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CAD systems for lung cancer diagnosis and detection can significantly offer unbiased, infatiguable diagnostics with minimal variance, decreasing the mortality rate and the five-year survival rate. Lung segmentation and lung nodule detection are critical steps in the lung cancer CAD system pipeline. Literature on lung segmentation and lung nodule detection mostly comprises techniques that process 3-D volumes or 2-D slices and surveys. However, surveys that highlight 2.5D techniques for lung segmentation and lung nodule detection still need to be included. This paper presents a background and discussion on 2.5D methods to fill this gap. Further, this paper also gives a taxonomy of 2.5D approaches and a detailed description of the 2.5D approaches. Based on the taxonomy, various 2.5D techniques for lung segmentation and lung nodule detection are clustered into these 2.5D approaches, which is followed by possible future work in this direction., Competing Interests: Declaration of competing interest None Declared, (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Lung nodule segmentation is an essential step in any CAD system for lung cancer detection and diagnosis. Traditional approaches for image segmentation are mainly morphology based or intensity based. Motion-based segmentation techniques tend to use the temporal information along with the morphology and intensity information to perform segmentation of regions of interest in videos. CT scans comprise of a sequence of dicom 2-D image slices similar to videos which also comprise of a sequence of image frames ordered on a timeline. In this work, Farneback, Horn-Schunck and Lucas-Kanade optical flow methods have been used for processing the dicom slices. The novelty of this work lies in the usage of optical flow methods, generally used in motion-based segmentation tasks, for the segmentation of nodules from CT images. Since thin-sliced CT scans are the imaging modality considered, they closely approximate the motion videos and are the primary motivation for using optical flow for lung nodule segmentation. This paper also provides a detailed comparative analysis and validates the effectiveness of using optical flow methods for segmentation. Finally, we propose methods to further improve the efficiency of segmentation using optical flow methods on CT scans.