorescent antibody ,Inmunofluorescencia directa ,Whooping cough ,education.field_of_study ,biology ,lcsh:RM1-950 ,Outbreak ,Ensayo por inmunoabsorción ligado a enzimas ,biology.organism_classification ,medicine.disease ,Polymerase chain reaction ,Bordetella ,Infectious Diseases ,Geography ,lcsh:Therapeutics. Pharmacology ,Direct immunofluorescence - Abstract
Objetivo: Obtener la concordancia de técnicas diagnósticas y confirmar el diagnóstico de los casos probables de tos ferina captados por inmunofluorescencia directa (IFD) durante un brote en 2013 en el departamento de Antioquia. Materiales y métodos: Se analizaron los datos demográficos, clínicos, epidemiológicos y de resultados de laboratorio de casos probables de tos ferina confirmados por IFD en un pico de tos ferina en 2013 en el departamento de Antioquia. Las muestras de aspirado nasofaríngeo y suero fueron recolectadas y recibidas entre los periodos epidemiológicos IV - VII de 2013. Todos los pacientes confirmados por IFD fueron confirmados por PCR o ELISA. El análisis de concordancia se realizó por índice kappa. Resultados: De las 180 muestras procesadas en el LSP de Antioquia, 134 (74%) fueron positivas por la técnica de IFD, de las cuales se confirmaron por PCR 109 muestras con 24 (22%) positivas para B. parapertussis , 3 (2,8%) para B. pertussis , 17 (15,6%) para Bordetella spp. y 18 (16,5%) con infección mixta por B. pertussis y B. parapertussis . De 81 casos que se confirmaron por ELISA, 31 (38,3%) fueron positivos. En el municipio de La Estrella la edad media de los casos confirmados fue de 6,6 años y la mediana de 3 años (rango: 2-4 años). Con respecto a los casos del municipio de Medellín, la edad media fue de 28,7 años y la mediana de 25 años (rango: 12-42 años). En su mayoría, en los síntomas no hubo diferencias significativas, excepto para la tos paroxística entre los casos confirmados de B. parapertussis y B. pertussis (p =
268. Tos ferina neonatal, una enfermedad emergente
- Author
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Jaime Alberto Mesa, Ángela María Albán, Fabio Ernesto Arcos, Juan Manuel Vasquez-Jimenez, and Freddy Andrés Barrios
- Subjects
Microbiology (medical) ,Gynecology ,medicine.medical_specialty ,Whooping cough ,business.industry ,Leukocytosis ,Immunofluorescence ,Vaccination ,Vacunación ,Inmunofluorescencia ,Infectious Diseases ,Pertussis ,Medicine ,Tos ferina ,Pharmacology (medical) ,Tos paroxística ,business ,Leucocitosis - Abstract
ResumenLa tos ferina es una enfermedad del tracto respiratorio superior que ha incrementado últimamente su incidencia. Se ha demostrado que los adultos son la principal fuente de transmisión para los niños susceptibles. En la actualidad, la enfermedad afecta con más frecuencia a los niños menores de 3 meses, entre los cuales, los menores de 1 mes tienen mayor riesgo de complicaciones y letalidad.Se presenta un caso autóctono de una recién nacida de 16 días con episodios de tos quintosa, cianosante y emetizante, cuadro hemático que evidencia leucocitosis y linfocitosis, que se originó en un área donde está implementada, como política de salud pública, la vacunación para tos ferina en niños. La paciente tuvo una evolución tórpida complicada con convulsiones y necesidad de ventilación mecánica. Se identificó en la paciente Bordetella pertussis por inmunofluorescencia, reacción en cadena de la polimerasa y cultivo. Se hace una breve revisión de la literatura, haciendo énfasis en el panorama actual de la vacunación en neonatos.AbstractNeonatal pertussis is an upper respiratory tract infection whose incidence has recently increased. Adults have been demonstrated to be the main source for neonatal infection, accounting for the rising rates of disease in this later population group. Currently, the disease affects chiefly infants under three months of age, among which, those younger than one moth have the highest rates of complication and death.Here we present an indigenous case of a 16 days old newborn that arose in an area where pertussis vaccination during the first months of life is the rule and very few cases had been documented throughout the last years. The patient presented whooping cough with cyanosis and emesis episodes, whose complete blood count showed markedly and increasingly high leukocytosis and lymphocytosis. Her clinical course complicated with seizures and required mechanical ventilation. B. pertussis was demonstrated by means of immunofluorescence, polymerase chain reaction and culture. A brief literature review is made with emphasis on current landmarks on pertussis vaccination.
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269. XVIII Conferencia : Tos ferina
- Author
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Sánchez Avella, Liborio A., Cruz Paris, Jorge de la, Sánchez Avella, Liborio A., and Cruz Paris, Jorge de la
- Abstract
Enfermedad infectocontagiosa endémica, con brotes epidémicos, caracterizada por su típica evolución y sus accesos de tos en quintas, en uno de sus períodos evolutivos.
- Published
- 1958
270. La coqueluche : (tos ferina)
- Author
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Velasco, R, imp, Anonymous, Velasco, R, imp, and Anonymous
- Published
- 1892
271. How are the sub-unit pertussis vaccines to be evaluated?
- Author
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D. N. Baxter and A. C. C. Gibbs
- Subjects
medicine.medical_specialty ,Epidemiology ,Whooping Cough ,Unit (housing) ,Random Allocation ,Double-Blind Method ,Whooping-cough vaccine ,Medicine ,Humans ,Prospective Studies ,Intensive care medicine ,Whooping cough ,Pertussis Vaccine ,Clinical Trials as Topic ,business.industry ,Vaccination ,Age Factors ,medicine.disease ,Infectious Diseases ,Immunology ,business ,Tos ferina ,Mathematics ,Research Article ,Follow-Up Studies - Abstract
SUMMARYAlthough an effective whooping cough vaccine has been available in the UK since the 1950s, its current association with neurotoxicity has resulted in poor uptake: as a consequence major epidemics (with significant morbidity and mortality) arc still being experienced.Component (sub-unit) vaccines, which incorporate those antigens thought to be concerned with generating a protective effect, have been developed and are now available for field testing. This paper addresses how such a vaccine might be evaluated, the organization of a trial and the difficulties to be expected.
- Published
- 1987
272. Counterimmunoelectrophoresis in the diagnosis of whooping cough
- Author
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Stephen H. Gillespie and P C Boreland
- Subjects
Bordetella pertussis ,Counterimmunoelectrophoresis ,Whooping Cough ,Immunoelectrophoresis ,Pathology and Forensic Medicine ,Serology ,Antigen ,medicine ,Humans ,Serologic Tests ,Child ,Whooping cough ,Antigens, Bacterial ,medicine.diagnostic_test ,biology ,business.industry ,Respiratory disease ,Infant ,General Medicine ,medicine.disease ,biology.organism_classification ,Virology ,Child, Preschool ,Immunology ,business ,Tos ferina ,Research Article - Published
- 1984
273. Evaluation of the mouse model for study of encephalopathy in pertussis vaccine recipients
- Author
-
Erik L. Hewlett and J L Cowell
- Subjects
Hypersensitivity, Immediate ,Bordetella pertussis ,Immunology ,Encephalopathy ,Microbiology ,Mice ,Animal model ,medicine ,Animals ,Bovine serum albumin ,Whooping cough ,Pertussis Vaccine ,Antigens, Bacterial ,Brain Diseases ,biology ,business.industry ,medicine.disease ,biology.organism_classification ,Virology ,Disease Models, Animal ,Infectious Diseases ,biology.protein ,Pertussis vaccine ,Parasitology ,business ,Tos ferina ,medicine.drug ,Research Article - Abstract
Steinman et al. (...) described a reaction in mice receiving bovine serum albumin (BSA) and killed Bordetella pertussis organisms which appeared to involve the central nervous system. The response was interpreted as representing an encephalopathy and was proposed as a model for vaccine-associated events in DTP recipients. It is not appropriate at present, however, for this phenomenon to be considered a «model for pertussis vaccine encephalopathy» or for this protocol to be used to test the «encephalopathic potential» of pertussis vaccines
- Published
- 1989
274. Seasonal influences on pertussis
- Author
-
Jacqueline A Clarkson and Paul E. M. Fine
- Subjects
Pediatrics ,medicine.medical_specialty ,Time Factors ,Epidemiology ,Whooping Cough ,law.invention ,law ,Incidence data ,medicine ,Humans ,Child ,Whooping cough ,Pertussis Vaccine ,Wales ,business.industry ,Age Factors ,Infant ,General Medicine ,medicine.disease ,Natural history ,Transmission (mechanics) ,England ,Child, Preschool ,Seasons ,Tos ferina ,business ,Demography - Abstract
Both the absolute levels and the seasonal pattern of pertussis have changed over the past four decades in England and Wales. Three-to-four-year period epidemics tended to peak in the early or middle part of the year prior to 1957, during the last quarter between 1958 and 1975, and have been bimodal, with peaks in February and September, in both epidemics since 1976. Analysis of reported incidence data reveals similarities in the underlying seasonal pattern of transmission throughout this period. Seasonal effects include an increase in transmission coincident with the opening of schools in September. Other features of the pattern, such as a sharp fall in transmission in late November and a protracted low during February and March, are more difficult to explain, but may indicate important factors in the natural history of pertussis. The bimodality of recent epidemics appears to be a consequence of a seasonal low in transmission during February and March followed by a high level of transmission during the summer months. These seasonal trends may in turn reflect the increasing proportion of cases among pre-school children as a consequence of the fall in vaccine uptake during the mid 1970's.
- Published
- 1986
275. A double-blind clinical trial on diphenhydramine in pertussis
- Author
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C. Infante-Rivard, L. Chicoine, J. Lacroix, and A. Danzon
- Subjects
Bordetella pertussis ,Clinical Trials as Topic ,biology ,business.industry ,Whooping Cough ,Diphenhydramine ,Infant ,General Medicine ,medicine.disease ,biology.organism_classification ,Double blind study ,Clinical trial ,Double blind ,Double-Blind Method ,Anesthesia ,Pediatrics, Perinatology and Child Health ,medicine ,Humans ,Prospective Studies ,Tos ferina ,business ,Whooping cough ,medicine.drug - Published
- 1988
276. Pertussis vaccine and severe acute neurological illnesses. Response to a recent review by members of the NCES team
- Author
-
E.M. Ross, M.J.H. Wadsworth, and D.L. Miller
- Subjects
Pertussis Vaccine ,medicine.medical_specialty ,Brain Diseases ,General Veterinary ,General Immunology and Microbiology ,business.industry ,Encephalopathy ,Public Health, Environmental and Occupational Health ,medicine.disease ,Infectious Diseases ,Neurological Damage ,Seizures ,Immunology ,Acute Disease ,medicine ,Molecular Medicine ,Pertussis vaccine ,Humans ,Intensive care medicine ,Whole cell ,Tos ferina ,business ,Whooping cough ,medicine.drug - Abstract
Dr A.H. Griffith's article on this subject 1 raises some important issues which require comment. We, like him, regret the controversy over the safety and efficacy of whole cell pertussis vaccines over the last 15 years. It does indeed represent a sorry saga whose principal victims are children, many of whom have not been vaccinated against this unpleasant and sometimes dangerous illness because of fears over safety of the vaccine. The National Childhood Encephalopathy Study (NCES), was set up in 1976 as an independent scientific enquiry into severe acute neurological illnesses associated with pertussis vaccine in an attempt to help resolve the matter. The report on the results 2 concluded that these suggested, but did not prove, that the vaccine may very rarely cause the development of potentially damaging severe acute neurological illnesses in children who were previously apparently neurologically normal. Unfortunately the number of cases in the NCES was too small to allow any firm conclusions on whether or not the vaccine can cause permanent damage. The NCES has since been subject to intense scrutiny and criticism both by those who consider the vaccine can cause permanent neurological damage 3 and by those, such as Dr Griffith, who consider it does not. Regrettably, the controversy continues.
- Published
- 1989
277. The carrier state in pertussis
- Author
-
Gunilla Zackrisson, Birger Trollfors, Ingela Krantz, and Kjell Alestig
- Subjects
Microbiology (medical) ,Adult ,Male ,Bordetella pertussis ,General Immunology and Microbiology ,biology ,Adolescent ,business.industry ,Whooping Cough ,Carrier state ,General Medicine ,Middle Aged ,biology.organism_classification ,medicine.disease ,Infectious Diseases ,Healthy individuals ,Immunology ,Carrier State ,Medicine ,Humans ,Female ,Tos ferina ,business ,Close contact ,Whooping cough - Abstract
In order to determine whether healthy adults can be of importance for the spread of pertussis the nasopharyngeal flora of 391 healthy individuals working in close contact with children was investigated during the height of a pertussis epidemic. Only 1 carrier of Bordetella pertussis was found, even though all individuals were exposed to the organism during the study period through their work.
- Published
- 1986
278. Pertussis vaccines and permanent brain damage
- Author
-
Griffith Ah
- Subjects
Pertussis Vaccine ,General Veterinary ,General Immunology and Microbiology ,business.industry ,Public Health, Environmental and Occupational Health ,Brain damage ,medicine.disease ,Infectious Diseases ,Seizures ,Immunology ,medicine ,Molecular Medicine ,Pertussis vaccine ,Humans ,Brain Damage, Chronic ,medicine.symptom ,Tos ferina ,business ,Whooping cough ,medicine.drug - Published
- 1989
279. Impact of whooping cough on patients and their families
- Author
-
H R Anderson, M. Hill, H. P. Lambert, and I. D. A. Johnston
- Subjects
Male ,Parents ,Pediatrics ,medicine.medical_specialty ,Time Factors ,Whooping Cough ,Child Behavior ,Disease ,Life Change Events ,Quality of life ,medicine ,Humans ,Family ,Misinformation ,Whooping cough ,General Environmental Science ,business.industry ,General Engineering ,Infant ,General Medicine ,medicine.disease ,respiratory tract diseases ,Distress ,Child, Preschool ,Acute Disease ,Quality of Life ,General Earth and Planetary Sciences ,Female ,business ,Tos ferina ,Psychopathology ,Research Article - Abstract
The effects of whooping cough were studied in 21 children admitted to hospital with the disease and in their families. The illness caused considerable distress to both child and family. Parents suffered especially from fears for the life and health of their child and from serious loss of sleep. Two months after admission the child's behaviour was still disturbed, but in most cases the rest of the family had returned to normal. There was much misunderstanding and misinformation about whooping cough among both parents and doctors.
- Published
- 1985
280. Characteristics of Hospitalized Cases of Pertussis in Catalonia and Navarra, Two Regions in the North of Spain
- Author
-
Crespo, Inma, Todelo, Diana, Soldevila, Núria, Jordán García, Iolanda, Solano, Rubén, Castilla, Jesús, Caylà i Buqueras, Joan A., Godoy i García, Pere, Muñoz-Almagro, Carmen, Domínguez García, Àngela, Working Group on the Transmission of Pertussis in Households, Universitat de Barcelona, and Working Group on the Transmission of Pertussis in Households
- Subjects
Male ,Pediatrics ,Bordetella pertussis ,Apnea ,Whooping Cough ,lcsh:Medicine ,Logistic regression ,Hospital patients ,Risk Factors ,Vacunació ,Young adult ,Child ,lcsh:Science ,Aged, 80 and over ,Pertussis Vaccine ,Multidisciplinary ,biology ,Vaccination ,Middle Aged ,Tos ,Hospitalization ,Child, Preschool ,Female ,medicine.symptom ,medicine.drug ,Research Article ,Adult ,medicine.medical_specialty ,Catalonia ,Adolescent ,Navarra ,Young Adult ,Navarre ,medicine ,Humans ,Tos ferina ,Whooping cough ,Aged ,Cyanosis ,Malalts hospitalitzats ,business.industry ,lcsh:R ,Infant, Newborn ,Infant ,Catalunya ,biology.organism_classification ,medicine.disease ,Infant newborn ,Confidence interval ,Cough ,Spain ,Pertussis vaccine ,lcsh:Q ,business - Abstract
Pertussis causes a large number of cases and hospitalizations in Catalonia and Navarra. We made a study of household cases of pertussis during 2012 and 2013 in order to identify risk factors for hospitalization in pertussis cases. Each primary case reported triggered the study of their contacts. Close contacts at home and people who were in contact for >2 hours during the transmission period of cases were included. The adjusted OR and 95% confidence intervals (CI) was calculated using logistic regression. A total of 1124 pertussis cases were detected, of which 14.9% were hospitalized. Inspiratory whoop (aOR: 1.64; CI: 1.02–2.65), apnoea (aOR: 2.47; CI: 1.51–4.03) and cyanosis (aOR: 15.51; CI: 1.87–128.09) were more common in hospitalized than in outpatient cases. Hospitalization occurred in 8.7% of correctly-vaccinated cases, 41.1% of non-vaccinated cases and 9.4% of partially-vaccinated cases. In conclusion, inspiratory whoop, apnoea and cyanosis were associated factors to hospitalization while vaccination reduced hospitalizations due to pertussis. Ministry of Science and Innovation, Institute of Health Carlos III (Project PI11/02557) and Fondo Europeo de Desarrollo Regional (FEDER-Una manera de hacer Europa); the Catalan Agency for the Management of Grants for University Research (AGAUR Grant number 2014/ SGR 1403).
281. Epidemiology of pertussis in two Ibero-American countries with different vaccination policies: lessons derived from different surveillance systems
- Author
-
Joan A. Caylà, Josefa Masa-Calles, Altagracia Brache, Sandy L. Santiago, Patricia Grullón, Rubén Solano, Zacarias Garib, Angela Domínguez, Universitat de Barcelona, and Instituto de Salud Carlos III
- Subjects
Male ,Bordetella pertussis ,Pediatrics ,Epidemiology ,Child Health Services ,0302 clinical medicine ,Ethnicity ,030212 general & internal medicine ,Vacunació ,Child ,Pertussis Vaccine ,education.field_of_study ,Surveillance ,biology ,Incidence (epidemiology) ,lcsh:Public aspects of medicine ,Incidence ,Vaccination ,Child, Preschool ,Population Surveillance ,Female ,Research Article ,Infectious disease epidemiology ,medicine.medical_specialty ,Adolescent ,República Dominicana ,Population ,03 medical and health sciences ,030225 pediatrics ,medicine ,Humans ,Tos ferina ,Espanya ,education ,Epidemiologia ,Whooping cough ,business.industry ,Immunization Programs ,Public health ,Dominican Republic ,Public Health, Environmental and Occupational Health ,Infant ,lcsh:RA1-1270 ,Mandatory Reporting ,biology.organism_classification ,medicine.disease ,Infant mortality ,Spain ,business ,Demography - Abstract
BACKGROUND: Pertussis is a re-emerging disease worldwide despite its high vaccination coverage. European and Latin-American countries have used different surveillance and vaccination policies against pertussis. We compared the epidemiology of this disease in two Ibero-American countries with different vaccination and surveillance policies. METHODS: We compared the epidemiology of pertussis in Spain and the Dominican Republic (DR). We present a 10-year observational study of reported pertussis based on suspected and/or probable cases of pertussis identified by the national mandatory reporting system in both countries between 2005 and 2014. Both countries have a similar case definition for pertussis surveillance, although Spain applies laboratory testing, and uses real time PCR and/or culture for case confirmation while in DR only probable and/or suspected cases are reported. We analyzed incidence, hospitalization, case-fatality rates, mortality and vaccination coverage. RESULTS: The average annual incidence in children aged
282. Inhibition of PCR-based assay for Bordetella pertussis by using calcium alginate fiber and aluminum shaft components of a nasopharyngeal swab
- Author
-
Stanley States, Garth D. Ehrlich, Robert M. Wadowsky, Therese Libert, and Stella Laus
- Subjects
Microbiology (medical) ,DNA, Bacterial ,Bordetella pertussis ,Calcium alginate ,Alginates ,Whooping Cough ,Molecular Sequence Data ,Polymerase Chain Reaction ,Microbiology ,chemistry.chemical_compound ,Glucuronic Acid ,Nasopharynx ,Humans ,Fiber ,Bacteriological Techniques ,biology ,Base Sequence ,Polyethylene Terephthalates ,Hexuronic Acids ,biology.organism_classification ,chemistry ,Tos ferina ,DNA Probes ,Bacteria ,Aluminum ,Research Article - Abstract
A PCR-based assay for Bordetella pertussis was inhibited by using a calcium alginate fiber-tipped swab with an aluminum shaft but not by using a Dacron fiber-tipped swab with a plastic shaft. The calcium alginate fiber component inhibited the assay following storage for less than 1 min in a suspension of 10(3) CFU of B. pertussis per ml, whereas the aluminum shaft component required storage for at least 48 h in order to cause inhibition. We recommend the Dacron swab over the calcium alginate swab for collecting specimens for testing in PCR-based assays.
283. From whom do children catch pertussis?
- Author
-
Mark G. Thomas and H P Lambert
- Subjects
Adult ,Bordetella pertussis ,Pediatrics ,medicine.medical_specialty ,Adolescent ,biology ,Whooping Cough ,business.industry ,General Engineering ,Infant ,General Medicine ,biology.organism_classification ,medicine.disease ,Child, Preschool ,medicine ,Humans ,General Earth and Planetary Sciences ,Child ,Tos ferina ,business ,Whooping cough ,Research Article ,General Environmental Science - Abstract
Enquete sur 26 familles (90 personnes au total) dans lesquelles 1 enfant au moins a ete atteint de coqueluche. La contamination se fait frequemment par un des parents atteint soit de coqueluche typique, soit de coqueluche atypique, soit d'infection asymptomatique par Bordetella pertussis
- Published
- 1987
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