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Background: Regression of atheroma with reduction of cholesterol levels is recognized to occur, but less is known about reversal of sclerosis. Non-invasive indices of sclerosis have largely been based on carotid ultrasound measurements., Objective: To measure aortic compliance, coronary calcification and carotid intimal-medial thickness during reduction of cholesterol level in patients with and without coronary artery disease., Methods: We studied 64 hypercholesterolaemic patients, 24 with and 40 without coronary artery disease. All were administered fluvastatin for 1 year. Aortic compliance was assessed using magnetic resonance and coronary calcification score was determined by electron beam computed tomography. Carotid intimal-medial thickness in 34 patients was measured by carotid ultrasound means., Results: There was a rise in high-density lipoprotein cholesterol level and falls in total cholesterol level, low-density lipoprotein cholesterol level, low: high-density lipoprotein ratio, triglyceride level and very-low-density lipoprotein cholesterol level. Coronary artery disease patients had a higher coronary calcification score (442 +/- 551) than did other patients (269 +/- 724, P = 0.0002). For both groups there was a small rise in coronary calcification score during the study. Mean aortic compliance rose and blood pressure and carotid intimal-medial thickness fell. Analysis revealed significant correlations between change in mean aortic compliance and changes in high-density lipoprotein level (r = 0.3, P = 0.036), very-low-density lipoprotein level (r = -0.31, P = 0.038) and low: high-density lipoprotein ratio (r = -0.35, P = 0.014). There was no significant difference in these changes between the two patient groups., Conclusion: An improvement in aortic compliance over 1 year indicates that increase in high-density lipoprotein level, decrease in very-low-density lipoprotein level and improvement in low: high-density lipoprotein ratio caused by administration of fluvastatin beneficially influenced vascular pathophysiology in hypercholesterolaemic patients with and without coronary artery disease. In those patients studied with carotid ultrasound means, carotid intimal-medial thickness decreased from 1.09 to 0.87 mm (P = 0.004), corroborating these results.

Purpose: Retroperitoneal collections related to the psoas, in the absence of pancreatitis, are uncommon. This study reviews the imaging, pathogenesis and management of retroperitoneal collections with particular emphasis on distinguishing imaging features and the role of percutaneous drainage., Materials and Methods: Twenty-three retroperitoneal collections in 22 patients were reviewed in a 2-year period. Twenty-one patients underwent computed tomography (CT), with ultrasound (US) conducted in 14 and magnetic resonance imaging (MRI) in four. The clinical history and associated aetiological factors were noted. Methods of drainage were compared, pathological/microbiological results were recorded and the clinical outcome noted., Results: The mean age of presentation was 46.9 years (range 18-85 years). There was a male to female preponderance (17 to 6). Eighteen collections proved to be abscesses with five haematomas confirmed. Of the abscesses, three were primary and 15 were secondary to spinal, gastrointestinal or renal disease. Escherichia coli was the commonest isolated organism followed by Mycobacterium tuberculosis. No haematomas were drained. Twelve abscesses were drained successfully by percutaneous methods; three were managed with antibiotics alone; three were managed surgically., Conclusion: Secondary abscesses predominate and investigation should be directed at excluding a gastrointestinal or renal source. Tuberculous disease remains a significant problem. Percutaneous drainage allows effective management, even in the presence of a secondary abscess.

Intimal-medial thickness (IMT) of the inner arterial wall is a marker for early changes of atherosclerosis. In order to assess the IMT of the common carotid artery (CCA), two observers (A and B) examined the far wall of both CCAs of three groups of 10 healthy volunteers on two occasions, separated by a period of 2 weeks. Each observer examined one group, then both examined a third group (A, B and interobserver groups). The distance between the two echogenic lines representing the IMT of the arterial wall of the distal CCA was measured within 1 cm proximal to the carotid bulb. The maximal IMT at this site in the right and left CCAs was measured three times on each side and a mean value calculated. The mean of the absolute value of differences between both assessments was 0.027 mm for observer A, 0.027 mm for observer B and 0.0480 mm between observers. The calculated coefficient of variation was 5.02% for observer A, 5.70% for observer B and 8.98% between observers. The coefficient of repeatability was, 0.074 mm for observer A, 0.070 mm for observer B and 0.128 mm between observers. This method for estimating the IMT provides a reproducible and reliable measurement suitable for routine practice.

Spontaneous dissection of the internal carotid artery (ICA) is an unusual finding. We present an analysis of five patients (aged 40-60 years) with ICA dissections, describing the various flow patterns detected on colour Doppler ultrasound. Particular attention was paid to the presence of a dual lumen, the direction of flow in the false lumen and the velocity/spectral broadening of the Doppler trace obtained from the true and false lumens. Four different patterns were observed. Narrowing of the true lumen by the false lumen thrombus was seen in two cases with a low velocity Doppler waveform; three cases had a patent false lumen ("double lumen" pattern); the direction of flow in the patent false lumen varied from being (i) forward, (ii) reversed and (iii) bidirectional. The flow dynamics in carotid dissections are complex and are primarily dependent upon the presence of thrombus within the false lumen, the entry and exit flaps if the false lumen is patent, the motion of the flap wall and the extent of the dissection. They illustrate the diverse nature of the disease and Doppler ultrasound plays an important role in the imaging of ICA dissections.

An unusual case of pituitary apoplexy in a patient with pituitary abscess is described. The patient was found to have underlying chronic lymphocytic leukaemia and an associated hypogammaglobinaemia is postulated as being the predisposing cause for infection.

Background: Increased frequency of coronary heart disease in familial hypercholesterolaemia is well documented but the association with carotid atherosclerosis is less well established. The ultrasound appearances of the carotid arteries in familial hypercholesterolaemia patients without symptomatic cerebrovascular disease were therefore investigated., Methods: 59 patients (34 men, 25 women; mean age 46.6 (+/-12.1 years) were prospectively studied using ultrasound examination of the extracranial carotid vessels. Intimal-medial thickness was measured 1 cm proximal to the carotid bulb and morphology of plaque was classified as heterogeneous or homogeneous according to echogenicity., Results: 44 (75.0%) of the patients had carotid artery disease. On stepwise logistic regression, significant predictors of the presence of carotid artery disease were age (P = 0.014), serum triglycerides at time of examination (P = 0.013), coexistent coronary heart disease (P = 0.03) and the cholesterol-years score (CYS) (P = 0.015). Heterogeneous carotid plaque was associated with a higher plasma level of Lp(a) (P = 0.035), TG (P = 0.024), CYS (P = 0.0003) and the presence of CHD (P = 0.001). Matched pairs (n = 22) of patients, where the only variable was Lp(a), showed a marked increase in heterogeneous plaque frequency in those with high Lp(a) levels (P < 0.03)., Conclusion: Asymptomatic carotid artery disease occurs in a high proportion of familial hypercholesterolaemia patients. The presence of heterogeneous carotid plaque is significantly associated with the presence of coronary heart disease, the calculated cholesterol-years score, hypertriglyceridaemia and raised levels of Lp(a).

The subclavian steal syndrome results from occlusion of the proximal subclavian or innominate artery which causes reversal of blood flow in the ipsilateral vertebral artery. We describe a case where a further occlusion of the ipsilateral common carotid artery (CCA) resulted in an intermittent reversal of flow in the ipsilateral external carotid artery (ECA), to siphon blood up the internal carotid artery (ICA) and down the ipsilateral vertebral artery.

An asymptomatic 35-year-old female was found to have a congenital aneurysm of an anomalous splenic artery arising from the superior mesenteric artery on routine investigation for infertility. Demonstration on CT and angiography is presented and the pathogenesis, natural history, management, and implications during pregnancy are discussed.

Objectives: To combine surgical and radiological penile vein occlusion therapy in the treatment of patients with venogenic impotence, to try to improve on the results of either treatment used separately., Patients and Methods: Fourteen patients, with a mean age of 46 years (range 25-71), with pure venous-sinusoidal impotence were treated by surgical ligation of accessible veins and embolization of surgically inaccessible veins. The preliminary results over a follow-up period of at least 8 months are reported for each patient., Results: Venous embolization was considered complete in 11 patients. Overall, 13 had improved erectile function. Post-operatively, eight patients developed spontaneous erections and four (aged < 40 years) have maintained this for 8-24 months., Conclusion: Combined surgery and radiology treats the end result of the failure of the sinusoidal smooth muscle to relax. Although some patients, the majority of whom are young (aged < 40 years), will achieve short-term benefit, all individuals need to be fully counselled with regard to the likelihood of long-term benefit before undergoing this invasive method of treatment.

Isolated abscess of the pituitary gland is rare. The computed tomography (CT) appearances of a pituitary abscess have not been well documented. We describe an unusual case of a pituitary abscess and discuss the CT scan appearances.

A fully implantable drug delivery system has been shown to overcome many of the problems of long-term venous access. Traditionally these have required surgical implantation but we describe a simple, cost-effective and successful technique for the percutaneous insertion of an implantable vascular device (Vascuport, Ohmeda) in the angiography suite under local anaesthesia. It was successful in all 19 patients in whom it was attempted, with only one minor complication. We recommend that the procedure should be performed in X-ray departments using screening and conventional guidewire techniques.

A review of malaria cases over a five year period from 1984-1988 at the University Hospital, Kuala Lumpur, Malaysia is presented. A total of 64 cases were recorded; 50% of which were due to Plasmodium falciparum, 40.6% were due to Plasmodium vivax, 6.2% due to Plasmodium malariae and 3.1% due to a mixed infection of Plasmodium falciparum and Plasmodium vivax. The breakdown of species type compared similarly with other studies conducted in the region. Of this total, sixteen cases were imported from Pakistan, India, Thailand, Indonesia, Sri Lanka, Vietnam, Madagascar and Mali. The presenting symptoms and the clinical findings were typical of a malaria infection. The main problem in the future will be the increase in imported cases of malaria.

The case records of 64 patients with malaria over a five year period admitted to the University Hospital, Kuala Lumpur were examined. There were 32 cases of P. falciparum, 26 cases of P. vivax and two cases of mixed infections. Four cases of P. malariae were recorded. The clinical findings, biochemical and haematological parameters were examined for any indication of a pernicious syndrome. A high index of suspicion of a malarial infection may be based on the findings of anaemia, thrombocytopaenia, hyponatraemia, renal failure and abnormal liver function tests in the face of a negative blood film. These pernicious syndromes occur more often in malignant tertian malaria (anaemia 50%, hyponatraemia 39.1%) but a high percentage of the other malarial species show these abnormalities (P. vivax anaemia 57.7%, hyponatraemia 19.2%). When these abnormalities are present but blood films for malaria parasites are negative, repeat blood films are warranted until a parasitological diagnosis is achieved and correct treatment may be started.

A 32-year-old female ingested an unknown quantity of Nylax tablets containing phenolphthalein. This results in widespread organ involvement, predominantly causing liver damage and disseminated intravascular coagulation. The eventual cause of death was massive liver necrosis. We suggest that phenolphthalein was responsible for the widespread damage.

A 73 year old female presented with progressive hypoproteinaemic oedema which was resistant to treatment. The cause was not established until post-mortem, when it was found that she had angiotropic large cell lymphoma involving the vessels of the large intestine with mucosal ulceration. To our knowledge, this is the first report of angiotropic large cell lymphoma, which usually presents with neurological and skin involvement, presenting with protein-losing enteropathy.