2,132 results on '"Periodontal tissue"'
Search Results
302. Amniotic Membrane In Palatal Epithelial-Connective Tissue Reconstruction
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Diletta Trojan, Giulia Montagner, Roberta Abate, and Mario Martelloni
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Periodontal tissue ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Scar tissue ,Connective tissue ,Mucogingival surgery ,General Medicine ,030204 cardiovascular system & hematology ,Tissue Graft ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Female patient ,030221 ophthalmology & optometry ,Medicine ,medicine.symptom ,business ,Gingival recession ,Reduction (orthopedic surgery) - Abstract
Mucogingival surgery has the objective to obtain coverage of the recession, with a favorable long-term prognosis, but also to minimize postoperative problems and surgery-related risks. Human amniotic membrane is increasingly employed for periodontal tissue repair in order to promote epithelialization and to reduce pain and scar tissue formation. A 38-year-old female patient reports dental hypersensitivity resulting from gingival recession affecting tooth 4.1. A mucogingival surgical procedure was proposed and a partial-thickness flap of epithelial-connective tissue was harvested from the palate and grafted on to the receiving site. The amniotic membrane was positioned at the donor site to reduce postoperative morbidity and to encourage rapid palatal healing. One week after the application of HAM (human amniotic membrane), the wound was healed and 1 month after the donor site was completely re-epithelialized. The present case report suggests that in the surgical treatment of gingival recession with palatal epithelial-connective tissue graft, HAM promotes rapid epithelialization of the palatal donor site wound with a reduction in morbidity.
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- 2019
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303. Bone grafting materials in dentoalveolar reconstruction: A comprehensive review
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George Agrogiannis, Theodore Karatzas, and S. Titsinides
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0301 basic medicine ,Periodontal tissue ,medicine.medical_treatment ,Dentistry ,Bone regeneration biomaterials ,Bone healing ,Bone grafting ,Article ,03 medical and health sciences ,0302 clinical medicine ,Tooth abscess ,Surgical removal ,medicine ,Bone regeneration ,General Dentistry ,Jaw bones ,Bone grafts ,business.industry ,030206 dentistry ,Bone defect ,medicine.disease ,lcsh:RK1-715 ,030104 developmental biology ,lcsh:Dentistry ,Distraction osteogenesis ,business ,Bone defects - Abstract
Summary: Bone deficits of the jaws are often attributed to accidents, surgical removal of benign lesions or malignant neoplasms, congenital abnormalities, periodontal inflammation, tooth abscess or extraction and finally jaw atrophy due to advanced age or general disease.These bone defects require rehabilitation for a variety of reasons, e.g. maintaining the normal anatomic outline, eliminating empty space, aesthetic restoration and placing dental implants. Today, several techniques have been developed to eliminate these bone deformities including bone grafting, guided bone regeneration, distraction osteogenesis, use of growth factors and stem cells.Bone grafts consist of materials of natural or synthetic origin, implanted into the bone defect site, documented to possess bone healing properties. Currently, a variety of bone restorative materials with different characteristics are available, possesing different properties.Despite years of effort the ‘perfect’ bone reconstruction material has not yet been developed, a further effort is required to make this objective feasible.The aim of this article is to provide a contemporary and comprehensive overview of the grafting materials that can be applied in dentoalveolar reconstruction, discussing their properties, advantages and disadvantages, enlightening the present and the future perspectives in the field of bone regeneration. Keywords: Bone defects, Bone grafts, Bone regeneration biomaterials, Jaw bones
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- 2019
304. Periodontal tissue regeneration after low‐intensity pulsed ultrasound stimulation with or without intra‐marrow perforation in two‐wall intra‐bony defects—A pilot study in dogs
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Takatomo Imafuji, Yoshinori Shirakata, Kotaro Sena, Kazuyuki Noguchi, Yukiya Shinohara, and Toshiaki Nakamura
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Periodontium ,Periodontal tissue ,Bone Regeneration ,business.industry ,Regeneration (biology) ,Perforation (oil well) ,Open flap debridement ,Pilot Projects ,Stimulation ,030206 dentistry ,Low-intensity pulsed ultrasound ,Beagle ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,medicine.anatomical_structure ,Ultrasonic Waves ,Bone Marrow ,Animals ,Periodontics ,Medicine ,030212 general & internal medicine ,Cementum ,business ,Nuclear medicine - Abstract
Aim To evaluate the effects of low-intensity pulsed ultrasound (LIPUS) with/without intra-marrow perforation (IMP) on periodontal healing in two-wall intra-bony defects in dogs. Materials and methods Two-wall intra-bony defects (5 mm wide, 5 mm deep) were created at the distal and mesial aspects of mandibular premolars in four beagle dogs (four defects per dog). The 16 defects were divided into four treatment groups: IMP, LIPUS, IMP + LIPUS (IMP/LIPUS) and control (open flap debridement). The LIPUS and IMP/LIPUS sites received daily LIPUS exposure for 3 weeks starting 1 week after surgery. The animals were euthanized 4 weeks after surgery for histologic evaluation. Results There was significantly greater new bone formation at LIPUS (2.93 ± 0.74 mm) and IMP/LIPUS (3.18 ± 0.52 mm) sites than at control sites (1.65 ± 0.46 mm). New bone area at LIPUS (6.36 ± 2.28 mm2 ) and IMP/LIPUS (6.13 ± 1.25 mm2 ) sites was significantly greater than that at control sites (2.15 ± 1.75 mm2 ). New cementum length at LIPUS sites (4.09 ± 0.75 mm) was significantly greater than that at control (2.29 ± 1.02 mm) and IMP (2.41 ± 0.41 mm) sites. No significant difference was observed between LIPUS and IMP/LIPUS sites in any histomorphometric parameter. Conclusions These findings suggest that LIPUS effectively promotes periodontal regeneration in two-wall intra-bony defects in dogs.
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- 2019
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305. Management of Class II furcation defects in dogs using combination of Propolis and Nanobone graft
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Rania A. Fahmy, Nesma M. Khalil, and Marwa M. Ibrahim
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Periodontal tissue ,business.industry ,Group ii ,Furcation defect ,Dentistry ,030206 dentistry ,Propolis ,03 medical and health sciences ,Honey Bees ,0302 clinical medicine ,medicine.anatomical_structure ,Buccal Surface ,030220 oncology & carcinogenesis ,Medicine ,Cementum ,business ,Bone surface - Abstract
Background: Periodontal regeneration using complementary and alternative medicine has gained considerable attention recently. Propolis is a resinous hive product collected by honey bees from exudates and buds of plants and mixed with wax and bee enzymes.Objective: The aim of this study was to evaluate the effect of propolis as bone graft substitute in the management of experimental grade II furcation defects, and to compare its effect to nanobone and to Propolis/nanobone mixture. Material and Methods: Sixteen critical-sized furcation defects on the buccal surface of mandibular third and fourth premolars were surgically created in twelve dogs and divided into three groups. Group I; defects were filled with Propolis, Group II; defects were filled with nanohydroxyapatite graft and Group III; defects were filled with a combination of Propolis/ nanohydroxyapatite graft. Histologically and histomorphometric analysis of newly formed interradicular bone height and percentage were performed after one and three months. Results: After one month; the three experimental groups revealed the features of early periodontal tissues regeneration including cementum, newly formed bone with inserted newly formed PDL fibers. The propolis group showed the highest bone height and bone surface area. After three months; denser bone occupying larger surface area of the furcation defect were noted especially in the propolis group. Conclusion: The addition of nanobone to propolis showed better results than nano bone alone especially at early healing stage. However, it didn’t show better results than the use of propolis alone.
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- 2019
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306. УЛЬТРАСТРУКТУРНА ОРГАНІЗАЦІЯ ПАРОДОНТА ПРИ ЧОТИРЬОХТИЖНЕВІЙ ДІЇ ОПІОЇДНОГО АНАЛЬГЕТИКА
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03 medical and health sciences ,Periodontal tissue ,0302 clinical medicine ,business.industry ,Medicine ,030212 general & internal medicine ,030206 dentistry ,General Medicine ,Periodontium ,Pharmacology ,Opioid analgesics ,business ,Electron microscopic - Abstract
This paper presents the results of an electron microscopic study of the cellular components of periodontal tissues with experimental exposure to opioids for 28 days. It has been established that degenerative-destructive changes in all structural components of the periodontium occur during the four-week action of the opioid analgesic. The researches carried out in the future can serve for the differential characterization of the destructive manifestations arising during the short and long-term action of opioid analgesics at the ultrastructural level.
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- 2019
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307. FEATURES OFT THE PERIODONTAL TISSUES ULTRASTRUCTURE UNDER CHRONIC PSYCHOEMOTIONAL STRESS
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O. V. Khrus
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03 medical and health sciences ,Periodontal tissue ,Pathology ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Ultrastructure ,Medicine ,030206 dentistry ,General Medicine ,business ,030217 neurology & neurosurgery - Abstract
With the help of electron microscopic and morphometric methods, the features of changes in the ultrastructure of periodontal tissues in persons with psychoemotional stresses were studied.It was shown that chronic psychoemotional stress is accompanied in the gum tissue by the development of endothelial and mitochondrial dysfunction with signs of edema and destruction of the capillary endothelium and a violation of the ultrastructure of about 50 % of the mitochondria in the cells.Structural changes were also observed in bone tissue. They testified about the development of destructive processes with the violation of intercellular signaling system and signs of necrotic cells. Such changes in the gum and bone tissues can promote the development of periodontitis in the case of chronic psychoemotional stress and lead to tooth loss.
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- 2019
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308. The origins of in vivo functional diagnosis of hemomicrocirculation in periodontal tissues in normal and pathological conditions in domestic dentistry
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A. K. Iordanishvili
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Periodontitis ,Periodontal tissue ,business.industry ,Dentistry ,Periodontology ,030204 cardiovascular system & hematology ,medicine.disease ,Clinical Practice ,03 medical and health sciences ,Gingivitis ,0302 clinical medicine ,In vivo ,Endocrine pathology ,medicine ,030212 general & internal medicine ,medicine.symptom ,business ,Pathological - Abstract
Purpose – to present the origins of in vivo functional diagnosis of hemomicrocirculation in periodontal tissues in normal and pathological conditions in domestic dentistry.Materials and methods: the material of the study was archival and reporting materials of research works of scientists-dentists, which deals with the functioning of periodontal tissues. These materials are used as a source of primary information. Analytical, medical and statistical research methods were used to study them.Results: information on the development and first application in dental practice of methods of in vivo microscopy and microphotography of gums with the clarity that allowed the use of these methods for many years, including modern dentistry. These methods were used for experimental studies in various animals (Guinea pigs, rabbits, cats, dogs) and in clinical practice, in norm and under various extreme effects of General and local character.Conclusion: the role of domestic scientists and dentists, in particular, the doctor of medical Sciences associate Professor M. K. Gacina, the development of functional methods of research of periodontal: of capillaroscopy and capillaroscopy. The importance of these methods of functional diagnosis of periodontal disease in clinical periodontics at the present stage, including periodontal disease in endocrine pathology, endodontal lesions and tissue pathology around dental implants.
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- 2019
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309. Emulsion electrospun PLA/calcium alginate nanofibers for periodontal tissue engineering
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Zhanchao Ye, Renze Shen, Weihong Xu, and Yurong Yan
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Periodontal tissue ,Calcium alginate ,Alginates ,Surface Properties ,Polyesters ,0206 medical engineering ,Nanofibers ,Biomedical Engineering ,Biocompatible Materials ,02 engineering and technology ,Bone tissue ,Bone and Bones ,Biomaterials ,chemistry.chemical_compound ,Tissue engineering ,Osteogenesis ,Elastic Modulus ,Cell Adhesion ,medicine ,Humans ,Cell Proliferation ,Bone Transplantation ,Tissue Engineering ,Tissue Scaffolds ,Chemistry ,Interleukins ,Regeneration (biology) ,Mesenchymal Stem Cells ,Nanofiber scaffold ,021001 nanoscience & nanotechnology ,020601 biomedical engineering ,Toll-Like Receptor 4 ,medicine.anatomical_structure ,Nanofiber ,Emulsion ,Emulsions ,0210 nano-technology ,Hydrophobic and Hydrophilic Interactions ,Biomedical engineering - Abstract
ObjectiveThe regeneration of periodontal bone tissue is a major obstacle in tissue engineering. We have recently designed a compound nanofiber scaffold for the tissue repair of periodontal bone, wh...
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- 2019
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310. SURVEY OF A FUNCTIONAL STATE OF MASSETER MUSCLES IN EDENTELOUS PATIENTS BASED ON THE DATA OF SURFACE ELECTROMYOGYOPHY STUDIES
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G.M. Balya, O.S. Shemetov, V.M. Dvornyk, V.S. Kuz, and G.M. Kuz
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Orthodontics ,Periodontal tissue ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Objective method ,Electromyography ,Prosthodontist ,«Vertex ThermoSens», thermoplastic dental materials, complete absence of teeth, electromyography ,Masticatory force ,lcsh:RK1-715 ,lcsh:Dentistry ,medicine ,Dentures ,Removable dentures ,business ,Fixation (histology) - Abstract
The difficulty of prosthetics and rehabilitation of patients with complete loss of teeth is associated with a burdened psychological and anatomical status. The main reasons for teeth extractions are periodontal tissue diseases, diseases of hard tooth tissues of carious and non-carious origin and traumas. Complete loss of teeth leads to a large number of local and general complications. The masticatory apparatus undergoes a number of functional and morphological changes. It becomes necessary to manufacture complete removable dentures to prevent the occurrence of pathologies in such situations. The effectiveness at this type of dentures depends on compliance with the protocols of their fabrication and the quality of the basic dental materials. Currently, prosthodontists use thermoplastic plastics in the fabrication of complete removable prostheses, more commonly the main group of materials for this constructions are heat-polymerized acrylic resins. Evaluation of the quality of the fabricated complete removable dentures and of the functional state of the masticatory system after prosthetics is determined by their fixation and stabilization, restoration of the patient's appearance and degree of masticatory effectiveness. It can be determined by using of a surface electromyography an objective method for evaluation of the functional state of muscles by recording of their electrical biopotentials. The aim of our study was to study the functional state of the masseter muscles using surface electromyography in edentulous patients, who got dentures made from a thermoplastic base material «Vertex ThermoSense» in the prosthodontics clinic. Material and methods. We used polyamide (nylon) «Vertex ThermoSense», (Netherlands) in this work, for the fabrication of complete removable dentures. We made dentures for 19 elderly and senile patients (60 years and older) with a complete absence of teeth, who retired to the prosthodontics clinic with a goal of manufacturing new complete removable dentures for the upper and lower jaws. Over the past 3-5 years, they have been using complete removable dentures that were made from acrylic resins. Results. Assessing the results of the electromyographic study after 1 year of using of the dentures, it can be concluded that the amplitudes during compression approach the norm and almost four times higher than before prosthetics. A similar pattern as observed with the arbitrary chewing: the amplitudes approach the norm in comparison with the results before prosthetics. As for the coefficient «K», its value decreased in comparison with the results before prosthetics almost twice, which is largely close to the norm. Conclusion. Based on our study of the functional state of the masticatory muscles using surface electromyography in edentelous patients, who got dentures made polyamide thermoplastic material from a «Vertex ThermoSens», we can conclude that of electromyographic studies before prosthetic treatment are significantly different from normal, and after a year of using of dentures are as close as possible to them, which indicates a quiche adaptation to dentures.
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- 2019
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311. Influence of vitamin D deficiency on progression of inflammation and reparative healing in patients with orofacial region diseases
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A. P. Grigoriants, A. A. Grigoriants, V. S. Nikitin, and I. N. Antonova
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Periodontal tissue ,medicine.medical_specialty ,business.industry ,vitamin d ,Inflammation ,General Medicine ,medicine.disease ,Gastroenterology ,vitamin D deficiency ,reparative healing ,dental implants ,Internal medicine ,hydroxycalciferrol ,periodontal inflammation ,Vitamin D and neurology ,Medicine ,Russian federation ,In patient ,medicine.symptom ,business - Abstract
Average group of patients in North-West region of Russian Federation has a Vitamin D deficiency condition. It is characterizes in decrease of straight and mediated effects of Vitamin D on various viscus systems. Authors put forward the thesis about specific mechanisms of inflammation and reparative healing in patients with Vitamin D deficiency and orofacial region diseases. Retrospective analyses of studies has been performed. Data has been ordered and presented in this article.
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- 2019
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312. ЕЛЕКТРОННОМІКРОСКОПІЧНІ ДОСЛІДЖЕННЯ ПАРОДОНТА ПРИ ДІЇ ОПІОЇДУ ВПРОДОВЖ ШЕСТИ ТИЖНІВ
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Pathology ,medicine.medical_specialty ,Periodontal tissue ,business.industry ,Mucous membrane ,Periodontium ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Opioid ,030202 anesthesiology ,medicine ,030212 general & internal medicine ,business ,Opioid analgesics ,medicine.drug - Abstract
The following work is aimed at studying the features of the restructuring of the structural components of periodontal tissues under the conditions of a six-week experimental effect of an opioid analgesic at the ultrastructural level. Destructive changes were found in all cellular components of the mucous membrane of the gums, the periodontium and in the links of the microcirculatory bed. The ultrastructural manifestations in periodontal tissues that occur with the action of an opioid analgesic for six weeks may serve as a morphological basis for further study of the dynamics of submicroscopic changes in the later stages of opioid exposure in the experiment.
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- 2019
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313. Periodontal Tissue Regeneration Using Trafermin in Periodontitis of Dogs
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Yoshiharu Nagahara and Kazuya Tamura
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Periodontitis ,Periodontal tissue ,business.industry ,Regeneration (biology) ,medicine ,Dentistry ,business ,medicine.disease - Published
- 2019
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314. IMPROVEMENT OF THE DIAGNOSIS OF PERIODONTAL TISSUES IN PATIENTS WITH DIFFERENT GINGIVAL BIOTYPE
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A. G. Nadtochiy, A. I Grudyanova, Anastasia Sergeevna Karpanova, O. I. Arsenina, and N. V. Popova
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stomatognathic diseases ,Periodontal tissue ,stomatognathic system ,business.industry ,General Engineering ,Gingival biotype ,Energy Engineering and Power Technology ,Dentistry ,Medicine ,In patient ,business - Abstract
The data of the ultrasonic gingiva thickness scanning are compared with the data obtained using the colorimetric probe system. We revealed that the white probe corresponds to the gingiva thickness - less than 0.5 mm; the green probe - the gingiva thickness from 0.6 to 0.9 mm; the blue probe - the gingiva thickness from 1.0 to 1.5 mm. If none of the probes is visible through the gingiva, such a biotype is regarded as very thick and its thickness reaches more than 1.6 mm. Thus, the colorimetric probe system can be used by a doctor for gingiva thickness examination the in the absence of an expensive ultrasound scanner.
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- 2019
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315. Comparison of mast cell counts between the patients with moderate and severe periodontitis
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Mehrnoosh Sadighi, Elham Karimifard, Shirin Fattahi, Masoume Faramarzi, and Amirali Mirzaie
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Periodontitis ,medicine.medical_specialty ,Periodontal tissue ,Periodontal surgery ,Toluidine blue staining ,business.industry ,toluidine blue staining ,moderate periodontitis ,medicine.disease ,Mast cell ,Severe periodontitis ,Gastroenterology ,severe periodontitis ,lcsh:RK1-715 ,medicine.anatomical_structure ,Internal medicine ,lcsh:Dentistry ,medicine ,Etiology ,Surgical treatment ,business ,mast cell - Abstract
Background. The role of mast cells in periodontal tissue degradation has been established. These cells can be efficient in the etiology of periodontitis by participating in gingival homeostasis and releasing cytokines and enzymes, resulting in connective tissue matrix breakdown. Therefore, the aim of this study was to compare the mast cell counts between patients with moderate and severe periodontitis. Methods. This case‒control study was performed on 15 subjects with severe periodontitis and 15 subjects with moderate periodontitis, who needed periodontal surgical treatment. Incisional biopsies were provided during periodontal surgery. Afterward, the mean counts of mast cells were determined after toluidine blue staining of the samples. Finally, data were analyzed with SPSS. Results. The results of this study showed that mast cell counts in severe periodontitis cases were lower than those in moderate periodontitis. However, there were no statistically significant differences between the two groups (P=0.611). In addition, the mean mast cell counts in males and females did not show a statistically significant difference (P=0.231), although the count was higher in female subjects. Conclusion. Based on the results, no statistically significant differences were found in mast cell counts between subjects with severe periodontitis and those with moderate periodontitis.
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- 2019
316. Periodontal Tissue Regeneration Using Brain-Derived Neurotrophic Factor Delivered by Collagen Sponge
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Camille Medina-Cintrón, Rodrigo Neiva, Adolfo Coelho de Oliveira Lopes, Edmara T.P. Bergamo, Paulo G. Coelho, Lukasz Witek, and Ilana Santos Ramalho
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Periodontium ,Periodontal tissue ,medicine.medical_specialty ,Bone Regeneration ,0206 medical engineering ,Biomedical Engineering ,Bioengineering ,02 engineering and technology ,Biochemistry ,Epithelium ,Biomaterials ,03 medical and health sciences ,Dogs ,Imaging, Three-Dimensional ,Neurotrophic factors ,Internal medicine ,medicine ,Animals ,Regeneration ,030304 developmental biology ,Dental Cementum ,Brain-derived neurotrophic factor ,0303 health sciences ,Chemistry ,Brain-Derived Neurotrophic Factor ,Regeneration (biology) ,X-Ray Microtomography ,020601 biomedical engineering ,Endocrinology ,Collagen sponge ,Female ,Collagen - Abstract
The various roles played by brain-derived neurotrophic factor (BDNF) in a multitude of tissues and at different scenarios have rendered BDNF a favorable candidate for improving tissue regeneration. Although the tested formulations of BDNF quantitatively regenerate tissue to a level similar to control groups, it resulted in significantly more instances of full regeneration.
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- 2019
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317. Clinical and histological reaction of periodontal tissues to subgingival resin composite restorations
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Emanuela Monari, Davide Zaffe, Sergio Spinato, A. Lucchi, Pierpaolo Cortellini, Luigi Generali, and Carlo Bertoldi
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Periodontium ,Deep margin ,Periodontal tissue ,Crowns ,business.industry ,medicine.medical_treatment ,Gingiva ,Dentistry ,Histology ,030206 dentistry ,Sulcus ,Composite Resins ,Periodontal probe ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Coronal plane ,medicine ,Humans ,Periodontal Index ,business ,General Dentistry ,Dental restoration - Abstract
To compare the clinical and histological response of supracrestal periodontal tissues to subgingival composite restorations versus natural root surfaces MATERIAL AND METHODS: In 29 subjects with a single tooth requiring subgingival restorations, a deep margin elevation (DME) procedure with composite resin was applied. Full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), and focal probing depth (PD) were measured at baseline, before DME, and after 3 months. The distance between the coronal marked (CM) point to the apical margin of the composite reconstruction (AMR), at baseline, and to the tip of the periodontal probe inserted to reach the bottom of the sulcus (APP), 3 months later, was measured. An all-around secondary flap, harvested to ensure the subsequent single-crown prosthetic rehabilitation was histologically processed. The histological inflammation degree was evaluated in areas of gingival tissues adjacent to the composite (group B) and adjacent to the natural surface of each single tooth (group A).Significant FMPS, FMBS, and PD decreases were observed (p 0.05). CM-AMR and CM-APP were significantly different (p 0.05), suggesting an attachment gain after 3-months. The inflammation level of gingival tissue was similar in groups A and B (p 0.05).For the first time, this topic was clinically and histologically studied in humans. Subgingival restorations resulted compatible with gingival health, with levels similar to that of untreated root surfaces.Deep margin elevation procedure produces favorable clinical and histological outcomes allowing a routine utilization in reconstructive dentistry.
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- 2019
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318. Photobiomodulation therapy in the treatment of periodontal disease: a literature review
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Asmaa Morsi, Norbert Gutknecht, Riman Nasher, and Fuad Alaijah
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Periodontal tissue ,Cell type ,medicine.anatomical_structure ,Periodontal disease ,business.industry ,medicine ,Osteoblast ,Bioinformatics ,business ,Fibroblast ,Original research - Abstract
Many studies in the literature address the effect of photobiomodulation therapy in the management of pathologies related to periodontal tissue. Due to the lack of standardized information and the absence of a consensus, this review presents the recent evidence on the effect of photobiomodulation (PBM) on proliferation of fibroblast cells and osteoblast cells in periodontal tissues. The literature and original research articles were used to investigate the effect of photobiomodulation therapy in periodontal diseases. Online MEDLINE/PubMed and Google scholar were used. Access dates were between 2010 and 2017. The research was confined to English-language literature. The literature search retrieved references on proliferation of fibroblast cells and osteoblast cells. Each topic is individually addressed in this review. In total, 13 14 relevant photobiomodulation articles were included in the review, comprising work completed on a variety of cell types and places. Although results consistently demonstrated the potential of laser irradiation to affect cellular proliferation in a wavelength- and dosage-dependent manner, the relevance of other key irradiation parameters, such as irradiance, to such effects remained unclear. The literature review showed several positive results of the PBM on proliferation of fibroblast cells and osteoblast cells in periodontal tissues.
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- 2019
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319. Effect of non-surgical periodontal therapy on serum and crevicular level of advanced glyacation end product in chronic periodontitis among a sample of the Egyptian population
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Olfat G. Shaker, Amira Maged, and Wesam Abdel Moneim
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Periodontitis ,medicine.medical_specialty ,Periodontal tissue ,education.field_of_study ,business.industry ,Population ,Proteolytic enzymes ,Inflammation ,medicine.disease ,medicine.disease_cause ,Chronic periodontitis ,Gastroenterology ,Internal medicine ,medicine ,Prognostic biomarker ,medicine.symptom ,business ,education ,Oxidative stress - Abstract
Background: AGEs are formed under oxidative conditions and are called advanced glyco-xidation end products. Periodontitis is a multifactorial inflammatory condition. The periodontal tissue damage is caused directly by bacteria and indirectly by inflammation and immunologic response against the bacteria. This inflammatory response is characterized by generation of prolonged release of neutrophil proteolytic enzymes, pro-inflammatory mediators and reactive oxygen species (ROS). Therefore, periodontitis is strictly linked to numerous pathologies which are related to production of oxidative stress and AGEs. Methods: The study was conducted on thirty participants, they were divided into two groups; group (A) which included fifteen medically free subjects, and group (B) which included fifteen patients suffering from periodontitis. Serum and GCF samples were collected for assessment of AGEs before and after non -surgical periodontal therapy. Data were analysed by SPSS. Results: Periodontitis group showed statistically significant higher mean AGE levels than control group in both serum and GCF samples. Moreover, there was a statistically significant decrease in AGE levels in both serum and GCF after treatment.Conclusion: Crevicular level of AGEs can be used as a non-invasive diagnostic and prognostic biomarker for periodontitis.
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- 2019
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320. The stability of different housekeeping genes in human periodontal ligament cells under inflammatory conditions
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Andreas Jäger, M. Setiawan, and Anna Konermann
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Normalization (statistics) ,Periodontal tissue ,Periodontal Ligament ,Centrifugation ,Biology ,Real-Time Polymerase Chain Reaction ,Culture Media, Serum-Free ,Genomic Instability ,Cell Line ,Andrology ,symbols.namesake ,Reference Values ,Humans ,Periodontal fiber ,Inflammation ,Genes, Essential ,Reproducibility of Results ,General Medicine ,Confidence interval ,Housekeeping gene ,Bonferroni correction ,YWHAZ ,symbols ,Analysis of variance ,Anatomy ,Developmental Biology - Abstract
Purpose Stability of housekeeping genes as internal reference for RT-qPCR analyses is mandatory for a correct interpretation of results. As no normalization benchmark exists and reference gene validation is highly specific for individual experiments, it was the purpose of this study to identify stable candidates for investigations on periodontal inflammation. Basic procedures Human PDL cells from one cell line (Lonza) and three primary donors were challenged with IL-1s (5 ng/ml) or centrifugation (170 × g) for 6 h under serum-free conditions. Unstimulated cells represented controls. qRT-PCR was performed with a TaqMan® array of 32 housekeeping genes (n = 3). Transcriptional stability was analyzed for (i) mean absolute CT values and (ii) relative fold changes. Finally, stability of mean CT values across specimens was evaluated for most stable candidates. Statistics were performed with one-way ANOVA and Bonferroni correction and one sample t-test, with 95% confidence level. Values represent mean ± SEM. Main findings 18S was constant in experimental groups and specimens for mean absolute CT values and relative fold changes, and MT-APT6 for mean absolute CT values. Both genes exhibited low CT thresholds ranging from 20.2 ± 0.1 to 25.9 ± 0.2 for 18S, and from 18.9 ± 0.0–23.7 ± 0.1 for MT-APT6. Likewise stable YWHAZ ranged between 32.6 ± 0.2 and 37.2 ± 0.2 cycles. However, candidates were unstable across specimes. Principal conclusions Reference validation is mandatory for RT-qPCR analyses in new experimental designs. Here, only three genes out of 32 turned out to be appropriate candidates. Due to low CT values and stability, 18S and MT-APT6 are most valid genes for data normalization in experiments with PDL cells under inflammatory conditions and are recommended as standards under these premises.
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- 2019
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321. Traction of an impacted maxillary canine with corticotomy in a 53-year-old patient: Case report
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Rúbia Maria Freitas dos Santos, Dauro Douglas Oliveira, Leena Palomo, Lara Karolina Guimarães, Bruno Franco de Oliveira, Laíze Rosa Pires Freitas, and Orlando Motohiro Tanaka
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Periodontitis ,Periodontal tissue ,Adult female ,business.industry ,medicine.medical_treatment ,Maxillary canine ,Dentistry ,Orthodontics ,030206 dentistry ,Traction (orthopedics) ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Clinical attachment loss ,Occlusion ,Medicine ,business ,030217 neurology & neurosurgery ,Corticotomy - Abstract
The viability of orthodontic traction of impacted teeth in adults is often questioned by a large percentage of orthodontists who would rather consider the extraction of these teeth. Although possible, orthodontic traction of impacted canines in adults takes longer than in younger patients, present a poorer prognosis that worsens with age. Because of the prevalence of periodontitis in adults versus children, periodontal inflammation must be identified and resolved in order to keep attachment loss from progressing during orthodontic care. Likewise mucogingival changes need to be predicted and managed. This article reports a successful case of impacted maxillary right canine traction in an adult female, associated with alveolar corticotomies and the use of skeletal anchorage. At the end of treatment, the canine was ideally positioned in the occlusion, presenting excellent esthetics, function, and healthy periodontal tissues.
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- 2019
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322. Influence of low-level laser (LLL) on interleukin 6 (IL-6) levels in gingival crevicular fluid (GCF) during orthodontic tooth movement of periodontally affected rabbits
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Ahmed Maher Fouda, Khalid S. Hassan, and Essam Abdelalim Nassar
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Male ,Periodontal tissue ,Tooth Movement Techniques ,Periodontal Ligament ,Dentistry ,Orthodontics ,Periodontal probe ,Crevicular fluid ,03 medical and health sciences ,0302 clinical medicine ,Animals ,Periodontal Pocket ,Periodontal fiber ,Medicine ,Maxillary central incisor ,030212 general & internal medicine ,Interleukin 6 ,biology ,Interleukin-6 ,business.industry ,Lasers ,Significant difference ,Gingival Crevicular Fluid ,030206 dentistry ,Incisor ,Tooth movement ,Models, Animal ,biology.protein ,Cytokines ,Rabbits ,business - Abstract
Summary Aim To evaluate the effects of LLL on IL-6 levels in the GCF and the Probing Pocket Depth measurements (PPD) during orthodontic tooth movement in periodontally affected rabbits. Methods Twenty-four rabbits were divided into 3 groups: Group 1(G1), healthy rabbits with orthodontic movement, Group 2(G2) periodontally affected rabbits and orthodontic movement, Group 3(G3) periodontally affected rabbits with orthodontic movement and LLL therapy. A 0.014 stainless steel spring was inserted in the upper central incisors to produce 60gm force. Laser CAT 500 was applied for 3 min/day for 2 weeks. PPD measurements were obtained at base line and after 14 days with electronic periodontal probe. Results IL-6 levels increased gradually after application of orthodontic force, afterwards the 8th day, a significant difference in the Il-6 levels between G1 vs. G2 and G2 vs. G3 was observed. PPD measurements showed significant difference between the three groups at base line and after 14 days. Clinical Significance LLL application can enhance periodontal ligament regeneration and decrease the periodontal tissue destruction through suppression of IL-6 levels.
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- 2019
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323. THE EFFECTIVENESS OF PREVENTION OF LOCALIZED INFLAMMATORY LESIONS OF PERIODONTAL TISSUES IN YOUNG PEOPLE WITH LOCAL RISK FACTORS FOR THE DEVELOPMENT OF DISEASES
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A.V. Kuznetsov, L.B. Filimonova, S.A. Romanov, and Ryazan Llc «Dental Clinic «Dentastil»
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Periodontal tissue ,business.industry ,Immunology ,Medicine ,business - Published
- 2019
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324. Classification of human gingival sulcus using swept-source optical coherence tomography: In vivo imaging
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Ruchire Eranga Wijesinghe, Mansik Jeon, Muhammad Faizan Shirazi, Jaeyul Lee, Jeehyun Kim, Hosung Jo, Jaeseok Park, and Pilun Kim
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Orthodontics ,Periodontal tissue ,genetic structures ,medicine.diagnostic_test ,business.industry ,Mandible ,Pixel intensity ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Optical coherence tomography ,Maxilla ,Medicine ,Maxillary central incisor ,Gingival sulcus ,business ,Preclinical imaging - Abstract
We demonstrated a preliminary research to investigate the feasible in vivo utilization of swept-source optical coherence tomography (SS-OCT) system with 1310 nm wavelength band to obtain morphological visualizations and human gingival sulcus depth measurements. Apart from the cross-sectional analysis, pixel intensity based OCT image classification algorithm is developed to identify the depth of gingival sulcus quantitatively. A total of 43 sites from the periodontal tissues of five healthy individuals were imaged in vivo by using the OCT system. Two periodontal tissues were right and left maxillary central incisors, while the other four periodontal tissues were left and right mandibular central incisors and later incisors. The developed classification algorithm could measure the gingival sulcus depths, which are 1.15 ± 0.21 mm of the maxilla and 1.06 ± 0.27 mm of the mandible. The averaged total depths obtained by the system was 1.10 ± 0.26 mm. Hence, the gingival sulcus depth could be quantitatively measured by using the swept-source OCT system with the developed image classification algorithm as well as revealing a structural visualization, which ultimately confirmed the potential applicability for gingival sulcus depth real-time assessment.
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- 2019
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325. Hierarchically Patterned Polydopamine-Containing Membranes for Periodontal Tissue Engineering
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Tara Aghaloo, Mohammad Mahdi Hasani-Sadrabadi, Nako Nakatsuka, Thomas D. Young, Sahar Ansari, Nika Taghdiri, Patricia Sarrion, Paul S. Weiss, Alireza Moshaverinia, Ali Khademhosseini, and Song Li
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Male ,Periodontium ,Periodontal tissue ,Bone Regeneration ,Indoles ,Polymers ,Polyesters ,Nanofibers ,Periodontal Membrane ,General Physics and Astronomy ,Biocompatible Materials ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Osteogenesis ,medicine ,Extracellular ,Animals ,Humans ,General Materials Science ,Cells, Cultured ,Cellular localization ,Periodontitis ,Tissue Engineering ,Tissue Scaffolds ,Chemistry ,Regeneration (biology) ,General Engineering ,Membranes, Artificial ,Mesenchymal Stem Cells ,021001 nanoscience & nanotechnology ,medicine.disease ,Rats ,0104 chemical sciences ,Cell biology ,Membrane ,Stem cell ,0210 nano-technology - Abstract
Periodontitis is a common chronic inflammatory disease that affects tooth-supporting tissues. We engineer a multifunctional periodontal membrane for the guided tissue regeneration of lost periodontal tissues. The major drawback of current periodontal membranes is the lack of tissue regeneration properties. Here, a series of nanofibrous membranes based on poly(ε-caprolactone) with tunable biochemical and biophysical properties were developed for periodontal tissue regeneration. The engineered membranes were surface coated using biomimetic polydopamine to promote the adhesion of therapeutic proteins and cells. We demonstrate successful cellular localization on the surface of the engineered membrane by morphological patterning. Polydopamine accelerates osteogenic differentiation of dental-derived stem cells by promoting hydroxyapatite mineralization. Such multiscale designs can mimic the complex extracellular environment of periodontal tissue and serve as functional tissue constructs for periodontal regeneration. In a periodontal defect model in rats, our engineered periodontal membrane successfully promoted the regeneration of periodontal tissue and bone repair. Altogether, our data demonstrate that our biomimetic membranes have potential as protein/cell delivery platforms for periodontal tissue engineering.
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- 2019
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326. Interaction of biologic therapy with apical periodontitis and periodontitis: a systematic review
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Davide Musu, Giampiero Rossi-Fedele, N Peddis, Elisabetta Cotti, and Francesca Ideo
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Periodontitis ,medicine.medical_specialty ,Periodontal tissue ,business.industry ,MEDLINE ,Scopus ,030206 dentistry ,medicine.disease ,Biological Therapy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,In patient ,030212 general & internal medicine ,Animal studies ,business ,General Dentistry ,Periapical Periodontitis - Abstract
Biologic medications (BMs) are increasingly used for the management of systemic chronic inflammatory diseases. These diseases are often associated with a higher prevalence of apical periodontitis (AP) and periodontitis (P). The purpose of this systematic review was to ascertain the interactions between AP and/or P and BMs. The review was registered in the PROSPERO database (CRD42017054756). Electronic searches were performed on Pubmed Medline, Scopus and The Web of Science from their inception through to 20 March 2018. The references of the articles selected were checked. The keywords were chosen based on a pilot search, which aimed to find the most frequently prescribed BMs. The included studies were appraised qualitatively using appropriate tools. Thirty-five articles met the inclusion criteria, comprising 16 non-randomized clinical studies, 12 in vivo animal studies and 7 case reports. Quality of information was assessed as high in 18 articles, moderate in 16 articles and low in 1 article. BMs in patients suffering from chronic inflammatory diseases seems to inhibit the progression of AP and P, and to enhance the healing response to periodontal and endodontic treatment. A healthier condition of the periodontal tissues seems to be associated with a better response of the patient to BMs therapy.
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327. Osteogenic cells transfer improving root coverage: A randomized clinical trial
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Maria Lúcia Rubo de Rezende, Ivania K C Arruda, Mariana Schützer Ragghianti Zangrando, Bruna Fidencio Rahal Ferraz, Carla Andreotti Damante, Sebastião Luiz Aguiar Greghi, Euloir Passanezi, Vitor de Toledo Stuani, and Adriana Campos Passanezi Sant'Ana
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0301 basic medicine ,Periodontal tissue ,Plaque index ,ENXERTO CONJUNTIVO ,Bleeding on probing ,Gingiva ,Dentistry ,Subepithelial connective tissue graft ,Surgical Flaps ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Humans ,Gingival Recession ,Tooth Root ,business.industry ,030206 dentistry ,Root coverage ,Alternative treatment ,Treatment Outcome ,030104 developmental biology ,Connective Tissue ,Periodontics ,medicine.symptom ,business ,Follow-Up Studies ,Efficacy Study - Abstract
Background and objective The aim of this interventional, parallel-assignment, single-blinded, randomized, efficacy study was to investigate the efficacy of the treatment of gingival recessions by osteogenic cell transfer. This is the first randomized clinical trial of this nature. Material and methods Treatment of Miller class I or II gingival recessions >4 mm was randomly defined by casual sorting and performed by newly forming bone graft (NFBG) and coronally advanced flap (CAF) or subepithelial connective tissue graft (SCTG) and CAF (control). Clinical examinations were performed by a single blinded examiner at baseline and at 3, 6, and 9 months after surgery. Parameters investigated were recession height (REC), probing depth (PD), clinical attachment level, gingival bleeding index (GBI), plaque index (PlI), and keratinized gingiva width (KGW). Results Both techniques achieved similar percentage of root coverage, but NFBG was more effective in pocket depth reduction, attachment level gain, and reduction of plaque accumulation and of bleeding on probing. Conclusions These findings suggest that the transfer of osteogenic cells by NFBG is able to improve clinical attachment level and to cover denuded roots. NFBG can be used as an alternative treatment of deep recessions (≥4 mm), where the restoration of lost periodontal tissues is intended.
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- 2019
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328. DYNAMICS OF PERIODONTAL TISSUES MICROBIOCENOSIS UNDER THE COMPLEX TREATMENT OF CATARRHAL GINGIVITIS AND CHRONIC GASTRODUODENITIS IN THE ADOLESCENTS
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M.M. Rozhko, I.S. Lisetska, and R. V. Kutsyk
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Periodontal tissue ,Pathology ,medicine.medical_specialty ,business.industry ,lcsh:R ,lcsh:Medicine ,chronic gastroduodenitis ,complex treatment ,Catarrhal gingivitis ,catarrhal gingivitis ,microbiocenosis ,Medicine ,adolescents ,business - Abstract
Background. The key links in the etiology and pathogenesis of periodontal tissue diseases are the quantitative and qualitative changes in the composition of the microflora of oral cavity, with the simultaneous deterioration of oral hygiene, reduction of local and general immunity, which occurs more often in the presence of somatic diseases. Objective. The aim of the research was to determine the clinical and microbiological efficacy of the developed treatment-prophylactic complex in the adolescents with catarrhal gingivitis and chronic gastroduodenitis before and after treatment. Methods. Changes were made to and before the treatment of clinical parameters, gingival microbiocenosis of 38 adolescents with generalized catarrhal gingivitis and chronic gastroduodenitis aged 12-18 years old, who comprised the main group. In the comparison group 25 adolescents of similar age diagnosed with generalized catarrhal gingivitis without any somatic diseases were involved. Results. It has been established that used combination (drug of plant origin with antimicrobial properties + dental gel with Metronidazole benzoate and Chlorhexidine digluconate + capsules of probiotics) yields the conventional treatment as well as exceeds it for examined clinical indicators and indexes. The treatment and prophylaxis with suggested complex have proved a significant positive effect on the gums microbiocenosis in adolescents with generalized catarrhal gingivitis and underlying concomitant gastroduodenitis. Conclusions. The suggested therapeutic and prophylactic complex provides a reduction in the massiveness and colonization frequency of the gum mucosa by pathogenic aerobic microflora (β-hemolytic streptococcus, golden staphylococcus, and yeast-like Candida fungi).
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329. Features of hard tooth and periodontal tissues among women with diabetes mellitus in various trimesters of pregnancy
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E. S. Silina, E. V. Grinenko, A. A. Aleksandrova, L. Yu. Orekhova, R. S. Musaeva, and E. S. Loboda
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Pregnancy ,Periodontal tissue ,medicine.medical_specialty ,genetic structures ,business.industry ,Obstetrics ,030206 dentistry ,medicine.disease ,behavioral disciplines and activities ,03 medical and health sciences ,0302 clinical medicine ,nervous system ,030220 oncology & carcinogenesis ,Diabetes mellitus ,medicine ,business ,psychological phenomena and processes - Abstract
Relevance of the research topic. There is a relationship between dental status of a pregnant woman and time of gestation. It is known that oral condition is changing depending on the trimester of pregnancy.Purpose. The aim of the research was to study and compare the clinical condition of oral cavity in this group of patients, depending on the gestation period.Methods and materials. For this purpose 110 pregnant women with diabetes mellitus were examined with using basic and additional examination methods.Results. Pregnant women in 2 gestation period have the worst condition of oral cavity.Summary. Analysis of results of the study allows us to determine the most critical phase during pregnancy and in future to promote normalization of oral cavity precisely in this period.
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330. A gyógyszer által indukált állcsontnecrosis-kockázat mértékének meghatározása az általános fogorvosi gyakorlatban
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Zsuzsanna Tóth, Anna Zurányi, and Enikő Szabó
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medicine.medical_specialty ,Periodontal tissue ,business.industry ,Anatomical structures ,General Medicine ,Disease ,medicine.disease ,Treatment plan ,Internal medicine ,Concomitant ,medicine ,Etiology ,Osteonecrosis of the jaw ,business ,Adverse effect - Abstract
Abstract: Medication-related osteonecrosis of the jaw may appear as adverse effect in antiresorptive therapy. Its successful treatment is challenging. We aimed to gather the systemic and local factors playing a role in etiology, published after its recognition. Risk factors were collected from the PubMed database 1998–2018. The three main groups of risk patients are: patients starting, patients having antiresorptive therapy, osteonecrosis diagnosed patients. The dentist must recognize risk factors, determine appropriate treatment plan and frequency of check-ups. Oncological disease treated intravenously means the greatest risk. Further systemic risk factors are: supportive therapies, concomitant disease, way of life, individual factors. Local risk factors may be: dentoalveolar surgery, periapical and periodontal inflammation, ill-fitting denture, presence of some anatomical structures. The accumulation of risk factors determines the probability of the manifestation of osteonecrosis. The most favorable case is patient starting antiresorptive therapy with a dental status needing no treatment. Orv hetil. 2019; 160(7): 243–251.
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331. Role of AP-1 transcriptional factor in development of oxidative and nitrosative stress in periodontal tissues during systemic inflammatory response
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A. M. Yelins’ka, O. Ye. Akimov, and V. O. Kostenko
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Periodontal tissue ,Transcriptional factor ,Chemistry ,Inflammatory response ,Oxidative phosphorylation ,superoxide-anion-radical ,systemic inflammatory response ,activator protein 1 (AP-1) ,Biochemistry ,Cell biology ,lcsh:Biochemistry ,nitric oxide cycle ,lcsh:QD415-436 ,periodontium - Abstract
Chronic systemic inflammatory response syndrome (SIRS) underlies many diseases (sepsis, atherosclerosis, diabetes mellitus). According to research data of recent years the key role in the development of SIRS is played by the activation of various nuclear transcription factors. The work was aimed at studying the role of such transcription factor as activator protein 1 (AP-1) in the development of oxidative and nitrosative stress in soft periodontal tissues during chronic systemic inflammatory response (SIRS). The experiment was carried out on 24 the Wistar rats. We induced SIRS by bacterial lipopolysaccharide of Salmonella typhi (0.4 μg/kg) intraperitoneal injection. We studied changes in the functioning of the nitric oxide (NO) cycle, the production of superoxide anion radical (O2•-) and the activity of antioxidant enzymes in soft periodontal tissues homogenate. We used SR11302 as an Ap-1 inhibitor (15 mg/kg) for 2 months. We established that during the SIRS modeling, the activity of antioxidant enzymes in soft periodontal tissues decreased with a simultaneous increase in the production of O2•-. SIRS elevated the production of NO by inducible NO-synthase (iNOS) and nitrite reductases. The nonoxidative cleavage of L-arginine under this condition was also increased. The concentration of peroxynitrite (ONOO–) was shown to be elevated more than 2-fold. The inhibition of AP-1 by SR11302 normalized the functional state of the NO cycle, reduced O2•- production and restored the activity of antioxidant enzymes. In this way, under SIRS conditions, “vicious circle” of ONOO– formation is formed. SIRS in soft periodontal tissues poses a threat of oxidative and nitrosative stress development. Usage of AP-1 activation inhibitor SR11302 breaks “vicious circle” of ONOO– formation.
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- 2019
332. EFFICACY OF PLATELET RICH FIBRIN IN COMBINATION WITH ENAMEL MATRIX DERIVATIVE ON PERIODONTAL TISSUES REGENERATION IN RATS
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Fatma MIbrahim, Jilan MYoussef, Islam Ateia, Menatalla MElhindawy, and Noraddin RAlmaqtari
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Periodontal tissue ,stomatognathic system ,Chemistry ,International Journal of Advanced Research (IJAR) ,Regeneration (biology) ,Enamel matrix derivative ,Platelet-rich fibrin ,Cell biology - Abstract
Objectives: Evaluating the efficacy of enamel matrix derivative in combination with platelet rich fibrin on periodontal tissues regeneration in rats. Material and methods: This experimental trail that was conducted on twenty-four adult healthy male Wistsrrats, animals were housed in separated cages as two rats per cage. Rats were kept in suitable conditions like temperature, humidity, standard food for rodents. Animals randomly allocated into 3 groups (8 rats each); G1: control group, left to heal without intervention, G2: treated by enamel matrix derivatives (EMD), G3: treated by enamel matrix derivatives plus platelet rich fibrin (EMD+PRF). Induced periodontal fenestration defects were created at buccal side of the distal root of the 1st mandibular molar and the mesial root of the 2ed mandibular molar. After surgery rats housed in a clean sterile cage and received special care. After induction of the fenestration defect by one month, four rats from each group were sacrificed. While, the remaining four rats of each group were sacrificed after another one month. Results: Histological analysis showed that periodontal tissues had best regeneration of periodontal fibers with more mature bone formation in the EMD+PRF group (G3) comparing to other groups. In addition, other groups showed favorable regeneration of periodontal tissues. Conclusions: Application platelet rich fibrin in combination with biological mediators such as enamel matrix protein in periodontal treatment improves regeneration of periodontal tissues.
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- 2019
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333. Nuclear morphological changes in gingival epithelial cells of patients with periodontitis
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Daniel Jerković, Marija Roguljić, Antonija Tadin, Davor Zeljezic, and Lidia Gavić
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Male ,Periodontal tissue ,Karyolysis ,Pathology ,medicine.medical_specialty ,DNA damage ,Gingiva ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Periodontitis ,General Dentistry ,Cell Nucleus ,Micronucleus Tests ,business.industry ,Epithelial Cells ,030206 dentistry ,medicine.disease ,Chromatin ,Micronucleus test ,Periodontal diseases ,030220 oncology & carcinogenesis ,Biomarker (medicine) ,Female ,business ,After treatment ,DNA Damage - Abstract
Objectives: This study assessed the frequency of nuclear morphological changes in gingival epithelial cells, as a biomarker for DNA damage, in individuals with periodontitis, before and after implementation of periodontal therapy, and compared the morphology to those with healthy periodontal tissues. Materials and methods: Exfoliated gingival cells were taken from 30 participants without periodontal destruction in any teeth and 30 participants with periodontitis before and after 45 and 90 days following treatment. Nuclear morphological changes were analyzed using the micronucleus test. Results: Compared with the healthy volunteers, those with periodontitis had a significant increase in the number of cells with nuclear broken eggs (P = 0.048), condensed chromatin (P = 0.015), karyolysis (P < 0.001), or binuclei (P < 0.001). In the periodontitis group, the pretreatment frequencies of cells with micronuclei (P = 0.008), binuclei (P < 0.001), karyolysis (P = 0.038), nuclear buds (P = 0.005), and condensed chromatin (P = 0.015) were significantly higher than 90 days after treatment. Conclusion: Our observations suggest that periodontal disease increases the frequency of nuclear morphological changes in gingival epithelial cells and that the implementation of periodontal therapy was associated with a reduction of that number. Clinical relevance: The micronucleus test could serve as a tool for estimating genotoxic damage in assessing the success of periodontal therapy
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334. The condition of periodontal tissues on the background of chronic cholecystitis and therapeutic measures
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Ya.A. Samedli
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medicine.medical_specialty ,Periodontal tissue ,business.industry ,Chronic cholecystitis ,Internal medicine ,medicine ,business ,Gastroenterology - Published
- 2019
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335. Identifying Candida albicans of inflammatory periodontal diseases
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Protein profiling ,Periodontal tissue ,biology ,Chemistry ,Candida albicans ,biology.organism_classification ,Microbiology - Abstract
Using of modern methods of microbiological diagnostics allows determining the sensitivity of Candida albicans fungi and identifying them, including using the direct protein profiling method MALDI-TOF mass spectrometry, and prescribed antimycotic drugs should be part of the modern complex treatment of inflammatory periodontal diseases, which will stabilize the microbiocenosis and reduce inflammatory phenomena in periodontal tissues.
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- 2019
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336. Importance of interim restorations in the molar region
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Toshio Maseki, Jun Takebe, Yoichiro Nara, Masanori Fujisawa, Takumi Ogawa, Shoko Miura, and Futoshi Komine
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Molar ,Periodontal tissue ,business.industry ,medicine.medical_treatment ,Dentistry ,030206 dentistry ,Prosthesis ,Prosthetic treatment ,Dental Restoration, Temporary ,03 medical and health sciences ,0302 clinical medicine ,Stomatognathic system ,Temporary crown ,Interim ,Medicine ,business ,General Dentistry ,Abutment (dentistry) ,030217 neurology & neurosurgery - Abstract
Interim restoration protects abutment teeth and periodontal tissues until prosthetic treatment ends with the fabrication of a definitive prosthesis, restores and maintains the functions and morphology of the stomatognathic system, and preserves the occlusal contact relationship. Temporary prostheses are used for a short time, to confirm the diagnosis and treatment plan. However, because interim restorations are used only briefly, their importance in ensuring the success of definitive prostheses is often overlooked. This review includes a comprehensive literature review of interim restoration of molars and summarizes the current clinical understanding and status of this functionally important area. Peer-reviewed publications were identified by searching PubMed in November 2018. An interim restoration, even when used briefly, can help dentists evaluate many aspects of the treatment plan and contribute to accurate prognosis of prosthetic treatment.
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- 2019
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337. The role of Platelet-rich fibrin (PRF) in Periodontology
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Burhan Nezar Hamdi, Zaid Yosef Almotawa, Shahad Mohammed Halawani, Maram Abdullah Al-Henaky, and Sahar Amer Al-Harbi
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Periodontal tissue ,biology ,business.industry ,Regeneration (biology) ,Dentistry ,Connective tissue ,Periodontology ,Fibrin ,Platelet-rich fibrin ,medicine.anatomical_structure ,Periodontal disease ,biology.protein ,Medicine ,business ,Wound healing - Abstract
Periodontal disease is characterized by the loss of attached connective tissue and other periodontal tissues. Growth factors secreted from platelets promote tissue formation and wound healing. Platelet-rich fibrin (PRF) is composed of fibrin, platelets leukocytes and other cells that have a great role in different wounds healing processes. The aim of the current review was to highlight the role and mechanism of PRF usage in periodontal regeneration for periodontally affected teeth. A systematic search was made using an online database Medline to locate relevant peer-reviewed articles and textbooks published between 1990 to 2017 in English. Specific search keywords were used to obtain all possible articles concerned with the subject. We found 25 articles meeting our criteria and 20 of them were specifically related to the subject were selected for final analysis. Few studies have focused on the role of PRF in periodontology especially for periodontal regeneration and most of them were trials. PRF is considered a simple and inexpensive way for successful periodontal regeneration.
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- 2019
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338. The interaction between the pulp and periodontium
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M.B. Prijampolskaja and E.V. Kozolij
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Periodontal tissue ,business.industry ,Dentistry ,Pulp (tooth) ,Medicine ,Periodontium ,business ,Complex problems ,Marginal periodontitis - Abstract
The article considers the phenomenon of functional and anatomical unity of pulp and periodontal tissues. The complex problems arising at presence of various sources of infection are covered. The characteristic features of combined manifestation and course of diseases of apical and marginal periodontitis are described. The historical review of the literature on this subject, the essence of modern concepts of diagnostics and treatment of endoperiolesion is given.
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339. The Role of Low-Level Sodium Fluoride in Periodontal Inflammation
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Hirohisa Arakawa, Il-Shin Kim, and Wenqun Song
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Periodontal tissue ,medicine.medical_specialty ,Chemistry ,Medicine (miscellaneous) ,Cell Biology ,Biochemistry ,Biomaterials ,chemistry.chemical_compound ,Endocrinology ,Internal medicine ,Sodium fluoride ,medicine ,Orthopedics and Sports Medicine ,General Dentistry - Published
- 2019
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340. THE EFFECT OF LOW FREQUENCY ELECTROMAGNETIC RADIATION ON THE MORPHOLOGY OF DENTAL AND PERIODONTAL TISSUES (EXPERIMENTAL INVESTIGATION)
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Iryna V Markovskaya
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Periodontal tissue ,Risk groups ,business.industry ,Medicine ,Dentistry ,General Medicine ,business ,Electromagnetic radiation ,Histochemical staining - Abstract
Objective Introduction: Low intensity electromagnetic effects possess a high biological activity, reduce the adaptive reserves of the body, impair immunity, adversely affect the functional state of the organs and body systems. The aim of the study was to identify in the experiment the effect of low-frequency electromagnetic radiation on the morphological state of the dental and periodontal tissue. Patients and methods Materials and methods: The experiment was conducted on WAG rats weighing 180-200 g, during which two groups were formed: group 1 (control group) included 12 WAG rats, which were not performed any manipulations; the rats of group 2 (investigation group) (n=12) for 30 days were exposed to a 70 kHz low-frequency alternating electric field (5th frequency range) daily from 9.00 to 12.00. To simulate a low-frequency 70 kHz alternating electric field, certified experimental equipment was used. The study material was the upper jaw tissue. Histological and histochemical staining methods were used. Morphometric study was conducted. Results Results: Complex morphological study on the experimental material allowed identifying the damaging effect of low-frequency electromagnetic radiation on the structural components of tooth and periodontal tissues. Conclusion Conclusions: Our findings suggest that the workers who are exposed to occupational low-frequency electromagnetic radiation should be included in the risk group for developing diseases of the dentomandibular system in order to carry out timely therapeutic and preventive measures.
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341. Assessment of the Efficacy of Periodontal Tissue Regeneration using Non-resorbable and Bioabsorbable GTR Membrane—A Clinical Comparative Study
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Rajanna Kv Patel, Sultan A Almalki, Roshan Rajan Varkey, Rincy Roshan, Mohammad Jalaluddin, and Preethi Nagdev
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Adult ,Male ,Periodontal tissue ,Plaque index ,Group ii ,Dentistry ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Scaling and root planing ,Absorbable Implants ,Periodontal Attachment Loss ,Humans ,Periodontal Pocket ,Medicine ,General Dentistry ,business.industry ,Furcation Defects ,Regeneration (biology) ,Significant difference ,Furcation defect ,Membranes, Artificial ,030206 dentistry ,Middle Aged ,medicine.disease ,Chronic periodontitis ,Treatment Outcome ,030220 oncology & carcinogenesis ,Guided Tissue Regeneration, Periodontal ,Female ,business ,Follow-Up Studies - Abstract
Aim The present study aims to assess the efficacy of non-resorbable and bioabsorbable guided tissue regeneration (GTR) membrane periodontal tissue regenerative methods. Materials and methods Thirty teeth taken from 20 patients (8 males and 12 females) within the age range of 20-55 years having chronic periodontitis were enrolled in this trial. All the enrolled patients underwent phase I therapy which included scaling and root planing performed in two sittings by a single practitioner. Patients who fulfilled the selection criteria entered the study and were randomly allocated to the three groups. Group I: control group, group II: patients who received a non-resorbable GTR membrane, and group III: patients who received a bioabsorbable GTR membrane. The clinical parameters that were documented at baseline, 3 months, and 6 months postoperatively were the gingival index, plaque index, and probing depth (vertical and horizontal) for all the three groups. Results The mean gingival index score was 1.64 ± 0.32 in group III at baseline, which decreased to 1.20 ± 0.10 at 6 months postoperatively. The plaque index reduced from 1.36 ± 0.46 at baseline to 1.04 ± 0.01 at 6 months postoperatively. The vertical and horizontal probing depths demonstrated a statistically significant difference between all the three groups. Conclusion The present study established that both membranes resulted in clinically and statistically significant improvements in the treatment of grade II furcation defects.
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342. Coronally Repositioned Flap with Bioresorbable Collagen Membrane for Miller’s Class I and II Recession Defects: A Case Series
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Mrinalini Agarwal and Deepa Dhruvakumar
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Periodontal tissue ,Root surface ,genetic structures ,business.industry ,Short Communication ,medicine.medical_treatment ,Collagen membrane ,Dentistry ,General Medicine ,Root coverage ,eye diseases ,Anterior region ,medicine ,sense organs ,medicine.symptom ,business ,human activities ,Gingival recession ,Type I collagen ,Reduction (orthopedic surgery) - Abstract
Objective: Gingival recession is one of the most common esthetic and functional concerns associated with periodontal tissues. Several techniques have been described to cover the exposed root surface. The aim of the present study was to evaluate the efficacy of recession coverage using a coronally repositioned flap in conjunction with a bioresorbable collagen membrane. Methods: Eight non-smoking healthy subjects with Miller’s Class I and II recession defects in the maxillary anterior region were selected. Recession was treated by a coronally repositioned flap along with a bioresorbable type I collagen guided tissue regeneration membrane (Periocol®). Clinical parameters recorded were recession depth, recession width, width of keratinized tissue, and width of the attached gingiva at baseline and 3 months postoperatively. Results: Three-month postoperative measurements demonstrated significant root coverage and a reduction in the recession depth and width. In addition, there was a significant increase in the width of keratinized tissue and of the attached gingiva. Conclusion: Recession coverage with a coronally repositioned and bioresorbable collagen membrane demonstrated good results in terms of root coverage as well as increase in the width of keratinized tissue.
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343. PERIODONTAL DISEASES AND ATHEROSCLEROSIS (LITERATURE REVIEW)
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Orysia O Bandrivska, Iryna S Dankevych-Kharchyshyn, Yurij L Bandrivsky, Roman M Gnid, Oleg I Mrochko, Olena Mykolayivna Vynogradova, Lidiya Y Minko, Natalia V Malko, and Andriana P Skalat
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medicine.medical_specialty ,Periodontal tissue ,business.industry ,030206 dentistry ,General Medicine ,030204 cardiovascular system & hematology ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Periodontal disease ,medicine ,Etiology ,Risk factor ,Intensive care medicine ,business ,ATHEROSCLEROTIC VASCULAR DISEASE - Abstract
Objective Introduction: The relationship between periodontal diseases and atherosclerosis is addressed in this article. Both these diseases have an inflammatory basis. Because periodontal disease is a risk factor for developing atherosclerotic vascular disease, diagnosis of the former is important. Particular attention must be paid to patients who have periodontal disease with other risk factors for atherosclerotic vascular disease. Recommendations managing these patients have been made included. The aim: The paper is aimed at familiarization of broad medical public with the presence of the relationship between diseases of periodontal tissues and atherosclerosis. Patients and methods Materials and methods: A thorough comprehensive analysis and generalization of scientific achievements elucidated in the fundamental and periodical publications, relating to diseases of the periodontal tissues and atherosclerosis, has been carried out. Results Review: The article consists of many researchers regarding the prevalence and intensity of periodontal tissue diseases in people of all ages. Problems associated with the state of periodontal tissues in people under study as dentists and general practitioners. Proven role in the pathogenesis of inflammatory diseases of the periodontal tissues in people with atherosclerosis. In the modern concept of the etiology and pathogenesis of periodontal diseases in people is extremely important role for the immune system and resistance to periodontal bacterial invasion. Analyzed common changes important for pathogenesis of periodontal tissue diseases and atherosclerosis. Conclusion Conclusions: Consequently, recent studies have shown a clear, directly proportional relationship between periodontal tissue diseases and atherosclerosis, but mechanisms for their development and interaction are not fully disclosed.
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- 2019
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344. Automatic Segmentation of Periodontal Tissue Ultrasound Images with Artificial Intelligence: A Novel Method for Improving Dataset Quality
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Radu Chifor, Mircea Hotoleanu, Tiberiu Marita, Tudor Arsenescu, Mihai Adrian Socaciu, Iulia Clara Badea, and Ioana Chifor
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Artificial Intelligence ,Image Processing, Computer-Assisted ,Humans ,Neural Networks, Computer ,Electrical and Electronic Engineering ,Biochemistry ,Instrumentation ,Algorithms ,Atomic and Molecular Physics, and Optics ,periodontal tissue ,automatic segmentation ,artificial intelligence ,dataset quality ,3D ultrasound reconstructions ,Ultrasonography ,Analytical Chemistry - Abstract
This research aimed to evaluate Mask R-CNN and U-Net convolutional neural network models for pixel-level classification in order to perform the automatic segmentation of bi-dimensional images of US dental arches, identifying anatomical elements required for periodontal diagnosis. A secondary aim was to evaluate the efficiency of a correction method of the ground truth masks segmented by an operator, for improving the quality of the datasets used for training the neural network models, by 3D ultrasound reconstructions of the examined periodontal tissue. Methods: Ultrasound periodontal investigations were performed for 52 teeth of 11 patients using a 3D ultrasound scanner prototype. The original ultrasound images were segmented by a low experienced operator using region growing-based segmentation algorithms. Three-dimensional ultrasound reconstructions were used for the quality check and correction of the segmentation. Mask R-CNN and U-NET were trained and used for prediction of periodontal tissue’s elements identification. Results: The average Intersection over Union ranged between 10% for the periodontal pocket and 75.6% for gingiva. Even though the original dataset contained 3417 images from 11 patients, and the corrected dataset only 2135 images from 5 patients, the prediction’s accuracy is significantly better for the models trained with the corrected dataset. Conclusions: The proposed quality check and correction method by evaluating in the 3D space the operator’s ground truth segmentation had a positive impact on the quality of the datasets demonstrated through higher IoU after retraining the models using the corrected dataset.
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- 2022
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345. Periodontal condition of mandibular incisors treated with modified Kazanjian vestibuloplasty compared to untreated sites: A prospective study
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Renata Górska, Małgorzata Nędzi-Góra, Bartłomiej Górski, Beata Wyrębek, Paweł Plakwicz, and Katarzyna Gawron
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Periodontal tissue ,Test group ,Gingiva ,Medicine (miscellaneous) ,Dentistry ,General Biochemistry, Genetics and Molecular Biology ,Gingivitis ,Internal Medicine ,Medicine ,Humans ,Pharmacology (medical) ,Gingival Recession ,Prospective Studies ,Vestibuloplasty ,Prospective cohort study ,Gingival recession ,Genetics (clinical) ,business.industry ,Soft tissue ,Incisor ,Treatment Outcome ,Connective Tissue ,Reviews and References (medical) ,medicine.symptom ,business ,Gingival margin ,Follow-Up Studies - Abstract
Background A shallow vestibule, insufficient keratinized tissue width and pulling of marginal gingiva may be associated with gingival recession, plaque accumulation and gingivitis. Conventional techniques for treatment of gingival recession use autogenous or allogenic grafts. However, these methods result in soreness at the donor site and pose an economic burden, which may cause patients to withdraw from treatment. Alternative therapy is currently not available to treat such patients. Objectives The aim of this study was to evaluate changes in periodontal tissue at the mandibular incisors after vestibuloplasty, focusing on functional improvement of the existing soft tissue with no grafting. Material and methods Thirty patients with a shallow vestibule, minimal keratinized tissue width (KTW; ≤1 mm), gingival recession (REC) and pulling of gingiva underwent modified Kazanjian vestibuloplasty were included into the test group, whereas 27 patients did not undergo any surgery (control group). The probing pocket depth (PPD), clinical attachment level (CAL), gingival recession depth (GRD), and KTW were assessed at baseline and 12 months post-surgery. Results The mean KTW, GRD and CAL values improved in the test group. A significant increase in mean KTW value (1.17 ±1.22 mm, p = 0.0406) was detected in the test group, while the control group showed a further reduction in mean KTW value (0.13 ±0.45 mm). The mean GRD value decreased from 2.09 ±1.78 mm to 1.22 ±1.46 mm (p = 0.0087) in the test group, whereas in controls the mean GRD value increased from 1.95 ±1.29 mm to 2.34 ±1.44 mm (p = 0.0164). The mean KTW value at 3, 6 and 12 months compared to baseline showed an increase in the test group, and the mean GRD and CAL values exhibited the potential to improve. Conclusions Sites treated with vestibuloplasty showed increased KTW, improvement in the gingival margin and CAL gain, whereas untreated sites showed continuous deterioration of the evaluated parameters. Vestibuloplasty may be recommended for patients avoiding major surgery for which functional improvement in tissue alone would provide a sufficient therapeutic outcome.
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- 2021
346. Expression of Wnt10b, β-catenin, Rankl and Runx2 in the Periodontal Tissues During Orthodontic Tooth Movement in Rats
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Yi Li, Kaixin Ji, Miaomiao Zhang, Man Zhang, SiYan Chen, Yanyun Zhang, He Wang, and Minjie Zhang
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RUNX2 ,Periodontal tissue ,biology ,business.industry ,RANKL ,Catenin ,Tooth movement ,biology.protein ,Cancer research ,Medicine ,business - Abstract
Objectiveto investigate the expression of Wnt10b, Rankl, β-catenin and Runx2 mRNA in periodontal tissues during orthodontic tooth movement (OTM) in rats; Materials and methods36 healthy male SD rats were selected and divided into six groups randomly according to the time of the force applied (0 hour, 12 hours, 24 hours, 5 days, 7 days, 14 days), with 6 rats in each group. 0hour group served as the control group. Except for control group, an orthodontic force of 50g was applied to the upper-left first molar with a nickel-titanium tension spring. The expression of Wnt10b, Rankl, β-catenin and Runx2 during OTM were detected by Real-time PCR (RT-PCR). ResultsCompared with the control group, Wnt10b mRNA expression in the pressure side was inhibited at the initial stage, and then increased, reached peak at day 5. A strong expression of Rankl mRNA in the pressure side can be seen from 12 hours to 14 days. The expression level was consistently higher than control group, and it peaked at day 7. The initial expression of β-catenin and Runx2 mRNA in the periodontal tissues of the experimental groups were small in the tension side, but still higher than the control group. The expression increased gradually with the extension of time, and reached the peak at day 7 after force treatment. ConclusionWnt10b, β-catenin, Rankl and Runx2 are related to periodontal tissues remodeling during OTM in rats; Wnt10b/β-catenin signaling pathways participate in periodontal tissue remodeling during OTM.
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- 2021
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347. Influence of Intermittent Parathyroid Hormone (PTH) Administration on the Outcomes of Orthodontic Tooth Movement—A Systematic Review
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Faris Yahya Asiri and Zohaib Khurshid
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0301 basic medicine ,Periodontal tissue ,Technology ,QH301-705.5 ,QC1-999 ,MEDLINE ,Parathyroid hormone ,Dentistry ,03 medical and health sciences ,0302 clinical medicine ,systematic review ,Medicine ,parathyroid hormone ,General Materials Science ,Favorable outcome ,Biology (General) ,Instrumentation ,QD1-999 ,Fluid Flow and Transfer Processes ,business.industry ,Process Chemistry and Technology ,Physics ,General Engineering ,030206 dentistry ,Engineering (General). Civil engineering (General) ,Computer Science Applications ,orthodontic tooth movement ,Chemistry ,030104 developmental biology ,Tooth movement ,Animal studies ,TA1-2040 ,business - Abstract
Objective: The aim of this review is to summarize the effects of local and systemic PTH administration on periodontal tissues during orthodontic tooth movement. Materials and methods: An electronic search was conducted on the following databases: PubMed/MEDLINE, Google Scholar, SCOPUS and Embase. On PubMed/MEDLINE, the Medical Subject Headings (MeSH) keywords used were: “orthodontic tooth movement” OR (“tooth” (All Fields) AND “tooth movement” (All Fields)) OR “tooth movement” (All Fields)) AND (“parathyroid hormone”); all studies included using CONSORT. Results: After elimination of duplicates and articles not meeting our inclusion criteria, seven animal studies were included in this review. Although the majority of the studies suggest that PTH may a have a favorable outcome on OTM, most studies were found to have several sources of bias. Conclusion: Animal studies with minimal bias and long-term clinical studies are needed to ascertain the efficacy of intermittent PTH administration in improving the rate and retention of OTM.
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- 2021
348. Application of biomaterials in periodontal tissue repair and reconstruction in the presence of inflammation under periodontitis through the foreign body response: Recent progress and perspectives
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Li Liu, Shengan Rung, Chenyu Chu, Wenlan Xiao, Yili Qu, Yi Man, and Xiwen Zhao
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0301 basic medicine ,Periodontal tissue ,Materials science ,Periodontal Ligament ,Biomedical Engineering ,Inflammation ,Biocompatible Materials ,Bioinformatics ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Tissue damage ,medicine ,Humans ,Periodontitis ,Regeneration (biology) ,Immune regulation ,030206 dentistry ,medicine.disease ,Foreign Bodies ,030104 developmental biology ,medicine.symptom ,Foreign body ,Wound healing - Abstract
Periodontitis would cause dental tissue damage locally. Biomaterials substantially affect the surrounding immune microenvironment through treatment-oriented local inflammatory remodeling in dental periodontitis. This remodeling process is conducive to wound healing and periodontal tissue regeneration. Recent progress in understanding the foreign body response (FBR) and immune regulation, including cell heterogeneity, and cell-cell and cell-material interactions, has provided new insights into the design criteria for biomaterials applied in treatment of periodontitis. This review discusses recent progress and perspectives in the immune regulation effects of biomaterials to augment or reconstruct soft and hard tissue in an inflammatory microenvironment of periodontitis.
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- 2021
349. Development of the System for Assessment of Periodontal Tissue State
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Andrey V. Demidov, Sergey M. Gerashchenko, and Ekaterina V. Udaltsova
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Periodontitis ,Clinical Practice ,Periodontal tissue ,business.industry ,Medicine ,Dentistry ,In patient ,Medical diagnosis ,business ,medicine.disease - Abstract
The article shows the priority of the development of new methods and systems for instant assessment of periodontal tissues state. The electrochemical parameters of periodontal tissues and their relationship with various physiological processes are considered. The existing methods and equipment for periodontal diseases diagnosis and their main disadvantages are considered and described in the article. A new system for assessment of electrochemical parameters of periodontal tissues for instant diagnosis of inflammatory diseases is offered. The requirements for this system and principles of its construction are described in the text of the article. The components of the developed system and its features are described in detail. The structural scheme and algorithm of system operation was developed and described in the article. The article presents the results of a study showing the possibility of using electrochemical information-measuring systems in clinical practice for noninvasive instant diagnosis of periodontal diseases. The study involved 60 patients divided into three groups: with intact periodontal tissues, with moderate periodontitis, and patients after directed tissue regeneration. An increase of the operating current value in patients with an active inflammatory process and a decrease of this parameter in people with intact periodontal tissues and in patients after directed tissue regeneration have been shown.
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- 2021
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350. Extracellular Vesicles: An Emerging Regenerative Treatment for Oral Disease
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Fanzhen He, Lu Li, Ruyi Fan, Xiaoqian Wang, Xu Chen, and Yan Xu
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Periodontal tissue ,QH301-705.5 ,Angiogenesis ,Review ,Extracellular vesicles ,bone ,Cell and Developmental Biology ,oral tissue regeneration ,medicine ,Biology (General) ,cartilage ,business.industry ,Cartilage ,Regeneration (biology) ,Cell Biology ,Oral tissue ,Cell biology ,stomatognathic diseases ,medicine.anatomical_structure ,Oral disease ,periodontal tissue ,dental pulp ,business ,extracellular vesicles ,Homeostasis ,Developmental Biology - Abstract
Extracellular Vesicles (EVs) are small lipid-enclosed particles containing biological molecules such as RNA and proteins that have emerged as vital modulators of intercellular communication. Increasingly, studies have shown that EVs play an essential role in the occurrence and prognosis of oral diseases. EVs are increasingly considered a research hotspot of oral diseases. In addition, the characteristics of carrying active molecules have also been studied in oral tissue regeneration. Evidence has shown that EVs regulate the homeostasis of the inflammatory microenvironment, promote angiogenesis, and repair damaged tissues. In this review, we summarized the characteristics of EVs and highlighted the role of EVs in oral tissue regeneration, including dental pulp, periodontal tissue, cartilage, and bone. We also discussed their deficiencies and prospects as a potential therapeutic role in the regeneration treatment of oral disease.
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- 2021
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