301. Biomarkers of Toxic Exposure and Oxidative Stress Among U.S. Adult Users of Premium Cigar Versus Other Cigar Subtypes: 2013–2019
- Author
-
Dai, Hongying Daisy, Benowitz, Neal L, Rogan, Eleanor, Degarege, Abraham, Buckley, James, and Khan, Ali S
- Subjects
Epidemiology ,Public Health ,Health Sciences ,Prevention ,Tobacco Smoke and Health ,Tobacco ,Substance Misuse ,Aetiology ,2.2 Factors relating to the physical environment ,Cancer ,Good Health and Well Being ,Adult ,Humans ,Nicotine ,Smoking ,Tobacco Products ,Nicotiana ,Biomarkers ,Nitrosamines ,Oxidative Stress ,Clinical Sciences ,Public Health and Health Services ,Marketing ,Public health - Abstract
IntroductionCigars are currently the second-highest-used combustible tobacco product among U.S. adults, but knowledge about health effects of premium cigars versus other cigar subtype use is limited.Aims and methodsThis study analyzed the biospecimen data (n = 31 875) from Waves 1-5 of the Population Assessment of Tobacco and Health Study, collected during 2013-2019. Multivariable generalized estimation equations, accounting for within-person clustering, were conducted to examine differences in urine biomarkers of exposure (BOE) from five classes of harmful and potentially harmful constituents along with a biomarker of oxidative stress (urine 8-isoprostane) among exclusive users of premium cigars versus other exclusive cigar subtypes (ie, non-premium large cigars, cigarillos, and filtered cigars), cigarettes, and non-tobacco users.ResultsIn comparison to non-tobacco users, exclusive premium cigar users had higher geometric mean concentrations of the nicotine metabolite cotinine (5.8 vs. 0.5ng/mg, p more...
- Published
- 2023