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Objective: In some studies, it has been shown that the concept of office hours (OH) and out-of-office hours (OFH) at intensive care unit (ICU) admission has an effect on ICU mortality. In this study, we aimed to examine the effect of this concept on ICU mortality in a medical ICU (MICU). Material and Method: After retrospectively examining the general characteristics of the patients hospitalized in Gazi University Hospital MICU between January 1, 2017 and December 31, 2018, patients were divided into two groups as admitted ICU in OH (Monday-Friday; 08.00 am to 04.59 pm) or in OFH (Monday-Friday; 05.00 pm to 07.59 am, weekends, and all public holidays). These two groups were then compared in terms of patient characteristics and ICU mortality. Results: Five hundred and twenty seven patients were included in the study. 238 of these patients were admitted to MICU in OH and 289 of them in OFH. The median age of the patients was 70 (57-79) years, 52% of them were male. There was no difference between the patients admitted ICU in OH and OFH in terms of age, gender, acute illness severity scores, reasons for hospitalization, length of ICU stay, interventions and treatments in the ICU. Patients admitted to ICU in OFH had higher organ failure scores (SOFA score) (p =0.026). In terms of comorbidities, there was a difference between those admitted to ICU in OH and those admitted to ICU in OFH. More acute kidney injury (AKI) developed during their ICU stay in patients admitted to ICU in OFH. A total of 212 patients (40.23%) died during ICU hospitalization. Of these, 131 (61.79%) were admitted to ICU in OFH, 81 (38.21%) were admitted to ICU in OH and this difference was statistically significant (p =0.008). Conclusion: In this study, admission to ICU in OFH increased the ICU mortality. Having higher organ failure scores and different comorbidities in patients admitted to ICU in OFH were found to be the factors explaining this mortality difference. New studies with broad participation are needed to verify this result and explain its reasons. [ABSTRACT FROM AUTHOR]

Background: It was aimed to investigate the effects of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and mean platelet volume (MPV) on mortality in cases of acute type A aortic dissection in this study. Materials and Methods: The files of patients who were operated on with the diagnosis of acute type A aortic dissection in Adıyaman Training and Research Hospital between January 2013 and November 2020 were reviewed retrospectively. The patients were divided into those who were discharged (Group I) and those who resulted in death (Group II). Demographic data, preoperative blood tests, operation times and mortality status of the patients were recorded. MPV, NLR and PLR were calculated and recorded in blood samples taken preoperatively. The obtained data were compared between groups and the relationship of the data with mortality was examined. Results: 23 of the patients in the study were male and 9 were female. While 22 of the patients were discharged with cure, 10 patients resulted in mortality. A significant difference was found in the exit group in terms of EF, CRP and cardiopulmonary bypass times (p<0.05). MPV, NLR and PLR were found to be higher in patients who resulted in death. However, this difference was not statistically significant (p>0.05). Conclusions: MPV, NLR and PLR could not be shown to have an effect on predicting mortality in acute type A aortic dissection. [ABSTRACT FROM AUTHOR]

Aim: Liver dysfunction is an early finding caused by the inflammation and hypoperfusion developed in sepsis. Magnesium deficiency may contribute to an excessive response to immune stress and inflammatory tissue damage in sepsis. This study aimed to evaluate the relationship between serum magnesium levels and early liver dysfunction (ELD) in patients with sepsis. Material and Methods: 142 patients who developed sepsis were divided into two groups according to their liver function, as sequential organ failure assessment (SOFA) hepatic subscore <2 (Non-ELD, n=72) and SOFA hepatic subscore ≥22 (ELD, n=70). The disease severity, including the acute physiology and chronic health evaluation (APACHE) II score and the SOFA score, biochemical determination, and microbiological cultures were evaluated. Results: ELD patients presented APACHE II and total SOFA scores higher than Non-ELD patients, while PaO2/FiO2 ratios were significantly lower (both p<0.001). Hypomagnesemia and hypoalbuminemia were independently associated with ELD (OR: 6.55, 95% CI: 2.62-16.36, and OR: 4.62, 95% CI: 1.35-15.84, respectively). To predict ELD, the area under the curve was 0.81 (95% CI: 0.74-0.89, p<0.001) and 0.70 (95% CI, 0.61-0.79; p<0.001) for serum magnesium and albumin, respectively. The mortality rate in all septic patients was 35.0% for hypomagnesemia and 25.6% for normomagnesemia (p=0.065). The mortality rate in ELD patients was 34.1% for hypomagnesemia and 30.7% for normomagnesemia (p=0.415). Conclusion: The reduction of magnesium levels was associated with increased rates of ELD in critically ill patients with sepsis. Admission hypomagnesemia did not adversely affect mortality neither in all sepsis patients nor in those who developed ELD. [ABSTRACT FROM AUTHOR]

Aim: Coronavirus disease 2019 (COVID-19) mostly proceeds with mild respiratory symptoms, but sometimes severe pneumonia, cytokine storm, and acute respiratory distress syndrome can develop. Anti-cytokine treatments are being tried for cytokine storm. In this study, we aimed to examine the effect of tocilizumab on mortality associated with COVID-19. Material and Methods: The study included 146 patients with moderate-to-severe acute respiratory distress syndrome diagnosed with COVID-19. The patients were divided into two groups, receiving only standard treatment (ST group, n=44), and tocilizumab treatment in addition to standard treatment (TCZ group, n=102). Groups were compared in terms of demographic, clinic, and laboratory data. Also, mortality rates were determined to detect the effect of tocilizumab on mortality. Results: Overall, 36.3% (n=53) of the patients were female, 63.7% (n=93) were male, and the mean age was 69.5±14.2 years. The mortality rate was 29.4% (n=30) in the TCZ group and 52.3% (n=23) in the ST group (p=0.009). While C-reactive protein, fibrinogen, and lactate levels on admission to the intensive care unit (ICU) were similar across the groups, the TCZ group had higher ferritin levels (p=0.006). On discharge from ICU, the TCZ group had a significant decrease in C-reactive protein (p<0.001), while their ferritin levels decreased to levels in the ST group (p=0.134). The absence of tocilizumab in the treatment regimen was associated with a 2.63-fold increase in the mortality risk. Conclusion: Tocilizumab reduces the mortality in COVID-19 patients in ICU. However, further studies are warranted to better elucidate the efficacy and side effects of tocilizumab. [ABSTRACT FROM AUTHOR]

Aim: Anemia is associated with increased mortality and morbidity in all patients undergoing surgery. This study aimed to reveal to what extent anemia caused postoperative complications before hiatal hernia surgery. Material and Methods: One hundred and ninety-two patients operated for hiatal hernia in our clinic between 2015 and 2019 were analyzed retrospectively. Patients were compared according to demographics, preoperative laboratory values, preoperative Charlson comorbidity index score, hiatal hernia type, postoperative intensive care requirement, presence of postoperative complications, Clavien-Dindo score, blood transfusion need, and length of hospital stay. Results: Of the patients, 109 were female and 83 were male. The mean age was 50.1±9.1 years. Fifty-four (28.2%) of the patients were in the anemic group, and 138 (71.8%) were in the non-anemic group. There was no statistically significant difference between the groups in terms of gender distribution (p=0.663). When the groups were compared in terms of age distribution, it was found that the anemic group was older than the non-anemic group and the difference was statistically significant (p<0.001). There was a significant difference between the groups in terms of the postoperative complications rate and it was more common in the anemic group (p<0.001). There was a significant difference between the groups in terms of the need for intensive care and blood transfusion in the postoperative period (p=0.020, p<0.001, respectively). Conclusion: Preoperative anemia increases postoperative complications in hiatal hernia surgery. Therefore, the presence of anemia should be investigated before hiatal hernia surgery and patients with anemia should be followed up closely postoperatively. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mersin Üniversitesi sağlık Bilimleri Dergisi is the property of Mersin University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Anatolian Clinic Journal of Medical Sciences is the property of Hayat Saglik ve Sosyal Hizmetler Vakfi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ege Journal of Medicine is the property of Ege University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: This study aims to identify the association of cardiac Troponin T (cTnT) levels with hospitalization and in-hospital mortality in patients admitted to the emergency department (ED) and diagnosed with COVID-19. Material and Method: Retrospectively, we scanned the data of adult patients presenting to the ED of a university hospital within 50 days of the first COVID-19 case admission (March 2020 - May 2020). The study group consisted of patients diagnosed with COVID-19 by reverse-transcriptase polymerase chain reaction, and had cTnT test. Demographic and laboratory data, thoracic computed tomography (CT) imaging findings, and length of hospital stay were also collected. The study outcomes were patients' hospitalization status and in-hospital mortality. Results: Out of 36 patients, 9 (25%) were discharged, 20 (55.6%) remained in-patients in the ward, and 7 (19.4%) in the intensive care unit. When overall in-patients were compared to discharged patients, a significant difference was observed with regard to age [median (25% -75%)] [60 (45-69) to 28 (26-39.5) years, respectively; p=0.003)], thoracic CT score [6 (0-11) to 0 (0-0.5), respectively; p=0.005], admission cTnT values [5.99 (3.50-15.55) to 3 (3-3.28) ng/L; p=0.012]. The mortality rate among in-patients was 18.5%. In the multivariate cox regression model, none of these parameters significantly affected survival. Conclusion: The cTnT values of COVID-19 patients are likely to be associated with hospitalization and mortality. Thoracic CT score was higher in patients admitted to the intensive care unit. However, neither cTnT values nor thoracic CT scores have a statistically significant effect on survival, even if their distributions are different between survived and non-survived groups. [ABSTRACT FROM AUTHOR]

Introduction: Umbilical cord blood gas values at birth are the best method to show the acid-base balance of the newborn. While gas values in term and late preterm infants provide information about the clinical results of the newborn, the use of these values in premature infants is not clear. In this study, it was aimed to evaluate the relationship between umbilical cord blood gas values and mortality in preterm babies born at <29 weeks of gestation. Materials and Methods: Babies with a gestational age of <29 weeks were included in the study. Our study was carried out retrospectively. Umbilical cord gas (pH: power of hydrogen, pCO2: partial pressure of carbon dioxide, HCO3: bicarbonate, BE: base excess) values, demographic characteristics and clinical results were compared in the groups with and without mortality in the patients included in the study. Results: A total of 346 patients were included in the study, with 54 patients with mortality and 292 patients without mortality. According to our results, the mortality rate was 15.6% (54/346) in preterms with <29 weeks of gestation. Gestational week and birth weight were found to be lower in the group with mortality compared to the group without mortality (p<0.001, p<0.001, respectively). pH, HCO3 and BE were lower in patients with mortality compared to patients without mortality (p<0.001, p<0.001, p<0.001, respectively). Results were similar between the groups in terms of pCO2 values (p=0.270). Threshold pH value for mortality ≤7.18 [area under curve (AUC): 0.627], threshold HCO3 value ≤19.3 mmol/L (AUC: 0.950), and threshold BE value ≤-8.1 mmol/L (AUC: 0.969) was detected. Conclusion: HCO3 and BE are the most valuable parameters for mortality in umbilical cord blood gas in premature babies born with a gestational week <29. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Tepecik Education & Research Hospital / İzmir Tepecik Eğitim ve Araştırma Hastanesi Dergisi is the property of Logos Medical Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Tepecik Education & Research Hospital / İzmir Tepecik Eğitim ve Araştırma Hastanesi Dergisi is the property of Logos Medical Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Tepecik Education & Research Hospital / İzmir Tepecik Eğitim ve Araştırma Hastanesi Dergisi is the property of Logos Medical Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Eurasian Journal of Toxicology is the property of Eurasian Journal of Toxicology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: ST-elevation and depression in augmented voltage right (aVR) are associated with high mortality and prolonged coronary artery disease in patients with the acute coronary syndrome. It was aimed to compare the patients in terms of cardiac troponin, threevessel disease, serum osmolarity and mortality. Methods: The study was performed through retrospective scanning of the files of 372 (162 females, mean age 64±10 years) patients who were admitted to the emergency department due to chest pain between January 2014 and December 2016 and who were admitted to the cardiology clinic with the diagnosis of the acute coronary syndrome. Patients with ST-elevation in aVR were included in Group I and patients with ST-depression in aVR were included in Group II. Results: Osmolarity was 295.8±16 in Group I and 291.7±8.1 in Group II. Troponin values in Group I was higher than Group II (p=0.002). The Gensini score was 40±2.7 in Group I and 28.6±2.3 in Group II (p=0.001). In Group I, unstable angina was found in 32 (18.1%) patient, ST-elevated myocardial infarction (MI) in 135 (76.3%) and non-ST-elevated MI in 10 (5.6%), whereas these numbers and percentages were 62 (31.8%), 106 (54.4%) and 27 (13.8%) in Group II, respectively (p=0.001). The three-vessel disease was found in 56 (31.6%) patients in Group I and 29 (14.9%) patients in Group II (p=0.001). The most common complication in both groups was ischemic heart failure. Mortality was observed in 36 (20.3%) patients in Group I and 14 (7.2%) in Group II. Osmolarity was lowest in unstable angina, highest in non-ST-elevation MI, and was also higher in three-vessel disease, men, and patients with mortality. Conclusion: In patients with acute coronary syndrome, osmolarity may predict ST-elevation and depression in aVR, three-vessel disease, and mortality. [ABSTRACT FROM AUTHOR]

Objective: We aimed to investigate the diagnostic accuracy of 64-multidetector coronary computed tomographic angiography (CCTA) for stable symptomatic patients and evaluate the relationship between severity of coronary artery disease (CAD), cardiovascular risk scores, and coronary artery calcium (CAC) scores. We also assessed the possible predictors of all-cause mortality at a median of 10 years of follow-up. Materials and Methods: This retrospective, observational study included 45 patients with suspected CAD who had undergone CCTA and invasive coronary angiography within the previous two weeks (67% male, mean age 62.1±10.72 years). Using CCTA, sensitivity, specificity, and positive and negative predictive values (PPV and NPV) were calculated on a segment and patient basis analysis. The total CAC (Agatston units [AU]) and systematic coronary risk evaluation (SCORE) scores were calculated for each patient. Results: The CCTA NPV and PPV for the segment- and patient- based analyses were 97% and 100%, and 94% and 88%, respectively. CAC scores >100 AU reflected a higher incidence of significant CAD (OR=4.88, 95% CI 1.62–14.68 p<0.001), and CAC scores were significantly correlated with SCORE risk values (r=0.669, p<0.001). Ultimately, 6 patients (13.3%) died. Combined CAC and SCORE value and age significantly improved the prediction of all-cause mortality at a median of 10 years of follow-up (AUC=0.833, 95% CI 0.693–0.974, p=0.009). Conclusion: 64-multidetector CCTA has high diagnostic accuracy for detecting or excluding significant CAD. Moreover, CAC and SCORE risk score may provide valuable prognostic information for predicting long-term mortality and improving preventive therapies. [ABSTRACT FROM AUTHOR]

Aim: The aim of this study is to examine whether the timing of surgery in our elderly patients with a diagnosis of hip fracture changed before and after the pandemic, and whether this situation caused an increase in mortality. Patients and Methods: The patients who were operated with the diagnosis of hip fracture between March 2019 and March 2020 in our hospital database were accepted as in the pre-pandemic period, and the patients who were operated with the diagnosis of hip fracture between April 2020 and April 2021 were considered as in pandemic period. Both groups were statistically compared in terms of age, gender, waiting time for surgery, length of hospital stay and one year mortality. Results: When the factors affecting mortality were examined, the time elapsed until surgery significantly increased mortality. While the mean waiting time for surgery was 27.6±19.4 hours in all patients, it was 25.7±19.1 hours in Group 1 and 29.6±19.6 hours in Group 2 and there was a significant difference between the two groups (p=0.043). The cut-off value of the waiting time for surgery, which caused mortality, was determined as "23.35" hours. While no significant increase in mortality was found in Group 1 (p=0.340), the increased delay for surgery in Group 2 affected mortality significantly (p=0.027). Conclusion: In this study, it was found that the increase in the delay of admission for surgery over 23.35 hours in the elderly population after hip fractures was directly associated with one year of mortality and also we think that the waiting time for surgery in the pandemic conditions is one of the factors that negatively affect mortality in these patients. [ABSTRACT FROM AUTHOR]

Purpose: There are not enough studies evaluating the change in electrolytes and hormones in patients with sepsis. The aim of our study is to evaluate the relationship between the changes in serum calcium (Ca), magnesium (Mg), phosphorus (P), 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) levels and mortality in patients with sepsis. Materials and Methods: Our study was conducted on patients with sepsis who were hospitalized in the intensive care unit (ICU) between October 2017 and January 2019. The levels of Ca, Mg, P, 25(OH)D and PTH, together with demographic and clinical characteristics of non-survivor and survivor patients, were compared. Results: A total of 225 patients were enrolled into the study. Of the 225 patients, 94 patients (41.2%) died and 131 patients (58.8%) were discharged. PTH and P levels were found to be significantly higher, and 25(OH)D, Ca, and Mg levels were significantly lower in non-survivor patients than in survivor patients. Conclusions: During sepsis, the change in Ca metabolism which is in a delicate balance, in the direction of hypocalcemia, hypomagnesemia, hyperphosphatemia, low 25(OH)D and high PTH were found to be associated with mortality. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study is to investigate the power of disease severity scores to predict the development of Severe Acute Pancreatitis (SAP) and mortality in the early period over 65 years old diagnosed with acute pancreatitis in the emergency department. Materials and Methods: We calculated RANSON (on admission) and Computed Tomography Severity Index (CTSI) in addition to Bedside Index for Severity in Acute Pancreatitis (BISAP) score on admission to the emergency department. Results: One hundred and sixty patients (46.9% over 80 years of age) were included in the study. We observed statistically higher length of hospitalization, longer duration of stay in the intensive care unit, SAP and higher mortality in patients over 80 years of age. When we examined the ROC curve, we determined that the AUC values of the BISAP score were highest in both SAP and mortality estimation (AUC: 0.911, 95% CI 0.861-0.962; AUC: 0.918, 95% CI 0.864-0.9722, respectively). Binary logistic analysis indicated a 4.7-fold increased risk for SAP and a 12.3-fold increased mortality for each unit increase in BISAP score value. Conclusion: BISAP may be a good predictor for SAP and mortality estimation on admission to the emergency department in patients over 65 years of age with acute pancreatitis. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Van Tip Dergisi is the property of Yuzuncu Yil University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkiye Klinikleri Archives of Lung is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The ‘top of the basilar syndrome’ (TOBS) may occur when an embolus impacts in the distal basilar artery. We aimed to investigate the relationship between the clinical, radiological parameters of TOBS, its prognosis, and mortality rates, in Xxxxxxx, Turkey. Materials and Methods: Age, sex, presenting symptoms, National Institutes of Health Stroke Scores (NIHSS), infratentorial infarct volume (IIV), supratentorial infarct volume (SIV) lenght of stay (LOS) in neurology clinic and intensive care unit (ICU), the duration of mechanical ventilation (MV) and mortality were recorded. Results: Thirty-one patients (18 female,13 male) with diagnosed TOBS were included. The frequency was 2.2% among 1379 patients within 2,5years. The mean age was 69.0±12.1years. According to NIHSS, 11 (35.5%) patients had mild stroke, 16 (51.6%) moderate, and 4 (12.9%) severe stroke. The mean IIV was 8.84±10.44mm3 (0.17-33.88), SIV was 15.11±22.32mm3 (0.11-87.91). The average LOS in neurology clinic was 6.0±3.6, in ICU was 40.8±40.3days. Twenty-one (67.7%) patients needed to be in an ICU. Patients admitted to the ICU had significantly higher decreased level of consciousness (DLC) and visual abnormalities, NIHSS, IIV.(p0.05) 13/21 patients admitted to the ICU required MV. The mean duration of MV was 33.8±45.3days. DLC, ataxia, visual abnormalities as an initial symptoms, NIHSS, IIV were higher among patients who required MV compared with who did not. The mortality rate was 32.3%. NIHSS, LOS in clinic and ICU, the duration of MV of patients who died were statistically higher.(p0.05) Conclusions: It is important to determine effective parameters in order to prognose TOBS which is a rare stroke syndrome.

Abstract Background : Acute mesenteric ischemia (AMI) is a life-threatening pathology that often requires urgent surgical intervention. It is frequently faced in elderly patients. Despite advances in the diagnosis of AMI morbidity, and mortality rates are still high. The presence of comorbidities delayed surgical intervention due to diagnostic difficulties, and in most cases, older patients with heart problems may be remarkable factors for higher mortality rates. Diagnostic challenges are tried to be overcome with both imaging methods and laboratory findings. Unfortunately, to date, no clear laboratory parameters have been described in diagnosing or predicting mortality of mesenteric ischemia. Materials and Methods : The patients diagnosed with acute arterial mesenteric ischemia between the dates 2010-2019 were enrolled in the study. Demographic characteristics, diagnostic biochemical parameters (lymphocyte, neutrophil, albumin, C-reactive protein, lactate, lactate dehydrogenase, Di-Dimer, troponin, white blood count, platelet, fibrinogen, creatine kinase-MB) levels, as well as comorbidities of the patients, were evaluated. Results : A total of 149 patients was enrolled in the study, with a mean age of 66.11 . In the non-survivor group, neutrophil, RDW, lactate, DDM, Fibrinogen, and CK-MB levels, furthermore albumin levels were defined as significantly elevated in the survivor group (p0.05). Hypertension was the major comorbidity by far in both groups. Conclusion : High levels of fibrinogen, lactate, DDM, CK-MB levels and low levels of albumin levels may be predictors of mortality in mesenteric ischemia.

Objective: This study aimed to evaluate the clinical presentations, outcomes, and changes over 8 years period of infective endocarditis (IE) patients in a tertiary hospital in Turkey and to identify predictors of mortality. Materials and Methods: All adult patients who were hospitalized with a diagnosis of definite IE were included in the study. The data were analyzed both collectively and separately in two consecutive four-year periods i.e. 2010-2013 and 2014-2017. Results: There were 72 IE cases in the study. Male/female ratio was 1.57:1 (44 males,28 females). The mean age of the patients was 48.5±17.6 years. Staphylococci were the most common agents (44%). Independent predictors of mortality were heart failure, the invasive procedure before IE, and lower platelet level. Increased invasive procedures before IE and enterococcal endocarditis were found significantly to be higher during the last period (2014-2017). Conclusions: IE is still a serious and deadly disease in the 21st century. Our data indicate that invasive procedures have been increasing before IE and this increase with associated poor prognosis.

Purpose: The aim of this study was to evaluate the general clinical characteristics of acute gastrointestinal system (GIS) bleeding patients who were followed-up in the intensive care unit (ICU) and the risk factors for mortality. Materials and Methods: The GIS bleeding patients followed up in a medical ICU between October 2016 and March 2019 were included. Patients were evaluated for demographic, clinical and laboratory data (on admission and after 24-hours) and compared according to the mortality status (surviving vs. non-surviving). Results: A total of 64 patients (37 males and 27 females) with a median age of 73.5 (31-93) years were evaluated. All patients had upper GIS bleeding and the mortality rate was 29.7%. There was no difference between the mortality groups for gender, age and chronic co-morbid diseases except malignancy. High BUN, creatinine, INR, and lactate levels after 24 hours were significantly associated with mortality. All patients had a diagnosis of upper GIS bleeding. In the logistic regression analysis, the presence of acute respiratory insufficiency, long hospital stays before ICU, high SOFA score and high lactate levels after 24 hours were the independent predictors of ICU mortality). Conclusion: In this study, we found that high levels of BUN, creatinine, INR, and lactate levels in the first 24 hours of follow-up, rather than the values on admission to ICU, were associated with increased mortality. Therefore, we suggest that close monitoring and rapid normalization of these values with appropriate treatments is important.

Amaç: Sars-Corona Virüsü (SARS-CoV-2), 2019 yılının aralık ayında ilk kez Çin’de görülen ve şiddetli akut solunum yetmezliğine neden olan bir korona virüstür. Diyabet tüm dünyada morbidite ve mortalitenin önemli sebeplerinden biri olmakla beraber diyabetik hastalarda koronavirüs enfeksiyonun morbidite ve mortalitenin daha yüksek olduğu saptanmaktadır. Biz bu çalışmamızda İç hastalıkları kliniğinde koronovirüs enfeksiyonu ve koronavirüs enfeksiyonu şüphesi ile takip edilen diyabetik hastalarda Hba1c, kan şekeri profilinin morbidite ve mortalite üzerine etkisinin retrospektif olarak analizinin yapılmasını amaçladık. Gereç ve Yöntem: İç hastalıkları kliniğinde 15/03/20 ile 01/07/20 tarihleri arasında SARS-CoV-2 enfeksiyonu nedeniyle takip edilen diyabetik hastalar çalışmaya dahil edildi. Hasta dosyaları taranarak anamnez, labaratuvar, tedavi ve prognoz oluşturulan formalra kaydedildi. Diyabetik hastalardaki koronavirüs enfeksiyonlarında hastanın Hba1c, kan şekeri profili ve lipid profilinin yoğun bakım ihtiyacı için risk faktörü olarak kullanılmasının ek bir fayda getirip getirmediği istatistiksel yöntemlerle analiz edildi. Bulgular: Hastanemiz dahiliye kliniğinde Covid-19 enfeksiyonu nedeniyle yatan daha önce diyabet tanısı alan oral antidiyabetik ve/veya insulin kullanan toplam 31 hasta retrospektif olarak incelenmiş olup hastaların demografik özellikleri Tablo-1 de belirtilmiştir. 31 hastanın tamamı boğaz ağrısı, öksürük, ateş ve nefes darlığı gibi tipik bulgular ile hastaneye başvurdu. Hastaların tamamına BT çekildi ve nasofarnegeal ve orofarengeal PCR alındı. PCR testi pozitif saptanan 18 hasta (%58.1) ve Tipik BT tutulumu olan 30 hasta (%96.8) saptandı. Covid-19 nedenli takip edilen diyabeti olan 31 hastanın 17 sinde; hipoksi, takipne ve hipotansiyon gibi sebepler ile yoğun bakım ihtiyacı gelişti. Yoğun bakım ihtiyacı olan 17 hastanın 10’u mortal seyretti. Açlık kan şekeri yüksekliği ile yoğun bakım ihtiyacı ve mortalite arasında anlamlı ilişki saptandı. HbA1C ve lipit profili ile yoğun bakım ihtiyacı arasında anlamlı ilşki yoktu. Mortal grupta LDL ve total kolesterol anlamlı düzeyde düşük tespit edildi. Sonuç: Diyabetik hasta grubunda kötü glisemik kontrol ve lipit parametreleri prognostik faktör olarak dikkate alınmalıdır.

Purpose: In the present study, the possibility of predicting mortality with the change in coagulation parameters depending on the severity of Covid-19-associated pneumonia was investigated. Materials and Methods: A total of 137 patients with Covid-19-associated pneumonia were included in the study. The patients were divided into three groups according to the severity of pneumonia as mild, moderate and severe. According to the severity of pneumonia, the parameters of complete blood count and the levels of biochemical parameters were compared between the groups. By examining blood parameters according to mortality, ROC analysis and regression analysis were performed to determine the net effect of these parameters on mortality. Results: As the severity of pneumonia increased, Prothrombin time (PT), International normalized ratio (INR) and Activated partial thromboplastin time (aPTT) values were also increased, and a statistically significant difference was found between the groups in PT and INR values. PT, INR and aPTT levels were higher in cases with mortality. Mortality can be predicted with 93.5% sensitivity and 97.5% specificity. according to the >45.1 seconds(sec) cut-off value of the coagulation parameter (aPTT+PT. Conclusion: The coagulation parameter (aPTT + PT), whose level increases secondarily to the increase in Covid-19-associated pneumonia severity, provides successful results in predicting mortality, and may be a parameter that we can recommend in clinical use.

Purpose: The aim of our study is to investigate the prognostic value of Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) in determining mortality in patients hospitalized for intensive care unit (ICU) sepsis. Materials and Methods: This study retrospectively evaluates all patients hospitalized with sepsis in our ICU between February 2017 and April 2018. In addition to the demographic and clinical characteristics of the patients, complete blood count parameters were also recorded. Demographic and clinical characteristics, mainly NLR, MLR and PLR results, and other laboratory results of patients with sepsis were compared between the ones with and without mortality. Results: Four hundred and eleven patients were included in the study. 55.7% (229/411) of patients with sepsis died and 44.3% (182/411) were discharged alive. NLR, MLR and PLR were higher in the group with mortality compared to the survivor group. The cut-off value for predicting mortality in patients with sepsis was 9.2 for NLR, ≥0.8 for MLR, and ≥187.3 for PLR. The area under the curve (AUC) value for NLR was 0.825, the AUC value for MLR 0.835 and the AUC value for PLR was 0.720. Conclusion: High NLR, MLR and PLR values are associated with mortality in sepsis patients hospitalized in ICU, and the most significant parameter for mortality indicator among the three rates was found to be MLR with the highest AUC value.

Objective: Early repolarization (ER) is a common finding in cases. It can be benign or malignant. We aimed to evaluate the effects of early repolarization morphology and electrocardiogram (ECG) findings on the clinic, prognosis, and mortality with angiography findings. Methods: This retrospective study included 442 patients who were admitted to the emergency department between January 2010 and December 2015 and had ER in their ECG. The patients were divided into two groups according to the horizontal and ascending ER morphology. According to the derivation, four groups were formed as inferior, inferolateral, anterior, and common. During the five-year follow-up period, patients who had an indication for angiography due to chest pain and underwent the procedure were divided into four groups (left anterior descending (LAD), circumflex (Cx), right coronary artery (RCA), and normal) according to the vessel in which the lesion was detected in angiography. Results: The average age of the patients in the study was 52.16±9.07 years and 260(58.8%) were male. Horizontal morphology was observed in 123(28%) of the patients and ascending morphology in 319(72%). Mortality was detected in 9(7.3%) of the horizontal group and 6(1.9%) of the ascending group (p=0.008). In the angiography results of the mortality group, 8(53.3%) patients had Cx, 4(26.7%) patients had RCA, and 3(20%) patients had LAD occlusion. Angiography results of 318(74.5%) surviving patients were normal (p=0.001). Mortality; It had a strong positive correlation with family history, Brugada Syndrome, aVR ST-segment formation and the presence of syncope, and moderate positive correlation with gender, notch presence, QRS morphology in V1-2, and angiography results. Conclusions: Early repolarization morphology may be a helpful finding for prognosis, mortality, and interventional angiography decisions. [ABSTRACT FROM AUTHOR]

Objective: In our study, we aimed to determine the factors associated with poor outcome by evaluating the data of possible/definite Coronavirus 2019 (COVID-19) cases coming to the emergency department in two centers and to establish a risk scoring system. Methods: This study has been designed as a retrospective study performed on COVID-19 cases. Patients’ sociodemographic data, complaints, vital signs, laboratory parameters, service/ intensive care admission status, and the presence of death were analyzed. Results: A total of 436 patients were included in the study. We divided the cases into two groups in terms of poor outcome. The factors associated with poor outcome such as the presence of comorbid disease (p=0.001), being 50 years and older (p<0.001), symptoms of shortness of breath (p<0.001), saturation value <95% (p<0.001), neutrophil count >7×109 L–1 (p=0.006), lymphocyte count <1.1×109 L–1 (p=0.020), procalcitonin value ≥0.015 ng/mL (p=0.001), D-dimer value ≥500 mg/L (p=0.009) were found to be statistically significant. Conclusion: The scoring system we have created is considered to be a comprehensive, easily applicable, and reliable method in determining the prognosis and the treatment strategy. [ABSTRACT FROM AUTHOR]

To assess the evolution of the epidemiology and management of patients hospitalized to Abidjan Heart Institute for acute coronary syndrome (ACS). Cross-sectional study comparing two periods: from January 2002 to December 2009 (period 1) and from January 2010 to December 2016 (period 2), including all patients aged 18 years old, admitted to Intensive Care Unit of Abidjan Heart Institute for ACS. One thousand eleven (1011) patients were included among the 6784 patients admitted to Intensive Care Unit of Abidjan Heart Institute for a cardiovascular disease. The overall prevalence of ACS was 14.9%. The prevalence in period 2 was significantly higher than in period 1 (22.6% and 7.3% respectively, p < 0.001). Diabetes (33.5%, p < 0.001) significantly, and smoking (30.7%, p = 0.30) had the largest rises from period 1 to period 2. ST-segment Elevation Myocardial Infarction was the main clinical presentation during both periods. The median time to treatment (p = 0.46) and length of hospital stay (p <0.001) decreased during period 2. Percutaneous coronary intervention (PCI) was performed in 173 patients (22.6%) during the period 2 and 42 patients (5.5%) underwent primary PCI. The rate of fibrinolysis increased significantly between the two periods (9.5%, p <0.001). In-hospital death increased during period 2 (10.4%, p = 0.07). The burden of ACS and its related mortality have risen alarmingly past years in Côte d'Ivoire. Healthcare policies should help improve the management and outcomes of patients. [ABSTRACT FROM AUTHOR]

Objectives: Objective of the study was to examine the laboratory findings with clinical characteristics and treatments of patients who were hospitalized in a tertiary intensive care unit with the diagnosis of coronavirus disease 2019 (COVID-19) and developed pneumothorax and to determine epidemiology and risks of pneumothorax. Methods: The study was conducted by retrospectively examining the electronic records of 681 COVID-19 patients who were followed up between 1 April 2020 and 1 January 2021 in 3 tertiary intensive care units (each was 24 beds). Patients demographic and clinical characteristics, laboratory findings, mechanical ventilator parameters and chest imaging were evaluated retrospectively. Results: Pneumothorax in 22 (3.2%) of 681 with COVID-19 patients was detected and acute respiratory distress syndrome (ARDS) in 481 (70.6). All the study patients met ARDS diagnostic criterias. Mortality rates were 43.4% (296/681) in all patients, 52.8% (254/481) in patients with ARDS, and 86.3% (19/22) in patients with pneumothorax. Pneumothorax occurred in the patients within a mean of 17.4±4.8 days. The computed tomographies of patients were observed common ground-glass opacities, heterogenic distribution with patch infiltrates, alveolar exudates, interstitial thickening in the 1st week of their symptom onset. Conclusion: We observed that pneumothorax significantly increased mortality in COVID-19 patients with ARDS. We believe that understanding and preventing the characteristics of pneumothorax will make an important contribution to mortality reduction. [ABSTRACT FROM AUTHOR]

L'anaphylaxie est une urgence médicale de plus en plus fréquente, notamment chez l'enfant et pour les causes alimentaires. Les principales étiologies d'anaphylaxie sont les aliments (notamment l'arachide, les fruits à coque, les laits de mammifères) chez l'enfant et, chez l'adulte, les venins d'hyménoptères et les médicaments. La mortalité par anaphylaxie reste cependant rare. D'après toutes les recommandations scientifiques, l'adrénaline administrée par voie intramusculaire pour toutes les situations en dehors de l'urgence périopératoire est le traitement de première ligne de l'anaphylaxie. L'injection doit être réalisée dès les premiers signes d'anaphylaxie, dans la partie moyenne de la face antéroexterne de la cuisse. Les auto-injecteurs d'adrénaline permettent une administration sécurisée, par tous, y compris les soignants, dans le contexte de l'urgence. Les autres traitements (antihistaminiques, bronchodilatateurs inhalés, etc.) sont de deuxième voire de troisième ligne. Les corticoïdes n'ont pas fait la preuve de leur intérêt dans le traitement de l'anaphylaxie. La surveillance en milieu hospitalier avec un monitoring étroit est au minimum de 6 à 8 heures en cas de résolution rapide des signes ; elle doit être cependant prolongée 24 heures en cas d'atteinte respiratoire ou cardiovasculaire initiale plus sévère. Les réactions biphasiques ou réfractaires à l'adrénaline sont rares. Après la phase de soins médicaux aigus, la prise en charge d'un patient avec une anaphylaxie aux urgences implique aussi la prescription d'une trousse d'urgence avec des auto-injecteurs d'adrénaline et une notice d'utilisation, en accord avec les recommandations, une éducation thérapeutique a minima avec la manipulation de dispositifs factices, et l'orientation vers une consultation d'allergologie avec, dans l'idéal, une filière de soins organisée. [ABSTRACT FROM AUTHOR]

Objective: The clinical course of coronavirus infection in liver transplant patients is not known accurately. The aim of this study was to examine the epidemiological incidence and outcomes of liver transplant patients after coronavirus disease-2019 (COVID-19) infection who have been registered in the data system of the Tissue, Organ Transplant and Dialysis Services Department. Methods: In this study, which was designed non-interventional, retrospective, and observational; the demographic information, clinical and radiological parameters, lifetime, hospital service and intensive care requirements and length of stay of the patients who were recorded in the information systems of the Ministry of Health, have were examined. A total of 3,426 liver transplant patients who were admitted to the hospital with suspected COVID-19 in Turkey between April 2020 and April 2021 were included in the study. Results: Between April 2020-April 2021, 3,426 cases of liver transplant who admitted to hospitals with symptoms of COVID-19 infection in Turkey were examined. The ratio of patients diagnosed with COVID-19 infection was 24.69% (846), with a mean age of 52.3%. The 13.48% (462 people) of 3,426 people who had liver transplants were hospitalized. The mean age of the hospitalized patients was 46.6, and the average length of hospital stay was 8.64 days. When the thorax computed tomography scans of 3,426 people with suspected COVID-19 and liver transplant were examined, pneumonia was detected in 344 (10%) people and they were treated as an inpatient. The mean age of the patients with pneumonia was 59 years. The number of liver transplant patients who died was 108 (3.1%), with a mean age of 65 years. The ratio of followup in the intensive care unit for organ transplant recipients was 0.32%, and 0.26% of them were intubated patients. Conclusion: Despite the use of immunosuppressive drugs in patients with liver transplant, the requirement for intensive care and the length of stay in the intensive care unit was found to be low, and the importance of strict follow-up and treatment in such patients was recognized once again. [ABSTRACT FROM AUTHOR]

Mucormycosis; is a rapidly progressive fungal infection due to filamentous fungi of the mucoraceae family. In this case report, we aimed to present the diagnosis and treatment modalities of a patient who developed rhinoorbital mucormycosis. A 54-year-old patient with a history of hypertension applied to the emergency department with a complaint of wound in the mouth that started four days ago. In the examinations performed here, the patient was diagnosed with diabetic ketoacidosis. In the examination of the patient, it was found that there was a necrotic wound on the left hard palate, a necrotic wound extending from the left inferior turbinate to the nasopharynx, and hyphae in the nasal passage. The patient underwent an aggressive debridement operation on the third day, due to the growth in the fungal culture. In the following clinical examination of the patient, ketone in the urine became negative, and his acidosis status improved. On the same day, the patient was treated with a positive coronavirus disease-2019 (COVID-19) polymerase chain reaction. After 15 days of treatment, the patient died due to COVID-19 pneumonia. Mucormycosis should be doubtful in patients presenting with uncontrolled diabetes mellitus and severe sinoorbital infection. All physicians following diabetic ketoacidosis should be vigilant against this rapidly progressing disease with high mortality. [ABSTRACT FROM AUTHOR]

Objective: COVID-19 infection causes severe pneumonia and multi-organ failure in adults, increases morbidity and mortality. Our study aimed to determine the factors affecting intensive care unit admission and mortality in hospitalized COVID-19 patients. Methods: The demographic, clinical, and laboratory data of hospitalized patients due to COVID-19 between May 1, 2020 and August 1, 2020 were evaluated retrospectively. Patients who were admitted to the intensive care unit or died during follow-up were included in the study group, and patients who were followed in the inpatient settings and survived consisted the control group. The data obtained at the time of hospitalization were evaluated statistically. Results: A total of473 patients were included in the study. The median age of the patients was 53 years (40-68 years), and 269 (56.9%) were male. During the follow-up, 93(19.7%) patients were admitted to the intensive care unit (ICU). Of the 468 patients for whom follow-up data were available, 62(13.2%) patients died. Patients with older age and comorbid diseases had higher ICU admission and mortality rates (p<0.001 and p<0.001). ICU admission rate was higher in patients with cough (p=0.002), myalgia (p=0.016), and dyspnea (p<0.001) during hospital admission. At the same time, dyspnea was more common in patients who died (p<0.001), and myalgia was more common in surviving patients (p=0.020). Laboratory values associated with both ICU admission and mortality were glucose (p<0.001, p<0.001), AST (p<0.001, p<0.001), serum creatinine (p<0.001, p<0.001), direct bilirubin (p<0.001, p=0.009), albumin (p<0.001, p<0.001), CRP (C-reactive protein) (p<0.001, p<0.001), procalcitonin (p<0.001, p<0.001), leukocyte count (p<0.001, p<0.001), lymphocyte count (p<0.001, p<0.001), neutrophil count (p=0.007, p<0.001), hemoglobin (p<0.001, p<0.001), troponin (p<0.001, p<0.001), D-dimer (p<0.001, p<0.001), ferritin (p<0.001, p<0.001) prothrombin time (p<0.001, p<0.001) and INR (international normalized ratio) (p<0.001, p<0.001) levels. Conclusions: Determining the parameters that define high-risk COVID-19 infected patients in the early period can contribute to reduce ICU admissions and mortality by improving patient management and resource utilization in hospitals. [ABSTRACT FROM AUTHOR]

Even though coagulopathy is a familiar entity in trauma, its relationship to burn injury remains unclear. Literature appears inconsistent as to the conclusions of the use of coagulation assays, either routine methods or newer viscoelastic coagulation assays (VCAs), thromboelastography (TEG) and rotational thromboelastometry (ROTEM), for prediction of patients' coagulation status and mortality. The use of diagnostic assays as mortality markers will be of great importance, since they would recognize at early stages patients with great medical demands and objectify burn injury severity. The aim of this study was to review the literature and evaluate burn patients' characteristics and coagulation markers in the early post burn period. The secondary outcome was to investigate the role of different coagulation assays in mortality prognosis. Literature search was performed using PubMed, ScienceDirect, Wiley Online Library, Google Scholar, Proquest Dissertation and Theses Global, Scopus and Cochrane Library databases. All types of articles referring to adults with any type of burn injury admitted in the first 24h assessing coagulation and mortality were included. PRISMA guidelines ensured the evidence-based process. Eleven studies met the eligibility criteria. This review demonstrated the indubitable relationship of coagulopathy with burn injury and its significant impact on mortality. The rapid and dynamic process of coagulation makes standard coagulation assays unable to detect short-lived haemostatic changes. More susceptible markers such as VCAs need to be applied to the routine assessment of burn patients in order to obtain an overview on coagulopathy and standardize the gained knowledge. [ABSTRACT FROM AUTHOR]

Objective: The morbidity and mortality of infective endocarditis (IE) is still high despite diagnostic and therapeutic advances. Additionally, underlying risk profile and prognostic determinants of IE may exhibit regional disparities. Demonstration of changing trends of IE might be useful for a better patient care. Therefore, we aimed to explore clinical characteristics and the prognostic factors of IE in Turkey. Material and Method: Predisposing factors, clinical, echocardiographic, microbiologic and prognostic information of the IE patients who were diagnosed between the years 2009-2019 were analysed. Prognostic factors associated with IE were determined by univariate and multivariate regression analysis. Results: A total of 80 patients (50 males, 30 females) were diagnosed with IE. Seven of the patients had recurrent episodes of IE. Rheumatic valve disease (20 (25.00%)) and prosthetic heart valve (13 (16.25%)) were the most common underlying conditions. Sixty-seven (83.75%) patients had leftsided vegetation, 10 (12.50%) patients had right-sided vegetation and 3 patients had cardiac device infection without the involvement of the valves. Native valve endocarditis was detected in 61 (76.25%) patients. Staphylococcus was the most common microbiologic agent followed by streptococcus and enterococcus. Twenty-one (28.25%) patients died during the index hospitalization. The complicated clinical course was the most significant predictor of in-hospital mortality. Conclusion: Knowledge of predisposing factors and underlying conditions of IE are evolving. Patients with complicated in-hospital course have the highest risk for in-hospital mortality. [ABSTRACT FROM AUTHOR]

Objective We aimed to evaluate the effect of hematoma volumes and preoperative ASA scores on mortality of the patients we operated on due to intraparenchymal hematoma. Materials and Methods This study was conducted by retrospectively scanning the files of 34 patients operated on for intraparenchymal hematoma in our hospital's neurosurgery clinic between February 2015 and February 2020. The preoperative glasgow coma score, hematoma volume, antiaggregant use, presence of hypertension, localization of bleeding and whether it was opened to the ventricle and ASA scores of the patients were collected to evaluate. Results Of the 34 patients included in the study, 20 were male, and 14 were female. Preoperative mean hematoma volumes of the patients were 120 cm3 (min: 41 - max: 278 cm3). In the follow-up of the patients, 28 of them were dead, and our mortality rate was 82%. A significant correlation was found between hematoma volumes and mortality (P<0.05). 11 of the patients were evaluated as ASA 2, 4 as ASA 3, 17 as ASA 4, and 2 patients as ASA 5. No significant correlation was found between the patients' ASA score and mortality (P>0.05). Conclusion Glasgow coma score and ASA score are important factors determining mortality. The glasgow coma score and ASA score should be evaluated together. Even if the glasgow coma score score is low, mortality decreases in patients without comorbid diseases. [ABSTRACT FROM AUTHOR]

La calciphylaxie urémique est une maladie rare, qui touche principalement les patients atteints de maladie rénale chronique traités par dialyse. Il s'agit d'une pathologie des micro-vaisseaux du derme et de l'hypoderme qui sont calcifiés et dont la thrombose entraîne la nécrose cutanée. Les lésions de calciphylaxie peuvent atteindre les membres et le tronc. Elles engendrent douleurs, infection, et s'associent à une dénutrition ainsi qu'à un important taux de mortalité. Cette revue générale décrit les présentations cliniques et paracliniques de la calciphylaxie. Elle résume les connaissances actuelles sur sa physiopathologie et les stratégies thérapeutiques qu'il est possible de proposer pour améliorer la prise en charge et tenter d'infléchir la mortalité de nos patients atteints de calciphylaxie urémique. Uremic calciphylaxis is a rare disease that affects patients with chronic end-stage renal disease. It is a pathology of the microvessels of the dermis and hypodermis which are calcified and whose thrombosis leads to skin necrosis. Calciphylaxis lesions can be distal and axial. They lead to pain, infection and are associated with denutrition and in high mortality rate (40–80% at 1 year). This general review describes the clinical and para-clinical presentations of calciphylaxis. It summarizes the current knowledge on its pathogenesis and the therapeutical options that can be proposed to improve the management and attempt to reduce the mortality of patients with uremic calciphylaxis. [ABSTRACT FROM AUTHOR]