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This paper focuses on the development and experimental testing of a potential clean energy source for powering the remote equipment used in transportation infrastructure. Traditional power sources (i.e., power cables and batteries) are excessively expensive or infeasible in this type of application. A compressionbased roadway energy harvester has been developed that can be embedded into pavement to scavenge electrical energy from traffic-induced vibrations. The proposed roadway harvester employs a group of piezoelectric harvesting units to convert traffic-induced vibrations into electrical energy, and each single harvesting unit contains three piezoelectric multilayer stacks. According to the linear theory of piezoelasticity, a two-degree-of-freedom electromechanical model of the piezoelectric harvesting unit was developed to characterize its performance in generating electrical energy under external excitations. Experimental testing in the laboratory was conducted to investigate the output power properties of the harvesting unit and shows good agreement with the theoretical analysis. Based on the testing results of the harvesting unit, the capability of the proposed roadway harvester has been theoretically evaluated and demonstrated that it has the ability to generate sufficient energy for driving common electrical equipment used in transportation infrastructure. [ABSTRACT FROM AUTHOR]

The coping strategy of a CANON (completely autotrophic nitrogen removal over nitrite) reactor working at room temperature was investigated using response surface methodology. The total nitrogen (TN) removal efficiency was taken as a dependent variable. The temperature (X), dissolved oxygen (DO) concentration (Y), and influent nitrogen loading rate (Z) were taken as independent variables. Results showed that the relation of these three independent variables can be described by the TN removal efficiency expressed as –5.03 + 1.51X + 45.16Y + 30.13Z+ 0.26XY + 1.84XZ– 0.04X2 – 9.06Y2 – 99.00Z2. The analysis of variance proved that the equation is applicable. The response surface demonstrated that the temperature significantly interacts with the DO concentration and influent N loading rate. A coping strategy for the CANON reactor working at room temperature is thus proposed: altering the DO concentration and the N loading rate to counterbalance the impact of low temperature. The verification test proved the strategy is viable. The TN removal efficiency was 91.3% when the reactor was operated under a temperature of 35.0 °C, a DO of 3.0 mg/L, and a N loading rate of 0.70 kgN/(m3d). When the temperature dropped from 35.0 to 19.2 °C, the TN removal efficiency was kept at 88.7% by regulating the influent N loading rate from 0.7 kgN/(m3d) to 0.35 kgN/(m3d) and the DO concentration from 3.0 to 2.6 mg/L. [ABSTRACT FROM AUTHOR]

Carbon fiber-reinforced polymer (CFRP) reinforcement technology has been widely used in the reinforcement of reinforced concrete (RC) beams. At this stage, high prestressed CFRP board reinforcement is often used in actual reinforcement. However, most reinforced bridges are designed for a long time, and the design value of the protective layer is low, and it is impossible to achieve a large prestressed tension. Therefore, this paper proposes the reverse-arch method to paste the CFRP board and apply low prestress to strengthen the symmetrical RC beam. Through the three-point forward loading test, the cracking load, ultimate load, crack width, mid-span deflection, strain and failure mode of a reverse-arch method-pasted CFRP board-reinforced beam, a directly pasted CFRP board-reinforced beam and an unreinforced beam are compared. The results show that the load-bearing capacity and stiffness of the test beam can be improved by pasting CFRP plates with anti-arch method, but the ductility of the test beam is reduced. Compared with the unreinforced beam, the maximum cracking load and ultimate load are increased by 56% and 63% respectively. The reverse-arch method can produce low prestress, improve the stiffness and bearing capacity of members, and has a good prospect of engineering application.

The slippage of cable clamps during the long-term operation of suspension bridges is a common and detrimental phenomenon. From an experimental point of view, the cable clamp slippage of a suspension bridge was investigated to reveal the effect of this sliding on the force acting on the full bridge. The forces acting on the bridge before and after the slippage were analyzed using a finite element model. The calculation results showed that the cable clamp slippage directly affects the cable forces of the hangers. The hanger cable force decreased by 19.2% when the slippage reached 10.2 cm, while the maximum increase in the cable force of adjacent hangers was 147.7 kN, an increase of 7.25%. The variation of forces in the hanger cable disrupted the force balance of the main girder, thereby producing a torque effect at the corresponding position in the girder, i.e., increased torque. Meanwhile, the slippage affected the axial tension in the main cable and the main girder. The impact of the tower internal force was less than 1%. Hence, the study concluded that the effect of cable clamp slippage is better understood, ensuring the safety of the suspension bridge.

The magnetorheological (MR) shock absorber is one of the most promising new devices for vibration reduction. Many investigations have been carried out on low velocity and frequency applications of MR devices. The use of the MR shock absorber under impact load is of great interest. The now widely used MR damper models, such as the Bingham model, cannot explain sufficiently the shear thinning behavior under impact loads. However, the Herschel-Bulkley model can be used to explain the same. The main purpose of this study is to analyze the behavior of the MR shock absorber under impact load and to verify the analytical conclusions and experiments. First, some dynamic simulations on the MR shock absorber under impact loads in Matlab and Simulink are carried out. The model describes the dynamic characteristics especially the shear thinning behavior of the shock absorber, based on this model, then analyzes the variations of piston acceleration and back cavity pressure of MR shock absorber at both same and different flow indices. A test rig is developed to test the characteristics of the long-stroke MR shock absorber under impact loads. Comparisons between the simulation and the test results are made to validate our conclusions. The results indicate that the peak acceleration value of the piston rod and the pressure of the back cavity are decided by the peak value and the duration of the impact force. The peak value of the acceleration and the cavity pressure cannot be changed, but the transitional time of the acceleration of the piston and the pressure of the back cavity of MR shock absorber can be controlled by changing the applied current in the electromagnetic coil. MR shock absorbers will be the most promising shock reduction device under an impact environment. [ABSTRACT FROM AUTHOR]

The article focuses on various issues taken up for discussion in various articles of the September 2005 issue of the journal "Chinese Education and Society," including one on the perception of the teachers of higher education regarding their careers and the other related to the fears of the teachers of higher education.

Based on study on the main factors affecting the initial productivity of directional wells in multilayer sandstone reservoirs of Penglai 19-3 oil field, a permeability interpretation model based on lithofacies constraint was established, and an initial productivity prediction formula for directional wells in offshore multilayer sandstone reservoirs was derived. Permeability and oil saturation are the main factors affecting initial productivity of directional wells in Penglai 19-3 oil field. Using core, scanning electron microscope, casting thin section, logging and production data, and a new permeability interpretation model considering the influence of macro sedimentary characteristics and microscopic pore structure was built. On the basis of permeability correction, resistivity increase ratio is introduced to characterize the effect of oil saturation, to modify the Vandervlis productivity formula of directional wells to get an initial productivity prediction equation suitable for continental multilayer sandstone reservoirs. The study results show that the permeability considering petrographic constraints and the production forecasting formula including resistivity increase ratio are more accurate. Key words: multilayer commingled production, permeability characterization, oil saturation, directional well, initial productivity prediction, Penglai 19-3 oil field, Bohai Bay Basin

Emerging literature indicates the essential roles of long noncoding RNA (lncRNA) in the osteosarcoma (OS). However, the regulatory function and mechanism of FOXD2-AS1 in the OS is still elusive. In present research, the level of FOXD2-AS1 was significantly up-regulated in the OS tissue and cell lines compared to corresponding controls. The aberrant high-expression of FOXD2-AS1 indicated the poor clinical prognosis of OS patients. Transcription factor HIF-1α could bind with the promoter region of FOXD2-AS1 to activate the transcription in OS cells. Functionally, the knockdown of FOXD2-AS1 could repress the malignant biological properties of OS cells in vitro and vivo, including proliferation, invasion, apoptosis and tumor growth. Mechanistically, FOXD2-AS1 inhibited the expression of p21 via interacting with EZH2 to silence p21 gene expression. Overall, we conclude that FOXD2-AS1, induced by transcription factor HIF-1α, acts as an oncogene in the OS tumorigenesis and FOXD2-AS1 interacts with EZH2 to silence p21 protein. This finding could provide a novel insight and potential therapeutic target for the OS.

A collective action that considerably affects government management and public security, e.g., a mass demonstration, usually experiences a long development period, originating from small and uncertain variations called weak signals on social media. Researchers generally identify collective action by small changes in communication frequency, emerging key words, and sentiment. However, most studies only consider the present environment, which may not evolve into a collective action, or conduct a short-term prediction in which significant damage is already done when the collective action is identified. This paper proposes a predictive framework to identify potential collective actions, considering the future evolution as well as the present situation, and providing a reference for early decision making. In the framework, a future sign to describe events is improved and the enhanced gray system theory is used to predict the evolution of a future sign. Mentions of events surrounding the Arab Spring-using over 300000 different open-content Web sources crawled from social media in seven different languages-are analyzed, which suggests that the predictive framework can more precisely identify the weak signals of collective actions.

Due to the existence of line impedances and low-bandwidth communication, the traditional peer-to-peer control method based on droop control has difficult meeting the requirements of current sharing and voltage stability in islanded DC microgrids at the same time. In this paper, a novel current-sharing control strategy based on injected small ac voltage with low frequency and low amplitude is proposed for multiple paralleled DC−DC converters. The small ac voltage is superimposed onto the output voltage of each converter. Then, the reactive circulating power is generated and used to regulate the output DC voltage of each converter. Under the droop characteristic between the injected frequency and output DC current, a feedback mechanism is generated to realize the accurate current sharing. On this basis, a reactive power-voltage limiter link and virtual negative impedance are added. Under the interaction of the two links, the bus voltage drop caused by line impedances can be almost completely eliminated. This method does not need any communication or to change the hardware structure. The controller design process is presented in detail along with a system stability analysis. Finally, the feasibility and effectiveness of the proposed control strategy are validated by the results obtained from simulations and experiments.

This paper investigates the impact of temperature on the rheological properties of magnetorheological (MR) grease containing carbonyl iron suspended in lithium-based grease Lithium-based MR grease with 70% weight fraction of carbonyl iron is firstly prepared by mechanical mixing. The apparent viscosity and shear stress as a function of shear rate under different temperatures and magnetic field strengths are measured and discussed. It is found that the influence of temperature on apparent viscosity reduces with the increase of magnetic field strength. The dynamic properties of MR grease are obtained under oscillatory shear test. The influences of strain amplitude, driving frequency and magnetic field on the dynamic properties of MR grease at different temperature are discussed. The results demonstrate that the enhancement of temperature leads to the increase of storage modulus and the reduction of the loss factor. Microstructural variation of grease matrix at different temperature is proposed as an explanation of the rheological changes of MR grease. [ABSTRACT FROM AUTHOR]

Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to support growth in macrophages. By conducting an extensive, unbiased chemical screen to identify small molecules that inhibit Mtb metabolism within macrophages, we identified a significant number of novel compounds that limit Mtb growth in macrophages and in medium containing cholesterol as the principle carbon source. Based on this observation, we developed a chemical-rescue strategy to identify compounds that target metabolic enzymes involved in cholesterol metabolism. This approach identified two compounds that inhibit the HsaAB enzyme complex, which is required for complete degradation of the cholesterol A/B rings. The strategy also identified an inhibitor of PrpC, the 2-methylcitrate synthase, which is required for assimilation of cholesterol-derived propionyl-CoA into the TCA cycle. These chemical probes represent new classes of inhibitors with novel modes of action, and target metabolic pathways required to support growth of Mtb in its host cell. The screen also revealed a structurally-diverse set of compounds that target additional stage(s) of cholesterol utilization. Mutants resistant to this class of compounds are defective in the bacterial adenylate cyclase Rv1625/Cya. These data implicate cyclic-AMP (cAMP) in regulating cholesterol utilization in Mtb, and are consistent with published reports indicating that propionate metabolism is regulated by cAMP levels. Intriguingly, reversal of the cholesterol-dependent growth inhibition caused by this subset of compounds could be achieved by supplementing the media with acetate, but not with glucose, indicating that Mtb is subject to a unique form of metabolic constraint induced by the presence of cholesterol.

The aim of this prospective randomized double-blind clinical study is to examine the benefits of using olfactory ensheathing cells (OECs) combined with or without Schwann cells (SCs) in treating chronic complete spinal cord injuries (SCIs). This would offer patients a better alternative for neurological functional recovery. According to the initial design, 28 eligible participants with cervical chronic complete SCI were recruited and randomly allocated into four groups of seven participants each. The neurological assessments were to be performed according to the American Spinal Injury Association (ASIA) and International Association of Neurorestoratology (IANR) Functional Rating Scales, in combination with electrophysiological tests, for example, electromyography (EMG) and paraspinal somatosensory evoked potentials (PSSEPs). Here we have summarized the data from seven patients; three patients received an OEC intraspinal transplantation, one underwent SC implantation, and one received a combination of OECs and SCs. The remaining two patients were used as controls. The scores were evaluated independently by at least two neurologists in a blinded fashion for comparing the neurological functional changes during pre- and post-cell transplantation (6-month follow-up). All patients who received OECs, SCs alone, and a combination of them showed functional improvement. Mild fever occurred in one of the patients with OEC transplant that subsided after symptomatic treatments. All treated patients except one showed improvement in the electrophysiological tests. The functional improvement rate comprises 5/5 (100%) in the treated group, but 0/2 (0%) in the control group ( p = 0.008). These preliminary findings show that transplanting OECs, SCs, or a combination of them is well tolerated and that they have beneficial effects in patients. Thus, further studies in larger patient cohorts are warranted to assess the benefits and risks of these intervention strategies. This manuscript is published as part of the IANR special issue of Cell Transplantation .

A safety and arming (S&A) device keeps the fuze of a projectile unarmed during shipping, handling and storage, while arming the firing section at a proper time by sensing external conditions such as pressure, position, etc. With the increasing need for smaller S&A devices, a miniature design with a compact configuration and high reliability is in demand. This paper proposes a miniaturized timing trigger as the S&A device for a spinning projectile by utilizing the ‘locking’ and ‘unlocking’ properties of magnetorheological (MR) grease with/without the presence of a magnetic field. First, the design and arming mechanism of the timing trigger are introduced, in which the MR grease is locked by a magnetic field generated by two permanent magnets (PMs). Under sufficient firing acceleration, the PMs disengage to unlock the contraction flow of the MR grease, which enables its triggering function. A theoretical analysis was conducted to interpolate the delay time against the geometry of the device, the shear/extensional characteristics of MR grease and the spinning rate of a projectile. A series of tests have been conducted to measure the delay times by tuning the physical parameters, including particle concentration, spinning rate and orifice diameter etc. The experimental results showed that this theoretical model is capable of calculating well the delay time of a MR grease timing trigger. [ABSTRACT FROM AUTHOR]

Time delay is a challenge issue faced by the real-time control application of the magnetorheological (MR) devices. Not to deal with it properly may jeopardize the effectiveness of the control, even lead to instability of the control system or catastrophic failure. This paper proposes a dual-loop adaptive control to address the response time delay associated with MR devices. In the proposed dual-loop control, the inner loop is designed to compensate the time delay of MR device induced by the PWM current driver. While the outer loop control can be any structural control algorithm with aims to reducing structural responses of a building during extreme loadings. Here an adaptive control strategy is adopted. To verify the proposed dual-loop control, a smart base isolation system employing magnetorheological elastomer base isolators is used as an example to illustrate the control effect. Numerical study is then conducted using a 5 -storey shear building model equipped with smart base isolation system. The result shows that with the implementation of the inner loop, the control current can instantly follow the control command which reduce the possibility of instability caused by the time delay. Comparative studies are conducted between three control strategies, i.e. dual-loop control, Lyapunov’s direct method based control and optimal passive base isolation control. The results of the study have demonstrated that the proposed dual-loop control strategy can achieve much better performance than the other two control strategies. [ABSTRACT FROM AUTHOR]

The aim of this study is to explore the safety and therapeutic effect of multiple cell transplantations on patients with multiple system atrophy. Ten patients suffering from multiple system atrophy were treated by multiple cell transplantations from August 2005 to March 2011. They were six males and four females, with an average age of 51.90 ± 12.92 years (23–66 years). Multiple cell types were transplanted by intravenous, intrathecal, and intracranial routes; for example, 0.4–0.5 × 10 6 /kg umbilical cord mesenchymal cells by intravenous drip, intrathecal implantation of 2.0 × 10 6 Schwann cells and 2.0–5.0 × 10 6 neural progenitor cells through cerebellar cistern puncture, or 2 × 10 6 olfactory ensheathing cells and 4 × 10 6 neural progenitor cells injected into key points for neural network restoration (KPNNR). The neurological function was assessed before and after treatment with the International Cooperative Ataxia Rating Scale (ICARS) by the World Federation of Neurology and the Unified Multiple System Atrophy Rating Scale (UMSARS). The patients achieved neurological function amelioration after treatment, which included improvements in walking ability, gaits, standing, speech, and muscular tension; the ICARS score decreased from a preoperative 46.30 ± 14.50 points to postoperative 41.90 ± 18.40 points ( p = 0.049). The UMSARS score decreased from preoperative 50.00 ± 20.65 points to postoperative 46.56 ± 23.05 points ( p = 0.037). Among them, two patients remained stable and underwent a second treatment 0.5–1 year after the first therapy. After treatment, five patients were followed up for more than 6 months. Balance and walking ability improved further in four patients, while one patient remained stable for over 6 months. In conclusion, a strategy of comprehensive cell-based neurorestorative therapy for patients with multiple system atrophy is safe and appears to be beneficial. This manuscript is published as part of the International Association of Neurorestoratology (IANR) supplement issue of Cell Transplantation .

Stroke is the third leading cause of death worldwide and a huge perpetrator in adult disability. This pilot clinical study investigates the possible benefits of transplanting multiple cells in chronic stroke. A total of 10 consecutive stroke patients were treated by combination cell transplantation on the basis of an intraparenchymal approach from November 2003 to April 2011. There were six males and four females. Their age ranged from 42 to 87 years, and the course of disease varied from 6 months to 20 years. Six patients suffered cerebral infarction, and four patients suffered a brain hemorrhage. The olfactory ensheathing cells, neural progenitor cells, umbilical cord mesenchymal cells, and Schwann cells were injected through selected routes including intracranial parenchymal implantation, intrathecal implantation, and intravenous administration, respectively. The clinical neurological function was assessed carefully and independently before treatment and during a long-term follow-up using the Clinic Neurologic Impairment Scale and the Barthel index. All patients were followed up successfully from 6 months to 2 years after cell transplantation. Every subject achieved neurological function amelioration including improved speech, muscle strength, muscular tension, balance, pain, and breathing; most patients had an increased Barthel index score and Clinic Neurologic Impairment Scale score. These preliminary results demonstrate the novel strategy of combined multiple cell therapy based on intraparenchymal delivery: it appears to be relatively clinically safe and at least initially beneficial for chronic stroke patients. This manuscript is published as part of the International Association of Neurorestoratology (IANR) supplement issue of Cell Transplantation .

Our previous series of studies have proven that olfactory ensheathing cell (OEC) transplantation appears to be able to slow the rate of clinical progression after OEC transplantation in the first 4 months and cell intracranial (key points for neural network restoration, KPNNR) and/or intraspinal (impaired segments) implants provide benefit for patients (including both the bulbar onset and limb onset subtypes) with amyotrophic lateral sclerosis (ALS). Here we report the results of cell therapy in patients with ALS on the basis of long-term observation following multiple transplants. From March of 2003 to January of 2010, 507 ALS patients received our cellular treatment. Among them, 42 patients underwent further OEC therapy by the route of KPNNR for two or more times (two times in 35 patients, three times in 5 patients, four times in 1 patient, and five times in 1 patient). The time intervals are 13.1 (6–60) months between the first therapy and the second one, 15.2 (8–24) months between the second therapy and the third one, 16 (6–26) months between the third therapy and the fourth one, and 9 months between the fourth therapy and the fifth time. All of the patients exhibited partial neurological functional recovery after each cell-based administration. Firstly, the scores of the ALS Functional Rating Scale (ALS-FRS) and ALS Norris Scale increased by 2.6 + 2.4 (0–8) and 4.9 + 5.2 (0–20) after the first treatment, 1.1 + 1.3 (0–5) and 2.3 + 2.9 (0–13) after the second treatment, 1.1 + 1.5 (0–4), and 3.4 + 6.9 (0–19) after the third treatment, 0.0 + 0.0 (0–0), and 2.5 + 3.5 (0–5) after the fourth treatment, and 1 point after the fifth cellular therapy, which were evaluated by independent neurologists. Secondly, the majority of patients have achieved improvement in electromyogram (EMG) assessments after the first, second, third, and fourth cell transplantation. After the first treatment, among the 42 patients, 36 (85.7%) patients' EMG test results improved, the remaining 6 (14.3%) patients' EMG results showed no remarkable change. After the second treatment, of the 42 patients, 30 (71.4%) patients' EMG results improved, 11 (26.2%) patients showed no remarkable change, and 1 (2.4%) patient became worse. After the third treatment, out of the 7 patients, 4 (57.1%) patients improved, while the remaining 3 (42.9%) patients showed no change. Thirdly, the patients have partially recovered their breathing ability as demonstrated by pulmonary functional tests. After the first treatment, 20 (47.6%) patients' pulmonary function ameliorated. After the second treatment, 18 (42.9%) patients' pulmonary function improved. After the third treatment, 2 (28.6%) patients recovered some pulmonary function. After the fourth and fifth treatment, patients' pulmonary function did not reveal significant change. The results show that multiple doses of cellular therapy definitely serve as a positive role in the treatment of ALS. This repeated and periodic cell-based therapy is strongly recommended for the patients, for better controlling this progressive deterioration disorder.

The neurorestorative effect of the parenchymal transplantation of olfactory ensheathing cells (OECs) for cord trauma remains clinically controversial. The aim of this article is to study the long-term result of OECs for patients with complete chronic spinal cord injury (SCI). One hundred and eight patients suffered from complete chronic SCI were followed up successfully within the period of 3.47 ± 1.12 years after OEC therapy. They were divided into two groups based on the quality and quantity of their rehabilitative training: group A ( n = 79) in sufficient rehabilitation (or active movement-target enhancement-neurorehabilitation therapy, AMTENT) and group B ( n = 29) in insufficient rehabilitation. All patients were assessed by using the American Spinal Injury Association (ASIA) standard and the International Association of Neurorestoratology Spinal Cord Injury Functional Rating Scale (IANR-SCIFRS). Thirty-one patients were evaluated by the tests of magnetic resonance imaging (MRI), electromyography (EMG), and paravertebral sensory evoked potential (PVSEP). We found the following. 1) According to ASIA and IANR-SCIFRS assessment for all 108 patients, averaged motor scores increased from 37.79 ± 18.45 to 41.25 ± 18.18 ( p 0.05). 3) Comparing group A with group B, the increased scores in terms of motor, light touch, and pin prick were remarkably different (all p < 0.01), but not IANR-SCIFRS ( p > 0.05). 4) Fourteen of 108 patients (12.96%) became ASIA B from ASIA A; 18 of 108 (16.67%) became ASIA C from ASIA A. Nine of them (8.33%) improved their walk ability or made them rewalk by using a walker with or without assistance; 12 of 84 men (14.29%) improved their sex function. 5) MRI examinations were taken for 31 patients; there were no neoplasm, bleeding, swelling, cysts, neural tissue destruction or infection (abscess) or any other pathological changes in or around OEC transplant sites. 6) EMG examinations were done on 31 patients; 29 showed improvement and the remaining 2 had no change. PVSEP tests were performed in 31 patients; 28 showed improvements and the remaining 3 had no change. 7) No deterioration or complications were observed in our patients within the follow-up period. Our data suggest OEC therapy is safe and can improve neurological functions for patients with complete chronic SCI and ameliorate their quality of life; the AMTENT most likely plays a critical role in enhancing functional recovery after cell-based neurorestorotherapy.

Plumbagin and its Cu (II) complex [Cu (plumbagin)2]·H2O have been synthesized, and their antioxidant activities towards the inhibitory effect on DPPH free radical, reducing power, total antioxidant capacity, and inhibition on lipid peroxidation were investigated. Plumbagin and its Cu (II) complex were found to exhibit scavenging activities on DPPH radical with the inhibitory rate of 41% and 24%, respectively. The reducing power of plumbagin was outstanding at the concentrations of 1.0, 1.5, and 2.0 mg/mL, compared to Cu (II) complex and synthetic antioxidant 2,6-di-ter-butyl-4-methylphenol (BHT); the highest level reached 1.333 for plumbagin and 0.581 for Cu (II) complex. Also, the inhibition on lipid peroxidation of plumbagin was higher than that of Cu (II) complex and BHT, 46.4% for plumbagin and 24.5% for Cu (II) complex. The results give a strong impact for designing anticancer drugs, combined with their potential cytotoxic and antioxidant activities, which can be targeted selectively against cancer cells and increase their therapeutic index and additional advantages over other anticancer drugs.

Successful repair of damage in cerebral palsy (CP) needs effective clinical interventions other than simply symptomatic treatments. To elucidate the feasibility of using olfactory ensheathing cells (OECs) to treat CP in children and adolescents, we conducted a randomized controlled clinical trial (RCT) on 33 patients. The patients were randomly assigned into two groups (treatment group, n = 18; control group, n = 15), and OECs derived from aborted fetal tissue were injected into the bilateral corona radiata in the frontal lobes (a key point for neural network restoration, KPNNR). The Gross Motor Function Measure (GMFM-66) and the Caregiver Questionnaire Scale were used to evaluate the patients' neurological function and overall health status. Among the 14 patients who completed the 6-month study, six received the cell transplantation and the other eight served as controls. In OEC treatment group, GMFM-66 scores were 26.67 ± 25.33 compared with 19.00 ± 20.00 for the control group. Concurrently, the Caregiver Questionnaire Scale score decreased to 77.83 ± 15.99 in the treatment group in comparison to 138.66 ± 64.06 of the control group. This trial, albeit small in sample size, indicates OEC KPNNR transplantation is effective for functional improvement in children and adolescents with CP, yet without obvious side effects. This small-scale study suggests that the procedure may be a plausible alternative method to treat this not yet curable disorder, and we urge further evaluation with a large-scale RCT.

This paper reports an investigation on a semi-active/passive integrated vibration isolator utilizing a magnetorheological elastomer (MRE) and spring. To overcome the main shortcoming of passive isolation systems, i.e. lack of adaptability, the semi-active/passive integrated isolator (SAPII) based on an MRE and spring is designed and prototyped. The magnetic circuit is optimized by finite element analysis to fully unlock the unique features of the MRE. The dynamic response characteristic of the SAPII is experimentally investigated under a sweep frequency test. A dynamic model of the SAPII vibration isolation system is established on the basis of the Kelvin model. The model parameters, such as equivalent stiffness and equivalent damping, are identified from experimental data. An ON-OFF control law based on the minimal displacement transmissibility is designed for isolation control of the sinusoid excitation. Two control laws, i.e. ON-OFF control and fuzzy logic control, are designed for vibration isolation of random excitation. Finally, the effectiveness of these control laws is verified by numerical simulation and experiment. [ABSTRACT FROM AUTHOR]

Utilising the unique features of MRE materials for vibration isolators has been intensively studied over the last several years. Real-time control of the MRE isolators holds the key to unlock MRE materials’ unique characteristics, i.e. instantly changeable shear modulus in continuous and reverse fashion. However, one of the critical issues for the applications of real-time control is the response time delay of MRE vibration isolators, which has not yet been fully addressed and studied. This paper identified the inherent response time of the MRE isolator and explored two feasible approaches to minimise the response time delay. Experiments were designed and conducted to evaluate the effectiveness of the proposed approaches on minimising time delay on: (i) the transient response of current of a large coil that generates magnetic field and (ii) the transient response of shear force from the MRE isolator. The results show that the proposed approaches are effective and promising. For example, the proposed approach is able to reduce the force response time from 421 ms to 52 ms at rising and from 400 ms to 48 ms falling edges respectively. Such level of short response time of the MRE isolators demonstrates the feasibility of application of real-time control and hence is the essential step on the realisation of real-time control of vibration suppression system based on MRE isolator. [ABSTRACT FROM AUTHOR]

This paper proposes a new type of magnetorheological elastomer (MRE) using rubber from waste tires and describes its performance characteristics. In this work, scrap tires were utilized as a primary matrix for the MRE without incorporation of virgin elastomers. The synthesis of the scrap tire based MRE adopted a high-temperature high-pressure sintering technique to achieve the reclaiming of vulcanized rubber. The material properties of the MRE samples were investigated through physical and viscoelastic examinations. The physical tests confirmed several material characteristics—microstructure, magnetic, and thermal properties–while the viscoelastic examination was conducted with a laboratory-made dynamic compression apparatus. It was observed from the viscoelastic examination that the proposed MRE has magnetic-field-dependent properties of the storage modulus, loss modulus, and loss tangent at different excitation frequencies and strain amplitudes. Specifically, the synthesized MRE showed a high zero field modulus, a reasonable MR effect under maximum applied current, and remarkable damping properties. [ABSTRACT FROM AUTHOR]

This paper presents multi-physics modeling of an MR absorber considering the magnetic hysteresis to capture the nonlinear relationship between the applied current and the generated force under impact loading. The magnetic field, temperature field, and fluid dynamics are represented by the Maxwell equations, conjugate heat transfer equations, and Navier–Stokes equations. These fields are coupled through the apparent viscosity and the magnetic force, both of which in turn depend on the magnetic flux density and the temperature. Based on a parametric study, an inverse Jiles–Atherton hysteresis model is used and implemented for the magnetic field simulation. The temperature rise of the MR fluid in the annular gap caused by core loss (i.e. eddy current loss and hysteresis loss) and fluid motion is computed to investigate the current–force behavior. A group of impulsive tests was performed for the manufactured MR absorber with step exciting currents. The numerical and experimental results showed good agreement, which validates the effectiveness of the proposed multi-physics FEA model. [ABSTRACT FROM AUTHOR]

Due to its inherent hysteretic characteristics, the main challenge for the application of a magnetorheological elastomer- (MRE) based isolator is the exploitation of the accurate model, which could fully describe its unique behaviour. This paper proposes a nonparametric model for a MRE-based isolator based on support vector regression (SVR). The trained identification model is to forecast the shear force of the MRE-based isolator online; thus, the dynamic response from the MRE-based isolator can be well captured. In order to improve the forecast capacity of the model, a type of improved particle swarm optimization (IPSO) is employed to optimize the parameters in SVR. Eventually, the trained model is applied to the MRE-based isolator modelling with testing data. The results indicate that the proposed hybrid model has a better generalization capacity and better recognition accuracy than other conventional models, and it is an effective and suitable approach for forecasting the behaviours of a MRE-based isolator. [ABSTRACT FROM AUTHOR]

During the last few decades, magnetorheological (MR) elastomers have attracted a significant amount of attention for their enormous potential in engineering applications. Because they are a solid counterpart to MR fluids, MR elastomers exhibit a unique field-dependent material property when exposed to a magnetic field, and they overcome major issues faced in magnetorheological fluids, e.g. the deposition of iron particles, sealing problems and environmental contamination. Such advantages offer great potential for designing intelligent devices to be used in various engineering fields, especially in fields that involve vibration reduction and isolation. This paper presents a state of the art review on the recent progress of MR elastomer technology, with special emphasis on the research and development of MR elastomer devices and their applications. To keep the integrity of the knowledge, this review includes a brief introduction of MR elastomer materials and follows with a discussion of critical issues involved in designing magnetorheological elastomer devices, i.e. operation modes, coil placements and principle fundamentals. A comprehensive review has been presented on the research and development of MR elastomer devices, including vibration absorbers, vibration isolators, base isolators, sensing devices, and so on. A summary of the research on the modeling mechanical behavior for both the material and the devices is presented. Finally, the challenges and the potential facing magnetorheological elastomer technology are discussed, and suggestions have been made based on the authors’ knowledge and experience. [ABSTRACT FROM AUTHOR]

A correction to the article "A highly adjustable magnetorheological elastomer base isolator for applications of real-time adaptive control" that was published in a 2013 issue of the periodical is presented.