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303. Accuracy of rapid Helicobacter pylori antigen tests for the surveillance of the updated prevalence of H. pylori in Taiwan

Author

Fang, Yu-Jen, primary, Chen, Mei-Jyh, additional, Chen, Chieh-Chang, additional, Lee, Ji-Yuh, additional, Yang, Tsung-Hua, additional, Yu, Chien-Chun, additional, Chiu, Min-Chin, additional, Kuo, Chia-Chi, additional, Weng, Yu-Jong, additional, Bair, Ming-Jong, additional, Wu, Ming-Shiang, additional, Luo, Jiing-Chyuan, additional, and Liou, Jyh-Ming, additional

Published
2020
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304. Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus

Author

Liou, Jyh-Ming, primary, Malfertheiner, Peter, additional, Lee, Yi-Chia, additional, Sheu, Bor-Shyang, additional, Sugano, Kentaro, additional, Cheng, Hsiu-Chi, additional, Yeoh, Khay-Guan, additional, Hsu, Ping-I, additional, Goh, Khean-Lee, additional, Mahachai, Varocha, additional, Gotoda, Takuji, additional, Chang, Wei-Lun, additional, Chen, Mei-Jyh, additional, Chiang, Tsung-Hsien, additional, Chen, Chieh-Chang, additional, Wu, Chun-Ying, additional, Leow, Alex Hwong-Ruey, additional, Wu, Jeng-Yih, additional, Wu, Deng-Chyang, additional, Hong, Tzu-Chan, additional, Lu, Hong, additional, Yamaoka, Yoshio, additional, Megraud, Francis, additional, Chan, Francis K L, additional, Sung, Joseph JY, additional, Lin, Jaw-Town, additional, Graham, David Y, additional, Wu, Ming-Shiang, additional, and El-Omar, Emad M, additional

Published
2020
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309. Mass eradication ofHelicobacter pylorito reduce gastric cancer incidence and mortality: a long-term cohort study on Matsu Islands

Author

Chiang, Tsung-Hsien, primary, Chang, Wei-Jung, additional, Chen, Sam Li-Sheng, additional, Yen, Amy Ming-Fang, additional, Fann, Jean Ching-Yuan, additional, Chiu, Sherry Yueh-Hsia, additional, Chen, Yi-Ru, additional, Chuang, Shu-Ling, additional, Shieh, Chun-Fu, additional, Liu, Cheng-Ying, additional, Chiu, Han-Mo, additional, Chiang, Hung, additional, Shun, Chia-Tung, additional, Lin, Ming-Wei, additional, Wu, Ming-Shiang, additional, Lin, Jaw-Town, additional, Chan, Chang-Chuan, additional, Graham, David Y, additional, Chen, Hsiu-Hsi, additional, and Lee, Yi-Chia, additional

Published
2020
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310. Risk stratification for gastric cancer after Helicobacter pylori eradication: A population‐based study on Matsu Islands

Author

Chiang, Tsung‐Hsien, primary, Maeda, Masahiro, additional, Yamada, Harumi, additional, Chan, Chang‐Chuan, additional, Chen, Sam Li‐Sheng, additional, Chiu, Sherry Yueh‐Hsia, additional, Chen, Yen‐Nien, additional, Chou, Yi‐Hsuan, additional, Shieh, Chun‐Fu, additional, Liu, Cheng‐Ying, additional, Chiu, Han‐Mo, additional, Chiang, Hung, additional, Shun, Chia‐Tung, additional, Lin, Ming‐Wei, additional, Wu, Ming‐Shiang, additional, Lin, Jaw‐Town, additional, Chen, Hsiu‐Hsi, additional, Ushijima, Toshikazu, additional, Graham, David Y., additional, and Lee, Yi‐Chia, additional

Published
2020
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329. Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium

Author

Jan, Hau-Ming, primary, Chen, Yi-Chi, additional, Yang, Tsai-Chen, additional, Ong, Lih-Lih, additional, Chang, Chia-Chen, additional, Muthusamy, Sasikala, additional, Abera, Andualem Bahiru, additional, Wu, Ming-Shiang, additional, Gervay-Hague, Jacquelyn, additional, Mong, Kwok-Kong Tony, additional, and Lin, Chun-Hung, additional

Published
2020
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332. Allicin Modifies the Composition and Function of the Gut Microbiota in Alcoholic Hepatic Steatosis Mice

Author

Panyod, Suraphan, primary, Wu, Wei-Kai, additional, Lu, Kuan-Hung, additional, Liu, Chun-Ting, additional, Chu, Yung-Lin, additional, Ho, Chi-Tang, additional, Hsiao, Wen-Luan Wendy, additional, Lai, Yi-Syuan, additional, Chen, Wei-Cheng, additional, Lin, Yu-En, additional, Lin, Shi-Hang, additional, Wu, Ming-Shiang, additional, and Sheen, Lee-Yan, additional

Published
2020
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335. Planning mass eradication ofHelicobacter pyloriinfection for indigenous Taiwanese peoples to reduce gastric cancer

Author

Bair, Ming‐Jong, primary, Chuang, Shu‐Lin, additional, Lei, Wei‐Yi, additional, Chen, Chien‐Lin, additional, Tian, Hui‐Wen, additional, Chiang, Tsung‐Hsien, additional, Su, William Wang‐Yu, additional, Lin, Chiu‐Chu, additional, Chung Lo, Yuan‐Ting, additional, Jou, Yann‐Yuh, additional, Wu, Chien‐Yuan, additional, Chia, Shu‐Li, additional, Wu, Ming‐Shiang, additional, Chen, Hsiu‐Hsi, additional, Chu, Chia‐Hsiang, additional, Lee, Yi‐Chia, additional, and Wang, Ying‐Wei, additional

Published
2019
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347. Brand interchangeability of pepsinogen tests in the real-world setting after eradication of Helicobacter pylori: a community-based study.

Author

Chiang, Tsung-Hsien, Chen, Yen-Nien, Chen, Yi-Ru, Tseng, Yu-Hua, Shieh, Chun-Fu, Liu, Cheng-Ying, Chiu, Han-Mo, Chiang, Hung, Shun, Chia-Tung, Wu, Ming-Shiang, Lin, Jaw-Town, and Lee, Yi-Chia

Subjects
HELICOBACTER pylori, PEPSINOGEN, ATROPHIC gastritis, MULTIPLE regression analysis, PRECANCEROUS conditions, HELICOBACTER disease diagnosis, STOMACH tumors, GASTRITIS, ENZYMES, RESEARCH funding, HELICOBACTER diseases
Abstract

Background: Serum pepsinogen (PG) is recommended as a screening test for premalignant gastric lesions. However, real-world evidence demonstrating its applicability and equivalence between different test brands is limited.Methods: Mass screening began in 2018 in a high-risk Taiwanese population after eradication of Helicobacter pylori, with the first stage of two PG tests (GastroPanel®, Helsinki, Finland and LZ-Test®, Tokyo, Japan) and the second stage of endoscopy. A positive test was defined as PG-I < 30 ng/mL or PG-I/II ratio < 3 for GastroPanel® and PG-I ≤ 70 ng/mL and PG-I/II ratio ≤ 3 for LZ-Test®. Index lesions included atrophic gastritis and intestinal metaplasia. Test performance was evaluated based on the participation rate, positivity rate, referral rate, positive predictive value (PPV), and the detection rate.Results: Among 7616 eligible participants, 5117 (67.2%) received PG tests and 284 (5.6%) tested positive. Of those who tested positive, 105 (37.0%) underwent endoscopy. Overall PPVs for atrophic gastritis and intestinal metaplasia were 12.4% and 18.9%, respectively, with detection rates of 2.5 and 3.9 per 1000, respectively. Correlations of numerical measures between tests were high and the agreements of test results were substantial. The PPVs (16.3% vs. 16.3% and 23.8% vs. 21.3%, P = 1.00 and 0.71, respectively), detection rates (2.5 vs. 2.5 and 3.7 vs. 3.3 per 1000, P = 1.00 and 0.27, respectively), and the stage distributions of gastritis were all comparable, which were confirmed by multiple regression analyses.Conclusions: PG testing is effective for mass screening after eradication of H. pylori. Tests from different manufacturers, even using different analytical methods and cutoff criteria, can perform equivalently. [ABSTRACT FROM AUTHOR]

Published
2022
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348. Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation.

Author

Panyod, Suraphan, Wu, Wei-Kai, Chen, Pei-Chen, Chong, Kent-Vui, Yang, Yu-Tang, Chuang, Hsiao-Li, Chen, Chieh-Chang, Chen, Rou-An, Liu, Po-Yu, Chung, Ching-Hu, Huang, Huai-Syuan, Lin, Angela Yu-Chen, Shen, Ting-Chin David, Yang, Kai-Chien, Huang, Tur-Fu, Hsu, Cheng-Chih, Ho, Chi-Tang, Kao, Hsien-Li, Orekhov, Alexander N., and Wu, Ming-Shiang

Published
2022
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349. The efficacy of Lactobacillus acidophilus and rhamnosus in the reduction of bacterial load of Helicobacter pylori and modification of gut microbiota—a double‐blind, placebo‐controlled, randomized trial.

Author

Chen, Mei‐Jyh, Chen, Chieh‐Chang, Huang, Yu‐Chun, Tseng, Chieh‐Chih, Hsu, Jing‐Ting, Lin, Yi‐Fen, Fang, Yu‐Jen, Wu, Ming‐Shiang, and Liou, Jyh‐Ming

Subjects
LACTOBACILLUS acidophilus, GUT microbiome, LACTOBACILLUS rhamnosus, HELICOBACTER pylori, FECAL microbiota transplantation, PROBIOTICS
Abstract

Background: Probiotics may alter the gut microbiota and may reduce antibiotic‐related dysbiosis after H. pylori eradication. However, whether probiotics are effective in reducing the bacterial load of H. pylori and modifying the gut microbiota remains unknown. We aimed to assess the efficacy of Lactobacillus acidophilus and Lactobacillus rhamnosus in reducing the bacterial load of H. pylori and modifying the gut microbiota. Materials and methods: In this double‐blind, randomized, placebo‐controlled trial, we recruited 40 adult subjects with moderate to high bacterial loads of H. pylori, defined as a mean delta over baseline (DOB) value of the 13C‐urea breath test (13C‐UBT) of 10 or greater every 4 days 6 times. Eligible subjects were randomized in a 1:1 ratio to receive either probiotics containing Lactobacillus acidophilus and Lactobacillus rhamnosus or placebo twice daily for 4 weeks. 13C‐UBT was measured weekly from the beginning of treatment to 2 weeks after treatment. Amplification of the V3 and V4 hypervariable regions of the 16S rRNA was performed for fecal microbiota. Results: A total of 40 subjects were randomized to receive probiotics or placebo. The DOB value was significantly lower in the probiotic group than in the placebo group after 4 weeks of treatment (26.0 vs. 18.5, p =.045). The DOB value was significantly reduced compared to that at baseline in the probiotic group (18.5 vs. 26.7, p =.001) but not in the placebo group (26.0 vs. 25.0, p =.648). However, the eradication rate for H. pylori was 0% in both groups. There was no significant difference in the DOB values between the two groups 1 and 2 weeks after discontinuation of the probiotics. There were also no significant changes observed in the α‐diversity and β‐diversity at week 4 compared to baseline in the probiotic group (p =.77 and 0.91) and the placebo group (p =.26 and 0.67). Conclusions: Although the use of Lactobacillus acidophilus and Lactobacillus rhamnosus may reduce the bacterial load of H. pylori, there were no significant changes in the composition of gut microbiota. This trial is registered with ClinicalTrials.gov, NCT02725138. [ABSTRACT FROM AUTHOR]

Published
2021
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