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Obtaining high precision temperature data is crucial in spaceflight applications, considering the growing demand for high precision temperature measurement and the limited onboard resources with a harsh thermal environment in the spacecraft. How to obtain the data, however, becomes an urgent problem. Kalman filtering method is one of the solutions to obtain high precision temperature data with such limited resources. In this paper, the authors demonstrate the principle of temperature measurement system, the application of Kalman filter in temperature measurement including the processing method of sensor self-heating effect, and establishes the state space of measurement error and system error. Through the test, it could be seen that Kalman filtering can improve the temperature measurement resolution to the order of 100 μK while effectively reducing the temperature measurement bias.

Dual-state emission (DSE) luminogens, a type of luminescent material which can effectively emit light in both dilute solution and solid states, have attracted tremendous attention, due to their widespread applications in chemical sensing, biological imaging, organic electronic devices, and so on. They overcome the shortcomings of aggregation-induced emission (AIE)-type compounds that do not emit light in dilute solutions and aggregation-caused quenching (ACQ)-type compounds that do not emit light in a concentrated or aggregated state. This work reports a novel ionic DSE material based on rigid rod-shaped organic conjugated structure using 4,4′-bis(2-sulfonatostyryl) biphenyl disodium salt (BSBDS); the ion repulsion effect can reduce the strong π–π interaction in aggregation and achieve high-efficiency luminescence in solution and solid states. In addition to excellent DSE characteristics, BSBDS also exhibits a mechanochromic nature and sensitive detection performance for aluminum ion (Al3+).

Complete trajectory planning includes path planning, inverse solution solving and trajectory optimization. In this paper, a highly smooth and time-saving approach to trajectory planning is obtained by improving the kinematic and optimization algorithms for the time-optimal trajectory planning problem. By partitioning the joint space, the paper obtains an inverse solution calculation based on the partitioning of the joint space, saving 40% of the inverse kinematics solution time. This means that a large number of computational resources can be saved in trajectory planning. In addition, an improved sparrow search algorithm (SSA) is proposed to complete the solution of the time-optimal trajectory. A Tent chaotic mapping was used to optimize the way of generating initial populations. The algorithm was further improved by combining it with an adaptive step factor. The experiments demonstrated the performance of the improved SSA. The robot’s trajectory is further optimized in time by an improved sparrow search algorithm. Experimental results show that the method can improve convergence speed and global search capability and ensure smooth trajectories.

Injectable hydrogels offer a new therapy option for irregular bone deformities. Based on gelatin methacryloyl (GelMA), bone marrow mesenchymal stem cells (BMSCs), and bone morphogenetic protein 2 (BMP2), we created a photo-crosslinked composite bioactive scaffold. The composite scaffolds had appropriate mechanical properties for stem cells adhesion and proliferation, as well as good biocompatibility and the ability to stimulate BMSCs osteogenic differentiation in vitro. The synergistic effect of BMSCs and BMP2 enabled the composite bioactive scaffold to exhibit higher osteogenic potential in vivo than scaffolds loaded alone with BMSCs or BMP2, according to imaging and histology studies. In conclusion, by promoting the osteogenic differentiation of BMSCs, the composite bioactive scaffold based on BMSCs-BMP2-GelMA has demonstrated remarkable application potential in bone regeneration and bone defects repair.

Organic room temperature phosphorescence (RTP) materials have received considerable attention due to their fascinating photophysical properties. During the past decade, various organic luminogens exhibiting RTP emission in solid states were reported. However, the phosphorescence emission of organic compounds can hardly be observed in their solutions at room temperature. Herein, we reported two fluorene derivatives that can emit RTP in degassed organic solvents, polymer doped film, and crystalline states. Furthermore, those RTP luminogens emitted different colors with different phosphorescence lifetimes in multi-states. These results indicated that the phosphorescence performance can be adjusted flexibly in different condensed states. To our knowledge, this is the first example possessing diverse organic RTP at multi-states, including solution state.

Rice stripe mosaic virus (RSMV), a newly discovered plant cytorhabdovirus, and rice gall dwarf virus (RGDV), a plant reovirus, are transmitted by leafhopper Recilia dorsalis in a persistent-propagative manner. In this study, field surveys in Luoding city, Guangdong province of southern China, showed that RSMV and RGDV frequently co-infected rice plants. Furthermore, this co-infection had a synergistic effect on viral replication potential and pathogenicity in rice plants. Meanwhile, RSMV and RGDV also co-infected R. dorsalis vectors, and RGDV significantly promoted the propagation of RSMV in co-infected vectors. Accordingly, co-infection significantly promoted the acquisition and transmission efficiencies of RSMV by R. dorsalis. However, such co-infection did not significantly affect the propagation of RGDV in vectors. More importantly, we also observed that non-viruliferous R. dorsalis preferred to feed on co-infected rice plants, and this process further affected the feeding behavior of R. dorsalis to enhance viral release into rice phloem. These results provided the clues as to why RSMV had been a gradually expanding problem, creating an increasing risk of damage to rice production. Our findings revealed that synergism between RSMV and RGDV in their host and vector enhanced the propagation and transmission of RSMV, which will help guide the formulation of viral control strategies.

SWI/SNF remodelers alter histone-DNA interactions and are important for regulating chromatin architecture and gene expression. Here, the authors present the cryo-EM structure of a nucleosome-free Swi/Snf complex from Saccharomyces cerevisiae and discuss the assembly and function of SWI/SNF remodelers.

With the widespread use of cadmium telluride solar cells, environmental protection, and effective recycling approaches for solar cell component waste have become topics of concern. As an emerging metal smelting technology, vacuum metallurgy technology has broad application prospects in primary metal refining and the recycling of secondary non-ferrous scraps. Thus, this study proposes a new method for the separation and recovery of rare metals from cadmium telluride waste through sulfur smelting and vacuum distillation. In this process, sulfur is smelted with cadmium telluride to produce tellurium with a high vapor pressure. The tellurium was then separated and purified by multi-stage vacuum distillation. The results show that the tellurium purity can reach up to 99.97% and the tellurium recovery rate was above 99%. The cadmium and sulfur contents in the tellurium were 0.0061% and 0.0194%, respectively. Moreover, the cadmium sulfide produced during the smelting process can be enriched by vacuum distillation, resulting in 99.6% purity. This technology strongly aligns with the “reduce, reuse, and recycle” principle for solid waste, and provides a basis for the sustainable development of the photovoltaic industry.

Two kinds of [3 + 2] cycloaddition intermediates generated from the three-component reactions of 2-bromobenzaldehydes and maleimides with amino esters or amino acids were used for a one-pot N-allylation and intramolecular Heck reactions to form pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines. The multicomponent reaction was combined with one-pot reactions to make a synthetic method with good pot, atom and step economy. MeCN was used as a preferable green solvent for the reactions.

Three low-cost adsorbents (purified raw attapulgite (A-ATP), high-temperature-calcined attapulgite (T-ATP), and hydrothermal loading of MgO (MgO-ATP)) were prepared as adsorbents for the removal of Cd(II) and Pb(II). By evaluating the effect of the initial solution pH, contact time, initial solution concentration, temperature and coexistence of metal ions on Cd(II) and Pb(II) adsorption, the experimental results showed that MgO-ATP was successfully prepared by hydrothermal reaction and calcination as well as appearing to be a promising excellent adsorbent. At an initial pH of 5.0, A-ATP, T-ATP and MgO-ATP reached maximum adsorption amounts of 43.5, 53.9 and 127.6 mg/g for Pb(II) and 10.9, 11.2, and 25.3 mg/g for Cd(II) at 298 K, respectively. The Cd(II) adsorption on A-ATP was fitted by the Freundlich model, while the adsorption of Pb(II) and Cd(II) on T-ATP and MgO-ATP as well as Pb(II) adsorption on A-ATP agreed with the Langmuir model. All kinetic experimental data favored pseudo second-order model. The calculated thermodynamic parameters suggested that Pb(II) adsorption onto MgO-ATP was spontaneous and exothermic. When considering foreign metal ions, the three adsorbents all presented preferential adsorption for Pb (II). Chemical adsorption had a high contribution to the removal of Cd(II) and Pb(II) by modified attapulgite. In summary, the adsorption was greatly enhanced by the hydrothermal loading of MgO. It aimed to provide insights into the MgO-ATP, which could be able to efficiently remove Cd(II) and Pb(II) and serve as an economic and promising adsorbent for heavy metal-contaminated environmental remediation. Keywords: Attapulgite clay, Cd, Pb, Adsorption, Modification, Aqueous solution

Plasma spray-physical vapor deposition (i.e., PS-PVD) is a promising method for obtaining advanced environmental barrier coatings (EBCs). The EBCs must meet some requirements in the application, in which the thermal cycle performance affects the service lifetime. The preparation of artificial vertical cracks in Yb2SiO5 coatings is an effective approach for meeting the requirements above because vertical cracks provide a strain tolerance. To clarify the formation mechanism of vertical cracks during the PS-PVD, the effects of coating thickness and substrate temperature on the formation of vertical cracks were investigated. In addition, the interactions of spray powder and plasma flame during coating deposition were also characterized by optical spectroscopy. It is indicated that vertical cracks are formed due to a thermal expansion mismatch between Yb2SiO5 and mullite coating, transient cooling after deposition and the nucleation of evaporated Yb2SiO5 as well. Keywords: Environmental barrier coatings, Yb2SiO5 coating, Vertical crack, PS-PVD

Five Camellia oleifera Abel seedling substrates were prepared using the conventional formula, but with the peat substituted by the composts of Camellia oleifera shell, pine chips, palm fiber residues, chicken manure, and sheep manure. The physical and chemical properties of the prepared substrates before and after seedling cultivation were determined and their effects on the growth of Camellia oleifera seedling were analyzed. It was found that the survival rates of the one-year-old seedlings produced from stem cuttings on all substrates at 6 months were greater than 97.5%. As compared with the conventional substrate, the substrates formulated with the composts were able to promote the seedling growth based upon height, ground diameter, root length and root volume measurement. The substrate prepared with the compost of Camellia oleifera shell+ palm fiber residue+ chicken manure (A3), vermiculite and perlite (6:3:1) was the most optimal, which gave 100% seedling survival rate, the greatest seedling height, and the largest ground diameter. In particular, the ground diameters and 26.67% of the seedling heights reached the grade 1 standard for two-year-old seedlings.

Background: Serpin peptidase inhibitor clade H, member 1 (SERPINH1) is a gene encoding a member of the serpin superfamily of serine proteinase inhibitors. The upregulated of SERPINH1 was associated with poor prognosis in breast cancer, stomach adenocarcinoma, and esophageal carcinoma. However, the role of SERPINH1 in pan-cancer is largely unexplored.Methods: SERPINH1 expression and the correlation with prognosis in human pan-cancer were analyzed by the Cancer Genome Atlas and the Genotype-Tissue Expression dataset. Pearson correlation analysis was applied to evaluate the role of SERPINH1 expression in tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), DNA methyltransferase, and common immunoregulators. Spearman’s correlation test was used to analysis SERPINH1 expression in tumor immune infiltration and infiltrating immune cells via the Tumor Immune Evaluation Resource database. Furtherly, immunohistochemistry staining of SERPINH1 was acquired from the Human Protein Atlas database for validation.Results: SERPINH1 was abnormally expressed in fourteen cancers. The high expression of SERPINH1 significantly reduced the overall survival (OS), disease-specific survival, and progression free interval in eleven cancers. Moreover, SERPINH1 expression was correlated with MMR, MSI, TMB, and DNA methylation in multiple types of cancer. Also, SERPINH1 expression showed strong association with immunoregulators and immune checkpoint markers in testicular germ cell tumors, brain lower grade glioma (LGG), pheochromocytoma and paraganglioma. In addition, SERPINH1 expression was related to immune cell infiltration in multiple cancers, particularly in breast invasive carcinoma, LGG, and liver hepatocellular carcinoma. The result of immunohistochemistry verification shown that SERPINH1 staining was higher in tumor samples than in normal tissue in colon adenocarcinoma, head and neck squamous cell carcinoma, kidney renal papillary cell carcinoma and cervical squamous cell carcinoma, which was consistent with the result of OS.Conclusion: Overall, these results indicate that SERPINH1 may serve as an important prognostic biomarker and correlate with tumor immunity in human pan-cancer.

Afamin is a member of the hepatokine that are strongly associated with various metabolic diseases. The relationship between afamin and nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aimed to explore the correlation between serum afamin levels and NAFLD. We analyzed 88 NAFLD patients and 88 age- and sex-matched healthy controls who took their health examinations at the First Affiliated Hospital, Zhejiang University School of Medicine. The association was further confirmed in 22 biopsy-confirmed NAFLD patients and 36 healthy controls. Serum afamin levels were evaluated using an enzyme-linked immunosorbent assay (ELISA). NAFLD patients had significantly higher serum afamin levels than the healthy controls (14.79 ± 5.04 mg/L versus 10.83 ± 3.24 mg/L; P

In this article, we investigate a boundary value problem for a coupled differential system of fractional order that the nonlinear term depends on the unknown functions as well as their lower order fractional derivatives. Firstly, we give Green’s functions and prove their properties; secondly, the existence and uniqueness of positive solutions are obtained by using some fixed point theorems. In addition, two examples are presented to demonstrate the application of our main results.

Echelon usage is an important usage and control method for double-life equipment considering calendar life, which can improve the utilization rate of equipment life and give full play to the economic benefits of the equipment. However, the life indicator considered by the most common echelon usage method is single, and most methods evaluate the echelon usage through the echelon uniformity of working life. The conclusions obtained are limited for the usage and control of double-life equipment, so it is necessary to study the life evaluation method considering calendar life. In this paper, by analyzing the life consumption law of double-life equipment, the recursive method is used to calculate the controllable life range in the process of echelon usage. The evaluation method of working life distribution considering calendar life is proposed. The equipment life reserve is evaluated according to the unit task quantity of the equipment. The results show that the new method can quickly analyze the equipment beyond the usage and control range, evaluate the distribution of working life more accurately, reflect the shortage of equipment reserve life, and has guiding significance for the usage and control of equipment.

When maximum speed of 160 km/h is reached and the axle load reaches 25–30 tons, the train wheels need to have high strength and toughness. The main chemical elements affecting the strength and toughness of the wheel were determined by the mechanical features of the samples with different chemical compositions. Through analysis of the impact fracture of typical specimens, the difference of wheel toughness was mainly reflected in the dimple band, crack source, and cleavage pattern. By SEM analysis of fracture cracks, the critical size difference was found to exist between the grains during brittle fracture, where the intergranular fracture between grains of different sizes is mainly due to the different interfacial stresses between grains of different sizes.

With the development of space exploration, high-power and high-voltage power systems are essential for future spacecraft applications. Because of the effects of space radiation such as single event burnout (SEB), the rated voltage of power devices in converters for a spacecraft power system is limited to a level much lower than that for traditional ground applications. Thus, multi-level DC/DC converters are good choices for high-voltage applications in spacecraft. In this paper, a fault-tolerant strategy is proposed for a three-level flying capacitor DC/DC converter to increase the reliability with minimal cost. There is no extra hardware needed for the proposed strategy; the fault tolerance of the converter is only achieved by changing the software control strategy. A stage analysis of the proposed strategy is provided in detail for different fault locations and ratios between the input and output voltage. Finally, a simulation model and prototype are built to verify the effectiveness of the proposed strategy.

Iron supplementation is necessary for the treatment of anemia, one of the most frequent complications in inflammatory bowel disease (IBD). However, oral iron supplementation leads to an exacerbation of intestinal inflammation. Gut barrier plays a key role in the pathogenesis of IBD. The aim of this study was to characterize the interrelationship between systemic iron, intestinal barrier and the development of intestinal inflammation in a dextran sulfate sodium (DSS) induced experimental colitis mice model. We found that DSS-treated mice developed severe inflammation of colon, but became much healthy when intraperitoneal injection with iron. Iron supplementation alleviated colonic and systemic inflammation by lower histological scores, restorative morphology of colonic villi, and reduced expression of pro-inflammatory cytokines. Moreover, intraperitoneal supplementation of iron enhanced intestinal barrier function by upregulating the colonic expressions of tight junction proteins, restoring intestinal immune homeostasis by regulating immune cell infiltration and T lymphocyte subsets, and increasing mucous secretion of goblet cells in the colon. High-throughput sequencing of fecal 16 S rRNA showed that iron injection significantly increased the relative abundance of Bacteroidetes, which was suppressed in the gut microbiota of DSS-induced colitis mice. These results provided evidences supporting the protective effects of systemic iron repletion by intraperitoneal injection of iron on intestinal barrier functions. The finding highlights a novel approach for the treatment of IBD with iron injection therapy.

Diabetic kidney disease (DKD) is the most common cause of end-stage kidney disease worldwide and is the main microvascular complication of diabetes. The increasing prevalence of diabetes has increased the need for effective treatment of DKD and identification of new therapeutic targets for better clinical management. Mitophagy is a highly conserved process that selectively removes damaged or unnecessary mitochondria via the autophagic machinery. Given the important role of mitophagy in the increased risk of DKD, especially with the recent surge in COVID-19-associated diabetic complications, in this review, we provide compelling evidence for maintaining homeostasis in the glomeruli and tubules and its underlying mechanisms, and offer new insights into potential therapeutic approaches for treatment of DKD.

Radiant floor cooling (RFC) systems are known for their energy efficiency and comfort. However, when a conventional intermittently operating RFC system is subjected to sudden increases in heat and moisture loads, condensation, difficulties with multi-zone temperature control, inadequate cooling capacity, thermal comfort degradation, and slow thermal response may occur. A non-centralized hybrid RFC system was established with an air source heat pump, floor coils of high thermal mass, fan coils, and an outdoor air dehumidifier. The thermal comfort and cooling capacity of a given thermal zone under four modes were tested and analyzed. The results showed that the system created a satisfactory indoor environment with multi-zone control. The precooling direct-expansion (DX) outdoor air dehumidifier combined with the fan coils served the role of a conventional dispersed DOAS (dedicated outdoor air system), improved the response of the radiant system, and assisted in dehumidification. A PID-based mixing valve allows the floor surface temperature to track the dew point temperature of the zone air to improve floor cooling capacity. This hybrid system is suitable for residential homes or offices with non-centralized air conditioning systems to handle transient heat and moisture load variations.

Background: Stomach adenocarcinoma (STAD) is a significant global health problem. It is urgent to identify reliable predictors and establish a potential prognostic model.Methods: RNA-sequencing expression data of patients with STAD were downloaded from the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) database. Gene expression profiling and survival analysis were performed to investigate differentially expressed genes (DEGs) with significant clinical prognosis value. Overall survival (OS) analysis and univariable and multivariable Cox regression analyses were performed to establish the prognostic model. Protein–protein interaction (PPI) network, functional enrichment analysis, and differential expression investigation were also performed to further explore the potential mechanism of the prognostic genes in STAD. Finally, nomogram establishment was undertaken by performing multivariate Cox regression analysis, and calibration plots were generated to validate the nomogram.Results: A total of 229 overlapping DEGs were identified. Following Kaplan–Meier survival analysis and univariate and multivariate Cox regression analysis, 11 genes significantly associated with prognosis were screened and five of these genes, including COL10A1, MFAP2, CTHRC1, P4HA3, and FAP, were used to establish the risk model. The results showed that patients with high-risk scores have a poor prognosis, compared with those with low-risk scores (p = 0.0025 for the training dataset and p = 0.045 for the validation dataset). Subsequently, a nomogram (including TNM stage, age, gender, histologic grade, and risk score) was created. In addition, differential expression and immunohistochemistry stain of the five core genes in STAD and normal tissues were verified.Conclusion: We develop a prognostic-related model based on five core genes, which may serve as an independent risk factor for survival prediction in patients with STAD.

Feed conversion efficiency (FCE) is an economically crucial trait in fish, however, little progress has been made in genetics and genomics for this trait because phenotypes of the trait are difficult to measure. In this study, we constructed a high-density and high-resolution genetic linkage map with 28,416 SNP markers for common carp (Cyprinus carpio) based on high throughput genotyping with the carp 250K single nucleotide polymorphism (SNP) array in a full-sib F1 family of mirror carp (Cyprinus carpio) consisting of 141 progenies. The linkage map contained 11,983 distinct loci and spanned 3,590.09 cM with an average locus interval of 0.33 cM. A total of 17 QTL for the FCE trait were detected on four LGs (LG9, LG20, LG28, and LG32), explaining 8.9–15.9% of the phenotypic variations. One major cluster containing eight QTL (qFCE1-28, qFCE2-28, qFCE3-28, qFCE4-28, qFCE5-28, qFCE6-28, qFCE7-28, and qFCE8-28) was detected on LG28. Two clusters consisting of four QTL (qFCE1-32, qFCE2-32, qFCE3-32, and qFCE4-32) and three QTL (qFCE1-20, qFCE2-20, and qFCE3-20) were detected on LG32 and LG20, respectively. Nine candidate genes (ACACA, SCAF4, SLC2A5, TNMD, PCDH1, FOXO, AGO1, FFAR3, and ARID1A) underlying the feed efficiency trait were also identified, the biological functions of which may be involved in lipid metabolism, carbohydrate metabolism, energy deposition, fat accumulation, digestion, growth regulation, and cell proliferation and differentiation according to GO (Gene Ontology). As an important tool, high-density and high-resolution genetic linkage maps play a crucial role in the QTL fine mapping of economically important traits. Our novel findings provided new insights that elucidate the genetic basis and molecular mechanism of feed efficiency and the subsequent marker-assisted selection breeding in common carp.

There is increasing evidence that the natural environment provides substantial benefits to human emotional well-being. The current study synthesized this body of research using the meta-analysis and assessed the positive and negative effects of exposure to both the natural and built environments. We searched four databases and 20 studies were included in the review. The meta-analysis results showed the most convincing evidence that exposure to the natural environment could increase positive affect (standardized mean difference, SMD = 0.61, 95% CI 0.41, 0.81) and decreased negative affect (SMD = −0.47, 95% CI −0.71, −0.24). However, there was extreme heterogeneity between the studies, and the risk of bias was high. According to the subgroup analysis, study region, study design, mean age of the sample, sample size, and type of natural and built environment were found to be important factors during exposure to the natural environment. The implications of these findings for the existing theory and research are discussed. These findings will help convince the health professionals and policymakers to encourage the residents to increase their time spent in the natural environment. These findings of this systematic review also suggested that the creation, maintenance, and enhancement of accessible greenspaces or existing natural environments may form part of a multidimensional approach to increasing emotional well-being of the local populations.

Because of the unique physical and chemical properties of water, obtaining high-quality underwater images directly is not an easy thing. Hence, recovery and enhancement are indispensable steps in underwater image processing and have therefore become research hotspots. Nevertheless, existing image-processing methods generally have high complexity and are difficult to deploy on underwater platforms with limited computing resources. To tackle this issue, this paper proposes a simple and effective baseline named UIR-Net that can recover and enhance underwater images simultaneously. This network uses a channel residual prior to extract the channel of the image to be recovered as a prior, combined with a gradient strategy to reduce parameters and training time to make the operation more lightweight. This method can improve the color performance while maintaining the style and spatial texture of the contents. Through experiments on three datasets (MSRB, MSIRB and UIEBD-Snow), we confirm that UIR-Net can recover clear underwater images from original images with large particle impurities and ocean light spots. Compared to other state-of-the-art methods, UIR-Net can recover underwater images at a similar or higher quality with a significantly lower number of parameters, which is valuable in real-world applications.

Recently, deep learning has been widely used in the segmentation tasks of remote sensing images. However, the existing deep learning method most focus on local contextual information and has limited field of perception, which makes it difficult to capture the long-range contextual feature of objects at large scales form very-high-resolution (VHR) images. In this paper, we present a novel Local–global Framework consisting of the dual-source fusion network and local–global transformer modules, which efficiently utilize features extracted from multiple sources and fully capture features of local and global regions. The dual-source fusion network is an encoder designed to extract features from multiple sources such as spectra, synthetic aperture radar, and elevations, which selective fuse features from multiple sources and reduce the interference of redundant features. The local–global transformer module is proposed to capture fine-grained local features and coarse-grained global features, which enables the framework to focus on recognizing multiple-scale objects from the local and global regions. Moreover, we propose a pixelwise contrastive loss, which could encourage that the prediction is pulled closer to the ground truth. The Local–global Framework achieves state-of-the-art performance with 90.45% mean f1 score on the ISPRS Vaihingen dataset and 93.20% mean f1 score on the ISPRS Potsdam dataset.

Developing a multi-period allocation scheme for life-limited hazardous materials is essential to ensure safe and sustainable hazardous material management. In this study, the allocation risk under uncertainty is measured by a type-II fuzzy number, and a bilevel chance constrained programming model is established with the minimum cumulative number of reserve points participating in allocation and the minimum cumulative allocation risk as to the objective functions. Aiming at the multi-dimensional characteristics of multi-period, multi-reserve points, multi-consumption points, and multi-hazardous materials types, and the resource conflict problem in the allocation scheme formulation process, a multi-objective hierarchical differential evolution algorithm with coding repair strategy was designed. By comparing with the classical multi-objective optimization algorithm, the algorithm can search for a more excellent Pareto solution set at the expense of certain time complexity. At the same time, when the decision-maker’s preference is introduced, the method can select a more appropriate multi-period allocation scheme from the perspective of the overall situation and the decision-maker. It provides a reference for determining the rational allocation scheme of resources under the long-term allocation of hazardous materials.

Objective: Acoustic stimulation during sleep is believed to enhance slow waves, which are critical to memory consolidation. However, clinical trials of acoustic stimulation have yielded mixed results concerning its effectiveness in improving human memory. A few studies have implied that acoustic stimulation ameliorates the pathology of Alzheimer’s disease (AD) in mice with normal sleep. Here, we explored the effect of acoustic stimulation on 3xTgAD mice suffering from chronic sleep deprivation, as these data may shed light on the potential use of acoustic stimulation in AD patients with insomnia. Methods: Twenty-four 8-month-old 3xTgAD mice were randomly and equally divided into three groups: the normal sleep group (S group), the sleep deprivation group (SD group), and the acoustic stimulation group (AS group). During a 14-day sleep intervention, the SD and AS groups received 6 h of sleep deprivation per day, and the AS group also received acoustic stimulation in the dark phase. Then, the mice underwent Morris water maze (MWM) tests and arterial spin labelling (ASL) magnetic resonance imaging (MRI) scans and were sacrificed for pathological evaluation. Results: The three groups showed similar stress levels. The S and AS groups exhibited better spatial memory, better brain perfusion, and milder amyloid β (Aβ) and tau pathology than the SD group, although no significant discrepancies were found between the S and AS groups. Conclusions: Acoustic stimulation may exert a protective effect in 3xTgAD mice by improving spatial memory, enhancing the blood supply of the brain, and reversing the contribution of chronic sleep deprivation to Aβ and tau pathology to mimic the effect of normal sleep patterns.

Poly (ADP-ribose) polymerase (PARP) inhibitor olaparib selectively kills cancer cells with BRCA-deficiency and is approved for BRCA-mutated breast, ovarian and pancreatic cancers by FDA. However, phase III study of olaparib failed to show a significant improvement in overall survival in patients with gastric cancer (GC). To discover an effective biomarker for GC patient-selection in olaparib treatment, we analyzed proteomic profiling of 12 GC cell lines. MTA2 was identified to confer sensitivity to olaparib by aggravating olaparib-induced replication stress in cancer cells. Mechanistically, we applied Cleavage Under Targets and Tagmentation assay to find that MTA2 proteins preferentially bind regions of replication origin-associated DNA sequences, which could be enhanced by olaparib treatment. Furthermore, MTA2 was validated here to render cancer cells susceptible to combination of olaparib with ATR inhibitor AZD6738. In general, our study identified MTA2 as a potential biomarker for olaparib sensitivity by aggravating olaparib-induced replication stress.

The laboratory polyethylene wire with different core diameters of 3 mm, 5 mm, 6 mm, 7 mm, 8 mm, 10 mm and 12 mm was used to study the flame spread characteristics. The flame spread could be divided into initial oscillation stage, stable oscillation stage and burn-out stage. With the increase of the copper core diameter, the flame width and flame area increased firstly and then decreased. For wires with intermediate copper core diameters of 6 mm, 7 mm, 8 mm and 10 mm, the relationship between flame area and core diameter was established as A~dc, the total mass loss rate k with the copper core diameter dc followed as k~dc, and the combustion mass loss rate and dripping mass loss rate gradually equaled to each other at stable oscillation stage. By analyzing the temperature field during the process of flame spread, the temperature gradient was almost same for diameters from 3 mm to 10 mm, which demonstrated the radiation heat would be influenced by flame height. Combined with the increased flame spread, the dominant conduction heat transfer mechanism was built. When the diameter was 12 mm, the smaller conduction heat transfer, which illustrated the core material Cu played an cool effect on flame, thus the dominant heat transfer of Cu was changed from a heat source to a heat sink.

The purpose of this study was to evaluate the clinicopathological features of different degrees of extraglomerular renal vascular lesions (RVLs) in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis and explore their clinical determinants. This is a retrospective study of 186 patients with ANCA-associated renal vasculitis diagnosed at the First Affiliated Hospital of Zhengzhou University from January 2014 to April 2019. The patients who met the inclusion criteria were divided into non-renal RVLs, mild RVLs, moderate RVLs, and severe RVLs. It was found that there were significant differences in serum creatinine (SCR), estimated glomerular filtration rate (eGFR), erythrocyte sedimentation rate (ESR), high-density lipoprotein (HDL), systolic blood pressure (SBP), the prevalence rate of hypertension, the proportion of normal glomeruli, and the proportion of sclerotic glomeruli and interstitial fibrosis integral. SCR and ESR are independent risk factors for RVLs. The participants were followed up for 1 year, and the progression to end-stage renal disease (ESRD) and death was defined as endpoint events. We found that the survival rate of patients without RVLs was significantly higher than that of patients with RVLs and that the RVLs were an independent risk factor for ESRD or death. Early intervention in the progression of RVLs can improve the prognosis.

Solanum japonense Nakai. (Solanaceae) is a traditional Chinese medicine and animal fodder in Asian continent. Here, the complete chloroplast genome sequence of S. japonense was determined by the Illumina Hiseq technology. The complete chloroplast genome of S. japonense was 155,415 bp and the GC content was 37.81%. The typical circular quadripartite structure was composed with two inverted repeat (IR) regions with 25,588 bp, a large single-copy (LSC) region (85,931 bp) and a small single-copy (SSC) region (18,344 bp). The chloroplast genome of S. japonense contained 132 unigenes, which contained 86 protein-coding genes, 37 tRNA and 8 rRNA genes and one pseudo-gene. Moreover, 183 SSRs were identified and 65% (119)of them located at LSC region. A Maximum-Likelihood (ML) phylogenetic analysis based on chloroplast genomes indicated that S. japonense was closely related to S.dulcamara, S.nigrum. Our results would provide a valuable resource for resource utilization and the phylogenetic studies of species of Dulcamara sect. in Solanaceae.

Optimizing the aircraft equipment usage scheme of different units according to their task intensity has great significance in improving aircraft reliability and health management. This paper studied the modeling and solving methods of the rotation and echelon usage problems of aircraft equipment measured by dual-life indexes, one of which cannot be controlled. In order to maximize the waste rate of the rotation quantity, echelon uniformity index, life matching index and life utilization index, a decision-making model of the equipment rotation and echelon usage problem under uncertainty was constructed, and an improved NSGA-III with a variable length chromosome was proposed. An improved segmented coding method and operators were proposed, and the repeated individual control mechanism was used to improve the population diversity. When the scale of the problem was large, this method could search a wider range in a short time and obtain more feasible solutions, which verified the feasibility of this method.

In this article, a resonant converter based on a series-parallel self-adjusting rectifier structure is proposed. By changing the driving signal of the switch, the converter has four working modes: full-bridge structure frequency modulation control, full-bridge structure phase-shift control, half-bridge structure frequency modulation control and half-bridge structure phase-shift control. The newly proposed resonant converter retains the soft switching characteristics of the LLC resonant converter and the mode switching can be completed only through software control without adding additional switches. Different modes correspond to different gain ranges. By changing the control strategy of the modes, the newly proposed converter can meet the design requirements of wide output. Finally, an experimental prototype with an input voltage of 25 V and an output voltage of 9 V to 35 V is built. The experimental results prove the correctness of the wide output characteristics of the converter proposed in the article and, in the four operating modes, it can realize zero-voltage turn-on of the active switch on the primary side and zero-current turn-off of the rectifier diode on the secondary side, which preserves the high efficiency of the resonant converter.

The environmental bacterium Pseudomonas mosselii produces antagonistic secondary metabolites with inhibitory effects on multiple plant pathogens, including Ralstonia solanacearum, the causal agent of bacterial wilt. In this study, an engineered P. mosselii strain was generated to express R. solanacearum ripAA, which determines the incompatible interactions with tobacco plants. The ripAA gene, together with its native promoter, was integrated into the P. mosselii chromosome. The resulting strain showed no difference in antimicrobial activity against R. solanacearum. Promoter-LacZ fusion and RT-PCR experiments demonstrated that the ripAA gene was transcribed in culture media. Compared with that of the wild type, the engineered strain reduced the disease index by 9.1% for bacterial wilt on tobacco plants. A transcriptome analysis was performed to identify differentially expressed genes in tobacco plants, and the results revealed that ethylene- and jasmonate-dependent defense signaling pathways were induced. These data demonstrates that the engineered P. mosselii expressing ripAA can improve biological control against tobacco bacterial wilt by the activation of host defense responses.