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Edible film merupakan bahan pengemas yang dapat digunakan sebagai pengganti plastik, terutama sebagai bahan pengemas makanan. Edible film memiliki sifat yang mudah terurai dan hidrofilik. Edible film yang marak digunakan di pasaran biasanya dapat dikonsumsi secara langsung seperti pada pembungkus sosis, pembungkus permen, dan masih banyak lagi. Edible film biasanya dibuat dengan bahan baku pati seperti pati gandum, jagung, kentang, tapioka, dan labu kuning. Labu kuning mempunyai potensi yang besar untuk dikembangkan sebagai bahan baku pembuatan edible film, hal ini dikarenakan labu kuning sangatlah banyak dijumpai di negara Indonesia dan ketersediaan sumber dayanya sangat melimpah. Tujuan penelitian ini adalah untuk mengetahui kadar air yang terkandung di dalam edible film, kelarutan edible film terhadap air, dan mengetahui apakah edible film dari pati labu kuning memiliki sifat biodegradable, dengan variabel bebas suhu dan waktu pada saat pencampuran dengan gliserol. Kadar air yang dihasilkan yakni 40%, persentase kelarutan edible film terhadap air yang dihasilkan yakni 57,680% dan sifat biodegradasi pada edible filmyang dihasilkan yakni dapat terdekomposisi dengan baik.Kata Kunci: Biodegradable, Edible Film, Labu Kuning, Pati, Pati Labu Kuning

Intussusception is characterized by abdominal pain, vomiting and blood in stools. However, in younger infants it may present with non-classical symptoms such as listlessness, decreased feeding, and being non-specifically unwell. A Case of intussusception confirmed with the help of an abdominal ultrasound in 5 month old male infant who presented with irritable cry, spasmodic pain, and not taking feeds properly. The purpose of presenting this paper is to suggest a clinical diagnosis of intussusception, and to bring about the awareness of intussusception common in weaning period of very young infants and the latest treatment available which was so simple procedure without any complication and surgery. Keywords: Intussusception, Weaning, Spasmodic.

Introduction Cystic neoplasm of the pancreas is a diverse group of lesions varying from benign to invasive malignant tumours. Though uncommon, they are diagnosed with increased frequency due to the widespread use of cross-sectional imaging for abdominal complaints. Methods We analysed this data from a prospectively maintained database from 1990 to 2020 at a tertiary care hospital in Southern India. Patients' demographic profile, tumour distribution, surgical procedures, and perioperative outcomes including complications were studied. Results A total of 146 cases underwent surgery for cystic neoplasm of the pancreas from 1990 to 2020. The median age at presentation was 37 years (11 to 85 years). The female:male ratio was 3:1. In our study 93.8% of the patients were symptomatic at presentation. The most common location was in the body and tail which was 73.9%. Among the different surgeries performed, 72 (49.3%) underwent distal pancreatico splenectomy, 39 (26.7%) underwent pancreaticoduodenectomy and 33 (22.6%) underwent central pancreatectomy. Laparoscopic/laparoscopic assisted procedures were performed in 17 (11.7%) patients. On histopathology examination most common lesion was SPEN 83(56.8%), 29 (19.9%) were serous cystic neoplasm and 11 (7.5%) had mucinous cystic neoplasm. Mean hospital stay was 9.2 ± 4.2 days. The most common postoperative complication was POPF which was present in 39 (26.7%) and out of them, 6 were grade B/C (4.1%). 8 (5.5%) had postoperative morbidity of Clavien-Dindo grade 3a or more and out of them, 2 (1.4%) had postoperative mortality. Conclusions Cystic neoplasm of the pancreas is most common in the female population. In expert centres, these can be managed with acceptable postoperative morbidity and mortality.

In the present study, we ask whether and how online assessment can inform teaching about students’ understanding of advanced concepts. Our main goal is to illustrate how we study design of tasks that support reliable online formative assessment by automatically analyzing the objects and relations that characterize the students’ submissions. We aim to develop design principles for e-tasks that have the potential to support the creation of rich and varied response spaces that reflect convincingly the students’ perceptions. We focus on studying the design principles of such an interactive rich task, and the representations and tools that support automatic real-time analysis of submitted answers, primarily in the form of free-hand sketches. Using a design research methodology, we describe a two-cycle study focusing on one e-task concerning tangency to the graph of a function. We characterize the mathematical attributes of examples constructed by students in an interactive environment. Checking the correctness of answers is only one of the functions of the STEP platform that we use. That platform can identify submissions that contain partial information (e.g., missing or misplaced tangency points), can categorize these answers, and allow the teacher to analyze them further. The reported analysis demonstrates how the design of the tasks and the characterization of mathematical attributes can help to expand our understanding of different ways of conceptualizing.

Pentingnya sebuah informasi, membutuhkan sebuah alat komunikasi yang pas untuk mengkomunikasikan informasi tersebut kepada para pihak yang memang membutuhkan. Dalam penelitian ini, informasi mengenai pelaporan keuangan diperlukan bagi para istakeholderi. Dalam proses transfer informasi, dibutuhkan alat yang tepat untuk mengolah data yang nantinya akan menghasilkan sebuah informasi. Mengkomunikasikan informasi menggunakan alat Sistem Informasi Akuntansi sangat diperlukan dewasa ini. Untuk itu, tujuan penulis adalah ingin meneliti suatu alat komunikasi yang pas dalam pelaporan laporan keuangan. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan melakukan observasi terhadap perusahaan yang menggunakan sistem informasi dalam melakukan proses pengolahan data. Hasil dari penelitian ini adalah Sistem Informasi Akuntansi merupakan hal yang penting untuk mengkomunikasikan sebuah informasi terutama yang dibutuhkan oleh para manajer di suatu perusahaan disesuaikan dengan departmentnya masing-masing.

Anti-cancer uses of non-oncology drugs have been found on occasion, but such discoveries have been serendipitous and rare. We sought to create a public resource containing the growth inhibitory activity of 4,518 drugs tested across 578 human cancer cell lines. To accomplish this, we used PRISM, which involves drug treatment of molecularly barcoded cell lines in pools. Relative barcode abundance following treatment thus reflects cell line viability. We found that an unexpectedly large number of non-oncology drugs selectively inhibited subsets of cancer cell lines. Moreover, the killing activity of the majority of these drugs was predictable based on the molecular features of the cell lines. Follow-up of several of these compounds revealed novel mechanisms. For example, compounds that kill by inducing PDE3A-SLFN12 complex formation; vanadium-containing compounds whose killing is dependent on the sulfate transporter SLC26A2; the alcohol dependence drug disulfiram, which kills cells with low expression of metallothioneins; and the anti-inflammatory drug tepoxalin, whose killing is dependent on high expression of the multi-drug resistance gene ABCB1. These results illustrate the potential of the PRISM drug repurposing resource as a starting point for new oncology therapeutic development. The resource is available at https://depmap.org.

This article is based on research to analyze the spatial land use development in two lakesides of peri-urban Bandung, Cileunca and Ciburuy lakes. In developing countries, fast-growing populations, urbanization, and rising economic sectors cause a vast demand for residential areas and supporting facilities for the residents, work labors, and office workers. Consequently, in able to deliver those demands, development in the peri-urban area is inevitable. In peri-urban Bandung, some developments tend to happen nearby the lakes; it provides the source for water, basic sanitation, and recreational space for surrounding residents and visitors. Later, the dynamic change of land use also occurs, following the rapid expansion of industrial area and tourism business. Sustainable housing development in urban Bandung is arguably integrated into those dynamic activities of the peri-urban. The method of this research is comparing spatial transformation and empirical investigation to evaluate the driving forces behind the land use conversion in Lakeside area of peri-urban Bandung. The results show that the development and land use alteration in Situ Cileunca’s lakeside settlement area is intensifying after the tourism activities take place. Conversely, industrial expansion and proximity to Bandung city more likely influence the development of physical infrastructure in Situ Ciburuy’s lakeside.

Educators are continually faced with new challenges to keep up with rapid technological changes in order to help students prepare for their futures. The 21st-century learning involves students in the learning process that could develop their knowledge and skills in terms of Information, Communications and Technology (ICT) literacy. This study aimed to measure students’ ICT literacy of using Augmented Reality (AR) in the accounting learning process. The result of this study found that students could develop their ICT literacy through the application of Android-based AR technology. This study showed that the use of AR holds the potential to be innovative multimedia in 21st-century learning.

This study aims to describe the learning style of accounting students in the 4.0 industrial revolution era which is seen from the meaning of 4.0 Industrial Revolution Era and revealing that meaning to the learning style of accounting students. This study uses a qualitative descriptive method with a phenomenology approach to reveal the meaning of the 4.0 Industrial Revolution Era so as not to interfere with other perceptions outside the subject's self. The subjects in this study were four accounting students. The research data was collected using interview methods, documentation, and observation. The results of this study conclude that the meaning of the industrial revolution 4.0 era for accounting students is a time when all information can be easily obtained without any space and time limits. According to accounting students, this era greatly influenced their learning styles, because with this era the way to get the latest material and information about the subjects can be done very easily anywhere and anytime.

Approximately 70% of breast cancers express estrogen receptor alpha (ERα), a hormone-regulated transcription factor, making it an excellent target for endocrine therapy. When endogenous and exogenous ligands engage ERα, the receptor binds to regulatory regions in the genome known as enhancers, where it associates with coregulatory proteins, increases histone modifications associated with active enhancers, promotes chromatin looping, stimulates enhancer transcription and the production of enhancer RNAs (eRNAs), and ultimately regulates target gene transcription. We have previously used global run-on sequencing (GRO-seq), a high-throughput method that identifies the location and orientation of all transcriptionally active RNA polymerases across the genome, to identify active enhancers based on enhancer transcription and enrichment of the aforementioned genomic features. Current studies on the roles of eRNAs have suggested that eRNAs may 1) recruit regulatory proteins to enhancers; 2) promote RNA polymerase II transition; 3) regulate histone modification; and 4) increase chromosome looping. One challenge facing the field is the lack of accurate eRNA annotations and cloned full-length eRNAs; eRNAs have typically been studied as signals from genomic assays on ‘browser tracks,’ not as physical entities (e.g., cDNAs). We have employed precision nuclear run-on of capped RNA (PRO-cap) to determine the transcription start sites of all expressed eRNAs. In addition, we have also used ultra-deep RNA-sequencing of polyA-depleted and polyA-enriched RNA fractions to detect eRNAs and examine for the potential splicing of eRNAs. Combining these genomic data, our annotations provide critical information for the large-scale cloning of eRNAs. We are now testing whether eRNAs originating from ERα enhancers may regulate target gene expression, either in cis or in trans. We cloning specific eRNAs based on our genomic annotations and testing them either by (1) tethering them to their cognate ERα enhancers by using CRISPR/dCas9 technology (i.e., cis) or (2) ectopically expressing them (i.e., trans) in MCF-7 breast cancer cells. Ultimately, our genomic annotation and biochemical tools will allow us to determine the mechanisms by which eRNA contribute to ERα enhancer assembly and function. This work is supported by grants from the NIH/NIDDK (DK058110) and CPRIT (RP160319) to W.L.K.

Sleep is ubiquitous in vertebrates and invertebrates, and its chronic lost is typically associated with reduced performance, health, or survival. Nevertheless, some animals can give up sleep in order to increase survival or mating opportunities. We studied the interplay between sleep and brood care in the social bumblebeeBombus terrestris. We first used video recording and detailed behavioral analyses to confirm that the bumblebee shows the essential behavioral characteristics of sleep. Based on these analyses we next used immobility bouts of >5′ as proxy for sleep in automatic activity monitoring records, and found that sleep is severely reduced in the presence of larvae that require feeding or pupae that are not fed. Reduced sleep was correlated with wax pot building, which is a behavior typical to nest founding mother queens. Sleep was also reduced in the presence of empty cocoons, but this effect was transient and reduced with time. This observation that is consistent with the presence of a sleep modulating pheromonal signal. These results provide the first evidence for brood modulation of sleep in an insect, and are consistent with the hypothesis that plasticity in sleep can evolve as a mechanism to improve care for dependent juveniles.

International audience; This paper presents a discrete conducted electromagnetic interference filter optimization procedure, based on a Genetic Algorithms. A macro-modeling technique taking into account the load impedance, the source emissions and the filter parasitic components, including the filter layout, is used to obtain an accurate solution for the optimization process. The latter searches among supplier passive component databases and provides, for a given filter topology, an optimal set of components available on the market. This approach has been applied to a differential Class-D audio amplifier for validation. By considering the EMI, the additional power losses introduced by the filter and the audio gain, two different optimization formulations have been tested. The first corresponds to maximizing the power efficiency of the system while respecting a determined level of electromagnetic emissions. The second corresponds to minimizing the EMI without exceeding a determined level of power loss. The optimized filters are built and measurements are carried out. The results show a remarkable power efficiency improvement and a significant EM emission reduction when compared to a reference filter.

Penelitian ini tentang hak akses terhadap pelayanan kesehatan untuk masyarakat miskin peserta KIS di kabupaten Boyolali. Permasalahan muncul pada saat kebijakan publik dari pemerintah pusat tidak sejalan dengan kebijakan organisasi dari institusi setempat.Berbagai persoalan muncul terkait dengan implementasi kebijakan tersebut yang semuanya akan bermuara pada kualitas pelayanan publik di bidang kesehatan. Tujuan penelitian adalah peningkatan kualitas pelayanan kesehatan bagi masyarakat miskin Boyolali Metode penelitian perspektif deskriptif kualitatifd dengan teknik pengumpulan data observasi , wawancara mendalam dan arsip dokumrn tertulis pengolahan data di analisis data terdiri dari reduksi data, penyajian data penarikan kesimpulan sementara serta verifikasi Pelayanan kesehatan di Puskesmas Mojosanga sudah melampaui Standart pelayanan minimum bidang kesehatan Permenkes Nomor 43 Tahun 2016 namun demikian ada satu item yaitu perawatan ibu melahirkan karena tidak adanya ruang rawat inap sehingga puskesmas akan merujuk ke RS yang mempunyai sarana tersebut.Dalam perpestif masyarakat miskin penerima kesehatan dari puskesmas Mojosanga, pelayanan yang diberikan dari puskesmas dirasakan lebih dari cukup baik menyakut pelayanan administrasi maupun medis Kata Kunci: Kualitas Pelayanan, Keluarga Miskin, dan Kesehatan