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Benzo-condensed four-ring heterocycles, such as benzoxetes 1 and benzothietes 3 represent multi-purpose starting compounds for the preparation of various higher heterocyclic ring systems. The thermal or photochemical valence isomerizations between the benzenoid forms 1,3 and the higher reactive o-quinoid structures 2,4 provide the basis for the synthetic applications. On the other hand, this valence isomerization impedes in particular the generation and storage of 1 because the thermal equilibrium 1 ⇆ 2 is completely on the side of 2. Thus, the number of erroneous or questionable benzoxete structures published to date is surprisingly high. On the contrary, the thermal equilibrium 3 ⇆ 4 is on the side of the benzothietes 3, which makes them easily accessible, especially by different flash vacuum pyrolysis techniques. The present article gives a survey of the preparations of 1 and 2, and tries to stimulate their use in synthetic projects. Naphtho-condensed and higher condensed compounds and compounds with an exocyclic C=O or S=O double bond (lactones, thiolactones, sulfoxides and sulfones) are not covered in this article.

A general synthetic route to prepare all four carboline regioisomers by photostimulated cyclization of anilinohalopyridines is described. The methodology affords various substituted carbolines in good to excellent yields. In the case of α-carbolines, the S(RN)1 methodology complements previously reported palladium-catalyzed cyclization approaches. Fil: Laha, Joydev K.. Harvard Medical School; Estados Unidos Fil: Barolo, Silvia Maricel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Rossi, Roberto Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Cuny, Gregory D.. Harvard Medical School; Estados Unidos

Cascade cyclization of bromoenynes bearing an aryl group with catalytic amounts of palladium(II) acetate and cesium carbonate led to the direct construction of tri- or tetracyclic heterocycles. Direct arylation of a pyrrole, furan or thiophene ring in the cascade reaction affords the corresponding fused heteroarenes in moderate to good yields.

A number of conceptually new synthetic approaches to the elaboration of constitutionally diverse isoindolinones have been disclosed. The main objective was to develop synthetic tactics for the creation of the lactam unit that would allow for incorporation of appropriate functionalities liable to give access to an array of synthetic, natural and/or bioactive compounds through rather simple chemical manipulation. The flexibility and potentiality of these new processes have been further exemplified by the total synthesis of exemplary representatives in both series, i.e. alkaloids and compounds endowed with chemotherapeutic properties.

The synthesis of a series of substituted 9H-carbazoles by the photostimulated SRN1 substitution reactionwith diarylamines as starting substrate was performed. The diarylamines were obtained by two approaches,the Pd-catalyzed reactions (Buchwald-Hartwig) or Cu-catalyzed reactions of 2-haloanilines with aryl halides, or 2-bromoiodobenzene with anilines, with moderate to very good isolated yields (45-89%).Through an intramolecular C-C bond formation of diarylamines by the SRN1 mechanism, Carbazoles were achieved. These reactions proceeded synthetically in very good to excellent yields (81-99%) in liquid ammonia and DMSO. The reaction of N-(2-bromophenyl)-2-phenylbenzenamine gave 1-phenyl-9H-carbazole (38%) and the isomer 9H-tribenz[b,d,f]azepine (58%). By using this methodology, 9Hcarbazoles, substituted 9H-carbazoles, benzocarbazoles, and even 3,3′-bi(9H-carbazole) were obtained by a double SRN1 reaction with benzidine. Fil: Buden, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Vaillard, Victoria Anahi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Martín, Sandra Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Rossi, Roberto Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina

A new and unexpected Rh(I)-catalyzed cycloisomerization of 1,6-enynes is reported. Several different alkyne substitution patterns were evaluated under the reaction conditions, including a deuterated derivative that provides some insight into the reaction mechanism.

A novel stereocontrolled approach has been developed for the syntheses of tashiromine and epitashiromine alkaloids from cyclooctene β-amino acids. The synthetic concept is based on the azetidinone opening of a bicyclic β-lactam, followed by oxidative ring opening through ring C–C double bond and reductive ring-closure reactions of the cis- or trans-cyclooctene β-amino acids.

A simple and stereospecific synthesis of both (R)- and (S)-GABOB has been developed. The synthetic approach involves the conversion, through organoselenium intermediates, of commercially available ethyl (R)- and (S)-4-chloro-3-hydroxybutyrate into a protected 1,2-amino alcohol with retention of the original configuration.

New convenient methods for the synthesis of 1,2,3-thiadiazole, 1,3,4-thiadiazine, and 1,2,5-triazepine derivatives are reported. In the heterocyclization process, the reactivity of 1-thia-4-aza-1,3-butadiene system of syn-2-phenylhydrazono-3-oxothiobutanoic acid anilides was exploited.

Whereas the biomimetic oxidative N-dealkylation of tertiary amines with t-BuOOH and an iron(III) tetraphenylporphyrin typically proceeds by an electron transfer (ET) route, a radical H-atom transfer (HAT) route has been found to operate with N-benzylaziridine (1), an amine that is fairly resistant towards one-electron oxidation for steric reasons. New mechanistic information is presented in favour of this radical route, and the exclusive formation of the dimeric product N,N′-dibenzylpiperazine (2) is explained in the light of the Baldwin's rules. Flash photolysis data provide a rate constant of 1.7 × 105 s−1 for the ring opening of the aziridine radical (1.) to the imine radical (4.) in the early stages of the process leading to 2. Semiempirical calculations indicate the ring-opened radical 4. to be more stable than 1.. Copyright © 2002 John Wiley & Sons, Ltd.

The nucleophilic substitution of substituted o-nitrochlorobenzenes with substituted methanethiolates, catalysed with triethylamine or pyridine, has been used to prepare a series of appropriately substituted methyl-o-nitrophenylsulfides. The prepared compounds were identified by their 1H- and 13C-NMR spectra. The base catalysed ring closure of methyl 2-(methoxycarbonylmethylsulfanyl)-3,5-dinitrobenzenecarboxylate only results in an attack of carbanion on the ester group, not on a nitro group as with the other compounds prepared. The cyclisation product is methyl 3-hydroxy-5,7-dinitro-benzo[b]thiophene-2-carboxylate (11).

Acylation of 2-aminothiobenzamide or 2-methylaminothiobenzamide with substituted benzoyl chlorides has been used to synthesise the corresponding 2-benzoyl-aminothiobenzamides whose subsequent sodium methoxide-catalysed ring closure gives the corresponding quinazoline-4-thiones. These compounds were characterised by means of their 1H- and 13C-NMR spectra. The preferred tautomeric form of selected compounds has been discussed on the basis of their 13C-NMR, IR and Raman spectra. It has been found that in the given medium 1-methyl-quinazoline-4-thiones undergo a replacement of the sulphur substituent by oxygen giving 1-methyl-quinazoline-4-ones. In strong acid media, 2-benzoylaminothiobenzamide is cyclised through its sulphur atom to give 2-phenylbenzo[d-1,3]thiazin-4-one.

Novel synthesis of 1,3-disilacyclohexanes is achieved by silylation of bis(alkylthio)methyllithium with chloro(chloromethyl)dimethylsilane followed by ring closure with a base. The spiro-fused disilacyclohexane ring is shown to be structurally strain-free, like cyclohexane. A reaction mechanism is proposed involving a silacyclopropane intermediate whose electrophilic reactivity at silicon is supported by ab initio calculation.

This account describes our studies on the synthesis of natural products that contain cyclic ethers in their structures. An overview of the main methodologies is presented and several total syntheses developed by the group are described. We also discuss new applications based on the use of Prins and Nicolas reactions as key steps in the preparation of oxygenated heterocyclic compounds., This research was supported by the Spanish MINECO, co-financed by the European Regional Development Fund (ERDF) (CTQ2011- 28417-C02-01/BQU and CTQ2011-22653) and the IMBRAIN project (FP7-REGPOT-2012-CT2012-31637-IMBRAIN), which is funded under the Seventh Framework Programme (CAPACITIES).

Bu çalışmada yeni kinoksalin türevlerinin sentezi tanımlanmıştı. İlk olarak, izonitrosoasetofenon, izonitroso-1-asetilnaftalin ve izonitroso-4-asetilbifenil bileşikleri, izopentil nitrit ile sırasıyla asetofenon, 1-asetilnaftalin ve 4-asetilbifenil bileşiklerinin reaksiyonundan elde edilmiştir. Daha sonra o-fenilendiamin türevleri ile elde edilen bu keto oksim bileşiklerinin kondensasyon reaksiyonlarından farklı kinoksalin türevleri sentezlenmiştir. Sentezlenen kinoksalin türevlerinin yapıları FT-IR, 1H-NMR ve 13C-NMR teknikleri kullanılarak aydınlatılmıştır., This study describes the synthesis of novel quinoxaline derivatives. Firstly, isonitrosoacetophenone, isonitroso-1-acetylnaphthalene and isonitroso-4-acetylbiphenyl were synthesized from the reaction of isopentylnitrite with acetophenone, 1-acetylnaphthalene and 4-acetylbiphenyl respectively. Then, derivatives of quinoxaline were prepared from the condensation reaction of keto oximes with derivatives of o-phenylenediamine. Structures of the obtained products were confirmed by FT-IR, 1H-NMR and 13C-NMR techniques., Bu tez çalışması BAP tarafından 11201002 nolu proje ile desteklenmiştir.

This Account describes our work on highly electrophilic γ-carbonyl cations featuring propargyldicobalt cations, cycloheptynedicobalt complexes, and the interconnection between the two systems. 1 Introduction 2 γ-Carbonyl Cations via Iron Allyl Cations 3 γ-Carbonyl Cations via Propargyldicobalt Cations 3.1 Synthesis of Velloziolide 3.2 Synthesis of Microstegiol 4 Synthesis of Cycloheptynedicobalt Complexes 4.1 Synthesis via γ-Carbonyl Cations 4.2 Cycloheptynedicobalt Complexes via [4+3] Cycloaddition Reactions 4.3 Cycloheptynedicobalt Complexes via Ring-Closing Meta­thesis 4.4 Cycloaddition Reactions on Cycloheptynedicobalt Complexes 4.5 Cycloheptynedicobalt Complexes via Intramolecular ­Nicholas Reactions 5 Dehydrotropylium Ion Co2(CO)6 Complex 6 Final Comments

A simple and general “one pot” procedure for the synthesis of 2,9-diarylpurines with one or multiple hydroxyl groups in the 2- aryl unit is described, from the reaction of 5-amino-4-amidinoimidazoles with phenolic aldehydes., National NMR Network, Fundação para a Ciência e a Tecnologia (FCT). F.C.T. (project nºF-COMP-01-0124-FEDER-022716 (ref. FCT PEst-/QUI/UI0686/2011) FEDER-COMPETE, FCT-Portugal and the PhD grant to C. Correia (SFRH/BD/22270/2005).

International audience; An easy and mild copper(I)-catalysed lactonisation of readily available (E)-2,3-dihalopropenoic acid derivatives regio- and stereoselectively leads to rarely described (Z)-3-halo-5-ylidene-5H-furan-2-ones. These compounds are subsequently able to undergo classical Pd-catalysed cross-coupling reactions, providing 3-substituted and 3,4-disubstituted 5-ylidene-5H-furan-2-ones

International audience; The synthesis of a series of benzo(iso)quinoline and phenanthroline derivatives has been achieved using an efficient one-pot procedure. It proceeds through a Suzuki–Miyaura cross-coupling followed by a Dieckmann–Thorpe ring closure under microwave irradiation and provides easy access to building blocks not readily available through other methods

International audience; A one-pot synthesis of novel poly-substituted phenanthrenes is described in this article through a Suzuki–Miyaura cross-coupling followed by a Dieckmann–Thorpe ring closure under microwave irradiation. The selection of the appropriate starting materials allowed us to introduce diversity on various positions of the phenanthrene ring system

Blatters radical, 1,3-diphenyl-1,4-dihydro-1,2,4-benzotriazin-4-yl (1a, R =H), and several of its C-7 substituted analogues (R =CF3, Cl, Br, I, Me, OMe) were prepared in good-to-excellent yields through catalytic oxidation of the corresponding amidrazones by using palladium-on-carbon (1.6 mol%) and 1,8-diazabicyclo[5.4.0]undec-7-ene (0.1-1.0 equiv) in air. The reaction conditions were suitable for the preparation of Blatters radical on a one-gram scale in up to 87% yield. © Georg Thieme Verlag Stuttgart. 12 2075 2079 Cited By :36

Collision-induced activation of deprotonated trimethylamine N-oxide yields the two anions [N(CH(2))(3)](-) and [ON(CH(2))(2)](-) following losses of H(2)O and CH(4), respectively. These two anions decompose by minor losses of H(*) and H(2) when collisionally activated: no other fragmentations are noted. Calculations at the CCSD(T)/aug-cc-pVDZ//B3LYP/6-31+G(d) level of theory indicate that these trigonal anions are stable, and should not rearrange following collisional activation. Collisional-induced charge stripping of the anions [N(CH(2))(3)](-) and [ON(CH(2))(2)](-), respectively, form N(CH(2))(3) and ON(CH(2))(2). Some of these neutrals are energised and undergo rearrangement and dissociation. From a consideration of experiment and theory, it is proposed (i) that energised N(CH(2))(3) may cyclise to form the 1-aziridinylcarbinyl radical. This species may ring open to CH(2)=NCH(2)CH(2) which then decomposes to CH(2)N and C(2)H(4) and (ii) energised ON(CH(2))(2) may undergo OC cyclisation followed by ring opening to energised CH(2)=NCH(2)O which may fragment to yield CH(2)N and CH(2)O.

Quinones are an important class of naturally occurring compounds, which demonstrate antimicrobial and anticancer activities. In view of their biological activity, especially the quinones bearing N-heterocyclic rings have elicited considerable interest. Tetrahydroisoquinoline-5,8-diones and isoquinoline-5,8-diones have been used as a structural template for the synthesis of naturally occurring potent antibiotics such as saframycins, lemonomycin and bostrycoidin. Also the isoindole analogues, such as bhimamycin C and bhimamycin D, display a wide range of biological effects. Although the (tetrahydro)benzo[g]isoquinoline-5,10-diones and benzo[f]isoindole-4,9-diones have attracted considerable attention in literature, to date only a limited number of synthetic pathways was developed, and none of these addresses the construction of 2-substituted 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones. We developed a general synthetic strategy for these classes of compounds, which consists of the synthesis of a 1,4-naphthoquinone (or a 1,4-dimethoxynaphthalene in case of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones), containing a N-protected aminoalkyl group at C-3 and a leaving group at the C-2-methylene group. An intramolecular substitution, an optional N-alkylation and a subsequent oxidation afford the desired target compounds.

Summary The first synthesis of 2,3,6,7-tetrabromoanthracene is presented, starting from benzene in a straightforward four step synthesis.

2-(Alkenyloxy)naphthalene-l-carbaldehyde oximes are oxidized with potassium iodide, iodine and sodium bicarbonate directly to novel naphthopyranoisoxazoles. Naphthopyranoisoxazoles are also prepared from 2-(3-chloroallyloxy)napbthalene-1-carbaldehyde oxime or 2-(alkynyloxy)naphthalene-1-carbaldehyde oximes by oxidation with sodium hypochlorite and triethylamine. The oxidation of 2-(alkenyloxy)naphthatene-1-carbaldehyde oximes with sodium hypochlorite and triethylamine afforded novel naphthopyranoisoxazolines. The former reaction is tentatively proposed to occur via activation of the alkene side chain by means of an iodonium intermediate and either 1,3-dipolar interaction with a nitrile oxide side-group or cyclization with a hydroximic acid iodide side-group. Synthesis-Stuttgart

An efficient route towards the synthesis of a conformationally constrained phenylalanine derivative is demonstrated using the strategic combination of ring-closing enyne metathesis and Diels-Alder reaction as key steps.

5 pages.-- et al., In search for novel heterocyclization processes, the intramolecular Pd-mediated allylic alkylation of homoallyl hydroxyl­amines is described. Depending on both the reaction conditions and the substrates, cis- or trans-3-substituted-5-vinyl isoxazolidines are preferentially obtained. The corresponding starting materials for the cyclization step are readily obtained through cross-metathesis of the easily accessible unsubstituted homoallyl hydroxylamines., This study was supported by the Ministerio de Educacion y Ciencia (MEC) and FEDER Program (Madrid, Spain, project CTQ2004-0421/BQU) and the Gobierno de Aragón (Zaragoza, Spain). V.M. thanks MEC for a FPU predoctoral grant.

Ring closure and ring opening reactions are in many cases useful synthetic procedures in organic chemistry. They allow the preparation of complex molecules with high stereoselectivity and good yields. Mechanistic and theoretical studies have been carried out on the transformation of 2-aminopyrimidines into imidazo[1,2-c]pyrimidines and guanidines, respectively, through ring closure and ring opening reactions, as well as the transamidation reactions through the ring closure and ring opening of guanidine derivatives, which constitute novel synthetic methods. Sepulveda Arques, Jose, Jose.Sepulveda@uv.es

communication; International audience; A study concerning the gold(I) catalyzed rearrangement of propargylic tert-butylcarbamates into 5-methylene-oxazolidin-2-ones is described. The mild reaction conditions employed allow the efficient synthesis of a variety of these structures which would be less conveniently obtained using other reported methods.

The A ring of hexacyclinic acid has been synthesised, using a ring-closing metathesis involving an alpha-EWG-substituted enone as the key step. We have then explored the scope of this reaction, which gives access to various 5- and 6-membered rings.

3-Alkyl-thiazolo[3,2-a]benzimidazole derivatives are obtained in high yields via the corresponding 4-alkyl- N -3-(2-aminophenyl)-thiazoline-2-thiones which are easily prepared from 1,2-diaminobenzene, CS 2 and halogenoketones. This new route compares advantageously with the classical mercaptobenzimidazole routes in term of simplicity, isolated yields and availability of the starting materials. Keywords: 2-Methylthiothiazolium salts, fused heterocycles, ring closure. Introduction 3-Methyl-thiazolo[3,2-a]benzimidazole ( 1a ) is available for screening purposes in three libraries according to Chem. Abstracts. So far the reported synthetic routes leading to thiazolo[3,2-a]benzimidazole skeleton begin from the preformed 2-mercaptobenzimidazole which is condensed at the mercapto-group with various electrophiles such as alpha-haloketones [1], propargyl halides [2] or 1,2,3-tribromopropane [3] followed by cyclization to form the thiazole ring in the last step (Scheme 1). Scheme 1 NNSR

Five suitably protected enantiomerically pure beta(2)-amino acids, homologues of proteinogenic alpha-amino acids, were synthesized from the common chiral precursor, tert-butyl succinyloxazolidinone.

En esta tesis se describe la síntesis de análogos de hormonas esteroidales con estructuras conformacionalmente rígidas, debido a la presencia de un anillo adicional que incluye al carbono neopentílico de la posición 19 (metilo angular). Los esteroides sintetizados fueron 6,19-metanoprogesterona y 19(S)-metil-11,19-óxidoprogesterona. Las etapas clave para ambas síntesis fueron: i) funcionalización remota del metilo-19 realizada por medio de una reacción radicalaria desde un grupo hidroxilo ubicado en la posición 6β; ii) homologación de la posición neopentílica para generar un carbono adicional adecuadamente funcionalizado (C-19a); iii) formación del ciclo propiamente dicho. Para la etapa de homologación (reacción de Wittig) en la síntesis de 6,19-metanoprogesterona se desarrollaron condiciones libres de sales que permitieron la obtención de rendimientos excelentes, notablemente superiores a los descriptos para esa reacción en sustratos similares. Para la formación del puente 6,19-metano se utilizó una reacción de adición del doble enlace 5,6 sobre el carbono carbonílico incorporado en la etapa anterior (C-19a) catalizada por ácido de Lewis (reacción de Prins) la cual permitió realizar una ciclación 5-endo trig, no favorecida de acuerdo con las reglas de Baldwin. Se realizaron dos aproximaciones a la formación de puentes carbonados entre las posiciones 11 y 19. En la primera (vía iónica) se siguió la estrategia anterior utilizando como precursor para la ciclación 3β-acetiloxi-19-metilidén-5-pregnen-11,20-diona. Se obtuvo finalmente 19(S)- metil-11,19-óxidoprogesterona. En la segunda aproximación (vía radicalaria) se sintetizó el precursor 19-metilidén-3β-terbutildimetilsililoxi-11α-metiltiotiocarboniloxi-5- pregnen-20-ona y se intentó la ciclación por ataque del carbono radicálico generado en C- 11 sobre el carbono vinílico (C-19a) en diferentes condiciones experimentales (solvente, temperatura, concentración, transportados de radicales). Finalmente, se describen los ensayos biológicos realizados con 19(S)-metil-11,19-óxidoprogesterona (actividad mineralocorticoidea) y otros esteroides sintetizados durante este trabajo de tesis(actividad antiherpética). This thesis describes the synthesis of two analogues of steroidal hormones with conformationally rigid structures, owing to the presence of an additional ring that includes the neopentylic carbon at C-19 (angular methyl). The steroids synthesized were 6,19-methanoprogesterone and 19(S)-methyl-11,19-oxidoprogesterone. The key synthetic steps in both cases were: i. remote functionalization of the C-19 methyl from the 6β- hydroxyl group by means of a radical reaction; ii. homologation at the neopentylic position to generate an additional carbon adequately functionalized (C-19a); iii. Formation of the additional ring. The salt-free conditions developed for the homologation step (Wittig reaction) in the synthesis of 6,19-methanoprogesterone gave excellent yields, superior to those described in the literature with similar substrates. For the formation of the 6,19-methano bridge, the addition (catalyzed by a Lewis acid) of the 5,6-double bond onto the carbonylic carbon incorporated in the previous step (C-19a) was used. This reaction allowed a 5-endo trig ring closure, that is disfavored according to the Baldwin rules. Two approximations to the synthesis of 11,19-carbon bridged steroids were done. In the first one (ionic pathway) the same strategy described above was followed; 3β- acetyloxy-19-methylidene-5-pregnen-11,20-dione was used as starting material for the ring closure step. In this route, 19(S)-methyl-11,19-oxidoprogesterone was obtained. In the second approximation (radical pathway), 19-methylidene-3β-terbutyldimethylsilyloxy -11α-methyltiocarbonyloxy-5-pregnene-20-one was synthesized and the ring closure was attempted by attack of the radical carbon generated at C-11 onto the C-19a (vinyl) carbon in different conditions (solvent, temperature, concentration, and radical carrier). Finally, the biological test for 19(S)-methyl-11,19-oxidoprogesterone (mineralocorticoid activity) and other steroids synthesized in this thesis (antiherpetic activity) is described. Fil: Joselevich, María. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.