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3,922 results on '"Rosner, Bernard"'

303. Abstract P3-12-02: Loss of PTEN expression, PIK3CA mutations, and breast cancer survival in the Nurses’ health studies

Author

Wang, Tengteng, primary, Heng, Yujing J, additional, Baker, Gabrielle M, additional, Bret-Mounet, Vanessa C, additional, Hankinson, Susan E, additional, Holmes, Michelle D, additional, Chen, Wendy Y., additional, Willett, Walter C., additional, Rosner, Bernard A., additional, Tamimi, Rulla M, additional, and Eliassen, A. Heather, additional

Published
2022
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304. Abstract P3-12-01: Regular aspirin use, breast tumor characteristics and long-term breast cancer survival

Author

Peng, Cheng, primary, Holmes, Michelle D., additional, Wang, Tengteng, additional, Harris, Alexandra, additional, Chen, Wendy, additional, Brantley, Kristen, additional, Heng, Yujing J, additional, Bret-Mounet, Vanessa C., additional, Baker, Gabrielle M, additional, Rosner, Bernard, additional, Willett, Walter, additional, Tamimi, Rulla, additional, and Eliassen, A. Heather, additional

Published
2022
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308. Stability of plasma metabolomics over 10 years among women

Author

Zeleznik, Oana A, primary, Wittenbecher, Clemens, additional, Deik, Amy, additional, Jeanfavre, Sarah, additional, Avila-Pacheco, Julian, additional, Rosner, Bernard, additional, Rexrode, Kathryn M, additional, Clish, Clary B, additional, Hu, Frank B, additional, and Eliassen, A Heather, additional

Published
2022
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332. Development of a contact Lens risk survey

Author

Mitchell, G. Lynn, primary, Richdale, Kathryn, additional, Lam, Dawn, additional, Wagner, Heidi, additional, Kinoshita, Beth T., additional, Zimmerman, Aaron B., additional, Sorbara, Luigina, additional, and Rosner, Bernard, additional

Published
2021
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347. In Reply

Author

Gaskins, Audrey J., Rich-Edwards, Janet W., Missmer, Stacey A., Rosner, Bernard, and Chavarro, Jorge E.

Published
2016
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348. Loss of PTEN Expression, PIK3CA Mutations, and Breast Cancer Survival in the Nurses' Health Studies.

Author

Tengteng Wang, Heng, Yujing J., Baker, Gabrielle M., Bret-Mounet, Vanessa C., Quintana, Liza M., Frueh, Lisa, Hankinson, Susan E., Holmes, Michelle D., Chen, Wendy Y., Willett, Walter C., Rosner, Bernard, Tamimi, Rulla M., and Eliassen, A. Heather

Abstract

Background: The relationships between PTEN loss and/or PIK3CA mutation and breast cancer prognosis remain controversial. We aim to examine the associations in large epidemiologic cohorts. Methods: We followed women with invasive breast cancer from the Nurses' Health Studies with available data on tumor PTEN expression (n = 4,111) and PIK3CA mutation (n = 2,930). PTEN expression was evaluated by IHC and digitally scored (0%-100%). Pyrosequencing of six hotspot mutations of PIK3CA was performed. Results: We found loss of PTEN expression (=10%) occurred in 17% of cases, and PIK3CA mutations were detected in 11% of cases. After adjusting for clinical and lifestyle factors, PTEN loss was not associated with worse breast cancer-specific mortality among all samples [HR, 0.85; 95% confidence intervals (CI), 0.71-1.03] or among estrogen receptor (ER)-positive tumors (HR, 0.99; 95% CI, 0.79-1.24). However, among ER-negative tumors, PTEN loss was associated with lower breast cancer-specific mortality (HR, 0.68; 95% CI, 0.48-0.95). PIK3CA mutation was not strongly associated with breast cancer-specific mortality (HR, 0.89; 95% CI, 0.67-1.17). Compared with tumors without PTEN loss and without PIK3CA mutation, those with alterations (n = 540) were not at higher risk (HR, 1.07; 95% CI, 0.86-1.34). However, women with both PTEN loss and PIK3CA mutation (n = 38) were at an increased risk of breast cancer-specific mortality (HR, 1.65; 95% CI, 0.83-3.26). Conclusions: In this large epidemiologic study, the PTEN-mortality association was more pronounced for ER-negative tumors, and the joint PTEN loss and PIK3CA mutation may be associated with worse prognosis. Impact: Further studies with a larger sample of ER-negative tumors are needed to replicate our findings and elucidate underlying mechanisms. [ABSTRACT FROM AUTHOR]

Published
2022
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349. Pre-pregnancy fat intake in relation to hypertensive disorders of pregnancy.

Author

Arvizu, Mariel, Minguez-Alarcon, Lidia, Wang, Siwen, Mitsunami, Makiko, Stuart, Jennifer J, Rich-Edwards, Janet W, Rosner, Bernard, and Chavarro, Jorge E

Subjects
HYPERTENSION in pregnancy, RELATIVE medical risk, CONFIDENCE intervals, SELF-evaluation, REGRESSION analysis, RISK assessment, PREECLAMPSIA, QUESTIONNAIRES, DESCRIPTIVE statistics, OMEGA-3 fatty acids, DIETARY fats, DISEASE risk factors
Abstract

Background Many studies have linked intakes of fat and of specific fatty acids during pregnancy with preeclampsia; however, information on the association of intake before pregnancy with hypertensive disorders of pregnancy (HDP) is scant. Objectives We evaluated the associations of intakes of major and specific types of fat before pregnancy with the risks of HDP, including preeclampsia and gestational hypertension (GHTN). Methods We followed 11,535 women without chronic disease participating in the Nurses' Health Study II from 1991 and 2009. Pre-pregnancy dietary fat was assessed by an FFQ. Intakes of total fat, saturated fat, trans fatty acid (TFA), MUFAs, PUFAs, and fat subtypes (omega-3 and omega-6) were categorized into quintiles of intake. HDP were self-reported. The RRs (95% CIs) of HDP were estimated by log-binomial generalized estimating equation regression models, with an exchangeable correlation matrix to account for repeated pregnancies while adjusting for potential confounders. Results During 19 years of follow-up, there were 495 cases of preeclampsia (2.9%) and 561 (3.3%) cases of GHTN in 16,892 singleton pregnancies. The mean age at pregnancy was 34.6 years (SD, 3.9 years). Among major fat types, only pre-pregnancy TFA was related to a higher risk of HDP (RR, 1.32; 95% CI: 1.05–1.66), and only for preeclampsia (RR, 1.50; 95% CI: 1.07–2.10) but not for GHTN (RR, 1.21; 95% CI: 0.87–1.70). Among specific types of PUFAs, intake of arachidonic acid was positively related with GHTN (RR, 1.43; 95% CI: 1.00–2.04) but not preeclampsia (RR, 1.08; 95% CI: 0.75–1.57). In analyses restricted to pregnancies 1 year after the diet assessment, women with the highest intake of long-chain omega-3 fatty acids had a 31% lower risk of HDP (95% CI: 3%–51%), which was driven by preeclampsia (RR, 0.55; 95% CI: 0.33–0.92). Conclusions Pre-pregnancy intakes of total fat, saturated fat, and MUFA were unrelated to HDP, whereas TFA was positively related to HDP. These findings highlight the importance of ongoing efforts to eliminate TFA from the global food supply. [ABSTRACT FROM AUTHOR]

Published
2022
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