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8,763 results on '"Robyn M"'

301. The Critical Role of Inflammation in the Pathogenesis and Progression of Myeloid Malignancies.

Author

Craver, Brianna M, El Alaoui, Kenza, Scherber, Robyn M, and Fleischman, Angela G

Subjects
clonal hematopoiesis, hematopoietic stem cells, inflammation, myeloid malignancy, symptom burden, Stem Cell Research, Cancer, Hematology, Regenerative Medicine, 2.1 Biological and endogenous factors, Inflammatory and Immune System, Oncology and Carcinogenesis
Abstract

Hematopoietic stem cells (HSCs) maintain an organism's immune system for a lifetime, and derangements in HSC proliferation and differentiation result in hematologic malignancies. Chronic inflammation plays a contributory if not causal role in HSC dysfunction. Inflammation induces HSC exhaustion, which promotes the emergence of mutant clones that may be resistant to an inflammatory microenvironment; this likely promotes the onset of a myeloid hematologic malignancy. Inflammatory cytokines are characteristically high in patients with myeloid malignancies and are linked to disease initiation, symptom burden, disease progression, and worsened prognostic survival. This review will cover our current understanding of the role of inflammation in the initiation, progression, and complications of myeloid hematologic malignancies, drawing from clinical studies as well as murine models. We will also highlight inflammation as a therapeutic target in hematologic malignancies.

Published
2018

302. Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis

Author

Langer-Gould, Annette, Lucas, Robyn M, Xiang, Anny H, Wu, Jun, Chen, Lie H, Gonzales, Edlin, Haraszti, Samantha, Smith, Jessica B, Quach, Hong, and Barcellos, Lisa F

Subjects
Prevention, Multiple Sclerosis, Autoimmune Disease, Clinical Research, Neurodegenerative, Brain Disorders, Neurosciences, Nutrition, Genetics, Neurological, Adult, African Americans, Female, Genotype, Hispanic or Latino, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, Sunlight, Vitamin D, Vitamin D-Binding Protein, Whites, multiple sclerosis, vitamin D, polymorphisms, blacks, Hispanics, White People, Black or African American, Food Sciences, Nutrition and Dietetics
Abstract

Blacks have different dominant polymorphisms in the vitamin D-binding protein (DBP) gene that result in higher bioavailable vitamin D than whites. This study tested whether the lack of association between 25-hydroxyvitamin D (25OHD) and multiple sclerosis (MS) risk in blacks and Hispanics is due to differences in these common polymorphisms (rs7041, rs4588). We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from Kaiser Permanente Southern California. AA is the dominant rs7041 genotype in blacks (70.0%) whereas C is the dominant allele in whites (79.0% AC/CC) and Hispanics (77.1%). Higher 25OHD levels were associated with a lower risk of MS in whites who carried at least one copy of the C allele but not AA carriers. No association was found in Hispanics or blacks regardless of genotype. Higher ultraviolet radiation exposure was associated with a lower risk of MS in blacks (OR = 0.06), Hispanics and whites who carried at least one copy of the C allele but not in others. Racial/ethnic variations in bioavailable vitamin D do not explain the lack of association between 25OHD and MS in blacks and Hispanics. These findings further challenge the biological plausibility of vitamin D deficiency as causal for MS.

Published
2018

306. Environmental plastics in the context of UV radiation, climate change, and the Montreal Protocol

Author

Jansen, Marcel A. K., primary, Andrady, Anthony L., additional, Barnes, Paul W., additional, Busquets, Rosa, additional, Revell, Laura E., additional, Bornman, Janet F., additional, Aucamp, Pieter J., additional, Bais, Alkiviadis F., additional, Banaszak, Anastazia T., additional, Bernhard, Germar H., additional, Bruckman, Laura S., additional, Häder, Donat‐P., additional, Hanson, Mark L., additional, Heikkilä, Anu M., additional, Hylander, Samuel, additional, Lucas, Robyn M., additional, Mackenzie, Roy, additional, Madronich, Sasha, additional, Neale, Patrick J., additional, Neale, Rachel E., additional, Olsen, Catherine M., additional, Ossola, Rachele, additional, Pandey, Krishna K., additional, Petropavlovskikh, Irina, additional, Robinson, Sharon A., additional, Robson, T. Matthew, additional, Rose, Kevin C., additional, Solomon, Keith R., additional, Sulbæk Andersen, Mads P., additional, Sulzberger, Barbara, additional, Wallington, Timothy J., additional, Wang, Qing‐Wei, additional, Wängberg, Sten‐Åke, additional, White, Christopher C., additional, Young, Antony R., additional, Zepp, Richard G., additional, and Zhu, Liping, additional

Published
2024
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308. Metabolic pathways of glucose and fructose: II Spatiotemporal expression of genes involved in synthesis and transport of lactate in ovine conceptuses

Author

Moses, Robyn M, primary, Stenhouse, Claire, additional, Halloran, Katherine M, additional, Sah, Nirvay, additional, Newton, Makenzie G, additional, Hoskins, Emily C, additional, Washburn, Shannon E, additional, Johnson, Gregory A, additional, Wu, Guoyao, additional, and Bazer, Fuller W, additional

Published
2024
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310. FIGURE 6 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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311. FIGURE 5 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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312. Supplementary Figure 1 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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313. Supplementary Table 4 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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314. FIGURE 4 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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315. USDA diet educational materials from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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316. Supplementary Table 2 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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317. Data from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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318. The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, additional, Nguyen, Hellen, additional, Nguyen, Jenny, additional, Soyfer, Eli M., additional, Liu, Jiarui, additional, Chen, Jane H., additional, Mehrotra, Nitya, additional, Huang, Xin, additional, Kosiorek, Heidi E., additional, Dueck, Amylou, additional, Himstead, Alexander, additional, Heide, Elena, additional, Lem, Melinda, additional, El Alaoui, Kenza, additional, Mas, Eduard, additional, Scherber, Robyn M., additional, Mesa, Ruben A., additional, Whiteson, Katrine L., additional, Odegaard, Andrew, additional, and Fleischman, Angela G., additional

Published
2024
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319. Supplementary Figure 2 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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320. FIGURE 3 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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321. TABLE 1 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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322. Supplementary Figure 3 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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323. Mediterranean Diet education materials from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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324. FIGURE 1 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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325. Supplementary Table 1 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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326. TABLE 2 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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327. FIGURE 2 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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328. Surveys from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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329. Supplementary Table 3 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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330. Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function

Author

Jang, Gwendolyn M., primary, Annan Sudarsan, Arun Kumar, additional, Shayeganmehr, Arzhang, additional, Prando Munhoz, Erika, additional, Lao, Reanna, additional, Gaba, Amit, additional, Granadillo Rodríguez, Milaid, additional, Love, Robin P., additional, Polacco, Benjamin J., additional, Zhou, Yuan, additional, Krogan, Nevan J., additional, Kaake, Robyn M., additional, and Chelico, Linda, additional

Published
2024
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331. Prevalence and predictors of vitamin D deficiency in a nationally representative sample of Australian adolescents and young adults

Author

Horton-French, Kahlea, Dunlop, Eleanor, Lucas, Robyn M., Pereira, Gavin, and Black, Lucinda J.

Subjects
Young adults -- Health aspects, Vitamin D deficiency -- Statistics -- Demographic aspects -- Risk factors, Teenagers -- Health aspects, Youth -- Health aspects, Food/cooking/nutrition, Health
Abstract

Background/Objectives Vitamin D deficiency is a public health concern worldwide. Maintaining vitamin D sufficiency during growth periods is essential. We aimed to determine the prevalence and predictors of vitamin D deficiency in Australian adolescents and young adults. Subject/Methods We used data from adolescents (12-17 years, n = 692) and young adults (18-24 years, n = 400) who participated in the nationally representative 2011-2013 Australian Health Survey. Serum 25-hydroxyvitamin D concentrations were measured using a method certified to international standards, with prevalence reported for 125 nmol/L. Independent predictors of vitamin D deficiency were determined using a survey-weighted Poisson regression model. Results Overall, 17% of adolescents and 32% of young adults were vitamin D deficient. In models adjusted for sex, age, region of birth, socioeconomic status, BMI and season (and education, smoking status and physical activity in young adults only), the prevalence ratio (PR) for vitamin D deficiency was more than double in participants born outside Australia (adolescents: PR 2.46; 95% confidence interval (CI) = 1.59, 3.81; young adults: PR 2.12; 95% CI = 1.46, 3.07), and also varied by season (adolescents: spring vs summer PR 2.47; 95% CI = 1.22, 5.01 and winter vs summer PR 2.01; 95% CI = 1.03, 3.92; young adults: winter vs summer; PR 3.32; 95% CI = 1.69, 6.53). Other predictors of vitamin D deficiency were overweight compared with healthy weight (adolescents) and lower physical activity (young adults). Conclusions Strategies based on safe sun exposure and dietary approaches are needed to achieve and maintain adequate vitamin D status, particularly in young adults., Author(s): Kahlea Horton-French [sup.1] , Eleanor Dunlop [sup.1] , Robyn M. Lucas [sup.2] [sup.3] , Gavin Pereira [sup.1] [sup.4] [sup.5] , Lucinda J. Black [sup.1] Author Affiliations: (1) Curtin School [...]

Published
2021
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332. Demographic and clinical predictors of vitamin D status in pregnant women tested for deficiency in Western Australia

Author

Miller, Kate M., De Klerk, Nick H., Davis, Elizabeth A., Lucas, Robyn M., Hart, Prue H., and Haynes, Aveni

Subjects
Vitamin D deficiency -- Diagnosis -- Demographic aspects -- Risk factors, Pregnant women -- Health aspects, Health
Abstract

: Objective: This study aimed to describe the vitamin D status of pregnant women in Western Australia and identify predictors of deficiency in pregnancy. Methods: A cross‐sectional study was conducted using linked data from statewide administrative data collections. Participants included pregnant women aged 18–44 years who gave birth between 2012 and 2014. Results: The mean 25‐hydroxyvitamin D (25[OH]D) concentration was 70.7 nmol L[sup.−1] (SD 25.7; range 5–255 nmol L[sup.−1]). Approximately one‐fifth of the pregnant women were vitamin D deficient ( Conclusions: In addition to the existing risk factors for deficiency, maternal age was an independent predictor of vitamin D deficiency. There was a large discrepancy between the time of first antenatal visit and screening for vitamin D deficiency. Implications for public health: Our findings support the addition of maternal age (under 25 years) to the current clinical guidelines for targeted screening of 25(OH)D levels in pregnancy and the practical application of screening for vitamin D deficiency at the first antenatal visit., Vitamin D deficiency during pregnancy has been associated with increased risks of pre‐eclampsia, gestational diabetes, caesarean section, low birthweight and preterm birth (for review[sup.1]). Supplementation trials have shown some promising [...]

Published
2021
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333. Teaching Play Skills through the Use of Assistive Technology and Instructional Strategies: A National Survey

Author

Johnston, Susan S. and Thompson, Robyn M.

Abstract

Play is often considered the main occupation of early childhood. Despite the importance of play, young children with disabilities may not achieve the same experiences as their typically developing counterparts. Literature supports the use of specific instructional strategies to promote the acquisition of play skills. In addition to utilizing specific instructional strategies to teach play skills, assistive technology (AT) can support positive outcomes. The authors conducted a survey study in order to advance our understanding of early childhood special education professionals' knowledge and use of instructional strategies and AT to teach play skills to young children with disabilities. The participants' reported knowledge and use of instructional strategies to teach play skills to young children with disabilities was high relative to their knowledge and use of AT. Furthermore, early childhood special education professionals reported that they did not vary their use of instructional strategies based on the AT tool. Implications of these finding for research and practice are discussed.

Published
2015

338. Is the current public health message on UV exposure correct?

Author

Robyn M Lucas, Mike H Repacholi, and Anthony J McMichael

Subjects
Public aspects of medicine, RA1-1270
Abstract

Current sun safety messages stress the importance of sun protection in avoiding the consequences of excessive exposure to ultraviolet radiation (UVR), such as skin cancers, cataracts and other eye diseases, and viral infections caused by UV-induced immunosuppression. However, adequate exposure to UVR has an important role in human health, primarily through UV-induced production of vitamin D, a hormone essential to bone health. Vitamin D insufficiency may be associated with increased risks of some cancers, autoimmune diseases and mental health disorders such as schizophrenia. Here, we review the evolution of current sun exposure practices and sun-safe messages and consider not only the benefits, but also the detrimental effects that such messages may have. UVR-induced vitamin D production can be inhibited by factors such as deep skin pigmentation, indoor lifestyles, older age, sun avoidance behaviours and clothing habits that limit skin exposure, with deleterious consequences for health. There is some early evidence that sun-safe messages are beginning to cause a decrease in skin cancer rates in young people. After the widespread promotion of sun safety, it may now be appropriate to refine public health messages to take better account of variations between groups and their susceptibility to the dangers and benefits of sun exposure.

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342. BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia

Author

Carrington, Emma M., Louis, Cynthia, Kratina, Tobias, Hancock, Manuela, Keenan, Christine R., Iannarella, Nadia, Allan, Rhys S., Wardak, Ahmad Z., Czabotar, Peter E., Herold, Marco J., Schenk, Robyn L., White, Christine A., D'Silva, Damian, Yang, Yuyan, Wong, Wesley, Wong, Huon, Bryant, Vanessa L., Huntington, Nicholas D., Rautela, Jai, Sutherland, Robyn M., Zhan, Yifan, Hansen, Jacinta, Nhu, Duong, Lessene, Guillaume, Wicks, Ian P., and Lew, Andrew M.

Published
2021
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345. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

Author

Judge, Luke M, Perez-Bermejo, Juan A, Truong, Annie, Ribeiro, Alexandre Js, Yoo, Jennie C, Jensen, Christina L, Mandegar, Mohammad A, Huebsch, Nathaniel, Kaake, Robyn M, So, Po-Lin, Srivastava, Deepak, Pruitt, Beth L, Krogan, Nevan J, and Conklin, Bruce R

Subjects
Cardiology, Cell Biology
Abstract

Molecular chaperones regulate quality control in the human proteome, pathways that have been implicated in many diseases, including heart failure. Mutations in the BAG3 gene, which encodes a co-chaperone protein, have been associated with heart failure due to both inherited and sporadic dilated cardiomyopathy. Familial BAG3 mutations are autosomal dominant and frequently cause truncation of the coding sequence, suggesting a heterozygous loss-of-function mechanism. However, heterozygous knockout of the murine BAG3 gene did not cause a detectable phenotype. To model BAG3 cardiomyopathy in a human system, we generated an isogenic series of human induced pluripotent stem cells (iPSCs) with loss-of-function mutations in BAG3. Heterozygous BAG3 mutations reduced protein expression, disrupted myofibril structure, and compromised contractile function in iPSC-derived cardiomyocytes (iPS-CMs). BAG3-deficient iPS-CMs were particularly sensitive to further myofibril disruption and contractile dysfunction upon exposure to proteasome inhibitors known to cause cardiotoxicity. We performed affinity tagging of the endogenous BAG3 protein and mass spectrometry proteomics to further define the cardioprotective chaperone complex that BAG3 coordinates in the human heart. Our results establish a model for evaluating protein quality control pathways in human cardiomyocytes and their potential as therapeutic targets and susceptibility factors for cardiac drug toxicity.

Published
2017

346. Climate change-induced increases in precipitation are reducing the potential for solar ultraviolet radiation to inactivate pathogens in surface waters

Author

Williamson, Craig E, Madronich, Sasha, Lal, Aparna, Zepp, Richard G, Lucas, Robyn M, Overholt, Erin P, Rose, Kevin C, Schladow, S Geoffrey, and Lee-Taylor, Julia

Subjects
Earth Sciences, Atmospheric Sciences, Climate-Related Exposures and Conditions, Good Health and Well Being, Climate Action, Climate Change, Disease Outbreaks, Humans, Lakes, Models, Theoretical, Organic Chemicals, Rain, Rivers, Seasons, Solar Energy, Surface Properties, Ultraviolet Rays, Water Microbiology
Abstract

Climate change is accelerating the release of dissolved organic matter (DOM) to inland and coastal waters through increases in precipitation, thawing of permafrost, and changes in vegetation. Our modeling approach suggests that the selective absorption of ultraviolet radiation (UV) by DOM decreases the valuable ecosystem service wherein sunlight inactivates waterborne pathogens. Here we highlight the sensitivity of waterborne pathogens of humans and wildlife to solar UV, and use the DNA action spectrum to model how differences in water transparency and incident sunlight alter the ability of UV to inactivate waterborne pathogens. A case study demonstrates how heavy precipitation events can reduce the solar inactivation potential in Lake Michigan, which provides drinking water to over 10 million people. These data suggest that widespread increases in DOM and consequent browning of surface waters reduce the potential for solar UV inactivation of pathogens, and increase exposure to infectious diseases in humans and wildlife.

Published
2017

347. A user's guide for the International Classification of Cognitive Disorders in Epilepsy

Author

Hermann, Bruce, Busch, Robyn M., Reyes, Anny, Arrotta, Kayela, Fujikawa, Mayu, Ives‐Deliperi, Victoria, Dollman, Aimee, Shah, Urvashi, and McDonald, Carrie R.

Abstract

To present the background, rationale, details pertaining to use and essential computational steps, synopsis of findings to date, and future directions for the International Classification of Cognitive Disorders in Epilepsy (IC‐CoDE)—an initiative of the ILAE Neuropsychology Task Force. Examined are: (a) the 6 steps leading to the derivation of a cognitive phenotype from neuropsychological test data with an accompanying case example, (b) concise review of all IC‐CoDE research to date, (c) summary of identified correlates of IC‐CoDE outcomes, and (d) future research and clinical directions for the initiative. The IC‐CoDE is computationally uncomplicated with individual or group data and represents a novel approach leading to new insights in the neuropsychology of epilepsy, with applications to diverse datasets internationally informing the reliability and validity of the approach. The IC‐CoDE represents a novel approach to the analysis and interpretation of neuropsychological data in epilepsy that offers to advance a global taxonomy of cognitive disorders in epilepsy facilitating international collaboration and big data science.

Published
2024
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348. Pathogenic hypothalamic extracellular matrix promotes metabolic disease

Author

Beddows, Cait A., Shi, Feiyue, Horton, Anna L., Dalal, Sagar, Zhang, Ping, Ling, Chang-Chun, Yong, V. Wee, Loh, Kim, Cho, Ellie, Karagiannis, Chris, Rose, Adam J., Montgomery, Magdalene K., Gregorevic, Paul, Watt, Matthew J., Packer, Nicolle H., Parker, Benjamin L., Brown, Robyn M., Moh, Edward S. X., and Dodd, Garron T.

Abstract

Metabolic diseases such as obesity and type 2 diabetes are marked by insulin resistance1,2. Cells within the arcuate nucleus of the hypothalamus (ARC), which are crucial for regulating metabolism, become insulin resistant during the progression of metabolic disease3–8, but these mechanisms are not fully understood. Here we investigated the role of a specialized chondroitin sulfate proteoglycan extracellular matrix, termed a perineuronal net, which surrounds ARC neurons. In metabolic disease, the perineuronal net of the ARC becomes augmented and remodelled, driving insulin resistance and metabolic dysfunction. Disruption of the perineuronal net in obese mice, either enzymatically or with small molecules, improves insulin access to the brain, reversing neuronal insulin resistance and enhancing metabolic health. Our findings identify ARC extracellular matrix remodelling as a fundamental mechanism driving metabolic diseases.

Published
2024
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