301. Therapeutic perspectives of epigenetically active nutrients.
- Author
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Remely M, Lovrecic L, de la Garza AL, Migliore L, Peterlin B, Milagro FI, Martinez AJ, and Haslberger AG
- Subjects
- Antineoplastic Agents pharmacology, Coffee, Curcumin pharmacology, Folic Acid pharmacology, Food, Gene Expression Regulation drug effects, Humans, Polyphenols pharmacology, S-Adenosylmethionine pharmacology, Selenium pharmacology, Vitamin B 12 pharmacology, Vitamin B Complex pharmacology, Diet, Epigenesis, Genetic drug effects, Gene Expression Regulation, Neoplastic drug effects, Metabolic Syndrome genetics, Neoplasms genetics, Neurodegenerative Diseases genetics, Phytoestrogens pharmacology, Trace Elements pharmacology, Vitamins pharmacology
- Abstract
Many nutrients are known for a wide range of activities in prevention and alleviation of various diseases. Recently, their potential role in regulating human health through effects on epigenetics has become evident, although specific mechanisms are still unclear. Thus, nutriepigenetics/nutriepigenomics has emerged as a new and promising field in current epigenetics research in the past few years. In particular, polyphenols, as part of the central dynamic interaction between the genome and the environment with specificity at physiological concentrations, are well known to affect mechanisms underlying human health. This review summarizes the effects of dietary compounds on epigenetic mechanisms in the regulation of gene expression including expression of enzymes and other molecules responsible for drug absorption, distribution, metabolism and excretion in cancer, metabolic syndrome, neurodegenerative disorders and hormonal dysfunction., (© 2014 The British Pharmacological Society.)
- Published
- 2015
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