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Hybrid energy systems combine multiple energy sources and storage technologies to enhance performance and meet diverse energy needs. Hybrid heat pump systems are particularly suitable for heating and cooling buildings in rural areas. Air-source heat pumps have two well-known disadvantages during the coldest period of the year, when the building's heating load is at its peak: the heat pump's capacity is reduced and it needs to perform defrost cycles. A potential solution is to size the heat pump to cover only a portion of the peak load and to use a second heat generator in a hybrid heat pump system. There is a gap in the literature regarding the configurational analysis of hybrid heat pump (HHP) systems, particularly in terms of combining heat pumps and biomass boilers, and evaluating their efficiency, economic aspects, and environmental impact. Thus, in this research, a dynamic model of a HHP system, consisting of an air-to-water heat pump paired with a biomass boiler as a backup, is presented. Various configurations of the HHP system have been developed to evaluate key performance indicators, such as efficiency, emissions, operational costs, and other relevant factors. The findings of this paper indicate that the energy performance of HHP systems is significantly affected by the system layout, heat pump size, cut-off temperature, and the control algorithm used to activate the heat generators. Moreover, series operation of HHP systems is not only more efficient than parallel operation but also results in lower emissions and reduced operation costs. As expected, the energy loss associated with defrost cycles significantly impacts the overall performance of a hybrid system based on an air-source heat pump. Finally, the impact of the cut-off temperature on the key parameters in the configuration analysis was examined, and the optimal performance of the HHP system, in terms of minimizing operational costs and emissions, was depicted using a heat map diagram. [ABSTRACT FROM AUTHOR]

AbstractBackgroundMethodsResultsConclusionsTalin-1 (TLN1) is crucial in cell migration, metastasis, and cancer development. This study evaluated Talin-1 expression and its clinical significance in gastric cancer (GC), along with human epidermal growth factor receptor-2 (HER-2) expression and its correlation with Talin-1.Bioinformatics analysis assessed the potential prognostic value of Talin-1 and HER-2 in GC patients. The study included 223 GC patients (Signet Ring Cells and Intestinal subtypes) and 29 non-malignant tissue samples. Immunohistochemistry (IHC) on tissue microarray slides evaluated Talin-1 and HER-2 expression and clinical significance. Receiver operating characteristic (ROC) curves assessed their diagnostic value.Bioinformatics identified Talin-1 as a potential prognostic factor and HER-2 as an oncogene in GC. Talin-1 and HER-2 expression increased in SRC-type GC samples compared to non-malignant tissues. High cytoplasmic Talin-1 expression inversely correlated with tumor expansion and invasion in SRC-type GC. Increased HER-2 expression positively correlated with metastasis. ROC curves showed significant diagnostic values for both proteins.Higher cytoplasmic Talin-1 expression is associated with less invasive tumor behavior, while increased membranous HER-2 expression is associated with metastasis in SRC-type GC. These findings suggest potential use in assessing diagnosis and screening high-risk cancer patients, particularly those with SRC-type GC. [ABSTRACT FROM AUTHOR]

Over the past 30 years, there has been an increasing number of documented human infections associated with the protozoan Lophomonas, specifically Lophomonas blattarum, which is considered a relatively rare infection. These infections are primarily associated with states of immune suppression, including those resulting from corticosteroid therapy. We report a 61‐year‐old female patient with a 20‐year medical history of Systemic lupus erythematosus (SLE) who was admitted due to persistent respiratory symptoms that were unresponsive to treatment. The patient was receiving immunosuppressive therapy for SLE. Upon hospitalization, computed tomography of the lungs revealed the presence of centrilobular nodules exhibiting tree‐in‐bud patterns, as well as bronchiectasis, predominantly in the middle and lower lobes. Subsequently, the patient underwent bronchoscopy, during which a BAL sample was obtained. Microscopic analysis of the sample indicated the presence of L. blattarum. Clinicians often focus on the primary symptoms of SLE, but they must also consider the risk of severe respiratory complications like lophomoniasis. This condition is critical to address in the management of SLE patients, who are immunosuppressed due to the disease's nature and its treatment. [ABSTRACT FROM AUTHOR]

Background: Pulmonary hypertension syndrome (PHS) is a metabolic disorder presenting with cardiopulmonary symptoms. However, garlic powder (GP) is used to treat many diseases, such as heart and lung diseases. Objectives: This study investigated the effects of GP supplementary diet on apoptosis and right ventricle hypertrophy in broiler chickens with PHS. Methods: Ninety meat-type chickens were randomly divided into three groups: Sham, PHS and PHS+GP. The PHS was induced by triiodothyronine (T3) in broiler chickens, and GP was added to the ration after week 1 of rearing (PHS+GP). Then, lung and ventricle tissues were collected at 21 and 49 days of age. PHS was calculated at 21 and 49 days based on the ratio of the right ventricle to the total ventricles (RV/TV) weight index. Gene expression of caspase1 (CASP1) and caspase1 (CASP2) were evaluated by semi-quantitative RT-PCR in the lungs and right heart ventricles. Results: The findings showed that right ventricular hypertrophy increased at day 49 in the PHS group compared to sham (P<0.001), while garlic consumption decreased this ratio to the control level (P<0.05). Also, the expression of CASP1 and CASP2 in the lungs elevated on day 49 (P<0.001), and the GP diet prevented this increase (P<0.05). Moreover, in the right ventricle tissue, PHS affected CASP1 on days 21 and 49, although the expression of CASP2 significantly increased just at day 49 in the PHS group (P<0.001). This increase in both times was weakened by garlic consumption (P<0.05). Conclusion: Consuming garlic as a dietary supplement could prevent PHS by influencing apoptosis in the lung and heart of broilers. [ABSTRACT FROM AUTHOR]

This paper investigates admission procedures of Master of Arts programs of Teaching English as a Foreign Language (MA TEFL) in Iran in comparison with universities around the world. Along with a view of the centralised national MA TEFL entrance exam held in Iran during the past three decades, we investigated admission requirements for comparable graduate programmes of 110 universities in 32 countries and regions. Our qualitative content analysis of this body of data revealed five major categories of admission requirements: Teaching Background, Statement of Purpose, Letter of Recommendation, Interview and Curriculum Vitae. Based on a comparative account of these categories in various universities, we argue that rather than traditional measurement-oriented exams, graduate programmes in general and language education programmes in particular, need to rely on multiple types of admission requirements that provide evidence as to the personal characteristics of applicants, their background and experiences, and their prospects and visions. [ABSTRACT FROM AUTHOR]

Introduction: This study reevaluates the historical origins of occlusion therapy for amblyopia, focusing on the contributions of the 9th-century Islamic scholar, Ali ibn Sahl ibn Rabban al-Tabari (838–870 CE). Methods: The investigation delved into al-Tabari's writings, particularly "Firdous al-Hikma," to extract insights into his approach to addressing reduced vision in one eye.Additionally, the study examined subsequent advancements in occlusion therapy by scholars such as Thabit ibn Qurrah and Rhazes, building upon al-Tabari'sfoundational work. Results: Al-Tabari's reports contain significant insights into occlusion therapy for amblyopia, predating commonly attributed origins of the treatment. Within "Firdous al-Hikma," he outlines methods for addressing reduced vision, advocating for the covering of the healthier eye to promote the function of the weaker eye. These findings highlight the pioneering efforts of al-Tabari and his contemporaries in the Islamic civilization and challenge the conventional narrative surrounding the history of occlusion therapy. Subsequent advancements by scholars such as Thabit ibn Qurrah and Rhazes expanded upon al-Tabari's work, advocating for similar therapeutic approaches within the Islamic civilization. Their contributions further solidified the practice of occlusion therapy, laying the groundwork for its continued evolution and refinement in subsequent centuries. Discussion: Al-Tabari's contributions to occlusion therapy underscore the rich heritage of scientific inquiry in theIslamic civilization during the medieval period. This historical perspective sheds light on the diverse contributions to medical knowledge and practice outside of Western contexts and emphasizes the importance of recognizing and honoring these contributions in the broader history of medicine. [ABSTRACT FROM AUTHOR]

Researchers in the present study planned a reflective teacher education course and documented the contribution of such a course to improving teachers' reflectivity. Five English teachers took part in the reflective teacher education course designed by the researchers. To record how the course could help improve reflective teaching, researchers asked participants to take part in stimulated recall prior to and after the course and to write reflective journals. Thematic analysis of the stimulated recall interviews and journals showed improvements in teachers' reflective teaching as a result of attending the reflective course.

The purpose of the present research is to study the relationship between organizational culture and organizational belonging among employees of Varamin County ministry of education. This is a descriptive-survey study. The statistical population is consisted of all 274 official and contract employees of ministry of education in Varamin County of Tehran province with high school diploma, associate or bachelor's degree or higher. Sampling has been done using relative stratified method. Measurement instruments are: A) organizational culture questionnaire, and B) organizational belonging questionnaire. To assess the validity of the questionnaires the content validity method has been used. To assess their reliability, the questionnaires have been tested on samples of 30 individuals and the Cronbach's Alpha for the questions has been calculated. Cronbach's alpha is 0.91 for organizational culture questionnaire, and 0.85 for organizational belonging questionnaire. These values indicate high reliability for both questionnaires. The results indicate that the prominent dimension of organizational culture in Varamin administration of education is control, and that the employees have moderate organizational belonging. Study of the relationship between dimensions of organizational culture and organizational belonging reveal that there is a significant correlation between organizational belonging and variables of personal innovation, responsibility, leadership, coordination and managerial support. However, no significant correlation has been observed between the variable of control and employees' organizational belonging. Also there is a positive correlation between organizational belonging and variables of organizational identity, reward and punishment system, opposition, and communication pattern in employees of Varamin office of education.

This study aimed to explore the principal's perceptions about, and strategies for, increasing students' active participation in the day-to-day affairs and decision-making at a secondary school located in a rural, mountainous region of Pakistan. By exploring the principal's leadership practices, this study aims to answer the question, 'how can school principals promote students' participation in school leadership and, in turn, how can such participation ultimately lead to a socially just and democratic community?' To us 'school leadership' is not a set of skills or positional authority that lies in one individual -- the principal -- but it is a practice which is widely distributed and engaged by a range of people including students in the day-to-day affairs and business of the school. Although, students' participation in curricular and co-curricular activities and decision-making processes in schools is widely studied elsewhere, there is hardly any study on this topic in the context of Pakistan, particularly with reference to rural schools. Therefore, an empirical investigation based on a qualitative case study method was conducted to collect data from the principal as well as from other members of the school community regarding the leadership practices that promote students' active participation in school affairs. The findings of the study reveal a number of interesting and contextually relevant strategies used by the principal as well as the gaps between his beliefs and practices and the challenges he faces in increasing students' participation in various activities and decisions at the school.

Difficulties with emotion regulation are common in children with autism. Although interventions targeting emotion regulation show promise, children's individual treatment responses vary, and it is important to understand the factors that contribute to treatment change. The present study aimed to identify pre-treatment child characteristics and parent psychopathology that predict treatment response in a 10-week manualized cognitive behaviour therapy intervention for children with autism, 8-12 years of age. Exploratory best-subset regression analyses were first carried out to identify the optimal set of predictors. Logistic regressions were then conducted to determine whether these variables predicted reliable improvement. Outcome variables consisted of the lability/negativity and the emotion regulation subscales of the Emotion Regulation Checklist. Predictors included pre-treatment developmental, clinical, and parent psychopathology variables. Analyses revealed that youth who started the treatment with higher verbal reasoning, higher impairment in social motivation, and more anxious parents were more likely to show reliable improvements in emotion regulation. Youth who started the treatment with higher internalizing scores had lower odds of showing reliable improvement. Implications of our findings include facilitation of active involvement, avoidance of complex language, and the provision of additional supports. Further suggestions to inform clinical practice are discussed.