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301. Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts

Author

Mensah, Elsie T., primary, Smyrk, Thomas, additional, Zhang, Lizhi, additional, Bick, Benjamin, additional, Wood-Wentz, Christina M., additional, Buttar, Navtej, additional, Chari, Suresh T., additional, Gleeson, Ferga C., additional, Kendrick, Michael, additional, Levy, Michael, additional, Pearson, Randall, additional, Petersen, Bret T., additional, Vege, Santhi, additional, Enders, Felicity, additional, Limburg, Paul, additional, and Topazian, Mark, additional

Published
2019
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302. Combined Celiac Ganglia and Plexus Neurolysis Shortens Survival, Without Benefit, vs Plexus Neurolysis Alone

Author

Levy, Michael J., primary, Gleeson, Ferga C., additional, Topazian, Mark D., additional, Fujii-Lau, Larissa L., additional, Enders, Felicity T., additional, Larson, Joseph J., additional, Mara, Kristin, additional, Abu Dayyeh, Barham K., additional, Alberts, Steven R., additional, Hallemeier, Christopher L., additional, Iyer, Prasad G., additional, Kendrick, Michael L., additional, Mauck, William D., additional, Pearson, Randall K., additional, Petersen, Bret T., additional, Rajan, Elizabeth, additional, Takahashi, Naoki, additional, Vege, Santhi S., additional, Wang, Kenneth K., additional, and Chari, Suresh T., additional

Published
2019
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303. Classic chronic pancreatitis is associated with prior acute pancreatitis in only 50% of patients in a large single-institution study

Author

Hori, Yasuki, primary, Vege, Santhi Swaroop, additional, Chari, Suresh T., additional, Gleeson, Ferga C., additional, Levy, Michael J., additional, Pearson, Randall K., additional, Petersen, Bret T., additional, Kendrick, Michael L., additional, Takahashi, Naoki, additional, Truty, Mark J., additional, Smoot, Rory L., additional, and Topazian, Mark D., additional

Published
2019
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305. Impact of disconnected pancreatic duct syndrome on endoscopic ultrasound-guided drainage of pancreatic fluid collections.

Author

Wang, Lillian, Elhanafi, Sherif, Storm, Andrew C., Topazian, Mark D., Majumder, Shounak, Abu Dayyeh, Barham K., Levy, Michael J., Petersen, Bret T., Martin, John A., Chari, Suresh T., Vege, Santhi S., and Chandrasekhara, Vinay

Subjects
PANCREATIC duct, ENDOSCOPIC ultrasonography, FLUIDS, ODDS ratio, CONFIDENCE intervals, SYNDROMES, ULTRASONIC imaging, RETROSPECTIVE studies, SURGICAL stents, TREATMENT effectiveness, MEDICAL drainage
Abstract

Background: Endoscopic intervention for pancreatic fluid collections (PFCs) with disconnected pancreatic duct syndrome (DPDS) has been associated with failures and increased need for additional endoscopic and non-endoscopic interventions. The primary aim of this study was to determine the outcomes of endoscopic ultrasound (EUS)-guided transmural drainage of PFCs in patients with DPDS.Methods: In patients undergoing EUS-guided drainage of PFCs from January 2013 to January 2018, demographic profiles, procedural indications and details, adverse events, outcomes, and subsequent interventions were retrospectively collected. Overall treatment success was determined by PFC resolution on follow-up imaging or stent removal without recurrence.Results: EUS-guided drainage of PFCs was performed in 141 patients. DPDS was present in 57 of them (40 %) and walled-off necrosis was the most frequent type of PFC (55 %). DPDS was not associated with lower clinical success, increased number of repeat interventions, or increased time to PFC resolution. Patients with DPDS were more likely to be treated with permanent transmural plastic double-pigtail stents (odds ratio [OR] 6.4; 95 % confidence interval [CI] 2.5 - 16.5; P < 0.001). However, when stents were removed, DPDS was associated with increased PFC recurrence after stent removal (OR 8.0; 95 %CI 1.2 - 381.8; P = 0.04).Conclusions: DPDS frequently occurs in patients with PFCs but does not negatively impact successful resolution. DPDS is associated with increased PFC recurrence after stent removal. [ABSTRACT FROM AUTHOR]

Published
2021
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307. Magnetic resonance imaging as a non-invasive method for the assessment of pancreatic fibrosis (MINIMAP): a comprehensive study design from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer.

Author

Tirkes, Temel, Tirkes, Temel, Yadav, Dhiraj, Conwell, Darwin L, Territo, Paul R, Zhao, Xuandong, Venkatesh, Sudhakar K, Kolipaka, Arunark, Li, Liang, Pisegna, Joseph R, Pandol, Stephen J, Park, Walter G, Topazian, Mark, Serrano, Jose, Fogel, Evan L, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Tirkes, Temel, Tirkes, Temel, Yadav, Dhiraj, Conwell, Darwin L, Territo, Paul R, Zhao, Xuandong, Venkatesh, Sudhakar K, Kolipaka, Arunark, Li, Liang, Pisegna, Joseph R, Pandol, Stephen J, Park, Walter G, Topazian, Mark, Serrano, Jose, Fogel, Evan L, and Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

Abstract

Characteristic features of chronic pancreatitis (CP) may be absent on standard imaging studies. Quantitative Magnetic Resonance Imaging (MRI) techniques such as T1 mapping, extracellular volume (ECV) fraction, diffusion-weighted imaging (DWI) with apparent diffusion coefficient map (ADC), MR elastography (MRE), and T1-weighted signal intensity ratio (SIR) have shown promise for the diagnosis and grading severity of CP. However, radiologists still use the Cambridge classification which is based on traditional ductal imaging alone. There is an urgent need to develop new diagnostic criteria that incorporate both parenchymal and ductal features of CP seen by MRI/MRCP. Designed to fulfill this clinical need, we present the MINIMAP study, which was funded in September 2018 by the National Institutes of Health. This is a comprehensive quantitative MR imaging study which will be performed at multiple institutions in well-phenotyped CP patient cohorts. We hypothesize that quantitative MRI/MRCP features can serve as valuable non-invasive imaging biomarkers to detect and grade CP. We will evaluate the role of T1 relaxometry, ECV, T1-weighted gradient echo SIR, MRE, arteriovenous enhancement ratio, ADC, pancreas volume/atrophy, pancreatic fat fraction, ductal features, and pancreatic exocrine output following secretin stimulation in the assessment of CP. We will attempt to generate a multi-parametric pancreatic tissue fibrosis (PTF) scoring system. We anticipate that a quantitative scoring system may serve as a biomarker of pancreatic fibrosis; hence this imaging technique can be used in clinical practice as well as clinical trials to evaluate the efficacy of agents which may slow the progression or reverse measures of CP.

Published
2019

313. Biomarkers of Chronic Pancreatitis: A systematic literature review.

Author

Cruz-Monserrate, Zobeida, Gumpper, Kristyn, Pita, Valentina, Hart, Phil A., Forsmark, Christopher, Whitcomb, David C., Yadav, Dhiraj, Waldron, Richard T., Pandol, Stephen, Steen, Hanno, Anani, Vincent, Kanwar, Natasha, Vege, Santhi Swaroop, Appana, Savi, Li, Liang, Serrano, Jose, Rinaudo, Jo Ann S., Topazian, Mark, and Conwell, Darwin L.

Abstract

Chronic pancreatitis (CP) does not have diagnostic or prognostic biomarkers. CP is the end stage of a progressive inflammatory syndrome that is diagnosed at late stages by morphologic features. To diagnose earlier stages of the disease, a new mechanistic definition was established based on identifying underlying pathogenic processes and biomarker evidence of disease activity and stage. Although multiple risk factors are known, the corresponding biomarkers needed to make a highly accurate diagnosis of earlier disease stages have not been established. The goal of this study is to systematically analyze the literature to identify the most likely candidates for development into biomarkers of CP. We conducted a systematic review of candidate analytes from easily accessible biological fluids and identified 67 studies that compared CP to nonpancreatic-disease controls. We then ranked candidate biomarkers for sensitivity and specificity by area under the receiver operator curves (AUROCs). Five biomarkers had a large effect size (an AUROC > 0.96), whereas 30 biomarkers had a moderate effect size (an AUROC between 0.96 and 0.83) for distinguishing CP cases from controls or other diseases. However, the studies reviewed had marked variability in design, enrollment criteria, and biospecimen sample handling and collection. Several biomarkers have the potential for evaluation in prospective cohort studies and should be correlated with risk factors, clinical features, imaging studies and outcomes. The Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreas Cancer provides recommendations for avoiding design biases and heterogeneity in sample collection and handling in future studies. [ABSTRACT FROM AUTHOR]

Published
2021
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314. ID: 3526790 ERCP APPROACH FOR PATIENTS WITH A RYGB: A COMPARATIVE RETROSPECTIVE STUDY BETWEEN FOUR ERCP TECHNIQUES WITH PROPOSED MANAGEMENT APPROACH

Author

Ghazi, Rabih, Jaruvongvanich, Veeravich, Baroud, Serge, Vargas, Eric J., Abusaleh, Rami, Mahmoud, Tala, Maselli, Daniel B., Storm, Andrew C., Sawas, Tarek, Kellogg, Todd A., omar ghanem, Levy, Michael J., Topazian, Mark, Law, Ryan, Martin, John A., Petersen, Bret T., Chandrasekhara, Vinay, and Abu Dayyeh, Barham K.

Published
2021
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317. Response

Author

Codipilly, Don C., primary, Qin, Yi, additional, Dawsey, Sanford M., additional, Kisiel, John, additional, Topazian, Mark, additional, Ahlquist, David, additional, and Iyer, Prasad G., additional

Published
2019
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318. Accuracy of Endoscopic Ultrasound Imaging in Distinguishing Celiac Ganglia From Celiac Lymph Nodes

Author

Malikowski, Thomas, primary, Lehrke, Heidi D., additional, Henry, Michael R., additional, Gleeson, Ferga C., additional, Topazian, Mark D., additional, Harmsen, William S., additional, Takahashi, Naoki, additional, Inoue, Dai, additional, Gara, Naveen, additional, Abu Dayyeh, Barham K., additional, Chari, Suresh T., additional, Iyer, Prasad G., additional, Rajan, Elizabeth, additional, Wang, Kenneth K., additional, and Levy, Michael J., additional

Published
2019
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319. Methylated DNA Markers of Esophageal Squamous Cancer and Dysplasia: An International Study.

Author

Yi Qin, Taylor, William, Bamlet, William R., Ravindran, Adharsh, Buglioni, Alessia, Xiaoming Cao, Foote, Patrick H., Slettedahl, Seth W., Mahoney, Douglas W., Albert, Paul S., Sungduk Kim, Nan Hu, Taylor, Philip R., Etemadi, Arash, Sotoudeh, Masoud, Malekzadeh, Reza, Abnet, Christian C., Smyrk, Thomas C., Katzka, David, and Topazian, Mark D.

Abstract

Background: Discovery of methylated DNA markers (MDM) of esophageal squamous cell carcinoma (ESCC) has sparked interest in assessing these markers in tissue. We evaluated MDMs in ESCC from three geographically and ethnically distinct populations, and explored the feasibility of assaying MDMs from DNA obtained by swallowed balloon devices. Methods: MDMs were assayed in ESCC and normal tissues obtained from the populations of United States, Iran, and China, and from exfoliative cytology specimens obtained by balloons in a Chinese population. Areas under the receiver operating curve (AUC) of MDMs discriminating ESCC from normal tissues were calculated. Random forest prediction models were built, trained on U.S. cases and controls, and calibrated to U.S.-only controls (model 1) and three-country controls (model 2). Statistical tests were used to assess the relationship between dysplasia and MDM levels in balloons. Results: Extracted DNA from 333 ESCC and 322 normal tissues was analyzed, in addition to archival DNA from 98 balloons. For ESCC, model 1 validated in Iranian and Chinese tissues with AUCs of 0.90 and 0.87, and model 2 yielded AUCs of 0.99, 0.96, and 0.94 in tissues from the United States, Iran, and China, respectively. In Chinese balloons, MDMs showed a statistically significant trend of increasing levels with increasing grades of dysplasia (P < 0.004). Conclusions: MDMs accurately discriminate ESCC from normal esophagus in tissues obtained from high- and low-incidence countries. Preliminary data suggest that levels of MDMs assayed in DNA from swallowed balloon devices increase with dysplasia grade. Larger studies are needed to validate these results. [ABSTRACT FROM AUTHOR]

Published
2020
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320. Personal Protective Equipment for Endoscopy in Low-Resource Settings During the COVID-19 Pandemic: Guidance From the World Gastroenterology Organisation.

Author

Leddin, Desmond, Armstrong, David, Raja Ali, Raja A., Barkun, Alan, Butt, Amna S., Chen, Ye, Khara, Harshit S., Lee, Yeong Yeh, Leung, Wai Keung, Macrae, Finlay, Makharia, Govind, Malekzadeh, Reza, Makhoul, Elias, Sadeghi, Anahita, Saurin, Jean-Christophe, Topazian, Mark, Thomson, Sandie R., Veitch, Andrew, and Wu, Kaichun

Published
2020
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321. Outcomes of early endoscopic intervention for pancreatic necrotic collections: a matched case-control study.

Author

Oblizajek, Nicholas, Takahashi, Naoki, Agayeva, Sevda, Bazerbachi, Fateh, Chandrasekhara, Vinay, Levy, Michael, Storm, Andrew, Baron, Todd, Chari, Suresh, Gleeson, Ferga C., Pearson, Randall, Petersen, Bret T., Vege, Santhi Swaroop, Lennon, Ryan, Topazian, Mark, and Abu Dayyeh, Barham K.

Abstract

Pancreatic necrosis may be categorized as an acute necrotic collection (ANC) or walled-off necrosis (WON) based on complete encapsulation by a wall and collection age (≤4 weeks or >4 weeks). Endoscopic intervention of WON has become the standard of care, but little is known regarding the safety and efficacy of endoscopic intervention of pancreatic necrosis ≤4 weeks from disease onset. Retrospective review of medical records and imaging studies of all patients undergoing early endoscopic intervention of pancreatic necrosis between 2008 and 2018 was carried out at 1 referral center. Patients who underwent previous interventional treatment were excluded. Control WON patients were matched to early intervention cases. The primary outcome was defined as resolution of the collection after endoscopic treatment, without surgery. Nineteen patients with early intervention were identified. The most common indication for intervention was infection. Median age of these collections at the time of initial endoscopic intervention was 23 days (range, 15-27 days), and all collections had a partial or complete wall discernable on contrast-enhanced CT. Eleven patients underwent concurrent endoscopic necrosectomy. The primary outcome was achieved in all patients in the early intervention group. Total duration of therapy was longer for early intervention compared with controls (103 vs 69 days, P =.042), with no mortality and similar adverse event rates compared with controls. Endoscopic intervention of pancreatic necrosis in the third and fourth weeks of illness appears effective and safe when a partial collection wall is present on cross-sectional imaging studies, with outcomes paralleling those reported for intervention of WON. [ABSTRACT FROM AUTHOR]

Published
2020
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322. Cholangioscopy Biopsies Improve Detection of Cholangiocarcinoma When Combined with Cytology and FISH, but Not in Patients with PSC.

Author

Kaura, Karan, Sawas, Tarek, Bazerbachi, Fateh, Storm, Andrew C., Martin, John A., Gores, Gregory J., Abu Dayyeh, Barham K., Topazian, Mark D., Levy, Michael J., Petersen, Bret T., and Chandrasekhara, Vinay

Subjects
BILIARY tract cancer, CHOLANGIOSCOPY, CYTOLOGY, FISHES, BIOPSY, CLONORCHIS sinensis, RESEARCH, BILE duct tumors, PREDICTIVE tests, CHOLANGIOCARCINOMA, ENDOSCOPIC retrograde cholangiopancreatography, RESEARCH methodology, EARLY detection of cancer, RETROSPECTIVE studies, EVALUATION research, MEDICAL cooperation, BILE duct diseases, COMPARATIVE studies, FLUORESCENCE in situ hybridization, DISEASE complications
Abstract

Background and Aims: Single-operator cholangioscopy (SOC) has been suggested to be a cost-effective strategy for the detection of cholangiocarcinoma (CCA). The aim of this study is to compare the performance characteristics of SOC-guided biopsies and transpapillary biopsies with standard sampling techniques for the detection of CCA.Methods: A retrospective cohort study of patients undergoing SOC between 1/2007 and 10/2018 at a single academic center was performed. Demographic, procedural, and outcomes data were recorded and analyzed using STATA 14.0. Sensitivity comparison between diagnostic tests was performed using exact McNemar test exclusively among patients with CCA. Two-sided p value < 0.05 was considered statistically significant.Results: Ninety-two patients were included; 36 (39.1%) with primary sclerosing cholangitis (PSC), 41 (44.6%) with CCA, and median follow-up was 15.1 months. In the overall cohort, brush cytology demonstrated a sensitivity of 44.7% and increased with the addition of FISH (56.8%; p = 0.12), FISH with SOC-guided biopsy (71.4%; p = 0.03), and FISH with transpapillary biopsy (64.5%; p = 0.01). However, in patients with PSC, there was no significant improvement in sensitivity with the addition of SOC-guided biopsy or transpapillary biopsy in addition to FISH when compared to brush cytology. There was no difference in the rates of overall adverse events (14% vs. 23.2%; p = 0.27) or infection (3% vs. 4%; p = 0.83) in patients with and without PSC.Conclusions: SOC-guided and transpapillary biopsies improve sensitivity for the detection of cholangiocarcinoma in combination with other ERCP-based techniques compared to brush cytology alone. However, while safe, these modalities do not significantly improve the sensitivity for the detection of malignancy in PSC patients. [ABSTRACT FROM AUTHOR]

Published
2020
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323. Rituximab Maintenance Therapy Reduces Rate of Relapse of Pancreaticobiliary Immunoglobulin G4-related Disease

Author

Majumder, Shounak, primary, Mohapatra, Sonmoon, additional, Lennon, Ryan J., additional, Piovezani Ramos, Guilherme, additional, Postier, Neil, additional, Gleeson, Ferga C., additional, Levy, Michael J., additional, Pearson, Randall K., additional, Petersen, Bret T., additional, Vege, Santhi Swaroop, additional, Chari, Suresh T., additional, Topazian, Mark D., additional, and Witzig, Thomas E., additional

Published
2018
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324. The African Esophageal Cancer Consortium: A Call to Action

Author

Van Loon, Katherine, primary, Mwachiro, Michael M., additional, Abnet, Christian C., additional, Akoko, Larry, additional, Assefa, Mathewos, additional, Burgert, Stephen L., additional, Chasimpha, Steady, additional, Dzamalala, Charles, additional, Fleischer, David E., additional, Gopal, Satish, additional, Iyer, Prasad G., additional, Kaimila, Bongani, additional, Kayamba, Violet, additional, Kelly, Paul, additional, Leon, Maria E., additional, Mathew, Christopher G., additional, Menya, Diana, additional, Middleton, Daniel, additional, Mlombe, Yohannie, additional, Mmbaga, Blandina T., additional, Mmbaga, Elia, additional, Mulima, Gift, additional, Murphy, Gwen, additional, Mushi, Beatrice, additional, Mwanga, Ally, additional, Mwasamwaja, Amos, additional, Parker, M. Iqbal, additional, Pritchett, Natalie, additional, Schüz, Joachim, additional, Topazian, Mark D., additional, White, Russell E., additional, McCormack, Valerie, additional, and Dawsey, Sanford M., additional

Published
2018
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325. High-Grade Dysplasia in Resected Main-Duct Intraductal Papillary Mucinous Neoplasm (MD-IPMN) is Associated with an Increased Risk of Subsequent Pancreatic Cancer

Author

Majumder, Shounak, primary, Philip, Nissy A., additional, Singh Nagpal, Sajan Jiv, additional, Takahashi, Naoki, additional, Mara, Kristin C., additional, Kendrick, Michael L., additional, Smyrk, Thomas C., additional, Zhang, Lizhi, additional, Levy, Michael J., additional, Gleeson, Ferga C., additional, Petersen, Bret T., additional, Pearson, Randall K., additional, Topazian, Mark D., additional, Vege, Santhi Swaroop, additional, and Chari, Suresh T., additional

Published
2018
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328. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage

Author

Fisher, William E., primary, Cruz-Monserrate, Zobeida, additional, McElhany, Amy L., additional, Lesinski, Gregory B., additional, Hart, Phil A., additional, Ghosh, Ria, additional, Van Buren, George, additional, Fishman, Douglas S., additional, Rinaudo, Jo Ann S., additional, Serrano, Jose, additional, Srivastava, Sudhir, additional, Mace, Thomas, additional, Topazian, Mark, additional, Feng, Ziding, additional, Yadav, Dhiraj, additional, Pandol, Stephen J., additional, Hughes, Steven J., additional, Liu, Robert Y., additional, Lu, Emily, additional, Orr, Robert, additional, Whitcomb, David C., additional, Abouhamze, Amer S., additional, Steen, Hanno, additional, Sellers, Zachary M., additional, Troendle, David M., additional, Uc, Aliye, additional, Lowe, Mark E., additional, and Conwell, Darwin L., additional

Published
2018
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329. PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies

Author

Yadav, Dhiraj, primary, Park, Walter G., additional, Fogel, Evan L., additional, Li, Liang, additional, Chari, Suresh T., additional, Feng, Ziding, additional, Fisher, William E., additional, Forsmark, Christopher E., additional, Jeon, Christie Y., additional, Habtezion, Aida, additional, Hart, Phil A., additional, Hughes, Steven J., additional, Othman, Mohamed O., additional, Rinaudo, Jo Ann S., additional, Pandol, Stephen J., additional, Tirkes, Temel, additional, Serrano, Jose, additional, Srivastava, Sudhir, additional, Van Den Eeden, Stephen K., additional, Whitcomb, David C., additional, Topazian, Mark, additional, and Conwell, Darwin L., additional

Published
2018
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330. Impact of Biliary Stent Choice on Proton Beam Radiotherapy Dose Distribution

Author

Wang, Xiao Jing, primary, Tryggestad, Erik, additional, Remmes, Nicholas, additional, Hallemeier, Christopher, additional, Beltran, Chris, additional, Kruse, Jon, additional, Haddock, Michael, additional, Garant, Aurelie, additional, Gleeson, Ferga, additional, Rajan, Elizabeth, additional, Levy, Michael, additional, Abu Dayyeh, Barham K., additional, Martin, John, additional, Chandrasekhara, Vinay, additional, Petersen, Bret, additional, Topazian, Mark, additional, and Storm, Andrew C., additional

Published
2018
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335. Risk of Pancreatic Cancer in Patients With Pancreatic Cysts and Family History of Pancreatic Cancer

Author

Mukewar, Saurabh S., primary, Sharma, Ayush, additional, Phillip, Nissy, additional, Gupta, Ridhi, additional, Aryal-Khanal, Anupama, additional, de Pretis, Nicolo, additional, Anani, Vincent, additional, Enders, Felicity T., additional, Larson, Joseph J., additional, Takahashi, Naoki, additional, Levy, Michael J., additional, Topazian, Mark, additional, Pearson, Randall K., additional, Vege, Santhi S., additional, and Chari, Suresh T., additional

Published
2018
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337. Su1426 EUS-GUIDED CORE LIVER BIOPSY USING A 22G FORK-TIP NEEDLE WITH STANDARD SUCTION TECHNIQUE OFFERS A SAFE AND RELIABLE CORE LIVER TISSUE ACQUISITION: A PROSPECTIVE BLINDED TRIAL IN NONALCOHOLIC FATTY LIVER DISEASE

Author

Bazerbachi, Fateh, primary, Vargas, Eric J., additional, Mounajjed, Taofic, additional, Rizk, Monika, additional, Venkatesh, Sudhakar K., additional, Watt, Kymberly D., additional, Gara, Naveen, additional, Hanouneh, Ibrahim, additional, Iyer, Prasad G., additional, Levy, Michael J., additional, Topazian, Mark, additional, Wang, Kenneth K., additional, and Abu Dayyeh, Barham K., additional

Published
2018
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339. Efficacy and Safety of Digital Single-Operator Cholangioscopy for Difficult Biliary Stones

Author

Brewer Gutierrez, Olaya I., primary, Bekkali, Noor L.H., additional, Raijman, Isaac, additional, Sturgess, Richard, additional, Sejpal, Divyesh V., additional, Aridi, Hanaa D., additional, Sherman, Stuart, additional, Shah, Raj J., additional, Kwon, Richard S., additional, Buxbaum, James L., additional, Zulli, Claudio, additional, Wassef, Wahid, additional, Adler, Douglas G., additional, Kushnir, Vladimir, additional, Wang, Andrew Y., additional, Krishnan, Kumar, additional, Kaul, Vivek, additional, Tzimas, Demetrios, additional, DiMaio, Christopher J., additional, Ho, Sammy, additional, Petersen, Bret, additional, Moon, Jong Ho, additional, Elmunzer, B. Joseph, additional, Webster, George J.M., additional, Chen, Yen-I., additional, Dwyer, Laura K., additional, Inamdar, Summant, additional, Patrick, Vanessa B., additional, Attwell, Augustin, additional, Hosmer, Amy, additional, Ko, Christopher, additional, Maurano, Attilio, additional, Sarkar, Avik, additional, Taylor, Linda J., additional, Gregory, Martin H., additional, Strand, Daniel S., additional, Raza, Ali, additional, Kothari, Shivangi, additional, Harris, Jessica P., additional, Kumta, Nikhil A., additional, Manvar, Amar, additional, Topazian, Mark D., additional, Lee, Yun Nah, additional, Spiceland, Clayton M., additional, Trindade, Arvind J., additional, Bukhari, Majidah A., additional, Sanaei, Omid, additional, Ngamruengphong, Saowanee, additional, and Khashab, Mouen A., additional

Published
2018
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341. Su1410 PROSPECTIVE, RANDOMIZED, DOUBLE BLIND CLINICAL TRIAL OF CELIAC PLEXUS NEUROLYSIS AND CELIAC GANGLIA NEUROLYSIS: IMPACT ON PANCREATIC CANCER PAIN, QUALITY OF LIFE, AND SURVIVAL

Author

Levy, Michael J., primary, Gleeson, Ferga C., additional, Topazian, Mark, additional, Fujii-Lau, Larissa L., additional, Enders, Felicity, additional, Larson, Joseph J., additional, Mara, Kristin, additional, Abu Dayyeh, Barham K., additional, Alberts, Steven R., additional, Hallemeier, Christopher, additional, Iyer, Prasad G., additional, Kendrick, Michael L., additional, Mauck, William, additional, Pearson, Randall K., additional, Petersen, Bret T., additional, Rajan, Elizabeth, additional, Takahashi, Naoki, additional, Vege, Santhi Swaroop, additional, Wang, Kenneth K., additional, and Chari, Suresh T., additional

Published
2018
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342. Tu1912 THE ADDITION OF A TUBULAR GASTROPLASTY EXIT TO ENDOSCOPIC TRANSORAL OUTLET REDUCTION (TUBULAR TORE) FOR MANAGEMENT OF WEIGHT REGAIN AFTER ROUX-EN-Y GASTRIC BYPASS ENHANCES OUTCOMES

Author

Vargas, Eric J., primary, Storm, Andrew C., additional, Rizk, Monika, additional, Bazerbachi, Fateh, additional, Acosta, Andres, additional, Mundi, Manpreet, additional, Abu-Lebdeh, H.S., additional, Hurley, Daniel L., additional, Shah, Meera, additional, Collazo-Clavell, Maria L., additional, McKenzie, Travis J., additional, Kendrick, Michael L., additional, Kellogg, Todd A., additional, Topazian, Mark, additional, and Abu Dayyeh, Barham K., additional

Published
2018
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343. 795 IMPACT OF SINGLE FLUID-FILLED INTRAGASTRIC BALLOON ON METABOLIC PARAMETERS AND NONALCOHOLIC STEATOHEPATITIS: A PROSPECTIVE PAIRED ENDOSCOPIC ULTRASOUND GUIDED CORE LIVER BIOPSY AT THE TIME OF BALLOON PLACEMENT AND REMOVAL

Author

Bazerbachi, Fateh, primary, Vargas, Eric J., additional, Mounajjed, Taofic, additional, Venkatesh, Sudhakar K., additional, Watt, Kymberly D., additional, Port, John D., additional, Basu, Rita, additional, Rizk, Monika, additional, Acosta, Andres, additional, Hanouneh, Ibrahim, additional, Gara, Naveen, additional, Shah, Meera, additional, Mundi, Manpreet, additional, Clark, Matthew, additional, Grothe, Karen, additional, Storm, Andrew C., additional, Topazian, Mark, additional, Levy, Michael J., additional, Gostout, Christopher, additional, and Abu Dayyeh, Barham K., additional

Published
2018
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344. Mo1748 - Validation of Novel Methylated DNA Markers for the Detection of Esophageal Squamous Cell Carcinoma and Dysplasia: Multi-National Tissue Study

Author

Iyer, Prasad G., primary, Buglioni, Alessia, additional, Cao, Xiaoming, additional, Foote, Patrick H., additional, Yab, Tracy C., additional, Taylor, William R., additional, Ravindran, Adharsh, additional, Anderson, Bradley W., additional, Lansing, Ramona, additional, Johnson, Michele L., additional, Slettedahl, Seth W., additional, Mahoney, Douglas W., additional, Devens, Mary E., additional, Smyrk, Thomas, additional, Kisiel, John B., additional, Katzka, David A., additional, Topazian, Mark, additional, Hu, Nan, additional, Taylor, Philip R., additional, Etemadi, Arash, additional, Sotoudeh, Masoud, additional, Malekzadeh, Reza, additional, Abnet, Christian C., additional, Dawsey, Sanford, additional, and Ahlquist, David A., additional

Published
2018
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345. 183 - Prospective, Randomized, Double Blind Clinical Trial of Celiac Plexus Neurolysis and Celiac Ganglia Neurolysis for Pancreatic Ductal Adenocarcinoma: Impact of Total Ganglia Volume on Pain, Quality of Life and Survival

Author

Levy, Michael J., primary, Gleeson, Ferga C., additional, Topazian, Mark, additional, Fujii-Lau, Larissa L., additional, Enders, Felicity, additional, Larson, Joseph J., additional, Mara, Kristin, additional, Dayyeh, Barham K. Abu, additional, Alberts, Steven R., additional, Hallemeier, Christopher, additional, Iyer, Prasad G., additional, Kendrick, Michael L., additional, Mauck, William, additional, Pearson, Randall K., additional, Petersen, Bret T., additional, Rajan, Elizabeth, additional, Takahashi, Naoki, additional, Vege, Santhi Swaroop, additional, Wang, Kenneth K., additional, and Chari, Suresh T., additional

Published
2018
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346. Su1347 - The Diagnostic Accuracy of Carcinoembryonic Antigen in Differentiating Mucinous and Non-Mucinous Pancreatic Cystic Neoplasms - A Systematic Review and Individual Patient Data Meta-Analysis

Author

van Huijgevoort, Nadine C.M., primary, Hoogenboom, Sanne A., additional, Lekkerkerker, Selma J., additional, Topazian, Mark, additional, Chandrasekhara, Vinay, additional, Morris-Stiff, Gareth, additional, Al-Haddad, Mohammad A., additional, Oppong, Kofi, additional, Khalid, Asif, additional, Del Chiaro, Marco, additional, Besselink, Marc, additional, and van Hooft, Jeanin E., additional

Published
2018
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348. 388 - Prospective, Randomized, Double Blind Clinical Trial of Celiac Plexus Neurolysis and Celiac Ganglia Neurolysis for Pancreatic Ductal Adenocarcinoma: Impact of Secondary Neurolytic Effects on Pain, Quality of Life, and Survival

Author

Levy, Michael J., primary, Gleeson, Ferga C., additional, Topazian, Mark, additional, Fujii-Lau, Larissa L., additional, Enders, Felicity, additional, Larson, Joseph J., additional, Mara, Kristin, additional, Dayyeh, Barham K. Abu, additional, Alberts, Steven R., additional, Hallemeier, Christopher, additional, Iyer, Prasad G., additional, Kendrick, Michael L., additional, Mauck, William, additional, Pearson, Randall K., additional, Petersen, Bret T., additional, Rajan, Elizabeth, additional, Takahashi, Naoki, additional, Vege, Santhi Swaroop, additional, Wang, Kenneth K., additional, and Chari, Suresh T., additional

Published
2018
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350. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.

Author

Fisher, William E, Fisher, William E, Cruz-Monserrate, Zobeida, McElhany, Amy L, Lesinski, Gregory B, Hart, Phil A, Ghosh, Ria, Van Buren, George, Fishman, Douglas S, Rinaudo, Jo Ann S, Serrano, Jose, Srivastava, Sudhir, Mace, Thomas, Topazian, Mark, Feng, Ziding, Yadav, Dhiraj, Pandol, Stephen J, Hughes, Steven J, Liu, Robert Y, Lu, Emily, Orr, Robert, Whitcomb, David C, Abouhamze, Amer S, Steen, Hanno, Sellers, Zachary M, Troendle, David M, Uc, Aliye, Lowe, Mark E, Conwell, Darwin L, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC), Fisher, William E, Fisher, William E, Cruz-Monserrate, Zobeida, McElhany, Amy L, Lesinski, Gregory B, Hart, Phil A, Ghosh, Ria, Van Buren, George, Fishman, Douglas S, Rinaudo, Jo Ann S, Serrano, Jose, Srivastava, Sudhir, Mace, Thomas, Topazian, Mark, Feng, Ziding, Yadav, Dhiraj, Pandol, Stephen J, Hughes, Steven J, Liu, Robert Y, Lu, Emily, Orr, Robert, Whitcomb, David C, Abouhamze, Amer S, Steen, Hanno, Sellers, Zachary M, Troendle, David M, Uc, Aliye, Lowe, Mark E, Conwell, Darwin L, and Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

Abstract

High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults. Standard operating procedures from the CPDPC centers were evaluated and consolidated. The literature was reviewed for standard biorepository operating procedures that facilitated downstream molecular analysis. The existing literature on biobanking practices was harmonized with the SOPs from the clinical centers to produce a biorepository for pancreatic research. This article reports the methods and basic principles behind the creation of SOPs to develop a biorepository for the CPDPC. These will serve as a guide for investigators developing biorepositories in pancreas research. Rigorous and meticulous adherence to standardized biospecimen collection will facilitate investigations to better understand the pathophysiology and biologic mechanisms of CP, diabetes, and pancreatic cancer.

Published
2018

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