292 results on '"Sato, Eriko"'
Search Results
252. 18F-Fluorodeoxyglucose positron emission tomography/computed tomography revealed the presence of simultaneous colon cancer in mucosa-associated lymphoid tissue lymphoma.
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Ichikawa, Kunimoto, Sugimoto, Koichi, Sato, Eriko, Sunami, Yoshitaka, Watanabe, Naoki, Ushimi, Takashi, and Komatsu, Norio
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LYMPHOMA diagnosis ,COLON tumors ,BIOPSY ,CANCER cells ,CYSTS (Pathology) ,DEOXY sugars ,IMMUNOBLOTTING ,IN situ hybridization ,NUCLEOTIDE separation ,RADIOPHARMACEUTICALS ,POSITRON emission tomography ,TUMOR classification ,COMORBIDITY ,DIAGNOSIS - Abstract
A letter to the editor is presented regarding the case of a 76-year-old woman who was diagnosed with simultaneous colon cancer in mucosa-associated lymphoid tissue lymphoma.
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- 2011
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253. Severe thrombocytopenia caused by littoral cell angioma.
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Suto, Hiroko, Imai, Hidenori, Sato, Eriko, Ando, Jun, Nobukawa, Bunsei, and Sugimoto, Koichi
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- 2008
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254. Multiple brain infarctions induced by imatinib mesylate in a patient with clonal eosinophilia.
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Sato, Eriko, Sugimoto, Koichi, Hamano, Yasuharu, Isobe, Yasushi, Sasaki, Makoto, Tomomatsu, Junichi, Nitta, Hideaki, and Oshimi, Kazuo
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- 2008
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255. The Routledge Course in Japanese Translation.
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Sato, Eriko and Hartill, Andrea
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JAPANESE language -- Translating ,NONFICTION - Published
- 2015
256. Laryngeal complications after endotracheal intubation and prone positioning in patients with coronavirus disease 2019.
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Aibara, Shiori, Okada, Masahiro, Tanaka‐Nishikubo, Kaori, Asayama, Rie, Sato, Eriko, Sei, Hirofumi, Aoishi, Kunihide, Takagi, Taro, Teraoka, Masato, Mukai, Naoki, Konishi, Saki, Okita, Mitsuo, Ogawa, Siro, Annen, Suguru, Ohshita, Muneaki, Matsumoto, Hironori, Murata, Satoru, Harima, Yutaka, Kikuchi, Satoshi, and Takeba, Jun
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COVID-19 , *PATIENT positioning , *TRACHEA intubation , *VOCAL cords , *BODY mass index , *MEDICAL records - Abstract
Objectives: Laryngeal complications have been reported after endotracheal intubation and prone positioning in patients with critical coronavirus disease 2019 (COVID‐19), but their association is unclear. In this study, we investigated the rate of laryngeal complications in patients with COVID‐19 compared to an alternative condition (control group). Methods: We retrospectively analyzed the data of 40 patients who underwent endotracheal intubation for either COVID‐19 or an alternative condition (control group). Data on age, sex, body mass index (BMI), cardiovascular disease (CVD) risk factors, use of prone therapy, duration of endotracheal intubation, and duration from extubation/tracheostomy to laryngeal evaluation were collected from medical records. Results: There were no significant differences in BMI, frequency of CVD risk factors, duration of endotracheal intubation, or duration from extubation/tracheostomy to laryngeal evaluation between the two groups. In the COVID‐19 group, all patients adopted the prone position. In comparison, only one patient in the control group adopted the prone position. Significant differences were observed between the two groups regarding the incidence of vocal fold immobility and laryngeal granuloma. Conclusion: Laryngeal complications were more common in the COVID‐19 group than in the control group. Prone positioning may be a risk factor for these complications. Level of Evidence: 4. [ABSTRACT FROM AUTHOR]
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- 2022
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257. Yeast-mediated synthesis of optically active diols with C 2-symmetry and ( R)-4-pentanolide
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Ikeda, Hajime, Sato, Eriko, Sugai, Takeshi, and Ohta, Hiromichi
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- 1996
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258. Synthesis of degradable network polymers containing peroxy units in the main chain or the cross-linking point
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Mihashi, Asako, Tamura, Hiroshi, Sato, Eriko, and Matsumoto, Akikazu
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CROSSLINKING (Polymerization) , *ISOCYANATES , *POLYMER colloids , *PEROXIDES , *CHEMICAL bonds , *CHEMICAL reactions , *POLYVINYL alcohol , *RADICALS (Chemistry) - Abstract
Abstract: We have synthesized degradable network polymers containing readily labile peroxy bonds as the repeating units in the main chain or as the cross-linking point in the side chain. Poly(2-hydroxyethyl sorbate-alt-O2) was obtained by the radical copolymerization of 2-hydroxyethyl sorbate with oxygen, and then cross-linked using tolylene 2,4-diisocyanate as the cross-linking agent to obtain a new type of degradable gel. We also investigated the cross-linking of conventional polymers by the reaction of the diene moieties introduced into the polymer side chain with oxygen. The hydroxy group in the side chain of poly(vinyl alcohol) (PVA) was reacted with 1-isocyanate-1,3-pentadiene in order to introduce a diene moiety into the side chain of the PVA. The dienylated PVA was reacted with oxygen in the presence of a radical initiator, leading to the formation of a gel containing a labile peroxy linkage at the cross-linking point. These gels containing peroxy units in the main chain or at the cross-linking points degraded upon heating. [Copyright &y& Elsevier]
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- 2010
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259. Utility of propenyl groups in free radical polymerization: Effects of steric hindrance on formation and reaction behavior as versatile intermediates
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Yamada, Bunichiro, Zetterlund, Per B., and Sato, Eriko
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POLYMERS , *POLYMERIZATION , *CARBON , *METHYL methacrylate , *ESTERS - Abstract
Abstract: 2-Substituted-2-propenyl groups can be introduced as polymer ω-end-groups by a variety of means in free radical polymerization. Addition-fragmentation chain transfer (AFCT) and catalytic chain transfer have been employed to introduce the 2-substituted-2-propenyl groups almost quantitatively under appropriate conditions when bimolecular termination cannot compete effectively with these processes as an end forming event. Unsaturated oligomers (dimers, trimers, tetramers and oligomers of higher degrees of polymerization) of methyl methacrylate and methyl acrylate function as carbon–carbon bond cleavage type AFCT agents and can be used to introduce the propenyl end-group. However, these compounds are not as reactive chain transfer agents as carbon-heteroatom bond cleavage type AFCT agents such as α-(bromomethyl)-, α-(alkylthiomethyl)- and α-(arenesulfonylmethyl)acrylates, which effectively reduce the molecular weight of the polymer formed and introduce the propenyl end-group. Mid-chain radicals formed during polymerization of acrylic esters are structurally similar to the radicals generated by radical addition to the 2-carbalkoxy-2-propenyl end-group. β-Fragmentation of the mid-chain radical can be regarded as the reverse reaction of radical addition to the propenyl end-group. Steric congestion accelerates formation of the propenyl end-group via β-fragmentation of the adduct radical, and suppresses intermolecular reactions of the adduct radicals to a larger extent than addition of the propagating radical to the propenyl end-group. Low molecular weight polymers bearing 2-carbalkoxy-2-propenyl and 2-phenyl-2-propenyl ω-end-groups undergo copolymerization as macromonomers with common vinyl monomers, with the exception of poly(methyl methacrylate)s bearing the propenyl end-groups, which primarily act as AFCT agents. Reactivities and reaction modes of α-(substituted methyl)acrylates and related monomers are also described in relation to the behavior of propenyl groups bound to polymer chains. [Copyright &y& Elsevier]
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- 2006
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260. Carboxypeptidase B inhibitors reduce tissue factor-induced renal microthrombi in rats
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Muto, Yuko, Suzuki, Kokichi, Sato, Eriko, and Ishii, Hidemi
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PEPTIDASE , *THROMBOSIS - Abstract
Procarboxypeptidase B (also known as thrombin-activatable fibrinolysis inhibitor) is a recently described plasma zymogen known to be activated by thrombin in plasma. Carboxy-terminal lysine residues from partially degraded fibrin are important for the binding and activation of plasminogen, and carboxypeptidase B, an active form of procarboxypeptidase B, has been shown to inhibit fibrinolysis by eliminating these residues. The present paper investigates the effects of carboxypeptidase B inhibitors, dl-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGPA) and potato-derived carboxypeptidase inhibitor (CPI), on tissue factor (TF)-induced microthrombosis in rats. Intravenous injection of MGPA (3 mg/kg and higher) or CPI (0.3 mg/kg and higher) after microthrombi formation dramatically attenuated TF-induced glomerular fibrin deposition with an increase in plasma levels of d-dimer. These results indicate that carboxypeptidase B inhibitors can enhance endogenous fibrinolysis and reduce thrombi in the TF-induced microthrombosis model after systemic administration even after thrombi formation. [Copyright &y& Elsevier]
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- 2003
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261. Features of vascular adverse events in Japanese patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a retrospective study of the CML Cooperative Study Group database.
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Fujioka, Isao, Takaku, Tomoiku, Iriyama, Noriyoshi, Tokuhira, Michihide, Kimura, Yuta, Sato, Eriko, Ishikawa, Maho, Nakazato, Tomonori, Sugimoto, Kei-Ji, Fujita, Hiroyuki, Asou, Norio, Kizaki, Masahiro, Hatta, Yoshihiro, Komatsu, Norio, and Kawaguchi, Tatsuya
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ASIANS , *COMPARATIVE studies , *CORONARY disease , *INFARCTION , *RESEARCH methodology , *MEDICAL cooperation , *PERIPHERAL vascular diseases , *RESEARCH , *EVALUATION research , *CHRONIC myeloid leukemia , *RETROSPECTIVE studies , *PROTEIN kinase inhibitors - Abstract
This study investigated the incidence rate and features of vascular adverse events (VAEs) in Japanese patients with chronic myeloid leukemia (CML) who were treated with tyrosine kinase inhibitors (TKIs). The analysis included 369 CML patients in the chronic or accelerated phases, selected from the CML Cooperative Study Group database; 25 events in 23 (6.2%) of these patients were VAEs. At the time of VAE incidence, nine patients were on treatment with imatinib, 12 with nilotinib, three with dasatinib, and one with bosutinib. VAE incidence comprised 13 cases of ischemic heart disease (IHD), eight of cerebral infarction (CI), and four of peripheral arterial occlusive disease (PAOD). IHD incidence rate in the study population was higher than that in the age-matched general population, particularly in nilotinib-treated patients, while CI incidence rate was almost equivalent. Compared with the Suita score, the SCORE chart and the Framingham score risk assessment tools detected more patients with high or very high risk of VAEs. In conclusion, incidence of IHD requires closer monitoring in nilotinib-treated patients. More detailed investigations for determining the most useful tool to predict VAE incidence and long-term analysis of therapy-related VAE cases are needed for improving safety during TKI therapy. [ABSTRACT FROM AUTHOR]
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- 2018
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262. Incidences and outcomes of therapy-related chronic myeloid leukemia in the era of tyrosine kinase inhibitors: Surveillance of the CML Cooperative Study Group.
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Iriyama, Noriyoshi, Tokuhira, Michihide, Takaku, Tomoiku, Sato, Eriko, Ishikawa, Maho, Nakazato, Tomonori, Sugimoto, Kei-Ji, Fujita, Hiroyuki, Fujioka, Isao, Hatta, Yoshihiro, Kizaki, Masahiro, Komatsu, Norio, Asou, Norio, and Kawaguchi, Tatsuya
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TREATMENT of chronic myeloid leukemia , *DISEASE incidence , *PROTEIN-tyrosine kinase inhibitors , *CANCER chemotherapy , *MEDICAL statistics - Abstract
This study was performed to investigate the features and outcome of patients with therapy-related chronic myeloid leukemia (TR-CML) who were treated with tyrosine kinase inhibitors (TKIs). The analysis included 308 patients with CML in the chronic phase who were extracted from the CML Cooperative Study Group database. Of these patients, 11 (3.6%) were identified as having TR-CML. No differences in age, sex, white blood cell count, hemoglobin level, platelet count, or European Treatment and Outcome Study risk were observed between patients with TR-CML vs. de novo CML. However, the responses of TR-CML patients to TKIs (6, 3, and 2 received imatinib, nilotinib, and dasatinib, respectively) were excellent; all achieved major or deep molecular response. Furthermore, the outcomes of TR-CML patients were relatively favorable; the 3-year event-free survival rates in the TR-CML and de novo CML patients were 100% and 94%, respectively; the difference was not statistically significant. In conclusion, our study showed that TR-CML patients could achieve a good clinical course with TKI therapy. Detailed investigations of TR-CML may provide new insights into CML biology. [ABSTRACT FROM AUTHOR]
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- 2017
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263. Problems of primary T-cell lymphoma of the thyroid gland -A case report.
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Yokoyama, Junkichi, Ito, Shin, Ohba, Shinichi, Fujimaki, Mitsuhisa, Sato, Eriko, Komatsu, Norio, Ikeda, Katsuhisa, and Hanaguri, Makoto
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T-cell lymphoma - Abstract
In the following report we discuss a very rare case of malignant T-cell lymphoma of the thyroid gland that developed in a 70-year-old woman with a past history of hypothyroidism due to chronic thyroiditis. The chief complaint was a rapidly growing neck mass. CT and ultrasonographic examination revealed a diffuse large thyroid gland without a nodule extending up to 13 cm. Although presence of abnormal lymphoid cells in the peripheral blood was not found, the sIL-2 Receptor antibody and thyroglobulin measured as high as 970 U/ml and 600 ng/mL respectively. Fine needle aspiration cytology diagnosed chronic thyroiditis. A preoperative diagnosis of suspicious malignant lymphoma of the thyroid gland accompanied by Hashimoto's thyroiditis was made, and a right hemithyroidectomy was performed to definite diagnosis. Histological examination revealed diffuse small lymphocytic infiltration in the thyroid gland associated with Hashimoto's thyroiditis. Immunohistochemical examination showed that the small lymphocytes were positive for T-cell markers with CD3 and CD45RO. The pathological diagnosis was chronic thyroiditis with atypical lymphocytes infiltration. However, Southern blot analysis of tumor specimens revealed only a monoclonal T-cell receptor gene rearrangement. Finally, peripheral T cell lymphoma was diagnosed. Therefore, the left hemithyroidectomy was also performed one month later. No adjuvant therapy was performed due to the tumor stage and its subtype. The patient is well with no recurrence or metastasis 22 months after the surgical removal of the thyroid. As malignant T-cell lymphoma of the thyroid gland with Hashimoto's thyroiditis was difficult to diagnose, gene rearrangement examination needed to be performed concurrently. [ABSTRACT FROM AUTHOR]
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- 2012
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264. Violin concerto, S. 1042 ; Concerto for two violins, S. 1043 ; Concerto for flute, violin, and harpsichord, S. 1044 ; Oboe d'amore concerto, S. 1055
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Bach, Johann Sebastian, 1685-1750, composer., Orchestra of St. Luke's, instrumentalist., Mann, Elizabeth, instrumentalist., Sato, Eriko, instrumentalist., Wolinsky, Robert, instrumentalist., Feeney, Krista Bennion, instrumentalist., Fukuhara, Mayuki, instrumentalist., Taylor, Stephen (Oboist), instrumentalist., Container of (work): Bach, Johann Sebastian, 1685-1750. Concertos, harpsichord, flute, violin, string orchestra, BWV 1044,, Container of (work): Bach, Johann Sebastian, 1685-1750. Concertos, violin, string orchestra, BWV 1042,, Container of (work): Bach, Johann Sebastian, 1685-1750. Concertos, violins (2), string orchestra, BWV 1043,, and Container of (expression): Bach, Johann Sebastian, 1685-1750. Concertos, harpsichord, string orchestra, BWV 1055, arranged.
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- 2008
265. Estrogen-related receptor expression in placenta throughout gestation
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Fujimoto, Jiro, Nakagawa, Yumiko, Toyoki, Hiroshi, Sakaguchi, Hideki, Sato, Eriko, and Tamaya, Teruhiko
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ESTROGEN receptors , *SEX hormones , *STEROID hormones , *MESSENGER RNA , *GENE expression - Abstract
Abstract: Estrogen receptor (ER) alpha and beta mRNA levels increased from the first to the second trimester and then decreased until normal term delivery. Estrogen-related receptor (ERR) alpha, beta and gamma mRNA levels gradually increased up to the second trimester and then comparatively rapidly increased until normal term delivery. ERRs can bind to the steroid receptor coactivator family without any ligands and drive transcription activity of the target genes. The manner of ERR and ER gene expressions might show a competitive interaction associated with the use of common cofactors. It is speculated that the up-regulation of ERRs is related to placental growth after the down-regulation of ERs because of the remarkably high concentration of estrogens for ERs from the second trimester until delivery. [Copyright &y& Elsevier]
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- 2005
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266. Changes in chronic myeloid leukemia treatment modalities and outcomes after introduction of second-generation tyrosine kinase inhibitors as first-line therapy: a multi-institutional retrospective study by the CML Cooperative Study Group.
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Iriyama N, Iwanaga E, Kimura Y, Watanabe N, Ishikawa M, Nakayama H, Sato E, Tabayashi T, Mitsumori T, Takaku T, Nakazato T, Tokuhira M, Fujita H, Ando M, Hatta Y, and Kawaguchi T
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- Humans, Retrospective Studies, Male, Middle Aged, Female, Aged, Adult, Treatment Outcome, Dasatinib therapeutic use, Aged, 80 and over, Pyrimidines therapeutic use, Adolescent, Young Adult, Prognosis, Tyrosine Kinase Inhibitors, Protein Kinase Inhibitors therapeutic use, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Leukemia, Myelogenous, Chronic, BCR-ABL Positive mortality, Imatinib Mesylate therapeutic use
- Abstract
This study investigated changes in treatment modalities and outcomes of chronic myeloid leukemia in the chronic phase (CP-CML) after the approval of second-generation tyrosine kinase inhibitors (2G-TKIs) for first-line therapy. Patients were grouped into those who underwent TKI therapy up to December 2010 (imatinib era group, n = 185) and after January 2011 (2G-TKI era group, n = 425). All patients in the imatinib era group were initially treated with imatinib, whereas patients in the 2G-TKI era group were mostly treated with dasatinib (55%) or nilotinib (36%). However, outcomes including progression-free survival, overall survival, and CML-related death (CRD) did not differ significantly between groups. When stratified by risk scores, the prognostic performance of the ELTS score was superior to that of the Sokal score. Even though both scoring systems predicted CRD in the imatinib era, only the ELTS score predicted CRD in the 2G-TKI era. Notably, the outcome of patients classified as high-risk by ELTS score was more favorable in the 2G-TKI era group than in the imatinib era group. Thus, expanding treatment options may have improved patient outcomes in CP-CML, particularly in patients classified as high-risk by ELTS score., (© 2024. Japanese Society of Hematology.)
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- 2024
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267. Management and Risk Factors for Pleural Effusion in Japanese Patients with Chronic Myeloid Leukemia Treated with First-line Dasatinib in Real-world Clinical Practice.
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Tsuchiya S, Takaku T, Watanabe N, Iriyama N, Kimura Y, Iwanaga E, Sugimoto KJ, Mitsumori T, Ishikawa M, Nakazato T, Fujita H, Sato E, Hatta Y, Asou N, Kizaki M, Tokuhira M, Ando M, and Kawaguchi T
- Subjects
- Aged, Humans, East Asian People, Protein Kinase Inhibitors therapeutic use, Retrospective Studies, Risk Factors, Dasatinib adverse effects, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Pleural Effusion chemically induced, Pleural Effusion epidemiology, Pleural Effusion drug therapy
- Abstract
Objective Pleural effusion (PE) is a common adverse event that occurs during dasatinib therapy for chronic myeloid leukemia (CML). However, the pathomechanism of PE and appropriate management of Asian patients with CML have not been elucidated. This study investigated the incidence rate, risk, and appropriate management of PE in Asian patients with CML treated with dasatinib. Methods We retrospectively collected data on patients in the chronic phase of CML who received first-line dasatinib therapy and were registered in the CML-Cooperative Study Group database. Patients We identified 44 cases of PE in a series of 89 patients and analyzed previously reported risk factors and effective management of PE. Results A univariate analysis revealed that age, diabetes mellitus, chronic renal failure, hypertension, the history of cardiovascular events, and dasatinib dose were significantly associated with PE. A multivariate analysis revealed that age ≥65 years old was the only independent risk factor for PE. Dasatinib dose reduction and switching to a tyrosine kinase inhibitor showed a statistically significant difference in effectively reducing PE volume compared to single diuretic use. Conclusion Although further studies are warranted, our observations showed that advanced age is a significant risk factor for PE, and tyrosine kinase inhibitor dose reduction or replacement of dasatinib may be an effective management strategy for PE in Asian CML patients who received first-line treatment with dasatinib in real-world clinical practice.
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- 2023
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268. Outcomes of 30 Gy/5 Fr Hypofractionated Stereotactic Radiation Therapy for Small Brain Metastases (≤2 cm).
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Kawai Y, Aramaki S, Ishihara T, Suzuki K, Okawa T, Sato E, Ota N, Kosugi T, Amano M, and Konishi K
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- Humans, Retrospective Studies, Treatment Outcome, Necrosis etiology, Radiosurgery adverse effects, Brain Neoplasms pathology, Radiation Injuries etiology
- Abstract
Background/aim: Stereotactic radiosurgery (SRS)-used for brain metastases (BMs) with a tumor diameter of ≤2 cm-has a high local control rate, however, it can cause symptomatic radiation-induced brain necrosis. Hypofractionated stereotactic radiation therapy (HFSRT) is not commonly used for such lesions and its effectiveness remains unknown. Herein, the efficacy of 30 Gy 5-fraction HFSRT for treating BMs of <2 cm was retrospectively evaluated., Patients and Methods: Patients who received HFSRT and had a gross tumor volume (GTV) of ≤2 cm in maximum diameter were included in the study (49 patients; 179 BMs; median follow-up period, 11.9 months)., Results: The mean GTV Peripheral Dose (D95) was 36.2 Gy. The local control (LC) rates at 1 and 2 years were 93.0% and 81.5%, respectively, for all lesions. The 1-year LC rates were 93.6% and 92.0% for ≤1.0-cm and 1.0-2.0-cm lesions, respectively. Multivariate analysis revealed that the only significant difference was in GTV maximal tumor diameter (HR=1.961, p=0.0002). Notably, only one patient had asymptomatic radiation necrosis., Conclusion: Owing to the high toxicity of SRS, 5-fraction HFSRT can be an effective treatment strategy for BMs of <2 cm., (Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
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- 2023
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269. Clinical management of second-generation tyrosine kinase inhibitor therapy in patients with newly diagnosed chronic myeloid leukemia in the chronic phase, focusing on age and dose effects.
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Tokuhira M, Kimura Y, Tabayashi T, Watanabe N, Tsuchiya S, Takaku T, Iriyama N, Sato E, Nakazato T, Mitsumori T, Ishikawa M, Fujita H, Kizaki M, Ando M, Hatta Y, Iwanaga E, and Kawaguchi T
- Subjects
- Humans, Aged, Dasatinib adverse effects, Protein Kinase Inhibitors adverse effects, Retrospective Studies, Pyrimidines, Treatment Outcome, Tyrosine Kinase Inhibitors, Leukemia, Myelogenous, Chronic, BCR-ABL Positive diagnosis, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
- Abstract
ABL1-tyrosine kinase inhibitors (TKIs) are an established treatment choice for patients with chronic myeloid leukemia in the chronic phase (CML-CP). However, effects of TKI dose modification have not been well investigated. In this study, we retrospectively analyzed 178 patients with newly diagnosed CML-CP who were treated with dasatinib or nilotinib, focusing on age and dose effects. Efficacy as measured by cumulative major molecular response (MMR) and molecular response 4.5 rates did not differ significantly between the younger group and elderly group. Elderly patients who started nilotinib at a reduced dose had similar or better efficacy outcomes (including cumulative MMR and continuation ratios) than other groups, and elderly patients who started dasatinib at a reduced dose had the lowest MMR ratio and longest MMR duration. Effects of dose modification based on age and TKI selection can be attributed to flexible management of TKI therapy in real-world practice, but further studies are required to validate the findings of this study., (© 2023. Japanese Society of Hematology.)
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- 2023
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270. Mutational analysis of DNMT3A improves the prognostic stratification of patients with acute myeloid leukemia.
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Wakita S, Marumo A, Morita K, Kako S, Toya T, Najima Y, Doki N, Kanda J, Kuroda J, Mori S, Satake A, Usuki K, Ueki T, Uoshima N, Kobayashi Y, Kawata E, Nakayama K, Nagao Y, Shono K, Shibusawa M, Tadokoro J, Hagihara M, Uchiyama H, Uchida N, Kubota Y, Kimura S, Nagoshi H, Ichinohe T, Kurosawa S, Motomura S, Hashimoto A, Muto H, Sato E, Ogata M, Mitsuhashi K, Ando J, Tashiro H, Sakaguchi M, Yui S, Arai K, Kitano T, Miyata M, Arai H, Kanda M, Itabashi K, Fukuda T, Kanda Y, and Yamaguchi H
- Subjects
- Humans, DNA Mutational Analysis, Mutation, Nucleophosmin genetics, Prognosis, Retrospective Studies, DNA (Cytosine-5-)-Methyltransferases genetics, Leukemia, Myeloid, Acute genetics
- Abstract
Nucleophosmin1 (NPM1) mutations are the most frequently detected gene mutations in acute myeloid leukemia (AML) and are considered a favorable prognostic factor. We retrospectively analyzed the prognosis of 605 Japanese patients with de novo AML, including 174 patients with NPM1-mutated AML. Although patients with NPM1-mutated AML showed a high remission rate, this was not a favorable prognostic factor for overall survival (OS); this is contrary to generally accepted guidelines. Comprehensive gene mutation analysis showed that mutations in codon R882 of DNA methyltransferase 3A (DNMT3A
R882 mutations) were a strong predicative factor indicating poor prognosis in all AML (p < 0.0001) and NPM1-mutated AML cases (p = 0.0020). Furthermore, multivariate analysis of all AML cases showed that DNMT3AR882 mutations and the co-occurrence of internal tandem duplication in FMS-like tyrosine kinase 3 (FLT3-ITD), NPM1 mutations, and DNMT3AR882 mutations (triple mutations) were independent factors predicting a poor prognosis related to OS, with NPM1 mutations being an independent factor for a favorable prognosis (hazard ratios: DNMT3AR882 mutations, 1.946; triple mutations, 1.992, NPM1 mutations, 0.548). Considering the effects of DNMT3AR882 mutations and triple mutations on prognosis and according to the classification of NPM1-mutated AML into three risk groups based on DNMT3AR882 /FLT3-ITD genotypes, we achieved the improved stratification of prognosis (p < 0.0001). We showed that DNMT3AR882 mutations are an independent factor for poor prognosis; moreover, when confounding factors that include DNMT3AR882 mutations were excluded, NPM1 mutations were a favorable prognostic factor. This revealed that ethnological prognostic discrepancies in NPM1 mutations might be corrected through prognostic stratification based on the DNMT3A status., (© 2023 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.)- Published
- 2023
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271. Cricotracheostomy for patients with severe COVID-19: A case control study.
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Mukai N, Okada M, Konishi S, Okita M, Ogawa S, Nishikawa K, Annen S, Ohshita M, Matsumoto H, Murata S, Harima Y, Kikuchi S, Aibara S, Sei H, Aoishi K, Asayama R, Sato E, Takagi T, Tanaka-Nishikubo K, Teraoka M, Hato N, Takeba J, and Sato N
- Abstract
Background: Tracheostomy is an important procedure for the treatment of severe coronavirus disease-2019 (COVID-19). Older age and obesity have been reported to be associated with the risk of severe COVID-19 and prolonged intubation, and anticoagulants are often administered in patients with severe COVID-19; these factors are also related to a higher risk of tracheostomy. Cricotracheostomy, a modified procedure for opening the airway through intentional partial cricoid cartilage resection, was recently reported to be useful in cases with low-lying larynx, obesity, stiff neck, and bleeding tendency. Here, we investigated the usefulness and safety of cricotracheostomy for severe COVID-19 patients., Materials and Methods: Fifteen patients with severe COVID-19 who underwent cricotracheostomy between January 2021 and April 2022 with a follow-up period of ≥ 14 days were included in this study. Forty patients with respiratory failure not related to COVID-19 who underwent traditional tracheostomy between January 2015 and April 2022 comprised the control group. Data were collected from medical records and comprised age, sex, body mass index, interval from intubation to tracheostomy, use of anticoagulants, complications of tracheostomy, and decannulation., Results: Age, sex, and days from intubation to tracheostomy were not significantly different between the COVID-19/cricotracheostomy and control/traditional tracheostomy groups. Body mass index was significantly higher in the COVID-19 group than that in the control group ( P = 0.02). The rate of use of anticoagulants was significantly higher in the COVID-19 group compared with the control group ( P < 0.01). Peri-operative bleeding, subcutaneous emphysema, and stomal infection rates were not different between the groups, while stomal granulation was significantly less in the COVID-19 group ( P = 0.04)., Conclusions: These results suggest that cricotracheostomy is a safe procedure in patients with severe COVID-19., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Mukai, Okada, Konishi, Okita, Ogawa, Nishikawa, Annen, Ohshita, Matsumoto, Murata, Harima, Kikucih, Aibara, Sei, Aoishi, Asayama, Sato, Takagi, Tanaka-Nishikubo, Teraoka, Hato, Takeba and Sato.)
- Published
- 2023
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272. Outcomes of adolescents and young adults with chronic-phase chronic myeloid leukaemia treated with tyrosine kinase inhibitors.
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Nishiyama-Fujita Y, Nakazato T, Iriyama N, Tokuhira M, Ishikawa M, Sato E, Takaku T, Sugimoto K, Fujita H, Fujioka I, Tsuchiya S, Kimura Y, Iwanaga E, Komatsu N, Asou N, Kizaki M, Hatta Y, and Kawaguchi T
- Subjects
- Adolescent, Humans, Imatinib Mesylate adverse effects, Imatinib Mesylate therapeutic use, Protein Kinase Inhibitors adverse effects, Protein Kinase Inhibitors therapeutic use, Retrospective Studies, Young Adult, Leukemia, Myelogenous, Chronic, BCR-ABL Positive diagnosis, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Leukemia, Myeloid, Chronic-Phase diagnosis, Leukemia, Myeloid, Chronic-Phase drug therapy
- Abstract
Introduction: Few studies have reported the outcomes of adolescents and young adults (AYAs) with chronic-phase chronic myeloid leukaemia (CML-CP) on tyrosine kinase inhibitors (TKIs)., Materials and Methods: We retrospectively analysed the clinical features, treatment response, and long-term outcomes of 42 AYA patients, in comparison to older patients. The initial therapies of AYA patients between 2001 and 2016 included imatinib ( n = 24), dasatinib ( n = 13) and nilotinib ( n = 5)., Results: In AYA patients, the peripheral blood (PB) white blood cell count and percentage of blasts at the diagnosis were significantly higher, haemoglobin levels were lower and the spleen size was larger. The major molecular response (MMR), event-free survival (EFS) and overall survival (OS) rates were comparable. A sub-analysis comparing imatinib to second-generation TKIs as the initial therapy also showed that their prognosis was comparable., Discussion: In conclusion, the tumour burden at the diagnosis of CML-CP is higher in AYA patients; however, their prognosis was not worse in comparison to older patients treated with TKIs. KEY MESSAGESFew studies have reported the outcomes of adolescents and young adults (AYAs) with chronic-phase chronic myeloid leukaemia (CML-CP) on tyrosine kinase inhibitors (TKIs). This study showed the tumour burden at the diagnosis of CML-CP is higher in AYA pa tients; however, their prognosis was not worse in comparison to older patients treated with TKIs. Understanding the biological and non-biological features of AYA patients with CML-CP on TKI therapy is essential for better management and to improve the outcomes.
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- 2022
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273. NPM1-mutation-based measurable residual disease assessment after completion of two courses of post-remission therapy is a valuable clinical predictor of the prognosis of acute myeloid leukemia.
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Marumo A, Wakita S, Morita K, Oh I, Kako S, Toya T, Najima Y, Doki N, Kanda J, Kuroda J, Mori S, Satake A, Usuki K, Uoshima N, Kobayashi Y, Kawata E, Nagao Y, Shono K, Shibusawa M, Tadokoro J, Hagihara M, Uchiyama H, Kubota Y, Kimura S, Motomura S, Hashimoto A, Muto H, Sato E, Ogata M, Mitsuhashi K, Ando J, Date K, Fujiwara Y, Terada K, Yui S, Arai K, Kitano T, Miyata M, Ohashi K, Kanda Y, and Yamaguchi H
- Subjects
- Humans, Mutation, Neoplasm, Residual diagnosis, Neoplasm, Residual genetics, Nucleophosmin, Prognosis, Recurrence, Hematopoietic Stem Cell Transplantation, Leukemia, Myeloid, Acute diagnosis, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute therapy
- Abstract
Recent studies have reported that measurable residual disease (MRD) analysis using NPM1 mutations helps determine whether allogeneic hematopoietic stem cell transplantation (allo-HSCT) is indicated in acute myeloid leukemia (AML) patients. However, the optimal timing and cutoff value for measuring MRD using genomic DNA remain undetermined. This study aimed to investigate the optimal timing and cutoff value to ascertain the value of NPM1 mutation in MRD assessment. NPM1-mutated MRD was quantified by real-time polymerase chain reaction of bone marrow samples from 56 patients with NPM1-positive AML who achieved hematological remission. The area under the receiver-operating characteristic curve was greatest when MRD was assessed after two courses of post-remission therapy with a cutoff value of 0.010% (specificity, 68.4%; sensitivity, 87.0%). Patients whose MRD was below the cutoff value throughout the course of treatment had significantly better overall survival and relapse-free survival rates. Of the 33 patients who did not undergo transplantation during the first remission, all of the 11 who were never MRD-negative at any point experienced a relapse. Evaluating MRD with a cutoff value of 0.010% after two courses of post-remission therapy helps predict prognosis and determine the indication for allo-HSCT., (© 2022. Japanese Society of Hematology.)
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- 2022
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274. Prognostic impact of CEBPA bZIP domain mutation in acute myeloid leukemia.
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Wakita S, Sakaguchi M, Oh I, Kako S, Toya T, Najima Y, Doki N, Kanda J, Kuroda J, Mori S, Satake A, Usuki K, Ueki T, Uoshima N, Kobayashi Y, Kawata E, Tajika K, Nagao Y, Shono K, Shibusawa M, Tadokoro J, Kayamori K, Hagihara M, Uchiyama H, Uchida N, Kubota Y, Kimura S, Nagoshi H, Ichinohe T, Kurosawa S, Motomura S, Hashimoto A, Muto H, Sato E, Ogata M, Mitsuhashi K, Ando J, Marumo A, Omori I, Fujiwara Y, Terada K, Yui S, Arai K, Kitano T, Miyata M, Kurosawa A, Mizoguchi A, Komatsu N, Fukuda T, Ohashi K, Kanda Y, Inokuchi K, and Yamaguchi H
- Subjects
- Aged, CCAAT-Enhancer-Binding Protein-alpha genetics, Humans, Karyotype, Mutation, Prognosis, CCAAT-Enhancer-Binding Proteins genetics, Leukemia, Myeloid, Acute diagnosis, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute metabolism
- Abstract
Mutations of CCAAT/enhancer-binding protein alpha (CEBPAmu) are found in 10% to 15% of de novo acute myeloid leukemia (AML) cases. Double-mutated CEBPA (CEBPAdm) is associated with a favorable prognosis; however, single-mutated CEBPA (CEBPAsm) does not seem to improve prognosis. We investigated CEBPAmu for prognosis in 1028 patients with AML, registered in the Multi-center Collaborative Program for Gene Sequencing of Japanese AML. It was found that CEBPAmu in the basic leucine zipper domain (bZIP) was strongly associated with a favorable prognosis, but CEBPAmu out of the bZIP domain was not. The presence of CEBPAmu in bZIP was a strong indicator of a higher chance of achieving complete remission (P < .001), better overall survival (OS; P < .001) and a lower risk of relapse (P < .001). The prognostic significance of CEBPAmu in bZIP was also observed in the subgroup with CEBPAsm (all patients: OS, P = .008; the cumulative incidence of relapse, P = .063; patients aged ≤70 years and with intermediate-risk karyotype: OS, P = .008; cumulative incidence of relapse, P = .026). Multivariate analysis of 744 patients aged ≤70 years showed that CEBPAmu in bZIP was the most potent predictor of OS (hazard ratio, 0.3287; P < .001). CEBPAdm was validated as a cofounding factor, which was overlapping with CEBPAmu in bZIP. In summary, these findings indicate that CEBPAmu in bZIP is a potent marker for AML prognosis. It holds potential in the refinement of treatment stratification and the development of targeted therapeutic approaches in CEBPA-mutated AML., (© 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.)
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- 2022
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275. Case-specific three-dimensional hologram with a mixed reality technique for tumor resection in otolaryngology.
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Mitani S, Sato E, Kawaguchi N, Sawada S, Sakamoto K, Kitani T, Sanada T, Yamada H, and Hato N
- Abstract
Objective: We report our first experience of using a case-specific three-dimensional (3D) hologram for tumor resection in otolaryngology to show the proof of concept. In addition, a questionnaire was administered to assess the usefulness of the mixed reality technique in otolaryngology., Methods: A case-specific 3D hologram was developed from enhanced images of dynamic computed tomography, with reference to contrast-enhanced magnetic resonance images, and used for preoperative planning and intraoperative image reference. To evaluate the usefulness of the 3D hologram with head mount displays (HMDs), 18 attendings and resident otolaryngologists completed a questionnaire with the Likert scale., Results: The case-specific 3D hologram on HMDs was successfully used by means of easy gesture-handling without any monitors preoperatively and intraoperatively. The experience of picturing the tumor localization and evaluating the surgical approach was statistically better using the 3D hologram on HMDs than using the computer images ( P < .01). Similarly, the holograms were observed to be better for intraoperative application and surgical education than computer images ( P < .01)., Conclusion: We demonstrated the use of a case-specific 3D hologram for tumor resection in otolaryngology. The technology may be useful for preoperative planning and intraoperative image reference, especially for challenging cases, and surgical education., Level of Evidence: NA., Competing Interests: All authors declare no conflict of interest., (© 2021 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.)
- Published
- 2021
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276. The EUTOS long-term survival score predicts disease-specific mortality and molecular responses among patients with chronic myeloid leukemia in a practice-based cohort.
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Sato E, Iriyama N, Tokuhira M, Takaku T, Ishikawa M, Nakazato T, Sugimoto KJ, Fujita H, Kimura Y, Fujioka I, Asou N, Komatsu N, Kizaki M, Hatta Y, and Kawaguchi T
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Agents therapeutic use, Biomarkers, Tumor antagonists & inhibitors, Disease Progression, Female, Fusion Proteins, bcr-abl antagonists & inhibitors, Humans, Imatinib Mesylate therapeutic use, Japan, Leukemia, Myelogenous, Chronic, BCR-ABL Positive diagnosis, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Leukemia, Myelogenous, Chronic, BCR-ABL Positive mortality, Male, Middle Aged, Predictive Value of Tests, Progression-Free Survival, Protein Kinase Inhibitors therapeutic use, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Young Adult, Biomarkers, Tumor genetics, Decision Support Techniques, Fusion Proteins, bcr-abl genetics, Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics
- Abstract
The European Treatment and Outcome Study (EUTOS) long-term survival (ELTS) score predicts disease-specific death in patients with chronic myeloid leukemia (CML) being treated with imatinib during the chronic phase (CP) of the disease. However, it is unclear whether the ELTS score predicts CML-related events or treatment responses. This study evaluated the predictive value of the ELTS score regarding prognosis and treatment response in patients with CML-CP. Clinical data were retrospectively obtained from patients enrolled in the CML Cooperative Study Group (CML-CSG), which included patients diagnosed with CML-CP from April 2001 to January 2016, and treated with any tyrosine kinase inhibitor (TKI) as first-line therapy. Among 342 eligible patients, the ELTS scores indicated low-, intermediate-, and high-risk in 74%, 21%, and 5% of patients, respectively. Patients with high ELTS scores had significantly higher disease-specific mortality and worse event-free survival, progression-free survival, and overall survival. Among four risk scores, including the Sokal, Hasford, EUTOS, and ELTS scores, risk stratification by the ELTS score had the highest predictive value in assessing patient prognosis, and also in treatment responses. In fact, the EUTOS and ELTS scores were able to predict the major molecular response within 12 months. Most importantly, the ELTS score was the only scoring system that predicted deep molecular response at any time, regardless of risk level (65.0%, 43.7%, and 23.5% in low-, intermediate-, and high-risk groups, respectively). Compared to other risk scores, the ELTS score was the most sensitive risk classification tool for the four endpoints of interest in this study, as well as molecular responses in patients with CML-CP., (© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
- Published
- 2020
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277. Development of proficiency-based knot-tying and suturing curriculum for otolaryngology residents: A pilot study.
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Sato E, Mitani S, Nishio N, Kitani T, Sanada T, Ugumori T, Christopher Holsinger F, Baik FM, and Hato N
- Subjects
- Humans, Pilot Projects, Competency-Based Education, Curriculum, Internship and Residency, Otolaryngology education, Suture Techniques education
- Abstract
Objective: Basic surgical skills such as knot-tying and suturing are important for all otolaryngologists, regardless of subspecialty. The present study was undertaken in order to assess basic surgical techniques such as knot-tying and suturing required for novice otolaryngology residents with taking the variety of subspecialties into consideration, and evaluate the impact of a proficiency-based training curriculum based on these techniques., Methods: A prospective study was performed for developing of proficiency-based knot-tying and suturing curriculum for otolaryngology residents in the third post-graduate year (PGY-3). The proficiency-based training curriculum was developed based on the tasks selected by RAND/UCLA method with expert panel, which is an iterative and anonymous survey used to establish consensus among participants. Expert panelists were selected from various divisions to reflect variety of their subspecialties. PGY-3 residents trained with the developed curriculum that included proctored pre-test, self-training to proficiency, and proctored post-test. Visual analogue scale (VAS) of trainees' overall competence in the operating room was self-assessed by each resident, before and after completing the training curriculum., Results: Nine PGY-3 residents were enrolled as trainees. Eleven experts chosen as panelists had various subspecialty, including 2 from otology, 2 from rhinology, 2 from laryngology, 2 from head and neck surgery, and 3 from general otolaryngology. Seven tasks were selected from RAND/UCLA method and used to develop the curriculum. Trainee scores at pre-test were significantly lower than expert scores for all 7 tasks (p < 0.01) and each coefficient of variation of trainee score was larger than that of expert score (p < 0.05), supporting construct validity. The mean of composite scores between pre-test and post-test had statistical significance (68.6 ± 11.6 vs 95.9 ± 3.6, p < 0.01), documenting substantial improvement after training. Self-assessment VAS was also improved pre- to post-training (1.2 ± 0.9 vs 4.5 ± 1.4, p < 0.01). A follow-up questionnaire showed that trainees felt the educational curriculum to be beneficial., Conclusion: In the present study, seven basic technical skills were selected using the RAND/UCLA method and used to create a proficiency-based training curriculum. Our results indicate that this curriculum significantly improves proficiency of basic surgical skills of junior otolaryngology residents., Competing Interests: Declaration of Competing Interest All authors declare no conflict of interest., (Copyright © 2019. Published by Elsevier B.V.)
- Published
- 2020
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278. Potential role for second‑generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia harboring additional clonal chromosome abnormalities: A retrospective CML Cooperative Study Group analysis.
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Ishikawa M, Iriyama N, Tokuhira M, Takaku T, Sato E, Sugimoto KJ, Nakazato T, Fujita H, Kimura Y, Fujioka I, Komatsu N, Asou N, Kizaki M, Hatta Y, and Kawaguchi T
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Chromosome Aberrations drug effects, Clonal Evolution genetics, Disease-Free Survival, Female, Humans, Imatinib Mesylate adverse effects, Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics, Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology, Male, Middle Aged, Philadelphia Chromosome drug effects, Protein Kinase Inhibitors adverse effects, Treatment Outcome, Young Adult, Clonal Evolution drug effects, Imatinib Mesylate administration & dosage, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Protein Kinase Inhibitors administration & dosage
- Abstract
Tyrosine kinase inhibitor (TKI) treatment is the standard of care for patients with chronic myeloid leukemia (CML). Even in the imatinib era, the presence of 'clonal chromosomal abnormalities' in the Philadelphia chromosome (CCA/Ph+) at diagnosis reportedly increased the risk of disease progression and predicted shorter survival. However, it remains unclear whether CCA/Ph+ is a poor prognostic marker in the era of new‑generation TKIs. The data of patients with CML in the chronic phase (CP) that were extracted from the CML Cooperative Study Group database were retrospectively analyzed. Of the 328 eligible patients, 33 (10.1%) had CCA/Ph+, including 9 major route and 24 minor route aberrations. The characteristics of patients with and without CCA/Ph+ were similar; however, the proportion of blasts was higher among patients with CCA/Ph+. Notably, the survival rate of patients with CCA/Ph+ was not inferior to that of patients without CCA/Ph+, and there were no differences in responses to TKIs. All 9 patients with major route CCA/Ph+ attained a major molecular response (MMR) with no disease progression, and 8 ultimately achieved a deep molecular response. In particular, the median interval between TKI initiation and achievement of MMR was shorter in patients initially treated with a second‑generation TKI than in those treated with imatinib (5 vs. 10 months). The present retrospective study, thus, revealed favorable treatment outcomes in CML‑CP patients with CCA/Ph+ treated with second‑generation TKIs. The data indicated that administering second‑generation TKIs as first‑line treatments is preferable in CML‑CP patients with CCA/Ph+.
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- 2019
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279. Vitamin B6 deficiency is prevalent in primary and secondary myelofibrosis patients.
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Yasuda H, Tsutsui M, Ando J, Inano T, Noguchi M, Yahata Y, Tanaka M, Tsukune Y, Masuda A, Shirane S, Misawa K, Gotoh A, Sato E, Aritaka N, Sekiguchi Y, Sugimoto K, and Komatsu N
- Subjects
- Adult, Anemia, Copper blood, Female, Folic Acid blood, Humans, Male, Middle Aged, Prevalence, Primary Myelofibrosis etiology, Prospective Studies, Pyridoxal Phosphate therapeutic use, Vitamin B 6 Deficiency drug therapy, Primary Myelofibrosis blood, Vitamin B 6 Deficiency blood
- Abstract
Vitamin B6 (VB6) deficiency contributes to oncogenesis and tumor progression in certain cancers, and is prevalent in cancer patients in general. VB6 is also an essential element of heme synthesis, and deficiency can lead to anemia. Primary myelofibrosis (PMF) and secondary myelofibrosis (sMF) are myeloproliferative neoplasms often presenting with anemia along with other cytopenias. We performed a prospective study to determine whether PMF and sMF patients suffer from VB6 deficiency, and whether VB6-deficient patients show improvement of anemias with VB6 supplementation. Twelve PMF patients and 11 sMF patients were analyzed. A total of 16 of 23 patients (69.6%) were found to have VB6 deficiency, but VB6 supplementation with pyridoxal phosphate hydrate did not elevate hemoglobin levels in deficient patients. None of the patients presented with vitamin B12, iron, or copper deficiencies. Four patients showed serum folate levels below the lower limit of normal and eight patients showed serum zinc levels below the lower limit of normal; however, these deficiencies were marginal and unlikely to contribute to anemia. Compared to VB6-sufficient patients, VB6-deficient patients showed significantly lower serum folate levels and higher serum copper levels. Studies elucidating the relationship of VB6 deficiency and etiology of PMF/sMF are warranted.
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- 2019
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280. Retrospective Analysis of 20 Patients with DLBCL Who Received MCVAC Followed by Autologous Peripheral Blood Stem Cell Transplantation.
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Sekiguchi Y, Wakabayashi M, Takizawa H, Iizuka H, Sakajiri S, Sugimoto K, Inano T, Fukuda Y, Hamano Y, Hirano T, Sato E, Aritaka N, Yahata Y, Morita K, Okamura T, Tomita S, Izumi H, Okubo M, Nakamura N, Sawada T, and Noguchi M
- Subjects
- Antineoplastic Combined Chemotherapy Protocols, Cyclophosphamide, Etoposide, Humans, Retrospective Studies, Transplantation Conditioning, Transplantation, Autologous, Lymphoma, Large B-Cell, Diffuse therapy, Peripheral Blood Stem Cell Transplantation
- Abstract
Autologous peripheral blood stem cell transplantation(auto-PBSCT)combined with high-dose chemotherapy has been considered as the standard therapy for relapsed or induction therapy-refractory aggressive lymphomas sensitive to chemotherapy. While various regimens have been applied as the conditioning,none has yet been established as the standard. We have begun to employ high-dose ranimustine,cytarabine,etoposide and cyclophosphamide(MCVAC)regimen. The present study was undertaken to review the efficacy and safety of MCVAC. Regimen: We carried out a retrospective analysis of 20 patients diagnosed as diffuse large B-cell lymphoma. The median follow-up duration of 20 patients was 13.05 months(range, 0.57-49.5 months). The 4-year OS and PFS were 57.8% and 30.2%,respectively. Relapse was the most frequent cause of treatment failure(n=7). The major toxicities were anorexia/nausea(95%),diarrhea (75%),hypokalemia (70%). One patient died of hepatic veno-occlusive disease(VOD). The serious adverse events included hypokalemia,arrhythmia,cerebral hemorrhage,and heart failure(1 case[5%]each). There was 1 case of a late-onset adverse event: therapy-related myelo- dysplastic syndrome/acute myeloblastic leukemia(MDS/AML). MCVAC regimen was concluded as effective and well-toler- ated. However,we should carefully monitored for the possible development of VOD and MDS/AML. Further follow-up is needed to evaluate the long-term efficacy and safety.
- Published
- 2019
281. Smoking influences the outcomes of patients receiving tyrosine kinase inhibitors for chronic myeloid leukemia in the chronic phase: A retrospective analysis.
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Iriyama N, Tokuhira M, Sato E, Sugimoto KJ, Takaku T, Ishikawa M, Nakazato T, Fujita H, Kimura Y, Fujioka I, Asou N, Komatsu N, Kizaki M, Hatta Y, and Kawaguchi T
- Subjects
- Aged, Chronic Disease, Disease-Free Survival, Female, Humans, Male, Middle Aged, Retrospective Studies, Survival Rate, Databases, Factual, Imatinib Mesylate administration & dosage, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Leukemia, Myelogenous, Chronic, BCR-ABL Positive mortality, Smoking mortality
- Published
- 2019
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282. Study on Control of pH-Modulation Crystallization Utilizing Concept of Dissociation Equilibrium.
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Sato E, Kudo S, and Takiyama H
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- Hydrogen-Ion Concentration, Sodium Hydroxide chemistry, Solubility, Anti-Bacterial Agents chemistry, Azo Compounds chemistry, Cephalosporins chemistry, Crystallization methods
- Abstract
Crystallization by pH adjustment, as a type of reaction crystallization, is a solid-liquid separation method widely used in the area of pharmaceutical and pharmaceutical intermediate manufacturing. On the other hand, 3-alkenyl cephem compound is a typical zwitterionic pharmaceutical intermediate that possesses both an amino group and a carboxylic acid group. Such structure affords three main pH regions in solution and results in difficulties using crystallization by pH adjustment for isolation. As a consequence, 3-alkenyl cephem compound is usually crystallized at the point away from the solubility curve, causing unrestricted nucleation and flocculation behavior for the deposited particles which is difficult to filtrate. In this study, the pK
a of 3-alkenyl cephem compound was intensively investigated to inhibit the nucleation. An optimal pH level point was also sought to make monodisperse particles. In particular, during crystallization by pH-modulation operation, the key point was identified to be the number of primary particles aggregated in the secondary particles. It was revealed that the increment number of primary particles led to the generation of larger monodisperse particles. This investigation, combined with solid-liquid equilibrium, enabled the acquisition of target species with good operability for filtration process. This present investigation becomes the prosperity in the zwitterion compound production that it has hardships to crystallize and filtrate.- Published
- 2019
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283. Utility of immunohistochemistry with an antibody against MYC at the initial diagnosis of follicular lymphoma, grade 3A, for predicting a more aggressive clinical course: a case report and review of the literature.
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Ichikawa K, Aritaka N, Ogura K, Hosone M, Ota Y, Sato E, Komatsu N, and Hirano T
- Subjects
- Aged, 80 and over, Biomarkers, Tumor genetics, DNA-Binding Proteins genetics, Disease Progression, Fatal Outcome, Female, Genetic Predisposition to Disease, Humans, In Situ Hybridization, Fluorescence, Lymphoma, B-Cell genetics, Lymphoma, B-Cell pathology, Lymphoma, Follicular genetics, Lymphoma, Follicular pathology, Neoplasm Grading, Phenotype, Predictive Value of Tests, Proto-Oncogene Proteins c-bcl-2 genetics, Proto-Oncogene Proteins c-bcl-6, Proto-Oncogene Proteins c-myc genetics, Time Factors, Translocation, Genetic, Biomarkers, Tumor analysis, Immunohistochemistry, Lymphoma, B-Cell chemistry, Lymphoma, Follicular chemistry, Proto-Oncogene Proteins c-myc analysis
- Abstract
Follicular lymphoma (FL) is the most common indolent lymphoma, and associated with the chromosomal translocation t(14;18)(q32;q21). While, FL harboring both BCL2 and MYC translocation at diagnosis is very rare. The evaluation of MYC expression in typical FL at presentation using southern blot, G-banded karyotyping or fluorescence in situ hybridization (FISH) analyses has been described so far. However, there are no reports about the use of immunohistochemistry (IHC) to evaluate MYC protein expression in FL at presentation. Here, we present a FL patient who transformed to a B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt's lymphoma, accompanied by concurrent BCL2, BCL6, and MYC translocations; i.e., triple-hit lymphoma. Paraffin-embedded tissue section-FISH analysis demonstrated that the FL was negative for MYC, but MYC protein expression was subsequently detected in the lymph node specimen obtained at the initial diagnosis using IHC. This case revealed aggressive clinical course and central nervous system involvement. In the literature concerning MYC positive FL five out of 8 patients were dead within 24 months. The detection of MYC protein expression in FL using IHC might be useful to predict more aggressive clinical course.
- Published
- 2015
284. Consequences of the JAK2V617F allele burden for the prediction of transformation into myelofibrosis from polycythemia vera and essential thrombocythemia.
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Shirane S, Araki M, Morishita S, Edahiro Y, Sunami Y, Hironaka Y, Noguchi M, Koike M, Sato E, Ohsaka A, and Komatsu N
- Subjects
- Bone Marrow pathology, Disease Progression, Humans, Hydroxyurea therapeutic use, Polycythemia Vera pathology, Primary Myelofibrosis drug therapy, Prognosis, Thrombocythemia, Essential pathology, Time Factors, Alleles, Janus Kinase 2 genetics, Mutation, Polycythemia Vera genetics, Primary Myelofibrosis diagnosis, Primary Myelofibrosis genetics, Thrombocythemia, Essential genetics
- Abstract
Patients diagnosed with polycythemia vera (PV) or essential thrombocythemia (ET) sometimes suffer transformation of the disease into myelofibrosis (MF), which is associated with a poorer prognosis. This study investigated the prognostic value of the allele burden of JAK2V617F, a somatic driver mutation in these diseases, by comparing the allele burden between formalin-fixed paraffin-embedded bone marrow collected at initial diagnosis and peripheral blood from follow-up visits. Although the annual changes in the JAK2V617F allele burden were comparable between MF-transformed (n = 11) and untransformed (n = 23) patients, the burden was significantly increased in MF-transformed patients exhibiting a longer disease duration than untransformed patients. Furthermore, MF transformation was only observed in patients whose JAK2V617F allele burden exceeded the mean values for each disease (PV, 71.7 %; ET, 35.5 %) at initial diagnosis or during follow-up. Finally, we showed that hydroxycarbamide treatment exerted neither a preventive effect on MF transformation nor a suppressive effect on the increased JAK2V617F allele burden. In conclusion, a high JAK2V617F allele burden at initial diagnosis or during follow-up is predictive of MF transformation in PV and ET. Therefore, routine measurement of the JAK2V617F allele burden using an accurate assay system is recommended to predict MF transformation.
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- 2015
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285. Energy expenditure associated with softening and stiffening of echinoderm connective tissue.
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Motokawa T, Sato E, and Umeyama K
- Subjects
- Animals, Elasticity, Japan, Biomechanical Phenomena physiology, Connective Tissue physiology, Dermis physiology, Echinodermata physiology, Energy Metabolism physiology, Oxygen Consumption physiology
- Abstract
Catch connective tissue of echinoderms at rest (in the standard state) either stiffens or softens in response to different kinds of stimulation. The energy consumption associated with the changes was estimated by measurement of the oxygen consumption rate (VO(2)) in three types of connective tissues-echinoid catch apparatus (CA), holothuroid body-wall dermis (HD), and asteroid body-wall dermis (AD). Mechanical stimulation by repetitive compression (10%-15% strain), which increased viscosity measured by creep tests, was employed for inducing the stiff state. Noradrenaline (10(-3) mol l(-1)), which decreased viscosity of CA, and static 80% compressive strain, which decreased viscosity of HD, were used to induce the soft state in the respective tissues. The VO(2) (in μl/g/h) values of the standard state were 2.91 (CA), 1.41 (HD), and 0.56 (AD), which were less than 1/4 of the VO(2) of the resting body-wall muscle of the starfish. The VO(2) of the stiff state was about 1.5 times greater than that of the standard state in all types of connective tissues. The VO(2) of the soft state was 3.4 (CA)-9.1 (HD) times greater than that of the standard state. The economical nature of catch connective tissue in posture maintenance is discussed.
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- 2012
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286. 18F-Fluorodeoxyglucose positron emission tomography/computed tomography revealed the presence of simultaneous colon cancer in mucosa-associated lymphoid tissue lymphoma.
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Ichikawa K, Sugimoto K, Sato E, Sunami Y, Watanabe N, Ushimi T, and Komatsu N
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- Aged, Blotting, Southern, Colonoscopy, Diagnosis, Differential, Female, Fluorodeoxyglucose F18, Humans, In Situ Hybridization, Fluorescence, Radiopharmaceuticals, Colonic Neoplasms diagnostic imaging, Lymphoma, B-Cell, Marginal Zone diagnostic imaging, Mouth Neoplasms diagnostic imaging, Multimodal Imaging, Positron-Emission Tomography, Tomography, X-Ray Computed
- Published
- 2011
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287. [Hemorrhagic colitis caused by dasatinib following cytomegalovirus enterocolitis in a patient with chronic myelogenous leukemia in the second chronic phase].
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Sunami Y, Sato E, Ichikawa K, Yasuda H, and Komatsu N
- Subjects
- Adult, Dasatinib, Female, Humans, Pyrimidines therapeutic use, Thiazoles therapeutic use, Colitis etiology, Cytomegalovirus Infections, Enterocolitis etiology, Enterocolitis virology, Gastrointestinal Hemorrhage etiology, Leukemia, Myeloid, Chronic-Phase complications, Leukemia, Myeloid, Chronic-Phase drug therapy, Pyrimidines adverse effects, Thiazoles adverse effects
- Abstract
A 26-year-old female progressed to blastic crisis (BC) after three months administration of imatinib for chronic myelogenous leukemia (CML) chronic phase (CP) and was treated with a dasatinib containing chemotherapy regimen. After remission to second CP, she was hospitalized because of fever and hemorrhagic diarrhea during dasatinib maintenance therapy. She was diagnosed as having cytomegalovirus (CMV) colitis because CMV antigen in blood leukocytes was positive and CMV-positive cells were also detected on staining of an ileocecal mucosal biopsy specimen with an anti-CMV antibody. Although blood leukocyte CMV antigen and CMV staining in colonic mucosa became negative after ganciclovir treatment, hemorrhagic diarrhea did not improve. However, after discontinuance of dasatinib, hemorrhagic colitis drastically improved and did not recur after administration of nilotinib. It is possible that hemorrhagic diarrhea occurred due to dasatinib-related hemorrhagic colitis. Previous case reports have indicated that CD8-positive T-lymphocytes infiltrate the colonic mucosa in dasatinib-related hemorrhagic colitis, and the same pathological findings were seen in our case. Dasatinib may cause hemorrhagic colitis via immunological mechanisms in CML. Dasatinib-related gastrointestinal bleeding is less frequent in Japan compared to that in western countries, and Japanese cases diagnosed as having hemorrhagic colitis are extremely rare.
- Published
- 2011
288. [Case of pulmonary aspergillosis complicated with intractable nasal-type extranodal NK/T cell lymphoma].
- Author
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Sato E, Mori T, Nakamura H, and Komatsu N
- Subjects
- Amphotericin B administration & dosage, Antifungal Agents administration & dosage, Antineoplastic Agents therapeutic use, Drug Administration Schedule, Echinocandins administration & dosage, Fatal Outcome, Female, Humans, Lipopeptides administration & dosage, Liposomes, Lymphoma, T-Cell drug therapy, Lymphoma, T-Cell pathology, Maxillary Sinus Neoplasms drug therapy, Maxillary Sinus Neoplasms pathology, Micafungin, Middle Aged, Nasal Cavity, Nose Neoplasms drug therapy, Nose Neoplasms pathology, Pulmonary Aspergillosis drug therapy, Lymphoma, T-Cell complications, Maxillary Sinus Neoplasms complications, Nose Neoplasms complications, Pulmonary Aspergillosis complications
- Published
- 2011
289. Magnetic resonance imaging findings of fibroepithelial polyp of the vulva: radiological-pathological correlation.
- Author
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Kato H, Kanematsu M, Sato E, Ito N, Furui T, and Hirose Y
- Subjects
- Diagnosis, Differential, Female, Humans, Neoplasms, Fibroepithelial pathology, Polyps pathology, Vulvar Neoplasms pathology, Young Adult, Magnetic Resonance Imaging methods, Neoplasms, Fibroepithelial diagnosis, Polyps diagnosis, Vulvar Neoplasms diagnosis
- Abstract
We describe the magnetic resonance (MR) imaging findings in a 20-year-old woman with a fibroepithelial polyp of the vulva. Within the lesion, abundant fibrous tissue was visualized as stratiform hypointense areas on T2-weighted magnetic resonance imaging (MRI) scans. At the center of the attachment site, clustered fatty tissue was revealed as linear hyperintense areas on T1-weighted MRI. A mild degree of edematous stroma including less fibrosis and cellularity was demonstrated as hyperintense areas on T2-weighted MRI and hypointense areas on T1-weighted MRI. Although the MRI findings of fibroepithelial polyps of the vulva are often similar to those of aggressive angiomyxoma, angiomyofibroblastoma, and cellular angiofibroma, a fibroepithelial polyp should be considered when radiological images demonstrate the following features: stratiform hypointense areas surrounded by patchy hyperintense areas on T2-weighted MRI and hyperintense areas on T1-weighted MRI.
- Published
- 2010
- Full Text
- View/download PDF
290. Effect of itraconazole on the pharmacokinetics of everolimus administered by different routes in rats.
- Author
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Yokomasu A, Yano I, Sato E, Masuda S, Katsura T, and Inui K
- Subjects
- Animals, Antifungal Agents administration & dosage, Area Under Curve, Dose-Response Relationship, Drug, Drug Interactions, Everolimus, Immunosuppressive Agents administration & dosage, Injections, Intravenous, Intestinal Mucosa metabolism, Itraconazole administration & dosage, Liver metabolism, Male, Rats, Rats, Wistar, Sirolimus administration & dosage, Sirolimus pharmacokinetics, Antifungal Agents pharmacology, Immunosuppressive Agents pharmacokinetics, Itraconazole pharmacology, Sirolimus analogs & derivatives
- Abstract
The effect of itraconazole on the pharmacokinetics of everolimus was investigated in rats. Ten minutes after an intravenous or intraintestinal administration of itraconazole, everolimus was delivered intravenously (0.2 mg/kg) or intraintestinally (0.5 mg/kg). Blood concentrations of everolimus were measured up to 240 min, and pharmacokinetic parameters were calculated. Intraintestinally administered itraconazole (20 mg/kg) significantly increased the area under the concentration-time curve (AUC) of intraintestinally administered everolimus about 4.5-fold, but even at 50 mg/kg did not affect the AUC of intravenously administered everolimus. However, intravenously administered itraconazole (50 mg/kg) increased the AUC of both intraintestinally and intravenously administered everolimus approximately 2-fold. Using a value for hepatic blood flow from the literature (50 ml/min/kg), the apparent intestinal and hepatic extraction of everolimus without itraconazole was calculated as about 80% and 13%, respectively. Intraintestinally administered itraconazole (20 mg/kg) changed the apparent intestinal extraction by 0.26-fold from 0.829 to 0.215, but the hepatic availability of everolimus was almost unchanged after the intravenous or intraintestinal administration of itraconazole even at a dose of 50 mg/kg from 0.871 to 0.923 or 0.867, respectively. In conclusion, intraintestinally administered itraconazole dramatically increased the AUC of everolimus delivered intraintestinally by inhibiting the intestinal first-pass extraction of this drug., (Copyright 2009 John Wiley & Sons, Ltd.)
- Published
- 2009
- Full Text
- View/download PDF
291. [Evaluation of the relation between the depth of left double-lumen endobronchial tube and the patient's height--comparison between patients over 20 years of age and those under 19 years].
- Author
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Sato E, Takata M, Miyamoto Y, Hashimoto S, and Sato J
- Subjects
- Adult, Age Factors, Aged, Aged, 80 and over, Humans, Intubation, Intratracheal methods, Middle Aged, Young Adult, Body Height physiology, Respiratory System surgery
- Abstract
Background: In adult patients, there is a strong correlation between the appropriate depth of insertion of a left double-lumen endobronchial tube (DLT) and height. However, for patients with the same height, we noted the tendency of the depth of insertion being about 1 cm shorter for patients under 19 years of age compared to that for those over 20 years., Methods: We compared the depth of insertion between patients over 20 years and those under 19 years., Results: In both groups, the depth of DLT insertion correlated strongly with patient's height. For patients of the same height, the depth of insertion for those under 19 years was 0.7-1.2 cm shorter than that for patients over 20 years. For patients with a height between 160-179 cm, the mean depth of insertion for patients under 19 years was significantly shorter than that for those over 20 years., Conclusions: During intubation of the bronchi with DLT in patients under 19 years, the optimal depth of DLT insertion is less than that for patients over 20 years.
- Published
- 2009
292. Comparative genetic studies on the APRR5 and APRR7 genes belonging to the APRR1/TOC1 quintet implicated in circadian rhythm, control of flowering time, and early photomorphogenesis.
- Author
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Yamamoto Y, Sato E, Shimizu T, Nakamich N, Sato S, Kato T, Tabata S, Nagatani A, Yamashino T, and Mizuno T
- Subjects
- Arabidopsis physiology, Arabidopsis radiation effects, Morphogenesis, Mutation, Transcription Factors, Arabidopsis genetics, Arabidopsis Proteins genetics, Circadian Rhythm, Genes, Plant, Light
- Abstract
In Arabidopsis thaliana, a number of circadian-associated factors have been identified. Among those, TOC1 (TIMING OF CAB EXPRESSION 1) is believed to be a component of the central oscillator. TOC1 is a member of a small family of proteins, designated as Arabidopsis PSEUDO-RESPONSE REGULATORS (APRR1/TOC1, APRR3, APRR5, APRR7, and APRR9). Nonetheless, it is not very clear whether or not the APRR family members other than APRR1/TOC1 are also implicated in the mechanisms underlying the circadian rhythm. To address this issue further, here we characterized a set of T-DNA insertion mutants, each of which is assumed to have a severe lesion in each one of the quintet genes (i.e. APRR5 and APRR7). For each of these mutants (aprr5-11 and aprr7-11) we demonstrate that a given mutation singly, if not directly, affects the circadian-associated biological events simultaneously: (i) flowering time in the long-day photoperiod conditions, (ii) red light sensitivity of seedlings during the early photomorphogenesis, and (iii) the period of free-running rhythms of certain clock-controlled genes including CCA1 and APRR1/TOC1 in constant white light. These results suggest that, although the quintet members other than APRR1/TOC1 may not be directly integrated into the framework of the central oscillator, they are crucial for a better understanding of the molecular mechanisms underlying the Arabidopsis circadian clock.
- Published
- 2003
- Full Text
- View/download PDF
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