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Objective: This study aims to observe the effect of enrichment rehabilitation (ER) on cognitive function in post-stroke patients and to clarify its underlying mechanism. Methods: Forty patients with post-stroke cognitive impairment (PSCI) meeting the inclusion criteria were randomly assigned to two groups: conventional medical rehabilitation (CM group) and ER intervention (ER group). All patients underwent assessments of overall cognitive function, attention function, and executive function within 24 h before the start of training and within 24 h after the 8 weeks of training. We investigated the altered resting-state functional connectivity (RSFC) with the right dorsolateral prefrontal cortex (DLPFC) in patients with PSCI following ER training through functional magnetic resonance imaging (fMRI). Additionally, twenty people undergoing routine physical examinations in the outpatient department of our hospital were selected as the healthy control (HC) group. Results: Before training, both groups of PSCI patients exhibited significant impairment in overall cognitive function, attention function, and executive function compared to the HC group. However, there was no significant difference between the two PSCI patient groups. Following 8 weeks of treatment, both PSCI patient groups demonstrated substantial improvement in overall cognitive function, attention function, and executive function. Moreover, the ER group exhibited greater improvement after training compared to the CM group. Despite the improvements, the cognitive behavioral performance assessment scores of both PSCI patient groups remained lower than those of the HC group. RSFC analysis in the ER group revealed strengthened positive functional connectivity between the right DLPFC and the left superior frontal gyrus (SFG) and left anterior cingulate gyrus (ACG), along with decreased functional connectivity between the right DLPFC and the right superior temporal gyrus (STG) and right precentral gyrus post-ER intervention. Conclusion: ER intervention is more effective than conventional medical rehabilitation in improving the cognitive function of PSCI patients, potentially by augmenting the FC between the right DLPFC and dominant cognitive brain regions, such as the left SFG and left ACG while attenuating the FC between the right DLPFC and non-dominant hemisphere areas including the STG and precentral gyrus within the right hemisphere. [ABSTRACT FROM AUTHOR]

In the waterway construction projects of the upper reaches of the Yangtze River, crushed mudstone particles are widely used to backfill the foundations of rock-socketed concrete-filled steel tube (RSCFST) piles, a structure widely adopted in port constructions. In these projects, the steel–mudstone interfaces experience complex loading conditions, and the surface profile tends to vary within certain ranges during construction and operation. The changes in boundary conditions and material profile significantly impact the bearing performance of these piles when subjected to cyclic loads, such as ship impacts, water level fluctuations, and wave-induced loads. Therefore, it is necessary to investigate the shear characteristics of the RSCFST pile–soil interface under cyclic vertical loading, particularly in relation to varying deformation levels in the steel casing's outer profile. In this study, a series of cyclic direct shear tests are carried out to investigate the influential mechanisms of roughness on the cyclic behavior of RSCFST pile–soil interfaces. The impacts of roughness on shear stress, shear stiffness, damping ratio, normal stress, and particle breakage ratio are discussed separately and can be summarized as follows: (1) During the initial phase of cyclic shearing, increased roughness correlates with higher interfacial shear strength and anisotropy, but also exacerbates interfacial particle breakage. Consequently, the sample undergoes more significant shear contraction, leading to reduced interfacial shear strength and anisotropy in the later stages. (2) The damping ratio of the rough interface exhibits an initial increase followed by a decrease, while the smooth interface demonstrates the exact opposite trend. The variation in damping ratio characteristics corresponds to the transition from soil–structure to soil–soil interfacial shearing. (3) Shear contraction is more pronounced in rough interface samples compared to the smooth interface, indicating that particle breakage has a greater impact on soil shear contraction compared to densification. [ABSTRACT FROM AUTHOR]