201. Structure and function of mammalian cilia
- Author
-
Søren T. Christensen and Peter Satir
- Subjects
Cell signaling ,Histology ,Cell division ,Motility ,Review ,Biology ,Primary cilia ,Intraflagellar transport ,Cell Movement ,Animals ,Humans ,Cilia ,Molecular Biology ,Motile cilia ,Cilium ,Cell Biology ,Signaling ,Ciliopathies ,Cell biology ,Medical Laboratory Technology ,Sensory organelles ,Motile cilium ,Ciliary Motility Disorders ,Developmental biology - Abstract
In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. This view has had unanticipated consequences for our understanding of developmental processes and human disease.
- Published
- 2008