2,131 results on '"Spies, C."'
Search Results
302. Distales Radioulnargelenk – ein Update
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Spies, C. K., primary and Unglaub, F., additional
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- 2018
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303. Anatomie und Biomechanik des distalen Radioulnargelenks
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Spies, C. K., primary, Langer, M., additional, Müller, L. P., additional, Oppermann, J., additional, Löw, S., additional, and Unglaub, F., additional
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- 2018
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304. Osteoimmunologie – IMMUNOBONE
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Rauner, M., primary, Buttgereit, F., additional, Distler, J., additional, Garbe, A. I., additional, Herrmann, M., additional, Hofbauer, L., additional, Hoffmann, M., additional, Jessberger, R., additional, Kornak, U., additional, Krönke, G., additional, Mundlos, S., additional, Spies, C., additional, Tuckermann, J., additional, and Zwerina, J., additional
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- 2018
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305. Follicular dynamics, circulating progesterone, and fertility in Holstein cows synchronized with reused intravaginal progesterone implants that were sanitized by autoclave or chemical disinfection
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Melo, L.F., primary, Monteiro, P.L.J., additional, Nascimento, A.B., additional, Drum, J.N., additional, Spies, C., additional, Prata, A.B., additional, Wiltbank, M.C., additional, and Sartori, R., additional
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- 2018
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306. Diagnostik und Therapie der degenerativen Diskusläsion
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Löw, S., primary, Spies, C. K., additional, Unglaub, F., additional, Oppermann, J., additional, Langer, M., additional, and Erne, H., additional
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- 2018
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307. Associations of postoperative mortality with the time of day, week and year
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Kork, F., primary, Spies, C., additional, Conrad, T., additional, Weiss, B., additional, Roenneberg, T., additional, Wernecke, K.-D., additional, and Balzer, F., additional
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- 2018
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308. Defektdeckung an den Fingern und am Daumen
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Unglaub, F., primary, Langer, M. F., additional, Unglaub, J. M., additional, Müller, L. P., additional, Hahn, P., additional, Spies, C. K., additional, and Löw, S., additional
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- 2018
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309. Measuring Energy Expenditure in extracorporeal lung support Patients (MEEP) – Protocol, feasibility and pilot trial
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Wollersheim, T., primary, Frank, S., additional, Müller, M.C., additional, Skrypnikov, V., additional, Carbon, N.M., additional, Pickerodt, P.A., additional, Spies, C., additional, Mai, K., additional, Spranger, J., additional, and Weber-Carstens, S., additional
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- 2018
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310. Ligamentäre Verletzungen und Bandinstabilitäten der Fingergelenke
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Spies, C. K., primary, Langer, M., additional, Müller, L. P., additional, Oppermann, J., additional, Löw, S., additional, and Unglaub, F., additional
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- 2017
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311. Delirium, Sedation and Analgesia in the Intensive Care Unit: A Multinational, Two-Part Survey among Intensivists
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Luetz, A, Balzer, F, Radtke, F, Jones, C, Citerio, G, Walder, B, Weiss, B, Wernecke, K, Spies, C, Spies, C., CITERIO, GIUSEPPE, Luetz, A, Balzer, F, Radtke, F, Jones, C, Citerio, G, Walder, B, Weiss, B, Wernecke, K, Spies, C, Spies, C., and CITERIO, GIUSEPPE
- Abstract
Analgesia, sedation and delirium management are important parts of intensive care treatment as they are relevant for patients' clinical and functional long-term outcome. Previous surveys showed that despite this fact implementation rates are still low. The primary aim of the prospective, observational multicenter study was to investigate the implementation rate of delirium monitoring among intensivists. Secondly, current practice concerning analgesia and sedation monitoring as well as treatment strategies for patients with delirium were assesed. In addition, this study compares perceived and actual practice regarding delirium, sedation and analgesia management. Data were obtained with a two-part, anonymous survey, containing general data from intensive care units in a first part and data referring to individual patients in a second part. Questionnaires from 101 hospitals (part 1) and 868 patients (part 2) were included in data analysis. Fifty-six percent of the intensive care units reported to monitor for delirium in clinical routine. Fourty-four percent reported the use of a validated delirium score. In this respect, the survey suggests an increasing use of delirium assessment tools compared to previous surveys. Nevertheless, part two of the survey revealed that in actual practice 73% of included patients were not monitored with a validated score. Furthermore, we observed a trend towards moderate or deep sedation which is contradicting to guideline-recommendations. Every fifth patient was suffering from pain. The implementation rate of adequate pain-assessment tools for mechanically ventilated and sedated patients was low (30%). In conclusion, further efforts are necessary to implement guideline recommendations into clinical practice. The study was registered (ClinicalTrials.gov identifier: NCT01278524) and approved by the ethical committee.
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- 2014
312. Time-resolved fluorescence measurements on solutions of dimethyl-2,6-naphthalenedicarboxylate
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Spies, C. and Gehrke, R.
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- 1999
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313. Structural bone damage in a long-term K/BxN serum-induced arthritis model tends to be attenuated by transgenic disruption of osteoblastic glucocorticoid-signaling
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Wiebe, E, Spies, C, Tu, JW, Maleitzke, T, Zhang, Y, Seibel, M, Zhou, H, Buttgereit, F, Wiebe, E, Spies, C, Tu, JW, Maleitzke, T, Zhang, Y, Seibel, M, Zhou, H, and Buttgereit, F
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- 2017
314. Distal radius fracture of the adult. Diagnostics and therapy
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Unglaub, F., Langer, M. F., Hohendorff, B., Mueller, L. P., Unglaub, J. M., Hahn, P., Krimmer, H., Spies, C. K., Unglaub, F., Langer, M. F., Hohendorff, B., Mueller, L. P., Unglaub, J. M., Hahn, P., Krimmer, H., and Spies, C. K.
- Abstract
Fractures of the distal radius are very common. The majority of patients are elderly females. High impact trauma are often responsible for fractures in young men. Clinical and radiological diagnostics, including computer-assisted tomography (CAT) scan, are generally sufficient. The indication for conservative treatment is still recommended for specific fracture patterns. Application of palmar locking plates after open reduction proved to be efficacious for the majority of fracture patterns. Furthermore, precise detection and treatment of concomitant lesions are mandatory in order to prevent complications.
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- 2017
315. Treatment of digital pyogenic flexor tenosynovitis: single open debridement, irrigation, and primary wound closure followed by antibiotic therapy
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Hohendorff, Bernd, Sauer, H., Biber, F., Franke, J., Spies, C. K., Mueller, L. P., Ries, C., Hohendorff, Bernd, Sauer, H., Biber, F., Franke, J., Spies, C. K., Mueller, L. P., and Ries, C.
- Abstract
Digital pyogenic flexor tenosynovitis requires fast, aggressive treatment. Although this infection occurs frequently, treatment consensus is lacking. Between 2011 and 2015, 22 patients with acute pyogenic flexor tenosynovitis were treated with a single open debridement followed by irrigation; the incision was closed and a 10-day antibiotic course was administered. The average incision-to-suture time was 25 min, and the average hospital stay was 4 days. Recovery was uncomplicated for 20 patients, while two were reoperated, one due to germ resistance and the other due to necrotizing fasciitis. At an average of 30 month postoperatively, 21 of the 22 patients were available for follow-up. The affected finger was inspected, and sensibility, range of motion, and grip force were compared with the opposite side, and the DASH score was determined. Each patient documented pain in the affected finger at rest and during activity, and rated overall satisfaction with the treatment on a visual analogue scale. Almost all patients were free of pain at follow-up and very satisfied. Compared to the contralateral side, each of the affected fingers had the same range of motion and sensibility. Grip force was similar on both sides. The average DASH score was 35 points. A single open debridement with irrigation and primary wound closure followed by 10 days of antibiotic treatment resolved uncomplicated pyogenic flexor tenosynovitis. After 2 and a half years, the treatment yielded high patient satisfaction with neither functional nor subjective impairment of the affected finger.
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- 2017
316. Operative treatment of Dupuytren's contracture.Arthrolysis of the proximal interphalangeal finger joint
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Hohendorff, B., Franke, J., Spies, C. K., Unglaub, F., Mueller, L. P., Ries, C., Hohendorff, B., Franke, J., Spies, C. K., Unglaub, F., Mueller, L. P., and Ries, C.
- Abstract
Background. In the operative treatment of Dupuytren's disease, in certain cases proximal interphalangeal joint flexion contracture remains after fasciectomy due to shrinkage, shortening, and/or adhesion of the periarticular structures. Objectives. How can a residual flexion contracture of the proximal interphalangeal joint after partial fasciectomy in Dupuytren's disease be treated surgically and what follow-up results can be expected? Methods. Description of anatomy, indication, surgical technique of arthrolysis of the proximal interphalangeal joint, postoperative treatment, and critical analysis of the results reported in the literature. Results. Arthrolysis of the proximal interphalangeal joint is performed in up to six consecutive steps. An improvement of only about 50% compared to preoperative flexion contracture can be expected. Conclusion. Despite alleged unsatisfactory results arthrolysis of the proximal interphalangeal joint can be recommended in surgery of Dupuytren's disease. In certain cases, patient cooperation during lengthy postoperative treatment is necessary.
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- 2017
317. Percutaneous needle aponeurotomy for Dupuytren's contracture
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Oppermann, J., Unglaub, F., Mueller, L. P., Loew, S., Hahn, P., Spies, C. K., Oppermann, J., Unglaub, F., Mueller, L. P., Loew, S., Hahn, P., and Spies, C. K.
- Abstract
Dupuytren disease is a benign fibroproliferative disease of the palmar aponeurosis, which can cause considerable functional deficiencies for the person concerned. Partial aponeurectomy is the gold standard in primary surgery. Because it is minimally invasive and has short recovery and low complication rates, the importance of needle aponeurotomy under specific indications has been increasing in the last years. Needle aponeurotomy is a cost-effective treatment with low complication rates. The revision rate compared to partial aponeurectomy is higher. Under consideration of specified indications, needle aponeurotomy is an alternative treatment option.
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- 2017
318. (Partial) fusion of the wrist. Indications and surgical procedures
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Unglaub, F., Langer, M. F., Unglaub, J. M., Sauerbier, M., Mueller, L. P., Krimmer, H., Hahn, P., Spies, C. K., Unglaub, F., Langer, M. F., Unglaub, J. M., Sauerbier, M., Mueller, L. P., Krimmer, H., Hahn, P., and Spies, C. K.
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Carpal bone fusions for secondary reconstruction are still indispensable despite state of the art diagnostic tools and modern treatment techniques for wrist lesions. The former fusions stabilize the wrist and enable sufficient residual carpal mobility. Pain can be reduced significantly by arthrodesis of destroyed joints and the progress of osteoarthritis may be stopped or delayed. This review presents commonly used fusions with their inherent indications, contraindications and complications.
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- 2017
319. Cubital Tunnel Syndrome Diagnostics and Therapy
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Spies, C. K., Loew, S., Langer, M. F., Hohendorff, B., Mueller, L. P., Unglaub, F., Spies, C. K., Loew, S., Langer, M. F., Hohendorff, B., Mueller, L. P., and Unglaub, F.
- Abstract
Cubital tunnel syndrome is the second most common nerve compression syndrome observed in the upper extremity. Mechanical irritation of the ulnar nerve is also found in the upper and the lower arm even though cubital tunnel syndrome is documented most of the time. Apart from clinical examination electrophysiological testing is the most important contributor to the therapy decision. Depending on the clinical manifestation conservative treatment with elbow splinting may be appropriate. In the event of persistent or advanced nerve irritation surgical decompression may be the sensible intervention. Open or endoscopically assisted in situ decompression is currently recommended as the primary intervention while anterior transposition of the ulnar nerve is recommended for revision surgery.
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- 2017
320. Arthrodesis of the distal interphalangeal joint using the headless compression screw
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Spies, C. K., Hohendorff, B., Loew, S., Mueller, L. P., Oppermann, J., Hahn, P., Unglaub, F., Spies, C. K., Hohendorff, B., Loew, S., Mueller, L. P., Oppermann, J., Hahn, P., and Unglaub, F.
- Abstract
Arthrodesis of the distal interphalangeal joint of the fingers and interphalangeal joint of the thumb in order to gain reliable stability and function. Primary and secondary osteoarthritis, rheumatoid arthritis, defect lesions, septic joint destruction, posttraumatic joint deviation, fatal joint instability, fatal tendon lesions. Persistent infections (empyema, osteomyelitis, phlegmon), deficient soft tissue mantle, bone/screw mismatch. Using Beasley's approach the extensor tendon is identified and sectioned. Incision of the collateral ligaments enables good exposition. Precise resection of the joint surfaces. An orthograde guidewire is place into the distal phalanx. After adjustment of the arthrodesis which is controlled using xaEuroray, the guide wire is drilled into the middle phalanx in retrograde fashion. An adequate headless compression screw is introduced via a transverse incision at the fingertip using the guide wire, the former screw is placed until sufficient compression is generated. Finger splint reaching to the proximal interphalangeal joint for 4 weeks after arthrodesis, full weight bearing after 6 weeks. Seventeen patients were examined after arthrodesis of the distal interphalangeal joint using the headless compression screw. The arthrodesis proved to be reliable and safe with a low complication rate and a good functional outcome. The modified Mayo Wrist Score (MMWS) was on average 89 (range 55-100); the outcome parameter DASH (disabilities of arm, shoulder and hand) score was on average 27 (range 1-60).
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- 2017
321. Arthrodesis of the proximal interphalangeal joint of fingers with tension band wire
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Hohendorff, B., Franke, J., Spies, C. K., Mueller, L. P., Ries, C., Hohendorff, B., Franke, J., Spies, C. K., Mueller, L. P., and Ries, C.
- Abstract
Arthrodesis of the proximal interphalangeal joint of fingers in a functional and pain-free position. Primary and secondary osteoarthritis, traumatic joint destruction, posttraumatic malposition, instability, joint destruction due to infection, irreparable extensor and/or flexor tendon lesion, recurrent flexion deformity in Dupuytren's disease, arthritis (e. g., rheumatoid arthritis, psoriatic arthritis), failed resection arthroplasty, failed prosthesis, congenital disorder (e. g., camptodactyly). Persistent joint infection. Resection of the proximal phalanx head and the middle phalanx base, arthrodesis with figure-of-eight tension band wire in a functional position. Plaster of Paris cast with arthrodesis position of the affected finger and intrinsic plus position of at least one adjacent finger for 2 weeks, custom-made finger splint for 4 weeks. A total of 15 of 16 patients with an arthrodesis of the proximal interphalangeal finger joint of the dominant hand by tension band wire were followed up after an average of 31 months. None was affected by the arthrodesis in everyday live. All patients were very satisfied with the result. Nine of 15 patients were free of pain both at rest and with activity. The average DASH score was 48 points. Grip strength averaged 29 kg, 7 % stronger than the contralateral hand.
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- 2017
322. Postoperative treatment of finger joint prostheses
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Hohendorff, B., Vollmers, S., Behrendt, M., Unglaub, F., Spies, C. K., Mueller, L. P., Ries, C., Hohendorff, B., Vollmers, S., Behrendt, M., Unglaub, F., Spies, C. K., Mueller, L. P., and Ries, C.
- Abstract
Background. Artificial joint replacement is a treatment option for osteoarthritis of a metacarpophalangeal or a proximal interphalangeal finger joint. No general guidelines for postoperative treatment of finger joint prostheses exist. However, individualized postoperative treatment involving consistent, close cooperation with the patient and between the surgeon and therapist is required for a good outcome. Methods. We address several aspects of the postoperative treatment of metacarpophalangeal and proximal interphalangeal finger joint prosthesis implantation, which include edema/swelling, scarring, hand therapy, and splinting, and review indications for postoperative treatment of patients. In addition we describe and discuss current treatment concepts and results of metacarpophalangeal and proximal interphalangeal finger joint prostheses. Results. Even with appropriate treatment following implantation of a finger joint prosthesis, postoperative range of motion improves only slightly. However, pain is significantly reduced and outcome evaluation questionnaire scores improve compared to preoperative values. Conclusion. For a good outcome of a finger joint prosthesis, postoperative attention to edema/swelling, scarring, hand therapy, and splinting is essential. Postoperative treatment of a finger joint prosthesis should follow guidelines but be individually adapted to the approach to the joint, the type of prosthesis, the quality of bone and stability of the soft tissue of the finger, the patient's compliance, and the availability of a qualified therapist.
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- 2017
323. Langfristige funktionelle & subjektive Ergebnisse nach endoskopisch assistierter Dekompression des Nervus ulnaris
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Spies, C, Schäfer, M, Bruckner, T, Müller, LP, Hahn, P, Unglaub, F, Spies, C, Schäfer, M, Bruckner, T, Müller, LP, Hahn, P, and Unglaub, F
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- 2017
324. Quality indicators in intensive care medicine for Germany - third edition 2017
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Kumpf, O, Braun, JP, Brinkmann, A, Bause, H, Bellgardt, M, Bloos, F, Dubb, R, Greim, C, Kaltwasser, A, Marx, G, Riessen, R, Spies, C, Weimann, J, Wöbker, G, Muhl, E, Waydhas, C, Kumpf, O, Braun, JP, Brinkmann, A, Bause, H, Bellgardt, M, Bloos, F, Dubb, R, Greim, C, Kaltwasser, A, Marx, G, Riessen, R, Spies, C, Weimann, J, Wöbker, G, Muhl, E, and Waydhas, C
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Quality improvement in medicine is depending on measurement of relevant quality indicators. The quality indicators for intensive care medicine of the German Interdisciplinary Society of Intensive Care Medicine (DIVI) from the year 2013 underwent a scheduled evaluation after three years. There were major changes in several indicators but also some indicators were changed only minimally. The focus on treatment processes like ward rounds , management of analgesia and sedation , mechanical ventilation and weaning , as well as the number of 10 indicators were not changed. Most topics remained except for early mobilization which was introduced instead of hypothermia following resuscitation . Infection prevention was added as an outcome indicator. These quality indicators are used in the peer review in intensive care, a method endorsed by the DIVI. A validity period of three years is planned for the quality indicators., Qualitätsverbesserung in der Medizin hängt von der Messung relevanter Qualitätsindikatoren ab. Die Qualitätsindikatoren für die Intensivmedizin der Deutschen Interdisziplinären Vereinigung für Intensivmedizin (DIVI) aus dem Jahre 2013 sind nun planmäßig nach drei Jahren überarbeitet und angepasst worden. Hierbei gab es deutliche Änderungen in einigen Indikatoren während einige nur minimal verändert wurden. Der Fokus auf intensivmedizinische Behandlungsprozesse wie interprofessionelle Visiten , Management von Analgesie und Sedierung , Beatmung und Weaning blieb ebenso bestehen wie die Gesamtzahl von 10 Indikatoren. Die Themenschwerpunkte blieben weitgehend bestehen außer der Frühmobilisation , welche anstatt der Hypothermie nach Reanimation eingeführt wurde. Infektionsprävention wurde als Ergebnisindikator hinzugefügt. Diese Qualitätsindikatoren werden im Peer Review Prozess der DIVI eingesetzt. Eine Gültigkeitsdauer von drei Jahren ist für diese Qualitätsindikatoren geplant.
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- 2017
325. Transition from in-hospital ventilation to home ventilation: process description and quality indicators
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Kastrup, M, Tittmann, B, Sawatzki, T, Gersch, M, Vogt, C, Rosenthal, M, Rosseau, S, Spies, C, Kastrup, M, Tittmann, B, Sawatzki, T, Gersch, M, Vogt, C, Rosenthal, M, Rosseau, S, and Spies, C
- Abstract
The current demographic development of our society results in an increasing number of elderly patients with chronic diseases being treated in the intensive care unit. A possible long-term consequence of such a treatment is that patients remain dependent on certain invasive organ support systems, such as long-term ventilator dependency. The main goal of this project is to define the transition process between in-hospital and out of hospital (ambulatory) ventilator support. A further goal is to identify evidence-based quality indicators to help define and describe this process.This project describes an ideal sequence of processes (process chain), based on the current evidence from the literature. Besides the process chain, key data and quality indicators were described in detail. Due to the limited project timeline, these indicators were not extensively tested in the clinical environment.The results of this project may serve as a solid basis for proof of feasibility and proof of concept investigations, optimize the transition process of ventilator-dependent patients from a clinical to an ambulatory setting, as well as reduce the rate of emergency re-admissions., Durch die demographische Entwicklung bedingt werden zunehmend ältere Patienten mit chronischen Begleiterkrankungen intensivmedizinisch versorgt. Als eine mögliche Folge einer solchen Intensivbehandlung kann bei diesen Patienten eine chronische Abhängigkeit von apparativen Organersatzverfahren resultieren, welche im Bereich der Beatmung in einer Langzeitbeatmung resultiert. Ziel dieses durch das BMBF geförderte Projekt "Beatmungspflege@home" ist die Definition des Überleitprozesses von der klinischen Beatmung in die außerklinische Beatmung und die Entwicklung von evidenzbasierten Qualitätsindikatoren um diesen Prozess der Überleitung transparent darzustellen. Im Projektverlauf wurde eine Soll-Prozesskette, unter Berücksichtigung der aktuellen Literatur in Bezug auf die Evidenzlage, erstellt. Anhand dieser Soll-Prozesskette wurden parallel die Kennzahlen und Qualitätsindikatoren detailliert definiert und konsentiert. Aus Gründen der begrenzten Projektlaufzeit konnte kein ausführlicher Feldtest zur Evaluation der Praxistauglichkeit durchgeführt werden. Die Projektbeteiligten hoffen, dass die Ergebnisse des Projektes eine solide Grundlage darstellen, um im Anschlussprojekt einen "proof of concept" untersuchen zu können, um damit den Überleitprozess in die außerklinische Beatmung qualitativ zu verbessern und somit unnötige Klinikeinweisungen zu verhindern.
- Published
- 2017
326. Funktionalität nach arthroskopischem Debridement von TFCC 2C Läsionen
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Spies, C, Möldner, M, Unglaub, F, Müller, LP, Bruckner, T, and Hahn, P
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Fragestellung: Untersuchung der subjektiven und funktionellen Parameter nach arthroskopischem Debridement von TFCC 2C Läsionen und die Korrelation dieser Parameter zur Ellenlänge. Methodik: 50 Patienten (15 Männer; 35 Frauen; Durchschnittsalter 47 Jahre) mit TFCC 2C Läsionen[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2016)
- Published
- 2016
- Full Text
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327. Experimentelle Untersuchung zur transossären Refixation der radioulnaren Ligamente
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Spies, C, Niehoff, A, Unglaub, F, Müller, LP, Langer, M, Neiss, W, and Oppermann, J
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine ,distales Radioulnargelenk - Abstract
Fragestellung: Hypothese: Die Refixation der tiefen und oberflächlichen radioulnaren Ligamente ist stabiler als die alleinige Refixation der tiefen Ligamente. Methodik: 14 Oberarm Frischpräparate wurden für die biomechanische Testung verwandt. Die transossäre Refixation der [zum vollständigen Text gelangen Sie über die oben angegebene URL], 57. Kongress der Deutschen Gesellschaft für Handchirurgie
- Published
- 2016
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328. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
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Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Arozena, A. A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., Adhihetty, P. J., Adler, S. G., Agam, G., Agarwal, R., Aghi, M. K., Agnello, M., Agostinis, P., Aguilar, P. V., Aguirre-Ghiso, J., Airoldi, E. M., Ait-Si-Ali, S., Akematsu, T., Akporiaye, E. T., Al-Rubeai, M., Albaiceta, G. M., Albanese, C., Albani, D., Albert, M. L., Aldudo, J., Algül, H., Alirezaei, M., Alloza, I., Almasan, A., Almonte-Beceril, M., Alnemri, E. S., Alonso, C., Altan-Bonnet, N., Altieri, D. C., Alvarez, S., Alvarez-Erviti, L., Alves, S., Amadoro, G., Amano, A., Amantini, C., Ambrosio, S., Amelio, I., Amer, A. O., Amessou, M., Amon, A., An, Z., Anania, F. A., Andersen, S. U., Andley, U. P., Andreadi, C. K., Andrieu-Abadie, N., Anel, A., Ann, D. K., Anoopkumar-Dukie, S., Antonioli, M., Aoki, H., Apostolova, N., Aquila, S., Aquilano, K., Araki, K., Arama, E., Aranda, A., Araya, J., Arcaro, A., Arias, E., Arimoto, H., Ariosa, A. R., Armstrong, J. L., Arnould, T., Arsov, I., Asanuma, K., Askanas, V., Asselin, E., Atarashi, R., Atherton, S. S., Atkin, J. D., Attardi, L. D., Auberger, P., Auburger, G., Aurelian, L., Autelli, R., Avagliano, L., Avantaggiati, M. L., Avrahami, L., Azad, N., Awale, S., Bachetti, T., Backer, J. M., Bae, D. -H., Bae, J. -S., Bae, O. -N., Bae, S. H., Baehrecke, E. H., Baek, S. -H., Baghdiguian, S., Bagniewska-Zadworna, A., Bai, H., Bai, J., Bai, X. -Y., Bailly, Y., Balaji, K. N., Balduini, W., Ballabio, A., Balzan, R., Banerjee, R., Bánhegyi, G., Bao, H., Barbeau, B., Barrachina, M. D., Barreiro, E., Bartel, B., Bartolomé, A., Bassham, D. C., Bassi, M. T., Bast, R. C., J, R., Basu, A., Batista, M. T., Batoko, H., Battino, M., Bauckman, K., Baumgarner, B. L., Bayer, K. U., Beale, R., Beaulieu, J. -F., Beck, G. R., Becker, C., Beckham, J. D., Bédard, P. -A., Bednarski, P. J., Begley, T. J., Behl, C., Behrends, C., Behrens, G. M. N., Behrns, K. 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Murat, Ke, Po-Yuan, Ke, Zun-Ji, Kehrl, John H., Keller, Kate E., Kemper, Jongsook Kim, Kenworthy, Anne K., Kepp, Oliver, Kern, Andrea, Kesari, Santosh, Kessel, David, Ketteler, Robin, Kettelhut, Isis do Carmo, Khambu, Bilon, Khan, Muzamil Majid, Khandelwal, Vinoth K.M., Khare, Sangeeta, Kiang, Juliann G., Kiger, Amy A., Kihara, Akio, Kim, Arianna L., Kim, Cheol Hyeon, Kim, Deok Ryong, Kim, Do-Hyung, Kim, Eung Kweon, Kim, Hye Young, Kim, Hyung-Ryong, Kim, Jae-Sung, Kim, Jeong Hun, Kim, Jin Cheon, Kim, Jin Hyoung, Kim, Kwang Woon, Kim, Michael D., Kim, Moon-Moo, Kim, Peter K., Kim, Seong Who, Kim, Soo-Youl, Kim, Yong-Sun, Kim, Yonghyun, Kimchi, Adi, Kimmelman, Alec C., Kimura, Tomonori, King, Jason S., Kirkegaard, Karla, Kirkin, Vladimir, Kirshenbaum, Lorrie A., Kishi, Shuji, Kitajima, Yasuo, Kitamoto, Katsuhiko, Kitaoka, Yasushi, Kitazato, Kaio, Kley, Rudolf A., Klimecki, Walter T., Klinkenberg, Michael, Klucken, Jochen, Knævelsrud, Helene, Knecht, Erwin, Knuppertz, Laura, Ko, Jiunn-Liang, Kobayashi, Satoru, Koch, Jan C., Koechlin-Ramonatxo, Christelle, Koenig, Ulrich, Koh, Young Ho, Köhler, Katja, Kohlwein, Sepp D., Koike, Masato, Komatsu, Masaaki, Kominami, Eiki, Kong, Dexin, Kong, Hee Jeong, Konstantakou, Eumorphia G., Kopp, Benjamin T., Korcsmaros, Tama, Korhonen, Laura, Korolchuk, Viktor I., Koshkina, Nadya V., Kou, Yanjun, Koukourakis, Michael I., Koumenis, Constantino, Kovács, Attila L., Kovács, Tibor, Kovacs, Werner J., Koya, Daisuke, Kraft, Claudine, Krainc, Dimitri, Kramer, Helmut, Kravic-Stevovic, Tamara, Krek, Wilhelm, Kretz-Remy, Carole, Krick, Roswitha, Krishnamurthy, Malathi, Kriston-Vizi, Jano, Kroemer, Guido, Kruer, Michael C., Kruger, Rejko, Ktistakis, Nicholas T., Kuchitsu, Kazuyuki, Kuhn, Christian, Kumar, Addanki Pratap, Kumar, Anuj, Kumar, Ashok, Kumar, Deepak, Kumar, Dhiraj, Kumar, Rakesh, Kumar, Sharad, Kundu, Mondira, Kung, Hsing-Jien, Kuno, Atsushi, Kuo, Sheng-Han, Kuret, Jeff, Kurz, Tino, Kwok, Terry, Kwon, Taeg Kyu, Kwon, Yong Tae, Kyrmizi, Irene, La Spada, Albert R., Lafont, Frank, Lahm, Tim, Lakkaraju, Aparna, Lam, Truong, Lamark, Trond, Lancel, Steve, Landowski, Terry H., Lane, Darius J.R., Lane, Jon D., Lanzi, Cinzia, Lapaquette, Pierre, Lapierre, Louis R., Laporte, Jocelyn, Laukkarinen, Johanna, Laurie, Gordon W., Lavandero, Sergio, Lavie, Lena, Lavoie, Matthew J., Law, Betty Yuen Kwan, Law, Helen Ka-Wai, Law, Kelsey B., Layfield, Robert, Lazo, Pedro A., Le Cam, Laurent, Le Roch, Karine G., Le Stunff, Hervé, Leardkamolkarn, Vijittra, Lecuit, Marc, Lee, Byung-Hoon, Lee, Che-Hsin, Lee, Erinna F., Lee, Gyun Min, Lee, He-Jin, Lee, Hsinyu, Lee, Jae Keun, Lee, Jongdae, Lee, Ju-Hyun, Lee, Jun Hee, Lee, Michael, Lee, Myung-Shik, Lee, Patty J., Lee, Sam W., Lee, Seung-Jae, Lee, Shiow-Ju, Lee, Stella Y., Lee, Sug Hyung, Lee, Sung Sik, Lee, Sung-Joon, Lee, Sunhee, Lee, Ying-Ray, Lee, Yong J., Lee, Young H., Leeuwenburgh, Christiaan, Lefort, Sylvain, Legouis, Renaud, Lei, Jinzhi, Lei, Qun-Ying, Leib, David A., Leibowitz, Gil, Lekli, Istvan, Lemaire, Stéphane D., Lemasters, John J., Lemberg, Marius K., Lemoine, Antoinette, Leng, Shuilong, Lenz, Guido, Lenzi, Paola, Lerman, Lilach O., Barbato, Daniele Lettieri, Leu, Julia I. 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Sue, Menna-Barreto, Rubem F.S., Menon, Manoj B., Meraz-Ríos, Marco A., Merla, Giuseppe, Merlini, Luciano, Merlot, Angelica M., Meryk, Andrea, Meschini, Stefania, Meyer, Joel N., Mi, Man-Tian, Miao, Chao-Yu, Micale, Lucia, Michaeli, Simon, Michiels, Carine, Migliaccio, Anna Rita, Mihailidou, Anastasia Susie, Mijaljica, Dalibor, Mikoshiba, Katsuhiko, Milan, Enrico, Miller-Fleming, Leonor, Mills, Gordon B., Mills, Ian G., Minakaki, Georgia, Minassian, Berge A., Ming, Xiu-Fen, Minibayeva, Farida, Minina, Elena A., Mintern, Justine D., Minucci, Saverio, Miranda-Vizuete, Antonio, Mitchell, Claire H., Miyamoto, Shigeki, Miyazawa, Keisuke, Mizushima, Noboru, Mnich, Katarzyna, Mograbi, Baharia, Mohseni, Simin, Moita, Luis Ferreira, Molinari, Marco, Molinari, Maurizio, Møller, Andreas Buch, Mollereau, Bertrand, Mollinedo, Faustino, Mongillo, Marco, Monick, Martha M., Montagnaro, Serena, Montell, Craig, Moore, Darren J., Moore, Michael N., Mora-Rodriguez, Rodrigo, Moreira, Paula I., Morel, Etienne, Morelli, Maria Beatrice, Moreno, Sandra, Morgan, Michael J., Moris, Arnaud, Moriyasu, Yuji, Morrison, Janna L., Morrison, Lynda A., Morselli, Eugenia, Moscat, Jorge, Moseley, Pope L., Mostowy, Serge, Motori, Elisa, Mottet, Deni, Mottram, Jeremy C., Moussa, Charbel E.-H., Mpakou, Vassiliki E., Mukhtar, Hasan, Levy, Jean M. Mulcahy, Muller, Sylviane, Muñoz-Moreno, Raquel, Muñoz-Pinedo, Cristina, Münz, Christian, Murphy, Maureen E., Murray, James T., Murthy, Aditya, Mysorekar, Indira U., Nabi, Ivan R., Nabissi, Massimo, Nader, Gustavo A., Nagahara, Yukitoshi, Nagai, Yoshitaka, Nagata, Kazuhiro, Nagelkerke, Anika, Nagy, Péter, Naidu, Samisubbu R., Nair, Sreejayan, Nakano, Hiroyasu, Nakatogawa, Hitoshi, Nanjundan, Meera, Napolitano, Gennaro, Naqvi, Naweed I., Nardacci, Roberta, Narendra, Derek P., Narita, Masashi, Nascimbeni, Anna Chiara, Natarajan, Ramesh, Navegantes, Luiz C., Nawrocki, Steffan T., Nazarko, Taras Y., Nazarko, Volodymyr Y., Neill, Thoma, Neri, Luca M., Netea, Mihai G., Netea-Maier, Romana T., Neves, Bruno M., Ney, Paul A., Nezis, Ioannis P., Nguyen, Hang T.T., Nguyen, Huu Phuc, Nicot, Anne-Sophie, Nilsen, Hilde, Nilsson, Per, Nishimura, Mikio, Nishino, Ichizo, Niso-Santano, Mireia, Niu, Hua, Nixon, Ralph A., Njar, Vincent C.O., Noda, Takeshi, Noegel, Angelika A., Nolte, Elsie Magdalena, Norberg, Erik, Norga, Koenraad K., Noureini, Sakineh Kazemi, Notomi, Shoji, Notterpek, Lucia, Nowikovsky, Karin, Nukina, Nobuyuki, Nürnberger, Thorsten, O'donnell, Valerie B., O'donovan, Tracey, O'dwyer, Peter J., Oehme, Ina, Oeste, Clara L., Ogawa, Michinaga, Ogretmen, Besim, Ogura, Yuji, Oh, Young J., Ohmuraya, Masaki, Ohshima, Takayuki, Ojha, Rani, Okamoto, Koji, Okazaki, Toshiro, Oliver, F. Javier, Ollinger, Karin, Olsson, Stefan, Orban, Daniel P., Ordonez, Paulina, Orhon, Idil, Orosz, Laszlo, O'rourke, Eyleen J., Orozco, Helena, Ortega, Angel L., Ortona, Elena, Osellame, Laura D., Oshima, Junko, Oshima, Shigeru, Osiewacz, Heinz D., Otomo, Takanobu, Otsu, Kinya, Ou, Jing-Hsiung Jame, Outeiro, Tiago F., Ouyang, Dong-Yun, Ouyang, Hongjiao, Overholtzer, Michael, Ozbun, Michelle A., Ozdinler, P. Hande, Ozpolat, Bulent, Pacelli, Consiglia, Paganetti, Paolo, Page, Guyléne, Pages, Gille, Pagnini, Ugo, Pajak, Beata, Pak, Stephen C., Pakos-Zebrucka, Karolina, Pakpour, Nazzy, Palková, Zdena, Palladino, Francesca, Pallauf, Kathrin, Pallet, Nicola, Palmieri, Marta, Paludan, Søren R., Palumbo, Camilla, Palumbo, Silvia, Pampliega, Olatz, Pan, Hongming, Pan, Wei, Panaretakis, Theochari, Pandey, Aseem, Pantazopoulou, Areti, Papackova, Zuzana, Papademetrio, Daniela L., Papassideri, Issidora, Papini, Alessio, Parajuli, Nirmala, Pardo, Julian, Parekh, Vrajesh V., Parenti, Giancarlo, Park, Jong-In, Park, Junsoo, Park, Ohkmae K., Parker, Roy, Parlato, Rosanna, Parys, Jan B., Parzych, Katherine R., Pasquet, Jean-Max, Pasquier, Benoit, Pasumarthi, Kishore B.S., Patschan, Daniel, Pattingre, Sophie, Pattison, Scott, Pause, Arnim, Pavenstädt, Hermann, Pavone, Flaminia, Pedrozo, Zully, Peña, Fernando J., Peñalva, Miguel A., Pende, Mario, Peng, Jianxin, Penna, Fabio, Penninger, Josef M., Pensalfini, Anna, Pepe, Salvatore, Pereira, Gustavo J.S., Pereira, Paulo C., de la Cruz, Verónica Pérez, Pérez-Pérez, María Esther, Pérez-Rodríguez, Diego, Pérez-Sala, Dolore, Perier, Celine, Perl, Andra, Perlmutter, David H., Perrotta, Ida, Pervaiz, Shazib, Pesonen, Maija, Pessin, Jeffrey E., Peters, Godefridus J., Petersen, Morten, Petrache, Irina, Petrof, Basil J., Petrovski, Goran, Phang, James M., Piacentini, Mauro, Pierdominici, Marina, Pierre, Philippe, Pierrefite-Carle, Valérie, Pietrocola, Federico, Pimentel-Muiños, Felipe X., Pinar, Mario, Pineda, Benjamin, Pinkas-Kramarski, Ronit, Pinti, Marcello, Pinton, Paolo, Piperdi, Bilal, Piret, James M., Platanias, Leonidas C., Platta, Harald W., Plowey, Edward D., Pöggeler, Stefanie, Poirot, Marc, Polčic, Peter, Poletti, Angelo, Poon, Audrey H., Popelka, Hana, Popova, Blagovesta, Poprawa, Izabela, Poulose, Shibu M., Poulton, Joanna, Powers, Scott K., Powers, Ted, Pozuelo-Rubio, Mercede, Prak, Krisna, Prange, Reinhild, Prescott, Mark, Priault, Muriel, Prince, Sharon, Proia, Richard L., Proikas-Cezanne, Tassula, Prokisch, Holger, Promponas, Vasilis J., Przyklenk, Karin, Puertollano, Rosa, Pugazhenthi, Subbiah, Puglielli, Luigi, Pujol, Aurora, Puyal, Julien, Pyeon, Dohun, Qi, Xin, Qian, Wen-Bin, Qin, Zheng-Hong, Qiu, Yu, Qu, Ziwei, Quadrilatero, Joe, Quinn, Frederick, Raben, Nina, Rabinowich, Hannah, Radogna, Flavia, Ragusa, Michael J., Rahmani, Mohamed, Raina, Komal, Ramanadham, Sasanka, Ramesh, Rajagopal, Rami, Abdelhaq, Randall-Demllo, Sarron, Randow, Felix, Rao, Hai, Rao, V. Ashutosh, Rasmussen, Blake B., Rasse, Tobias M., Ratovitski, Edward A., Rautou, Pierre-Emmanuel, Ray, Swapan K., Razani, Babak, Reed, Bruce H., Reggiori, Fulvio, Rehm, Marku, Reichert, Andreas S., Rein, Theo, Reiner, David J., Reits, Eric, Ren, Jun, Ren, Xingcong, Renna, Maurizio, Reusch, Jane E.B., Revuelta, Jose L., Reyes, Leticia, Rezaie, Alireza R., Richards, Robert I., Richardson, Des R., Richetta, Clémence, Riehle, Michael A., Rihn, Bertrand H., Rikihisa, Yasuko, Riley, Brigit E., Rimbach, Gerald, Rippo, Maria Rita, Ritis, Konstantino, Rizzi, Federica, Rizzo, Elizete, Roach, Peter J., Robbins, Jeffrey, Roberge, Michel, Roca, Gabriela, Roccheri, Maria Carmela, Rocha, Sonia, Rodrigues, Cecilia M.P., Rodríguez, Clara I., de Cordoba, Santiago Rodriguez, Rodriguez-Muela, Natalia, Roelofs, Jeroen, Rogov, Vladimir V., Rohn, Troy T., Rohrer, Bärbel, Romanelli, Davide, Romani, Luigina, Romano, Patricia Silvia, Roncero, M. Isabel G., Rosa, Jose Lui, Rosello, Alicia, Rosen, Kirill V., Rosenstiel, Philip, Rost-Roszkowska, Magdalena, Roth, Kevin A., Roué, Gael, Rouis, Mustapha, Rouschop, Kasper M., Ruan, Daniel T., Ruano, Diego, Rubinsztein, David C., Rucker, Edmund B., Rudich, Assaf, Rudolf, Emil, Rudolf, Ruediger, Ruegg, Markus A., Ruiz-Roldan, Carmen, Ruparelia, Avnika Ashok, Rusmini, Paola, Russ, David W., Russo, Gian Luigi, Russo, Giuseppe, Russo, Rossella, Rusten, Tor Erik, Ryabovol, Victoria, Ryan, Kevin M., Ryter, Stefan W., Sabatini, David M., Sacher, Michael, Sachse, Carsten, Sack, Michael N., Sadoshima, Junichi, Saftig, Paul, Sagi-Eisenberg, Ronit, Sahni, Sumit, Saikumar, Pothana, Saito, Tsunenori, Saitoh, Tatsuya, Sakakura, Koichi, Sakoh-Nakatogawa, Machiko, Sakuraba, Yasuhito, Salazar-Roa, María, Salomoni, Paolo, Saluja, Ashok K., Salvaterra, Paul M., Salvioli, Rosa, Samali, Afshin, Sanchez, Anthony M.J., Sánchez-Alcázar, José A., Sanchez-Prieto, Ricardo, Sandri, Marco, Sanjuan, Miguel A., Santaguida, Stefano, Santambrogio, Laura, Santoni, Giorgio, Dos Santos, Claudia Nune, Saran, Shweta, Sardiello, Marco, Sargent, Graeme, Sarkar, Pallabi, Sarkar, Sovan, Sarrias, Maria Rosa, Sarwal, Minnie M., Sasakawa, Chihiro, Sasaki, Motoko, Sass, Miklo, Sato, Ken, Sato, Miyuki, Satriano, Joseph, Savaraj, Niramol, Saveljeva, Svetlana, Schaefer, Liliana, Schaible, Ulrich E., Scharl, Michael, Schatzl, Hermann M., Schekman, Randy, Scheper, Wiep, Schiavi, Alfonso, Schipper, Hyman M., Schmeisser, Hana, Schmidt, Jen, Schmitz, Ingo, Schneider, Bianca E., Schneider, E. Marion, Schneider, Jaime L., Schon, Eric A., Schönenberger, Miriam J., Schönthal, Axel H., Schorderet, Daniel F., Schröder, Bernd, Schuck, Sebastian, Schulze, Ryan J., Schwarten, Melanie, Schwarz, Thomas L., Sciarretta, Sebastiano, Scotto, Kathleen, Scovassi, A. Ivana, Screaton, Robert A., Screen, Mark, Seca, Hugo, Sedej, Simon, Segatori, Laura, Segev, Nava, Seglen, Per O., Seguí-Simarro, Jose M., Segura-Aguilar, Juan, Seiliez, Iban, Seki, Ekihiro, Sell, Christian, Semenkovich, Clay F., Semenza, Gregg L., Sen, Utpal, Serra, Andreas L., Serrano-Puebla, Ana, Sesaki, Hiromi, Setoguchi, Takao, Settembre, Carmine, Shacka, John J., Shajahan-Haq, Ayesha N., Shapiro, Irving M., Sharma, Shweta, She, Hua, Shen, C.-K. Jame, Shen, Chiung-Chyi, Shen, Han-Ming, Shen, Sanbing, Shen, Weili, Sheng, Rui, Sheng, Xianyong, Sheng, Zu-Hang, Shepherd, Trevor G., Shi, Junyan, Shi, Qiang, Shi, Qinghua, Shi, Yuguang, Shibutani, Shusaku, Shibuya, Kenichi, Shidoji, Yoshihiro, Shieh, Jeng-Jer, Shih, Chwen-Ming, Shimada, Yohta, Shimizu, Shigeomi, Shin, Dong Wook, Shinohara, Mari L., Shintani, Michiko, Shintani, Takahiro, Shioi, Tetsuo, Shirabe, Ken, Shiri-Sverdlov, Ronit, Shirihai, Orian, Shore, Gordon C., Shu, Chih-Wen, Shukla, Deepak, Sibirny, Andriy A., Sica, Valentina, Sigurdson, Christina J., Sigurdsson, Einar M., Sijwali, Puran Singh, Sikorska, Beata, Silveira, Wilian A., Silvente-Poirot, Sandrine, Silverman, Gary A., Simak, Jan, Simmet, Thoma, Simon, Anna Katharina, Simon, Hans-Uwe, Simone, Cristiano, Simons, Matia, Simonsen, Anne, Singh, Rajat, Singh, Shivendra V., Singh, Shrawan K., Sinha, Debasish, Sinha, Sangita, Sinicrope, Frank A., Sirko, Agnieszka, Sirohi, Kapil, Sishi, Balindiwe J.N., Sittler, Annie, Siu, Parco M., Sivridis, Efthimio, Skwarska, Anna, Slack, Ruth, Slaninová, Iva, Slavov, Nikolai, Smaili, Soraya S., Smalley, Keiran S.M., Smith, Duncan R., Soenen, Stefaan J., Soleimanpour, Scott A., Solhaug, Anita, Somasundaram, Kumaravel, Son, Jin H., Sonawane, Avinash, Song, Chunjuan, Song, Fuyong, Song, Hyun Kyu, Song, Ju-Xian, Song, Wei, Soo, Kai Y., Sood, Anil K., Soong, Tuck Wah, Soontornniyomkij, Virawudh, Sorice, Maurizio, Sotgia, Federica, Soto-Pantoja, David R., Sotthibundhu, Areechun, Sousa, Maria João, Spaink, Herman P., Span, Paul N., Spang, Anne, Sparks, Janet D., Speck, Peter G., Spector, Stephen A., Spies, Claudia D., Springer, Wolfdieter, Clair, Daret St, Stacchiotti, Alessandra, Staels, Bart, Stang, Michael T., Starczynowski, Daniel T., Starokadomskyy, Petro, Steegborn, Clemen, Steele, John W., Stefanis, Leonida, Steffan, Joan, Stellrecht, Christine M., Stenmark, Harald, Stepkowski, Tomasz M., Stern, Stęphan T., Stevens, Craig, Stockwell, Brent R., Stoka, Veronika, Storchova, Zuzana, Stork, Björn, Stratoulias, Vassili, Stravopodis, Dimitrios J., Strnad, Pavel, Strohecker, Anne Marie, Ström, Anna-Lena, Stromhaug, Per, Stulik, Jiri, Su, Yu-Xiong, Su, Zhaoliang, Subauste, Carlos S., Subramaniam, Srinivasa, Sue, Carolyn M., Suh, Sang Won, Sui, Xinbing, Sukseree, Supawadee, Sulzer, David, Sun, Fang-Lin, Sun, Jiaren, Sun, Jun, Sun, Shi-Yong, Sun, Yang, Sun, Yi, Sun, Yingjie, Sundaramoorthy, Vinod, Sung, Joseph, Suzuki, Hidekazu, Suzuki, Kuninori, Suzuki, Naoki, Suzuki, Tadashi, Suzuki, Yuichiro J., Swanson, Michele S., Swanton, Charle, Swärd, Karl, Swarup, Ghanshyam, Sweeney, Sean T., Sylvester, Paul W., Szatmari, Zsuzsanna, Szegezdi, Eva, Szlosarek, Peter W., Taegtmeyer, Heinrich, Tafani, Marco, Taillebourg, Emmanuel, Tait, Stephen W.G., Takacs-Vellai, Krisztina, Takahashi, Yoshinori, Takáts, Szabolc, Takemura, Genzou, Takigawa, Nagio, Talbot, Nicholas J., Tamagno, Elena, Tamburini, Jerome, Tan, Cai-Ping, Tan, Lan, Tan, Mei Lan, Tan, Ming, Tan, Yee-Joo, Tanaka, Keiji, Tanaka, Masaki, Tang, Daolin, Tang, Dingzhong, Tang, Guomei, Tanida, Isei, Tanji, Kunikazu, Tannous, Bakhos A., Tapia, Jose A., Tasset-Cuevas, Inmaculada, Tatar, Marc, Tavassoly, Iman, Tavernarakis, Nektario, Taylor, Allen, Taylor, Graham S., Taylor, Gregory A., Taylor, J. Paul, Taylor, Mark J., Tchetina, Elena V., Tee, Andrew R., Teixeira-Clerc, Fatima, Telang, Sucheta, Tencomnao, Tewin, Teng, Ba-Bie, Teng, Ru-Jeng, Terro, Faraj, Tettamanti, Gianluca, Theiss, Arianne L., Theron, Anne E., Thomas, Kelly Jean, Thomé, Marcos P., Thomes, Paul G., Thorburn, Andrew, Thorner, Jeremy, Thum, Thoma, Thumm, Michael, Thurston, Teresa L.M., Tian, Ling, Till, Andrea, Ting, Jenny Pan-Yun, Ting, Jenny Pan Yun, Titorenko, Vladimir I., Toker, Lilach, Toldo, Stefano, Tooze, Sharon A., Topisirovic, Ivan, Torgersen, Maria Lyngaa, Torosantucci, Liliana, Torriglia, Alicia, Torrisi, Maria Rosaria, Tournier, Cathy, Towns, Roberto, Trajkovic, Vladimir, Travassos, Leonardo H., Triola, Gemma, Tripathi, Durga Nand, Trisciuoglio, Daniela, Troncoso, Rodrigo, Trougakos, Ioannis P., Truttmann, Anita C., Tsai, Kuen-Jer, Tschan, Mario P., Tseng, Yi-Hsin, Tsukuba, Takayuki, Tsung, Allan, Tsvetkov, Andrey S., Tu, Shuiping, Tuan, Hsing-Yu, Tucci, Marco, Tumbarello, David A., Turk, Bori, Turk, Vito, Turner, Robin F.B., Tveita, Anders A., Tyagi, Suresh C., Ubukata, Makoto, Uchiyama, Yasuo, Udelnow, Andrej, Ueno, Takashi, Umekawa, Midori, Umemiya-Shirafuji, Rika, Underwood, Benjamin R., Ungermann, Christian, Ureshino, Rodrigo P., Ushioda, Ryo, Uversky, Vladimir N., Uzcátegui, Néstor L., Vaccari, Thoma, Vaccaro, Maria I., Váchová, Libuše, Vakifahmetoglu-Norberg, Helin, Valdor, Rut, Valente, Enza Maria, Vallette, Francoi, Valverde, Angela M., Van den Berghe, Greet, Van Den Bosch, Ludo, van den Brink, Gijs R., van der Goot, F. Gisou, van der Klei, Ida J., van der Laan, Luc J.W., van Doorn, Wouter G., van Egmond, Marjolein, van Golen, Kenneth L., Van Kaer, Luc, Campagne, Menno van Lookeren, Vandenabeele, Peter, Vandenberghe, Wim, Vanhorebeek, Ilse, Varela-Nieto, Isabel, Vasconcelos, M. Helena, Vasko, Radovan, Vavvas, Demetrios G., Vega-Naredo, Ignacio, Velasco, Guillermo, Velentzas, Athanassios D., Velentzas, Panagiotis D., Vellai, Tibor, Vellenga, Edo, Vendelbo, Mikkel Holm, Venkatachalam, Kartik, Ventura, Natascia, Ventura, Salvador, Veras, Patrícia S.T., Verdier, Mireille, Vertessy, Beata G., Viale, Andrea, Vidal, Michel, Vieira, Helena L.A., Vierstra, Richard D., Vigneswaran, Nadarajah, Vij, Neeraj, Vila, Miquel, Villar, Margarita, Villar, Victor H., Villarroya, Joan, Vindis, Cécile, Viola, Giampietro, Viscomi, Maria Teresa, Vitale, Giovanni, Vogl, Dan T., Voitsekhovskaja, Olga V., von Haefen, Clarissa, von Schwarzenberg, Karin, Voth, Daniel E., Vouret-Craviari, Valérie, Vuori, Kristina, Vyas, Jatin M., Waeber, Christian, Walker, Cheryl Lyn, Walker, Mark J., Walter, Jochen, Wan, Lei, Wan, Xiangbo, Wang, Bo, Wang, Caihong, Wang, Chao-Yung, Wang, Chengshu, Wang, Chenran, Wang, Chuangui, Wang, Dong, Wang, Fen, Wang, Fuxin, Wang, Guanghui, Wang, Hai-Jie, Wang, Haichao, Wang, Hong-Gang, Wang, Hongmin, Wang, Horng-Dar, Wang, Jing, Wang, Junjun, Wang, Mei, Wang, Mei-Qing, Wang, Pei-Yu, Wang, Peng, Wang, Richard C., Wang, Shuo, Wang, Ting-Fang, Wang, Xian, Wang, Xiao-Jia, Wang, Xiao-Wei, Wang, Xin, Wang, Xuejun, Wang, Yan, Wang, Yanming, Wang, Ying, Wang, Ying-Jan, Wang, Yipeng, Wang, Yu, Wang, Yu Tian, Wang, Yuqing, Wang, Zhi-Nong, Wappner, Pablo, Ward, Carl, Ward, Diane McVey, Warnes, Gary, Watada, Hirotaka, Watanabe, Yoshihisa, Watase, Kei, Weaver, Timothy E., Weekes, Colin D., Wei, Jiwu, Weide, Thoma, Weihl, Conrad C., Weindl, Günther, Weis, Simone Nardin, Wen, Longping, Wen, Xin, Wen, Yunfei, Westermann, Benedikt, Weyand, Cornelia M., White, Anthony R., White, Eileen, Whitton, J. Lindsay, Whitworth, Alexander J., Wiels, Joëlle, Wild, Franziska, Wildenberg, Manon E., Wileman, Tom, Wilkinson, Deepti Sriniva, Wilkinson, Simon, Willbold, Dieter, Williams, Chri, Williams, Katherine, Williamson, Peter R., Winklhofer, Konstanze F., Witkin, Steven S., Wohlgemuth, Stephanie E., Wollert, Thoma, Wolvetang, Ernst J., Wong, Esther, Wong, G. William, Wong, Richard W., Wong, Vincent Kam Wai, Woodcock, Elizabeth A., Wright, Karen L., Wu, Chunlai, Wu, Defeng, Wu, Gen Sheng, Wu, Jian, Wu, Junfang, Wu, Mian, Wu, Min, Wu, Shengzhou, Wu, William K.K., Wu, Yaohua, Wu, Zhenlong, Xavier, Cristina P.R., Xavier, Ramnik J., Xia, Gui-Xian, Xia, Tian, Xia, Weiliang, Xia, Yong, Xiao, Hengyi, Xiao, Jian, Xiao, Shi, Xiao, Wuhan, Xie, Chuan-Ming, Xie, Zhiping, Xie, Zhonglin, Xilouri, Maria, Xiong, Yuyan, Xu, Chuanshan, Xu, Congfeng, Xu, Feng, Xu, Haoxing, Xu, Hongwei, Xu, Jian, Xu, Jianzhen, Xu, Jinxian, Xu, Liang, Xu, Xiaolei, Xu, Yangqing, Xu, Ye, Xu, Zhi-Xiang, Xu, Ziheng, Xue, Yu, Yamada, Takahiro, Yamamoto, Ai, Yamanaka, Koji, Yamashina, Shunhei, Yamashiro, Shigeko, Yan, Bing, Yan, Bo, Yan, Xianghua, Yan, Zhen, Yanagi, Yasuo, Yang, Dun-Sheng, Yang, Jin-Ming, Yang, Liu, Yang, Minghua, Yang, Pei-Ming, Yang, Peixin, Yang, Qian, Yang, Wannian, Yang, Wei Yuan, Yang, Xuesong, Yang, Yi, Yang, Ying, Yang, Zhifen, Yang, Zhihong, Yao, Meng-Chao, Yao, Pamela J., Yao, Xiaofeng, Yao, Zhenyu, Yao, Zhiyuan, Yasui, Linda S., Ye, Mingxiang, Yedvobnick, Barry, Yeganeh, Behzad, Yeh, Elizabeth S., Yeyati, Patricia L., Yi, Fan, Yi, Long, Yin, Xiao-Ming, Yip, Calvin K., Yoo, Yeong-Min, Yoo, Young Hyun, Yoon, Seung-Yong, Yoshida, Ken-Ichi, Yoshimori, Tamotsu, Young, Ken H., Yu, Huixin, Yu, Jane J., Yu, Jin-Tai, Yu, Jun, Yu, Li, Yu, W. Haung, Yu, Xiao-Fang, Yu, Zhengping, Yuan, Junying, Yuan, Zhi-Min, Yue, Beatrice Y.J.T., Yue, Jianbo, Yue, Zhenyu, Zacks, David N., Zacksenhaus, Eldad, Zaffaroni, Nadia, Zaglia, Tania, Zakeri, Zahra, Zecchini, Vincent, Zeng, Jinsheng, Zeng, Min, Zeng, Qi, Zervos, Antonis S., Zhang, Donna D., Zhang, Fan, Zhang, Guo, Zhang, Guo-Chang, Zhang, Hao, Zhang, Hong, Zhang, Hongbing, Zhang, Jian, Zhang, Jiangwei, Zhang, Jianhua, Zhang, Jing-Pu, Zhang, Li, Zhang, Lin, Zhang, Long, Zhang, Ming-Yong, Zhang, Xiangnan, Zhang, Xu Dong, Zhang, Yan, Zhang, Yang, Zhang, Yanjin, Zhang, Yingmei, Zhang, Yunjiao, Zhao, Mei, Zhao, Wei-Li, Zhao, Xiaonan, Zhao, Yan G., Zhao, Ying, Zhao, Yongchao, Zhao, Yu-Xia, Zhao, Zhendong, Zhao, Zhizhuang J., Zheng, Dexian, Zheng, Xi-Long, Zheng, Xiaoxiang, Zhivotovsky, Bori, Zhong, Qing, Zhou, Guang-Zhou, Zhou, Guofei, Zhou, Huiping, Zhou, Shu-Feng, Zhou, Xu-Jie, Zhu, Hongxin, Zhu, Hua, Zhu, Wei-Guo, Zhu, Wenhua, Zhu, Xiao-Feng, Zhu, Yuhua, Zhuang, Shi-Mei, Zhuang, Xiaohong, Ziparo, Elio, Zois, Christos E., Zoladek, Teresa, Zong, Wei-Xing, Zorzano, Antonio, and Zughaier, Susu M.
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Molecular Biology ,Cell Biology ,Settore BIO/06 - Anatomia Comparata E Citologia - Abstract
non presente
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- 2016
329. Comfort and patient-centred care without excessive sedation: the eCASH concept
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Vincent J, Shehabi Y, Walsh T, Pandharipande P, Ball J, Spronk P, Longrois D, Strom T, Conti G, Funk G, Badenes R, Mantz J, Spies C, and Takala J
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- 2016
330. Plasma pharmacokinetics of daptomycin in critically ill patients with renal failure and undergoing CVVHD
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Harm Peters, Spies C, Uhrig A, Puhlmann B, Eggers K, Ina Lieker, Christian Joukhadar, H.-H. Neumayer, Dymtro Khadzhynov, Traunmüller F, Torsten Slowinski, and König T
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Male ,medicine.medical_specialty ,Critical Illness ,medicine.medical_treatment ,Cmax ,Urology ,Loading dose ,Normal renal function ,Daptomycin ,Pharmacokinetics ,Renal Dialysis ,polycyclic compounds ,medicine ,Humans ,Pharmacology (medical) ,In patient ,Prospective Studies ,Renal Insufficiency ,Intensive care medicine ,Aged ,Aged, 80 and over ,Pharmacology ,business.industry ,Critically ill ,Middle Aged ,Anti-Bacterial Agents ,Hemodialysis ,business ,medicine.drug - Abstract
Background Daptomycin is a novel antibiotic with primarily renal elimination. Methods In an open-label, prospective trial, the pharmacokinetics of daptomycin after single (8 mg/kg BW) and multiple intravenous doses (4 mg/kg BW) at steady state were determined in critically ill, dialysis-dependent patients treated with continuous veno-venous hemodialysis (CVVHD). Daptomycin levels were determined by HPLC. Subjects with normal renal function received one dose of 4 mg/kg BW of daptomycin. Results In the normal controls, daptomycin administration resulted in a mean maximum concentration (Cmax) of 60.7 ± 10.7 mg/l and an area under the time-versus-concentration curve from 0 to 24 h (AUC0-24) of 402 ± 56 mg × h/l. In the CVVHD-treated patients, a loading dose of 8 mg/kg lead to Cmax of 87.5 ± 15.0 mg/l, AUC0-24 of 537 ± 97 mg × h/l and AUC24-48 of 193 ± 69 mg × h/l, respectively. After multiple doses of 4 mg/kg every 48 h, Cmax was 41.8 ± 5.0 mg/l, AUC0-24 302 ± 43 mg × h/l and AUC 24-48 h 102 ± 24 mg × h/l, respectively. Approximately 40% of the daptomycin dose administered was removed by CVVHD. Mean plasma half-lives of daptomycin in patients were 2 - 3 times longer than in healthy controls. Conclusions The dosing regimen of 4 mg/kg TBW of daptomycin administered to CVVHD patients every 48 h is inappropriate to achieve effective antimicrobial plasma concentrations of daptomycin in the second half of the dosing interval (24 - 48 h). Doses of ≥ 4 mg/kg TBW administered intravenously every 24 h are necessary in CVVHD patients to assure that plasma daptomycin levels are comparably high to subjects with normal renal function and to avoid underdosing.
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- 2011
331. Poster Discussions
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Berger, M. M., Reymond, M. J., Shenkin, A., Wardle, C. A., Rey, F., Pannatier, A., Cavadini, C., Gaillard, R. C., Chloléro, R., Spies, C. D., Rommelspacher, H., Ehlert, A., Schaffartzik, W., Badawy, A. A. -B., Carroll, P. V., Jackson, N. C., Umpleby, M., Sönksen, P. H., Russell-Jones, D. L., Treacher, D. F., Brinkmann, A., Wolf, C. -F., Kneitinger, E., Radermacher, P., Seeling, W., Georgieff, M., Ensinger, H., Rantala, A., Vogt, J., and Takala, J.
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- 1996
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332. Free Papers
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Sheng, Luo Ping, Liu, Zi Wen, Liang, Bao Hen, Zhong, Jia Hong, Oldörp, B., Schilling, A. M., Lippmann, J., Öhring, R., Heidenreich, J., Kiem, E., Hennig, K., Michel, C., Neumann, T., Brodel, C., Heidt, P., Schaffartzik, W., Spies, C., Lannoo, E., De Deyne, C., Colardyn, F., Adam, S., Ragaller, M., Hampl, J., May, S. A., Schackert, G., Albrecht, D. M., Nava, J. M., Alyarez, M., Quintana, S., Pérez, J. Martinez, Jara, F., Cherta, I., Garcia-Bach, M., de Leon, J. L. Maestro, Vila, F., Vivenza, C., Cristofori, L., Gambin, R., Bricolo, A., Salvi, G., Rigoli, G., and Avesani, R.
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- 1996
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333. Präoperative Nahrungskarenz: Ein update
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Spies, C. D., Breuer, J. P., Gust, R., Wichmann, M., Adolph, M., Senkal, M., Kampa, U., Weissauer, W., Schleppers, A., Soreide, E., Martin, E., Kaisers, U., Falke, K. J., Haas, N., and Kox, W. J.
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- 2004
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334. Die Messung der Griffkraft
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Hahn, P., primary, Spies, C., additional, Unglaub, F., additional, and Mühldorfer-Fodor, M., additional
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- 2017
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335. Electroencephalogram dynamics in children during different levels of anaesthetic depth
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Koch, S., primary, Stegherr, A.M., additional, Mörgeli, R., additional, Kramer, S., additional, Toubekis, E., additional, Lichtner, G., additional, von Dincklage, F., additional, and Spies, C., additional
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- 2017
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336. Kubitaltunnelsyndrom
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Spies, C. K., primary, Löw, S., additional, Langer, M. F, additional, Hohendorff, B., additional, Müller, L. P., additional, and Unglaub, F., additional
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- 2017
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337. Postoperative Behandlung von Fingergelenkprothesen
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Hohendorff, B., primary, Vollmers, S., additional, Behrendt, M., additional, Unglaub, F., additional, Spies, C. K., additional, Müller, L. P., additional, and Ries, C., additional
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- 2017
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338. Erratum zu: Die Behandlung des Fibromyalgiesyndroms mit Gamma-Hydroxybuttersäure
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Reuter, E., primary, Tafelski, S., additional, Thieme, K., additional, West, C., additional, Haase, U., additional, Beck, L., additional, Schäfer, M., additional, and Spies, C., additional
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- 2017
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339. Die Fingerendgelenkversteifung mit der Doppelgewindeschraube
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Spies, C. K., primary, Hohendorff, B., additional, Löw, S., additional, Müller, L. P., additional, Oppermann, J., additional, Hahn, P., additional, and Unglaub, F., additional
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- 2017
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340. Sonographische Normwerte des Ringbandsystems Erwachsener
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Spies, C., primary, Bassemir, D., additional, Hahn, P., additional, Bruckner, T., additional, and Unglaub, F., additional
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- 2017
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341. OP0187 Transgenic disruption of glucocorticoid-signaling in mature osteoblasts and osteocytes attenuates structural bone damage in a long-term murine k/bxn serum-induced arthritis model
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Wiebe, E, primary, Spies, C, additional, Tu, J, additional, Maleitzke, T, additional, Zhang, Y, additional, Seibel, M, additional, Zhou, H, additional, and Buttgereit, F, additional
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- 2017
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342. (Teil‑)Arthrodesen am Handgelenk
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Unglaub, F., primary, Langer, M. F., additional, Unglaub, J. M., additional, Sauerbier, M., additional, Müller, L. P., additional, Krimmer, H., additional, Hahn, P., additional, and Spies, C. K., additional
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- 2017
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343. Das Trichorhinophalangeal-Syndrom Typ I – selten, aber eindrücklich
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Unglaub, F., additional, Hahn, P., additional, and Spies, C., additional
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- 2017
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344. Die Kompression des Nervus medianus durch ein luxiertes Mondbein aufgrund eines karpalen Kollapses
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Spies, C. K., primary, Schäfer, M., additional, Ahrens, C., additional, Hahn, P., additional, and Unglaub, F., additional
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- 2017
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345. Perkutane Nadelaponeurotomie bei Dupuytren-Kontraktur
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Oppermann, J., primary, Unglaub, F., additional, Müller, L. P., additional, Löw, S., additional, Hahn, P., additional, and Spies, C. K., additional
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- 2017
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346. Operative Behandlung der Dupuytren-Beugekontraktur
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Hohendorff, B., primary, Franke, J., additional, Spies, C. K., additional, Unglaub, F., additional, Müller, L. P., additional, and Ries, C., additional
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- 2017
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347. Diagnosing central lesions of the triangular fibrocartilage as traumatic or degenerative: a review of clinical accuracy
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Löw, S., primary, Erne, H., additional, Pillukat, T., additional, Mühldorfer-Fodor, M., additional, Unglaub, F., additional, and Spies, C. K., additional
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- 2017
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348. Delir, Analgesie und Sedierung in der Intensivmedizin
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Wolf, A., primary, Mörgeli, R., additional, Müller, A., additional, Weiss, B., additional, and Spies, C., additional
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- 2017
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349. Die bronteksouteur se bydrae tot die produksieproses van literêre vertalings
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Spies, C-M
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Literêre vertaling, bronteksouteur, produksieproses, sosiologiese enadering tot vertaling, Bourdieu, redigering, revisie - Abstract
In hierdie artikel word ʼn empiriese studie onderneem waarin die bydrae van die bronteksouteur in die produksieproses van literêre vertaling bestudeer word. Om hierdie doel te bereik, word drie produksieprosesse van literêre vertalings, To hell with Cronjé (Winterbach 2007b), My name is Vaselinetjie (Von Meck 2009a) en In bushveld and desert: A game ranger’s life (Bakkes 2008) retrospektiewelik bestudeer deur elke proses te herkonstrueer om die veranderinge wat die bronteksouteurs aangebring het, asook hulle korrespondensie met ander produksieagente, bloot te lê. Hiervoor word manuskripte, notas en e-poskorrespondensie wat tydens elke produksieproses geproduseer is, kwalitatief ontleed. Antwoorde op semi-gestruktureerde vraelyste word ook as sekondêre data bestudeer om die produksieagente die geleentheid te bied om oor die produksieproses te reflekteer en aan die navorser dinamika en aangeleenthede wat nie uit die primêre data afgelei kon word nie, te verduidelik. Die ontleding word gedoen teen die agtergrond van relevante sosiologiese, vertaal- en redigeer/revisieteorie, en bevindinge van vorige studies wat in die agtergrondbespreking aangebied word. Uit die analise kan daar gesien word dat alhoewel al die produksieagente ʼn beduidende rol in die produksie van ʼn literêre vertaling speel, wil dit wel voorkom of die bronteksouteur die produksieagent is wat die meeste status/outoriteit in die produksieproses geniet en gevolglik ook die meeste mag het en invloed kan uitoefen. Verder kan daar gesien word dat die betrokkenheid van die bronteksouteur in al drie prosesse voordelig was om inhoudelike foute en verkeerde interpretasies uit te skakel en ander produksieagente se vrae te beantwoord. Daar word egter ook aangedui dat die betrokkenheid van die bronteksouteur in sekere opsigte nadelig vir die produksieproses kan wees, byvoorbeeld wanneer hy/sy die teks tot só ʼn mate oorvertaal dat hy/sy as’t ware die rol van die vertaler oorneem en/of nder produksieagente ondermyn, wat wedywering en ʼn magswanbalans tot gevolg kan hê en die produksieproses kan strem.Sleutelwoorde: Literêre vertaling, bronteksouteur, produksieproses, sosiologiese enadering tot vertaling, Bourdieu, redigering, revisie
- Published
- 2015
350. Novel glucocorticoids : Where are we now and where do we want to go?
- Author
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Buttgereit, Frank, Spies, C. M., and Bijlsma, J. W J
- Subjects
Medicine(all) ,risk ratio [benefit] ,liposomal glucocorticoids ,Rheumatology ,Immunology ,selective glucocorticoid receptoragonists ,Immunology and Allergy ,glucocorticoid therapy ,benefit:risk ratio ,modified-release prednisone - Abstract
Glucocorticoid (GC) therapy is widely accepted as effective treatment for many inflammatory conditions. However, the potential of GC to produce adverse effects may prompt both patients and prescribing doctors to take a critical view on these important drugs. The increasing awareness of potential side effects suggests that the improvement of the benefit:risk ratio represents both a current need and an ongoing challenge. The developing and detailed knowledge on mechanisms of GC action has resulted in exploration of numerous approaches to optimise treatments with these important drugs. Most advanced is a chronotherapeutic formulation of prednisone (termed modified- or delayed- release prednisone) that has been recently approved in many European and other countries, and very recently also in the United States. Another interesting example is the development of selective GC receptor (GR) agonists, with clinical studies being currently underway. The development of so called liposomal GC is ongoing. However, another approach, the synergistic combination of prednisolone and dipyridamole, has been recently discontinued because a phase 2b study with the treatment in patients with rheumatoid arthritis showed a statistically significant improvement in disease activity score measured in 28 joints (DAS28) compared with placebo, but not compared with prednisolone alone. Other interesting developments and promising concepts include the development of nitrosteroids, targeting the membrane-bound GR and the use of extracts of the medicinal plant Tripterygium wilfordii Hook F.
- Published
- 2015
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