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This study evaluated the risks of childhood acute bronchitis and bronchiolitis (CABs) for children with asthma or allergic rhinitis (AR). Using insurance claims data of Taiwan, we identified, from children of ≤12 years old in 2000–2016, cohorts with and without asthma (N = 192,126, each) and cohorts with and without AR (N = 1,062,903, each) matched by sex and age. By the end of 2016, the asthma cohort had the highest bronchitis incidence, AR and non-asthma cohorts followed, and the lowest in the non-AR cohort (525.1, 322.4, 236.0 and 169.9 per 1000 person-years, respectively). The Cox method estimated adjusted hazard ratios (aHRs) of bronchitis were 1.82 (95% confidence interval (CI), 1.80–1.83) for the asthma cohort and 1.68 (95% CI, 1.68–1.69) for the AR cohort, relative to the respective comparisons. The bronchiolitis incidence rates for these cohorts were 42.7, 29.5, 28.5 and 20.1 per 1000 person-years, respectively. The aHRs of bronchiolitis were 1.50 (95% CI, 1.48–1.52) for the asthma cohort and 1.46 (95% CI, 1.45–1.47) for the AR cohort relative to their comparisons. The CABs incidence rates decreased substantially with increasing age, but were relatively similar for boys and girls. In conclusion, children with asthma are more likely to develop CABs than are children with AR. [ABSTRACT FROM AUTHOR]

Abstract Thiodiglycolic acid (TDGA) is a major metabolite of vinyl chloride monomer (VCM), and it has been suggested as an exposure biomarker for VCM. The validity of this biomarker when the level of VCM is less than 5 ppm, however, is questionable. The objective of this article is to evaluate the feasibility of using urinary TDGA as a biomarker of VCM exposure in a community health risk assessment setting where the concentration of VCM in air is typically very low (likely below 1 ppm). To achieve this objective, we examine the fraction of urinary TDGA associated with different levels of VCM exposures of three studies from different countries, using estimations of the TDGA metabolite predicted by a PBPK model. It is demonstrated that differences in background TDGA have considerable effect on the adequacy of TDGA as a biomarker of VCM. We conclude that, in a community health assessment setting, TDGA should not be used as an exposure biomarker for VCM without having a proper control group, and a PBPK model can be used first to determine whether or not the amount of TDGA in urine is of concern. Highlights • A PBPK model can be used to separate signal (VCM derived) and noise (non-VCM derived) in a urinary TDGA. • TDGA should not be used as an exposure biomarker for VCM without having a proper control group. • A PBPK model can be used first to determine whether or not the amount of TDGA in urine is of concern. [ABSTRACT FROM AUTHOR]

Cigarette smoking is one of the most serious health problems in Taiwan. Although the Taiwanese government passed a Tobacco Hazard Control Act in 1997, it is not fully applicable to the workplace. The purpose of the study was to review workplace smoking prevalence and policies, and to discuss the opportunities and challenges of implementing workplace smoking policies in Taiwan. Results show that smoking prevalence in the workplace in Taiwan is high, particularly among males, ranging from 38 to 68%. More than 75% of smokers in Taiwan smoke in the workplace. The percentage of workplaces implementing restrictive smoking policies in Taiwan is low, particularly in small-sized workplaces. The Tobacco Hazard Control Act in Taiwan has not been strongly enforced in public places, let alone in private companies. Several constructive suggestions are presented in the study. For example, establishing workplace smoking policies, informing employers that secondhand smoke is a human carcinogen, providing financial support for employers to initiate cessation programs, and modifying the current Tobacco Hazard Control Act, etc. [ABSTRACT FROM AUTHOR]

Background: Evidences have shown that the stroke risk associated with long-term exposure to particulate matter with an aerodynamic diameter of ≤2.5 μm (PM 2.5 ) varies among people in North America, Europe and Asia, but studies in Asia rarely evaluated the association by stroke type. We examined whether long-term exposure to PM 2.5 is associated with developing all strokes, ischemic stroke and hemorrhagic stroke., Methods: The retrospective cohort study consisted of 1,362,284 adults identified from beneficiaries of a universal health insurance program in 2011. We obtained data on air pollutants and meteorological measurements from air quality monitoring stations across Taiwan in 2010-2015. Annual mean levels of all environmental measurements in residing areas were calculated and assigned to cohort members. We used Cox proportional hazards models to estimate hazard ratio (HR) and 95% confidence interval (CI) of developing stroke associated with 1-year mean levels of PM 2.5 at baseline in 2010, and yearly mean levels from 2010 to 2015 as the time-varying exposure, adjusting for age, sex, income and urbanization level., Results: During a median follow-up time of 6.0 years, 12,942 persons developed strokes, 9919 (76.6%) were ischemic. The adjusted HRs (95% CIs) per interquartile range increase in baseline 1-year mean PM 2.5 were 1.03 (1.00-1.06) for all stroke, 1.06 (1.02-1.09) for ischemic stroke, and 0.95 (0.89-1.10) for hemorrhagic stroke. The concentration-response curves estimated in the models with and without additional adjustments for other environmental measurements showed a positively linear association between baseline 1-year mean PM 2.5 and ischemic stroke at concentrations greater than 30 μg/m 3 , under which no evidence of association was observed. There was an indication of an inverse association between PM 2.5 and hemorrhagic stroke, but the association no longer existed after controlling for nitrogen dioxide or ozone. We found similar shape of the concentration-response association in the Cox regression models with time-varying PM 2.5 exposures., Conclusion: Long-term exposure to PM 2.5 might be associated with increased risk of developing ischemic stroke. The association with high PM 2.5 concentrations remained significant after adjustment for other environmental factors., (© 2022. The Author(s).)

Objectives: To quantify risk factors for nonoccupational absence from musculoskeletal disorders (MSD) among petroleum-manufacturing employees., Methods: We conducted a 4-year follow-up study including 860 employees with an MSD illness absence of 4 days or longer and 5691 employees with no MSD absence. Odds ratios were calculated using logistic regression., Results: Risk of MSD absence from low back and non-low back disorders was significantly associated with physically demanding job, overweight/obesity, prior absence from MSD, and absence from cardiovascular, respiratory, or mental illness, or accidents during the study period. Smoking also increased risk of low back disorders., Conclusions: Results suggest it is possible to reduce the impact of MSD through integrated safety prevention and health promotion programs including traditional elements of job factor evaluation, training, and ergonomics, but also health counseling and support for weight reduction, smoking cessation, and personal fitness programs.