301. Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients
- Author
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Roc Reguant, Jessica X. Hjaltelin, Alejandro Aguayo-Orozco, Karina Banasik, Isabella Friis Jørgensen, Mette Lademann, Anders Boeck Jensen, Søren Brunak, Amalie Dahl Haue, and Troels Siggaard
- Subjects
0301 basic medicine ,Time Factors ,Computer science ,Denmark ,Science ,Population ,General Physics and Astronomy ,Diseases ,Disease ,Article ,General Biochemistry, Genetics and Molecular Biology ,Set (abstract data type) ,Danish ,03 medical and health sciences ,0302 clinical medicine ,Computational platforms and environments ,EPIDEMIOLOGY ,Humans ,Patient register ,030212 general & internal medicine ,Signs and symptoms ,lcsh:Science ,education ,computer.programming_language ,education.field_of_study ,Multidisciplinary ,Information retrieval ,Disease trajectory ,Disease progression ,food and beverages ,General Chemistry ,CARE ,JSON ,language.human_language ,ONTOLOGY ,030104 developmental biology ,REGISTRY ,Disease Progression ,language ,lcsh:Q ,COMORBIDITY ,computer ,Software ,Algorithms - Abstract
We present the Danish Disease Trajectory Browser (DTB), a tool for exploring almost 25 years of data from the Danish National Patient Register. In the dataset comprising 7.2 million patients and 122 million admissions, users can identify diagnosis pairs with statistically significant directionality and combine them to linear disease trajectories. Users can search for one or more disease codes (ICD-10 classification) and explore disease progression patterns via an array of functionalities. For example, a set of linear trajectories can be merged into a disease trajectory network displaying the entire multimorbidity spectrum of a disease in a single connected graph. Using data from the Danish Register for Causes of Death mortality is also included. The tool is disease-agnostic across both rare and common diseases and is showcased by exploring multimorbidity in Down syndrome (ICD-10 code Q90) and hypertension (ICD-10 code I10). Finally, we show how search results can be customized and exported from the browser in a format of choice (i.e. JSON, PNG, JPEG and CSV)., The Danish health system has been collecting health-related data on the entire Danish population for years. Here the authors present the Danish Disease Trajectory Browser (DTB), which allows users to explore population-wide disease progression patterns from data collected between 1994 and 2018.
- Published
- 2020
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