218 results on '"Treboux A"'
Search Results
202. Existence of posner's cluster in vacuum
- Author
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Pierre Layrolle, Atsuo Ito, Gabin Treboux, Noriko Kanzaki, and Kazuo Onuma
- Subjects
Crystallography ,Oxygen atom ,Chemistry ,Potential energy surface ,Atom ,Cluster (physics) ,Ab initio ,Amorphous calcium phosphate ,Physical and Theoretical Chemistry ,Atomic physics ,Symmetry (physics) ,Single isomer - Abstract
Using ab initio methods, a single isomer of D3h symmetry was found to be preeminent on the Ca3(PO4)2 cluster potential energy surface. This isomer has the distinct feature that each calcium atom is surrounded by four oxygen atoms. We studied the aggregation of this isomer in the [Ca3(PO4)2]n systemwith n being 2 or 3. This gives us an energy reference for analyzing the stability of the so-called Posner's cluster Ca9(PO4)6 which is the core of the actual structural model of amorphous calcium phosphate. Posner's cluster is shown to be significantly stabilized in comparison to the energy reference.
203. Analysis of STM images after atom extractions from the Si(111) 7 × 7 unit cell through a cluster model
- Author
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Masakazu Aono, Tomonobu Nakayama, Gabin Treboux, and Hironaga Uchida
- Subjects
Surface (mathematics) ,Brightness ,Dimer ,Ab initio ,Surfaces, Coatings and Films ,law.invention ,Condensed Matter::Materials Science ,chemistry.chemical_compound ,chemistry ,law ,Vacancy defect ,Atom ,Physics::Atomic and Molecular Clusters ,Materials Chemistry ,Cluster (physics) ,Physics::Atomic Physics ,Physical and Theoretical Chemistry ,Scanning tunneling microscope ,Atomic physics - Abstract
Using an ab initio cluster model, we have investigated the electronic information contained in scanning tunneling microscope (STM) images, which were obtained after atom extraction from the Si(111) 7 × 7 surface. Depending on the position of the created vacancy (corner versus center) and on the number of extracted atoms (single atom versus dimer), we obtain different density maps that permit us to propose a rationalization of the brightness of the spots that are observed in the corresponding experimental STM images. It can be understood by a localization of the surface state near the created atomic vacancy.
204. Angiogenic activity of breast cancer patients' monocytes reverted by combined use of systems modeling and experimental approaches
- Author
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Crespo, Isaac, Guex, Nicolas, Bron, Sylvian, Ifticene-Treboux, Assia, Eveline Faes-Van 'T Hull, Kharoubi, Solange, Liechti, Robin, Werffeli, Patricia, Ibberson, Mark, Francois Majo, Michäel Nicolas, Laurent, Julien, Abhishek Garg, Zaman, Khalil, Hans-Anton Lehr, Stevenson, Brian J, Rüegg, Curzio, Coukos, George, Jean-François Delaloye, Xenarios, Ioannis, and Marie-Agnès Doucey
- Subjects
3. Good health
205. Abstract 2993: Intraductal xenografts model ERα-positive invasive lobular carcinoma of the breast
- Author
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Sflomos, George, Battista, Laura, Aouad, Patrick, De Martino, Fabio, Scabia, Valentina, Stravodimou, Athina, Ayyanan, Ayyakkannu, Ifticene-Treboux, Assia, Bucher, Philipp, Fiche, Maryse, Ambrosini, Giovanna, and Brisken, Cathrin
206. Watodo: Une plateforme web pour trouver et promouvoir ses activités favorites
- Author
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Treboux, Jérome and Treboux, Jérome
- Abstract
Le but de ce projet est de mettre à disposition des baby-boomers, soit des utilisateurs de 50 ans et plus, une plateforme web permettant de rechercher des activités ainsi que de les partager. Cette plateforme a des contraintes spécifiques afin de répondre à leurs buts et besoins, soit une interface agréable et facile d’utilisation. Cependant, la partie design du site web ne fait pas partie du projet. En effet, un graphiste s’occupe de l’aspect présentation des écrans. Pour atteindre le but final, plusieurs étapes ont été réalisées. La première fut l’analyse des plateformes similaires sur le web afin d’éviter certaines erreurs, ainsi que pour s’inspirer de certains points avantageux et indispensables. Il en est ressorti que la plupart des sites web sont très compliqués quant à la disposition des informations. C’est pour cette raison que le focus a été mis sur le design ergonomique des différents écrans de la plateforme WATODO.
207. Watodo: Une plateforme web pour trouver et promouvoir ses activités favorites
- Author
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Treboux, Jérome and Treboux, Jérome
- Abstract
Le but de ce projet est de mettre à disposition des baby-boomers, soit des utilisateurs de 50 ans et plus, une plateforme web permettant de rechercher des activités ainsi que de les partager. Cette plateforme a des contraintes spécifiques afin de répondre à leurs buts et besoins, soit une interface agréable et facile d’utilisation. Cependant, la partie design du site web ne fait pas partie du projet. En effet, un graphiste s’occupe de l’aspect présentation des écrans. Pour atteindre le but final, plusieurs étapes ont été réalisées. La première fut l’analyse des plateformes similaires sur le web afin d’éviter certaines erreurs, ainsi que pour s’inspirer de certains points avantageux et indispensables. Il en est ressorti que la plupart des sites web sont très compliqués quant à la disposition des informations. C’est pour cette raison que le focus a été mis sur le design ergonomique des différents écrans de la plateforme WATODO.
208. Risk factors for positive resection margins of breast cancer tumorectomy specimen following breast-conserving surgery
- Author
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Heiss, Niko, Rousson, Valentin, Ifticene-Treboux, Assia, Lehr, Hans-Anton, Delaloye, Jean-François, Heiss, Niko, Rousson, Valentin, Ifticene-Treboux, Assia, Lehr, Hans-Anton, and Delaloye, Jean-François
- Abstract
Background The aim of the study was to identify risk factors for positive surgical margins in breast-conserving surgery for breast cancer and to evaluate the influence of surgical experience in obtaining complete resection. Methods All lumpectomies for invasive breast carcinoma and ductal carcinoma in situ (DCIS) between April 2008 and March 2010 were selected from the database of a single institution. Re-excision rates for positive margins as well as patient and histopathologic tumor characteristics were analyzed. Surgical experience was staged by pairs made of Resident plus Specialist or Consultant. Two periods were defined. During period A, the majority of operations were performed by Residents under supervision of Specialist or Consultant. During period B, only palpable tumors were operated by Residents. Results The global re-excision rate was 27% (50 of 183 patients). The presence of DCIS increased the risk for positive margins: 60% (nine of 15 patients) in the case of sole DCIS compared to 26% (41 of 160 patients) for invasive cancer (p = 0.005) and 35% (42 of 120 patients) in the case of peritumoral DCIS compared to 11% (seven of 62 patients) in the case of sole invasive cancer (p = 0.001). Re-excision rate decreased from 36% (23 of 64 patients) during period A to 23% (27 of 119 patients) during period B (p = 0.055). There was no significant difference between the surgical pairs. Conclusion In our study, DCIS was the only risk factor for positive surgical margins. Breast-conserving surgery for non-palpable tumors should be performed by Specialists, however, palpable tumors can be safely operated by Residents under supervision.
209. Angiogenic activity of breast cancer patients’ monocytes reverted by combined use of systems modeling and experimental approaches
- Author
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Guex, Nicolas, Crespo, Isaac, Bron, Sylvian, Ifticene-Treboux, Assia, Faes-van’t Hull, Eveline, Kharoubi, Solange, Liechti, Robin, Werffeli, Patricia, Ibberson, Mark, Majo, Francois, Nicolas, Michäel, Laurent, Julien, Garg, Abhishek, Lehr, Khalil Zaman,Hans-Anton, Stevenson, Brian J., Rüegg, Curzio, Coukos, George, Delaloye, Jean-François, Xenarios, Ioannis, Doucey, Marie-Agnès, Guex, Nicolas, Crespo, Isaac, Bron, Sylvian, Ifticene-Treboux, Assia, Faes-van’t Hull, Eveline, Kharoubi, Solange, Liechti, Robin, Werffeli, Patricia, Ibberson, Mark, Majo, Francois, Nicolas, Michäel, Laurent, Julien, Garg, Abhishek, Lehr, Khalil Zaman,Hans-Anton, Stevenson, Brian J., Rüegg, Curzio, Coukos, George, Delaloye, Jean-François, Xenarios, Ioannis, and Doucey, Marie-Agnès
- Abstract
Angiogenesis plays a key role in tumor growth and cancer progression. TIE-2-expressing monocytes (TEM) have been reported to critically account for tumor vascularization and growth in mouse tumor experimental models, but the molecular basis of their pro-angiogenic activity are largely unknown. Moreover, differences in the pro-angiogenic activity between blood circulating and tumor infiltrated TEM in human patients has not been established to date, hindering the identification of specific targets for therapeutic intervention. In this work, we investigated these differences and the phenotypic reversal of breast tumor pro-angiogenic TEM to a weak pro-angiogenic phenotype by combining Boolean modelling and experimental approaches. Firstly, we show that in breast cancer patients the pro-angiogenic activity of TEM increased drastically from blood to tumor, suggesting that the tumor microenvironment shapes the highly pro-angiogenic phenotype of TEM. Secondly, we predicted in silico all minimal perturbations transitioning the highly pro-angiogenic phenotype of tumor TEM to the weak pro-angiogenic phenotype of blood TEM and vice versa. In silico predicted perturbations were validated experimentally using patient TEM. In addition, gene expression profiling of TEM transitioned to a weak pro-angiogenic phenotype confirmed that TEM are plastic cells and can be reverted to immunological potent monocytes. Finally, the relapse-free survival analysis showed a statistically significant difference between patients with tumors with high and low expression values for genes encoding transitioning proteins detected in silico and validated on patient TEM. In conclusion, the inferred TEM regulatory network accurately captured experimental TEM behavior and highlighted crosstalk between specific angiogenic and inflammatory signaling pathways of outstanding importance to control their pro-angiogenic activity. Results showed the successful in vitro reversion of such an activity by perturbation
210. TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer.
- Author
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Bron, Sylvian, Henry, Luc, Faes-van't Hull, Eveline, Turrini, Riccardo, Vanhecke, Dominique, Guex, Nicolas, Ifticene-Treboux, Assia, Marina Iancu, Emanuela, Semilietof, Aikaterini, Rufer, Nathalie, Lehr, Hans-Anton, Xenarios, Ioannis, Coukos, George, Delaloye, Jean-François, and Doucey, Marie-Agnès
- Subjects
BREAST cancer ,MONOCYTES ,ANGIOPOIETIN-2 ,LYMPHATICS ,MACROPHAGES - Abstract
In experimental mouse models of cancer, increasingly compelling evidence point toward a contribution of tumor associated macrophages (TAM) to tumor lymphangiogenesis. Corresponding experimental observations in human cancer remain scarce although lymphatic metastasis is widely recognized as a predominant route for tumor spread. We previously showed that, in malignant tumors of untreated breast cancer (BC) patients, TIE-2-expressing monocytes (TEM) are highly proangiogenic immunosuppressive cells and that TIE-2 and VEGFR signaling pathways drive TEM immunosuppressive function. We report here that, in human BC, TEM express the canonical lymphatic markers LYVE-1, Podoplanin, VEGFR-3 and PROX-1. Critically, both TEM acquisition of lymphatic markers and insertion into lymphatic vessels were observed in tumors but not in adjacent non-neoplastic tissues, suggesting that the tumor microenvironment shapes both TEM phenotype and spatial distribution. We assessed the lymphangiogenic activity of TEM isolated from dissociated primary breast tumorsin vitroandin vivousing endothelial cells (EC) sprouting assay and corneal vascularization assay, respectively. We show that, in addition to their known hemangiogenic function, TEM isolated from breast tumor display a lymphangiogenic activity. Importantly, TIE-2 and VEGFR pathways display variable contributions to TEM angiogenic and lymphangiogenic activities across BC patients; however, combination of TIE-2 and VEGFR kinase inhibitors abrogated these activities and overcame inter-patient variability. These results highlight the direct contribution of tumor TEM to the breast tumor lymphatic network and suggest a combined use of TIE-2 and VEGFR kinase inhibitors as a therapeutic approach to block hem- and lymphangiogenesis in BC. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
211. Beitrag zur katalytischen Oxydation von Toluol
- Author
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Treboux, Jules Maurice
- Subjects
- TOLUOL UND DERIVATE (MONOCYCLISCHE AROMATISCHE KOHLENWASSERSTOFFE), KATALYTISCHE OXIDATION (CHEMISCHE REAKTIONEN), TOLUENE AND DERIVATIVES (MONOCYCLIC AROMATIC HYDROCARBONS), CATALYTIC OXIDATION (CHEMICAL REACTIONS), Chemistry
- Published
- 1934
212. Teen Sexuality
- Author
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Abbott, G.S. and Treboux, D.
- Full Text
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213. Symmetry effects on the conductance of nanotube junctions
- Author
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Treboux, G
- Published
- 1999
- Full Text
- View/download PDF
214. Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1.
- Author
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Sflomos G, Battista L, Aouad P, De Martino F, Scabia V, Stravodimou A, Ayyanan A, Ifticene-Treboux A, Bucher P, Fiche M, Ambrosini G, and Brisken C
- Subjects
- Amino Acid Oxidoreductases genetics, Animals, Extracellular Matrix, Female, Heterografts, Humans, Mice, Receptors, Estrogen, Breast Neoplasms, Carcinoma, Lobular genetics
- Abstract
Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast cancer, typically characterized by loss of E-cadherin. It has clinical features distinct from other estrogen receptor-positive (ER
+ ) breast cancers but the molecular mechanisms underlying its characteristic biology are poorly understood because we lack experimental models to study them. Here, we recapitulate the human disease, including its metastatic pattern, by grafting ILC-derived breast cancer cell lines, SUM-44 PE and MDA-MB-134-VI cells, into the mouse milk ducts. Using patient-derived intraductal xenografts from lobular and non-lobular ER+ HER2- tumors to compare global gene expression, we identify extracellular matrix modulation as a lobular carcinoma cell-intrinsic trait. Analysis of TCGA patient datasets shows matrisome signature is enriched in lobular carcinomas with overexpression of elastin, collagens, and the collagen modifying enzyme LOXL1. Treatment with the pan LOX inhibitor BAPN and silencing of LOXL1 expression decrease tumor growth, invasion, and metastasis by disrupting ECM structure resulting in decreased ER signaling. We conclude that LOXL1 inhibition is a promising therapeutic strategy for ILC., (© 2021 The Authors. Published under the terms of the CC BY 4.0 license.)- Published
- 2021
- Full Text
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215. Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions.
- Author
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Fiche M, Scabia V, Aouad P, Battista L, Treboux A, Stravodimou A, Zaman K, Dormoy V, Ayyanan A, Sflomos G, and Brisken C
- Subjects
- Animals, Breast Neoplasms metabolism, Breast Neoplasms pathology, Carcinoma, Intraductal, Noninfiltrating metabolism, Carcinoma, Intraductal, Noninfiltrating secondary, Female, Heterografts, Humans, Mammary Neoplasms, Experimental metabolism, Mice, SCID, Neoplasm Micrometastasis pathology, Neoplasm Transplantation, Carcinoma, Intraductal, Noninfiltrating pathology, Estrogen Receptor alpha metabolism, Mammary Neoplasms, Experimental pathology
- Abstract
Estrogen receptor α-positive (ER-positive) or 'luminal' breast cancers were notoriously difficult to establish as patient-derived xenografts (PDXs). We and others recently demonstrated that the microenvironment is critical for ER-positive tumor cells; when grafted as single cells into milk ducts of NOD Scid gamma females, >90% of ER-positive tumors can be established as xenografts and recapitulate many features of the human disease in vivo. This intraductal approach holds promise for personalized medicine, yet human and murine stroma are organized differently and this and other species specificities may limit the value of this model. Here, we analyzed 21 ER-positive intraductal PDXs histopathologically. We found that intraductal PDXs vary in extent and define four histopathological patterns: flat, lobular, in situ and invasive, which occur in pure and combined forms. The intraductal PDXs replicate earlier stages of tumor development than their clinical counterparts. Micrometastases are already detected when lesions appear in situ. Tumor extent, histopathological patterns and micrometastatic load correlate with biological properties of their tumors of origin. Our findings add evidence to the validity of the intraductal model for in vivo studies of ER-positive breast cancer and raise the intriguing possibility that tumor cell dissemination may occur earlier than currently thought. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland., (© 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.)
- Published
- 2019
- Full Text
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216. Risk factors for positive resection margins of breast cancer tumorectomy specimen following breast-conserving surgery.
- Author
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Heiss N, Rousson V, Ifticene-Treboux A, Lehr HA, and Delaloye JF
- Subjects
- Breast Neoplasms pathology, Carcinoma, Ductal pathology, Female, Humans, Middle Aged, Neoplasm Invasiveness, Postoperative Complications etiology, Postoperative Complications pathology, Breast Neoplasms surgery, Carcinoma, Ductal surgery, Margins of Excision, Mastectomy, Segmental adverse effects, Postoperative Complications epidemiology
- Abstract
Background The aim of the study was to identify risk factors for positive surgical margins in breast-conserving surgery for breast cancer and to evaluate the influence of surgical experience in obtaining complete resection. Methods All lumpectomies for invasive breast carcinoma and ductal carcinoma in situ (DCIS) between April 2008 and March 2010 were selected from the database of a single institution. Re-excision rates for positive margins as well as patient and histopathologic tumor characteristics were analyzed. Surgical experience was staged by pairs made of Resident plus Specialist or Consultant. Two periods were defined. During period A, the majority of operations were performed by Residents under supervision of Specialist or Consultant. During period B, only palpable tumors were operated by Residents. Results The global re-excision rate was 27% (50 of 183 patients). The presence of DCIS increased the risk for positive margins: 60% (nine of 15 patients) in the case of sole DCIS compared to 26% (41 of 160 patients) for invasive cancer (p = 0.005) and 35% (42 of 120 patients) in the case of peritumoral DCIS compared to 11% (seven of 62 patients) in the case of sole invasive cancer (p = 0.001). Re-excision rate decreased from 36% (23 of 64 patients) during period A to 23% (27 of 119 patients) during period B (p = 0.055). There was no significant difference between the surgical pairs. Conclusion In our study, DCIS was the only risk factor for positive surgical margins. Breast-conserving surgery for non-palpable tumors should be performed by Specialists, however, palpable tumors can be safely operated by Residents under supervision.
- Published
- 2017
- Full Text
- View/download PDF
217. Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer.
- Author
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Van't Hull EF, Bron S, Henry L, Ifticene-Treboux A, Turrini R, Coukos G, Delaloye JF, and Doucey MA
- Abstract
Bone marrow-derived endothelial progenitor cells (EPCs) infiltrate into sites of neovascularization in adult tissues and mature into functional blood endothelial cells (BECs) during a process called vasculogenesis. Human marrow-derived EPCs have recently been reported to display a mixed myeloid and lymphatic endothelial cell (LEC) phenotype during inflammation-induced angiogenesis; however, their role in cancer remains poorly understood. We report the in vitro differentiation of human cord blood CD133
+ CD34+ progenitors into podoplanin+ cells expressing both myeloid markers (CD11b, CD14) and the canonical LEC markers vascular endothelium growth factor receptor 3 (VEGFR-3), lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), and prospero homeobox 1 (PROX-1). These podoplanin+ cells displayed sprouting behavior comparable to that of LECs in vitro and a dual hemangiogenic and lymphangiogenic activity in vivo in an endothelial cell sprouting assay and corneal vascularization assay, respectively. Furthermore, these cells expressed vascular endothelium growth factor (VEGF) family members A, -C, and -D. Thus, bone-marrow derived EPCs stimulate hemangiogenesis and lymphangiogenesis through their ability to differentiate into LECs and to produce angiogenic factors. Importantly, plasma from patients with breast cancer induced differentiation of CD34+ cord blood progenitors into hemangiogenic and lymphangiogenic CD11b+ myeloid cells, whereas plasma from healthy women did not have this effect. Consistent with these findings, circulating CD11b+ cells from breast cancer patients, but not from healthy women, displayed a similar dual angiogenic activity. Taken together, our results show that marrow-derived EPCs become hemangiogenic and lymphangiogenic upon exposure to cancer plasma. These newly identified functions of bone-marrow derived EPCs are expected to influence the diagnosis and treatment of breast cancer.- Published
- 2014
- Full Text
- View/download PDF
218. [Ultrasonography-guided drainage should be considered as the first-line approach for the treatment of breast abscess].
- Author
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Delaloye JF, Capoccia Brugger R, Ifticene Treboux A, Anaye A, and Meuwly JY
- Subjects
- Female, Humans, Abscess therapy, Breast Diseases therapy, Drainage, Ultrasonography, Interventional
- Abstract
The abscesses of the breast are puerperal or non puerperal. The Staphylococcus aureus is the most common germ. The diagnosis is based on clinical criterias and confirmed by the ultrasonography. The percutaneous ultrasonography-guided drainage must be proposed in first intent to treat. Surgical treatment is still valid with a relapsing or chronic abscess, or after the non operative processes have failed.
- Published
- 2010
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