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2,779 results on '"d'Alessandro, G."'

303. Synthetic growth hormone-releasing hormone agonist ameliorates the myocardial pathophysiology characteristic of heart failure with preserved ejection fraction

Author

Raul A Dulce, Rosemeire M Kanashiro-Takeuchi, Lauro M Takeuchi, Alessandro G Salerno, Amarylis C B A Wanschel, Shathiyah Kulandavelu, Wayne Balkan, Marilia S S R Zuttion, Renzhi Cai, Andrew V Schally, and Joshua M Hare

Subjects
Physiology, Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Aims To test the hypothesis that the activation of the growth hormone-releasing hormone (GHRH) receptor signalling pathway within the myocardium both prevents and reverses diastolic dysfunction and pathophysiologic features consistent with heart failure with preserved ejection fraction (HFpEF). Impaired myocardial relaxation, fibrosis, and ventricular stiffness, among other multi-organ morbidities, characterize the phenotype underlying the HFpEF syndrome. Despite the rapidly increasing prevalence of HFpEF, few effective therapies have emerged. Synthetic agonists of the GHRH receptors reduce myocardial fibrosis, cardiomyocyte hypertrophy, and improve performance in animal models of ischaemic cardiomyopathy, independently of the growth hormone axis. Methods and results CD1 mice received 4- or 8-week continuous infusion of angiotensin-II (Ang-II) to generate a phenotype with several features consistent with HFpEF. Mice were administered either vehicle or a potent synthetic agonist of GHRH, MR-356 for 4-weeks beginning concurrently or 4-weeks following the initiation of Ang-II infusion. Ang-II-treated animals exhibited diastolic dysfunction, ventricular hypertrophy, interstitial fibrosis, and normal ejection fraction. Cardiomyocytes isolated from these animals exhibited incomplete relaxation, depressed contractile responses, altered myofibrillar protein phosphorylation, and disturbed calcium handling mechanisms (ex vivo). MR-356 both prevented and reversed the development of the pathological phenotype in vivo and ex vivo. Activation of the GHRH receptors increased cAMP and cGMP in cardiomyocytes isolated from control animals but only cAMP in cardiac fibroblasts, suggesting that GHRH-A exert differential effects on cardiomyocytes and fibroblasts. Conclusion These findings indicate that the GHRH receptor signalling pathway(s) represents a new molecular target to counteract dysfunctional cardiomyocyte relaxation by targeting myofilament phosphorylation and fibrosis. Accordingly, activation of GHRH receptors with potent, synthetic GHRH agonists may provide a novel therapeutic approach to management of the myocardial alterations associated with the HFpEF syndrome.

Published
2022
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306. Longitudinal Study on Seasonal Variation of Marine Biotoxins and Related Harmful Algae in Bivalve Mollusks Bred in Sardinia (Italy, W Mediterranean Sea) from 2015 to 2020 and Assessment of Potential Public Health Risks

Author

Alessandro G. Mudadu, Anna Maria Bazzoni, Virgilio Congiu, Giuseppe Esposito, Alberto Cesarani, Rita Melillo, Giuseppa Lorenzoni, Simona Cau, Barbara Soro, Bruna Vodret, Domenico Meloni, and Sebastiano Virgilio

Subjects
bivalve mollusks, okadaic acid, pectenotoxins, potentially toxic algae, public health, Naval architecture. Shipbuilding. Marine engineering, VM1-989, Oceanography, GC1-1581
Abstract

Annual and interannual dynamics of shellfish toxins and associated harmful algal species (HAS) were analyzed from 2015 to 2020 in Tortolì Lagoon (Sardinia, west Mediterranean Sea). Analysis of seasonal occurrence of different harmful algae, such as Dinophysis spp., Prorocentrum spp., Pseudo-nitzschia spp. and Alexandrium minutum, was performed. The species Dinophysis acuminata and Dinophysis sacculus were responsible for the accumulation of lipophilic toxins belonging to the okadaic acid group (OAs) and pectenotoxins2 (PTX2) in bivalve mollusks. The highest HAS detection was recorded in the winter months; in particular, Dinophysis spp. was mostly present in January–February. Out of 1090 analyzed mollusk samples, 39 were non-compliant, exceeding the legal limits (160 μg OA eq/kg e.p.) reported in Regulation 853/2004 of the European Commission. A statistical analysis related to the presence of OA and PTX2 in mollusks with various environmental parameters (pH, water temperature, dissolved oxygen, algal density) was implemented, proving a clear winter seasonality. The present study highlights the necessity to better understand the different factors able to influence the production and accumulation of toxins in bivalve mollusks bred in an important Sardinian production area. The contribution of this research is important not only from an environmental and productive point of view but also from the view of implementing management in order to mitigate any harm to human health.

Published
2021
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307. Oxidative Stress Biomarkers in Chronic Obstructive Pulmonary Disease Exacerbations: A Systematic Review

Author

Elisabetta Zinellu, Angelo Zinellu, Alessandro G. Fois, Maria Carmina Pau, Valentina Scano, Barbara Piras, Ciriaco Carru, and Pietro Pirina

Subjects
COPD, exacerbations, oxidative stress, biomarkers, Therapeutics. Pharmacology, RM1-950
Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease characterized by a not fully reversible airflow limitation associated with an abnormal inflammatory response. Exacerbations of COPD are of major importance in the acceleration of disease progression, in healthcare costs, and negatively affect the patient’s quality of life. Exacerbations are characterized by a further increase in the airway inflammation likely driven by oxidative stress. In order to deepen the knowledge about this topic, several studies have focused on oxidative stress biomarkers levels. This review summarizes the literature findings about oxidative stress biomarkers in exacerbated COPD patients compared to ones in the stable state. Methods: a systematic search in electronic databases Pubmed, Web of Science, Scopus and Google Scholar from inception to January 2021, was conducted using the terms: “oxidative stress”, “chronic obstructive pulmonary disease” or “COPD”, “exacerbation”. Results: 23 studies were selected for the systematic review. They showed the presence of an imbalance between oxidant and antioxidant molecules in favor of the former in exacerbation of COPD. Conclusions: future studies using standardized methods in better characterized population are needed. However, this review suggests that targeting oxidative stress could be useful in monitoring the disease progression in COPD patients and especially in those more susceptible to exacerbations.

Published
2021
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308. Methodological Fallacies in the Determination of Serum/Plasma Glutathione Limit Its Translational Potential in Chronic Obstructive Pulmonary Disease

Author

Salvatore Sotgia, Alessandro G. Fois, Panagiotis Paliogiannis, Ciriaco Carru, Arduino A. Mangoni, and Angelo Zinellu

Subjects
glutathione, low-molecular-weight thiols, COPD, systemic oxidation, redox state, Organic chemistry, QD241-441
Abstract

This study aimed to review and critically appraise the current methodological issues undermining the suitability of the measurement of serum/plasma glutathione, both in the total and reduced form, as a measure of systemic oxidative stress in chronic obstructive pulmonary disease (COPD). Fourteen relevant articles published between 2001 and 2020, in 2003 subjects, 1111 COPD patients, and 892 controls, were reviewed. Nine studies, in 902 COPD patients and 660 controls, measured glutathione (GSH) in the reduced form (rGSH), while the remaining five, in 209 COPD patients and 232 controls, measured total GSH (tGSH). In the control group, tGSH ranged between 5.7 and 7.5 µmol/L, whilst in COPD patients, it ranged between 4.5 and 7.4 µmol/L. The mean tGSH was 6.6 ± 0.9 µmol/L in controls and 5.9 ± 1.4 µmol/L in patients. The concentrations of rGSH in the control group showed a wide range, between 0.47 and 415 µmol/L, and a mean value of 71.9 ± 143.1 µmol/L. Similarly, the concentrations of rGSH in COPD patients ranged between 0.49 and 279 µmol/L, with a mean value of 49.9 ± 95.9 µmol/L. Pooled tGSH concentrations were not significantly different between patients and controls (standard mean difference (SMD) = −1.92, 95% CI −1582 to 0.0219; p = 0.057). Depending on whether the mean concentrations of rGSH in controls were within the accepted normal range of 0.5–5.0 µmol/L, pooled rGSH concentrations showed either a significant (SMD = −3.8, 95% CI −2.266 to −0.709; p < 0.0001) or nonsignificant (SMD = −0.712, 95% CI −0.627 to 0.293; p = 0.48) difference. These results illustrate the existing and largely unaddressed methodological issues in the interpretation of the serum/plasma concentrations of tGSH and rGSH in COPD.

Published
2021
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310. Identifying frequency decorrelated dust residuals in B-mode maps by exploiting the spectral capability of bolometric interferometry

Author

Regnier, M., Manzan, E., Hamilton, J. -Ch, Mennella, A., Errard, J., Zapelli, L., Torchinsky, S. A., Paradiso, S., Battistelli, E., De Bernardis, P., Colombo, L., De Petris, M., D'Alessandro, G., Garcia, B., Gervasi, M., Masi, S., Mousset, L., Granese, N. Miron, O'Sullivan, C., Piat, M., Rasztocky, E., Romero, G. E., Scoccola, C. G., Zannoni, M., Regnier, M., Manzan, E., Hamilton, J. -Ch, Mennella, A., Errard, J., Zapelli, L., Torchinsky, S. A., Paradiso, S., Battistelli, E., De Bernardis, P., Colombo, L., De Petris, M., D'Alessandro, G., Garcia, B., Gervasi, M., Masi, S., Mousset, L., Granese, N. Miron, O'Sullivan, C., Piat, M., Rasztocky, E., Romero, G. E., Scoccola, C. G., and Zannoni, M.

Abstract

Astrophysical polarized foregrounds represent the most critical challenge in Cosmic Microwave Background (CMB) B-mode experiments. Multi-frequency observations can be used to constrain astrophysical foregrounds to isolate the CMB contribution. However, recent observations indicate that foreground emission may be more complex than anticipated. We investigate how the increased spectral resolution provided by band splitting in Bolometric Interferometry (BI) through a technique called spectral imaging can help control the foreground contamination in the case of unaccounted Galactic dust frequency decorrelation along the line-of-sight. We focus on the next generation ground-based CMB experiment CMB-S4, and compare its anticipated sensitivities, frequency and sky coverage with a hypothetical version of the same experiment based on BI. We perform a Monte-Carlo analysis based on parametric component separation methods (FGBuster and Commander) and compute the likelihood on the recovered tensor-to-scalar ratio. The main result of this analysis is that spectral imaging allows us to detect systematic uncertainties on r from frequency decorrelation when this effect is not accounted for in component separation. Conversely, an imager would detect a biased value of r and would be unable to spot the presence of a systematic effect. We find a similar result in the reconstruction of the dust spectral index, where we show that with BI we can measure more precisely the dust spectral index also when frequency decorrelation is present. The in-band frequency resolution provided by BI allows us to identify dust LOS frequency decorrelation residuals where an imager of similar performance would fail. This opens the prospect to exploit this potential in the context of future CMB polarization experiments that will be challenged by complex foregrounds in their quest for B-modes detection., Comment: 13 Pages, 15 figures, 4 tables. Accepted by A&A

Published
2023

311. Tensor-to-scalar ratio forecasts for extended LiteBIRD frequency configurations

Author

Fuskeland, U., Aumont, J., Aurlien, R., Baccigalupi, C., Banday, A. J., Eriksen, H. K., Errard, J., Génova-Santos, R. T., Hasebe, T., Hubmayr, J., Imada, H., Krachmalnicoff, N., Lamagna, L., Pisano, G., Poletti, D., Remazeilles, M., Thompson, K. L., Vacher, L., Wehus, I. K., Azzoni, S., Ballardini, M., Barreiro, R. B., Bartolo, N., Basyrov, A., Beck, D., Bersanelli, M., Bortolami, M., Brilenkov, M., Calabrese, E., Carones, A., Casas, F. J., Cheung, K., Chluba, J., Clark, S. E., Clermont, L., Columbro, F., Coppolecchia, A., D'Alessandro, G., de Bernardis, P., de Haan, T., de la Hoz, E., De Petris, M., Della Torre, S., Diego-Palazuelos, P., Finelli, F., Franceschet, C., Galloni, G., Galloway, M., Gerbino, M., Gervasi, M., Ghigna, T., Giardiello, S., Gjerløw, E., Gruppuso, A., Hargrave, P., Hattori, M., Hazumi, M., Hergt, L. T., Herman, D., Herranz, D., Hivon, E., Hoang, T. D., Kohri, K., Lattanzi, M., Lee, A. T., Leloup, C., Levrier, F., Lonappan, A. I., Luzzi, G., Maffei, B., Martínez-González, E., Masi, S., Matarrese, S., Matsumura, T., Migliaccio, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Nagata, R., Namikawa, T., Nati, F., Natoli, P., Nerval, S., Novelli, A., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Patanchon, G., Pelgrims, V., Piacentini, F., Piccirilli, G., Polenta, G., Puglisi, G., Raffuzzi, N., Ritacco, A., Rubino-Martin, J. A., Savini, G., Scott, D., Sekimoto, Y., Shiraishi, M., Signorelli, G., Stever, S. L., Stutzer, N., Sullivan, R. M., Takakura, H., Terenzi, L., Thommesen, H., Tristram, M., Tsuji, M., Vielva, P., Weller, J., Westbrook, B., Weymann-Despres, G., Wollack, E. J., Zannoni, M., Fuskeland, U., Aumont, J., Aurlien, R., Baccigalupi, C., Banday, A. J., Eriksen, H. K., Errard, J., Génova-Santos, R. T., Hasebe, T., Hubmayr, J., Imada, H., Krachmalnicoff, N., Lamagna, L., Pisano, G., Poletti, D., Remazeilles, M., Thompson, K. L., Vacher, L., Wehus, I. K., Azzoni, S., Ballardini, M., Barreiro, R. B., Bartolo, N., Basyrov, A., Beck, D., Bersanelli, M., Bortolami, M., Brilenkov, M., Calabrese, E., Carones, A., Casas, F. J., Cheung, K., Chluba, J., Clark, S. E., Clermont, L., Columbro, F., Coppolecchia, A., D'Alessandro, G., de Bernardis, P., de Haan, T., de la Hoz, E., De Petris, M., Della Torre, S., Diego-Palazuelos, P., Finelli, F., Franceschet, C., Galloni, G., Galloway, M., Gerbino, M., Gervasi, M., Ghigna, T., Giardiello, S., Gjerløw, E., Gruppuso, A., Hargrave, P., Hattori, M., Hazumi, M., Hergt, L. T., Herman, D., Herranz, D., Hivon, E., Hoang, T. D., Kohri, K., Lattanzi, M., Lee, A. T., Leloup, C., Levrier, F., Lonappan, A. I., Luzzi, G., Maffei, B., Martínez-González, E., Masi, S., Matarrese, S., Matsumura, T., Migliaccio, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Nagata, R., Namikawa, T., Nati, F., Natoli, P., Nerval, S., Novelli, A., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Patanchon, G., Pelgrims, V., Piacentini, F., Piccirilli, G., Polenta, G., Puglisi, G., Raffuzzi, N., Ritacco, A., Rubino-Martin, J. A., Savini, G., Scott, D., Sekimoto, Y., Shiraishi, M., Signorelli, G., Stever, S. L., Stutzer, N., Sullivan, R. M., Takakura, H., Terenzi, L., Thommesen, H., Tristram, M., Tsuji, M., Vielva, P., Weller, J., Westbrook, B., Weymann-Despres, G., Wollack, E. J., and Zannoni, M.

Abstract

LiteBIRD is a planned JAXA-led CMB B-mode satellite experiment aiming for launch in the late 2020s, with a primary goal of detecting the imprint of primordial inflationary gravitational waves. Its current baseline focal-plane configuration includes 15 frequency bands between 40 and 402 GHz, fulfilling the mission requirements to detect the amplitude of gravitational waves with the total uncertainty on the tensor-to-scalar ratio, $\delta r$, down to $\delta r<0.001$. A key aspect of this performance is accurate astrophysical component separation, and the ability to remove polarized thermal dust emission is particularly important. In this paper we note that the CMB frequency spectrum falls off nearly exponentially above 300 GHz relative to the thermal dust SED, and a relatively minor high frequency extension can therefore result in even lower uncertainties and better model reconstructions. Specifically, we compare the baseline design with five extended configurations, while varying the underlying dust modeling, in each of which the HFT (High-Frequency Telescope) frequency range is shifted logarithmically towards higher frequencies, with an upper cutoff ranging between 400 and 600 GHz. In each case, we measure the tensor-to-scalar ratio $r$ uncertainty and bias using both parametric and minimum-variance component-separation algorithms. When the thermal dust sky model includes a spatially varying spectral index and temperature, we find that the statistical uncertainty on $r$ after foreground cleaning may be reduced by as much as 30--50 % by extending the upper limit of the frequency range from 400 to 600 GHz, with most of the improvement already gained at 500 GHz. We also note that a broader frequency range leads to better ability to discriminate between models through higher $\chi^2$ sensitivity. (abridged), Comment: 18 pages, 13 figures. Published in A&A

Published
2023
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312. Incertezza

Author

Nijem, N, Larizza, L, Sbarbaro, A, Guano, E, Tcheraghali, A, Tarallo, P, Menghistie, K, Caridi, P, Kumalé, C, Fofi, G, Campanati, E, Ottieri, M.P, Aime, M, Speranza, F, Cosulich, A, Gallo, A, Marasco, E, Dalla Chiesa, N, Ovadia, M, Scagno, E, Kraus, M, Peroilero, C, Argano, L, Cavalli, A, Di Stefano, D, Kossi, A, Rinaldi, R, Shahaj, E, Lasso, A, Isaa, A, D'Alessandro, G, Barragan, M, Ba, M, Darwish, M, Arcuri, V, Delbono, P, Veronese, P, Tarasenko, V, Costa, E, Parodi, L, de Jesus, M.B, Ouattara, B, Fossa, F, Ladikoff, L, Antonucci, L, Ballerini, A, Choneca, J, Laera, M, Mayizola, J.C.L, Alonzo, G, Ponte di Pino, O, Argano, Lucio, Nijem, N, Larizza, L, Sbarbaro, A, Guano, E, Tcheraghali, A, Tarallo, P, Menghistie, K, Caridi, P, Kumalé, C, Fofi, G, Campanati, E, Ottieri, M.P, Aime, M, Speranza, F, Cosulich, A, Gallo, A, Marasco, E, Dalla Chiesa, N, Ovadia, M, Scagno, E, Kraus, M, Peroilero, C, Argano, L, Cavalli, A, Di Stefano, D, Kossi, A, Rinaldi, R, Shahaj, E, Lasso, A, Isaa, A, D'Alessandro, G, Barragan, M, Ba, M, Darwish, M, Arcuri, V, Delbono, P, Veronese, P, Tarasenko, V, Costa, E, Parodi, L, de Jesus, M.B, Ouattara, B, Fossa, F, Ladikoff, L, Antonucci, L, Ballerini, A, Choneca, J, Laera, M, Mayizola, J.C.L, Alonzo, G, Ponte di Pino, O, and Argano, Lucio

Abstract

Il contributo, così come è strutturato il volume, interpreta la voce "incertezza" alla luce dell'esperienza del Festival Suq di Genova

Published
2023

313. Model-Based Uncertainty in Value Functions

Author

Luis, Carlos E., Bottero, Alessandro G., Vinogradska, Julia, Berkenkamp, Felix, Peters, Jan, Luis, Carlos E., Bottero, Alessandro G., Vinogradska, Julia, Berkenkamp, Felix, and Peters, Jan

Abstract

We consider the problem of quantifying uncertainty over expected cumulative rewards in model-based reinforcement learning. In particular, we focus on characterizing the variance over values induced by a distribution over MDPs. Previous work upper bounds the posterior variance over values by solving a so-called uncertainty Bellman equation, but the over-approximation may result in inefficient exploration. We propose a new uncertainty Bellman equation whose solution converges to the true posterior variance over values and explicitly characterizes the gap in previous work. Moreover, our uncertainty quantification technique is easily integrated into common exploration strategies and scales naturally beyond the tabular setting by using standard deep reinforcement learning architectures. Experiments in difficult exploration tasks, both in tabular and continuous control settings, show that our sharper uncertainty estimates improve sample-efficiency., Comment: AISTATS 2023

Published
2023

314. Impact of beam far side-lobe knowledge in the presence of foregrounds for LiteBIRD

Author

Leloup, C., Patanchon, G., Errard, J., Franceschet, C., Gudmundsson, J. E., Henrot-Versillé, S., Imada, H., Ishino, H., Matsumura, T., Puglisi, G., Wang, W., Adler, A., Aumont, J., Aurlien, R., Baccigalupi, C., Ballardini, M., Banday, A. J., Barreiro, R. B., Bartolo, N., Basyrov, A., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Campeti, P., Carones, A., Carralot, F., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., de Haan, T., De Petris, M., Della Torre, S., Diego-Palazuelos, P., Eriksen, H. K., Finelli, F., Fuskeland, U., Galloni, G., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Génova-Santos, R. T., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Gruppuso, A., Hazumi, M., Hergt, L. T., Herranz, D., Hivon, E., Hoang, T. D., Jost, B., Kohri, K., Krachmalnicoff, N., Lee, A. T., Lembo, M., Levrier, F., Lonappan, A. I., López-Caniego, M., Macias-Perez, J., Martínez-González, E., Masi, S., Matarrese, S., Micheli, S., Monelli, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Namikawa, T., Natoli, P., Novelli, A., Noviello, F., Obata, I., Odagiri, K., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Pavlidou, V., Piacentini, F., Piccirilli, G., Pisano, G., Polenta, G., Raffuzzi, N., Remazeilles, M., Ritacco, A., Rizzieri, A., Ruiz-Granda, M., Sakurai, Y., Shiraishi, M., Stever, S. L., Takase, Y., Tassis, K., Terenzi, L., Thompson, K. L., Tristram, M., Vacher, L., Vielva, P., Wehus, I. K., Weymann-Despres, G., Zannoni, M., Zhou, Y., Leloup, C., Patanchon, G., Errard, J., Franceschet, C., Gudmundsson, J. E., Henrot-Versillé, S., Imada, H., Ishino, H., Matsumura, T., Puglisi, G., Wang, W., Adler, A., Aumont, J., Aurlien, R., Baccigalupi, C., Ballardini, M., Banday, A. J., Barreiro, R. B., Bartolo, N., Basyrov, A., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Campeti, P., Carones, A., Carralot, F., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., de Haan, T., De Petris, M., Della Torre, S., Diego-Palazuelos, P., Eriksen, H. K., Finelli, F., Fuskeland, U., Galloni, G., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Génova-Santos, R. T., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Gruppuso, A., Hazumi, M., Hergt, L. T., Herranz, D., Hivon, E., Hoang, T. D., Jost, B., Kohri, K., Krachmalnicoff, N., Lee, A. T., Lembo, M., Levrier, F., Lonappan, A. I., López-Caniego, M., Macias-Perez, J., Martínez-González, E., Masi, S., Matarrese, S., Micheli, S., Monelli, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Namikawa, T., Natoli, P., Novelli, A., Noviello, F., Obata, I., Odagiri, K., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Pavlidou, V., Piacentini, F., Piccirilli, G., Pisano, G., Polenta, G., Raffuzzi, N., Remazeilles, M., Ritacco, A., Rizzieri, A., Ruiz-Granda, M., Sakurai, Y., Shiraishi, M., Stever, S. L., Takase, Y., Tassis, K., Terenzi, L., Thompson, K. L., Tristram, M., Vacher, L., Vielva, P., Wehus, I. K., Weymann-Despres, G., Zannoni, M., and Zhou, Y.

Abstract

We present a study of the impact of an uncertainty in the beam far side-lobe knowledge on the measurement of the Cosmic Microwave Background $B$-mode signal at large scale. It is expected to be one of the main source of systematic effects in future CMB observations. Because it is crucial for all-sky survey missions to take into account the interplays between beam systematic effects and all the data analysis steps, the primary goal of this paper is to provide the methodology to carry out the end-to-end study of their effect for a space-borne CMB polarization experiment, up to the cosmological results in the form of a bias $\delta r$ on the tensor-to-scalar ratio $r$. LiteBIRD is dedicated to target the measurement of CMB primordial $B$ modes by reaching a sensitivity of $\sigma \left( r \right) \leq 10^{-3}$ assuming $r=0$. As a demonstration of our framework, we derive the relationship between the knowledge of the beam far side-lobes and the tentatively allocated error budget under given assumptions on design, simulation and component separation method. We assume no mitigation of the far side-lobes effect at any stage of the analysis pipeline. We show that $\delta r$ is mostly due to the integrated fractional power difference between the estimated beams and the true beams in the far side-lobes region, with little dependence on the actual shape of the beams, for low enough $\delta r$. Under our set of assumptions, in particular considering the specific foreground cleaning method we used, we find that the integrated fractional power in the far side-lobes should be known at a level as tight as $\sim 10^{-4}$, to achieve the required limit on the bias $\delta r < 1.9 \times 10^{-5}$. The framework and tools developed for this study can be easily adapted to provide requirements under different design, data analysis frameworks and for other future space-borne experiments beyond LiteBIRD.

Published
2023

315. LiteBIRD Science Goals and Forecasts: A full-sky measurement of gravitational lensing of the CMB

Author

Lonappan, A. I., Namikawa, T., Piccirilli, G., Diego-Palazuelos, P., Ruiz-Granda, M., Migliaccio, M., Baccigalupi, C., Bartolo, N., Beck, D., Benabed, K., Challinor, A., Errard, J., Farrens, S., Gruppuso, A., Krachmalnicoff, N., Martínez-González, E., Pettorino, V., Sherwin, B., Starck, J., Vielva, P., Akizawa, R., Anand, A., Aumont, J., Aurlien, R., Azzoni, S., Ballardini, M., Banday, A. J., Barreiro, R. B., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carones, A., Carralot, F., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., De Petris, M., Della Torre, S., Di Giorgi, E., Eriksen, H. K., Finelli, F., Franceschet, C., Fuskeland, U., Galloni, G., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Génova-Santos, R. T., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Hivon, E., Kohri, K., Komatsu, E., Lamagna, L., Lattanzi, M., Leloup, C., Lembo, M., López-Caniego, M., Luzzi, G., Macias-Perez, J., Maffei, B., Masi, S., Massa, M., Matarrese, S., Matsumura, T., Micheli, S., Moggi, A., Monelli, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Nagata, R., Natoli, P., Novelli, A., Obata, I., Occhiuzzi, A., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Pavlidou, V., Piacentini, F., Pinchera, M., Pisano, G., Polenta, G., Puglisi, G., Remazeilles, M., Ritacco, A., Rizzieri, A., Sakurai, Y., Scott, D., Shiraishi, M., Signorelli, G., Stever, S. L., Takase, Y., Tanimura, H., Tartari, A., Tassis, K., Terenzi, L., Tristram, M., Vacher, L., van Tent, B., Wehus, I. K., Weymann-Despres, G., Zannoni, M., Zhou, Y., Lonappan, A. I., Namikawa, T., Piccirilli, G., Diego-Palazuelos, P., Ruiz-Granda, M., Migliaccio, M., Baccigalupi, C., Bartolo, N., Beck, D., Benabed, K., Challinor, A., Errard, J., Farrens, S., Gruppuso, A., Krachmalnicoff, N., Martínez-González, E., Pettorino, V., Sherwin, B., Starck, J., Vielva, P., Akizawa, R., Anand, A., Aumont, J., Aurlien, R., Azzoni, S., Ballardini, M., Banday, A. J., Barreiro, R. B., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carones, A., Carralot, F., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., De Petris, M., Della Torre, S., Di Giorgi, E., Eriksen, H. K., Finelli, F., Franceschet, C., Fuskeland, U., Galloni, G., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Génova-Santos, R. T., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Hivon, E., Kohri, K., Komatsu, E., Lamagna, L., Lattanzi, M., Leloup, C., Lembo, M., López-Caniego, M., Luzzi, G., Macias-Perez, J., Maffei, B., Masi, S., Massa, M., Matarrese, S., Matsumura, T., Micheli, S., Moggi, A., Monelli, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Nagata, R., Natoli, P., Novelli, A., Obata, I., Occhiuzzi, A., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Pavlidou, V., Piacentini, F., Pinchera, M., Pisano, G., Polenta, G., Puglisi, G., Remazeilles, M., Ritacco, A., Rizzieri, A., Sakurai, Y., Scott, D., Shiraishi, M., Signorelli, G., Stever, S. L., Takase, Y., Tanimura, H., Tartari, A., Tassis, K., Terenzi, L., Tristram, M., Vacher, L., van Tent, B., Wehus, I. K., Weymann-Despres, G., Zannoni, M., and Zhou, Y.

Abstract

We explore the capability of measuring lensing signals in $LiteBIRD$ full-sky polarization maps. With a $30$ arcmin beam width and an impressively low polarization noise of $2.16\,\mu$K-arcmin, $LiteBIRD$ will be able to measure the full-sky polarization of the cosmic microwave background (CMB) very precisely. This unique sensitivity also enables the reconstruction of a nearly full-sky lensing map using only polarization data, even considering its limited capability to capture small-scale CMB anisotropies. In this paper, we investigate the ability to construct a full-sky lensing measurement in the presence of Galactic foregrounds, finding that several possible biases from Galactic foregrounds should be negligible after component separation by harmonic-space internal linear combination. We find that the signal-to-noise ratio of the lensing is approximately $40$ using only polarization data measured over $90\%$ of the sky. This achievement is comparable to $Planck$'s recent lensing measurement with both temperature and polarization and represents a four-fold improvement over $Planck$'s polarization-only lensing measurement. The $LiteBIRD$ lensing map will complement the $Planck$ lensing map and provide several opportunities for cross-correlation science, especially in the northern hemisphere.

Published
2023

316. LiteBIRD Science Goals and Forecasts: Improving Sensitivity to Inflationary Gravitational Waves with Multitracer Delensing

Author

Namikawa, T., Lonappan, A. I., Baccigalupi, C., Bartolo, N., Beck, D., Benabed, K., Challinor, A., Diego-Palazuelos, P., Errard, J., Farrens, S., Gruppuso, A., Krachmalnicoff, N., Migliaccio, M., Martínez-González, E., Pettorino, V., Piccirilli, G., Ruiz-Granda, M., Sherwin, B., Starck, J., Vielva, P., Akizawa, R., Anand, A., Aumont, J., Aurlien, R., Azzoni, S., Ballardini, M., Banday, A. J., Barreiro, R. B., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carones, A., Carralot, F., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., de Haan, T., De Petris, M., Della Torre, S., Di Giorgi, E., Eriksen, H. K., Finelli, F., Franceschet, C., Fuskeland, U., Galloni, G., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Hivon, E., Kohri, K., Komatsu, E., Lamagna, L., Lattanzi, M., Leloup, C., Lembo, M., López-Caniego, M., Luzzi, G., Maffei, B., Masi, S., Massa, M., Matarrese, S., Matsumura, T., Micheli, S., Moggi, A., Monelli, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Nagata, R., Natoli, P., Novelli, A., Obata, I., Occhiuzzi, A., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Pavlidou, V., Piacentini, F., Pinchera, M., Pisano, G., Polenta, G., Puglisi, G., Remazeilles, M., Ritacco, A., Rizzieri, A., Rubino-Martin, J., Sakurai, Y., Scott, D., Shiraishi, M., Signorelli, G., Stever, S. L., Takase, Y., Tanimura, H., Tartari, A., Tassis, K., Terenzi, L., Tristram, M., Vacher, L., van Tent, B., Wehus, I. K., Weymann-Despres, G., Zannoni, M., Zhou, Y., Namikawa, T., Lonappan, A. I., Baccigalupi, C., Bartolo, N., Beck, D., Benabed, K., Challinor, A., Diego-Palazuelos, P., Errard, J., Farrens, S., Gruppuso, A., Krachmalnicoff, N., Migliaccio, M., Martínez-González, E., Pettorino, V., Piccirilli, G., Ruiz-Granda, M., Sherwin, B., Starck, J., Vielva, P., Akizawa, R., Anand, A., Aumont, J., Aurlien, R., Azzoni, S., Ballardini, M., Banday, A. J., Barreiro, R. B., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carones, A., Carralot, F., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., de Haan, T., De Petris, M., Della Torre, S., Di Giorgi, E., Eriksen, H. K., Finelli, F., Franceschet, C., Fuskeland, U., Galloni, G., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Hivon, E., Kohri, K., Komatsu, E., Lamagna, L., Lattanzi, M., Leloup, C., Lembo, M., López-Caniego, M., Luzzi, G., Maffei, B., Masi, S., Massa, M., Matarrese, S., Matsumura, T., Micheli, S., Moggi, A., Monelli, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Nagata, R., Natoli, P., Novelli, A., Obata, I., Occhiuzzi, A., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Pavlidou, V., Piacentini, F., Pinchera, M., Pisano, G., Polenta, G., Puglisi, G., Remazeilles, M., Ritacco, A., Rizzieri, A., Rubino-Martin, J., Sakurai, Y., Scott, D., Shiraishi, M., Signorelli, G., Stever, S. L., Takase, Y., Tanimura, H., Tartari, A., Tassis, K., Terenzi, L., Tristram, M., Vacher, L., van Tent, B., Wehus, I. K., Weymann-Despres, G., Zannoni, M., and Zhou, Y.

Abstract

We estimate the efficiency of mitigating the lensing $B$-mode polarization, the so-called delensing, for the $LiteBIRD$ experiment with multiple external data sets of lensing-mass tracers. The current best bound on the tensor-to-scalar ratio, $r$, is limited by lensing rather than Galactic foregrounds. Delensing will be a critical step to improve sensitivity to $r$ as measurements of $r$ become more and more limited by lensing. In this paper, we extend the analysis of the recent $LiteBIRD$ forecast paper to include multiple mass tracers, i.e., the CMB lensing maps from $LiteBIRD$ and CMB-S4-like experiment, cosmic infrared background, and galaxy number density from $Euclid$- and LSST-like survey. We find that multi-tracer delensing will further improve the constraint on $r$ by about $20\%$. In $LiteBIRD$, the residual Galactic foregrounds also significantly contribute to uncertainties of the $B$-modes, and delensing becomes more important if the residual foregrounds are further reduced by an improved component separation method., Comment: 21 pages, 7 figures

Published
2023

317. LiteBIRD Science Goals and Forecasts. A Case Study of the Origin of Primordial Gravitational Waves using Large-Scale CMB Polarization

Author

Campeti, P., Komatsu, E., Baccigalupi, C., Ballardini, M., Bartolo, N., Carones, A., Errard, J., Finelli, F., Flauger, R., Galli, S., Galloni, G., Giardiello, S., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Kohri, K., Leloup, C., Lesgourgues, J., Macias-Perez, J., Martínez-González, E., Matarrese, S., Matsumura, T., Montier, L., Namikawa, T., Paoletti, D., Poletti, D., Remazeilles, M., Shiraishi, M., van Tent, B., Tristram, M., Vacher, L., Vittorio, N., Weymann-Despres, G., Anand, A., Aumont, J., Aurlien, R., Banday, A. J., Barreiro, R. B., Basyrov, A., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Carralot, F., Casas, F. J., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., De Petris, M., Della Torre, S., Di Giorgi, E., Diego-Palazuelos, P., Eriksen, H. K., Franceschet, C., Fuskeland, U., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Ghigna, T., Gimeno-Amo, C., Gjerløw, E., Gruppuso, A., Gudmundsson, J., Krachmalnicoff, N., Lamagna, L., Lattanzi, M., Lembo, M., Lonappan, A. I., Masi, S., Massa, M., Micheli, S., Moggi, A., Monelli, M., Morgante, G., Mot, B., Mousset, L., Nagata, R., Natoli, P., Novelli, A., Obata, I., Pagano, L., Paiella, A., Pavlidou, V., Piacentini, F., Pinchera, M., Pisano, G., Puglisi, G., Raffuzzi, N., Ritacco, A., Rizzieri, A., Ruiz-Granda, M., Savini, G., Scott, D., Signorelli, G., Stever, S. L., Stutzer, N., Sullivan, R. M., Tartari, A., Tassis, K., Terenzi, L., Thompson, K. L., Vielva, P., Wehus, I. K., Zhou, Y., Campeti, P., Komatsu, E., Baccigalupi, C., Ballardini, M., Bartolo, N., Carones, A., Errard, J., Finelli, F., Flauger, R., Galli, S., Galloni, G., Giardiello, S., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Kohri, K., Leloup, C., Lesgourgues, J., Macias-Perez, J., Martínez-González, E., Matarrese, S., Matsumura, T., Montier, L., Namikawa, T., Paoletti, D., Poletti, D., Remazeilles, M., Shiraishi, M., van Tent, B., Tristram, M., Vacher, L., Vittorio, N., Weymann-Despres, G., Anand, A., Aumont, J., Aurlien, R., Banday, A. J., Barreiro, R. B., Basyrov, A., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Carralot, F., Casas, F. J., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., De Petris, M., Della Torre, S., Di Giorgi, E., Diego-Palazuelos, P., Eriksen, H. K., Franceschet, C., Fuskeland, U., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Ghigna, T., Gimeno-Amo, C., Gjerløw, E., Gruppuso, A., Gudmundsson, J., Krachmalnicoff, N., Lamagna, L., Lattanzi, M., Lembo, M., Lonappan, A. I., Masi, S., Massa, M., Micheli, S., Moggi, A., Monelli, M., Morgante, G., Mot, B., Mousset, L., Nagata, R., Natoli, P., Novelli, A., Obata, I., Pagano, L., Paiella, A., Pavlidou, V., Piacentini, F., Pinchera, M., Pisano, G., Puglisi, G., Raffuzzi, N., Ritacco, A., Rizzieri, A., Ruiz-Granda, M., Savini, G., Scott, D., Signorelli, G., Stever, S. L., Stutzer, N., Sullivan, R. M., Tartari, A., Tassis, K., Terenzi, L., Thompson, K. L., Vielva, P., Wehus, I. K., and Zhou, Y.

Abstract

We study the possibility of using the $LiteBIRD$ satellite $B$-mode survey to constrain models of inflation producing specific features in CMB angular power spectra. We explore a particular model example, i.e. spectator axion-SU(2) gauge field inflation. This model can source parity-violating gravitational waves from the amplification of gauge field fluctuations driven by a pseudoscalar "axionlike" field, rolling for a few e-folds during inflation. The sourced gravitational waves can exceed the vacuum contribution at reionization bump scales by about an order of magnitude and can be comparable to the vacuum contribution at recombination bump scales. We argue that a satellite mission with full sky coverage and access to the reionization bump scales is necessary to understand the origin of the primordial gravitational wave signal and distinguish among two production mechanisms: quantum vacuum fluctuations of spacetime and matter sources during inflation. We present the expected constraints on model parameters from $LiteBIRD$ satellite simulations, which complement and expand previous studies in the literature. We find that $LiteBIRD$ will be able to exclude with high significance standard single-field slow-roll models, such as the Starobinsky model, if the true model is the axion-SU(2) model with a feature at CMB scales. We further investigate the possibility of using the parity-violating signature of the model, such as the $TB$ and $EB$ angular power spectra, to disentangle it from the standard single-field slow-roll scenario. We find that most of the discriminating power of $LiteBIRD$ will reside in $BB$ angular power spectra rather than in $TB$ and $EB$ correlations., Comment: 22 pages, 13 figures. Submitted to JCAP

Published
2023

318. Measuring the CMB primordial B-modes with Bolometric Interferometry

Author

Mennella, A., Ade, P., Almela, A., Amico, G., Arnaldi, L. H., Aumont, J., Banfi, S., Battistelli, E. S., Bélier, B., Bergé, L., Bernard, J. -Ph., de Bernardis, P., Bersanelli, M., Bonaparte, J., Bonilla, J. D., Bunn, E., Buzi, D., Cacciotti, F., Camilieri, D., Cavaliere, F., Chanial, P., Chapron, C., Colombo, L., Columbro, F., Coppolecchia, A., Costanza, M. B., D'Alessandro, G., De Gasperis, G., De Leo, M., De Petris, M., Del Castillo, N., Dheilly, S., Etchegoyen, A., Ferazzoli, S., Ferreyro, L. P., Franceschet, C., Lerena, M. M. Gamboa, Ganga, K., García, B., Redondo, M. E. García, Gayer, D., Geria, J. M., Gervasi, M., Giard, M., Gilles, V., Berisso, M. Gómez, Gonzalez, M., Gradziel, M., Grandsire, L., Hamilton, J. -Ch., Hampel, M. R., Isopi, G., Kaplan, J., Lamagna, L., Lazarte, F., Loucatos, S., Maffei, B., Mancilla, A., Mandelli, S., Manzan, E., Marchitelli, E., Marnieros, S., Marty, W., Masi, S., May, A., Maya, J., McCulloch, M., Mele, L., Melo, D., Mirón-Granese, N., Montier, L., Mousset, L., Müller, N., Nati, F., O'Sullivan, C., Paiella, A., Pajot, F., Paradiso, S., Pascale, E., Passerini, A., Pelosi, A., Perciballi, M., Pezzotta, F., Piacentini, F., Piat, M., Piccirillo, L., Pisano, G., Platino, M., Polenta, G., Prêle, D., Rambaud, D., Ramos, G., Rasztocky, E., Régnier, M., Reyes, C., Rodríguez, F., Rodríguez, C. A., Romero, G. E., Salum, J. M., Schillaci, A., Scóccola, C., Stankowiak, G., Tartari, A., Thermeau, J. -P., Timbie, P., Tomasi, M., Torchinsky, S., Tucker, G., Tucker, C., Vacher, L., Voisin, F., Wright, M., Zannoni, M., Zullo, A., Mennella, A., Ade, P., Almela, A., Amico, G., Arnaldi, L. H., Aumont, J., Banfi, S., Battistelli, E. S., Bélier, B., Bergé, L., Bernard, J. -Ph., de Bernardis, P., Bersanelli, M., Bonaparte, J., Bonilla, J. D., Bunn, E., Buzi, D., Cacciotti, F., Camilieri, D., Cavaliere, F., Chanial, P., Chapron, C., Colombo, L., Columbro, F., Coppolecchia, A., Costanza, M. B., D'Alessandro, G., De Gasperis, G., De Leo, M., De Petris, M., Del Castillo, N., Dheilly, S., Etchegoyen, A., Ferazzoli, S., Ferreyro, L. P., Franceschet, C., Lerena, M. M. Gamboa, Ganga, K., García, B., Redondo, M. E. García, Gayer, D., Geria, J. M., Gervasi, M., Giard, M., Gilles, V., Berisso, M. Gómez, Gonzalez, M., Gradziel, M., Grandsire, L., Hamilton, J. -Ch., Hampel, M. R., Isopi, G., Kaplan, J., Lamagna, L., Lazarte, F., Loucatos, S., Maffei, B., Mancilla, A., Mandelli, S., Manzan, E., Marchitelli, E., Marnieros, S., Marty, W., Masi, S., May, A., Maya, J., McCulloch, M., Mele, L., Melo, D., Mirón-Granese, N., Montier, L., Mousset, L., Müller, N., Nati, F., O'Sullivan, C., Paiella, A., Pajot, F., Paradiso, S., Pascale, E., Passerini, A., Pelosi, A., Perciballi, M., Pezzotta, F., Piacentini, F., Piat, M., Piccirillo, L., Pisano, G., Platino, M., Polenta, G., Prêle, D., Rambaud, D., Ramos, G., Rasztocky, E., Régnier, M., Reyes, C., Rodríguez, F., Rodríguez, C. A., Romero, G. E., Salum, J. M., Schillaci, A., Scóccola, C., Stankowiak, G., Tartari, A., Thermeau, J. -P., Timbie, P., Tomasi, M., Torchinsky, S., Tucker, G., Tucker, C., Vacher, L., Voisin, F., Wright, M., Zannoni, M., and Zullo, A.

Abstract

The Q&U Bolometric Interferometer for Cosmology (QUBIC) is the first bolometric interferometer designed to measure the primordial B-mode polarization of the Cosmic Microwave Background (CMB). Bolometric interferometry is a novel technique that combines the sensitivity of bolometric detectors with the control of systematic effects that is typical of interferometry, both key features in the quest for the faint signal of the primordial B-modes. A unique feature is the so-called "spectral imaging", i.e., the ability to recover the sky signal in several sub-bands within the physical band during data analysis. This feature provides an in-band spectral resolution of \Delta{\nu}/{\nu} \sim 0.04 that is unattainable by a traditional imager. This is a key tool for controlling the Galactic foregrounds contamination. In this paper, we describe the principles of bolometric interferometry, the current status of the QUBIC experiment and future prospects., Comment: To appear in Proc. of the mm Universe 2023 conference, Grenoble (France), June 2023, published by F. Mayet et al. (Eds), EPJ Web of conferences, EDP Sciences

Published
2023

319. The advantage of Bolometric Interferometry for controlling Galactic foreground contamination in CMB primordial B-modes measurements

Author

Manzan, E., Regnier, M., Hamilton, J-Ch., Mennella, A., Errard, J., Zapelli, L., Torchinsky, S. A., Paradiso, S., Battistelli, E., Bersanelli, M., De Bernardis, P., De Petris, M., D'Alessandro, G., Gervasi, M., Masi, S., Piat, M., Rasztocky, E., Romero, G. E, Scoccola, C. G., Zannoni, M., Collaboration, the QUBIC, Manzan, E., Regnier, M., Hamilton, J-Ch., Mennella, A., Errard, J., Zapelli, L., Torchinsky, S. A., Paradiso, S., Battistelli, E., Bersanelli, M., De Bernardis, P., De Petris, M., D'Alessandro, G., Gervasi, M., Masi, S., Piat, M., Rasztocky, E., Romero, G. E, Scoccola, C. G., Zannoni, M., and Collaboration, the QUBIC

Abstract

In the quest for the faint primordial B-mode polarization of the Cosmic Microwave Background, three are the key requirements for any present or future experiment: an utmost sensitivity, excellent control over instrumental systematic effects and over Galactic foreground contamination. Bolometric Interferometry (BI) is a novel technique that matches them all by combining the sensitivity of bolometric detectors, the control of instrumental systematics from interferometry and a software-based, tunable, in-band spectral resolution due to its ability to perform band-splitting during data analysis (spectral imaging). In this paper, we investigate how the spectral imaging capability of BI can help in detecting residual contamination in case an over-simplified model of foreground emission is assumed in the analysis. To mimic this situation, we focus on the next generation of ground-based CMB experiment, CMB-S4, and compare its anticipated sensitivities, frequency and sky coverage with a hypothetical version of the same experiment based on BI, CMB-S4/BI, assuming that line-of-sight (LOS) frequency decorrelation is present in dust emission but is not accounted for during component separation. We show results from a Monte-Carlo analysis based on a parametric component separation method (FGBuster), highlighting how BI has the potential to diagnose the presence of foreground residuals in estimates of the tensor-to-scalar ratio $r$ in the case of unaccounted Galactic dust LOS frequency decorrelation., Comment: To appear in Proc. of the mm Universe 2023 conference, Grenoble (France), June 2023, published by F. Mayet et al. (Eds), EPJ Web of conferences, EDP Sciences

Published
2023

320. Observing galaxy clusters and the cosmic web through the Sunyaev Zel'dovich effect with MISTRAL

Author

Battistelli, E. S., Barbavara, E., de Bernardis, P., Cacciotti, F., Capalbo, V., Carbone, A., Carretti, E., Ciccalotti, D., Columbro, F., Coppolecchia, A., Cruciani, A., D'Alessandro, G., De Petris, M., Govoni, F., Isopi, G., Lamagna, L., Levati, E., Marongiu, P., Mascia, A., Masi, S., Molinari, E., Murgia, M., Navarrini, A., Novelli, A., Occhiuzzi, A., Orlati, A., Pappalardo, E., Paiella, A., Pettinari, G., Piacentini, F., Pisanu, T., Poppi, S., Porceddu, I., Ritacco, A., Schirru, M. R., Vargiu, G. P., Battistelli, E. S., Barbavara, E., de Bernardis, P., Cacciotti, F., Capalbo, V., Carbone, A., Carretti, E., Ciccalotti, D., Columbro, F., Coppolecchia, A., Cruciani, A., D'Alessandro, G., De Petris, M., Govoni, F., Isopi, G., Lamagna, L., Levati, E., Marongiu, P., Mascia, A., Masi, S., Molinari, E., Murgia, M., Navarrini, A., Novelli, A., Occhiuzzi, A., Orlati, A., Pappalardo, E., Paiella, A., Pettinari, G., Piacentini, F., Pisanu, T., Poppi, S., Porceddu, I., Ritacco, A., Schirru, M. R., and Vargiu, G. P.

Abstract

Galaxy clusters and surrounding medium, can be studied using X-ray bremsstrahlung emission and Sunyaev Zel'dovich (SZ) effect. Both astrophysical probes, sample the same environment with different parameters dependance. The SZ effect is relatively more sensitive in low density environments and thus is useful to study the filamentary structures of the cosmic web. In addition, observations of the matter distribution require high angular resolution in order to be able to map the matter distribution within and around galaxy clusters. MISTRAL is a camera working at 90GHz which, once coupled to the Sardinia Radio Telescope, can reach $12''$ angular resolution over $4'$ field of view (f.o.v.). The forecasted sensitivity is $NEFD \simeq 10-15mJy \sqrt{s}$ and the mapping speed is $MS= 380'^{2}/mJy^{2}/h$. MISTRAL was recently installed at the focus of the SRT and soon will take its first photons., Comment: To appear in Proc. of the mm Universe 2023 conference, Grenoble (France), June 2023, published by F. Mayet et al. (Eds), EPJ Web of conferences, EDP Sciences

Published
2023

321. Model-Based Epistemic Variance of Values for Risk-Aware Policy Optimization

Author

Luis, Carlos E., Bottero, Alessandro G., Vinogradska, Julia, Berkenkamp, Felix, Peters, Jan, Luis, Carlos E., Bottero, Alessandro G., Vinogradska, Julia, Berkenkamp, Felix, and Peters, Jan

Abstract

We consider the problem of quantifying uncertainty over expected cumulative rewards in model-based reinforcement learning. In particular, we focus on characterizing the variance over values induced by a distribution over MDPs. Previous work upper bounds the posterior variance over values by solving a so-called uncertainty Bellman equation (UBE), but the over-approximation may result in inefficient exploration. We propose a new UBE whose solution converges to the true posterior variance over values and leads to lower regret in tabular exploration problems. We identify challenges to apply the UBE theory beyond tabular problems and propose a suitable approximation. Based on this approximation, we introduce a general-purpose policy optimization algorithm, Q-Uncertainty Soft Actor-Critic (QU-SAC), that can be applied for either risk-seeking or risk-averse policy optimization with minimal changes. Experiments in both online and offline RL demonstrate improved performance compared to other uncertainty estimation methods., Comment: arXiv admin note: substantial text overlap with arXiv:2302.12526

Published
2023

322. Value-Distributional Model-Based Reinforcement Learning

Author

Luis, Carlos E., Bottero, Alessandro G., Vinogradska, Julia, Berkenkamp, Felix, Peters, Jan, Luis, Carlos E., Bottero, Alessandro G., Vinogradska, Julia, Berkenkamp, Felix, and Peters, Jan

Abstract

Quantifying uncertainty about a policy's long-term performance is important to solve sequential decision-making tasks. We study the problem from a model-based Bayesian reinforcement learning perspective, where the goal is to learn the posterior distribution over value functions induced by parameter (epistemic) uncertainty of the Markov decision process. Previous work restricts the analysis to a few moments of the distribution over values or imposes a particular distribution shape, e.g., Gaussians. Inspired by distributional reinforcement learning, we introduce a Bellman operator whose fixed-point is the value distribution function. Based on our theory, we propose Epistemic Quantile-Regression (EQR), a model-based algorithm that learns a value distribution function that can be used for policy optimization. Evaluation across several continuous-control tasks shows performance benefits with respect to established model-based and model-free algorithms.

Published
2023

323. A Pragmatic Theory of Computational Artefacts.

Author

Buda, Alessandro G. and Primiero, Giuseppe

Subjects
*COMPUTER software development, *PRAGMATICS, *THEORY of knowledge, *ONTOLOGY
Abstract

Some computational phenomena rely essentially on pragmatic considerations, and seem to undermine the independence of the specification from the implementation. These include software development, deviant uses, esoteric languages and recent data-driven applications. To account for them, the interaction between pragmatics, epistemology and ontology in computational artefacts seems essential, indicating the need to recover the role of the language metaphor. We propose a User Levels (ULs) structure as a pragmatic complement to the Levels of Abstraction (LoAs)-based structure defining the ontology and epistemology of computational artefacts. ULs identify a flexible hierarchy in which users bear their own semantic and normative requirements, possibly competing with the logical specification. We formulate a notion of computational act intended in its pragmatic sense, alongside pragmatic versions of implementation and correctness. [ABSTRACT FROM AUTHOR]

Published
2024
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324. Lung clearance index short-term variability in cystic fibrosis: a pre-post pulmonary exacerbation study.

Author

De Marchis, Matteo, Montemitro, Enza, Boni, Alessandra, Federici, Alessandra, Di Giovanni, Daniele, Cristiani, Luca, Cutrera, Renato, and Fiocchi, Alessandro G.

Subjects
INTRAVENOUS therapy, CHILDREN'S hospitals, PATIENTS, QUANTITATIVE research, CYSTIC fibrosis, HOSPITAL admission & discharge, PRE-tests & post-tests, VITAL capacity (Respiration), HOSPITAL wards, DESCRIPTIVE statistics, FORCED expiratory volume, RESEARCH funding, RESPIRATION, SPIROMETRY, ANTIBIOTICS, DISEASE exacerbation, HOSPITAL care of children, EVALUATION
Abstract

Background: Multiple Breath washout (MBW) represents an important tool to detect early a possible pulmonary exacerbation especially in Cystic Fibrosis (CF) disease. Lung clearance index (LCI) is the most commonly reported multiple breath washout (MBW) index and in the last years was used as management measure for evaluation. Our aim was to analyze clinical utility of LCI index variability in pulmonary exacerbation in CF after intravenous (IV) antibiotic therapy. Methods: A single-center study was conducted at CF Unit of Bambino Gesù Children's Hospital among hospitalized > 3 years patients for pulmonary exacerbations and treated with antibiotic IV treatment for 14 days. MBW and spirometry were evaluated within 72 h of admission to hospital and at the end of hospitalization. Descriptive analysis was conducted and correlations between quantitative variables were investigated. Results: Fifty-seven patients (M22/F35) with an average age 18.56 (± 8.54) years were enrolled. LCI2.5 was significantly reduced at the end of antibiotic treatment in both pediatric and adult populations with an average reduction of -6,99%; 37/57 patients denoted an improvement, 20/57 are stable or worsened in LCI2.5 values and 4/57 (7.02%) had a significant deterioration (> 15%) at end of treatment. On the contrary a significative elevation of FEV1 and FVC were found, respectively of + 7,30% and of + 5,46%. A positive good correlection among LCI 2.5 and Scond (rho = + 0,615, p = 0.000) and LCI 2.5 and Sacin (rho = + 0,649, p = 0.000) and a negative strong correlation between FEV1 and LCI 2.5 were found in post treatment period. A similar modification of LCI 2.5 and FEV1 was noticed in both adult and pediatric population. Conclusions: LCI may have a role in the routine clinical care of both adult and pediatric CF patients as a good tool to assess response to IV antibiotic end-therapy in the same way as FEV1. [ABSTRACT FROM AUTHOR]

Published
2024
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325. Assessment of long-term safety and efficacy of dupilumab in children with asthma (LIBERTY ASTHMA EXCURSION): an open-label extension study.

Author

Bacharier, Leonard B, Maspero, Jorge F, Katelaris, Constance H, Fiocchi, Alessandro G, Gagnon, Remi, de Mir, Ines, Guilbert, Theresa W, Jackson, Daniel J, Staudinger, Heribert W, Laws, Elizabeth, Mannent, Leda P, Akinlade, Bolanle, Maloney, Jennifer, Tawo, Kelsey, Khokhar, Faisal A, Li, Ning, Hardin, Megan, Abdulai, Raolat M, Lederer, David J, and Robinson, Lacey B

Subjects
DUPILUMAB, ASTHMA in children, RESPIRATORY infections, PATIENT experience, SUBCUTANEOUS injections
Abstract

Dupilumab efficacy and safety in children aged 6–11 years with uncontrolled, moderate-to-severe asthma were shown in the VOYAGE study—a 52-week, multinational, multicentre, phase 3 randomised, double-blind, placebo-controlled trial. We aimed to evaluate the long-term safety and efficacy of dupilumab in children with moderate-to-severe asthma who previously participated in the VOYAGE study. 365 of 408 children with moderate-to-severe asthma from VOYAGE enrolled in EXCURSION, a 52 week, open-label extension study conducted at 70 centres across 17 countries. 240 children continued with add-on dupilumab (dosed according to bodyweight: 100 mg for those weighing ≤30 kg and 200 mg for those weighing more than 30 kg at EXCURSION baseline) once every 2 weeks administered by subcutaneous injection (dupilumab/dupilumab group) and 125 children on placebo during VOYAGE initiated dupilumab (100 or 200 mg, according to bodyweight), once every 2 weeks administered by subcutaneous injection (placebo/dupilumab group). Following a protocol amendment, for a subset of children weighing 30 kg or less, the dose was changed to 300 mg once every 4 weeks. The primary endpoint for the open-label extension study was the number and proportion of patients with any treatment-emergent adverse event (TEAE) during the 52-week study period in the overall population (defined as children aged 6–11 years old with moderate-to-severe asthma who previously completed VOYAGE). Statistical analyses were descriptive. This study is registered with ClinicalTrials.gov (NCT03560466 ; EXCURSION). Children who completed VOYAGE were eligible to enrol in EXCURSION between June 21, 2018 and Aug 18, 2020. During EXCURSION, the safety profile and proportion of patients reporting TEAEs were consistent with those observed during the parent study (VOYAGE). In the overall population, 232 (63·6%) of 365 patients experienced at least one TEAE (dupilumab/dupilumab: 147 [61·3%]; placebo/dupilumab: 85 [68·0%]). The most frequently reported TEAEs were nasopharyngitis, pharyngitis, and upper respiratory tract infections. In EXCURSION, long-term treatment with dupilumab was well tolerated with an acceptable safety profile. Sanofi and Regeneron Pharmaceuticals. [ABSTRACT FROM AUTHOR]

Published
2024
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327. Wehinne »und da« – Zur erlebten Rede in der Hebräischen Bibel.

Author

Casagrande, Alessandro G. K.

Subjects
*FREEDOM of speech, *HEBREW literature, *OBJECTIONS (Evidence), *POSSIBILITY, *DISCOURSE, *NARRATIVES
Abstract

Frequently it has been pointed out that in Biblical Hebrew literature the narrator tends to be less overt. Nonetheless, this has seldom been substantiated with the narrative mode as an analytical category. The latter especially applies to the representation of speech. Herein, it is debated, if besides direct and indirect speech also free indirect discourse may be attested in the Hebrew Bible. Cynthia L. Miller has denied this possibility, which has been notably advocated by Meir Sternberg. However, using a linguistically substantiated narrative analysis Miller's objections can be called into question. This justifies the fundamental possibility of free indirect discourse with wehinne -phrases. [ABSTRACT FROM AUTHOR]

Published
2023
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328. Potential of Reinoculation Using R. tropici Applied under Cover to Increase Bean Yield.

Author

Lourenço, Amanda E., Teixeira, Itamar R., Rocha, Ednaldo C., Silva, Gisele C., Reis, Elton F., Santos, Fenelon L., Silva, Guilherme R., Lisboa, Cristiane F., Kikuti, Hamilton, and Silva, Alessandro G.

Abstract

The common bean is known to require nitrogen, with mineral fertilizer being the main form of supply to the plants. However, more efficient inoculants containing strains of Rhizobium tropici that are potentially more efficient in fixing atmospheric N2 could replace the use of nitrogen fertilizers as long as some of the existing challenges in the application methodology are overcome (for example, ensuring the existence of active nodules in the most demanding crop phases: flowering and grain filling). This study aimed to verify the responses of common bean plants subjected to reinoculation using Rhizobium tropici in topdressing applied at different stages in a greenhouse and in a field between March and April 2020 and in the spring–summer harvest of 2020/2021, respectively. A randomized block design was used, along with four replications: T1 = uninoculated control; T2 = inoculation via seed (VS); T3 = VS + reinoculation at the V4 stage; T4 = VS + reinoculation at the R5 stage; T5 = VS + reinoculation at the R6 stage; T6 = VS + reinoculation at the V4 and R5 stages; T7 = VS + reinoculation at the V4 and R6 stages; T8 = VS + reinoculation at the R5 and R6 stages; T9 = VS + reinoculation at the V4, R5, and R6 stages; and T10 = mineral nitrogen fertilization. Nodulation and morphological variables were evaluated at the R7 stage, and agronomic variables were evaluated at the R9 stage at harvest. The use of reinoculation, in addition to inoculation, positively influenced the bean nodulation process. The morphological characteristics of the plants showed good development with the supply of N (carried out via inoculation and reinoculation), equivalent to the development that could be achieved via the addition of a mineral nitrogen fertilizer. Reinoculation from the R5 to R7 stages proved ineffective in supplying N to the common bean crop. Inoculation in the seed associated with reinoculation in coverage at the V4 stage provided higher yields (3.271 kg ha−1), reinforcing the potential for mineral nitrogen fertilizers to be replaced. The use of the seed inoculation technique with subsequent reinoculation under cover can completely replace the use of nitrogenous mineral fertilizers in fertilizing bean plants, making the cultivation of this fabacea more sustainable in terms of the associated costs and environmental problems. [ABSTRACT FROM AUTHOR]

Published
2023
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335. QUBIC – The Q & U Bolometric Interferometer for Cosmology

Author

O’Sullivan, C., primary, Burke, D., additional, De Petris, M., additional, Gradziel, M., additional, Hamilton, J.-Ch., additional, Torchinsky, S., additional, Scully, S., additional, Wright, M., additional, Ade, P., additional, Almela, A., additional, Amico, G., additional, Arnaldi, L. H., additional, Aumont, J., additional, Banfi, S., additional, Battistelli, E.S., additional, Bélier, B., additional, Bergé, L., additional, Bernard, J.-Ph., additional, Bersanelli, M., additional, Bonaparte, J., additional, Bonilla, J.D., additional, Bunn, E., additional, Buzi, D., additional, Camilieri, D., additional, Cavaliere, F., additional, Chanial, P., additional, Chapron, C., additional, Colombo, S., additional, Columbro, F., additional, Coppolecchia, A., additional, Costanza, M.B., additional, D’Alessandro, G., additional, de Bernardis, P., additional, De Gasperis, G., additional, De Leo, M., additional, Del Castillo, N., additional, Dheilly, S., additional, Etchegoyen, A., additional, Famá, M., additional, Ferreyro, L.P., additional, Franceschet, C., additional, Lerena, M.M. Gamboa, additional, Ganga, K.M., additional, García, B., additional, García Redondo, M.E., additional, Gayer, D., additional, Geria, J.M., additional, Gervasi, M., additional, Giard, M., additional, Gilles, V., additional, Gómez Berisso, M., additional, González, M., additional, Grandsire, L., additional, Hampel, M.R., additional, Isopi, G., additional, Kaplan, J., additional, Kristukat, C., additional, Lamagna, L., additional, Lazarte, F., additional, Loucatos, S., additional, Mancilla, A., additional, Mandelli, D., additional, Manzan, E., additional, Marnieros, S., additional, Marty, W., additional, Masi, S., additional, May, A., additional, Maya, J., additional, McCulloch, M., additional, Mele, L., additional, Melo, D., additional, Mennella, A., additional, Mirón-Granese, N., additional, Montier, L., additional, Mousset, L., additional, Müller, N., additional, Murphy, J.D., additional, Nati, F., additional, Paiella, A., additional, Pajot, F., additional, Paradiso, S., additional, Passerini, A., additional, Pelosi, A., additional, Perciballi, M., additional, Pezzotta, F., additional, Piacentini, F., additional, Piat, M., additional, Piccirillo, L., additional, Pisano, G., additional, Platino, M., additional, Polenta, G., additional, Prêle, D., additional, Rambaud, D., additional, Ramos, G., additional, Rasztocky, E., additional, Régnier, M., additional, Reyes, C., additional, Rodríguez, F., additional, Rodríguez, C.A., additional, Romero, G. E., additional, Salum, J.M., additional, Schillaci, A., additional, Scóccola, C., additional, Stankowiak, G., additional, Supanitsky, A.D., additional, Taboada, A., additional, Tartari, A., additional, Thermeau, J.-P., additional, Timbie, P., additional, Tucker, G., additional, Tucker, C., additional, Vacher, L., additional, Voisin, F., additional, Zannoni, M., additional, and Zullo, A., additional

Published
2023
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338. Science and Innovation with Stratospheric Balloons: The Olimpo & Lspe/Swipe Projects

Author

Volpe, A., primary, Albano, M., additional, Ade, P. A. R., additional, Baldini, A. M., additional, Baù, A., additional, Battistelli, E., additional, de Bernardis, P., additional, Biasotti, M., additional, Boscaleri, A., additional, Cei, F., additional, Colantoni, I., additional, Columbro, F., additional, Coppi, G., additional, Coppolecchia, A., additional, D’Alessandro, G., additional, De Petris, M., additional, Fafone, V., additional, Fontanelli, F., additional, Gervasi, M., additional, Galli, L., additional, Gatti, F., additional, Grosso, D., additional, Lamagna, L., additional, Magneville, C., additional, Masi, S., additional, Mauskopf, P., additional, May, A., additional, Mele, L., additional, Paiella, A., additional, Pettinari, G., additional, Passerini, A., additional, Piacentini, F., additional, Piccirillo, L., additional, Pisano, G., additional, Polenta, G., additional, Presta, G., additional, Schillaci, A., additional, Signorelli, G., additional, Siri, B., additional, Spinella, F., additional, Tartari, A., additional, Tommasi, E., additional, Tucker, C., additional, Vaccaro, D., additional, Vdovin, V. F., additional, Zannoni, M., additional, and Yvon, D., additional

Published
2023
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339. COVID-19 and Pulmonary Angiogenesis: The Possible Role of Hypoxia and Hyperinflammation in the Overexpression of Proteins Involved in Alveolar Vascular Dysfunction

Author

Miggiolaro, Anna Flavia Ribeiro Santos, primary, da Silva, Felipe Paes Gomes, additional, Wiedmer, David Batista, additional, Godoy, Thiago Mateus, additional, Borges, Nicolas Henrique, additional, Piper, Giulia Werner, additional, Oricil, Alessandro G. G., additional, Klein, Carolline Konzen, additional, Hlatchuk, Elisa Carolina, additional, Dagostini, Júlio César H., additional, Collete, Mariana, additional, Arantes, Mayara Pezzini, additional, D’Amico, Raissa C., additional, Dutra, Anderson A., additional, de Azevedo, Marina Luise Viola, additional, and de Noronha, Lucia, additional

Published
2023
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340. Blood Cells Count Derived Inflammation Indexes as Predictors of Early Treatment Response to Dupilumab in Patients with Moderate-to-Severe Atopic Dermatitis

Author

Zinellu, Angelo, primary, Sucato, Federica, additional, Piras, Viviana, additional, Addis, Gian Mario, additional, Biondi, Gabriele, additional, Montesu, Maria Antonia, additional, Mangoni, Arduino A., additional, Carru, Ciriaco, additional, Pirina, Pietro, additional, Paliogiannis, Panagiotis, additional, Fois, Alessandro G., additional, and Satta, Rosanna, additional

Published
2023
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342. Assessment of the long-term safety and efficacy of dupilumab in children with asthma: LIBERTY ASTHMA EXCURSION

Author

Bacharier, Leonard B., additional, Maspero, Jorge F., additional, Katelaris, Constance H., additional, Fiocchi, Alessandro G., additional, Gagnon, Remi, additional, de Mir-Messa, Ines, additional, Guilbert, Theresa W., additional, Jackson, Daniel J., additional, Eckard, Hamelmann, additional, Li, Ning, additional, Akinlade, Bolanle, additional, Laws, Elizabeth, additional, Mannent, Leda P., additional, Maloney, Jennifer, additional, Tawo, Kelsey T., additional, Khokhar, Faisal A., additional, Hardin, Megan, additional, Abdulai, Raolat M, additional, Lederer, David J., additional, and Robinson, Lacey B., additional

Published
2023
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348. COVID-19 and Pulmonary Angiogenesis: The Possible Role of Hypoxia and Hyperinflammation in the Overexpression of Proteins Involved in Alveolar Vascular Dysfunction

Author

Anna Flavia Ribeiro Santos Miggiolaro, Felipe Paes Gomes da Silva, David Batista Wiedmer, Thiago Mateus Godoy, Nicolas Henrique Borges, Giulia Werner Piper, Alessandro G. G. Oricil, Carolline Konzen Klein, Elisa Carolina Hlatchuk, Júlio César H. Dagostini, Mariana Collete, Mayara Pezzini Arantes, Raissa C. D’Amico, Anderson A. Dutra, Marina Luise Viola de Azevedo, and Lucia de Noronha

Subjects
Infectious Diseases, SARS-CoV-2, endothelial dysfunction, angiogenesis, microthrombi, immunohistochemistry, Virology
Abstract

COVID-19 has been considered a vascular disease, and inflammation, intravascular coagulation, and consequent thrombosis may be associated with endothelial dysfunction. These changes, in addition to hypoxia, may be responsible for pathological angiogenesis. This research investigated the impact of COVID-19 on vascular function by analyzing post-mortem lung samples from 24 COVID-19 patients, 10 H1N1pdm09 patients, and 11 controls. We evaluated, through the immunohistochemistry technique, the tissue immunoexpressions of biomarkers involved in endothelial dysfunction, microthrombosis, and angiogenesis (ICAM-1, ANGPT-2, and IL-6, IL-1β, vWF, PAI-1, CTNNB-1, GJA-1, VEGF, VEGFR-1, NF-kB, TNF-α and HIF-1α), along with the histopathological presence of microthrombosis, endothelial activation, and vascular layer hypertrophy. Clinical data from patients were also observed. The results showed that COVID-19 was associated with increased immunoexpression of biomarkers involved in endothelial dysfunction, microthrombosis, and angiogenesis compared to the H1N1 and CONTROL groups. Microthrombosis and vascular layer hypertrophy were found to be more prevalent in COVID-19 patients. This study concluded that immunothrombosis and angiogenesis might play a key role in COVID-19 progression and outcome, particularly in patients who die from the disease.

Published
2023
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349. Assessment of the long-term safety and efficacy of dupilumab in children with asthma: LIBERTY ASTHMA EXCURSION

Author

Leonard B. Bacharier, Jorge F. Maspero, Constance H. Katelaris, Alessandro G. Fiocchi, Remi Gagnon, Ines de Mir-Messa, Theresa W. Guilbert, Daniel J. Jackson, Hamelmann Eckard, Ning Li, Bolanle Akinlade, Elizabeth Laws, Leda P. Mannent, Jennifer Maloney, Kelsey T. Tawo, Faisal A. Khokhar, Megan Hardin, Raolat M Abdulai, David J. Lederer, and Lacey B. Robinson

Published
2023
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350. The Presence of Cholesteryl Ester Transfer Protein (CETP) in Endothelial Cells Generates Vascular Oxidative Stress and Endothelial Dysfunction

Author

Amarylis C. B. A. Wanschel, Daniele M. Guizoni, Estela Lorza-Gil, Alessandro G. Salerno, Adriene A. Paiva, Gabriel G. Dorighello, Ana Paula Davel, Wayne Balkan, Joshua M. Hare, and Helena C. F. Oliveira

Subjects
CETP, oxidative stress, endoplasmic reticulum stress, endothelial dysfunction, superoxide, hydrogen peroxide, Microbiology, QR1-502
Abstract

Endothelial dysfunction precedes atherosclerosis and is an independent predictor of cardiovascular events. Cholesterol levels and oxidative stress are key contributors to endothelial damage, whereas high levels of plasma high-density lipoproteins (HDL) could prevent it. Cholesteryl ester transfer protein (CETP) is one of the most potent endogenous negative regulators of HDL-cholesterol. However, whether and to what degree CETP expression impacts endothelial function, and the molecular mechanisms underlying the vascular effects of CETP on endothelial cells, have not been addressed. Acetylcholine-induced endothelium-dependent relaxation of aortic rings was impaired in human CETP-expressing transgenic mice, compared to their non-transgenic littermates. However, endothelial nitric oxide synthase (eNOS) activation was enhanced. The generation of superoxide and hydrogen peroxide was increased in aortas from CETP transgenic mice, while silencing CETP in cultured human aortic endothelial cells effectively decreased oxidative stress promoted by all major sources of ROS: mitochondria and NOX2. The endoplasmic reticulum stress markers, known as GADD153, PERK, and ARF6, and unfolded protein response effectors, were also diminished. Silencing CETP reduced endothelial tumor necrosis factor (TNF) α levels, intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) expression, diminishing monocyte adhesion. These results support the notion that CETP expression negatively impacts endothelial cell function, revealing a new mechanism that might contribute to atherosclerosis.

Published
2021
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