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This atlas of postmortem angiography provides a summary of techniques that have been developed and used in order to visualize the human vascular system. The indications, advantages, limitations, and pitfalls of the different techniques are explained in detail through the use of examples from real cases and a wealth of informative images, as well as knowledge from the latest scientific works. Helpful recommendations are made concerning interpretation of the obtained radiological images, which will allow readers to start their own work in the field of post-mortem angiography or to ease and improve their practice. The atlas has been edited and written by members of an international working group created in 2012, “Technical Working Group Post-mortem Angiography Methods” (TWGPAM), who for the first time summarize their experiences concerning this new approach. Since findings explaining the reasons for both natural and traumatic death are often hidden within the vascular system, post-mortem angiography is of the highest importance in elucidating cause of death and may represent the key to minimally invasive autopsy.

This book is designed to assist clinicians who are new to intensive care by providing information on a range of important and novel topics of relevance in the day-to-day management of critically ill patients. Guidance is given on the appropriate response to various emergencies and circumstances, including stroke, acute liver failure, severe burns, extreme pain, and delirium. The role of simulation training in the intensive care unit is discussed, and detailed attention is devoted to the application of modern techniques for the assessment of vital organs in the critical care setting, such as echocardiography and lung ultrasound. An individual chapter focuses on regional anesthesia in intensive care, and in addition the book addresses subjects and issues that are frequently neglected. Examples include transfer of the critically ill patient, the role of forgotten electrolytes such as magnesium, the use of non-coumarin anticoagulants, and neuropsychological rehabilitation. The book will have broad appeal, including for general intensivists, anesthetists, acute medicine physicians, and medical students attached to acute specialties or preparing for exams in intensive care medicine.

This volume will introduce new terminology to the field of oncology, subdividing it into oncokinetics—the mechanics of the tumor cells as they arise and spread throughout the body—and oncodynamics—the impact of abnormal cues generated by tumors on the physiological functioning of the body. The volume will outline the importance of oncodynamics from both a cancer patient’s and a caregiver’s perspectives, stressing its significant impact on cancer patient functionality and the opportunity that cancer researchers will have to develop cross-disciplinary interactions and predict potential consequences of tumors and/or treatment.

This book is intended as a practical manual on the use of intraoperative ultrasound (IOUS) as a tool for imaging guidance during cranial and spinal neurosurgical procedures. Full account is taken of the emergence of novel clinical applications and recent technical advances, with extensive coverage of the impact of developments such as improved probe technology, fusion imaging and virtual navigation, 3D ultrasound imaging, contrast-enhanced ultrasound, and elastosonography. Basic principles of ultrasound are elucidated in order to assist in the optimal use of IOUS and clear guidance is provided on the interpretation of imaging findings in various pathologies. Informative comparisons are also made of the use of techniques such as fusion imaging and contrast-enhanced ultrasound in general radiology and neurosurgery. The aim of the authors is to enhance the general knowledge regarding intra-operative ultrasound brain imaging, standardizing its use and exploring new techniques, leading in some way toward compensating the lack of specific training in the application of ultrasound among the neurosurgical community. IOUS is a sensitive tool that can improve surgical precision and help to reduce morbidity.

This updated and expanded Fourth Edition is an alphabetical listing of commonly presenting neurological signs designed to guide the physician toward the correct clinical diagnosis. The dictionary is focused, problem-based and concise. The structured entries in this practical, clinical resource provide summaries of a wide range of neurological signs. Each entry includes: a definition of the sign; a brief account of the clinical technique required to elicit the sign; a description of the other signs which may accompany the index sign; an explanation of pathophysiological and/or pharmacological background; differential diagnosis; brief treatment details; and where known, the neuroanatomical basis of the sign. A Dictionary of Neurological Signs, Fourth Edition, is an indispensable reference for all students, trainees, and clinicians who care for patients with neurological disorders, and could also be used in preparation for exams, since each entry is a snapshot of a specific disorder or disease.

This book provides a state of the art overview of all aspects of testicular descent and cryptorchidism, including the mechanisms of descent and the causes, consequences, diagnosis, and treatment of undescended testis. The advances in understanding that have been achieved over the past two decades are clearly explained, covering the latest genetic information on the causes of normal and abnormal testicular descent, the role of INSL3 in transabdominal migration, and the evidence that a neurotransmitter released from the genitofemoral nerve mediates androgenic control of inguinoscrotal descent. Exciting changes in the management of both congenital and acquired cryptorchidism, such as the widespread use of laparoscopy for impalpable testes inside the abdominal cavity, are fully described. Evidence for the benefits of orchidopexy within the first year of life is reviewed, and an individual chapter is also devoted to hormonal treatment. Throughout the book due attention is given to ongoing controversies and divergences of opinion. This new edition of Descent of the Testis will be a timely update and valuable reference for all who are involved in research into testicular descent and management of cryptorchidism.

This book is a practical reference for any clinician who has struggled to care for an older adult in a home setting. The volume is written by experts in the field who describe fundamental principles and clinical approaches of geriatric home-based care and their application to specific diseases and conditions, including delirium, incontinence, falls, and chronic pain and disability. The book also details house calls for special populations, from the developmentally disabled to those afflicted with neurologic or psychiatric diseases. The volume explores house calls within the context of the US healthcare system. Geriatric Home-Based Medical Care: Principles and Practice is a valuable resource for geriatricians, geriatric nurses, primary care physicians, social workers, public health officials, and all medical professions who need tools to provide timely, compassionate, and high-quality care for their older adult patients.

This book provides comprehensive coverage of the management and related surgery of the rheumatoid hand, wrist, and elbow. It provides a much-needed, authoritative discussion of the epidemiology, surgical techniques, and outcomes of rheumatoid surgery. The book begins by introducing important background concepts, and then goes on to present up-to-date details on pre and postoperative management, indications, and treatment options. Each section ends with case-based coverage of common clinical scenarios and features numerous illustrations that showcase the sequential approach in managing this disease. Clinical Management of the Rheumatoid Hand, Wrist, and Elbow has broad appeal for rheumatologists and primary care physicians, and will assist them in providing appropriate referrals for surgery consultations. It also serves as a valuable reference for surgeons treating and managing patients with this unique disease.

This book describes the most recent insights into heart failure and the role played by autonomic nervous system pathophysiology in it, discussing the therapeutic implications. While current therapeutic approaches are able to control the effects of excessive adrenergic activation in heart failure syndrome, the underlying abnormalities of adrenergic control remain unaltered and can still cause progression to unmanageable end-stage heart failure. New therapeutic pathways are therefore being explored with a view to developing interventions that can directly modulate adrenergic over-activity and restore a more appropriate balance in neural control of the cardiovascular system. The book opens by examining current heart failure therapies. Advances in our understanding of autonomic regulation/dysregulation in heart failure are then discussed in detail, in the context of the search for more effective therapies. A concluding section addresses the role of autonomic nervous system denervation in heart failure. The authors are top scientists from leading research centers.

This dictionary provides a comprehensive list of the terms and definitions commonly used in clinical rheumatology and osteology, and the new edition has been extended to include more than 50 additional entries. The book contains systematic descriptions relating to diseases of the locomotor apparatus, including osteoporosis, and important laboratory findings; special reference is made to the immunological parameters, which are essential for correct definition of rheumatologic disorders. Another focus is the general principles of pharmacological treatment, including biologicals and modern therapy. Information is also provided on individual disorders in the field of mineral metabolism and metabolic osteopathies and basic issues in rheumatic surgery. General entries are included from the fields of physical medicine and physiotherapy, including a system of functional assessment. The Dictionary of Rheumatology will be of value for medical students and all who are training in this specialty. .

This book systematically describes the angioarchitecture of the spinal cord. Microradiographs of superficial and intrinsic arterial supply and venous drainage patterns provide the anatomical basis needed to understand spinal vascular disorders. These post mortem studies are supplemented by clinical spinal angiographies and case studies. Rapid advances in imaging technology have facilitated the solution of many diagnostic problems concerning diseases of the spine and spinal cord. But this is less true for vascular diseases of the spinal cord or diseases secondarily involving them. Furthermore, safely using interventional procedures or open surgery still requires a profound knowledge of the vascular anatomy involved. Accordingly, a growing demand for training in this special field has become evident over the last 25 years, making improvement of this knowledge in all Neuro-Specialities dealing with diagnostic and therapeutic problems of spinal disorders a highly desirable goal.

This concise guide covers the evolution and expanding scope of hospital medicine and the variety of clinical, ethical and administrative situations a Hospitalist encounters. 500 questions on inpatient care, co-management of patients and hospital system management are provided with the goal of assessing clinical and academic competency. Questions feature actual cases with evidence-based solutions. Useful to physicians, house staff and advanced nurse practitioners, this up-to-date referenced learning text encompasses all aspects of hospital care.

The development of proteomic analyses using advanced mass spectrometry techniques has revolutionized the way proteins are studied, namely, as individual molecules within a complex system. HIV-1 Proteomics: From Discovery to Clinical Application comprehensively covers protein analysis from the early classic experimental days to current state-of-the-art HIV-1 proteomics in a clear informative style that brings expert-level understanding to the novice. Discussion of important clinical applications and future directions for the field also make this an ideal read for the expert. After finishing this book, the reader will have a complete and functional understanding of protein analysis from traditional biochemistry to modern proteomics.

Rare Genitourinary Tumors offers the reader an up-to-date discussion of the less common neoplasms affecting the urinary tract and reproductive organs. Each authoritative chapter provides and in-depth discussion that is frequently not found in other urologic oncology textbooks. A valuable reference for urologists, oncologists, and those in specialty training, this volume provides ready access to information on etiology, incidence, risk factors, diagnosis, prognosis, insights from molecular pathology and, where applicable, data from clinical trials. The practical treatment guidelines included for each tumor type are written by experts and fully referenced.

This practical handbook offers quick and sound advice on the many issues faced when dialyzing the older patient. It is authored by well-known international experts who have covered the full range of end stage renal disorders including treatment options, patient management and maximization of quality of life. Accessible and easy-to-read, Dialysis in Older Adults serves as the go-to reference for clinicians and members of their team as they treat this challenging patient population.

This volume serves to provide an international overview of personal injury compensation in different geographical areas (15 countries already included), with a special focus on the methods used to ascertain the injury and the related damages. It also goes on to clarify the logical and methodological steps required for a sequential, in-depth ascertainment of any traumatic event and the related personal damage, both pecuniary and non-pecuniary. Personal injury is a legal term for an injury to the body, mind or emotions suffered by the plaintiff under tort and/or civil law regulations. Damages related to the injury can be pecuniary or non-pecuniary in nature. Although several comparative studies and research projects on tort and civil law and personal injury claims aimed at developing new tools for promoting harmonization of private law have been performed at an international level, heterogeneity and divergences still exist in the definition and compensation of personal injury and damage across different national legislative systems. The starting point for any awarding procedure should be a medical, or rather a medico-legal, assessment to gain evidence on the trauma or event causing the injury, the mechanism of injury, the pre-existing health status of the injured party, and the health consequences of the injury (temporary and permanent impairment, work incapacity, etc.). In order to pursue the ultimate goal of an international harmonization of personal injury compensation, it is of upmost importance to define the quality requirements for the medico-legal ascertainment methodology, which are essential for guaranteeing the objectivity, rigor, and reproducibility of the data and the evidence collection procedure. Currently, there are no supra-national medico-legal guidelines dealing with the ascertainment methodology of personal injury and damage under tort and civil law. .

This manual is aimed to provide health care professionals, at the scene and at hospitals, as well as allied organizations, a practical and operational approach for planning the response to mass casualty incidents (MCI’s), with emphasis to the types of events that are sudden in nature, resulting in a number of injured or contaminated patients that overwhelm the local health care system. From activation of the MCI plan to the specific medical care of multiple simultaneous patients, the manual offers checklists and algorithms of “what to do” during the first minutes after a MCI occurred. The manual is designed to be adapted and modified for specific institutions according to their size and capabilities. Written by a world expert in the field of MCI management, Mass Casualty Incidents: The Nuts and Bolts of Preparedness and Response for Acute Disasters is a valuable resource for all health care professionals and institutions that deal with mass casualty incidents. .

This book provides the ophthalmologist with the most recently available data on the macular dystrophies, a group of many different inherited or sporadic eye conditions linked by a problem with photoreceptors or other structures of the central retina. Internationally recognized experts in the field present the latest evidence and discuss their own personal experiences with regard to each of the principal dystrophies as well as some very rare entities. Topics covered include molecular biology, state-of-the-art diagnostic techniques, and the newest treatment options, including still experimental therapies. Attention is also devoted to a range of issues that continue to be debated. The editors have taken care to ensure that chapters are of a uniformly high standard while not sacrificing the originality of the individual authors. Macular Dystrophies will fully acquaint the reader with both the latest research findings and the current and emerging approaches to diagnosis and treatment.

This book provides an organizational model of the common ground needed to improve patient care and adapt to today’s healthcare environment. The relationship between a hospital CEO and a general surgeon and how they aligned, motivated and partnered with physicians to change the culture of a hospital and implement patient oriented systems is the essential element of this text. Sustainable transformation processes will also be presented for the various roles and contributions of the healthcare team. Written from a team perspective, Transforming the Patient Experience is a practical guide for healthcare team members and leaders to follow. .

The authors of this book set out a system of safety strategies and interventions for managing patient safety on a day-to-day basis and improving safety over the long term. These strategies are applicable at all levels of the healthcare system from the frontline to the regulation and governance of the system. There have been many advances in patient safety, but we now need a new and broader vision that encompasses care throughout the patient’s journey. The authors argue that we need to see safety through the patient’s eyes, to consider how safety is managed in different contexts and to develop a wider strategic and practical vision in which patient safety is recast as the management of risk over time. Most safety improvement strategies aim to improve reliability and move closer toward optimal care. However, healthcare will always be under pressure and we also require ways of managing safety when conditions are difficult. We need to make more use of strategies concerned with detecting, controlling, managing and responding to risk. Strategies for managing safety in highly standardised and controlled environments are necessarily different from those in which clinicians constantly have to adapt and respond to changing circumstances. This work is supported by the Health Foundation. The Health Foundation is an independent charity committed to bringing about better health and health care for people in the UK. The charity’s aim is a healthier population in the UK, supported by high quality health care that can be equitably accessed. The Foundation carries out policy analysis and makes grants to front-line teams to try ideas in practice and supports research into what works to make people’s lives healthier and improve the health care system, with a particular emphasis on how to make successful change happen. A key part of the work is to make links between the knowledge of those working to deliver health and health care with research evidence and analysis. The aspiration is t

This book provides an overview of the demographic, clinical, and psychosocial context of dementia care. With its focus on patient and family perspectives, this book describes evidence-based approaches towards prevention, detection, and treatment of dementia that is unlike any other book. The text presents memory clinics, care management, home-based interventions, palliative care, family caregiver programs, specific to dementia care. Additionally, the text examines strategies to support transitions to acute care and long-term care. The text also places a special emphasis on measures of quality, cultural sensitivity, and implications for health care policy. Written by experts in the field, Dementia Care: An Evidence-Based Approach is an excellent resource for clinicians, students, healthcare administrators, and policymakers who aim to improve the quality of life of both the person with dementia and their informal caregiver. .

This book discusses the key features of normal, age-dependent neonatal head and spine ultrasonography and the application of this modality to common and rare neonatal neurologic disorders. Ultrasonography is an incredibly versatile bedside imaging tool in detecting brain and spine abnormalities in neonates, monitoring the course of these lesions, and evaluating the maturation of the neonatal brain and spine. Organized to correspond to daily bedside practice, it presents a symptom-based approach and classifies neonatal neurologic disorders at presentation. For each disorder, clinical cases are presented that explore the differential diagnoses and are accompanied by high-quality ultrasound images that depict the abnormal findings. Topics include seizures, encephalopathy, hemiparesis, apnea, microcephaly, and neonatal spine abnormalities. Neonatal Head and Spine Ultrasonography is a succinct guide to this imaging modality and is a valuable resource for pediatric radiologists, neuroradiologists, neonatologists, and pediatricians.

This book is distinctive in that it is a truly practical guide to use of the laparoscopic approach for the treatment of many abdominal diseases. Rather than simply offering a general description of surgical laparoscopic techniques, it provides the knowledge required in order to introduce basic laparoscopic procedures into daily practice or to commence advanced laparoscopic surgery. For each surgical procedure, key points are highlighted, the necessary equipment is described, and the operating room setup essential to avoid errors or loss of time is explained. Many flow charts, tables, and figures are included to assist fast and intuitive comprehension. The book will be of interest to all of the "actors" in the operating room, including especially surgeons in training, established surgeons, nurses, and anesthetists.

This book is a scientific compendium documenting the state of the art in the discovery and development of vaccines, monoclonal antibodies, and enzymes for the treatment of Substance Use Disorders (SUDs). The book gives detailed consideration to some of the most cutting edge topics in addiction medicine, including vaccines for nicotine, cocaine, heroin, and methamphetamine dependence; monoclonal antibodies against cocaine, methamphetamine, and phencyclidine; and the enzymes butyrylcholinesterase and cocaine esterase. In addition, the text covers a wide range of new strategies designed to optimize the development and efficacy of biologics. Unlike any other resource, this book reviews how biologics offer exciting new therapeutic opportunities for various psychiatric conditions. Written by experts in the field, Biologics to Treat Substance Use Disorders is as an authoritative reference for psychiatrists, psychologists, and all other medical professionals working with patients suffering from Substance Use Disorders.

This useful book gives the reader basic insight into the musculoskeletal problems specific to each of the varied instruments and styles of dance, as well assome that affect the voice. The author’s thirty years practical experience around the theme of ‘Controversies in Performing Arts Medicine’ allows for in-depth knowledge in occupational rheumatological care for performing artists, especially instrumentalists and dancers with complex ailments. Performing Arts Medicine in Clinical Practice assists the reader in the management of highly complex elite athletes, the musicians and dancers whose care remains one of the greatest challenges in occupational musculoskeletal medicine.

This book will move the field of pediatric cochlear implantation forward by educating clinicians in the field as to current and emerging best practices and inspiring research in new areas of importance, including the relationship between cognitive processing and pediatric cochlear implant outcomes. The book discusses communication practices, including sign language for deaf children with cochlear implants and the role of augmentative/alternative communication for children with multiple disabilities. Focusing exclusively on cochlear implantation as it applies to the pediatric population, this book also discusses music therapy, minimizing the risk of meningitis in pediatric implant recipients, recognizing device malfunction and failure in children, perioperative anesthesia and analgesia considerations in children, and much more. Cochlear Implants in Children is aimed at clinicians, including neurotologists, pediatric otolaryngologists, audiologists and speech-language pathologists, as well as clinical scientists and educators of the deaf. The book is also appropriate for pre-and postdoctoral students, including otolaryngology residents and fellows in Neurotology and Pediatric Otolaryngology. .

This book is a concise introduction to the interventional radiology field and is designed to help medical students and residents understand the fundamental concepts related to image-guided interventional procedures and determine the appropriate use of imaging modalities in the treatment of various disorders. It covers the history of interventional radiology; radiation safety; equipment; medications; and techniques such as biopsy and drainage, vascular access, embolization, and tumor ablation. The book also describes the indications, patient preparation, post-procedure care, and complications for the most common interventional radiology procedures. .

This concise and practical book is the first of its kind to examine the use of assisted reproductive technologies (ART) in relation to blood-borne infectious diseases: human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV). The book opens with a discussion of the impact of these viruses on male and female fertility, followed by specific chapters of each of them, including ART with HIV and HCV serodiscordant couples (where either the male or female is positive) and the detection and impact of HBV and HCV in human gametes and embryos. An important character on laboratory safety when performing ART with blood-borne viruses follows, and the book concludes with a discussion of ART in austere and resource-poor settings, where these infections are often dominant due to lack of treatment and access to vaccines. Written and edited by an international array of experts in reproductive medicine, Assisted Reproductive Technologies and Infectious Diseases explores questions, techniques, and related issues with the aim of effectively helping clinicians working with serodiscordant couples wishing to have children. .

This book, in a concise format, explains how to perform manual small incision cataract surgery. The procedure is broken down into the chief elements and described in a step by step manner. Besides the description of the procedure, the book covers indications, necessary supplies, preparation, complication management, and postoperative care. The authors are experts from around the world, and the book will be of value both for surgeons new to this technique and for experienced surgeons who need a review of the procedure. While phacoemulsification surgery has become the standard of care, understanding how to perform manual extracapsular cataract extractions competently is crucial when faced with complications during phacoemulsification surgery, when operating in a region of the world without access to phacoemulsification or femtosecond lasers, or when a manual approach may be a better choice for the patient.

This book assists appropriate headache assessment and decision-making in pediatrics. It covers many aspects and causes of headache disorders in children and adolescents using case studies to illustrate important points in history, examination, diagnosis, choice of management approach, therapy selection, and communication of the most helpful advice to the child and parents. Case studies have been taken from real clinical practice and presented in a consistent style. They are discussed by the authors to highlight important points in history, important positive and negative points in examination, the diagnosis, and full analysis and justification of treatment options. Headache in Children and Adolescents: A Case-Based Approach is an ideal reference for primary care physicians, paediatricians, neurologists and paediatric neurologists in their daily practice, in their consulting rooms and wards.

This book offers essential guidance on selecting the most appropriate surgical management option for a variety of spinal conditions, including idiopathic problems, and degenerative disease. While the first part of the book discusses the neuroanatomy and biomechanics of the spine, pain mechanisms, and imaging techniques, the second guides the reader through the diagnostic process and treatment selection for disorders of the different regions of the spine, based on the principles of evidence-based medicine. I.e., it clearly explains why a particular technique should be selected for a specific patient on the basis of the available evidence, which is carefully reviewed. The book identifies potential complications and highlights technical pearls, describing newer surgical techniques and illustrating them with the help of images and accompanying videos. Though primarily intended for neurosurgeons, the book will also be of interest to orthopaedic surgeons, specialists in physical medicine, and pain specialists.

This book offers a unique and focused study of the use of ultrasound during the first trimester, a critical time in a fetus’ development. It includes basic examination guidelines as well as cutting-edge ultrasound modalities, including Doppler and three-dimensional ultrasound, for the period immediately preceding conception through early embryology. Beginning with a discussion of the safety and efficacy of diagnostic ultrasound and the use of this modality for the evaluation and treatment of infertility , recognized experts in the field explore conditions that may interfere with normal conception or development, including maternal diseases that would benefit from early scanning, elements of teratology, multiple gestations, ectopic pregnancy, gestational trophoblastic disease, fetal anomalies, and invasive procedures in the first trimester. Numerous illustrations and figures are provided to serve as aids for understanding key concepts. First-Trimester Ultrasound is a valuable resource for many, in or after training, in obstetrics and gynecology, radiology, emergency medicine, family medicine and genetics.

This comprehensive reference work edited by one of the leading authorities on obesity presents an up-to-date survey of the current scientific understanding of the metabolic syndrome, as well as an overview of the most significant changes to the field over the past 30 years. This volume is a thorough reference for obesity and the metabolic syndrome and will prove an indispensable resource for clinicians and researchers at levels worldwide. The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. In addition, when combined with other comorbidities such as hypertension and dyslipidemia, obesity often leads to a patient diagnosis of metabolic syndrome, a very troubling condition that has grown, and is continuing to grow, rapidly each year in prevalence worldwide. Metabolic syndrome is a cluster of conditions — increased blood pressure, a high blood sugar level, excess body fat around the waist and abnormal cholesterol levels — that occur together, increasing one’s risk of heart disease, stroke and diabetes. This resource covers the full range of scientific and clinical aspects: epidemiology, genetics, environmental factors, pathophysiology, diseases associated with obesity, and clinical management.

This book instructs postgraduate trainees in ophthalmology on the basic methodology required to perform intraocular surgery. The text is written clearly and concisely, investigating basic surgical skills for the eye to facilitate the training process. The subject material of each chapter has been carefully chosen to explain separate conceptual areas in surgery to allow easy understanding and rapid attainment of knowledge. The concepts can be transferred from one surgical method to another, giving the reader the flexibility to adapt to new methods quickly. Intraocular Surgery - A Basic Surgical Guide provides various insights to allow the development of a thoughtful and considered approach to surgery. It encourages the reader to more intelligently scrutinize which surgical methods to apply, and to utilize the most effective procedures in clinical practice. After reading this book, the reader will be well-equipped to perform the simple steps of surgery, improving the overall quality of surgery.

This volume provides a comprehensive, state-of-the art review on the field of diagnostic hematopathology as it is applied to patients with plasma cell neoplasms. The book places particular emphasis on immunophenotypic data – immunohistochemistry and flow cytometry – as well as cytogenetics, and discusses how these ancillary data can predict prognosis and chemotherapeutic response. It also provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. Written by experts in their fields, Plasma Cell Neoplasms serves as a very useful resource for physicians and researchers interested in plasma cell myeloma diagnosis, therapy, and research. .

This text provides a comprehensive review of the ethical issues involved with the development, evaluation, and introduction of new treatments of gastrointestinal diseases. How several landmark surgical innovations were developed are described to show the challenges faced, and the ethical dilemmas these innovators dealt with. The challenges of dealing with regulatory issues, and how to work with industry partners, and investors when working on a new therapy is described. Once a new technology has been brought to the market, standards need to be developed regarding the training, credentialing and adoption of the new technology. There are insufficient standards of how to balance the desire to provide patients the latest therapy with the obligation that patients receive informed consent about the new technology, and the relationship that the physician may have had with product development. The book describes the national perspective of paying for new technology, and provides one insurance company’s approach to the introduction of innovative therapy. The Sages Manual Ethics of Surgical Innovation will be a resource for surgeons, researchers and health policy personnel to understand the ethical issues related to the development, introduction and adoption of innovative therapies for gastrointestinal diseases. Although the context for discussion is the application of innovation to gastrointestinal disease, the ethical issues are applicable to any discussion of innovative medical or procedural therapies.

This useful book examines the full spectrum of data available on uterine adenomyosis, covering early to modern literature. The authors look at the recent scientific advancements in the pathophysiology of this disease, giving the reader insight into its diagnosis before hysterectomy and its clinical impact on fertility. Uterine Adenomyosis is an in-depth resource guide for the practicing gynecologist, post-graduate researcher and any medical professional or scientist seeking to broaden their understanding of adenomyosis.

Written for residents and practitioners of otolaryngology, medical oncology, radiation oncology, and maxiollofacial surgery, this book provides the reader with a comprehensive, concise discussion of the best evidence available on which to base clinical decisions needed when managing patients with squamous cell carcinomas of the oral cavity, pharynx and larynx. Because of its accessible and practical format, this book is considerably different than other related titles on the market. Formatted with questions at the beginning of each chapter that are then answered with evidence and best practices available for each case, each chapter addresses situations the clinician is likely to face in the diagnostic evaluation and treatment of a patient with cancer of the head and neck. Most clinical decisions in the management of cancers of the head and neck region are based on the results of a few controlled, randomized clinical trial trials (Evidence Level I). However, most decision-making is based on the results of case-control studies (Evidence Level II), descriptive studies, reports of expert committees, or opinions of respected authorities (Evidence Level III). This information is scattered throughout the literature and often comingled with information about other topics. Therefore, there is a need for a publication in which the evidence pertinent to making decisions regarding a particular clinical problem is distilled from the literature and presented in a single concise, clinical, situation-driven source. Cancer of the Oral Cavity, Pharynx and Larynx: Evidence-Based Decision Making is just such a resource.

This text provides a concise, straightforward and clearly written approach for the evaluation of common topics in pediatric endocrinology. Pediatricians, family physicians, residents, fellows and medical students will benefit from the discussion of endocrine physiology and its application to common clinical practice. The text presents the major signs and symptoms and the diagnosis and management of pediatric endocrine disorders. The information presented can prepare a provider for communication with parents of a child with an endocrine condition and may allow the practitioner to avoid an unnecessary consultation. The concepts covered in the text are designed to address the first 10 headings in the content outline of the Sub-board of Pediatric Endocrinology of The American Board of Pediatrics with varying degrees of specificity. The Suggested Reading sections at the conclusion of each chapter direct the reader to outstanding larger and more detailed texts, manuscripts and websites which offer increased detail.

Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology, as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 2 contains sixteen chapters addressing advanced knowledge on “Stem Cell Science and Technology” addressing basic classification technology, cell biology of stemness state and regulatory molecular pathways. Mechanisms and technology of cell programming are explained, as well as the pathology of cancer cells and dedifferentiation signalling. Pluripotent, multipotent germline and tissue specific human stem cells are classified and qualified according to their respective biological function or tissue regeneration. Leading stem cell scientists from all over the world explain advanced technology, latest knowledge, and clinical implications of human stem cell science in a unique, comprehensive and detailed outline.

This text covers basic principles and practice of on-call psychiatric care in the geriatric patient in various medical settings. It compiles the most likely complaints and provides assessment and management tools for each situation. Written and edited by expert geriatric psychiatrists, emergency psychiatrists, consultation/liaison psychiatrists, geriatricians, and other multidisciplinary specialists, this is the first handbook devoted to on-call geriatric psychiatry. Chapters contain an important summary of key points for managing clinical situations, case studies, and reflective questions. This text brings together relevant principles of on-call geriatric psychiatry provided in clinical settings such as emergency, acute and subacute inpatient, outpatient, residential, correctional, and consultation/liaison. It includes clinical topics such as psychopharmacology, psychotherapy, substance abuse, and includes coverage of medical ethics and the law, utilization of contemporary technology, and administrative and public health policy. On-Call Geriatric Psychiatry is the first practical guide to knit together evidence-based medicine and geriatric psychiatric principles and practice guidelines and is a valuable resource for trainees, psychiatrists, geriatricians, emergency departments, nursing home physicians, and other health professionals working with older adult patients.

This volumeprovides a comprehensive, state-of-the-art review of this topic.It reviews natural history, etiology, management, and prevention of urinary dysfunction.The textcovers themultiple new treatments for prostate cancer thathave been introduced as well as reviewing the etiology, risk factors, and possible prevention of urinary dysfunction in men with prostate cancer.This textbook provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chaptersare written by experts in their fields and include the most up-to-date clinical information Urinary Dysfunction in Prostate Cancer – A Management Guidewill serve as a valuable resource for clinicians, surgeons and researchers with an interest in urinary dysfunction caused by prostate cancer or its treatments.

Edited and written by leading educators, this popular book for the anesthesiology rotation has been thoroughly updated and retains its distinctive case-based approach. The Second Edition features a thorough revision of the discussion of ventilator management, improved coverage of extubation criteria, and the latest guidelines and algorithms for preoperative assessment. Considerations for quality improvement and patient safety have been expanded throughout the book. Anesthesia Student Survival Guide provides a complete introduction to the specialty and is aimed at medical and nursing students as well as practitioners in critical care who seek a succinct overview of anesthesiology. From reviews of the First Edition: “…an excellent resource for the student wanting a deeper understanding of what is essentially a post-graduate subject, for example, an elective student.” --British Journal of Anaesthesia “This is an excellent introduction to the specialty for third-year medical students, covering a broad range of material at a sufficient depth to be useful, and providing a good structure for a comprehensive course of self-directed study.” --Doody’s Review Service “The writing style is uniformly strong, which makes the book easy to read.…[It] serves not only as an excellent resource for students and other learners seeking an introduction to anesthesia but also as a platform for teaching the basics. It will be a welcome addition to the libraries of teaching departments.” --Canadian Journal of Anesthesia .

This book is a detailed guide to the intra- and postoperative complications that may arise during the most frequently used laparoscopic techniques, with explanation of how and at what point in time they may arise, what can be done to avoid them, and how to deal with them if they do occur. Individual chapters, each written by an expert in the area, focus on the complications associated with the creation of pneumoperitoneum, laparoscopic cholecystectomy-biliary tract, laparoscopic management of gastroesophageal reflux disease, colorectal laparoscopic surgery, minimally invasive spleen surgery, and laparoscopic hernia repair (TAPP and TEP). Attention is drawn to useful tips and tricks and to the most critical points in surgical procedures, with a view to optimizing performance of techniques and avoiding pitfalls and complications. The concise, didactic text is enriched with informative drawings and photos and also with short video clips, available to the reader online, that will aid understanding. The book will be of value both for surgical residents and for more experienced surgeons.

Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.

The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and di

This complete resource captures state-of-the-art strategies and the accelerated pace of discovery that is revolutionizing what is known about ischemic stroke and its treatment. Therapeutics for acute management, secondary prevention, recovery, rehabilitation, asymptomatic cerebral ischemia, and implementation of stroke systems of care are all discussed in this comprehensive yet practical guide. Chapters are authored by leading academicians with extensive clinical practice experience from all over the world and feature the scientific evidence behind prevailing therapeutic strategies for managing ischemic cerebrovascular disease. The specialist or general practitioner will gain critical knowledge in stroke management, current clinical challenges and promising new therapies under investigation.

This concise pocketbook will provide readers with an overview and background of meningococcal disease, treatment options and emerging therapies, and methods of prevention. The book was originally commissioned due to recent developments in vaccinations to prevent meningococcal disease. This book reviews the disease progression and associated risk factors; its pathogenesis and diagnosis; methods of treatment and prevention, both current and emerging; and the future directions of meningococcal disease management. The book is ideal for busy healthcare professionals, as it covers all aspects of the disease and its treatment in a condensed and manageable format, whilst including the most up-to-date treatment guidelines and algorithms.

In 2011, the General Surgical Oncology Fellowship Program at the University of Toronto sought to develop a practical approach to common oncology problems faced by general surgeons in a collaboration between current and previous fellows, as well as staff at the University of Toronto, including experts from Princess Margaret Cancer Centre, Odette Cancer Centre (at Sunnybrook Health Sciences Centre), Mount Sinai Hospital, Toronto General Hospital, St. Michael’s Hospital, and St. Joseph’s Hospital. This effort culminated in the publication of the Surgical Oncology Manual in March, 2012. The first edition received excellent feedback on its utility from both trainees and practicing surgeons alike. With the ever-changing landscape of surgical oncology, this edition is updated with new evidence and topics in the field, providing a succinct review of surgical oncology with a summary of key evidence in the work-up, treatment, and follow-up for each cancer site as well as a section of “Pearls”, derived from the wide breadth of experience, skills, and abilities of the contributors. A clear, concise format has proven invaluable to the intended audience: surgical oncology fellows, practicing general surgeons, general surgery residents, and medical students. .